Academic literature on the topic 'Randomised repeated measures'

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Journal articles on the topic "Randomised repeated measures"

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Froio de Araujo Dias, Gabriela, Vinicius da Eira Silva, Vitor de Salles Painelli, Craig Sale, Guilherme Giannini Artioli, Bruno Gualano, and Bryan Saunders. "(In)Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study." PLOS ONE 10, no. 11 (November 17, 2015): e0143086. http://dx.doi.org/10.1371/journal.pone.0143086.

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HANCOX, M. "The cattle TB crisis – a radical rethink." Journal of Agricultural Science 144, no. 2 (March 6, 2006): 187. http://dx.doi.org/10.1017/s0021859606005910.

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Cattle tuberculosis in Great Britain is out of control, rising at some 18% a year, but there is great confusion as to why cattle control measures are not working (Hancox 2004a). Culling over 10000 badgers so far in the Krebs Randomised Badger Culling Trial has had no effect, despite repeated calls for mass culls by farmers and vets (Hancox 2004b). Badgers are blamed for this crisis because it is claimed cattle-to-cattle transmission is unimportant, and badgers with TB are found after repeat breakdowns in herds supposedly free of TB after negative tests.
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Harnett, Joanna, Stephen P. Myers, and Margaret Rolfe. "Probiotics and the Microbiome in Celiac Disease: A Randomised Controlled Trial." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–16. http://dx.doi.org/10.1155/2016/9048574.

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Background. There is limited research investigating the composition of the gastrointestinal microbiota in individuals with celiac disease (CoeD) reporting only partial symptom improvement despite adherence to a strict gluten-free diet (GFD). The aim of this research was to determine if the gastrointestinal microbiota could be altered by probiotic bacteria and provide a potential new therapy for this subgroup.Methods. A multicentre RCT was conducted between January and August 2011 in Australia. Participants included 45 people with CoeD reporting only partial symptom improvement despite adherence to a strict GFD for a minimum of 12 months. Participants took 5 g of VSL#™probiotic formulation (n=23) or 5 g placebo (n=22) orally twice daily for 12 weeks. The main outcome measured was the efficacy of the probiotic formula in altering faecal microbiota counts between baseline and week 12. Safety was determined by safety blood and monitoring adverse events.Results. SPSS™multivariate repeated measures analysis (95th confidence level) revealed no statistically significant changes between the groups in the faecal microbiota counts or blood safety measures over the course of the study.Conclusion. The probiotic formula when taken orally over the 12-week period did not significantly alter the microbiota measured in this population. The trial was registered with Australian and New Zealand Clinical Trials RegisterACTRN12610000630011.
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Bonnin, C. M., C. Torrent, C. Arango, B. L. Amann, B. Solé, A. González-Pinto, J. M. Crespo, et al. "Functional remediation in bipolar disorder: 1-year follow-up of neurocognitive and functional outcome." British Journal of Psychiatry 208, no. 1 (January 2016): 87–93. http://dx.doi.org/10.1192/bjp.bp.114.162123.

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BackgroundFew randomised clinical trials have examined the efficacy of an intervention aimed at improving psychosocial functioning in bipolar disorder.AimsTo examine changes in psychosocial functioning in a group that has been enrolled in a functional remediation programme 1 year after baseline.MethodThis was a multicentre, randomised, rater-masked clinical trial comparing three patient groups: functional remediation, psychoeducation and treatment as usual over 1-year follow-up. The primary outcome was change in psychosocial functioning measured by means of the Functioning Assessment Short Test (FAST). Group×time effects for overall psychosocial functioning were examined using repeated-measures ANOVA (trial registration NCT01370668).ResultsThere was a significant group×time interaction for overall psychosocial functioning, favouring patients in the functional remediation group (F = 3.071, d.f. = 2, P = 0.049).ConclusionsImprovement in psychosocial functioning is maintained after 1-year follow-up in patients with bipolar disorder receiving functional remediation.
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Nolan, Hugh, John D. O'Connor, Orna A. Donoghue, George M. Savva, Neil O'Leary, and Rose-Anne Kenny. "Factors Affecting Reliability of Grip Strength Measurements in Middle Aged and Older Adults." HRB Open Research 3 (June 3, 2020): 32. http://dx.doi.org/10.12688/hrbopenres.13064.1.

