Academic literature on the topic 'Rapid mixing device'

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Journal articles on the topic "Rapid mixing device"

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Kahn, James, Robert N. Dutnall, Kimberly Matulef, and Leigh A. Plesniak. "Measurement of kon without a rapid-mixing device." Biochemistry and Molecular Biology Education 38, no. 4 (2010): 238–41. http://dx.doi.org/10.1002/bmb.20369.

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Yasui, Takao, Yusuke Omoto, Keiko Osato, et al. "Microfluidic baker's transformation device for three-dimensional rapid mixing." Lab on a Chip 11, no. 19 (2011): 3356. http://dx.doi.org/10.1039/c1lc20342h.

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Beck, Christian, Sameer V. Dalvi, and Rajesh N. Dave. "Controlled liquid antisolvent precipitation using a rapid mixing device." Chemical Engineering Science 65, no. 21 (2010): 5669–75. http://dx.doi.org/10.1016/j.ces.2010.04.001.

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TAKAHASHI, Satoshi. "Protein, Solution Mixing and Microfabrication- Observation of Protein Folding Dynamics by Rapid Mixing Device -." Review of Laser Engineering 37, no. 7 (2009): 515–20. http://dx.doi.org/10.2184/lsj.37.515.

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Dingfelder, Fabian, Bengt Wunderlich, Stephan Benke, et al. "Rapid Microfluidic Double-Jump Mixing Device for Single-Molecule Spectroscopy." Journal of the American Chemical Society 139, no. 17 (2017): 6062–65. http://dx.doi.org/10.1021/jacs.7b02357.

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Hsu, Hsiang Chen, Hsi Chien Liu, and Cheng Jiun Han. "Fabrication of Microfluidic Rapid Micromixer." Key Engineering Materials 467-469 (February 2011): 2013–17. http://dx.doi.org/10.4028/www.scientific.net/kem.467-469.2013.

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A microfluidic multi-cylindric rapid micromixer is fabricated in the present paper. The key features in the presented MEMS-based microchannel design are (1) micro pump (2) Y-junction type channel (3) cylindric obstacle (4) notch with the edge of sharp teeth. Two different fluids (DI water and red ink) were pumped and injected into Y-type channel, and the fluids were broken-up by a cylindric obstacle in the center of tapered microchannel. The chaotic convection occurs in the mixing channel behind the cylindric obstacle. The mixing index is defined to qualify the mixing efficiency, which demonst
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Shanko, Eriola-Sophia, Yoeri van de Burgt, Patrick D. Anderson, and Jaap M. J. den Toonder. "Microfluidic Magnetic Mixing at Low Reynolds Numbers and in Stagnant Fluids." Micromachines 10, no. 11 (2019): 731. http://dx.doi.org/10.3390/mi10110731.

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Microfluidic mixing becomes a necessity when thorough sample homogenization is required in small volumes of fluid, such as in lab-on-a-chip devices. For example, efficient mixing is extraordinarily challenging in capillary-filling microfluidic devices and in microchambers with stagnant fluids. To address this issue, specifically designed geometrical features can enhance the effect of diffusion and provide efficient mixing by inducing chaotic fluid flow. This scheme is known as “passive” mixing. In addition, when rapid and global mixing is essential, “active” mixing can be applied by exploiting
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Besnea, Daniel, Alina Spanu, Iuliana Marlena Prodea, Gheorghita Tomescu, and Iolanda Constanta Panait. "Constructive Optimisation of the Propeller Type Mixing Devices Using the Virtual and Rapid Prototyping." Revista de Chimie 68, no. 3 (2017): 453–58. http://dx.doi.org/10.37358/rc.17.3.5477.

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The paper points out the advantages of rapid prototyping for improving the performances/constructive optimization of mixing devices used in process industries, here exemplified to propeller types ones. The multidisciplinary optimization of the propeller profile affords its design using parametric CAD methods. Starting from the mathematical curve equations proposed for the blade profile, it was determined its three-dimensional virtual model. The challenge has been focused on the variation of propeller pitch and external diameter. Three dimensional ranges were manufactured using the additive man
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Zhang, Ke, Ruifeng Liu, Tom Irving, and David S. Auld. "A versatile rapid-mixing and flow device for X-ray absorption spectroscopy." Journal of Synchrotron Radiation 11, no. 2 (2004): 204–8. http://dx.doi.org/10.1107/s0909049503028474.

