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Journal articles on the topic 'Rat paw edema'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Campos, Maria M., Luciana V. Mata, and João B. Callxto. "Expression of B1 kinin receptors mediating paw edema and Formalin-induced nociception. Modulation by glucocorticoids." Canadian Journal of Physiology and Pharmacology 73, no. 7 (1995): 812–19. http://dx.doi.org/10.1139/y95-110.

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Bradykinin (BK) and Tyr8-BK induced graded rat paw edema with EC50 values of 1.9 and 1.1 nmol/paw, while des-Arg9-BK (DABK, up to 300 nmol/paw) was marginally effective. Tyr8-BK, but not DABK, also caused a dose-related increase in mouse paw edema, with an EC50 of 1.3 nmol/paw. The response to Tyr8-BK (10 nmol/paw) in rat paw edema was antagonized by B2 receptor antagonists (HOE-140 or NPC 17731, 30 nmol/paw) but not by the B1 antagonist des-Arg9[Leu8]BK (DALBK, 100 nmol/paw). Daily intraplantar injections of Tyr8-BK (10 nmol/paw) for 7 days caused progressive desensitization (D) of edema in s

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2

Yanti, D. Sabella, A. W. Gunawan, and B. W. Lay. "Clitoria ternatea anthocyanin extract suppresses inflammation in carrageenaninduced rat paw edema via down-regulating genes of phosphoinositide 3-kinase signaling pathway." Food Research 4, no. 4 (2020): 1357–62. http://dx.doi.org/10.26656/fr.2017.4(4).028.

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Inflammation is characterized by an increase in vascular permeability leading to edema formation. Phosphoinositide 3-kinase (PI3K) signaling pathway plays the main role to regulate several key events in the inflammatory response to damage and infection. Our previous in silico study showed that anthocyanin and ternatin flavonoids may offer antiinflammatory potential via molecular docking model. Here, we explored whether Clitoria ternatea anthocyanin extract (CTA) had protective activity against inflammation via regulating gene expression related to PI3Ks in rat edema. CTA was extracted in metha

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Sayyed, S. Z., P. N. Nagane, and A. A. Kulkarni. "Evaluation of the Anti-Inflammatory Potential of Solanum Species Extracts in Laboratory Animals." International Journal of Research and Innovation in Applied Science X, no. VI (2025): 1683–94. https://doi.org/10.51584/ijrias.2025.100600129.

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Context: Solanum tuberosum, Solanum torvum, Solanum nigrum are used in traditional medicine for the treatment of pain and inflammation. Aims: To evaluate the anti-inflammatory potential of Solanum species. The present research work was planned to evaluate the anti-inflammatory activity of ethanolic extract of Solanum tuberosum leaves and roots, Solanum torvum leaves and roots, Solanum nigrum leaves and roots. Settings and Design: Extraction is done by Soxhlet method. Ethanolic extract was evaluated at dosage of 500mg/kg per os (by mouth) in rats. Six rats in each group were used for this study

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H. Mutlag, Shihab. "Dose Dependent Anti-inflammatory Effect of Ammi majus Alcoholic Extract in Rat: Chronic Study." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 1 (2017): 82–86. http://dx.doi.org/10.31351/vol21iss1pp82-86.

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During treatment of inflammatory diseases, many conventional therapies (non-steroidal anti-inflammatory drugs) used to relief pain and inflammation. Chronic use of the intended drugs is frequently associated with serious side effect, which may lead to discontinuation of treatment . The efficacy and dose- response effect of ammi majus extraxt (2 , 4, 8 , 16, and 32 mg/rat) were assessed using formalin to induce paw edema in rats as a model of chronic inflammation respectively. In this study, 42 rats were used and allocated into 7 groups each containing 6 rats, representing control (Distilled wa

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Zhang, Zhi-cheng, Shui-juan Zhang, Bo Jin, et al. "Ciclamilast Ameliorates Adjuvant-Induced Arthritis in a Rat Model." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/786104.

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We assessed the effect of a novel and selective phosphodiesterase 4 (PDE4) inhibitor, ciclamilast, on chronic inflammation in adjuvant-induced arthritis (AIA), a rat model of rheumatoid arthritis (RA), and acute inflammation in the rat and mouse model of carrageenan-induced paw edema and peritonitis. Our results showed that daily oral administration of ciclamilast at 1, 3, and 10 mg/kg dose-dependently inhibited the increase in hind paw volume of rats with AIA. The inhibition of paw edema was associated with inhibition of both the production of cytokines such as TNF-α, IL-1β, and IL-6 and cell

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Bunman, Sitthiphon, Sombat Muengtaweepongsa, Dilok Piyayotai, et al. "Anti-inflammatory effects of oral cannabidiol in rat models." F1000Research 12 (June 15, 2023): 680. http://dx.doi.org/10.12688/f1000research.134023.1.