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Background: Grip strength is a well-established marker of frailty and a good predictor of mortality that has been measured in a diverse range of samples including many population studies. The reliability of grip strength measurement in longitudinal studies is not well understood. Methods: Participants (n=130) completed a baseline and repeat health assessment in the Irish Longitudinal Study on Ageing. Grip strength was assessed using dominant and non-dominant hands (two trials on each). Repeat assessments were conducted 1-4 months later and participants were randomised into groups so that 50% changed time (morning or afternoon assessment) and 50% changed assessor between assessments. Intra-class correlation (ICC) and minimum detectable change (MDC95) were calculated and the effects of repeat assessment, time of day and assessor were determined. Results: Aggregated measures had little variation by repeat assessment or time of day; however, there was a significant effect of assessor (up to 2 kg depending on the measure used). Reliability between assessments was good (ICC>0.9) while MDC95 ranged from 5.59–7.96 kg. Non-aggregated measures alone, taken on the non-dominant hand were susceptible to repeat assessment, time of day, assessor and repeated measures within-assessment effects whereas the dominant hand was only affected by assessor. Conclusions: Mean and maximum grip strength had a higher ICC and lower MDC95 than measures on the dominant or non-dominant hands alone. The MDC95 is less than 8 kg regardless of the specific measure reported. However, changing assessor further increases variability, highlighting the need for comprehensive assessor training and avoiding changes within studies where possible.
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Rainey-Smith, Stephanie R., Belinda M. Brown, Hamid R. Sohrabi, Tejal Shah, Kathryn G. Goozee, Veer B. Gupta, and Ralph N. Martins. "Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults." British Journal of Nutrition 115, no. 12 (April 22, 2016): 2106–13. http://dx.doi.org/10.1017/s0007114516001203.

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AbstractCurcumin therapy in animals has produced positive cognitive and behavioural outcomes; results of human trials, however, have been inconsistent. In this study, we report the results of a 12-month, randomised, placebo-controlled, double-blind study that investigated the ability of a curcumin formulation to prevent cognitive decline in a population of community-dwelling older adults. Individuals (n 96) ingested either placebo or 1500 mg/d BiocurcumaxTM for 12 months. A battery of clinical and cognitive measures was administered at baseline and at the 6-month and 12-month follow-up assessments. A significant time×treatment group interaction was observed for the Montreal Cognitive Assessment (repeated-measures analysis; time×treatment; F=3·85, P<0·05). Subsequent analysis revealed that this association was driven by a decline in function of the placebo group at 6 months that was not observed in the curcumin treatment group. No differences were observed between the groups for all other clinical and cognitive measures. Our findings suggest that further longitudinal assessment is required to investigate changes in cognitive outcome measures, ideally in conjunction with biological markers of neurodegeneration.
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Best, Russ, Peter S. Maulder, and Nicolas Berger. "Perceptual and Physiological Responses to Carbohydrate and Menthol Mouth-Swilling Solutions: A Repeated Measures Cross-Over Preliminary Trial." Beverages 7, no. 1 (February 1, 2021): 9. http://dx.doi.org/10.3390/beverages7010009.

