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1

Brymer, Christopher David. A randomized, double-blind, placebo-controlled crossover trial of nimodipine for geriatric urge incontinence. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1999.

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2

Drury, Valerie Mary. Cognitive therapy and recovery from acute psychosis: A randomised controlled trial. Birmingham: University of Birmingham, 1999.

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3

Sawyer, Lynn. Low vs high glycaemic index bedtime snacks for patients with type 1 diabetes, which should we be encouraging?: A randomised controlled cross-over trial. Roehampton: University of Surrey Roehampton, 2004.

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4

Wilson, Patricia Ann. Can a soother do more than soothe?: A randomised controlled trial to determine the effects of non-nutritive sucking on feeding and growth in preterm infants. [S.l: The Author], 1998.

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5

Roukema, Henry. A randomised controlled trial of infant flow continuous positive airway pressure versus nasopharyngeal continuous positive airway pressure in the extubation of infants [less then a equal]1250 grams. Ottawa: National Library of Canada, 2003.

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6

Hall, M. A prospective randomised controlled trial to compare Duoderm, a thin hydocolloid dressing, with Jelonet, a paraffin gauze product in the management of fingertip amputation wounds that do not require surgical intervention. Oxford: Oxford Brookes University, 2002.

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7

N, Caine, National Co-ordinating Centre for HTA (Great Britain), and Health Technology Assessment Programme, eds. A randomised controlled crossover trial of nurse practitioner versus doctor-led outpatient care in a bronchiectasis clinic. Southampton: NCCHTA, 2002.

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8

Peacock, Janet L., and Sally M. Kerry. Presenting a randomised controlled trial. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780198599661.003.0012.

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9

Harrison, Mark. Types of trials. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0059.

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This chapter describes types of trials as applied to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details and advantages and disadvantages of case reports, case series, cohort studies, case–control studies, randomized controlled trials, crossover trials, systematic reviews, and meta-analysis. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.
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10

Burke, Rebecca, and Akhila Reddy. Duloxetine for Chemotherapy-Induced Peripheral Neuropathy (DRAFT). Edited by Nathan A. Gray and Thomas W. LeBlanc. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190658618.003.0015.

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This chapter discusses the Smith et al. randomized, double-blind, placebo-controlled crossover trial determining the effectiveness of duloxetine compared to placebo in reducing painful chemotherapy-induced peripheral neuropathy. Patients were divided into the duloxetine-first or placebo-first group, then subsequently crossed over to the alternate group. The study particularly examined changes in pain severity, quality of life, interference with daily function, and adverse events. The study demonstrated that patients receiving duloxetine first reported a statistically significant decrease in pain, improvement in quality of life, and decreased pain interference with daily functioning. This chapter describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case.
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11

Jane, Morrell C., and National Co-ordinating Centre for HTA (Great Britain), eds. Costs and benefits of community postnatal support workers: A randomised controlled trial. Alton: Core Research on behalf of the NCCHTA, 2000.

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12

J, Morrell C., and National Co-ordinating Centre for HTA (Great Britain), eds. Costs and benefits of community postnatal support workers: A randomised controlled trial. Alton: NCCHTA, 2000.

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13

Ann, Oakley. A Feasibility study for a randomised controlled trial of daycare for preschool children. 2nd ed. Evidence in Policy & Practice Information & Coordinating Centre (EPPI Centre), 2002.

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14

J, Turner, and National Co-ordinating Centre for HTA (Great Britain), eds. A Randomised controlled trial of prehospital intravenous fluid replacement therapy in serious trauma. Alton: Core Research on behalf of the NCCHTA, 2000.

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15

J, Vickers A., and National Co-ordinating Centre for HTA (Great Britain), eds. Acupuncture of chronic headache disorders in primary care: Randomised controlled trial and economic analysis. Tunbridge Wells: Gray Publishing on behalf of NCCHTA, 2004.

