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Dissertations / Theses on the topic 'Randomised clinical trial (RCT)'

Author: Grafiati

Published: 20 July 2024

Last updated: 31 July 2025

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1

Anjara, Sabrina Gabrielle. "A study of two models of primary mental health care provisions in Yogyakarta, Indonesia." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289729.

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Background The World Health Organization (WHO) defines health as a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity. Despite its importance, mental health provisions are often limited. In 2015, Indonesia had only 773 psychiatrists for 250 million residents. This shortage of specialist mental health professionals is shared by most Low- and Middle-Income Countries (LMICs) and is reflected in the Treatment Gaps in this region indicating the very small proportion of people who receive adequate mental health care for their needs. While the

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2

Daures, Maguy. "Évaluation d'une stratégie de prise en charge simplifiée de la malnutrition aiguë chez des enfants de 6 à 59 mois en Afrique Sub-saharienne dans le cadre d’un programme de recherche co-construit entre humanitaires et chercheurs." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0067.

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La malnutrition aiguë (MA) est un défi mondial, touchant 45 millions d'enfants de moins de 5 ans et est une cause sous-jacente de 800 000 décès annuels. Les protocoles de prise en charge, bien que efficaces, souffrent d'un financement insuffisant et d'une couverture limitée. Ces protocoles divisés en deux programmes pour les enfants malnutris aigus sévères et modérés sont complexes et utilisent des traitements différents avec des dosages non optimaux. Pour répondre à ces défis, l’organisation non gouvernementale (ONG) « The Alliance for International medical action » (ALIMA) a développé le pro

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3

Deak, Stefan, and Glenn Kristoffersson. "Rädslan för det som finns och inte finns : En randomiserad kontrollerad jämförelse av utfall mellan sedvanlig ensessionsbehandling och behandling med virtuella stimuli mot spindelfobi." Thesis, Stockholms universitet, Psykologiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-130712.

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Specifik fobi är en vanlig psykiatrisk åkomma som kan leda till stora individuella begränsningar. Symtomen kan framgångsrikt behandlas med kognitiv beteendeterapi där 85–90 % blir kliniskt signifikant förbättrade. Forskning påvisar lovande behandlingsutfall för virtuell exponeringsbehandling (VRET) mot spindelfobi. Tekniken är intressant då den kringgår de problem med anskaffning och förvaring av fobiska stimuli som sedvanlig behandling medför och dessutom kan innebära ökad tillgänglighet och flexibilitet vid behandling. Syftet med föreliggande studie är att jämföra behandlingseffekten av ense

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4

Nohlert, Eva. "Smoking Cessation : Treatment Intensity and Outcome in Randomized Clinical Trials." Doctoral thesis, Uppsala universitet, Centrum för klinisk forskning, Västerås, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-208972.

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The primary aim was to compare the effectiveness of smoking cessation interventions of different intensities in a clinical dental and a telephone setting in Sweden. Methods: A total of 300 smokers were randomized to High or Low Intensity Treatment (HIT or LIT) at the Public Dental Service, County Council of Västmanland. Effectiveness (abstinence rate) was measured after 1yr (paper I) and 5-8yrs (paper III). A cost-effectiveness analysis was conducted, based on intervention costs, number of abstinent participants after 1yr, and a Markov modelling of future costs and health (in QALYs) consequenc

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5

Walid, Rania. "Impact Evaluation in Post-conflict Environments : A Critical Appraisal of Randomised Controlled Trial (RCT)." Thesis, Linnéuniversitetet, Institutionen för samhällsstudier (SS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-104816.

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Impact evaluations in development interventions has been growing in recent years. The increasing demand for evidence-based outcomes has led to a debate of what methodology is best to evaluate the impact of development interventions. Accordingly, Randomised Controlled Trial (RCT) has been labeled as a gold standard for impact evaluations. The RCT method functions in a unique way, as it removes the selection bias and ensure high validity of a study. The aim of this research study is to critically assess the RCT as an alternative approach for impact assessment in relation to post-conflict countri

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6

Spieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-215848.

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Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle of equipoise and its practical applicability to clinical science with an emphasis on critical care and neurological research. We performed a review of educational material, review articles, methodological studies, and published clinical trials u

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7

Spieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Dove Medical Press, 2016. https://tud.qucosa.de/id/qucosa%3A29007.