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Carbohydrate and menthol mouth-swilling have been used to enhance exercise performance in the heat. However, these strategies differ in mechanism and subjective experience. Participants (n = 12) sat for 60 min in hot conditions (35 °C; 15 ± 2%) following a 15 min control period, during which the participants undertook three 15 min testing blocks. A randomised swill (carbohydrate; menthol; water) was administered per testing block (one swill every three minutes within each block). Heart rate, tympanic temperature, thermal comfort, thermal sensation and thirst were recorded every three minutes. Data were analysed by ANOVA, with carbohydrate intake controlled for via ANCOVA. Small elevations in heart rate were observed after carbohydrate (ES: 0.22 ± 90% CI: −0.09–0.52) and water swilling (0.26; −0.04–0.54). Menthol showed small improvements in thermal comfort relative to carbohydrate (−0.33; −0.63–0.03) and water (−0.40; from −0.70 to −0.10), and induced moderate reductions in thermal sensation (−0.71; from −1.01 to −0.40 and −0.66; from −0.97 to −0.35, respectively). Menthol reduced thirst by a small to moderate extent. These effects persisted when controlling for dietary carbohydrate intake. Carbohydrate and water may elevate heart rate, whereas menthol elicits small improvements in thermal comfort, moderately improves thermal sensation and may mitigate thirst; these effects persist when dietary carbohydrate intake is controlled for.
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Pettilä, Ville, Pekka Leinonen, Antti Markkola, Vilho Hiilesmaa, and Risto Kaaja. "Postpartum Bone Mineral Density in Women Treated for Thromboprophylaxis with Unfractionated Heparin or LMW Heparin." Thrombosis and Haemostasis 87, no. 02 (2002): 182–86. http://dx.doi.org/10.1055/s-0037-1612970.

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SummaryVenous thromboembolism remains an important cause of maternal mortality. In a randomised open study, 44 pregnant women with confirmed previous or current thromboembolism were randomised to receive either low-molecular-weight heparin, dalteparin (N = 21) once daily subcutaneously or unfractionated sodium heparin (UF heparin, N = 23) twice daily subcutaneously for thromboprophylaxis during pregnancy and puerperium. Bone mineral density (BMD) in the lumbosacral spine was measured with dual X-ray absorptiometry (DEXA) 1, 6, 16, 52 weeks and, if possible, 3 years after delivery. BMD values were also compared with those of healthy, delivered women (N =19).Mean BMD of the lumbar spine was significantly lower in the unfractionated heparin group compared with the dalteparin and with the control groups (repeated measures ANOVA p = 0.02). BMD in the dalteparin group did not differ from BMD of healthy delivered women. Multiple logistic regression analysis revealed that therapy was the only independent factor influencing BMD at weeks 16 and 52. Therefore we recommend use of dalteparin instead of UF heparin for long-term thromboprophylaxis during and after pregnancy.
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Berk, Michael, Rothanthi Daglas, Orwa Dandash, Murat Yücel, Lisa Henry, Karen Hallam, Craig Macneil, et al. "Quetiapinev.lithium in the maintenance phase following a first episode of mania: Randomised controlled trial." British Journal of Psychiatry 210, no. 6 (June 2017): 413–21. http://dx.doi.org/10.1192/bjp.bp.116.186833.

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BackgroundLithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their efficacy compares with each other.AimsTo investigate the differential effect of lithium and quetiapine on symptoms of depression, mania, general functioning, global illness severity and quality of life in patients with recently stabilised first-episode mania.MethodMaintenance trial of patients with first-episode mania stabilised on a combination of lithium and quetiapine, subsequently randomised to lithium or quetiapine monotherapy (up to 800 mg/day) and followed up for 1 year. (Trial registration: Australian and New Zealand Clinical Trials Registry – ACTRN12607000639426.)ResultsIn total, 61 individuals were randomised. Within mixed-model repeated measures analyses, significant omnibus treatment × visit interactions were observed for measures of overall psychopathology, psychotic symptoms and functioning. Planned andpost hoccomparisons further demonstrated the superiority of lithium treatment over quetiapine.ConclusionsIn people with first-episode mania treated with a combination of lithium and quetiapine, continuation treatment with lithium rather than quetiapine is superior in terms of mean levels of symptoms during a 1-year evolution.
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Best, Russ, Dani Temm, Holly Hucker, and Kerin McDonald. "Repeated Menthol Mouth Swilling Affects Neither Strength nor Power Performance." Sports 8, no. 6 (June 17, 2020): 90. http://dx.doi.org/10.3390/sports8060090.