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Zinck, Nicholas, Ann-Kathrin Stark, Derek J. Wilson, and Michal Sharon. "An Improved Rapid Mixing Device for Time-Resolved Electrospray Mass Spectrometry Measurements." ChemistryOpen 3, no. 3 (2014): 109–14. http://dx.doi.org/10.1002/open.201402002.

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Dissertations / Theses on the topic "Rapid mixing device"

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Li, Wei. "Elaboration par un procédé de précipitation de nanoparticules aux propriétés contrôlées : application à la magnétite." Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL024N/document.

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Ce travail concerne le développement, la mise au point et la modélisation d’un procédé de précipitation de nanoparticules. Le précipité « modèle » étudié est la magnétite (Fe3O4). La méthode chimique de Massart est choisie pour fabriquer les nanoparticules de magnétite, car elle est déjà bien étudiée. Un procédé de précipitation est conçu en réacteur semi-fermé et à recirculation du fluide de la cuve, permettant ainsi de réaliser un mélange intensif des fluides réactifs par des mélangeurs rapides (un tube en T et deux mélangeurs Hartridge-Roughton de tailles différentes). Différents paramètres
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Book chapters on the topic "Rapid mixing device"

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Buranda, Tione, and Larry A. Sklar. "Flow Cytometry, Beads, and Microchannels." In Flow Cytometry for Biotechnology. Oxford University Press, 2005. http://dx.doi.org/10.1093/oso/9780195183146.003.0010.

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Microfluidic devices generally consume microliter to submicroliter volumes of sample and are thus well suited for use when the required reagents are scarce or expensive. Because microfluidic devices operate in a regime in which small Reynolds numbers govern the delivery of fluid samples, reagent mixing and subsequent reactivity has been a severe limiting factor in their applicability. The inclusion of packed beads in the microfluidic device repertoire has several advantages: molecular assemblies for the assay are created outside the channel on beads and characterized with flow cytometry, uniform populations of beads may be assured through rapid cytometric sorting, beads present a larger surface area for the display of receptors than flat surfaces, rapid mixing in the microcolumn is achieved because the distance that must be covered by diffusion is limited to the (≤1-μm) interstitial space between the closely packed receptorbearing beads, and analytes are captured in a flow-through format and, as such, each bead can act as a local concentrator of analytes. Progress in the combined use of beads and microfluidic devices has been limited by the ability to pack beads at specific sections of microfluidic devices. A subsequent challenge associated with the packed microcolumns of beads is the substantial pressure drop that affects the fluid flow velocity. However, some of these challenges have been overcome in the design of simple model systems that have potential applications in DNA analysis, chromatography, and immunoassays. It is the intent of this chapter to examine the recent emergence of small-volume heterogeneous immunoassays, using beads trapped in microchannels, while excluding other closely related applications such as capillary electrophoresis and flow injection–based approaches. Of necessity, the authors’ interests and availability of information pertinent to the specific discussions presented below impose additional restrictions. To date, there are only a handful of applications that combine packed beads and microfluidic devices, and even fewer that make the overt connection between flow cytometry–based assays and beads. Harrison and coworkers have provided one of the earliest conceptual demonstrations of the capability to incorporate packed beads in microfluidic devices for analytical purposes.
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Gore, Michael G., and Stephen P. Bottomley. "Stopped-flow fluorescence spectroscopy." In Spectrophotometry and Spectrofluorimetry. Oxford University Press, 2000. http://dx.doi.org/10.1093/oso/9780199638130.003.0013.