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Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle of equipoise and its practical applicability to clinical science with an emphasis on critical care and neurological research. We performed a review of educational material, review articles, methodological studies, and published clinical trials u

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8

Featherstone, Katie. "Patient perspectives of participation in a randomised controlled trial." Thesis, University of Bristol, 2000. http://hdl.handle.net/1983/06229618-6e8d-4764-8c7a-1f0c0d0af307.

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9

Schuh, Sr Matthew Anderson. "The Epistemic Necessity and Ethical Permissibility of Randomized Clinical Trials: A Minimalist Defense." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/167.

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I argue for two main theses that are at odds with the positions of many clinical researchers and philosophers who write on the ethics of clinical research. The first is that certain types of clinical trials, namely, randomized clinical trials with double or triple blinding and a placebo group are generally necessary to establish that a medical intervention is effective in treating a certain type of disease or disorder. The second main thesis is that such trials are generally not ethically impermissible. My minimalist defense of clinical trials differs from most defenses of clinical trials fou

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10

Slater, Karen. "Improving Care of Peripheral Intravenous Needleless Connectors." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/412414.

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Background: Most hospitalised patients have a peripheral intravenous catheter (PIVC) at some point during hospitalisation. Although the rate of bloodstream infection (BSI) for PIVCs is low, the sheer number of devices inserted makes them a device of interest, since cumulatively many infections occur worldwide each year. Access to intravenous (IV) lines for the administration of medication and fluids in most of the developed world is through the needleless connector (NC) component of a PIVC. NCs were introduced several decades ago to reduce the risk of needlestick injuries amongst healthcare wo

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11

Rickard, Claire. "Prolonged use of intravenous administration sets: a randomised controlled trial." Thesis, Queensland University of Technology, 2004. https://eprints.qut.edu.au/15974/1/Claire_Rickard_Thesis.pdf.

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The purpose of this research study was to improve the nursing care of intravenous catheters by providing evidence on the effects of prolonged duration of intravenous administration set use. Intravenous therapy is a vital part of modern health care. However, its invasive nature can result in infection, with high associated morbidity and mortality. The highest infection rates are displayed in intensive care patients with central venous catheters. The duration of intravenous administration set use may have an impact on infection rates,however the current practice usage and the optimum durat

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Rickard, Claire. "Prolonged use of intravenous administration sets: a randomised controlled trial." Queensland University of Technology, 2004. http://eprints.qut.edu.au/15974/.

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The purpose of this research study was to improve the nursing care of intravenous catheters by providing evidence on the effects of prolonged duration of intravenous administration set use. Intravenous therapy is a vital part of modern health care. However, its invasive nature can result in infection, with high associated morbidity and mortality. The highest infection rates are displayed in intensive care patients with central venous catheters. The duration of intravenous administration set use may have an impact on infection rates,however the current practice usage and the optimum durat

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Henderson, Neil James Kerr. "Extending the clinical and economic evaluations of a randomised controlled trial the IONA study /." Connect to e-thesis, 2008. http://theses.gla.ac.uk/418/.

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Thesis (Ph.D.) - University of Glasgow, 2008.<br>Ph.D. thesis submitted to the Department of Statistics, Faculty of Information and Mathematical Sciences, University of Glasgow, 2008. Includes bibliographical references. Print version also available.

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14

Parkin, Nicola Ann. "Open versus closed exposure of palatally displaced canines : a randomised clinical trial." Thesis, University of Sheffield, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.575857.

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Purpose: To investigate the differences in outcomes between Open and Closed exposures of PDC. The primary outcome assessed is periodontal health; secondary outcome measures include economics and patient response. Methods: A multicentre randomised controlled trial involving two parallel groups. The settings were one dental teaching hospital (Charles Clifford Dental Hospital, Sheffield) and two regional peripheral hospital units. Individuals aged under 20 years with unilateral PDC were identified as potential participants using specific inclusion and exclusion criteria. Those patients or their p

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15

Handley, Alicia Katherine. "A randomised controlled trial of group cognitive behavioural therapy for clinical perfectionism." Thesis, Curtin University, 2014. http://hdl.handle.net/20.500.11937/802.

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This thesis consisted of two linked studies. The first study examined the relationship between perfectionism and generalised anxiety disorder symptoms in a clinical sample. Perfectionism demonstrated significant associations with pathological worry and a principal diagnosis of generalised anxiety disorder. The second study examined the efficacy of group cognitive behavioural therapy for clinical perfectionism in a clinical sample. This treatment produced significant reductions in perfectionism and psychopathology and significant increases in self-esteem and quality of life.