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This study aimed to assess the effects of repeated menthol mouth swilling upon strength and power performance. Nineteen (10 male) participants completed familiarisation and experimental trials of repeated menthol mouth swilling (0.1% concentration) or control (no swill) in a randomised crossover design. Participants performed an isometric mid-thigh pull (IMTP; peak and mean force; N), vertical jump (peak; cm) and six second sprint (peak and mean power; W) under each condition. Participants completed three efforts per exercise task interspersed with three-minute recoveries. Mean best values were analysed via a two-way mixed repeated measures ANOVA, and differences reported as effect sizes ± 95% confidence intervals, with accompanying descriptors and p values. Differences in peak IMTP values were unclear between familiarisation and experimental trials, and between menthol and control conditions. Mean IMTP force differed between familiarisation and control (0.51; −0.15 to 1.14; p = 0.001) and familiarisation and menthol conditions (0.50; −0.15 to 1.14; p = 0.002) by a small degree, but were unclear between control and menthol conditions. Unclear differences were also noted on vertical jump performance compared to familiarisation and between experimental conditions, with repeated six second peak and average power performance also showing unclear effects across all comparisons. We conclude that repeated menthol mouth swilling does not improve strength or power performance.
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Dissertations / Theses on the topic "Randomised repeated measures"

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Walters, Kimberly Ann. "The Use Of Post-Intervention Data From Waitlist Controls To Improve Estimation Of Treatment Effect In Longitudinal Randomized Controlled Trials." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218445774.

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Montgomery, Trevor. "The effects of sagittal plane postures on trunk rotation range of motion." 2008. http://hdl.handle.net/10292/392.

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Axial rotation is regarded as an essential movement of the trunk that allows many individuals to participate in vocations, sports and activities of daily living. Unfortunately when the destabilising nature of rotation is combined with that of spinal flexion, the risk of injuring the spine can increase significantly. Few studies have investigated the potential benefits that maximizing trunk rotation has in certain vocation and sport-related arenas and none have looked at whether adopting certain spinal postures in the sagittal plane can maximise trunk rotation more than others. The aim of the study was to determine the effects of alterations of trunk inclination, spinal posture, pelvic fixation and turning direction on the active range of motion (ROM) of trunk rotation. Twenty healthy individuals participated in the main study. Retro-reflective markers were placed on key anatomical locations and used to track the movement of the thorax and pelvis during a series of repeated maximal trunk rotations in ten different spinal positions within the sagittal plane. Trunk kinematics and kinetics were recorded simultaneously using an optoelectronic motion analysis and force platform measuring system. A repeated-measures multiple analysis of variance (MANOVA) was used to test for the main effects of trunk inclination, spinal posture, fixation of pelvis and direction of turn on maximum active ROM of trunk rotation, maximum pelvic rotation and the anterior-posterior and lateral displacement of the centre of pressure (COP). To investigate test-retest reliability, ten participants were tested on two separate days. Repeatability for each outcome measure was investigated using interclass correlation coefficients (ICC) and Bland Altman graphs. The majority of subjects showed reasonable test-retest reliability for trunk rotation measures in each of the test positions, with ICC’s ranging between 0.562 – 0.731. Overall, trunk inclination (0°, 22.5°, 45°) forward in the sagittal plane had a significant effect on trunk and pelvic rotation (p<0.001) and lateral displacement of the COP (p<0.005) during trunk rotation. As trunk inclination increased from 0° to 45° there was an average increase in trunk rotation ROM of approximately 10 % (approximately 3.4°). Furthermore, increasing trunk inclination led to an increase in lateral displacement of the COP and a decrease in pelvic rotation. Spinal posture (neutral, flexed, extended) at a forward inclination of 45° had a significant effect on trunk rotation (p<0.01) and pelvic rotation (p<0.05), with a neutral spine averaging approximately 3 % (approximately 1.1°) more trunk rotation than a flexed or extended posture. The position and posture of the spine in the sagittal plane appears to have a significant influence on ranges of trunk rotation. The study suggests that rotating the trunk when adopting a neutral spine inclined to 45° will maximise range of trunk rotation and encourage a natural stabilisation of the lower body. This posture meets the unique set of biomechanical requirements for the sport of golf and may help to reduce the risk of injury in manual material handling tasks. Conversely, rotating the trunk whilst the thoracolumbar spine is flexed leads to a reduction in trunk rotation ROM, encourages greater pelvic and lower body rotation, reduces torque production of the trunk and may increase the risk of lower back injury. These findings have important implications in relation to the teaching of spinal position during vocations, sports and activities of daily living that seek to maximise trunk rotation.
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Books on the topic "Randomised repeated measures"

