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Journal articles on the topic 'Rare fibroblastic neoplasm'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Córdoba-Fernández, Antonio, José María Juárez-Jiménez, José Mazuecos-Blanca, and Matilde Illanes-Moreno. "A Report of a Rare Case of Myxoinflammatory Fibroblastic Sarcoma." Journal of the American Podiatric Medical Association 100, no. 6 (2010): 497–501. http://dx.doi.org/10.7547/1000497.

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Myxoinflammatory fibroblastic sarcoma of the soft tissues is a rare low-grade tumor of uncertain origin that most often occurs on the extremities of adults. The tumor predominantly involves the subcutaneous tissues of the hands and feet. Despite being a rare neoplasm, owing to its varied histologic appearance, myxoinflammatory fibroblastic sarcoma should be differentiated from various benign and malignant soft-tissue lesions. Myxoinflammatory fibroblastic sarcoma has been well described in pathology journals but not in the surgical literature. We report a case of myxoinflammatory fibroblastic

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2

Lee, Eun Sun. "Malignant Solitary Fibrous Tumor of Ileum with Intussusception." Korean Journal of Abdominal Radiology 5, no. 1 (2021): 77–80. http://dx.doi.org/10.52668/kjar.2021.00038.

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Solitary fibrous tumor (SFT) is rare mesenchymal neoplasm of fibroblastic or myofibroblastic origin. Especially, extrapleural SFT is known to be extremely rare. Here, we report a case of malignant SFT of ileum, resulting in small bowel intussusception in a 74-year-old female patient.

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Rynda, Artemiy, Viktor Olyushin, Yuliya Zabrodskaya, and Dmitriy Rostovtsev. "METASTASIS PRIMARY MYXOFIBROSARCOMA FROM THE HEART OF IN BRAIN. CASE REPORT." Problems in oncology 65, no. 3 (2019): 467–74. http://dx.doi.org/10.37469/0507-3758-2019-65-3-467-474.

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Background: myxofibrosarcoma is rare a fibroblastic neoplasm with myxoid matrix. Objective: to show rare case of heart myxofibrosarcoma with brain metastasis. Materials and methods: 52-year-old women, clinical manifestations were headaches, left hemiparesis, intellection-amnestic disorder. Results: radical operation with intraoperative photodynamic therapy has been executed.

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Berres-Wehrle, Frauke, Khaled Mukkadam, Daniel Baumhoer, and Michael M. Bornstein. "Peripheres odontogenes Fibrom im Oberkiefer bei einem 26-jährigen Patienten." SWISS DENTAL JOURNAL SSO – Science and Clinical Topics 131, no. 11 (2021): 924–25. http://dx.doi.org/10.61872/sdj-2021-11-04.

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Peripheral odontogenic fibroma (POF) is a rare and benign neoplasm consisting of a mature fibroblastic spindle cell proliferation and variable inclusions of odontogenic epithelium. It can occur in both the maxilla and mandible.

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Mohamedali, Rasheeda, Nilay Nishith, Rahul Raj, et al. "Unveiling Rare Breast Neoplasms: Diagnostic Challenges and Insights." Discoveries 12, no. 4 (2024): e200. https://doi.org/10.15190/d.2024.19.

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Breast neoplasm encompasses a diversified range of different diseases characterized by unique biological and pathological features, clinical presentation, response to treatments, clinical behavior, and outcome. The histological variability has profound prognostic implications, thus playing a pivotal role in diagnosing breast neoplasm. Special histologies can occur rarely, and most information on outcomes and treatments is mainly derived from small series and case reports. Thus, reporting such unusual occurrences is of utmost importance. This is a retrospective study of four years in which 11 c

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6

Hallin, Magnus, Yurina Miki, Andrew J. Hayes, Robin L. Jones, Cyril Fisher, and Khin Thway. "Acral myxoinflammatory fibroblastic sarcoma with hybrid features of hemosiderotic fibrolipomatous tumor occurring 10 years after renal transplantation." Rare Tumors 10 (January 1, 2018): 203636131878262. http://dx.doi.org/10.1177/2036361318782626.

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Myxoinflammatory fibroblastic sarcoma is a rare malignant soft tissue neoplasm that typically arises on the distal extremities of adults. It usually behaves in a low-grade manner and its characteristic histology is of a lobulated proliferation of moderately atypical spindled to epithelioid cells, vacuolated cells, and enlarged or bizarre cells with prominent nucleoli, dispersed within myxoid stroma containing a mixed inflammatory cell infiltrate. The etiology of myxoinflammatory fibroblastic sarcoma remains unknown with no definite causal factors identified. We describe a case of myxoinflammat

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7

Jain, Ekta, Lata Kini, Rita Alaggio, and Sarangarajan Ranganathan. "Myxoinflammatory Fibroblastic Sarcoma of Eyeball in an Infant: A Rare Presentation." International Journal of Surgical Pathology 28, no. 3 (2019): 306–9. http://dx.doi.org/10.1177/1066896919879497.

