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Dissertations / Theses on the topic 'Rat locomotion/brain receptors'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Coles, S. K. "Controls of the locomotor system in the rat." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233493.

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2

Boulay, Denis. "Etude chez le rat des modifications comportementales et neurochimiques après administrations répétées d'agonistes dopaminergiques indirects : la cocaïne ou le GBR12783." Rouen, 1995. http://www.theses.fr/1995ROUE5042.

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Nous avons recherché si un blocage répété du système de capture de la dopamine par un inhibiteur spécifique de la capture neuronale de dopamine, le GBR12783, pouvait mimer les sensibilisations observées après administrations de cocaïne, inhibiteur non sélectif de la recapture des monoamines. Des administrations répétées de GBR12783 ont induit une sensibilisation à ses effets stimulants moteurs, se développant au cours du temps et pouvant persister plusieurs semaines après la dernière administration. L'expression de cette sensibilisation dépend en partie de la durée des traitements chroniques ;

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3

Cohen, Ricky Israel. "Rat brain oligodendrocytes express muscarinic and adrenergic receptors." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42006.

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The aim of the studies underlying this thesis was to characterize the muscarinic and adrenergic receptors expressed in rat brain oligodendrocytes' (OLs); determine if ligand binding alters second messenger levels classically associated with these families of receptors, such as inositol phosphates (InsP), intracellular calcium ( (Ca$ rm sp{2+} rbrack sb{i}),$ and cyclic AMP (cAMP); and the role of neurotransmitters, acetylcholine (Ach) or norepinephrine (NE) on oligodendrocyte growth.<br>CCH (carbachol), a stable Ach analog, caused a concentration and time dependent increase in the accumulation

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4

Cohen, Ricky Israel. "Rat brain oligodendrocytes express muscarinic and adrenergic receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0022/NQ29913.pdf.

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5

Mahalekam, Malani. "Natriuretic peptide receptors in developing and adult rat brain." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368618.

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6

Howard, Helen Clare. "The pharmacological characterisation of oxytocin receptors in the rat brain." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299594.

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7

Pasquini, Filoteo. "High resolution radioautographic visualization of delta opioid receptors in rat brain." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=64051.

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8

Smith, Steven Andrew. "The role of Peroxisome proliferator-activated receptors in the rat brain /." St. Lucia, Qld, 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17982.pdf.

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9

Gibbins, Jonathan Martin. "The purification of corticotropin-releasing factor (CRF) receptors from rat brain." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260813.

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10

Schindler, Marcus. "The distribution of somatostatin receptors in the rat and human brain." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627298.

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11

Kelly, Mary D. W. "The ontogeny of delta and kappa opioid receptors in the rat." Thesis, University of Surrey, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318690.

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12

Large, Charles Henry. "Characterisation of dopamine D3 receptors in recombinant cell lines and rat brain." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388037.

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13

Wang, Li Racine Ronald J. "Expression of EphA receptors and ligands in rat brain following status epilepticus." *McMaster only, 2006.

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14

Mason, Sarah. "Post-mortem neuropharmacological studies of human and rat brain relating to schizophrenia and antipsychotic drug action." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364237.

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15

Nemati, Farshad, and University of Lethbridge Faculty of Arts and Science. "Contribution of brain with or without visual cortex lesion to exploratory locomotion in the rat." Thesis, Arts and Science, 2008. http://hdl.handle.net/10133/665.

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Over the past five decades spatial behavior has been a subject of research interest in psychology and neuroscience, in part based on philosophical theories of mental spatial representations. In order to continue uncovering the facts regarding spatial behavior, the focus of this thesis was on the contribution of entry point and visual inputs to the organization of exploratory locomotion and spatial representation in the rat. Despite the contribution of the hippocampus to spatial abilities, the exploratory locomotion is still visually organized in rats with damage to the hippocampus. On the othe

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16

Ma, Guofen. "Functional responses of pre- and postsynaptic dopamine D2 receptors in rat brain striatum." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/283893.

