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Dissertations / Theses on the topic 'Randomized design'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Spieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-215848.

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Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle of equipoise and its practical applicability to clinical science with an emphasis on critical care and neurological research. We performed a review of educational material, review articles, methodological studies, and published clinical trials u

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Spieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Dove Medical Press, 2016. https://tud.qucosa.de/id/qucosa%3A29007.

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Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle of equipoise and its practical applicability to clinical science with an emphasis on critical care and neurological research. We performed a review of educational material, review articles, methodological studies, and published clinical trials u

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3

Xu, Bo. "Predictors of treatment means for a one factor completely randomized design." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/dissertations/AAI3372284/.

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4

Asmus, Josefine. "An Efficient Randomized Approximation Algorithm for Volume Estimation and Design Centering." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226664.

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Die Konstruktion von Systemen oder Modellen, welche unter Unsicherheit und Umweltschwankungen robust arbeiten, ist eine zentrale Herausforderung sowohl im Ingenieurwesen als auch in den Naturwissenschaften. Dies ist im Design-Zentrierungsproblem formalisiert als das Finden eines Designs, welches vorgegebene Spezifikationen erfüllt und dies mit einer hohen Wahrscheinlichkeit auch noch tut, wenn die Systemparameter oder die Spezifikationen zufällig schwanken. Das Finden des Zentrums wird oft durch das Problem der Quantifizierung der Robustheit eines Systems begleitet. Hier stellen wir eine neue

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5

Dunning, Andrew J. "Aspects of matching and power in group randomized trials /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9592.

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You, Zhiying. "Power and sample size of cluster randomized trials." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/you.pdf.

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7

Shen, Zuchao. "Optimal Sample Allocation in Multilevel Experiments." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553528863915366.

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8

Sun, Yiping. "Rank-sum test for two-sample location problem under order restricted randomized design." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180147276.

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9

Dong, Ranran. "Stepped Wedge Cluster Randomized Controlled Trials for Three-Level Data: Design and Evaluation." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1514492341281384.

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10

Boyd, Felicity T. "Methods of learning in statistical education design and analysis of a randomized trial /." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3080628.

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11

Reichmann, William Michael. "Methods in subgroup analysis: estimation of risk and implications for randomized controlled trial design." Thesis, Boston University, 2012. https://hdl.handle.net/2144/32047.

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Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Estimation of exposure-specific risks (ESRs) using estimates of the overall risk and relative risk of disease given exposure has been performed in previous studies, but the performance of such an estimator ha

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12

Yoders, Samuel A. "Integration of Simulation into Healthcare Education through Applied Constructivism: A Randomized, Switching Replications Experiment." NSUWorks, 2017. http://nsuworks.nova.edu/gscis_etd/1002.

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This report describes the development, deployment, and analysis of an experimental instructional unit using applied constructivism instructional design (ID). The ID template was used to integrate a high-fidelity simulator into an undergraduate health care degree curriculum in a private, not-for-profit university. A switching-replications experimental design was used with random assignment of volunteer participants to initial treatment and control groups. Quantitative analysis of learning outcomes using standardized assessments was performed, including correlational analysis for knowledge trans

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Vixner, Linda, Lena B. Mårtensson, Elisabet Stener-Victorin, and Erica Schytt. "Manual and electroacupuncture for labour pain : study design of a longitudinal randomized controlled trial." Högskolan Dalarna, Medicinsk vetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:du-10073.

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Introduction. Results from previous studies on acupuncture for labour pain are contradictory and lack important information on methodology. However, studies indicate that acupuncture has a positive effect on women's experiences of labour pain. The aim of the present study was to evaluate the efficacy of two different acupuncture stimulations, manual or electrical stimulation, compared with standard care in the relief of labour pain as the primary outcome. This paper will present in-depth information on the design of the study, following the CONSORT and STRICTA recommendations. Methods. The stu

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Ware, Lorraine, Tatsuki Koyama, Dean Billheimer, et al. "Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial." BioMed Central, 2011. http://hdl.handle.net/10150/610331.