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16

Acharya, Dev Raj. "Measuring the effectiveness of teaching sex education in Nepalese secondary schools : an outcome from a Randomised Controlled Trial (RCT)." Thesis, Aberystwyth University, 2014. http://hdl.handle.net/2160/7aed061b-668e-4789-879e-b30ba401b6c6.

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This study aimed to identify the effectiveness of delivering sex education in secondary schools in Hetauda (Nepal) by exploring the sexual health knowledge and understanding of young people, and parents' and teachers' views on sex education, in order to place the findings in the wider social, cultural and educational context of modern Nepal. The research selected four secondary schools pupils of diverse sociobackground characteristics in Hetauda municipality, central Nepal. This study was conducted by undertaking an intervention in control (2 schools) and experiment (2 schools) groups, and as

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17

Woodford, Joanne. "Development and feasibility randomised controlled trial of guided Cognitive Behavioural Therapy (CBT) self-help for informal carers of stroke survivors." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/17401.

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Background: One-in-three carers of stroke survivors experience depression with no psychological treatments tailored to meet their needs, such as barriers to attending traditional face-to-face psychological services. A cognitive behavioural therapy (CBT) self-help approach may represent an effective, acceptable solution. Methods: Informed by the MRC framework (2008) for complex interventions, six studies informed development, feasibility and piloting of a CBT self-help intervention for depressed carers of stroke survivors: Study One: Systematic review and meta-analysis of psychological interven

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18

Tohotoa, Jennifer Lynn. "The development, implementation and evaluation of a father inclusive perinatal support intervention to increase breastfeeding duration : a randomised controlled trial." Thesis, Curtin University, 2012. http://hdl.handle.net/20.500.11937/1542.

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Breastfeeding is the biological norm for infant feeding and the most efficient and cost-effective method of giving the required nutrition to infants. The World Health Organization, the American Academy of Paediatrics and the National Health and Medical Research Council recommend exclusive breastfeeding for six months and the continuation of complementary foods for up to two years. Although most developed countries maintain high initiation rates, the duration rates fail to meet these recommendations. The promotion of breast milk substitutes, changing societal values, urbanization, and the erosi

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19

McArdle, Gerarde T. "A prospective randomised clinical trial comparing undergoing electric infrarenal abdominal aortic aneurysm repair." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534687.

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20

Guarino, Peter David. "Consumer participation in the design of informed consent documentation for entry into randomised clinical trials : a cluster randomised trial." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422313.

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21

Watson, Hunna J. "Clinical and research developments in the treatment of paediatric obsessive-compulsive disorder." Thesis, Curtin University, 2007. http://hdl.handle.net/20.500.11937/2374.

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It is of crucial importance to identify and disseminate effective treatments for paediatric obsessive-compulsive disorder (OCD). OCD is time-consuming and distressing, and can substantially disable functioning at school, at home, and with peers (Piacentini, 2003). Children who do not receive treatment are at risk of psychological difficulties in adulthood, including continued OCD, clinical anxiety and depression, personality disorders, and social maladjustment (Wewetzer et al., 2001). Two-thirds of adult cases of OCD develop in childhood, and adults with OCD have lower employment, poorer acade

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22

Hutchison, Catherine B. "A randomised controlled trial of an audiovisual patient information intervention in cancer clinical trials." Thesis, University of Stirling, 2008. http://hdl.handle.net/1893/442.

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Introduction and background Recruitment to cancer clinical trials needs to be improved, as does patient understanding about clinical trials, to enable patients to make an informed choice about whether or not to take part. The main reason that clinically eligible patients do not take part in clinical trials is because they refuse; poor understanding of the research has been associated with patient refusal. Audiovisual patient information (AVPI) has been shown to improve knowledge/understanding in various areas of practice but there is limited information about its effect in the cancer clinical

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23

Henderson, Neil J. K. "Extending the clinical and economic evaluations of a randomised controlled trial : the IONA Study." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/418/.

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In modern society people are concerned about their state of health and if they do unfortunately become ill they want the best possible treatment to be made available to them. In order to satisfy these demands new treatments have to be developed. This can be a long and expensive process. Before any new treatment can come to market it has to be proved to be both clinically effective and economically cost-effective. With limited health care resources the cost-effectiveness of treatments is becoming ever more relevant. In order to show whether a treatment is clinically effective a clinical trial i

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24

Hoiles, Kimberley Jo. "A Randomised Controlled Trial of Guided Self-Help Cognitive Behaviour Therapy for Clinical Perfectionism." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/51902.