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Background: Cannabidiol (CBD), a non-psychoactive compound in cannabis, has various pharmacological advantages associated with clinical use, especially for reducing inflammatory arthritis and paw edema in animal models. This study evaluated the anti-inflammatory effects of various oral CBD doses (5-40 mg/kg) in rats after injecting 0.1 mL of carrageenan. Methods: Rats were orally administered various CBD doses an hour before the carrageenan-induced inflammation to observe the anti-inflammatory effects of CBD. Paw edema was measured at 0, 1, 2, 3, 4, and 5 h after carrageenan induction. Followi

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Omoighele, Akhigbe Faith, Ckikere A. Anusiem, Samuel I. Ghasi, Ajirioghene E. Akpotu, Chidi E. Ezerioha, and Funso-Babarimisa, Funso. "Anti-Inflammatory Activity of Ethanol Leaf Extract of Arthropteris Orientalis in Wistar Albino Rat." Journal of Complementary and Alternative Medical Research 24, no. 3 (2023): 35–45. http://dx.doi.org/10.9734/jocamr/2023/v24i3502.

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The study investigated the anti-inflammatory activity of ethanol leaf extract of Arthropteris orientalis in wistar albino rat. The plant extract was obtained with the procedure as described by Khalifa et al. [1] and both acute and chronic anti-inflammatory properties was assessed. Five groups of five animals each were utilized for acute and chronic inflammation respectively. Anti-inflammatory effect of the extract was evaluated on egg albumin induced paw edema in albino rats and edema induced by formalin in the wistar albino rats’ paw for acute and chronic inflammation respectively. The extrac

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Salazar, Juan Rodrigo, Mariano Martínez-Vazquez, Carlos L. Cespedes, et al. "Anti-Inflammatory and Cytotoxic Activities of Chichipegenin, Peniocerol, and Macdougallin Isolated from Myrtillocactus geometrizans (Mart. ex Pfeiff.) Con." Zeitschrift für Naturforschung C 66, no. 1-2 (2011): 24–30. http://dx.doi.org/10.1515/znc-2011-1-204.

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The oleanane-type triterpene chichipegenin and the sterols peniocerol and macdougallin, isolated from Myrtillocactus geometrizans, showed anti-inflammatory activities in both the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema model and the carrageenan- induced rat paw edema model. All tested compounds inhibited the TPA-induced edema in a dose-dependent manner, with ED50 values less than or equal to that shown by indomethacin. Among them, peniocerol was the most active compound. However, only peniocerol and macdougallin reduced carrageenan-induced rat paw edema. On the other

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Hussein, Saba Zuhair, Kamaruddin Mohd Yusoff, Suzana Makpol та Yasmin Anum Mohd Yusof. "Gelam Honey Inhibits the Production of Proinflammatory, Mediators NO,PGE2, TNF-α, and IL-6 in Carrageenan-Induced Acute Paw Edema in Rats". Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/109636.

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Natural honey is well known for its therapeutic value and has been used in traditional medicine of different cultures throughout the world. The aim of this study was to investigate the anti-inflammatory effect of Malaysian Gelam honey in inflammation-induced rats. Paw edema was induced by a subplantar injection of 1% carrageenan into the rat right hind paw. Rats were treated with the nonsteroidal anti-inflammatory drug (NSAID) Indomethacin (10 mg/kg, p.o.) or Gelam honey at different doses (1 or 2 g/kg, p.o.). The increase in footpad thickness was considered to be edema, which was measured usi

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Wu, Xiao-Li, Chu-Wen Li, Hai-Ming Chen, et al. "Anti-Inflammatory Effect of Supercritical-Carbon Dioxide Fluid Extract from Flowers and Buds ofChrysanthemum indicumLinnén." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/413237.

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The aim of this study was to analyze the chemical composition and investigate the anti-inflammatory property of the supercritical-carbon dioxide extract from flowers and buds ofC. indicum(CISCFE). The anti-inflammatory effect was evaluated in four animal models including xylene-induced mouse ear edema, acetic acid-induced mouse vascular permeability, carrageenan-induced mouse hind paw edema, and cotton pellet-induced rat granuloma formation. The results indicated that CISCFEsignificantly attenuated xylene-induced ear edema, decreased acetic acid-induced capillary permeability, reduced carragee

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Ali, Alvira, Muhammad Mufaiduddin, Lingga Agustina, and Desy Armalina. "Noni (Morinda citrifolia L.) fruit juice reduces paw edema and protects gastric mucosal injury in rats." Journal of Advanced Biotechnology and Experimental Therapeutics 7, no. 3 (2024): 498. http://dx.doi.org/10.5455/jabet.2024.d43.

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Edema is a reliable parameter to evaluate the anti-inflammatory process. Noni (Morinda citrifolia L.) fruit has been shown to decrease inflammation. However, studies on the impact of noni juice on gastric mucosal injury are still limited. Thus, the current study aimed to assess the effect of noni fruit juice as an anti-inflammatory agent in rat paw edema and gastric mucosal injury. The rats were divided into five groups such as control, carrageenan only, carrageenan and diclofenac sodium, carrageenan and 90% noni, and carrageenan + 100% noni. Paw edema was measured, and histopathological exami

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12

Kamothi, Dhaval J., Vinay Kant, Babu Lal Jangir, Munish Ahuja, Vinay G. Joshi, and Vinod Kumar. "Thermoresponsive gel containing bilirubin nanoparticles exerts anti-inflammatory effects by inhibiting neutrophil infiltration and augmenting interleukin-10 levels in carrageenan-induced rat paw edema." Indian Journal of Pharmacology 56, no. 3 (2024): 191–97. http://dx.doi.org/10.4103/ijp.ijp_525_23.