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare soft tissue neoplasm most commonly occurring in the distal extremities of adult patients. It is a low-grade neoplasm with high rate of local recurrence but low rate of metastasis. We describe a case of MIFS of eyeball in an infant. An enucleation surgery was performed, and on the basis of histopathological and immunohistochemical evaluation, a diagnosis of MIFS was rendered. Till date more than 400 cases of MIFS have been reported with only a single case report of MIFS in an adult in iris. To the best of our knowledge, ours is the first ca

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8

Ieremia, Eleni, and Khin Thway. "Myxoinflammatory Fibroblastic Sarcoma: Morphologic and Genetic Updates." Archives of Pathology & Laboratory Medicine 138, no. 10 (2014): 1406–11. http://dx.doi.org/10.5858/arpa.2013-0549-rs.

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a malignant mesenchymal neoplasm most frequently arising in the distal extremities of adults, which usually behaves in a low-grade manner but is capable of metastasizing to local and distant sites, rarely leading to death. It is a rare tumor whose unusual morphology can lead to erroneous histologic diagnosis, either as a nonneoplastic (infectious or inflammatory) process or as a variety of neoplastic diseases. While its exact origin is uncertain, ultrastructural studies have shown at least some of the constituent cells to be modified fibroblasts.

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9

Shetty, Rohan, Shubha Bhat, Rajesh Ballal, Pramod Makannavar, and Anil Kumar K. N. "AGGRESSIVE MESENTRIC FIBROMATOSIS: A RARE CASE REPORT AND REVIEW OF LITERATURE." Journal of Health and Allied Sciences NU 03, no. 01 (2013): 79–82. http://dx.doi.org/10.1055/s-0040-1703641.

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AbstractMesentric fibromatosis is a proliferative fibroblastic neoplasm of the small intestinal mesentery with varied clinical presentation. Giant mesentric fibromatosis is uncommon and its rarity poses a diagnostic and therapeutic challenge. This paper presents a recurrent aggressive fibromatosis in a 38 year old male patient, who had initially undergone a laparotomy outside for mass abdomen but only pus was evacuated and definitive diagnosis was not made.

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10

Kamble, Pradnya, Jayashree Chaudhari, and Manisha Khare. "Superficial CD34 Positive Fibroblastic Tumor: A rare mesenchymal tumor of borderline malignant potential." Journal of Pathology of Nepal 14, no. 2 (2024): 2232–35. https://doi.org/10.3126/jpn.v14i2.64485.

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Superficial CD34 positive fibroblastic tumor is a rare soft tissue tumor first brought to light by Jodi M Carter in 2014. Several cases have been reported since, and they have been newly included in the recent WHO classification under the fibroblastic and myofibroblastic tumors category. It is a mesenchymal neoplasm of borderline malignant potential predominantly found in middle-aged adults with a median age of 37 years and most commonly located in the lower extremities. It is a spindle cell tumor with pleomorphic epithelioid cells, low mitotic activity, and strong diffuse positivity for CD34

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11

Güzeldir, Osman Tuğrul. "Myxoinflammatory fibroblastic sarcoma of the submandibular gland." Praxis of Otorhinolaryngology 10, no. 1 (2022): 40–43. http://dx.doi.org/10.5606/kbbu.2022.42104.

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade soft tissue tumor, it usually affecting the distal extremities. Upon conducting a literature review, we could not find a case of MIFS in the submandibular gland. In this study, we described a 44-year-old female patient who presented to our clinic with a complaint of swelling under the left side of her submandibular region that had persisted for eight months. Due to an initial diagnosis of submandibular gland neoplasm, the gland was totally excised. The pathological examination report indicated MIFS, and therefore, the patient was

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12

Gedam, Bapuji S., Quraysh S. Sadriwala, and Nikita J. Kulkarni. "Nodular fasciitis: a rare case report type of article." International Surgery Journal 4, no. 11 (2017): 3770. http://dx.doi.org/10.18203/2349-2902.isj20174904.

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Nodular fasciitis is defined as a benign and reactive fibroblastic growth extending from the superficial fascia into the subcutaneous tissue or muscle. It is a rare benign neoplasm most commonly afflicting the soft tissues of upper extremity followed by trunk, head, and neck. It accounts for 0.025% of all pathologic diagnosis. We report a case of a swelling over the right scapula which on cytology examination was diagnosed as a benign spindle cell lesion. It was subsequently confirmed to be an intramuscular nodular fasciitis on histopathological examination.

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13

Koechlin, Luca, Andreas Zettl, Dieter Koeberle, Markus von Flüe, and Martin Bolli. "Metastatic Inflammatory Myofibroblastic Tumor of the Spleen: A Case Report and Review of the Literature." Case Reports in Surgery 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/8593242.

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Introduction. Inflammatory myofibroblastic tumors (IMT) of the spleen are rare neoplasms and only little is known about the origin and behavior of these tumors. Here we report the case of a 37-year-old woman with an atypical spindle cell neoplasm showing features strongly suggesting an IMT of the spleen with hepatic metastasis. Methods. A 37-year-old patient had been complaining about pain in the left upper abdomen for the last two months. A CT scan revealed a tumor mass in her spleen and liver. After complete staging, a splenectomy and atypical liver resection of segments VII and VIII were pe

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14

Holubar, Stefan, Amit J. Dwivedi, and James O'Connor. "Giant Mesenteric Fibromatosis Presenting as Small Bowel Obstruction." American Surgeon 72, no. 5 (2006): 427–29. http://dx.doi.org/10.1177/000313480607200512.