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BACKGROUND:Given the persistent shortage of organs for transplantation, new donor management strategies to improve both organ utilization and quality of procured organs are needed. Current management protocols for the care of the deceased donor before organ procurement are based on physiological rationale, experiential reasoning, and retrospective studies without rigorous testing. Although many factors contribute to the lack of controlled clinical trials in donor management, a major factor is the unique challenges posed by research in the brain-dead organ donor.METHODS AND RESULTS:This article

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15

Osafo, Mamfe. "Nonparametric Test for Nondecreasing Order Alternatives in Randomized Complete Block and Balanced Incomplete Block Mixed Design." Diss., North Dakota State University, 2020. https://hdl.handle.net/10365/31936.

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Nonparametric tests are used to test hypotheses when the data at hand violate one or more of the assumptions for parametric tests procedures. The test is an ordered alternative (nondecreasing) when there is prior information about the data. It assumes that the underlying distributions are of the same type and therefore differ in location. For example, in dose-response studies, animals are assigned to k groups corresponding to k doses of an experimental drug. The effect of the drug on the animals is likely to increase or decrease with increasing doses. In this case, the ordered alternative is a

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Dunn, Rose. "Using Pre-Session Mindfulness to Improve Session Presence and Effectiveness: A Randomized-Controlled Trial." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc862760/.

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While a significant amount of research illustrates the overall positive effects of therapists' general use of mindfulness, very few studies have addressed whether therapists' use of mindfulness translates to improved psychotherapy outcomes. The present study utilized a randomized-controlled design to test whether a brief mindfulness training program and pre-session mindfulness practice could have a positive impact on therapy; in particular, we hypothesized that mindfulness training and practice would improve ratings on therapeutic presence as rated by clients and therapists and session effect

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17

Bayar, Mohamed Amine. "Randomized Clinical Trials in Oncology with Rare Diseases or Rare Biomarker-based Subtypes." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS441.

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Le design standard des essais randomisés de phase III suppose le recrutement d'un grand nombre de patients pour assurer un risque α de 0.025 unilatéral et une puissance d'au moins 80%. Ceci s'avérer difficile dans les maladies rares, ou encore si le traitement cible une population spécifique définie par un sous-type moléculaire rare. Nous avons évalué par simulation la performance d'une série d'essais randomisés. Au terme de chaque essai, s'il est associé à une amélioration significative, le traitement expérimental devient le contrôle de l'essai suivant. Les designs ont été évalués pour différ

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Byrd, Rebekah J., and Danica Hays. "Evaluating a Safe Space Training for School Counselors and Trainees Using a Randomized Control Group Design." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/880.

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School counselors need to advocate and act as an ally for all students. Safe Space, a training designed to facilitate competency for working with and serving LGBTQ youth (i.e., LGBTQ competency), has received increased attention in the field of school counseling. However, limited empirical support exists for training interventions such as Safe Space, with only one study to date examining its effectiveness for graduate psychology students (see Finkel, Storaasli, Bandele, & Schaefer, 2003). This study used a randomized pretest-posttest control group design to evaluate and examine the impact of S

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19

Bell, Melanie L., Amy L. Whitehead, and Steven A. Julious. "Guidance for using pilot studies to inform the design of intervention trials with continuous outcomes." DOVE MEDICAL PRESS LTD, 2018. http://hdl.handle.net/10150/627081.

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Background: A pilot study can be an important step in the assessment of an intervention by providing information to design the future definitive trial. Pilot studies can be used to estimate the recruitment and retention rates and population variance and to provide preliminary evidence of efficacy potential. However, estimation is poor because pilot studies are small, so sensitivity analyses for the main trial's sample size calculations should be undertaken. Methods: We demonstrate how to carry out easy-to-perform sensitivity analysis for designing trials based on pilot data using an example. F

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Orr, Serena. "The Pharmacologic Prophylaxis of Pediatric Migraine: A Systematic Review, Survey and Design of a Randomized Controlled Trial." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35109.

