Academic literature on the topic 'Randomized Controlled Trial Design'

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Journal articles on the topic "Randomized Controlled Trial Design"

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Dohoo, Ian R. "The design of randomized controlled trials of veterinary vaccines." Animal Health Research Reviews 5, no. 2 (2004): 235–38. http://dx.doi.org/10.1079/ahr200474.

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AbstractRandomized controlled trials of veterinary vaccines are essential if we are to have a reasonable understanding of how those vaccines can be expected to perform when used in the field. This manuscript reviews a few (but certainly not all) of the key elements that need to be considered in the design of veterinary vaccine trials. The first step in the design of such a trial is to have a clear statement of the objective of the trial that reflects what is expected of the vaccine (e.g. should it minimize clinical disease or does it need to prevent infection?). Because domestic animals are of
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van der Baan, Frederieke H., Olaf H. Klungel, Antoine CG Egberts, et al. "Pharmacogenetics in randomized controlled trials: considerations for trial design." Pharmacogenomics 12, no. 10 (2011): 1485–92. http://dx.doi.org/10.2217/pgs.11.95.

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NAVANEETHAN, SANKAR D., SUETONIA C. PALMER, ALICIA SMITH, DAVID W. JOHNSON, and GIOVANNI FM STRIPPOLI. "How to design a randomized controlled trial." Nephrology 15, no. 8 (2010): 732–39. http://dx.doi.org/10.1111/j.1440-1797.2010.01428.x.

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Badian, Reza A., Brendan McCormack, and Vibeke Sundling. "Person-Centered Research: A novel approach to Randomized Controlled Trials." European Journal for Person Centered Healthcare 6, no. 2 (2018): 209. http://dx.doi.org/10.5750/ejpch.v6i2.1435.

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Introduction: Integrating person-centered values with randomized controlled trials methodology is a novel idea. Person-centeredness is gaining steadily more prominence and attention in healthcare and health-related policy and research. Randomized controlled trials are considered as the gold standard in evidence-based medicine for evaluating the effects of treatment or determining the causal effect. A wide array of study designs is available, but there is a lack of designs with both strong person-centered principles and a strong position with respect to the level of evidence. In this paper we i
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Hannon, Peggy A., Kristen Hammerback, Claire L. Allen, et al. "HealthLinks randomized controlled trial: Design and baseline results." Contemporary Clinical Trials 48 (May 2016): 1–11. http://dx.doi.org/10.1016/j.cct.2016.02.011.

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Bailey, Julia V., Menelaos Pavlou, Andrew Copas, et al. "The Sexunzipped Trial: Optimizing the Design of Online Randomized Controlled Trials." Journal of Medical Internet Research 15, no. 12 (2013): e278. http://dx.doi.org/10.2196/jmir.2668.

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Uveges, Melissa Kurtz, Dina George Lansey, Olive Mbah, Tamryn Gray, Lisa Sherden, and Jennifer Wenzel. "Patient navigation and clinical trial participation: A randomized controlled trial design." Contemporary Clinical Trials Communications 12 (December 2018): 98–102. http://dx.doi.org/10.1016/j.conctc.2018.09.003.

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Purgato, Marianna, Corrado Barbui, and Andrea Cipriani. "Assessing risk of bias in randomized controlled trials." Epidemiology and Psychiatric Sciences 19, no. 4 (2010): 296–97. http://dx.doi.org/10.1017/s1121189x00000622.

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AbstractEven though randomised controlled trials are the design of choice for evaluating the efficacy of health care interventions, they are not immune to bias that may affect research process and validity of results. In the present paper we discussed how trial quality may be appraised considering both whether a clinical trial is reported in a comprehensive and complete way (consistently with what had been declared in the study protocol), and whether the characteristics of the trial itself are associated with risk of bias.
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Jones, Mark, Val Gebski, Mark Onslow, and Ann Packman. "Design of randomized controlled trials." Journal of Fluency Disorders 26, no. 4 (2001): 247–67. http://dx.doi.org/10.1016/s0094-730x(01)00108-5.

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Stanley, Kenneth. "Design of Randomized Controlled Trials." Circulation 115, no. 9 (2007): 1164–69. http://dx.doi.org/10.1161/circulationaha.105.594945.