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Perfectionism has been found to be elevated across disorders, with evidence that it can interfere with treatment outcome. Study 1, provides evidence of convergent validity of the CPQ in a mixed clinical sample (N = 32). In Study 2, guided self-help CBT for clinical perfectionism decreased perfectionism and psychopathology in an elevated perfectionism sample (N = 40) with self-criticism mediating treatment outcome. The intervention also reduced primary DSM-IV diagnosis and comorbid presentations.

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25

Coskinas, Xanthi. "Changes to design aspects of ongoing randomised controlled trials." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29452.

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Unplanned changes to the research plan of a randomised controlled trial (RCT) may be a necessary response to unforeseen circumstances. Such changes can help ensure the value and relevance of a trial, but also have the potential to introduce a bias if performed inappropriately. This thesis addresses three broad aims. The first was to highlight the methodological implications of approaches to making various unplanned changes through a series of simulation studies. The second was to estimate the prevalence of such changes to a contemporary sample of published RCTs registered with the Australi

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26

Ferrante, di Ruffano Lavinia. "Using randomised controlled trials to evaluate the clinical effectiveness of diagnostic tests : how useful are test-treatment RCTs?" Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4269/.

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Background: Decisions on which tests to use should be informed by evidence that they do more good than harm. Test-treatment RCTs are recommended as the ‘gold–standard’ approach, but have attracted criticism that question whether they are fit for purpose. Confronting this question, the thesis investigates four key challenges by finding and analysing all identifiable test-treatment RCTs (2004–2007). Methods: Capture–recapture analysis estimated the total population of trials; descriptive analysis characterised the diagnostic questions evaluated by RCT; reviews of reporting and methodological qua

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Ford, Shane Alwyn. "Delivering Acceptance and Commitment Therapy (ACT) for mental health disorders across group and guided self-help formats : a meta-analysis and randomised controlled trial." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25924.

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Background: Acceptance and Commitment Therapy (ACT) has shown promise as an effective intervention in the treatment of mental health disorders. In the last decade, the delivery of ACT has expanded to include various formats (e.g. groups, self-help, online and phone apps). Further research is needed to evaluate whether such delivery formats are a viable extension of ACT. Furthermore, the existing evidence base of certain alternative delivery formats have yet to be reviewed. This thesis portfolio sought to contribute to this area of research. Methods: A systematic review of the literature was co

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28

Chuayna, Nonglak. "Implementing clinical guidelines in nurse-led primary health care in Thailand : a randomised controlled trial." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274428.

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29

Watson, Hunna J. "Clinical and research developments in the treatment of paediatric obsessive-compulsive disorder." Curtin University of Technology, School of Psychology, Division of Health Sciences, 2007. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=115091.

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It is of crucial importance to identify and disseminate effective treatments for paediatric obsessive-compulsive disorder (OCD). OCD is time-consuming and distressing, and can substantially disable functioning at school, at home, and with peers (Piacentini, 2003). Children who do not receive treatment are at risk of psychological difficulties in adulthood, including continued OCD, clinical anxiety and depression, personality disorders, and social maladjustment (Wewetzer et al., 2001). Two-thirds of adult cases of OCD develop in childhood, and adults with OCD have lower employment, poorer acade

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30

Dakin, Helen A. "Economic evaluation of factorial randomised controlled trials." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:77eda1f6-dd8c-439a-8871-75fd57a4c7f5.

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Factorial randomised controlled trials (RCTs) evaluate two or more interventions simultaneously, enabling assessment of interactions between treatments. This thesis presents literature reviews, methodological reviews, simulation studies and applied case studies that explore methods for assessing cost-effectiveness based on factorial RCTs. My systematic review suggests that factorial RCTs account for around 3% of trial-based economic evaluations, although there is currently no guidance or methodological work indicating the most appropriate methods. Around 40% of published studies assumed no int

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WANZIRA, HUMPHREY. "Supportive Supervision as an approach to improve the quality of care for children with acute malnutrition in Arua district, Uganda: Baseline systematic assessment, Cluster Randomised Controlled Trial and Cost-Effectiveness Analysis." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2962380.