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Mesenteric fibromatosis is a proliferative fibroblastic neoplasia of the small intestine mesentery that may occur as a unique or multiple formation. Mesenteric fibromatosis is a rare, locally aggressive neoplasm and may present with abdominal discomfort, abdominal pain, weight loss, or symptoms of ureteral obstruction, mesenteric ischemia, or intestinal obstruction. It is of the utmost importance to distinguish mesenteric fibromatosis from gastrointestinal stromal tumors. Histopathology accurately differentiates between these two distinct entities. The preferred treatment is local surgical exc

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15

Weiss, Vivian L., Cristina R. Antonescu, Rita Alaggio, et al. "Myxoinflammatory Fibroblastic Sarcoma in Children and Adolescents: Clinicopathologic Aspects of a Rare Neoplasm." Pediatric and Developmental Pathology 16, no. 6 (2013): 425–31. http://dx.doi.org/10.2350/13-06-1353-cr.1.

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16

A, Bajaji. "Adjunctive and Transformed Immunity: Histiocytic & Dendritic Cell Neoplasm." Gastroenterology & Hepatology International Journal 3, no. 1 (2022): 1–10. http://dx.doi.org/10.23880/ghij-16000139.

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Exceptional malignancies of the lymph nodes or soft tissue comprising of < 1% of the tumour incidence are the Histiocytic and Dendritic cell neoplasm. A definitive appearance/biology/ Hematology/ histopathology / exclusive therapeutic options describe the condition. Morphology and Immune reactive appraisal may be mandated to distinguish the neoplasm. Preface: Histiocytic and Dendritic neoplasms are infrequent disorders which incriminate the accessory immune system or mesenchymal cells. Subject to the origin of the neoplasm, from the bone marrow precursors or the mesenchye, the lesions may b

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17

Mohamedali, Rasheeda, Nilay Nishith, Rahul Raj, et al. "Low-grade fibromyxoid sarcoma, a rare tumor at an unusual site: Case report and review of literature." Discoveries 13, no. 2 (2025): e209. https://doi.org/10.15190/d.2025.8.

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Low-grade fibromyxoid sarcoma (LGFMS) is a rare fibroblastic neoplasm with an indolent clinical course. It is a distinctive subclass of soft tissue sarcoma with metastasizing potential and sometimes a long interval between tumor presentation and metastasis. This case report describes a 60-year-old female with an unresectable pleural LGFMS initially misdiagnosed as malignant mesothelioma. Pleural LGFMS remains exceedingly rare, with only four prior cases reported. Given its histologically benign appearance, LGFMS poses diagnostic challenges and risks of local recurrence or metastasis. This case

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18

Diaz-Beveridge, Robert, Marcos Melian, Carlos Zac, et al. "Primary Mesenteric Undifferentiated Pleomorphic Sarcoma Masquerading as a Colon Carcinoma: A Case Report and Review of the Literature." Case Reports in Oncological Medicine 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/532656.

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Undifferentiated pleomorphic sarcoma (UPS) is the most common sarcoma that appears in older patients, usually in the extremities and the retroperitoneum. Other locations are rare. By definition, in UPS, although the malignant cells tend to appear fibroblastic or myofibroblastic, they should not show differentiation towards a more specific line of differentiation. In this sense, we report the case of an 80-year-old patient with an initial clinical diagnosis of a locally advanced colonic neoplasm that was later confirmed as a primary mesenteric UPS. Primary mesenteric UPS are extremely rare with

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19

Riffle, John E., Andrea H. Prosser, Jeffery R. Lee, and Julie J. Lynn. "Nodular Fasciitis of the Orbit: A Case Report and Brief Review of the Literature." Case Reports in Ophthalmological Medicine 2011 (2011): 1–3. http://dx.doi.org/10.1155/2011/235956.

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Nodular fasciitis is a benign, reactive, fibroblastic proliferation in which nodules most commonly develop in the subcutaneous or superficial fascia of the extremities. The occurrence of these growths in the orbital region is relatively rare. Our intent is to report another orbital case of this benign fibroproliferative tumor and to provide a brief review of the pertinent medical literature. The salient pathologic features of nodular fasciitis are summarized. The potential for the misdiagnosis of these benign mesenchymal tumors as a malignant sarcomatous neoplasm is discussed. It is important

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20

Tana, Dr Yasap. "Infantile Fibrosarcoma Presenting as Neck Mass: A Case Report." Journal of Medical Science and clinical Research 12, no. 04 (2024): 10–16. http://dx.doi.org/10.18535/jmscr/v12i04.03.