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Dissertations / Theses on the topic "Randomized Controlled Trial Design"

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Spieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Dove Medical Press, 2016. https://tud.qucosa.de/id/qucosa%3A29007.

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Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle of equipoise and its practical applicability to clinical science with an emphasis on critical care and neurological research. We performed a review of educational material, review articles, methodological studies, and published clinical trials u
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Spieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-215848.

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Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle of equipoise and its practical applicability to clinical science with an emphasis on critical care and neurological research. We performed a review of educational material, review articles, methodological studies, and published clinical trials u
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Reichmann, William Michael. "Methods in subgroup analysis: estimation of risk and implications for randomized controlled trial design." Thesis, Boston University, 2012. https://hdl.handle.net/2144/32047.

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Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Estimation of exposure-specific risks (ESRs) using estimates of the overall risk and relative risk of disease given exposure has been performed in previous studies, but the performance of such an estimator ha
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Vixner, Linda, Lena B. Mårtensson, Elisabet Stener-Victorin, and Erica Schytt. "Manual and electroacupuncture for labour pain : study design of a longitudinal randomized controlled trial." Högskolan Dalarna, Medicinsk vetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:du-10073.

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Introduction. Results from previous studies on acupuncture for labour pain are contradictory and lack important information on methodology. However, studies indicate that acupuncture has a positive effect on women's experiences of labour pain. The aim of the present study was to evaluate the efficacy of two different acupuncture stimulations, manual or electrical stimulation, compared with standard care in the relief of labour pain as the primary outcome. This paper will present in-depth information on the design of the study, following the CONSORT and STRICTA recommendations. Methods. The stu
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Ware, Lorraine, Tatsuki Koyama, Dean Billheimer, et al. "Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial." BioMed Central, 2011. http://hdl.handle.net/10150/610331.

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BACKGROUND:Given the persistent shortage of organs for transplantation, new donor management strategies to improve both organ utilization and quality of procured organs are needed. Current management protocols for the care of the deceased donor before organ procurement are based on physiological rationale, experiential reasoning, and retrospective studies without rigorous testing. Although many factors contribute to the lack of controlled clinical trials in donor management, a major factor is the unique challenges posed by research in the brain-dead organ donor.METHODS AND RESULTS:This article
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Dunn, Rose. "Using Pre-Session Mindfulness to Improve Session Presence and Effectiveness: A Randomized-Controlled Trial." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc862760/.

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While a significant amount of research illustrates the overall positive effects of therapists' general use of mindfulness, very few studies have addressed whether therapists' use of mindfulness translates to improved psychotherapy outcomes. The present study utilized a randomized-controlled design to test whether a brief mindfulness training program and pre-session mindfulness practice could have a positive impact on therapy; in particular, we hypothesized that mindfulness training and practice would improve ratings on therapeutic presence as rated by clients and therapists and session effect
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Orr, Serena. "The Pharmacologic Prophylaxis of Pediatric Migraine: A Systematic Review, Survey and Design of a Randomized Controlled Trial." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35109.

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Objectives: 1) To describe the state of the evidence for interventions in pediatric migraine, 2) to survey experts regarding non-inferiority margins in migraine research and 3) to design a clinical trial in this area of research. Methods: A systematic review was carried out to identify randomized, placebo-controlled trials of pharmaceutical and nutraceutical interventions used to prevent migraine in children and adolescents, using Cochrane methods. Secondly, neurologists with expertise in Headache Medicine were invited to participate in a survey regarding their opinions on non-inferiority m
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Ben, Rahal Gahda B. S. [Verfasser], and Ralf-Joachim [Akademischer Betreuer] Kohal. "Evaluation of two different implant designs: preliminary results of a randomized controlled equivalence trial." Freiburg : Universität, 2020. http://d-nb.info/1221061429/34.

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Bell, Melanie L., Amy L. Whitehead, and Steven A. Julious. "Guidance for using pilot studies to inform the design of intervention trials with continuous outcomes." DOVE MEDICAL PRESS LTD, 2018. http://hdl.handle.net/10150/627081.