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INTRODUCTION Moderate and severe acute malnutrition estimates among children in the West Nile region, in Uganda, are higher than the national level (10.4% and 5.6%, respectively versus 3.6 % and 1.3 %). Additionally, the WHO estimates that in 2016, 6.6 million children and young adolescents died from causes attributed to the poor quality of care in such similar settings. Supportive supervision (SS) has been proposed as one of the approaches to improve quality of care. The main objectives of this project were; to determine the baseline status of the quality of care of nutrition services and he

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32

Littleton, Heather, Amie E. Grills, Katherine D. Kline, Alexander M. Schoemann, and Julia Dodd. "The From Survivor to Thriver Program: RCT of an Online Therapist-Facilitated Program for Rape-Related PTSD." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/7326.

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This study evaluated the efficacy of the From Survivor to Thriver program, an interactive, online therapist-facilitated cognitive-behavioral program for rape-related PTSD. Eighty-seven college women with rape-related PTSD were randomized to complete the interactive program (n = 46) or a psycho-educational self-help website (n = 41). Both programs led to large reductions in interview-assessed PTSD at post-treatment (interactive d = 2.22, psycho-educational d = 1.10), which were maintained at three month follow-up. Both also led to medium- to large-sized reductions in self-reported depressive an

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33

Machai, Maria José Pires. "A school-based intervention for improving malaria-related knowledge and practices in Maputo Province, Mozambique : a randomised controlled trial." Master's thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3288.

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Includes abstract.<br>Includes bibliographical references (leaves 63-66).<br>The aim of the study was to evaluate the impact of a school-based malaria education intervention and its effectiveness in the changing knowledge and practices related to malaria at randomly selected schools in Maputo Province.

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Juriansz, A. "Conservative treatment of hallux valgus : a randomised controlled clinical trial of a hallux valgus night splint." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541455.

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Nienhuis, Saskia Johanna. "Costs and effects of Doppler ultrasound measurements in suspected intrauterine growth retardation a randomised clinical trial /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=6637.

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Wiffen, Benjamin David Richard. "Online CBT for individuals with Christian beliefs : a pilot randomised controlled trial : and Clinical Research Portfolio." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5551/.

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Objectives: To investigate proof of concept, feasibility and efficacy of an online Cognitive Behavioural Therapy (CBT) intervention, modified to appeal to Christians who may be reluctant to access secular mental health services. Methods: 52 volunteers with Christian beliefs experiencing low mood or anxiety were recruited (median age=46.5, 25% male) to a pilot randomised waiting-list controlled trial of an online Spiritually-integrated CBT resource, with assessments at baseline, 8 weeks and 12 weeks. Primary outcome measures addressed mood, anxiety and general functioning. Results: No significa

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GNESINI, Giulia. "REGULAR VERSUS RESCUE BUDESONIDE AND FORMOTEROL COMBINATION FOR MODERATE ASTHMA: A NON INFERIORITY RANDOMISED CLINICAL TRIAL." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2389072.

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Wang, Yanyi, and s3042947@student rmit edu au. "Evaluation of effectiveness and safety of acupuncture in the treatment of migraine: A systematic review and a randomised controlled trial." RMIT University. Health Science, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20091113.102639.

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Migraine affects 8 -16% of population in different countries resulting in significant economic and social impacts. Current pharmacological treatment provides symptomatic relief, but not without side effects. Hence, an increasing proportion of patients prefer complementary therapies including acupuncture for migraine relief. Randomised controlled trials (RCTs) of acupuncture treatment for migraine have produced conflicting evidence due to methodological and reporting deficiencies, including small sample sizes and inappropriate outcome measures. Furthermore, systematic reviews on acupunctu

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曾偉賢 and Wai-yin Tsang. "Analysis of data from a double-blind, placebo-controlled randomised clinical trial for the treatment of stroke." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31977509.

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Tsang, Wai-yin. "Analysis of data from a double-blind, placebo-controlled randomised clinical trial for the treatment of stroke." Hong Kong : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13787007.

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Clough, Bonnie Anne. "Technological Adjuncts to Increase Adherence to Therapy: The Role of Mobile Phones." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366844.

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The aim of this thesis was to investigate the use of mobile phones as an adjunct to face-to-face psychotherapy. This aim was developed from two structured reviews of the literature concerning the types of adjunctive technologies in use, and the ways in which they have been used to increase adherence. Adjunctive use of the mobile phone was investigated in regards to its capacity to achieve greater client adherence and engagement in therapy, in order to facilitate improved treatment outcomes and client satisfaction. This overarching aim and hypothesis was investigated in three empirical studies,

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Bagnall, Kara Marie. "Long-term follow-up of NetmumsHWD : a feasibility randomised controlled trial of telephone supported online behavioural activation for postnatal depression at 16 months post-randomisation." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/15289.