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El sistema dopaminèrgic has estat molt estudiat en els darrers anys, principalment degut a la seva implicació en diverses patologies com la malaltia de Parkinson, la esquizofrènia o la síndrome de Tourette, així com també en l’abús de drogues. S’han descrit cinc subtipus de receptors per la dopamina (DA), tots els quals pertanyen a la família de receptors acoblats a proteïnes G (GPCRs). D’aquests cinc subtipus, els receptors D2 son la diana principal dels antipsicòtics (antagonistes) i també dels fàrmacs utilitzats en el trastament del Parkinson (agonistes). Malauradament, els efectes antagoni

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17

McFadzean, I. "Kappa opioid actions in the rat locus coeruleus in vitro." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233318.

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Intracellular recordings were made from neurones of the rat locus coeruleus (lc) contained within a brain slice maintained <i>in vitro</i>. When applied to the slice in known concentrations, K opioid receptor agonists produced a concentration-dependent, naloxone-reversible depression of the electrically evoked excitatory post-synaptic potential (epsp). This effect of K agonists was observed in the absence of changes in the membrane potential or input resistance of the post-synaptic cell. Similarly, the K agonists had no effect on the tetrodotoxin-resistant action potential waveform. Naloxone a

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18

Leonard, M. N. "Studies on the potential heterogeneity of D2Ì² dopamine receptors from bovine and rat brain." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381474.

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19

Perron, Amélie. "NTS2 neurotensin receptors : distribution, interactions, and cellular dynamics in model systems and rat brain." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102692.

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Although available evidence suggests that NTS1 receptors play a key role in the transduction of many of the central effects of neurotensin (NT), recent data indicate that the NTS2 subtype may be responsible for mediating NT-induced analgesia. However, little is known about the cellular and molecular mechanisms underlying NTS2 function. It is also unclear whether endogenous NT is an agonist at the NTS2 site and to which second messenger system(s) this receptor is coupled since conflicting data has emerged from studies carried out in systems heterologously expressing the NTS2 receptor. In this c

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20

Gerova, Nadezhda [Verfasser]. "Expression of angiotensin receptors in the rat brain after focal cerebral ischemia / Nadezhda Gerova." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1071087770/34.

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21

Prunell, dos Santos Giselle F. "Pathophysiology of subarachnoid hemorrhage in the rat /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-610-3/.

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22

Gruber, Susanne H. M. "Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain /." Stockholm : [Karolinska institutets bibliotek], 2002. http://diss.kib.ki.se/2002/91-7349-229-9.

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23

Alex, Katherine D. "5-HT2C SEROTONIN RECEPTORS: CELLULAR LOCALIZATION AND CONTROL OF DOPAMINERGIC PATHWAYS IN THE RAT BRAIN." Connect to text online, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1164766901.

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24

Yi, Chenju [Verfasser], and H. J. [Akademischer Betreuer] Schlüsener. "Sweet Taste Receptors in Normal and Pathological Rat Brain / Chenju Yi ; Betreuer: H. J. Schlüsener." Tübingen : Universitätsbibliothek Tübingen, 2011. http://d-nb.info/1161464638/34.

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25

Woodhall, Gavin Lawrence. "The role of glutamate receptors at the CA3/CA1 Schaffer collateral/commissural synapse of rat hippocampus." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295902.

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26

Chong, Victor Z. Mishra Ram K. "Differential regulation of synapsin II expression by dopamine-D1 and -D2 receptors in the rat brain /." [Hamilton, Ont.] : McMaster University, 2005.

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27

Leventopoulos, Michail. ""Long-term effects of the postnatal environment on brain glia and monoamine receptors in the rat"." Thesis, Roehampton University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515146.

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28

Evans, Ian Michael. "Maternal hypothyroxinemia and the ontogeny of thyroid hormone nuclear receptors and cholinergic and monoaminergic neurotransmitter systems in developing rat brain." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322515.

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29

Szigethy, Eva Maria. "Cellular and subcellular radioautographic localization of neurotensin receptors to chemically-identified neuronal subpopulations in the rat brain." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74216.