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Abstract: BACKGROUND: Topical corticosteroids treat cutaneous inflammation but have side effects. In earlier studies, bilirubin exhibited anti-inflammatory effect, but its hydrophobicity and poor absorption limit its potential. AIM: Synthesis of bilirubin nanoparticles (BNP) and bilirubin nanoparticles gels (BNP gel) to study the anti-inflammatory effect of topical BNP gel against carrageenan-induced rat paw edema in Wistar rats. MATERIALS AND METHODS: BNP were synthesized, and BNP gels were prepared by mixing BNP of different concentrations with pluronic F-127 (PF-127). A different group for

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Amraoui, Nacer, Nozha Mayouf, Noureddine Charef, Abderrahmane Baghiani, and Lekhmici Arrar. "Antioxidant, anti-inflammatory and anti-arthritic activities of methanol extract of Tamus communis L. roots." Tropical Journal of Pharmaceutical Research 18, no. 7 (2021): 1499–506. http://dx.doi.org/10.4314/tjpr.v18i7.20.

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Purpose: To evaluate the antioxidant, anti-inflammatory and anti‐arthritic effects of the methanol extract of Tamus communis roots. Methods: The total phenolic and flavonoid contents were determined using Folin–Ciocalteu’s reagent and aluminium chloride assays, respectively while the antioxidant capacity was determined using DPPH and β-carotene/linoleate tests. For anti-inflammatory activity, carrageenan-induced paw edema in rat was used. Formaldehyde-induced paw edema and adjuvant-induced arthritis in rats were used to evaluate the anti-arthritic effect of the extract. Results: Th

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Meegada, Purna Prasad, Rama Mohan Pathapati, Sriharsha Rayam, and Raveendra Kumar Nallabothula. "Evaluation of analgesic and anti-inflammatory properties of the Allium cepa extract in rats." International Journal of Basic & Clinical Pharmacology 10, no. 7 (2021): 789. http://dx.doi.org/10.18203/2319-2003.ijbcp20212374.

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Background: The onion plant (Allium cepa) is the most widely cultivated species of the genus Allium. It has antibiotic, antidiabetic, antihypercholesterolemic, antioxidant, hemostatic, antimutagenic effects. The current study is aimed to evaluate analgesic and anti-inflammatory properties of Allium cepa extracts in rat models.Methods: In this study analgesic activity in rats is tested by Eddy’s hot plate method, tail flick method. In Eddy’s hot plate method rats are individually placed on the heated plate of the analgesic meter maintained at 550C and mean reaction time was calculated at regula

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15

Ha La Tu, Hu Bi Si, Khaliunaa Tumurbaatar, Chimedragchaa Chimedtseren, Tsend-Ayush Damba, Tsogt Bukhbayar, and Tsend-Ayush Damba. "Effect of Panzeria Alaschanica Kupr. on Carrageenan-Induced Acute Inflammation in Rats." Central Asian Journal of Medical Sciences 9, no. 3 (2023): 140–46. http://dx.doi.org/10.24079/cajms.2023.09.005.

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Objectives: In the present study, we aimed to investigate the effect of Panzeria alaschanica Kupr. (P. alaschanica) on carrageenan-induced acute inflammation in rats. Method: Carrageenan-induced rat paw edema was used to evaluate the anti-inflammatory activity. P. alaschanica extract (32, 64, and 160 mg/kg/ BW) or vehicle was given orally 60 minutes before the subplantar injection of carrageenan. Ibuprofen (100 mg/kg) was used as a standard drug. The carrageenan-injected paw was measured 30, 60, 120, 180, and 240 minutes after the carrageenan injection. The levels of serum tumor necrosis facto

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Alghaithy, AA, HA El-Beshbishy, AB AbdelNaim, AA Nagy, and EM Abdel-Sattar. "Anti-inflammatory effects of the chloroform extract of Pulicaria guestii ameliorated the neutrophil infiltration and nitric oxide generation in rats." Toxicology and Industrial Health 27, no. 10 (2011): 899–910. http://dx.doi.org/10.1177/0748233711399320.

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Pulicaria guestii Rech.f. & Rawi is a fragrant, perennial herb, which grows wild, west of Al-Madinah, Saudi Arabia. Several reports were published on the anti-inflammatory activity of the sesquiterpene lactones, phenolics and flavonoids, which constitute the main active constituents of the members of the genus Pulicaria. The present study was designed to explore the potential anti-inflammatory effect of P. guestii in several experimental models. The methanol extract of the dried aerial parts of P. guestii was extracted with petroleum ether, chloroform and n-butanol. The chloroform extract

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Talluri, Mallikarjuna Rao, Battu Ganga Rao, and Y. Venkateswaea Rao. "Anti-Inflammatory Activity of Chrozophora rottleri Extracts on Carrageenan-Induced Rat Paw Edema." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 3 (June 2016): 20–26. http://dx.doi.org/10.18052/www.scipress.com/ijppe.3.20.