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Background: A pilot study can be an important step in the assessment of an intervention by providing information to design the future definitive trial. Pilot studies can be used to estimate the recruitment and retention rates and population variance and to provide preliminary evidence of efficacy potential. However, estimation is poor because pilot studies are small, so sensitivity analyses for the main trial's sample size calculations should be undertaken. Methods: We demonstrate how to carry out easy-to-perform sensitivity analysis for designing trials based on pilot data using an example. F
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Dakin, Helen A. "Economic evaluation of factorial randomised controlled trials." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:77eda1f6-dd8c-439a-8871-75fd57a4c7f5.

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Factorial randomised controlled trials (RCTs) evaluate two or more interventions simultaneously, enabling assessment of interactions between treatments. This thesis presents literature reviews, methodological reviews, simulation studies and applied case studies that explore methods for assessing cost-effectiveness based on factorial RCTs. My systematic review suggests that factorial RCTs account for around 3% of trial-based economic evaluations, although there is currently no guidance or methodological work indicating the most appropriate methods. Around 40% of published studies assumed no int
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Books on the topic "Randomized Controlled Trial Design"

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Matthews, J. N. S. An introduction to randomized controlled clinical trials. Arnold, 2000.

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Machin, David. Randomized clinical trials: Design, practice, and reporting. John Wiley & Sons, 2010.

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Machin, David. Randomized clinical trials: Design, practice and reporting. Wiley-Blackwell, 2010.

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M, Cavanaugh Mary, and Draine Jeffrey, eds. Randomized controlled trials: Design and implementation for community-based psychosocial interventions. Oxford University Press, 2009.

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Randomized clinical trials of nonpharmacologic treatments. Chapman and Hall/CRC, 2012.

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Modern adaptive randomized clinical trials: Statistical and practical aspects. Taylor & Francis, 2015.

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Neil, Klar, ed. Design and analysis of cluster randomization trials in health research. Arnold, 2000.

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Campbell, Michael J. How to design, analyse and report cluster randomised trials in medicine and health related research. John Wiley & Sons, 2014.

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Randomised controlled clinical trials. 2nd ed. Kluwer Academic Publishers, 1996.

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Everitt, Brian. Clinical trials in psychiatry. Oxford University Press, 2004.

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Book chapters on the topic "Randomized Controlled Trial Design"

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Curtis, Bryan M., Brendan J. Barrett, and Patrick S. Parfrey. "Randomized Controlled Trials 1: Design." In Methods in Molecular Biology. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2428-8_9.

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Pahor, Marco, and Matteo Cesari. "Study Design: Randomized Controlled Trials." In The Epidemiology of Aging. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-5061-6_3.

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Curtis, Bryan M., Brendan J. Barrett, and Patrick S. Parfrey. "Randomized Controlled Trials 1: Design." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1138-8_11.

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Curtis, Bryan M., Brendan J. Barrett, and Patrick S. Parfrey. "The Design of Randomized Controlled Trials." In Clinical Epidemiology. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-385-1_5.

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Sjöström, Jonas, and Mohammad Hafijur Rahman. "Designing Software for Online Randomized Controlled Trials." In The Next Wave of Sociotechnical Design. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82405-1_21.

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Butler, Emily, and Michael Kosorok. "Design and Analysis Methods for Developing Personalized Treatment Rules." In Handbook of Statistical Methods for Randomized Controlled Trials. Chapman and Hall/CRC, 2021. http://dx.doi.org/10.1201/9781315119694-22.

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Bolognese, James A., and Yevgen Tymofyeyev. "Case Study: Design Considerations for a Phase Ib Randomized, Placebo-Controlled, 4-Period Crossover Adaptive Dose-Finding Clinical Trial." In Practical Considerations for Adaptive Trial Design and Implementation. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1100-4_18.

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Chui, Raymond Chi Fai, Nicolson Yat-Fan Siu, Wai-Man Tsui, and Chloe Yuet-Tung Wong. "The Efficacy of the Mobile Application-Based Mindfulness Mediation on Adjustment of College Students in Hong Kong: A Randomized Controlled Trial." In Learning Environment and Design. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-8167-0_14.

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Bulpitt, Christopher J. "Different Trial Designs." In Randomised Controlled Clinical Trials. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_5.

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Masters, Kevin S. "Randomized Controlled Trial." In Encyclopedia of Sciences and Religions. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-1-4020-8265-8_200344.