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16

Early asthma prophylaxis, natural history, skeletal development and economy (EASE): A pilot randomised controlled trial. Alton: Core Research on behalf of the NCCHTA, 2000.

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17

C, Iglesias, and National Co-ordinating Centre for HTA (Great Britain), eds. VenUS 1: A randomised controlled trial of two types of bandage for treating venous leg ulcers. Tunbridge Wells: Gray Publishing on behalf of NCCHTA, 2004.

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18

A Randomised controlled trial to evaluate to effectiveness and cost-effectiveness of counselling patients with chronic depression. Alton: Core Research on behalf of the NCCHTA, 2000.

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19

S, Simpson, and National Co-ordinating Centre for HTA (Great Britain), eds. A Randomised controlled trial to evaluate the effectiveness and cost-effectiveness of counselling patients with chronic depression. Southampton: National Coordinating Centre for Health Technology Assessment, 2000.

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20

Group, Family Heart Study, ed. Randomised controlled trial evaluating cardiovascular screening and intervention in general practice: Principal results of British family heart study. [London]: British Medical Journal, 1994.

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21

G, Zermansky A., National Co-ordinating Centre for HTA (Great Britain), and Health Technology Assessment Programme, eds. Clinical medication review by a pharmacist of patients on repeat prescriptions in general practice: A randomised controlled trial. Alton: Core Research on behalf of the NCCHTA, 2002.

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22

Nightingale, Madeline, Rob Prideaux, Joanna Hofman, Nadja Koch, and Alex Sutherland. Wellbeing Premium randomised controlled trial for small and medium-sized enterprises: Recruitment evaluation report: Understanding factors influencing firms' recruitment. RAND Corporation, 2019. http://dx.doi.org/10.7249/rr2981.

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23

A, Elliott R., National Co-ordinating Centre for HTA (Great Britain), and Health Technology Assessment Programme, eds. Which anaesthetic agents are cost-effective in day surgery?: Literature review, national survey of practice and randomised controlled trial. ALton: Core Research on behalf of the NCCHTA, 2002.

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24

Hutton, Eileen K. McNally. The early external cephalic version (ECV) trial: A randomised controlled trial of ECV beginning at between 34 - 36 weeks compared to 37 - 38 weeks gestation. 2003.

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25

A Randomised controlled trial to evaluate the clinical and cost-effectiveness of Hickman line insertions in adult cancer patients by nurses. Tunbridge Wells: Gray Publishing, on behalf of the NCCHTA, 2003.

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26

Christine, McArthur, and National Co-ordinating Centre for HTA (Great Britain), eds. Redesigning postnatal care: A randomised controlled trial of protocol-based midwifery-led care focused on individual women's physical and psychological health needs. Tunbridge Wells: Gray Publishing, on behalf of NCCHTA, 2003.

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27

A Randomised controlled trial of a linkworker intervention to increase uptake of breast screening among Asian women: A report for Oldham Health Authority. Manchester: Centre for Cancer Epidemiology, University of Manchester, 1992.

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28

D, Kendrick, and National Co-ordinating Centre for HTA (Great Britain), eds. The Role of radiography in primary care patients with low back pain of at least 6 weeks duration: A randomised (unblinded) controlled trial. Alton: Core Research on behalf of the NCCHTA, 2001.

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29

M, Kennedy A. D., and National Co-ordinating Centre for HTA (Great Britain), eds. A multicentre randomised controlled trial assessing the costs and benefits of using structured information and analysis of women's preferences in the management of menorrhagia. Alton: Core Research on behalf of the NCCHTA, 2003.

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30

A Multicentre randomised controlled trial assessing the costs and benefits of using structures information and analysis of women's preferences in the management of menorrhagia. Southampton: NCCHTA, 2003.