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Tango, Toshiro. Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials. Chapman and Hall/CRC, 2017. http://dx.doi.org/10.1201/9781315152097.

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Book chapters on the topic "Randomised repeated measures"

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"Repeated-Measures and Randomized Block Designs." In Randomization Tests, 133–74. Chapman and Hall/CRC, 2007. http://dx.doi.org/10.1201/9781420011814-12.

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"Unreplicated Factorial Designs - Randomized Block and Simple Repeated Measures." In Biostatistical Design and Analysis Using R, 360–98. Oxford, UK: Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9781444319620.ch13.

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"Randomized blocks and simple repeated measures: unreplicated two factor designs." In Experimental Design and Data Analysis for Biologists, 262–300. Cambridge University Press, 2002. http://dx.doi.org/10.1017/cbo9780511806384.011.

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Leibovici, Leonard, and Mical Paul. "Replication and Repetition in Systematic Reviews and Meta-analyses in Medicine." In Stepping in the Same River Twice. Yale University Press, 2017. http://dx.doi.org/10.12987/yale/9780300209549.003.0011.

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This chapter discusses systematic reviews (SRs) and meta-analysis (MA). SRs are reviews of the “best available,” reliable studies focused on a specific research question. Most often, the studies included in SRs are randomized controlled trials (RCTs) that have repeated the same treatments in (usually) different situations. MA is a statistical method applied to the results gleaned from an SR that yields a single measure of the expected outcomes of repeated trials, along with an assertion of the confidence we have in that measure. This chapter argues that RCTs are never similar enough to be considered identical replicates, but they are repeated studies, usually on different populations. Comparable RCTs examine one or similar outcomes (based on a hypothesized cause-and-effect relationship), which is why comparable RCTs can be included in SRs and MAs. If SRs and MAs show convincing results, further repeated RCTs would be avoided, thus saving valuable resources. However, evidence to date suggests that this rarely occurs.
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"Studies With Multiple Observations for Each Subject: Repeated Measures and Multivariate Analyses Randomized Block ANOVA: An Introduction to Repeated-." In Statistical Power Analysis, 153–67. Routledge, 2014. http://dx.doi.org/10.4324/9781315773155-14.

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Muthé N, Bengt, and Hendricks C. Brown. "General Approaches to Analysis of Course: Applying Growth Mixture Modeling to Randomized Trials of Depression Medication." In Causality and Psychopathology. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199754649.003.0012.