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The present study was intended to evaluate Anti-inflammatory activity ofC. rottleriextracts (Hydroalcoholic, Methanol, Ethyl acetate and Hexane). The Anti-inflammatory activity ofC.rottleriextracts at doses of 125mg/kg, 250mg/kg and 500mg/kg using carrageenan induced rat paw edema model compared with standard drug (Indomethacin). The selected plant extracts significantly inhibited paw edema along with the standard drug Indomethacin. Of all extracts, methanol extract produced significant effect on reduction of increased paw thickness, hydro alcoholic and ethyl acetate extracts produced moderate

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Abdallah, Marwa H., Hanaa A. Elghamry, Nasrin E. Khalifa, et al. "Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity." Gels 8, no. 11 (2022): 737. http://dx.doi.org/10.3390/gels8110737.

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Ginger, a natural plant belonging to the Zingeberaceae family, has been reported to have reasonable anti-inflammatory effects. The current study aimed to examine ginger extract transdermal delivery by generating niosomal vesicles as a promising nano-carrier incorporated into emulgel prepared with sesame oil. Particle size, viscosity, in vitro release, and ex vivo drug penetration experiments were performed on the produced formulations (ginger extract loaded gel, ginger extract loaded emulgel, ginger extract niosomal gel, and ginger extract niosomal emulgel). Carrageenan-induced edema in rat hi

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Ishikawa, Masaaki, Masayasu Ozaki, Yoshio Takayanagi, and Kenichi Sasaki. "Rat paw edema induced by Wheat germ lectin." Japanese Journal of Pharmacology 64 (1994): 313. http://dx.doi.org/10.1016/s0021-5198(19)50887-3.

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Cirino, G., C. Cicala, M. R. Bucci, L. Sorrentino, J. M. Maraganore, and S. R. Stone. "Thrombin functions as an inflammatory mediator through activation of its receptor." Journal of Experimental Medicine 183, no. 3 (1996): 821–27. http://dx.doi.org/10.1084/jem.183.3.821.

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A rat model of inflammation was used to investigate the biological effects of thrombin. The thrombin-specific inhibitor Hirulog markedly attentuated the carrageenin-induced edema of the paw of the rat. Injection of thrombin into the paw also produced edema. The effect of thrombin was due to activation of its receptor; a thrombin receptor activating peptide (TRAP) reproduced the effects of thrombin in causing edema. TRAP also increased vascular permeability as demonstrated by extravasation of Evans blue and 125I-labeled serum albumin. The release of bioactive amines played an important role in

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Amala, Jeyakumar J. 1. *. Karuppusamy S. 1. and Pannerselvam N. 2. "PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATIONS ON THE MACRO MARINE ALGAE SARGASSUM TENERRIMUM J. AGARDH." Journal of Pharma Research 8, no. 8 (2019): 530–34. https://doi.org/10.5281/zenodo.3374073.

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<strong><em>ABSTRACT</em></strong> <strong><em>S</em></strong><em>argassum tenerrimum J. Agardh, a macro marine alga collected from the Mandapam, Gulf of Mannar region and was extracted with non-polar chloroform solvent. The crude extract of the same was subjected to study the preliminary phytochemical investigation. It indicates the presence of carbohydrates and alkaloids. GC-MS analysis of the extract showed 12 peaks among them N- hexadecanoic acid (36.4%) and Oleic acid (12%) represented high volume. Carrageenan induced paw edema model in Wistar rat showed the significant reduction of edema

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R. K. Gupta, M. Lohani, and R. Vishwakarma. "Inhibition of Formalin Induced Paw Edema in Rats by Various Fractions/Extracts of Bryophyllum pinnatum." Journal of Pharmaceutical Technology, Research and Management 7, no. 2 (2019): 63–66. http://dx.doi.org/10.15415/jptrm.2019.72008.

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Traditionally, Bryophyllum pinnatum is used in the management of arthritis and inflammatory diseases. However, B. pinnatum has not been analysed previously for anti-inflammatory activity. Hence, this study is designed to determine the anti-inflammatory effects of various fractions of B. pinnatum leaf extract using rat model of formalin-induced paw edema. Treatment with various fractions showed marked decrease in formalin-induced paw volume and edema in rats. The results of BPAAF treatment were comparable to standard drug, diclofenac. These results indicate that B. pinnatum could be developed a

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Lin, Chun-Ching, and Den-En Shieh. "The Anti-inflammatory Activity of Scutellaria rivularis Extracts and Its Active Components, Baicalin, Baicalein and Wogonin." American Journal of Chinese Medicine 24, no. 01 (1996): 31–36. http://dx.doi.org/10.1142/s0192415x96000050.

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Five extracts (n-hexane, chloroform, ethyl acetate, n-butanol and water) of Scutellaria rivularis Benth. were evaluated for their anti-inflammatory activity against carrageenan-induced paw edema in rats and compared with indomethacin. The result indicated that chloroform extract proved to be the most effective in all of the extracts. Consequently, three major components (baicalin, baicalein and wogonin) of the chloroform extract were further tested for their anti-inflammatory activity using the same model. It was found that baicalin exhibits the greatest inhibition activity against carrageenan

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MRUTYUNJAY, M. MIRJE, KUMBAR SHIVAPRASAD, and MOHARIR GURUDATTA. "Anti-Inflammatory Activity of Ocimum Sanctum (Linn) In Formalin Induced Acute Models of Albino Rats." International Journal of Clinical and Biomedical Research 1, no. 1 (2015): 1–4. https://doi.org/10.5281/zenodo.2532105.