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Abstract A one year old boy presented with a mass in the posterior triangle of left side of neck for ten months with rapid increase in size since one month. Radio-imaging was done. He underwent surgery, the mass was excised and the histopathological examination was done. Clinically, it was thought to be as schwannoma. Tumor measured 10 x 8 x 6 cm approximately, fixed with underlying tissue, venous prominence seen on bosselated surface and was non-tender. Microscopically, showed a cellular neoplasm composed of spindle cells arranged in herringbone pattern, also as fascicles and bundles, with fo

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21

Igrec, Jasminka, Iva Brčić, Renato Igrec, et al. "Intraarticular Nodular Fasciitis of the Knee With MHY9-USP6 Fusion: A Case Report." International Journal of Surgical Pathology 28, no. 6 (2020): 672–77. http://dx.doi.org/10.1177/1066896920908054.

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Background. Nodular fasciitis (NF) is a self-limiting, benign mesenchymal neoplasm of fibroblastic/myofibroblastic origin. Due to the fast growth, cellularity, and frequently observed high mitotic count, it is commonly misdiagnosed as a sarcoma, often resulting in overtreatment. Intraarticular examples of NF are extremely rare. Radiologically, NF can mimic fibroma of the tendon sheath, tenosynovial giant cell tumor, and synovial chondromatosis. Histology can vary from hypercellular, mitotically active lesions to fibrotic, less cellular ones, and can, therefore, mimic other benign and low-grade

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22

Drabent, Philippe, and Sylvie Fraitag. "Update on Superficial Spindle Cell Mesenchymal Tumors in Children." Dermatopathology 8, no. 3 (2021): 285–300. http://dx.doi.org/10.3390/dermatopathology8030035.

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The diagnosis of cutaneous and subcutaneous spindle cell neoplasms in children is often challenging and has potential therapeutic and prognostic implications. Although correctly diagnosing dermatofibrosarcoma protuberans and infantile fibrosarcoma is paramount, pathologists should not ignore a number of diagnostic pitfalls linked to mostly rare tumors with completely different clinical outcomes. In the last decade, a spectrum of novel entities has been described; information from molecular biology has helped to shape this new landscape for spindle cell tumors. Here, we review the most notewort

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23

Renuka Bangalore Nagaraj, Anil Kumar Moodalbeedu Rajegowda, Murali Paramanandhan, Shivanna, and Basavarajaiah Doddagangavadi Mariyappa. "The practical approach of Immuno histochemical markers in Solitary Fibrous Tumour (SFT)." World Journal of Advanced Research and Reviews 13, no. 2 (2022): 325–30. http://dx.doi.org/10.30574/wjarr.2022.13.2.0095.

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A solitary fibrous tumour is an unknown neoplasm that is fibroblastic in nature. It causes diagnostic difficulty due to its unexpected Immunophenotypic appearance as well as wide histologic appearance, but most of the time it is accurately diagnosed due to its histological characteristics and strong positivity to CD34 expression.SFT is known to occur in almost all parts of the body including meninges and skin. This is a slow-growing neoplasm that can be successfully treated by complete excision; the malignant counterpart of SFT is rare. The most important and reliable positive markers in SFT a

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24

Phillips, Rebecca, and Sumit Das. "Desmoplastic small round cell tumor of the pleura with brain metastasis: A case report and literature review." Journal of Case Reports and Images in Pathology 9, no. 2 (2023): 5–12. http://dx.doi.org/10.5348/100074z11rp2023cr.

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Introduction: Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive mesenchymal neoplasm characterized by a chromosomal translocation involving the EWSR1 and WT1 genes. It typically arises in intra-abdominal tissues (i.e., mesentery, omentum, pelvic organs), and commonly spreads to regional lymph nodes, lungs, or liver, while central nervous system (CNS) metastasis is rare. Case Report: We present a unique case of DSRCT originating from the pleura in a young female, which was metastatic to intrathoracic and mediastinal tissue at diagnosis and later spread to the brain. The initi

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Choi, Joon Hyuk. "Inflammatory Myofibroblastic Tumor: An Updated Review." Cancers 17, no. 8 (2025): 1327. https://doi.org/10.3390/cancers17081327.

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Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm that is characterized by a proliferation of myofibroblastic and fibroblastic spindle cells, accompanied by an inflammatory infiltrate that is abundant in plasma cells, lymphocytes, and eosinophils. IMT can arise in various anatomical locations but most commonly occurs in the abdominal cavity, retroperitoneum, and lung, particularly in children and young adults. IMT typically demonstrates local invasion or recurrence, whereas metastasis is rare. IMTs pose a diagnostic challenge because of their overlapping morphological characteristics

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Negură, Ion, Victor Ianole, and Radu Dănilă. "Primary solitary fibrous tumor of the thyroid gland: A review starting from a case report." Archive of Clinical Cases 8, no. 4 (2021): 97–105. http://dx.doi.org/10.22551/2021.33.0804.10193.

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Primary solitary fibrous tumor (SFT) of the thyroid gland is a rare mesenchymal tumor with fibroblastic differentiation, ramified, thin-walled, enlarged (staghorn) vessels and specific NAB2-STAT6 gene fusion, which is more commonly found in pleura and peritoneum. This neoplasm can be located in a variety of anatomical sites outside pleura and peritoneum including bone, visceral organs and soft tissues, head and neck examples representing only 10-15% of the extra-pleural and extra-peritoneal tumors. Diagnosing this entity can be difficult, especially in thyroid gland, mainly because of the rari

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27

Renuka, Bangalore Nagaraj, Kumar Moodalbeedu Rajegowda Anil, Paramanandhan Murali, Shivanna, and Doddagangavadi Mariyappa Basavarajaiah. "The practical approach of Immuno histochemical markers in Solitary Fibrous Tumour (SFT)." World Journal of Advanced Research and Reviews 13, no. 2 (2022): 325–30. https://doi.org/10.5281/zenodo.6349797.