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Objectives: 1) To describe the state of the evidence for interventions in pediatric migraine, 2) to survey experts regarding non-inferiority margins in migraine research and 3) to design a clinical trial in this area of research. Methods: A systematic review was carried out to identify randomized, placebo-controlled trials of pharmaceutical and nutraceutical interventions used to prevent migraine in children and adolescents, using Cochrane methods. Secondly, neurologists with expertise in Headache Medicine were invited to participate in a survey regarding their opinions on non-inferiority m

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21

Hemmer, Michael Toshiro. "Nonparametric Test for the Umbrella Alternative in a Randomized Complete Block and Balanced Incomplete Block Mixed Design." Thesis, North Dakota State University, 2012. https://hdl.handle.net/10365/26696.

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Nonparametric tests have served as robust alternatives to traditional statistical tests with rigid underlying assumptions. If a researcher expects the treatment effects to follow an umbrella alternative, then the test developed in this research will be applicable in the Balanced Incomplete Block Design (Hemmer’s test). It is hypothesized that Hemmer’s test will prove to be more powerful than the Durbin test when the umbrella alternative is true. A mixed design consisting of a Balanced Incomplete Block Design and a Randomized Complete Block Design will also be considered, where two additional t

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Byrd, Rebekah J., and Danica Hays. "Evaluating a Safe Space Training for Professional School Counselors and Trainees Using a Randomized Control Group Design." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/887.

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School counselors need to advocate and act as an ally for all students. Safe Space, a training designed to facilitate competency for working with and serving LGBTQ youth (i.e., LGBTQ competency), has received increased attention in the field of school counseling. However, limited empirical support exists for training interventions such as Safe Space, with only one study to date examining its effectiveness for graduate psychology students (see Finkel, Storaasli, Bandele, & Schaefer, 2003). This study used a randomized pretest-posttest control group design to evaluate and examine the impact of S

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23

Flannery, Timothy. "Three Essays on the Incentives and Design of Survey Techniques." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/556834.

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My dissertation focuses on the design and incentives of survey techniques. As many institutions use surveys to allocate funding or determine policy, ensuring surveys provide accurate information is essential. Though incentives certainly play a role in whether survey participants report information truthfully, economists have largely overlooked the issue while statisticians tend to focus on estimators without directly modeling incentive constraints. One of the chapters models and analyzes the incentives of a commonly used survey technique, randomized response, while the other two chapters of my

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24

Cliffe, Michael John. "The randomized multiple baseline experimental design : its power and a clinical application to the cognitive modification of delusions." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/10711.

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The dissertation describes the first reported application of a small-N experimental design, the randomized baseline experimental design across subjects and behaviours. It is applied to a small scale clinical psychological experiment on the cognitive modification of delusional ideation in four people with a diagnosis of schizophrenia. The data were analysed by a form of randomization test which does not depend on the classical parametric assumptions. The randomization test based on random data permutation gave statistically significant results for the effect of the independent variable (cogniti

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25

Ndungu, Alfred Mungai. "Nonparametric Tests for the Non-Decreasing and Alternative Hypotheses for the Incomplete Block and Completely Randomized Mixed Design." Diss., North Dakota State University, 2014. https://hdl.handle.net/10365/27376.

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This research study proposes a solution to deal with missing observations which is a common problem in real world datasets. A nonparametric approach is used because of its ease of use relative to the parametric approach that beleaguer the user with firm assumptions. The study assumes data is in an Incomplete Block (IBD) and Completely Randomized (CRD) Mixed Design. The scope of this research was limited to three, four and five treatments. Mersenne - Twister (2014) simulations were used to vary the design and to estimate the test statistic powers. Two test statistics are proposed if the

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Walters, Kimberly Ann. "The Use Of Post-Intervention Data From Waitlist Controls To Improve Estimation Of Treatment Effect In Longitudinal Randomized Controlled Trials." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218445774.

