Academic literature on the topic 'RanGAP'

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Journal articles on the topic "RanGAP"

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Hutten, Saskia, Annette Flotho, Frauke Melchior та Ralph H. Kehlenbach. "The Nup358-RanGAP Complex Is Required for Efficient Importin α/β-dependent Nuclear Import". Molecular Biology of the Cell 19, № 5 (2008): 2300–2310. http://dx.doi.org/10.1091/mbc.e07-12-1279.

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In vertebrate cells, the nucleoporin Nup358/RanBP2 is a major component of the filaments that emanate from the nuclear pore complex into the cytoplasm. Nup358 forms a complex with SUMOylated RanGAP1, the GTPase activating protein for Ran. RanGAP1 plays a pivotal role in the establishment of a RanGTP gradient across the nuclear envelope and, hence, in the majority of nucleocytoplasmic transport pathways. Here, we investigate the roles of the Nup358-RanGAP1 complex and of soluble RanGAP1 in nuclear protein transport, combining in vivo and in vitro approaches. Depletion of Nup358 by RNA interfere
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HABERLAND, Jörg, and Volker GERKE. "Conserved charged residues in the leucine-rich repeat domain of the Ran GTPase activating protein are required for Ran binding and GTPase activation." Biochemical Journal 343, no. 3 (1999): 653–62. http://dx.doi.org/10.1042/bj3430653.

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GTPase activating proteins (GAPs) for Ran, a Ras-related GTPase participating in nucleocytoplasmic transport, have been identified in different species ranging from yeast to man. All RanGAPs are characterized by a conserved domain consisting of eight leucine-rich repeats (LRRs) interrupted at two positions by so-called separating regions, the latter being unique for RanGAPs within the family of LRR proteins. The cytosolic RanGAP activity is essential for the Ran GTPase cycle which in turn provides directionality in nucleocytoplasmic transport, but the structural basis for the interaction betwe
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Nishijima, Hitoshi, Jun-ichi Nakayama, Tomoko Yoshioka, et al. "Nuclear RanGAP Is Required for the Heterochromatin Assembly and Is Reciprocally Regulated by Histone H3 and Clr4 Histone Methyltransferase in Schizosaccharomyces pombe." Molecular Biology of the Cell 17, no. 6 (2006): 2524–36. http://dx.doi.org/10.1091/mbc.e05-09-0893.

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Although the Ran GTPase-activating protein RanGAP mainly functions in the cytoplasm, several lines of evidence indicate a nuclear function of RanGAP. We found that Schizosaccharomyces pombe RanGAP, SpRna1, bound the core of histone H3 (H3) and enhanced Clr4-mediated H3-lysine 9 (K9) methylation. This enhancement was not observed for methylation of the H3-tail containing K9 and was independent of SpRna1–RanGAP activity, suggesting that SpRna1 itself enhances Clr4-mediated H3-K9 methylation via H3. Although most SpRna1 is in the cytoplasm, some cofractionated with H3. Sprna1ts mutations caused d
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Seewald, Michael J., Astrid Kraemer, Marian Farkasovsky, Carolin Körner, Alfred Wittinghofer, and Ingrid R. Vetter. "Biochemical Characterization of the Ran-RanBP1-RanGAP System: Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran-RanGAP GTPase Reaction?" Molecular and Cellular Biology 23, no. 22 (2003): 8124–36. http://dx.doi.org/10.1128/mcb.23.22.8124-8136.2003.

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ABSTRACT RanBP type proteins have been reported to increase the catalytic efficiency of the RanGAP-mediated GTPase reaction on Ran. Since the structure of the Ran-RanBP1-RanGAP complex showed RanBP1 to be located away from the active site, we reinvestigated the reaction using fluorescence spectroscopy under pre-steady-state conditions. We can show that RanBP1 indeed does not influence the rate-limiting step of the reaction, which is the cleavage of GTP and/or the release of product Pi. It does, however, influence the dynamics of the Ran-RanGAP interaction, its most dramatic effect being the 20
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Faustino, Randolph S., Delphine C. Rousseau, Melanie N. Landry, Annette L. Kostenuk, and Grant N. Pierce. "Effects of mitogen-activated protein kinases on nuclear protein importThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell." Canadian Journal of Physiology and Pharmacology 84, no. 3-4 (2006): 469–75. http://dx.doi.org/10.1139/y05-131.