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Neurotensin (NT) is a putative neurotransmitter, the central actions of which appear to be mediated by specific high affinity binding sites. Radioautographic studies using emulsion-coated sections have selectively localized a major proportion of NT binding sites over nerve cell bodies in the rat midbrain tegmentum and basal forebrain. In the present studies, it was shown that the vast majority of $ sp{125}$I-NT-labeled neurons in the rat midbrain tegmentum were dopaminergic, while those in the magnocellular basal forebrain of both rats and humans were predominantly cholinergic using adjacent-s

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30

Tiger, Gunnar. "Signal transduction in the brain : modulation of receptor-mediated inositol phospholipid breakdown by potassium and fluoride ions." Doctoral thesis, Umeå universitet, Farmakologi, 1990. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68968.

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Neurotransmitter receptor types mediating the generation of intracellular signals are of two types; ligand-gated ion channels and G protein coupled receptors. The effector enzyme phosphoinositide-specific phospholipase C (PLC) is modulated by stimulation of G protein coupled receptors, leading to an increased breakdown of inositol phospholipids ("Ptdlns breakdown").In recent years, the receptors in the brain coupled to PLC and modulation of such receptor-mediated Ptdlns breakdown have been characterised. One such modulation is the "potassium effect", whereby an increase in the assay [K+] from

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31

Ayman, GoÌˆher. "Dynamic aspects of the control of excitatory transmission by metabotropic glutamate receptors at cortical synapses of rat brain." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414358.

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32

Nunn, Elizabeth de Fourgerolles. "The characterisation of oestrogen receptors by gel filtration in hormone-sensitive tissues : immature rat uterus, brain and thymus." Thesis, Open University, 1999. http://oro.open.ac.uk/57989/.

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The aims of this project were to investigate the binding characteristics of the cytosolic oestrogen receptor in the uterus, brain and thymus of immature Wistar rats. The specificities of the receptor in the uterus are well established. The specificities of the cytosolic receptor in the uterus and thymus of immature female Wistar rats were tested against a range of steroids and the values found for the thymus compared with those for the uterus. The concentrations and dissociation constant (Kd) of the cytosolic oestrogen receptor were determined in uterus, brain and thymus of male and female rat

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33

Caberlotto, Laura. "Distribution and regulation of neuropeptide Y and its receptors in the human and rat brain : role in affective disorders /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3310-3.

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34

Subramaniam, Sabarinath. "Studies on the expression of synaptic terminal proteins and neurotransmitter receptors in the rat brain following amphetamine-induced behavioral sensitization." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq64462.pdf.

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35

Lecours, Maurice. "Electrophysiological Investigations on the Role of Selected Serotonin Receptors and the Serotonin Transporter on Serotonin Transmission in the Rat Brain." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30400.

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This study assessed the in vivo effects of various serotonin (5-HT) receptor modulators on 5-HT neurotransmission in the rat hippocampus. Vortioxetine, humanized-vortioxetine, and escitalopram blocked the 5-HT transporter, but similar to ipsapirone did not dampen the sensitivity of postsynaptic 5-HT1A receptors. Long-term administration of all treatments increased the tonic activation of postsynaptic 5-HT1A heteroreceptors, an effect common to all antidepressants. Vortioxetine decreased the function of the terminal 5-HT1B autoreceptor under high but not a low degree of activation, thus showing

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36

Apaydin, Serpil. "Effect Of Lipids On Binding Characteristics Of Opioid Receptors." Phd thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12605971/index.pdf.

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Effect of lipids on binding characteristics of opioid receptors in membranes prepared from rat brain were studied. Lipid concentrations causing changes in specific binding of [3H]Endomorphin-1 (ProE1), an opioid agonist highly specific to mu-type opioid, [3H]Ile5,6deltorphin II (DIDI), an agonist ligand highly specific to delta type receptor and [3H]Naloxone (Nlx), a universal opioid receptor antagonist were determined. Inhibition of [3H]ProE1, [3H]DIDI and [3H]Nlx specific binding was also examined by homologous displacement experiments in the presence and absence of lipids. In order to under

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37

Dwyer, Daniel, and na. "Serotonin as a Mediator of Fatigue During Exercise and Training." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040521.130535.