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A solitary fibrous tumour is an unknown neoplasm that is fibroblastic in nature. It causes diagnostic difficulty due to its unexpected Immunophenotypic appearance as well as wide histologic appearance, but most of the time it is accurately diagnosed due to its histological characteristics and strong positivity to CD<sub>34</sub> expression.SFT is known to occur in almost all parts of the body including meninges and skin. This is a slow-growing neoplasm that can be successfully treated by complete excision; the malignant counterpart of SFT is rare. The most important and reliable positive

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28

Medeiros, Augusto Kreling, Cinthia Callegari Barbisan, Isaac Torres de Carvalho, Ulysses dos Santos Torres, and Carlos Eduardo Bacchi. "Fibroblastic reticular cell tumour of the internal iliac lymph node presenting as a hypervascular lesion and mimicking a pseudoaneurysm: an extremely rare diagnosis." BMJ Case Reports 16, no. 4 (2023): e252280. http://dx.doi.org/10.1136/bcr-2022-252280.

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A woman in her 50s presented with a rounded and hypervascular lesion in the right internal iliac lymph node chain, contacting with small branches of the anterior division of the internal iliac artery. Since the lesion matched the blood arterial pool in CT and the patient exhibited multiple vascular abnormalities that suggested segmental arterial mediolysis, a pseudoaneurysm hypothesis was initially made. Arteriography was realised due to the intention for embolisation of the pseudoaneurysm, but the dynamic behaviour during the exam suggested a hypervascular tumour more. An MRI was conducted, b

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HN, Arun, Chaitra, Srinivas NM, and Ravi Savasere. "Myxofibrosarcoma of neck: A rare case." IP Journal of Diagnostic Pathology and Oncology 7, no. 2 (2022): 103–6. http://dx.doi.org/10.18231/j.jdpo.2022.024.

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Myxofibrosarcoma (MFS) is commonly seen among elderly patients, usually sixth to eighth decade of life. Most of these tumours arise in the extremities (lower limbs &#62; upper limbs) and are less commonly seen on the Trunk, Head and Neck, Retroperitoneum and Pelvic areas. The World Health Organization (WHO) defines MFS as the malignant fibroblastic neoplasm characterized by cellular pleomorphism, variably prominent myxoid stroma, and prominent elongated, thin-walled stromal blood vessels. Head Neck MFS is rare site of occurrence with 19 cases reported worldwide till date, described subsite

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30

Dandala, Sridhar R., Achyuth Panuganti, and Pindicura Kumuda. "Atypical Spindle Cell Lesion of Larynx: A Rare Benign Condition mimicking Malignancy." International Journal of Phonosurgery & Laryngology 7, no. 1 (2017): 31–35. http://dx.doi.org/10.5005/jp-journals-10023-1139.

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ABSTRACT Atypical spindle cell lesion of larynx is a very rare condition usually misdiagnosed as malignant spindle cell tumor, requiring immunohistochemical (IHC) studies for reaching a correct diagnosis. We present a case of a 75-year-old male patient, who presented to the ear, nose, and throat casualty in stridor, and was tracheostomized. Videolaryngoscopy revealed a huge irregular growth filling the supraglottis. Biopsy of the growth suggested a reactive fibroblastic proliferation with atypia. The patient was again subjected to biopsy and it revealed well-differentiated squamous cell carcin

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31

Portenko, M., and O. Shchebentovska. "Clinic and anatomic aspects of verification and monitoring of various types of equine sarcoid in the western regions of Ukraine." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 25, no. 109 (2023): 114–24. http://dx.doi.org/10.32718/nvlvet10918.

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Sarcoid is the most common skin tumor reported worldwide in equids, donkeys, zebras, and mules of all ages and sexes. The bovine papillomavirus (BPV) plays an important role in the pathogenesis of the disease. Globally, the incidence of equine sarcoid ranges from 12 % to 67 % of all skin neoplasms. Unfortunately, no attention is paid to the study of sarcoid epizootology in Ukraine. There are no reports on the clinical types of neoplasms, their pathohistological characteristics, and treatment methods. Our study aimed to describe the clinical manifestations of different anatomical types of equin

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Hamza, Hazwa Karathanathodi, Nausheen Yaqoob, Asim Qureshi, Mirza Amanullah Beg, Prashant Deshpande, and Ibrahim Al Haddabi. "A Case of Sporadic Desmoid Fibromatosis of the Appendix: A Rare Site of Presentation." Saudi Journal of Pathology and Microbiology 9, no. 12 (2024): 260–65. https://doi.org/10.36348/sjpm.2024.v09i12.002.