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This chapter discusses the assessment of treatment effects in longitudinal randomized trials using growth mixture modeling (GMM) (Muthén & Shedden, 1999; Muthén & Muthén, 2000; Muthén et al., 2002; Muthén & Asparouhov, 2009). GMM is a generalization of conventional repeated measurement mixed-effects (multilevel) modeling. It captures unobserved subject heterogeneity in trajectories not only by random effects but also by latent classes corresponding to qualitatively different types of trajectories. It can be seen as a combination of conventional mixed-effects modeling and cluster analysis, also allowing prediction of class membership and estimation of each individual’s most likely class membership. GMM has particularly strong potential for analyses of randomized trials because it responds to the need to investigate for whom a treatment is effective by allowing for different treatment effects in different trajectory classes. The chapter is motivated by a University of California, Los Angeles study of depression medication (Leuchter, Cook, Witte, Morgan, & Abrams, 2002). Data on 94 subjects are drawn from a combination of three studies carried out with the same design, using three different types of medications: fluoxetine (n = 14), venlafaxine IR (n = 17), and venlafaxine XR (n = 18). Subjects were measured at baseline and again after a 1-week placebo lead-in phase. In the subsequent double-blind phase of the study, the subjects were randomized into medication (n = 49) and placebo (n = 45) groups. After randomization, subjects were measured at nine occasions: at 48 hours and at weeks 1–8. The current analyses consider the Hamilton Depression Rating Scale. Several predictors of course of the Hamilton scale trajectory are available, including gender, treatment history, and a baseline measure of central cordance hypothesized to influence tendency to respond to treatment. The results of studies of this kind are often characterized in terms of an end point analysis where the outcome at the end of the study, here at 8 weeks, is considered for the placebo group and for the medication group.
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Conference papers on the topic "Randomised repeated measures"

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Jahani, Nazanin, Joaquín Ambía, Kristian Fossum, Sergey Alyaev, Erich Suter, and Carlos Torres-Verdín. "REAL-TIME ENSEMBLE-BASED WELL-LOG INTERPRETATION FOR GEOSTEERING." In 2021 SPWLA 62nd Annual Logging Symposium Online. Society of Petrophysicists and Well Log Analysts, 2021. http://dx.doi.org/10.30632/spwla-2021-0105.

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The cost of drilling wells on the Norwegian Continen-tal Shelf are extremely high, and hydrocarbon reservoirs are often located in spatially complex rock formations. Optimized well placement with real-time geosteering is crucial to efficiently produce from such reservoirs and reduce exploration and development costs. Geosteering is commonly assisted by repeated formation evaluation based on the interpretation of well logs while drilling. Thus, reliable computationally efficient and robust work-flows that can interpret well logs and capture uncertain-ties in real time are necessary for successful well place-ment. We present a formation evaluation workflow for geosteering that implements an iterative version of an ensemble-based method, namely the approximate Leven-berg Marquardt form of the Ensemble Randomized Max-imum Likelihood (LM-EnRML). The workflow jointly estimates the petrophysical and geological model param-eters and their uncertainties. In this paper the demon-strate joint estimation of layer-by-layer water saturation, porosity, and layer-boundary locations and inference of layers’ resistivities and densities. The parameters are estimated by minimizing the statistical misfit between the simulated and the observed measurements for several logs on different scales simultaneously (i.e., shallow-sensing nuclear density and shallow to extra-deep EM logs). Numerical experiments performed on a synthetic exam-ple verified that the iterative ensemble-based method can estimate multiple petrophysical parameters and decrease their uncertainties in a fraction of time compared to clas-sical Monte Carlo methods. Extra-deep EM measure-ments are known to provide the best reliable informa-tion for geosteering, and we show that they can be in-terpreted within the proposed workflow. However, we also observe that the parameter uncertainties noticeably decrease when deep-sensing EM logs are combined with shallow sensing nuclear density logs. Importantly the es-timation quality increases not only in the proximity of the shallow tool but also extends to the look ahead of the extra-deep EM capabilities. We specifically quantify how shallow data can lead to significant uncertainty re-duction of the boundary positions ahead of bit, which is crucial for geosteering decisions and reservoir mapping.
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