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31

J, Gilbert F., and National Co-ordinating Centre for HTA (Great Britain), eds. Does early magnetic resonance imaging influence management or improve outcome in patients referred to secondary care with low back pain?: A pragmatic randomised controlled trial. Tunbridge Wells: Gray Publishing on behalf of NCCHTA, 2004.

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32

M, Simpson W., Health Technology Assessment Programme, Great Britain. Standing Group on Health Technology., National Co-ordinating Centre for HTA (Great Britain), and HTA Commissioning Board, eds. A Randomised controlled trial of different approaches to universal antenatal HIV testing, uptake and acceptability: And annex, Antenatal HIV testing - assessment of a routine voluntary approach. Alton: Core Research on behalf of NCCHTA, 1999.

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33

Goldby, Lucy. A randomised controlled trial comparing the McKenzie method of mechanical diagnosis and therapy with a non-prescriptiveexercise regime in the conservative treatment of chronic low back pain. UEL, 1994.

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34

J, McCarthy C., and National Co-ordinating Centre for HTA (Great Britain), eds. Supplementation of a home-based exercise programme with a class-based programme for people with osteoarthritis of the knees: A randomised controlled trial and health economic analysis. Tunbridge Wells: Gray Publishing on behalf of NCCHTA, 2004.

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35

H, Kinley, and National Co-ordinating Centre for HTA (Great Britain), eds. Extended scope of nursing practice: A multicentre randomised controlled trial of appropriately trained nurses and pre-registration house officers in pre-operative assessment in elective general surgery. Alton: Core research on behalf of NCCHTA, 2001.

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36

M, Wiggins, and Health technology assessment 2004, eds. The social support and family health study: A randomised controlled trial and economic evaluation of two alternative forms of postnatal support for mothers living in disadvantaged inner-city areas. Tunbridge Wells: Gray Publishing on behalf of NCCHTA, 2004.

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37

Routine examination of the newborn: the EMREN study: Evaluation of an extension of the midwife role including a randomised controlled trial of appropriately trained midwives and paediatric senior house officers. Tunbridge Wells: Gray Publishing on behalf of NCCHTA, 2004.

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38

C, Reeves B., and National Co-ordinating Centre for HTA (Great Britain), eds. A multi-centre randomised controlled trial of minimally invasive direct coronary bypass grafting versus percutaneous transluminal coronary angioplasty with stenting for proximal stenosis of the left anterior descending coronary artery. Tunbridge Wells: Gray Publishing on behalf of NCCHTA, 2004.

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39

Michael, King, and National Co-ordinating Centre for HTA (Great Britain), eds. Randomised controlled trial of non-directive counselling, cognitive-behaviour therapy and usual general practitioner care in the management of depression as well as mixed anxiety and depression in primary care. Alton: Core Research on behalf of the NCCHTA, 2000.

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40

Anne, Kennedy, National Co-ordinating Centre for HTA (Great Britain), and Health Technology Assessment Programme, eds. A Randomised controlled trial to assess the impact of a package comprising a patient-orientated, evidence-based self-help guidebook and patient-centred consultations on disease management and satisfaction in inflammatory bowel disease. Tunbridge Wells: Gray on behalf of the NCCHTA, 2003.

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41

Stewart, Robert. Vascular and mixed dementias. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199644957.003.0034.

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Vascular disease is the most important environmental risk factor for dementia but this research area has been hampered by inadequate outcome definitions – in particular, a diagnostic system that attempts to separate overlapping and probably interacting pathologies. There is now substantial evidence that the well-recognised risk factors for cardiovascular disease and stroke are also risk factors for dementia, including Alzheimer’s disease. However, these risk factors frequently act over several decades, meaning that the chances of definitive randomised controlled trial evidence for risk-modifying interventions are slim. This should not obscure the wide opportunity for delaying or preventing dementia through risk factor control and uncontroversial healthy lifestyles. Care should also be taken that comorbid cerebrovascular disease is not considered as excluding a diagnosis of Alzheimer’s disease, particularly now that this determines treatment eligibility.
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