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Background: Desmoid fibromatosis is a locally aggressive benign fibroblastic soft tissue tumor representing nearly 0.03% of all neoplasms. They can be sporadic or may be associated with Familial Adenomatous Polyposis (FAP). Around 50% of fibromatosis are intrabdominal or arise in the abdominal wall. Rarely, these tumors can arise from the intestinal wall. Appendix and mesoappendix are extremely rare sites of presentation with only 3 reported cases. Case Presentation: A healthy 43-year-old male presented with abdomen distension. CECT scan showed a well-defined enhancing mass in the lower abdome

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Sorokin, N. I., V. K. Dzitiev, A. V. Kadrev, et al. "Undifferentiated pleomorphic prostate sarcoma: a rare clinical case and systematic literature review." Cancer Urology 20, no. 1 (2024): 116–33. http://dx.doi.org/10.17650/1726-9776-2024-20-1-116-133.

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Undifferentiated pleomorphic prostate sarcoma is an extremely rare neoplasm. In the available literature, less than 50 clinical cases were described. Usually, the clinical manifestation of the disease is nonspecific and is primarily associated with bladder outlet obstruction. Additionally, most patients have normal levels of prostate-specific antigen, while ultrasound and MRI can visualize irregularly shaped lesions, often extending beyond the prostate gland. Diagnosis requires exclusion of other signs of specific differentiation, apart from fibroblastic and myofibroblastic. There is no establ

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Mücke, Ralph, Berthold Reichl, Oliver Micke, et al. "Surgery and radiotherapy of one rare case with neoplasm derived from fibroblastic reticulum cells of a cervical lymph node." Acta Oncologica 43, no. 8 (2004): 766–68. http://dx.doi.org/10.1080/02841860410018610.

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Taher, Altaf, and Chitra Pushpanathan. "Plexiform Fibrohistiocytic Tumor: A Brief Review." Archives of Pathology & Laboratory Medicine 131, no. 7 (2007): 1135–38. http://dx.doi.org/10.5858/2007-131-1135-pftabr.

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Abstract Plexiform fibrohistiocytic tumor is a rare mesenchymal neoplasm of intermediate malignancy, first reported by Enzinger and Zhang in 1988. It has a predilection for children and young adults but can occur at any age. The tumor usually involves the upper limbs as a slow-growing, painless mass. The tumor has a high local recurrence rate but metastasizes only rarely. Histologically, the tumor is characterized by poorly demarcated dermal or subcutaneous mass with multinodular plexiform growth and fibrohistiocytic cytomorphology. There are three distinct recognized growth patterns: fibrohis

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Cazzato, Gerardo, Anna Colagrande, Antonietta Cimmino, et al. "Pleomorphic Hyalinizing Angiectatic Tumor (PHAT): Review of the Literature with Case Presentation." Dermatopathology 8, no. 2 (2021): 97–102. http://dx.doi.org/10.3390/dermatopathology8020015.

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Pleomorphic hyalinizing angiectatic tumor (PHAT) is a very rare entity of soft tissue considered a “neoplasm of uncertain behaviour of connective or other soft tissue” by the World Health Organization (2020). It develops in subcutaneous tissue of the lower extremities, more frequently in the region of the ankle and foot, and rarely as a deep-seated soft tissue mass in locations such as the perineum, buttock, arms, head and neck, and viscera. Although inconsistent cytogenetic data have been reported on PHAT so far, there are potential morphological and genetic overlaps with hemosiderotic fibrol

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González, Carlos Juan Puig, Juan Carlos Puig Chong, and Lianet Castro Bolano. "Low grade mixofibrosarcoma in the mandible: A case report." Journal of Otolaryngology-ENT Research 13, no. 2 (2021): 18–20. http://dx.doi.org/10.15406/joentr.2021.13.00484.

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Introduction: The term myxofibrosarcoma (MFS) and myxosarcoma refers to a neoplasm of connective tissue of fibroblastic origin, formerly called malignant fibrous histiocytoma. Objective: To describe the clinical characteristics and the surgical medical procedure carried out. Clinical case: 61-year-old male patient, with a history of relative previous health and a 2-year history with a lesion in the marginal gingiva. Bulging of both cortices and with an extension of the lower right to the left first premolar. Therefore, they are admitted for a better study and treatment. Conclusions: It is a re

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Kurtz, Jean-Emmanuel, Irène Asmane, Anne-Claire Voegeli, et al. "A V530I Mutation in c-KIT Exon 10 Is Associated to Imatinib Response in Extraabdominal Aggressive Fibromatosis." Sarcoma 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/458156.

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Aggressive fibromatosis (AF) or desmoid tumor is a rare condition, characterized by deep tissue invasion by a monoclonal fibroblastic neoplasm, developed from musculoaponeurotic structures. Surgery is the treatment of choice, but negative margins can hardly been achieved in large tumors, and can lead to major functional disability. AF medical therapy includes nonsteroids anti-inflammatory drugs, tamoxifen, with inconsistent results. Several reports of imatinib efficacy in AF appear in the literature. Here, we describe for the first time a V530IKITexon 10 mutant that was associated to a dramati

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Paudyal, Punam, M. Agarwal, A. Pradhan, A. K. Sinha, A. K. Karak, and R. Agarwal. "Multicystic Nephroma-Report of Two Rare Cases in a Span Of Seven Years." Health Renaissance 12, no. 3 (2016): 227–29. http://dx.doi.org/10.3126/hren.v12i3.15327.