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Conference papers on the topic "Randomized Controlled Trial Design"

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McIntyre, Lauralyn A., Alexis Turgeon, Robert Green, et al. "The PRECISE Fluid Resuscitation Pilot Randomized Controlled Trial: Study Design And Preliminary Feasibility Results." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6038.

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Xu, Danlin, Kenechi Ejebe, Vissia Viglietta, et al. "F39 Design of an adaptive randomized controlled phase 1B/2A trial of WVE-003 in participants with huntington’s disease." In EHDN Abstracts 2021. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/jnnp-2021-ehdn.82.

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Novitasari, Elisa, RB Soemanto, and Hanung Prasetya. "Acupuncture Therapy in Reducing Pain in Patients with Low Back Pain: Meta Analysis." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.43.

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ABSTRACT Background: With growing evidence of high prevalence in developing countries, LBP is no longer recognized as a disorder confined to high-income nations but is a major health problem globally. The functional limitations and consequent disability create a heavy economic burden on individuals and society. This study aimed to acupuncture therapy in reducing pain in patients with low back pain. Subjects and Method: A meta-analysis and systematic review was conducted by search published articles from PubMed, Google Schoolar, Mendeley, Hindawi, and Clinical key databases. Keywords used “acup
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Fatati, Muhibbah, Setyo Sri Rahardjo, and Hanung Prasetya. "Lateral Wedge Insole Uptake in Reducing Pain in Patients with Knee Osteoarthritis: A Meta-Analysis Study." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.45.

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ABSTRACT Background: The increase in rates of knee replacement for osteoarthritis has made the identification of effective nonsurgical treatments a high priority. One type of treatment for medial knee osteoarthritis involves reducing medial loading to ease the physical stress applied to that compartment of the joint. The wedge is placed under the sole of the foot and angulated so that it is thicker over the lateral than the medial edge, transferring loading during weight bearing from the medial to the lateral knee compartment. This study aimed to investigate the effect of lateral wedge insole
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El Hajj, Maguy, Ahmed Awaisu, Nadir Kheir, et al. "Evaluation of an Intensive Education Program on the Treatment of Tobacco-use Disorder for Pharmacists: A Randomized Controlled Trial." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0112.

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Tobacco use is one of the main causes of premature deaths and preventable diseases in Qatar. The aim of this randomized controlled trial (RCT) is to design, implement, and evaluate an intensive education program on tobacco-use treatment for pharmacists in Qatar. The study objectives are to assess the effectiveness of the program on pharmacists’ knowledge, skills, attitudes and perceived self-efficacy toward tobacco cessation. Methods: Community pharmacists practicing in Qatar were eligible for participation in the study. Consenting participants were randomly allocated to intervention or contro
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Setiawan, Cahyo, Didik Gunawan Tamtomo, and Hanung Prasetya. "Effect of Kinesiology Taping in Reducing Pain in Patients with Low Back Pain: A Meta Analysis." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.60.

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Background: Kinesiology taping is a therapeutic tool for the prevention and treatment of sporting injuries. It was developed to alleviate pain and improve the healing in soft tissues. This study aimed to examine effect of kinesiology taping in reducing pain in patients with low back pain. Subjects and Method: This was a meta-analysis and systematic review. The study was conducted by collecting published articles from PubMed, Science Direct, and Google Scholar databases. Keywords used “kinesio taping” OR “kinesio tape” OR “pain” OR “Low Back Pain” AND “Randomized Controlled Trial”. The study po
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Anggriani, Atika Febri, Agus Kristiyanto, and Setyo Sri Rahardjo. "A Meta-Analysis of Knee Orthosis Uptake in Reducing Pain in Patients with Knee Osteoarthritis." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.44.

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ABSTRACT Background: Osteoarthritis (OA) of knee joint is a degenerative disease that results in decreased function and pain. Orthotic devices can reduce knee adduction moment, pain, and improve function in knee OA. The purpose of this study was to examine knee orthosis uptake in reducing pain in patients with knee osteoarthritis. Subjects and Method: A meta-analysis and systematic review was conducted by search published articles from PubMed, Science Direct, Google Sscholar, Mendeley, and Clinical key databases. Keywords used “knee orthosis” OR “KO” AND “valgus knee brace” AND “brace” AND “kn
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Young, L., K. K. Brown, M. Griese, et al. "Study Design of a Phase III, Randomized, Placebo-Controlled Trial of Nintedanib in Children and Adolescents with Clinically Significant Fibrosing Interstitial Lung Disease (ILD)." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1495.