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The inflammatory process is the response to an injurious stimulus. It can be evoked by a wide variety of noxious agents (e.g., infections, antibodies, physical injuries). Many nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone, indomethacin etc. are in clinical use but all these are not completely devoid of adverse effects<sup>2</sup>.In this study, the anti-inflammatory activity of O. sanctum alone and in combination with indomethacin was studied using formalin-induced rat paw edema. Aqueous extract of O. sanctum (200mg/kg, 300mg/kg  or 400mg/kg) was administered

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Mohammad, Ashraf, Kumar Basedia Deepak, and Dubey B.K. "Study of Synergistic Anti-inflammatory Action of Murraya Koenigii and Mangifera Indica Leaf Extracts." American Journal Of Pharmacy And Health Research 10, no. 6 (2022): 1–12. https://doi.org/10.5281/zenodo.7098978.

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ABSTRACT The objective of the present study was to assess the anti-inflammatory potential of combined extracts of <em>Murraya koenigii</em> and <em>Mangifera indica</em>using the carrageenan induced rat paw edema method. The extraction yield in methanol was found to be 26.8 % for <em>Murraya koenigii</em> and 31.6 % for <em>Mangifera indica.</em> The findings of preliminary phytochemical analysis suggest the presence of alkaloids, saponin glycosides, phenolics, terpenoids, and flavonoids in the leaf of the <em>Murraya koenigii</em> while alkaloids and glycosides were not found to be present in

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Silva, P. M. R., R. S. B. Cordeiro, M. A. Martins, M. G. M. O. Henriques, and B. B. Vargaftig. "Platelet involvement in rat paw edema induced by 2-methoxy-PAF." Inflammation 10, no. 4 (1986): 393–401. http://dx.doi.org/10.1007/bf00915823.

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Varshosaz, Jaleh, Valiollah Hajhashemi, and Sindokht Soltanzadeh. "Lipid Nanocapsule-Based Gels for Enhancement of Transdermal Delivery of Ketorolac Tromethamine." Journal of Drug Delivery 2011 (November 17, 2011): 1–7. http://dx.doi.org/10.1155/2011/571272.

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Previous reports show ineffective transdermal delivery of ketorolac by nanostructured lipid carriers (NLCs). The aim of the present work was enhancement of transdermal delivery of ketorolac by another colloidal carriers, lipid nanocapsules (LNCs). LNCs were prepared by emulsification with phase transition method and mixed in a Carbomer 934P gel base with oleic acid or propylene glycol as penetration enhancers. Permeation studies were performed by Franz diffusion cell using excised rat abdominal skin. Aerosil-induced rat paw edema model was used to investigate the in vivo performance. LNCs cont

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Maxia, Andrea, Cinzia Sanna, Maria Assunta Frau, Alessandra Piras, Manvendra Singh Karchuli та Veena Kasture. "Anti-inflammatory Activity of Pistacia lentiscus Essential Oil: Involvement of IL-6 and TNF-α". Natural Product Communications 6, № 10 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601033.

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The topical anti-inflammatory activity of essential oil of Pistacia lentiscus L. was studied using carrageenan induced rat paw edema and cotton pellet induced granuloma. The effect on serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats inserted with cotton pellet was also investigated. On topical application, the oil exhibited a significant decrease in paw edema. The oil also inhibited cotton pellet-induced granuloma, and reduced serum TNF-α and IL-6. It can be concluded that the essential oil of Pistacia lentiscus reduces leukocyte migration to the damaged tissue and exhibi

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Haleagrahara, Nagaraja, Mirashini Swaminathan, Srikumar Chakravarthi та Ammu Radhakrishnan. "Therapeutic Efficacy of Vitamin Eδ-Tocotrienol in Collagen-Induced Rat Model of Arthritis". BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/539540.

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Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease primarily involving inflammation of the joints. Although the management of the disease has advanced significantly in the past three decades, there is still no cure for RA. The aim of this study was to determine the therapeutic efficacy ofδ-tocotrienol, in the rat model of collagen-induced arthritis (CIA). Arthritis was induced by intradermal injection of collagen type II emulsified in complete Freund’s adjuvant. CIA rats were orally treated withδ-tocotrienol (10 mg/kg) or glucosamine hydrochloride (300 mg/kg) from day 25 to

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K., RAVISHANKAR, GNANESWARI K., and THIRUMALA DEVI S. "Evaluation of analgesic and anti-inflammatory activities of ethanolic fruit extract of Terminalia chebula." GSC Advanced Research and Reviews 18, no. 2 (2024): 160–66. https://doi.org/10.5281/zenodo.11216232.

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Analgesic and Anti-inflammatory activities of ethanolic fruit extract of <em>Terminalia chebula </em>was evaluated using tail-flick method, eddy’s hot plate method, acetic acid induced writhing responses and <em>in-vivo</em> anti-inflammatory property was determined using carrageenan rat paw edema. The ethanolic fruit extract of <em>Terminalia chebula </em>at different concentrations significantly inhibited the nociception in comparision with different standard drugs that showed anti-nociception. The test extract also reduced the edema induced in rats using

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Ksheerasagar, Vinay, Venkatanarayana Narapogu, Princ Bgheal, and Nagesh Chaganti. "Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema." National Journal of Physiology, Pharmacy and Pharmacology 13, no. 9 (2023): 1. http://dx.doi.org/10.5455/njppp.2023.13.01003202323012023.