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Biochemical reactions, such as substrate or coenzyme binding to enzymes are usually completed in no more than 50-100 ms and thus require rapid reaction techniques such as stopped-flow instrumentation for their study. Fortunately, many such reactions can be followed by changes in the absorption properties of the substrate, product or coenzyme, and examples of these have been described in Chapters 1, 7 and 8. An alternative possibility is that during the reaction there is a change in the fluorescence properties of the substrate, coenzyme or the protein itself. Some reactions, particularly those involving the oxidation/ reduction of coenzymes, involve both changes in absorption and changes in fluorescence emission intensity. In many cases, the fluorescence properties of the ligand or protein itself may change when a complex is formed, even in the absence of a full catalytic reaction occurring, e.g. the protein fluorescence emission of most pyridine or flavin nucleotide-dependent dehydrogenases is quenched when NAD(P)H or FADH (respectively) binds to them, due to resonance energy transfer from the aromatic amino acids of the protein to the coenzyme. Conversely, the fluorescence emission from the reduced-coenzymes is usually enhanced on formation of the complex with these enzymes (1-3). The principles behind both fluorescence and stopped-flow techniques have been described in preceding chapters (2 and 8, respectively) and therefore readers should familiarize themselves with these chapters for some of the background information. In this chapter, we discuss the use of stopped-flow fluorescence spectroscopy and its application to a number of biochemical problems. A typical stopped-flow system is assembled from modular components of a conventional spectrophotometer/fluorimeter, a device permitting rapid mixing of the components of a reaction and a data recording system with a fast response. Commercially available instruments offer facilities for the observation of changes in absorption and/or fluorescence emission after rapid mixing of the reagents. These measurements can often be made simultaneously due to the different optical requirements of the two spectroscopic techniques. Figure 1 gives a generalized diagram of the geometry of a stopped-flow system able to simultaneously measure changes in absorption and fluorescence intensity of a reaction.
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Conference papers on the topic "Rapid mixing device"

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Wang, Lilin, and Jing-Tang Yang. "Rapid Mixing in an Overlapping Crisscross Micromixer." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-81145.

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We have developed a novel PDMS-based microfluidic mixer that incorporates an overlapping crisscross entrance with patterned microchannels and that acts as a high-performance micromixer. Such an entrance design generates significant flow tumbling and promotes axial advection between mixing fluids. A systematic numerical analysis reveals the overall mixing trends and the bulk flow structure. The downstream mixing performance is greatly enhanced as a result of the design of the entrance, at which there is vertical advection between mixing fluids, and four split flow zones generated by a staggered
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Xia, Zheng, Lou Cattafesta, Mark Sheplak, Renwei Mei, and Z. Hugh Fan. "Fluid Mixing in Channels With Microridges." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43052.

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Microflows in complex channels with uneven surface often display unusual flow behavior compared to their macroscale counterparts. Channels with micro ridges are created in a plastic device using photolithography and molding. Recirculation is reported in the flow in these ridged channels [1]. We use recirculation to enhance fluid mixing and the utility is demonstrated by homogenizing fluorescein and water in the microchannels. In addition, deconvolution microscopy is developed to visualize the fluid flow in the ridged channel. Flow twisting, as expected, results in enhanced fluid mixing; the fl
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Lu, Hua, Xiaoyu Ding, Dacan Yang, Peng Qu, and Yi Tao. "A Labview Based Motion Control System for the Development of a Fluorescence Ultra-Fast Continuous Flow Rapid Mixing Device." In 2010 Symposium on Photonics and Optoelectronics (SOPO 2010). IEEE, 2010. http://dx.doi.org/10.1109/sopo.2010.5504079.

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Deinert, B., and J. Hourmouziadis. "Enhancement of Mixing Effectiveness in Skewed Streams." In ASME Turbo Expo 2004: Power for Land, Sea, and Air. ASMEDC, 2004. http://dx.doi.org/10.1115/gt2004-53074.

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Forced mixers are used to improve the performance (thrust and SFC) and to reduce jet-mixing noise of turbofan engines. Therefore every effort has been made to enhance the mixing from forced exhaust mixers. A lobed type of forced mixer induces rapid mixing by enhancing the streamwise vorticity and increasing the interfacial area. Lobed mixer effectiveness can be further enhanced through the introduction of smaller scale mixing devices. For the design of these mixing devices it is important to keep in mind, that the devices have to produce smaller scale vorticity, but with an acceptable pressure
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Garfield, M. Robert, and Alex Dupont. "Augmented Reality Aided Medical Device Design." In 2019 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/dmd2019-3215.