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Ishihara, Hiroyuki, Hideaki Hida, Mitsuaki Machida, Yoshiyuki Tsuda, and Sayaka Miyazaki. "Design of phase 2b randomised controlled trial of S-600918, P2X3 receptor antagonist for refractory chronic cough." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.2271.

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Susilo, Fahmi Eko, Hanung Prasetya, and Agus Kristiyanto. "Meta-Analysis: Acupuncture Therapy in Reducing Blood Pressure on Hypertensive Patients." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.53.

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Background: Blood pressure control is an important component of cardiovascular disease prevention. Despite the advances in the treatment of hypertension; effective management remains poor. Studies have shown that acupuncture facilitated a significant reduction in blood pressure. The purpose of this study was to examine the effectiveness of acupuncture therapy in reducing blood pressure on hypertensive patients. Subjects and Method: This was a meta-analysis and systematic review. The study was conducted by collected articles from PubMed, Google Schoolar, Mendeley, and Hindawi databases. Keyword
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Reports on the topic "Randomized Controlled Trial Design"

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Deo, Salil, David McAllister, Naveed Sattar, and Jill Pell. The time-varying cardiovascular benefits of glucagon like peptide-1 agonist (GLP-RA)therapy in patients with type 2 diabetes mellitus: A meta-analysis of multinational randomized trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.7.0097.

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Review question / Objective: P - patients with type 2 diabetes melllitus already receiving routine medical therapy; I - patients receiving glucagon like peptide 1 receptor agonist (GLP1 receptor agonist) therapy (semaglutide, dulaglutide, liraglutide, exenatide, lixisenatide, efpeglenatide, abiglutide); C - patients receiving standard therapy for diabetes mellitus but not receiving GLP1 agonist therapy; O - composite end point as per invididual trial, cardiovascular mortality, all-cause mortality, myocardial infarction, stoke. Condition being studied: Type 2 diabetes mellitus. Study designs to
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Patton, Amy, Kylie Dunavan, Kyla Key, Steffani Takahashi, Kathryn Tenner, and Megan Wilson. Reducing Stress, Anxiety, and Depression for NICU Parents. University of Tennessee Health Science Center, 2021. http://dx.doi.org/10.21007/chp.mot2.2021.0012.

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This project aims to appraise evidence of the effectiveness of various practices on reducing stress, anxiety, and depression among parents of infants in the neonatal intensive care unit (NICU). The project contains six research articles from both national and international journals. Study designs include one meta-analysis, one randomized controlled trial, one small scale randomized controlled trial, one prospective phase lag cohort study, on pretest-posttest study, and one mixed-methods pretest-posttest study. Recommendations for effective interventions were based on best evidence discovered t
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Ruzek, Josef. Randomized, Controlled Trial of CBT Training for PTSD Providers. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada593743.

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Moss, David, Paul Crawford, Heather Pickett, and Eric Abbott. Ear Acupuncture for Acute Sore Throat: A Randomized Controlled Trial. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada610454.

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Luxton, David D., Nigel Bush, Gregory Gahm, et al. Caring Letters for Military Suicide Prevention: A Randomized Controlled Trial. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada614508.

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Luxton, David, Nigel Bush, Gregory Gahm, et al. Caring Letters for Military Suicide Prevention: A Randomized Controlled Trial. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada574923.

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Luxton, David. Caring Letters for Military Suicide Prevention: A Randomized Controlled Trial. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada596676.

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Roy, Michael J. Randomized, Controlled Trial of Combination Treatment With Pyridostigmine, DEET, and Teremethrin. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada446574.

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Erickson, Jay. A Randomized Controlled Trial of Medical Therapies for Chronic Post-Traumatic Headaches. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada503819.

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Erickson, Jay. A Randomized Controlled Trial of Medical Therapies for Chronic Post-Traumatic Headaches. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada562926.

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