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Background: Multicystic nephroma (MCN) is an uncommon but distinctive benign pediatric renal neoplasm but may present clinically at any age. It is scantily reported in the literature. To the best of our knowledge it has not yet been reported from Nepal. It is characterized by a well circumscribed mass with nodular outer surface that contain multiple fluid filled locals. Microscopy show cystically dilated spaces lined by flattened to columnar epithelium and is separated by fibroblastic stroma. A hobnail pattern is common.Case description: Here we report two cases of multicystic nephroma in a sp

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Fu, Zhiyan, Evita B. Henderson-Jackson, Barbara A. Centeno, et al. "A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature." Case Reports in Pathology 2023 (February 9, 2023): 1–5. http://dx.doi.org/10.1155/2023/2271690.

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A 73-year-old man with a history of atrial myxoma and basal cell carcinoma presented with unexplained fever. Contrast-enhanced CT abdomen showed a large left hepatic lobe mass with early enhancement and delayed venous washout, concerning for hepatocellular carcinoma. Fine needle aspiration showed numerous spindle cells with malignant nuclear features, suggestive of malignant spindle cell neoplasm. The patient underwent left hepatectomy. The surgical specimen showed a well-circumscribe solid mass ( 14.6 × 13.0 × 10.0 cm ) with necrosis. Histopathological examination revealed a proliferation of

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Lee, Bo Hyun, Lan Sook Chang, Youn Hwan Kim, Chang Hun Lee, and Seong Oh Park. "Flexor Digitorum Superficialis to Flexor Digitorum Profundus Tendon Transfer after Wide Excision of Myxoinflammatory Fibroblastic Sarcoma: A Case Report." Journal of Wound Management and Research 20, no. 2 (2024): 178–83. http://dx.doi.org/10.22467/jwmr.2024.02908.

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low-grade soft tissue neoplasm that typically arises in the extremities. A 72-yearold woman presented with recurrent masses on her left forearm. Four years prior, she underwent an excisional biopsy, diagnosed as MIFS, followed by wide excision and split-thickness skin graft coverage. Preoperative magnetic resonance imaging was conducted for the recurrent mass, revealing multiple tumors invading the flexor digitorum profundus (FDP) muscle and fascia. The tumors including most of the FDP muscle were therefore excised. The third flexor digit

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Gros, Louis, Angelo Paolo Dei Tos, Robin L. Jones, and Antonia Digklia. "Inflammatory Myofibroblastic Tumour: State of the Art." Cancers 14, no. 15 (2022): 3662. http://dx.doi.org/10.3390/cancers14153662.

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An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, including lymphocytes and eosinophils. It is an ultra-rare tumor, the optimal management of which remains to be defined. Surgery is the treatment of choice for localized tumors. The treatment of advanced disease is not precisely defined. Chemotherapy regimens result in an overall response rate of approximately 50% based on retrospective data. The latest pathophysiological data highlight the role played by tyrosine kinase fusion genes in IMT pro

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Mohan, Vipin, Janarthanan Ramu, Balu C. Babu, Druvan P. Shaji, K. K. Chandrababu, and Subramaniya Iyer. "Recurrent Abdominal Aggressive Fibromatosis with Incapacitating Hip Contracture – A Case Report." Journal of Orthopaedic Case Reports 13, no. 10 (2023): 38–41. http://dx.doi.org/10.13107/jocr.2023.v13.i10.3928.

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Introduction: Aggressive fibromatosis (AF) is a fibroblastic locally aggressive neoplasm arising from the musculoaponeurotic stroma and has no metastatic potential. The high tendency of recurrence despite complete surgical resections makes the management of the condition onerous. It can result in significant morbidity with major functional loss due to the destruction of adjacent vital structures and organs. AF with hip flexion contracture is a very rare occurrence. Case Report: A 20-year-old male presented with recurrent abdominal AF with severe hip flexion contracture and an unresectable tumo

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Kanteti, A. P., and E. Martinez Duarte. "A Rare Case of Dedifferentiated Solitary Fibrous Tumor." American Journal of Clinical Pathology 154, Supplement_1 (2020): S42. http://dx.doi.org/10.1093/ajcp/aqaa161.089.

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Abstract Casestudy: Dedifferentiated solitary fibrous tumor is a rare malignant subtype of the common benign mesenchymal neoplasm with fibroblastic differentiation known as solitary fibrous tumor (SFT). These account for less than 2% of all soft masses; and about 20% of SFTs turn aggressive. They feature bland spindle cells creating a classic “pattern-less pattern” in collagenous stroma with prominent staghorn vessels. They can dedifferentiate into a biphasic tumor with low grade areas that are spindle cell rich and high-grade areas with epithelioid cells, mitotic figures and necrosis. Here we

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Bharadwaj, H., and J. Freeman. "EBV+ Inflammatory Pseudotumor-like Follicular/Fibroblastic Dendritic Cell Sarcoma: An Uncommon and Challenging Tumor." American Journal of Clinical Pathology 154, Supplement_1 (2020): S77—S78. http://dx.doi.org/10.1093/ajcp/aqaa161.169.