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Exercise has been shown to cause an increase in the concentration of brain serotonin (5-hydroxytryptamine, 5-HT) in humans and experimental animals. The increase in brain serotonin coincides with the onset of fatigue and is referred to as "central fatigue". Experiments in humans and animals involving serotonin receptor agonists have demonstrated reductions in exercise performance by simulating the exercise-induced increase in endogenous serotonin. Conversely, the administration of serotonin receptor antagonists has been shown to extend exercise performance in experimental animals, but not in h

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38

Roulston, Carli L. (Carli Lorraine) 1973. "Localization of both type 2 angiotensin II receptors and a non-angiotensin II binding site by [125 I] CGP42112 in rat brain stem." Monash University, Dept. of Pharmacology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8844.

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39

Beauvais, Geneviève. "Molecular and cellular bases for the protective effects of dopamine D1 receptor antagonist, SCH23390, against methamphetamine-induced neurotoxicity in the rat brain." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00691924.

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Methamphetamine (METH) is a potent psychostimulant known to cause cognitive abnormalities and neurodegenerative changes in the brains of METH abusers. One approach for developing therapies for METH abuse is to understand the molecular mechanisms of toxicity of the drug. Investigations in our laboratory and elsewhere have shown that single intraperitoneal injections of METH (30-40 mg/kg of body weight) can cause damage to striatal and cortical monoaminergic systems and induce neuronal apoptosis in the striatum of rodents via activation of endoplasmic reticulum (ER) and mitochondrial death pathw

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40

Bhindi, Amar. "Immuno-histochemical study of somatostatin receptors and the Golgi-associated protein PIST in the rat brain - the cellular and sub-cellular distributions, and their potential implications in receptor regulation." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114438.

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Somatostatin (SOM) is a neuropeptide fulfilling numerous physiological and neuro-modulatory functions throughout the body and brain. Its actions are mediated through a family of G Protein-coupled receptors (GPCRs), designated sst1-5, which are differentially regulated. While in vitro studies have previously demonstrated that the co-expression of several SOM receptor subtypes in cell lines has influence over receptor regulation and trafficking, this has yet to be confirmed in situ. Moreover, SOM receptors carry on their C-terminal ends, PDZ-binding motifs that mediate dynamic interactions betwe

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41

Uys, Joachim De Klerk. "The effects of early life trauma on the neurochemistry and behaviour of the adult rat." Thesis, Link to the online version, 2006. http://hdl.handle.net/10019/1249.

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42

Lafaille, Francine. "Characterization of [125I]7-amino-8-iodo-ketanserin binding and comparative effects of long-term treatment with anxiolytic and antidepressant drugs on serotonin type 2 and beta-adrenergic receptors in rat brain." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60548.

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Changes to 5-HT$ sb2$ receptors in rat brain following antidepressant and anxiolytic treatment were investigated. The B$ sb{ rm max}$ of ($ sp{125}$I) AMIK was found to be decreased significantly in rat fronto-parietal cortex after 21 days administration of antidepressant drugs including desmethylimipramine (30%), buspirone (47%) and adinazolam (17%). The anxiolytic drug, diazepam, which is devoid of intrinsic antidepressant action, did not significantly change the binding parameters. In comparison to 5-HT$ sb2$ receptors, the beta-adrenoceptors labelled by ($ sp{125}$I) cyanopindolol in membr

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43

Balaños, Guzman Carlos Alberto. "The effects of the kappa agonist U-50,488 on morphine-induced place preference conditioning and Fos immunoreactivity in the preweanling and periadolescent rat." CSUSB ScholarWorks, 1995. https://scholarworks.lib.csusb.edu/etd-project/1074.

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The effects of the kappa opioid agonist U-50,488 on morphine-induced condtioned place preference (CPP), locomotor activity and Fos immunoreactivity and assessed in 10-, 17- and 35-day old rats. It was predicted that kappa agonist treatment would block the unconditioned and conditioned behaviors produced by morhine (a mu opioid receptor agonist).