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Background: Inflammation is described as a localized physical condition whereat part of the body becomes swollen, reddened, hot, and consistently painful, largely as a response to injury or infection. Aim and Objectives: The current study is designed to study the Abutilon indicum for its anti-inflammatory activity in albino rats-induced paw edema by carrageenan. Materials and Methods: Randomly 30 albino rats from both sexes were taken and divided into five groups, six in each. Normal saline 25 mL/kg (control), diclofenac 9 mg/kg (standard), and three different doses of plant extract (EEAI) suc

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Burayk, Shady, Kentaro Oh-hashi, and Mahmoud Kandeel. "Drug Discovery of New Anti-Inflammatory Compounds by Targeting Cyclooxygenases." Pharmaceuticals 15, no. 3 (2022): 282. http://dx.doi.org/10.3390/ph15030282.

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The goal of achieving anti-inflammatory efficacy with the fewest possible adverse effects through selective COX-2 inhibition is still being investigated in order to develop drugs with safe profiles. This work shows the efficacy and safety profile of two novel benzimidazole piperidine and phenoxy pyridine derivatives in reaching this goal, which would be considered a major achievement in inflammatory therapy. The compounds were evaluated by virtual screening campaign, in vitro cyclooxygenase 1 and 2 (COX-1 and COX-2) inhibition, in vivo carrageenan-induced rat paw edema assay, cytotoxicity agai

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Subramaniyan, Vetriselvan, and Velmurugan Paramasivam. "POTENTIAL ANTI-INFLAMMATORY ACTIVITY OF PLUMBAGO ZEYLANICA." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 372. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.20357.

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Objective: To determine the anti-inflammatory activity of dichloromethane extract of Plumbago zeylanica (DMEPZ), and its possible mechanism of action.Methods: Male Wistar rats (180-200 g) under controlled standard conditions (24±1°C, 55-58 humidity and 12 hrs light/dark cycle). The groups were divided into 5 groups (n=6/group) and assigned as positive control, negative control, and standard and two different test dose groups of P. zeylanica. Paw edema induced by subplantar injection of 0.1 mL of carrageenan (suspended in 1% carboxymethyl cellulose) into the right hind paw in all groups except

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Darmaputra, I. Gusti Nyoman, I. Gusti Ayu Sattwika Pramita, and Ketut Kwartantaya Winaya. "Application of Moringa Oleifera leaves extract cream inhibits paw edema in white male Wistar rat (Rattus norvegicus) induced by carrageenan 1%." Bali Medical Journal 11, no. 1 (2022): 122–26. http://dx.doi.org/10.15562/bmj.v11i1.3384.

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Introduction: Inflammation is the body's response to body tissue injury characterized by swelling or edema. Moringa oleifera is known to have many benefits as herbal medicine. Moringa oleifera leaves have been shown to have anti-inflammatory activity. The polyphenol content in Moringa leaves, such as flavonoids and tannins, has been observed as a potential anti-inflammatory.Methods: Thirty white male Wistar rats were randomly divided into five groups. Group 0 (negative control group) was given base cream, group 1 (positive control) was given 2.5% hydrocortisone cream, group 2 was given 10% mor

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Paniagua-Pérez, Rogelio, Laura Sánchez-Chapul, Eduardo Madrigal-Bujaidar, et al. "Anti-Inflammatory Potential of Pteropodine in Rodents." Metabolites 13, no. 8 (2023): 907. http://dx.doi.org/10.3390/metabo13080907.

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Pteropodine (PT) is a component of some plants with potentially useful pharmacological activities for humans. This compound has biomedical properties related to the modulation of the immune system, nervous system, and inflammatory processes. This study addresses the anti-inflammatory and antioxidant capacity of pteropodin in a murine model of arthritis and induced edema of the mouse ear. To evaluate the anti-inflammatory activity, we used the reversed passive Arthus reaction (RPAR), which includes the rat paw edema test, the rat pleurisy test, and a mouse ear edema model. The antioxidant effec

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Novikov, Vasiliy Egorovich, Elena Vasil'yevna Pozhilova, and Sergey Alekseevich Ilyukhin. "Influence of antihypoxants on the development of acute phormalin-induced edema." Reviews on Clinical Pharmacology and Drug Therapy 13, no. 1 (2015): 41–44. http://dx.doi.org/10.17816/rcf13141-44.

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In the experiment in a model of acute formalin-induced inflammation of rat paw, the changes of size of the affected limbs (paw edema) and parameters of leukogram were registered. The anti-inflammatory effect of antihypoxants (amtizol, hesperidin, hypoxen, metaprot) was investigated. It has been shown that hypoxen 50 mg/kg have weak anti-inflammatory activity, but potentiate the effect of nonsteroid anti-inflammatory drugs. At simultaneous enteral administration of hypoxen with acetylsalicylic acid or diclofenac, evident anti-inflammatory effect was marked, that was manifested by significant re

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Cole, Harlan W., Charles E. Brown, David E. Magee, Christopher Magee, Roger E. Roudebush, and Henry U. Bryant. "Serotonin-induced paw edema in the rat: Pharmacological profile." General Pharmacology: The Vascular System 26, no. 2 (1995): 431–36. http://dx.doi.org/10.1016/0306-3623(94)00180-u.