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ERK-2 MAP kinase activation induces inhibitory effects on nuclear protein import in vascular smooth muscle cells. The mechanism and characteristics of this effect of ERK-2 were investigated. An unusual dose-dependent effect of ERK-2 on nuclear protein import was identified. At higher concentrations (1 μg/mL) of ERK-2, nuclear protein import was stimulated, whereas lower concentrations (0.04 μg/mL) inhibited import. Intermediate concentrations exerted intermediate effects. The stimulatory and inhibitory effects at the 2 different ERK-2 concentrations were observed in both conventional, permeabi
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Askjaer, Peter, Angela Bachi, Matthias Wilm, et al. "RanGTP-Regulated Interactions of CRM1 with Nucleoporins and a Shuttling DEAD-Box Helicase." Molecular and Cellular Biology 19, no. 9 (1999): 6276–85. http://dx.doi.org/10.1128/mcb.19.9.6276.

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ABSTRACT CRM1 is an export receptor mediating rapid nuclear exit of proteins and RNAs to the cytoplasm. CRM1 export cargoes include proteins with a leucine-rich nuclear export signal (NES) that bind directly to CRM1 in a trimeric complex with RanGTP. Using a quantitative CRM1-NES cargo binding assay, significant differences in affinity for CRM1 among natural NESs are demonstrated, suggesting that the steady-state nucleocytoplasmic distribution of shuttling proteins could be determined by the relative strengths of their NESs. We also show that a trimeric CRM1-NES-RanGTP complex is disassembled
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Meier, Iris, Xiao Zhou, Jelena Brkljacić, Annkatrin Rose, Qiao Zhao, and Xianfeng Morgan Xu. "Targeting proteins to the plant nuclear envelope." Biochemical Society Transactions 38, no. 3 (2010): 733–40. http://dx.doi.org/10.1042/bst0380733.

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The nuclear envelope and the nuclear pore are important structures that both separate and selectively connect the nucleoplasm and the cytoplasm. The requirements for specific targeting of proteins to the plant nuclear envelope and nuclear pore are poorly understood. How are transmembrane-domain proteins sorted to the nuclear envelope and nuclear pore membranes? What protein–protein interactions are involved in associating other proteins to the nuclear pore? Are there plant-specific aspects to these processes? We are using the case of the nuclear pore-associated Ran-cycle component RanGAP (Ran
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Gingell, Luke F., and Janna R. McLean. "A Protamine Knockdown Mimics the Function of Sd in Drosophila melanogaster." G3: Genes|Genomes|Genetics 10, no. 6 (2020): 2111–15. http://dx.doi.org/10.1534/g3.120.401307.

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Segregation Distorter (SD) is an autosomal meiotic drive system found worldwide in natural populations of Drosophila melanogaster. This gene complex induces the preferential and nearly exclusive transmission of the SD chromosome in SD/SD+ males. This selfish propagation occurs through the interplay of the Sd locus, its enhancers and the Rsps locus during spermatid development. The key distorter locus, Sd, encodes a truncated but enzymatically active RanGAP (RanGTPase-activating protein), a key nuclear transport factor in the Ran signaling pathway. When encoded by Sd, RanGAP is mislocalized to
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Seewald, Michael J., Carolin Körner, Alfred Wittinghofer, and Ingrid R. Vetter. "RanGAP mediates GTP hydrolysis without an arginine finger." Nature 415, no. 6872 (2002): 662–66. http://dx.doi.org/10.1038/415662a.

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Kusano, A., C. Staber, and B. Ganetzky. "Segregation distortion induced by wild-type RanGAP in Drosophila." Proceedings of the National Academy of Sciences 99, no. 10 (2002): 6866–70. http://dx.doi.org/10.1073/pnas.102165099.

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Dissertations / Theses on the topic "RanGAP"

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Seewald, Michael J. "Kristallographische und biochemische Untersuchungen zum Proteinkomplex Ran, RanBP1, RanGAP." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966394577.

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Rodrigo-Peiris, Thushani. "Unraveling the Functions of Plant Ran GTPase-Activating Protein (RanGAP) by T-DNA Mutant Analysis and Investigation of Molecular Interactions of Tandem Zinc Finger 1 (TZF1) in Arabidopsis thaliana." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343796551.

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Jeong, Sun Yong. "Functional investigation of arabidopsis long coiled-coil proteins and subcellular localization of plant rangap1." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1086119855.

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Anna, Newman-Griffis Hare. "Plant nuclear envelope-associated proteins function in development and symbiosis." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1542733901078983.

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Rosas, Salvans Miquel 1987. "Understanding RanGTP dependent microtubule assembly : Idenification of DnaJB6 as a RanGTP regulated factor involved in microtubule organization during mitosis." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/664169.