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44

Degoulet, Mickaël. "Implication de la neurotransmission glutamatergique dans la sensibilisation comportementale à court terme aux amphétamines." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX20673.

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Bien que la neurotransmission glutamatergique joue un rôle pivot dans le développement et l’expression de la sensibilisation comportementale aux amphétamines, le rôle spécifique de certaines structures glutamatergiques qui projettent sur l’aire tegmentale ventrale et/ou le noyau accumbens n’est pas encore bien caractérisé. Nous montrons que l’hippocampe dorsal, la partie prélimbique du cortex préfrontal et l’amygdale basolatérale joue un rôle prépondérant dans les réponses locomotrices induites par l’administration aiguë (développement de la sensibilisation) et chronique (expression de la sens

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45

Tsai, Ping-Ju, and 蔡秉儒. "Lysophosphatidic acid receptors mediate the reduction of rat brain infarct volume." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/30148483572729274704.

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碩士<br>國立中山大學<br>生物科學系研究所<br>99<br>Abstract Stroke is a potentially lethal cerebrovascular event. Many research studies devoted to the treatment of stroke. In a recent study, sphingosine-1-phosphate (S1P) has the function of reducing the brain infarct volume. However, no study has yet demonstrated that lysophosphatidic acid (LPA) has this function. LPA and S1P are thought to be the two functionally important LPLs with high structural similarity. Although the neuroprotective function of S1P in TIA rat was confirmed, the effects of LPA on the brain damage after ischemic stroke of animal remain un

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46

Jensen, Abigail M. "Cellular and molecular characterization of glutamate receptors in rat brain glia." 1992. http://catalog.hathitrust.org/api/volumes/oclc/28727758.html.

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47

Waldvogel, Henry J. "GABAA receptors in the basal ganglia of the rat, baboon and the human brain." 2000. http://hdl.handle.net/2292/3329.

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Whole document restricted, see Access Instructions file below for details of how to access the print copy.<br>The regional, cellular and subcellular distribution of GABAA receptors was investigated in the striatum and globus pallidus of the rat, baboon and human brain using receptor autoradiography, and multiple immunohistochemical labelling techniques at the light, confocal and electron microscopic levels using antibodies to the α1, α2, α3, β2,3 and γ2-subunits of the GABAA receptor complex. The results demonstrated that GABAA receptors in the striatum showed considerable subunit heterogeneit

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48

"Gonadal hormones, glutamate receptors and morphine-induced immediate early genes in the rat brain." Tulane University, 1999.

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Studies have suggested sex differences in the neural response to drugs of abuse. Previous studies have shown that morphine induces immediate early gene (IEG) expression in the brain and this is reduced by administration of the N-methyl-D-aspartate receptor antagonist, dizocilpine maleate (MK-801). This study looked at the role played by glutamate in morphine-induced IEG expression in the brain and determined if this IEG induction is sexually dimorphic. These experiments also tested if gonadal hormones modulate glutamate receptors and alter behavioral and IEG responses to morphine and MK-801 In

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49

Kirouac, Gilbert J. "An in vitro autoradiographic investigation of dopamine receptors in the brain of the spontaneously hypertensive rat." 1992. http://hdl.handle.net/1993/17507.

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50

Wu, Chun-Hung, and 吳俊宏. "Distribution of neuropeptide FF (NPFF) receptors in correlation with morphine-induced reward in the rat brain." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/70427526970631831291.

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博士<br>國防醫學院<br>生命科學研究所<br>98<br>Neuropeptide FF (NPFF) exhibited anti-/pro-opioid effects when centrally injected. It was proved to bind to its own receptors, namely NPFF1 and NPFF2 receptors, but did not bind to opioid receptors. In our previous study, we found that intra- cerebroventricularly (i.c.v.) injected NPFF suppressed morphine-induced conditioned place preference (CPP) in rats, which indicated that NPFF may play a role in the modulation of morphine-induced reward. In the present study, we further investigated the action site of NPFF to attenuate morphine-induced reward. Bilateral int

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