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DiMartino, M. J., G. K. Campbell, C. E. Wolff, and N. Hanna. "The pharmacology of arachidonic acid-induced rat paw edema." Agents and Actions 21, no. 3-4 (1987): 303–5. http://dx.doi.org/10.1007/bf01966498.

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Yuniati, Renni, and Bambang Sulardiono. "Effectivity of Holothuria scabra and Spirulina platensis extract combination as an Antiinflammatory Agent Measured by Carrageenan-induced Rat Paw Edema." ILMU KELAUTAN: Indonesian Journal of Marine Sciences 25, no. 3 (2020): 103–9. http://dx.doi.org/10.14710/ik.ijms.25.3.103-109.

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Sea cucumber, Holothuria scabra, can be found abundantly in Indonesian seas, which is also known to possess several medicinal properties. Spirulina platensis is another marine resources that has recently been extensively researched for its medicinal ability, such as anti-inflammatory effect. This study aims to evaluate the efficacy of H. scabra extract combined with S. platensis extract in reducing inflammation. This study uses male Wistar rats as the study animal. Inflammation was induced by injecting carrageenan solution into the mice paw. Combination of H. scabra and S. platensis extract wi

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A. Sulaiman, Amaal, Saad A. Hussain, Kasim M. Jum'ma, and Assad H. Sigar. "Evaluation of the Anti-Inflammatory Effect of Pioglitazone in Experimental Models of Inflammation in Rats." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, Suppl. (2017): 1–6. http://dx.doi.org/10.31351/vol18isssuppl.pp1-6.

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The antidiabetic thiozolidinediones (TZDs) a class of peroxisome proliferators-activated receptor (PPAR) ligands has recently been the focus of much interest for their possible role in regulation of inflammatory response. The present study was designed to evaluate the anti-inflammatory activity of pioglitazone in experimental models of inflammation in rats. The present study was conducted to evaluate the anti inflammatory effect of TZDs (pioglitazone 3mg/Kg) on acute, sub acute and chronic model of inflammation by using egg-albumin and formalinâ€“induced paw edema in 72 rats, relative to refer

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Adhikari, Anjan, Aioshi Saha, Rania Indu, Tapas Kumar Sur, and Anup Kumar Das. "Evaluation of anti-inflammatory effect of beetroot extract in animal models." International Journal of Basic & Clinical Pharmacology 6, no. 12 (2017): 2853. http://dx.doi.org/10.18203/2319-2003.ijbcp20175207.

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Background: Inflammation is complex biological response of body tissues to foreign particles or pathogens. However, adverse effects of anti-inflammatory drugs, necessitate the search for a novel compound from herbal origin. Beta vulgaris rubra or red beetroot, a vegetable plant, is known to possess various beneficial effects. Present study aimed to evaluate the anti inflammatory effect of beet roots in animal models.Methods: Carrageenan-induced and Complete Freund’s adjuvant-induced rat paw edema model were used to assess the acute and chronic anti- inflammatory potential of the Beetroot as co

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Shejawal, N., S. Menon, and S. Shailajan. "A simple, sensitive and accurate method for rat paw volume measurement and its expediency in preclinical animal studies." Human & Experimental Toxicology 33, no. 2 (2013): 123–29. http://dx.doi.org/10.1177/0960327113482594.

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Several methods are used to evaluate the inflammatory changes. Measurement of edema is the most commonly used method for evaluating artificially induced inflammation in rat model. In this context, we present a method for the measurement of volume of rat paw, in which two glass columns containing fluid are connected by a glass tube. Paw is immersed in one column and the other column is placed on weighing balance. Upon immersion of paw, equal volume of fluid displaced applies a force F, which shows specific and proportional increment in the level of fluid in both the columns, which could then be

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Miao, Ming San, Bo Lin Cheng, Yuan Peng Chen, and Na Jiang. "The Anti-Inflammatory Effects of Leptochloa Paste for External Use." Applied Mechanics and Materials 664 (October 2014): 388–91. http://dx.doi.org/10.4028/www.scientific.net/amm.664.388.

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Objective: To study the effect of leptochloa on rats and mice ear swelling model. Methods: Each experiment group, mice were given corresponding drugs, according to the experiment requirement to give the corresponding dose, before the end of the experiment, the experimental model were given xylene,egg manufacture to corresponding experimental models, the determination of the experimental index.Results: Compared with the saline group, each dose Leptochloa paste group can significantly reduce the mice ear swelling; can obviously reduce the rat paw swelling. Are large doses Leptochloa paste have b

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Dholakia, Sandip P. "Synthesis and anti-inflammatory activity of 2-amino-4,5-diphenyl-1-(substituted)-1H-pyrrole-3- carbonitrile derivatives." Journal of medical pharmaceutical and allied sciences 12, no. 1 (2023): 5613–17. http://dx.doi.org/10.55522/jmpas.v12i1.4452.