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Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the spindle, all these MTs are organized by various classes of motor proteins into two interdigitating antiparallel arrays with their minus ends focused at the spindle poles. This focusing activity is provided by the minus-end directed motor proteins Dynein-Dynactin and HSET. Spindle assembly can occur in the absence of centrosomes indicating that the RanGTP and augmin dependent pa
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Scrofani, Jacopo 1984. "Mechanism of RanGTP dependent microtubule assembly during mitosis." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/289621.

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During mitosis, spindle assembly involves different sources of microtubules including centrosomes and chromosomes. While the role of centrosomes has been extensively studied, we still do not fully understand how chromosomes trigger microtubule assembly thereby contributing to the formation of the mitotic spindle. The chromosomal pathway is largely determined by a RanGTP gradient centered on the chromosomes that induces the local activation of spindle assembly factors. To get a better understanding on the RanGTP-dependent microtubule assembly during mitosis we aimed at: i) Identifying new Ran
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Wagenhofer, Markus. "Block numerical ranges." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=98404972X.

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Moore, Maximo A. "Ranger Air Load Planner." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2000. http://handle.dtic.mil/100.2/ADA380251.

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鄭金木 and Kam-muk Cheng. "Plotting generalized numerical ranges." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31220514.

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Cheng, Kam-muk. "Plotting generalized numerical ranges /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20792736.

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Books on the topic "RanGAP"

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Thailand. Kotmāi læ rabīapkān kīeokap kānpo̜ngkan læ rangap ʻakkhīphai. Kō̜ng Pō̜ngkan Fāi Phonlarư̄an, Krom Kānpokkhrō̜ng, Krasūang Mahātthai, 1988.

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Narvekara, Sriranga. Rangata rangalo mi. Sagara Sriranga Narvekara va Abhinaya Sriranga Naarvekara, 2009.

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Alibegova, Bikekhanum. Zulun rangar. Dagestanskoe knizhnoe izd-vo, 1994.

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Sēdara, Nimal. Ranga maḍala. Dayāvamśa Jayakoḍi saha Sahōdarayō, 2013.

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Sindh (Pakistan). Department of Culture and Tourism, ed. Sabhu ranga. S̲aqāfata Khāto, Ḥukūmat-i Sindhu, 2012.

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Mule, Jnanesvara. Nokarasaice ranga. Srividya Prakasana, 2009.

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Gulhāʼe rangā rang. Maqṣūd Iláhī Shaik̲h̲, 2003.

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Redī rangay obahʼ. T̤āhir Buk Sainṭar, 2013.

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Nayyar, F. R. Ranga rang mehdi. Nawab Sons, 2001.

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An Seomra ranga. Clóchomhar Tta, 1989.

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Book chapters on the topic "RanGAP"

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Ponstingl, Herwig, and F. Ralf Bischoff. "RCC1-Ran-RanGAP Signal for Initiation of Mitosis." In Chromosome Segregation and Aneuploidy. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-84938-1_14.

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Peng, Kun, and Feng Bao. "Batch Range Proof for Practical Small Ranges." In Progress in Cryptology – AFRICACRYPT 2010. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12678-9_8.

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Thomas, Gerald W. "The Western Range and the Livestock Industry It Supports." In Range Research and Range Problems. Crop Science Society of America, 2015. http://dx.doi.org/10.2135/cssaspecpub3.c1.

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Raleigh, R. J. "Range Forage and Animal Nutrition." In Range Research and Range Problems. Crop Science Society of America, 2015. http://dx.doi.org/10.2135/cssaspecpub3.c2.

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Theurer, C. Brent. "Nutrient and Botanical Composition of the Diet of Cattle Grazing Native Range." In Range Research and Range Problems. Crop Science Society of America, 2015. http://dx.doi.org/10.2135/cssaspecpub3.c3.

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Binns, Wayne. "Effects of Poisonous Plants on the Range Livestock Industry." In Range Research and Range Problems. Crop Science Society of America, 2015. http://dx.doi.org/10.2135/cssaspecpub3.c4.

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Morton, H. L. "Weed and Brush Control for Range Improvement." In Range Research and Range Problems. Crop Science Society of America, 2015. http://dx.doi.org/10.2135/cssaspecpub3.c5.

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Herbei, Carlton H. "Some Developments Related to Seeding Western Rangelands." In Range Research and Range Problems. Crop Science Society of America, 2015. http://dx.doi.org/10.2135/cssaspecpub3.c6.