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Blurring the line between the physical and digital environment, augmented reality (AR) is the next frontier for medical device design. It is particularly useful as a means for rapid concept visualization and iterative refinement. By selectively mixing AR and physical prototypes, designers can conduct haptic evaluation alongside visual assessment. The integration of AR and traditional tools during development continues the practice of advancing design methods in parallel with technology. This paper explains the design of a mobile medical device/workstation using an AR aided medical device desig
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Bergman, Richard, Alexander Efremov, and Pierre Woehl. "Numerical Mixing Analysis of a Vaned Circular Micromixer." In ASME 4th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2006. http://dx.doi.org/10.1115/icnmm2006-96016.

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Mixing of fluids is a common and often critical step in microfluidic systems. In typical large scale processes turbulence greatly speeds the mixing process. At the mini and micro-scales, however, the flow is laminar and the benefits of turbulent mixing are not present. Mixing at the mini- and micro-scales tends to become a more highly engineered process of bringing fluids together in predictable ways to achieve a predetermined and acceptable level of mixing. This paper summarizes a numerical analysis of the mixing performance of a vaned circular micromixer. A newly developed mixing metric suit
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Cai, Qingjun, Chialun Tsai, Jeff DeNatale, and Chung-Lung Chen. "Fluid Mixing in Micro Scale Channel Patterned Hydrophobic/Hydrophilic Surface." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-13739.

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Micro scale fluid control or mixing is critical for chemistry and life sciences. Successful performance of on-chip biochemical analysis processes, such as DNA hybridization and PCR amplification, highly depend on rapid mixing of multiple fluid species. In this paper, a set of initial designs is developed for flow mixing. In micro channels with 100 and 200μm width, alternating regions of hydrophobic/hydrophilic surface are created on silicon surfaces by photolithography and dry etch techniques. Experimental results show that in the micro channels with 20mm length, effective mixing is observed o
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Heo, Hyeung Seok, and Yong Kweon Suh. "Study on the Mixing Performance Inside a Micromixer by Using Rapid-Prototyping Technology and Micro-LIF System." In ASME 2004 2nd International Conference on Microchannels and Minichannels. ASMEDC, 2004. http://dx.doi.org/10.1115/icmm2004-2415.

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In this study a newly fabricated micromixer is proposed. This design comprises periodically arranged simple blocks. In this configuration, the stirring is greatly enhanced at a certain parameter set. This device is fabricated by rapid prototyping technology, stereolithography method, so that we can reduce the R&D time and cost. To characterize the flow field and the stirring effect both the numerical and experimental methods were employed. To obtain the material deformation, three-dimensional numerical computation to the Navier Stokes equations are performed by using a commercial code, FLU
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Chen, Z., J. M. MacInnes, B. O’Sullivan, and P. Zhou. "Design and Performance of a Folding Flow Network Micromixer." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68914.

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Effective and rapid mixing of liquid solutions is a fundamental requirement in the design of many types of micro-flow systems. Constraints of both rapid and complete mixing place considerable demands on mixer performance. Especially for those liquids with high viscosities and low diffusivities, mixing is particularly important, however, difficult, for processes associated with chemical reaction. A design of a mixer using a network of microchannels to split and recombine the flow repeatedly is introduced in the paper. Such a mixer has been incorporated by the authors into a device for carrying
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Nalbach, Joseph R., Dave Jao, Douglas G. Petro, et al. "Fabrication of Tunable Silk Materials Through Microfluidic Mixers." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-65623.

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A common method to precisely control the material properties is to evenly distribute functional nanomaterials within the substrate. For example, it is possible to mix a silk solution and nanomaterials together to form one tuned silk sample. However, the nanomaterials are likely to aggregate in the traditional manual mixing processes. Here we report a pilot study of utilizing specific microfluidic mixing designs to achieve a uniform nanomaterial distribution with minimal aggregation. Mixing patterns are created based on classic designs and then validated by experimental results. The devices are
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