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Purpose: Postnatal depression has significant negative outcomes for both mother and baby. Cognitive-behavioural interventions have proven promising in its treatment, but there are a number of barriers, specific to the postnatal period, which lead to low take-up of treatment. Online interventions may circumvent some of these barriers. However, evidence of long-term follow-up is sparse, in spite of the importance of knowing how such treatments work over the longer-term. Methods: Long-term follow-up of postnatal women participating in a feasibility randomised controlled trial of NetmumsHWD, an on

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Tagney, Jenny. "A randomised, clinical trial of a psycho-educational nursing intervention in patients receiving an Implantable Cardioverter Defibrillator." Thesis, University of the West of England, Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601373.

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Implantable cardioverter defibrillators prevent Sudden Cardiac Death (SCD) in at-risk populations. Coming to terms with having an ICD, risk of SCD and a long-term condition may be impeded by negative psycho-social effects. Nurse-led psychoeducative support interventions have been trialled with mixed outcomes. As neither usual care or skills and knowledge of nurses delivering interventions were detailed, applicability within UK healthcare was unclear. This clinical trial tested a psychoeducational support intervention with usual care using arrhythmia clinical nurse specialists. Method Sixty-thr

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Walker, Becky J. "A comparison of mandibular arch width changes using two different bracket systems : a randomised controlled clinical trial." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.681744.

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AIMS: The primary aim was to assess and compare mandibular arch width changes between self-ligating and non-self-ligating brackets using superelastic nickel titanium archwires. DESIGN: Single-centre prospective randomised controlled clinical trial. SETTING: Orthodontic department, Queen Alexandra Hospital, Portsmouth. PARTICIPANTS: 92 consecutive patients seen in the department who fulfilled the selection criteria. INTERVENTIONS: All patients were treated with upper and lower fixed appliances on a nonextraction basis. Patients were randomly assigned to Damon Q self-ligating or Orthos non-selfl

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Shore, Rob M. "A randomised controlled trial of an online mindfulness-based intervention for paranoia in a non-clinical population." Thesis, University of Surrey, 2015. http://epubs.surrey.ac.uk/808489/.

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Objectives : Paranoia is common in the general population and can impact on health, emotional well-being and social functioning; therefore effective interventions are needed. Brief online mindfulness-based interventions (MBIs) have the potential to be an easily accessible, low cost treatment for non-clinical populations. There is promising evidence for brief online MBIs for anxiety and depression however at present there is no research investigating whether they can benefit people with paranoia in the general population. Therefore the current study explored whether a brief online MBI increased

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Sadler, Paul. "Cognitive behaviour therapy for insomnia and depression among older adults : A mixed methods randomised controlled clinical trial." Thesis, Federation University Australia, 2018. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/168037.

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Background A strong relationship exists between insomnia and depression, particularly among older adults (aged 65 years and older). Recently experts in the field of behavioural sleep medicine established cognitive behaviour therapy (CBT) was an effective treatment for comorbid insomnia, however, it was unknown whether cognitive behaviour therapy for insomnia (CBT-I) benefitted older adults with co-occurring depression (literature review published in Cognitive Behaviour Therapy). A mixed-methods randomised controlled clinical trial (RCT) was warranted within a community mental health setting to

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Williams, Catherine Elizabeth Mary. "A randomised controlled trial comparing two approaches to preschool vision screening in children under the age of 37 months." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285811.

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Russell, Trevor G. "Establishing the efficacy of telemedicine as a clinical tool for physiotherapists : from systems design to randomised controlled trial /." [St. Lucia, Qld.], 2004. http://adt.library.uq.edu.au/public/adt-QU20040608.114117/index.html.

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Toth, Benjamin. "Clinical trials in British medicine 1858-1948, with special reference to the development of the randomised controlled trial." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364843.

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Haynes, Richard. "The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:01ba360a-fe6a-4a1a-ba14-48a2dcc3e0dd.

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Niacin has been in clinical use for over 50 years and was the first drug shown in a randomized trial to improve outcomes after MI, but substantial uncertainty remains about its efficacy and safety in the context of current standard medical therapy. This thesis explores the biochemical efficacy, tolerability and safety of extended release (ER) niacin/laropiprant in the large, randomized HPS2-THRIVE trial. Laropiprant is a prostaglandin D₂ receptor (DP1) antagonist which reduces the main adverse effect of niacin, namely “flushing” (an unpleasant cutaneous vasodilation) that makes a large trial o

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