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27

Park, Misook. "Design and Analysis Methods for Cluster Randomized Trials with Pair-Matching on Baseline Outcome: Reduction of Treatment Effect Variance." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/2195.

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28

Hedman, Katarina. "Pooling Data from Similar Randomized Clinical Trials Comparing Latanoprost with Timolol; Medical Results and Statistical Aspects." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3392.

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29

Guo, Yimeng. "The effect of survey design on response rates, costs, and sampling representativeness in the British Columbia Health Survey : a randomized experiment." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/47059.

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Background: Population-based survey is an essential surveillance tool applicable to various settings, including collecting information regarding community health and public living standards. In the recent decades, there have been numerous reports of decreasing response rates in population-based data collection. There is a need to redesign surveys in a way that is both more appealing to participants and maximizes response rats. Objectives: The current study explored the effects of several survey design features on participant response rates, costs, and data representativeness in a general popu

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Steiner-Boeker, Sabine. "Novel P2Y12 Receptor Antagonists - Prasugrel and Ticagrelor. Systematic Review, Indirect Comparison to Clopidogrel in Cardiovascular Disease, Design of a Randomized Controlled Trial." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20176.

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Antiplatelet therapy with clopidogrel is widely used in patients with coronary artery disease, but the recent development of the new P2Y12 receptor antagonists prasugrel and ticagrelor will increase treatment options. An overview of systematic reviews was performed to summarize available evidence on clopidogrel. Current data on prasugrel and ticagrelor were identified by a systematic review and used for an indirect treatment comparison (ITC) of the drugs against each other and versus placebo in the absence of head-to-head clinical trials. Adjusted indirect comparison according to Bucher, Bayes

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Manjang, Buba. "Investigating effectiveness of behavioural change intervention in improving mothers weaning food handling practices : design of a cluster randomized controlled trial in rural Gambia." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7471/.

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Objectives: To evaluate the effectiveness of a theory-based and culturally adapted community level behaviour change intervention to improve weaning-food preparation and handling in rural Gambia. Methods: (1) A systematic review of the literature on weaning-food hygiene interventions. (2) Mixed method formative research to identify critical control points (CCP) and motivational factors for mothers‟ behaviour on weaning-food, (3) Formulation of the weaning-food hygiene intervention including performing arts. (4) Implementation and evaluation of the intervention with a cluster randomized controll

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Mims, Pamela J. "A Technology and Systematic Instruction Based Approach to Teaching Grade Aligned ELA Skills: Results from a Year Long Randomized Control Trial." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/168.

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33

Nagalakshmi, Subramanya. "Study of FPGA implementation of entropy norm computation for IP data streams." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002477.

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34

MADASCHI, Matteo Giacomo. "Design and implementation of guidance control system for autonomous light electric vehicles." Doctoral thesis, Università degli studi di Bergamo, 2013. http://hdl.handle.net/10446/28965.

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In this work; a light AGV is presented. Light AGVs are usually designed to move small payloads and their distinctive feature is their high flexibility and re-configurability in the load handling. However; they have usually limited load weight capacity. In fact; large load weight values have a high impact on the guidance performances; even affecting the vehicle mechanical stability and strong speed limitations are usually applied. We will focus our attention to the vehicle guidance control problem and aim to design controllers that guarantees desirable specifications for a wide range of possib

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Pisinthpunth, C. "A Guideline for Environmental Games (GEG) and a randomized controlled evaluation of a game to increase environmental knowledge related to human population growth." Thesis, Coventry University, 2015. http://curve.coventry.ac.uk/open/items/ab227155-e0c9-4389-a76c-33b9f8283fcf/1.