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Rogler, George A., and Russell J. Lorenz. "Fertilization for Range Improvement." In Range Research and Range Problems. Crop Science Society of America, 2015. http://dx.doi.org/10.2135/cssaspecpub3.c7.

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Keller, Wesley. "Summary and Prospects." In Range Research and Range Problems. Crop Science Society of America, 2015. http://dx.doi.org/10.2135/cssaspecpub3.c8.

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Conference papers on the topic "RanGAP"

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Chatterjee, Monish R., and Ali A. Mohamed. "Mitigation of image intensity distortion using chaos-modulated image propagation through gamma-gamma atmospheric turbulence." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2306482.

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Kulikov, Victor A., Mikhail Vorontsov, and Zhijun Yang. "Accounting for optical refractivity and turbulence effects in optical wave propagation over long distances." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2304472.

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Spencer, Mark F., Douglas E. Thornton, Glen P. Perram, and Christopher A. Rice. "Efficiency measurements for a digital-holography system." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2304689.

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Spencer, Mark F., Casey J. Pellizzari, and Charles A. Bouman. "Optically coherent image reconstruction in the presence of phase errors using advanced-prior models." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2304692.

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Spencer, Mark F., and Douglas E. Thornton. "Signal-to-noise models for digital-holographic detection." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2304695.

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Karr, Brian A., George A. Downey, and Nathan A. Harris. "Electro-optical tracking considerations III." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2304796.

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Hardie, Russell, Michael Rucci, Barry Karch, Alex Dapore, and Doug Droege. "Super-resolution in the presence of atmospheric optical turbulence." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2303657.

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Murguia, James E., and Jonathan M. Mooney. "Variable aperture lucky look approach to imaging through deep turbulence." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2303857.

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Gueler, Richard, Craig Olson, and Andrew Sparks. "Estimating uncertainty in limiting resolution of full motion video." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2304052.

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Peled, Gal, Nir Karasikov, Roman Yasinov, et al. "Precision motion enables unique optical zoom and staring capabilities of a miniature payload (Conference Presentation)." In Long-Range Imaging III, edited by Eric J. Kelmelis. SPIE, 2018. http://dx.doi.org/10.1117/12.2311454.

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Reports on the topic "RanGAP"

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Irwin, Jeffrey D., and Heather L. McDonald. Range Riders and Game Wardens: A Brief History of Fort Bragg's Forest Ranger Program. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada463598.

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McDonough, M. R., and P. S. Simony. Geology of the northern Selwyn Range, western Main Ranges, Rocky Mountains, British Columbia: Preliminary Report. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1986. http://dx.doi.org/10.4095/120433.

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Meade, Roger. Ranger. Office of Scientific and Technical Information (OSTI), 2021. http://dx.doi.org/10.2172/1821340.

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Hernandez, J., R. Smith, V. Petty, and J. Lock. Development of Range Design Elements and Quality Control/Quality Assurance Guidance to Reduce Maintenance Requirements on Training Ranges. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada460751.

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Svendsen, Niels G., Prasanta K. Kalita, and Dick L. Gebhart. Evaluation of Soil Loss and Erosion Control Measures on Ranges and Range Structures at Installations in Temperate Climates. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada467835.

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Chapman, Elaine G., James C. Barnard, Frederick C. Rutz, Mikhail S. Pekour, Jeremy P. Rishel, and William J. Shaw. Dust Plume Modeling from Ranges and Maneuver Areas on Fort Bliss and the White Sands Missile Range: Final Report. Office of Scientific and Technical Information (OSTI), 2009. http://dx.doi.org/10.2172/957366.

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Kistner-Thomas, Erica. Potential Geographical Range & Abundance of the Invasive Brown Marmorted Stink Bug under Climate Change Scenarios. USDA Midwest Climate Hub, 2019. http://dx.doi.org/10.32747/2018.6947063.ch.

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Climate change is predicted to exacerbate agricultural losses from crop pests and pathogens by 1) expanding their geographic ranges, 2) reducing winter die-offs, and 3) increasing the number of generations produced per year. For example, numerous crop pests and pathogens have expanded their range northward since the 1960s due, in part, to warming annual temperatures.
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Bourgeois, Brian S. Using Range and Range Rate for Relative Navigation. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada472033.

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Zhao, Haoran, William Delp, Wanyu Chan, Iain Walker, and Brett Singer. Measured Performance of Over the Range Microwave Range Hoods. Office of Scientific and Technical Information (OSTI), 2020. http://dx.doi.org/10.2172/1658356.

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Drummond, J. Safety Precautions for Test Ranges. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada476729.

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