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Abstract Casestudy: Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma (IP-L FDC/FRC) is a rare dendritic cell neoplasm recognized as a specific entity in the WHO classification of tumors of the hematopoietic and lymphoid tissues. The tumor has specific clinical features, including a predominance in young to middle-aged women typically involving the liver or spleen, with neoplastic cells typically positive for Epstein-Barr virus. Morphologically, the tumor poses a diagnostic challenge to distinguish it from inflammatory pseudotumor and inflammatory myofibroblastic tum

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Tahir, M., T. Phung, and T. Nguyen Luu. "ONYCHOMATRICOMA, A RARE NAIL TUMOR." American Journal of Clinical Pathology 162, Supplement_1 (2024): S29—S30. http://dx.doi.org/10.1093/ajcp/aqae129.064.

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Abstract Introduction/Objective Nail apparatus tumors are rare and can pose diagnostic challenges. Onychomatricoma (also called onychomatrixoma) is a rare tumor first described in 1992. It is a benign biphasic fibroepithelial tumor of the nail. It has been reported in Caucasians, often in females with a peak incidence in the fifth decade of life. Rare cases are also reported in children. The common location is in the fingernail (75%), presenting with yellowing of the nail plate (xanthonychia) and thick longitudinal band. Cutaneous horn, melanonychia, nail bleeding, and nail deformity with or w

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Хоров, О. Г., Е. И. Никита, О. В. Загоровская, А. Г. Новиков, and А. С. Нечипоренко. "Desmoid Fibromatosis of Nasal Cavity and Paranasal Sinuses. Description of the Clinical Case." Оториноларингология. Восточная Европа, no. 3 (November 25, 2020): 258–67. http://dx.doi.org/10.34883/pi.2020.10.3.049.

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Десмоидная фиброма (агрессивный фиброматоз) является редкой доброкачественной фибробластической опухолью, характеризующейся агрессивным локальным ростом, частым рецидивированием, отсутствием способности к метастазированию. В зависимости от локализации подразделяется на интра- и экстраабдоминальные. В числе последних десмоиды области головы и шеи составляют 7–15% (у взрослых) и крайне редко встречается в полости носа и околоносовых пазух. Единой общепринятой тактики лечения пациентов с десмоидными фибромами не разработано ввиду редкости патологии и отсутствия обобщенных ретроспективных исследов

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Fugere, Tyler, Brad Fugere, Fnu Amisha, et al. "Interdigitating Dendritic Cell Sarcoma and Indeterminate Dendritic Cell Tumor: Patient Characteristics, Prognostic Factors, and Survival Outcomes for Rare Dendritic Cell Neoplasms." Blood 142, Supplement 1 (2023): 5346. http://dx.doi.org/10.1182/blood-2023-187700.

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Background Dendritic cells are nonlymphoid, nonphagocytic, antigen-presenting cells present in lymphoid and nonlymphoid tissue. There are 4 types of dendritic cells: follicular, interdigitating, Langerhans, and fibroblastic cells. The WHO 2022 classification system groups dendritic cell and histiocytic neoplasms into 3 categories: plasmacytoid dendritic cell neoplasms, Langerhans cell and other dendritic cell neoplasms, and histiocytic neoplasms. The 2nd category is subdivided into “Langerhans cells neoplasms” and “other dendritic cell neoplasms”, which contains indeterminate dendritic cell tu

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Lewin, Eleanor, Philip Daroca, Sanjay Sikka, Tong Wu, and Yukihiro Nakanishi. "Gastric Adenocarcinoma of the Fundic Gland Type Treated by Endoscopic Mucosal Resection: A Case Report and Review of the Literature." Case Reports in Pathology 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/8646927.

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Gastric adenocarcinoma of the fundic gland type (GA-FG) is a rare entity that has only recently been described and defined. There is ongoing controversy regarding the malignant potential of this lesion. We report the case of a GA-FG in a 49-year-old Caucasian man who was referred to endoscopy for management of an incidentally found gastric polyp. Endoscopy showed a single polypoid lesion in the gastric fundus which was successfully removed with endoscopic resection. Grossly, the polyp measured 1.1 cm in greatest dimension. Microscopic examination showed irregularly branched neoplastic glands c

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Yang, Xingrong, Sitong Guo, Ke Meng, and Juan Tao. "Invasive inflammatory fibroid polyp of the stomach: A case report and literature review." Medicine 104, no. 7 (2025): e41308. https://doi.org/10.1097/md.0000000000041308.

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Rationale: Inflammatory fibrous polyp (IFP) is a distinct fibroblastic neoplasm with a predilection for the stomach and ileum. It usually presents prominent inflammatory infiltration, particularly eosinophils, and has been widely considered benign tumors without malignant biological behaviors. However, rare invasive cases have been reported. Patient concerns: A 75-year-old woman presented with unexplained hematemesis, dizziness, and weakness for 3 hours. Physical examination revealed upper abdominal tenderness on palpation. Diagnoses: Contrast-enhanced computed tomography revealed a 6 cm nodul

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