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People often have very little knowledge about the impact of unsustainable human population growth on the environment and social well-being especially in developing countries. Therefore, an efficient method should be explored in order to educate, and if possible, to convince the members of the public to realize the environmental and social problems caused by the unsustainable population growth. Digital Game-Based Learning (DGBL) has been highlighted by some studies as an innovative tool for learning enhancement. While only a handful of studies have scientifically evaluated the impact of DGBL on

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Asmus, Josefine [Verfasser], Ivo F. [Akademischer Betreuer] [Gutachter] Sbalzarini, Christian L. [Akademischer Betreuer] Müller, and Fabian J. [Gutachter] Theis. "An Efficient Randomized Approximation Algorithm for Volume Estimation and Design Centering / Josefine Asmus ; Gutachter: Ivo F. Sbalzarini, Fabian J. Theis ; Ivo F. Sbalzarini, Christian L. Müller." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://d-nb.info/1136571426/34.

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Kotb, Ahmed. "The Impact of Telemedicine in the Rehabilitation of Patients with Heart Diseases." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30490.

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The potential that telemedicine interventions may have in effectively delivering remote specialized cardiovascular care to large numbers of patients with heart diseases has recently come under question. In the first phase of this thesis, a systematic review and meta-analysis was conducted to compare the impact of a basic form of telemedicine that is regular patient follow-up by telephone, with usual care for individuals with coronary artery disease following their discharge. In the second phase of this thesis, a network meta-analysis, using Bayesian methods for multiple treatment comparisons,

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Lacroix, Victoria. "Usability, efficacy, and perspectives of an Internet-based psycho-educational program for informal caregivers of persons with Alzheimer's disease : the contributions of an iterative user-centered design and a randomized clinical trial." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05H116/document.

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Compte tenu des risques non-négligeables liés à la prise en charge des personnes souffrant de maladie d'Alzheimer sur la santé globale et le bien-être des aidants informels, l'OMS recommande fortement la mise en place d'interventions à leur égard. Bien que les programmes en ligne représentent un outil prometteur pour ces aidants surchargés, peu de recherches ont été menées sur leur conception et leur efficacité. Le but de cette thèse de doctorat était de contribuer à la connaissance et la compréhension des processus du développement et d'évaluation de ces interventions. Pour cela, quarante-neu

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Pettersson, Anna. "Diet and Gastrointestinal Symptoms in Patients with Prostate Cancer Treated with Radiotherapy." Doctoral thesis, Uppsala universitet, Enheten för onkologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215410.

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Objective The main objective of this thesis was to explore the effects of diet on gastrointestinal symptoms in prostate cancer patients treated with local curative radiotherapy, by evaluating dietary intake prior to treatment (Study I), the psychometric properties of a new questionnaire on patient-reported gastrointestinal side effects (Study II), and the effect of a dietary intervention on acute and long-term gastrointestinal symptoms up to 2 years after radiotherapy completion (Study III-IV). Methods A total of 130 men with localized prostate cancer referred to dose-escalated radiotherapy (E

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Cerniglia, Andrew J. "The deliberate practice of procedural nursing skills: Effects of block-random sequencing on long-term retention." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1573243637786433.

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Tomaz, Pamela Kerlyane. "Altura de planta como estratégia de colheita do capim mombaça para ensilagem associada ou não a diferentes combinações de aditivos." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152489.

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Submitted by Pamela Kerlyane Tomaz null (pamelazootecnia@hotmail.com) on 2018-01-16T05:14:22Z No. of bitstreams: 1 Dissertação Pamela Kerlyane Tomaz.pdf: 1107969 bytes, checksum: 85d3dacd9e6039ed40d1831958783f96 (MD5)<br>Approved for entry into archive by Cristina Alexandra de Godoy null (cristina@adm.feis.unesp.br) on 2018-01-16T10:22:01Z (GMT) No. of bitstreams: 1 tomaz_pk_me_ilha.pdf: 1107969 bytes, checksum: 85d3dacd9e6039ed40d1831958783f96 (MD5)<br>Made available in DSpace on 2018-01-16T10:22:01Z (GMT). No. of bitstreams: 1 tomaz_pk_me_ilha.pdf: 1107969 bytes, checksum: 85d3dacd9e6039

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Soler-Font, Mercè 1991. "Prevention and management of musculoskeletal pain at work in nursing staff : Design, implementation and evaluation of a multifaceted intervention in the workplace." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/672387.

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Objectiu: Dissenyar, implementar i avaluar una intervenció multifacètica en el lloc de treball per prevenir i gestionar el dolor musculoesquelètic (DME). Mètodes: Es va dissenyar, implementar i avaluar (efectivitat, procés i cost-efectivitat) un assaig controlat aleatoritzat per clústers d'un any. La intervenció va incloure ergonomia participativa, promoció de la salut i gestió de casos. Resultats: Als 12 mesos, el grup d’intervenció va mostrar una disminució estadísticament significativa del risc de dolor d’espatlles, cervical i dorsal en comparació amb el control. No es va trobar cap efect

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Laubender, Rüdiger Paul [Verfasser]. "Estimation of a joint distribution with two normally distributed treatment responses as marginals generated in a randomized controlled trial based on the parallel-group design by using a normally distributed covariate. / Rüdiger Paul Laubender." München : Verlag Dr. Hut, 2014. http://d-nb.info/1063222001/34.

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Gao, Jinguo. "Rank Regression in Order Restricted Randomized Designs." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1374099460.

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Markiewicz, Shannon Colleen. "Nonparametric Inference Using Order Restricted Randomized Designs." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1221750077.

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Picchiottino, Mathieu. "Effets des manipulations articulaires sur les marqueurs de l'activité du système nerveux autonome The acute effects of joint manipulative techniques on markers of autonomic nervous system activity: a systematic review and meta-analysis of randomized sham-controlled trials The effect of a single spinal manipulation on cardiovascular autonomic activity and the relationship to pressure pain threshold: a randomized, cross-over, sham-controlled trial What is the effect of spinal manipulation on the pressure pain threshold in young asymptomatic subjects? A randomized placebo-controlled trial, with a cross-over design." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS103.

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L’utilisation des manipulations articulaires dans la prise en charge de certains troubles musculosquelettiques est ancienne, répandue et soutenue par la littérature scientifique. Cependant, les mécanismes d’action des différentes techniques de manipulation sont mal compris. Le potentiel effet des manipulations articulaires sur l’activité autonome est une composante fondamentale de théories relatives à leurs mécanismes d’action. Une de ces théories propose l’activation, par les manipulations articulaires, du système inhibiteur descendant de la douleur via la stimulation de la substance grise pé

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47

Harvey, Sheila. "A comparison of randomised and non-randomised study designs to evaluate health care interventions." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536804.

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48

Zheng, Wenjing. "Apprentissage ciblé et Big Data : contribution à la réconciliation de l'estimation adaptative et de l’inférence statistique." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB044/document.

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Cette thèse porte sur le développement de méthodes semi-paramétriques robustes pour l'inférence de paramètres complexes émergeant à l'interface de l'inférence causale et la biostatistique. Ses motivations sont les applications à la recherche épidémiologique et médicale à l'ère des Big Data. Nous abordons plus particulièrement deux défis statistiques pour réconcilier, dans chaque contexte, estimation adaptative et inférence statistique. Le premier défi concerne la maximisation de l'information tirée d'essais contrôlés randomisés (ECRs) grâce à la conception d'essais adaptatifs. Nous présentons

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49

Coskinas, Xanthi. "Changes to design aspects of ongoing randomised controlled trials." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29452.

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Unplanned changes to the research plan of a randomised controlled trial (RCT) may be a necessary response to unforeseen circumstances. Such changes can help ensure the value and relevance of a trial, but also have the potential to introduce a bias if performed inappropriately. This thesis addresses three broad aims. The first was to highlight the methodological implications of approaches to making various unplanned changes through a series of simulation studies. The second was to estimate the prevalence of such changes to a contemporary sample of published RCTs registered with the Australi

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Butcher, Isabella. "Design and analysis of cluster randomised trials for behavioural interventions." Thesis, Edinburgh Napier University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400594.

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