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Pyrrole is privileged and active heterocycle with diverse pharmacological activities that specifically serve as a promising scaffold for antiinflammatory, antimalarial, antimicrobial, antiviral, antitubercular, and enzyme-inhibiting drugs. In an attempt to explore this scaffold, a series of 2- amino-4,5-diphenyl-1-(substituted)-1H-pyrrole-3-carbonitrilewere synthesized and screened for anti-inflammatory activity. The structures of synthesized novel compounds were characterized by 1H Nuclear Magnetic Resonance, Mass and Fourier Transfer Infrared spectroscopic data. All the compounds are screene

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Rajalakshmi, K., and V. R. Mohan. "Antiinflammatory Activity of Stem and Leaf of Myxopyrum serratulum A.W. Hill (Oleaceae)." International Journal of Current Pharmaceutical Review and Research 7, no. 4 (2016): 190–92. https://doi.org/10.5281/zenodo.12680829.

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In the present study antiinflammatory activity of ethanol extracts of stem and leaf of Myxopyrum serratulum wereevaluated by carrageenan induced rat paw edema model in rats. Preliminary phytochemical analysis of ethanol extracts ofstem and leaf showed the presence of alkaloid, catechin, coumarin, flavonoid, tannin, saponin, steroid, phenol, glycoside,terpenoid and xanthoprotein. Maximum inhibition (86.09%) was obtained at the dose of 400 mg kg-1 of M. serratulumstem after 3 hours of drug treatment in carrageenan induced paw edema, whereas, indomethocin produced 85.37% ofinhibition. The present

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Ardizzone, Alessio, Roberta Fusco, Giovanna Casili, et al. "Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain." International Journal of Molecular Sciences 22, no. 4 (2021): 1967. http://dx.doi.org/10.3390/ijms22041967.

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Palmitoylethanolamide (PEA), a fatty acid amide, has been widely investigated for its analgesic and anti-inflammatory properties. The ultra-micronized formulation of PEA (um-PEA), that has an enhanced rate of dissolution, is extensively used. Acetyl-l-carnitine (LAC), employed for the treatment of neuropathic pain in humans, is able to cause analgesia by up-regulating type-2 metabotropic glutamate (mGlu2) receptors. In the present study, we tested different associations of um-PEA, LAC and non-micronized PEA (non-m-PEA) in a rat model of carrageenan (CAR)-induced paw edema. Intraplantar injecti

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Waghulde, Sandeep, Sweety Bhopi, Trunali Ghude, Roshani Gotarane, and Mohan Kale. "Comparative Anti-Inflammatory Activity of Aril Extracts of Punica granatum Fruits." Proceedings 9, no. 1 (2018): 66. http://dx.doi.org/10.3390/ecsoc-22-05783.

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A substanceor treatment with an anti-inflammatory propertyis one that reduces inflammation or swelling. The main objective of this study is to evaluate the anti-inflammatory activity of pomegranate aril extract on rat paw. The anti-inflammatory activity of pomegranate was tested on rats by employing the induced carrageenan rat paw edema method. Various concentrations of the arils and the aril mixture (1:1) were prepared by dissolving in hydroalcohol and alcohol to obtain final concentrations of 100 mg/kg, 200 mg/kg, and 400 mg/kg to betested against the organisms. The effectivity of granatin B

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Aditama, Agnis Pondinekaria. "AKTIVITAS ANTIINFLAMASI FRAKSI ETANOL DAUN GEDI (Abelmoschus manihot L. Medik) PADA TIKUS PUTIH GALUR WISTAR." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2, no. 2 (2021): 63–68. http://dx.doi.org/10.53864/jifakfar.v2i2.30.

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Gedi leaves (Abelmoschus manihot L. Medik) has been used empirically by the people of North Sulawesi to cure the disease. Flavonoids and steroids in Gedi leaves suspected to have anti-inflammatory effects. This Study aims to examine the anti-inflammatory effects of ethanol fraction from Gedi leaves (Abelmoschus manihot L. Medik) on edema of white males wistar foot induced with 1 % caragen, and to determine an effective dose of fraction to decrease the edema volume of Rat foot. The test was done using Rat Hind Paw Edeme or esthablished an artificial inflammation in left foot of white male rats.

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Ben Khedir, Sameh, Masarra Mzid, Sana Bardaa, Dorsaf Moalla, Zouheir Sahnoun, and Tarek Rebai. "In Vivo Evaluation of the Anti-Inflammatory Effect ofPistacia lentiscusFruit Oil and Its Effects on Oxidative Stress." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/6108203.

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In order to find new topical anti-inflammatory agents, we had recourse to a medicinal plant. This work was designed to determine the topical anti-inflammatory effect ofPistacia lentiscusfruit oil (PLFO), using carrageenan-induced paw edema rat model, and to evaluate its effects on oxidative stress. The topical anti-inflammatory activity of PLFO was compared to Inflocine® and estimated by measuring the diameter of paw edema, for 5 hours at a 1-hour interval. After that the rats were scarified and the inflamed paw tissue was removed for the exploration of some parameters of oxidative stress and

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Ahmed Yas, Ali. "Formulation and Evaluation of Diclofenac Sodium as a Topical Preparation." Tikrit Journal of Pharmaceutical Sciences 2, no. 2 (2023): 122–31. http://dx.doi.org/10.25130/tjphs.2006.2.8.122.131.

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The aim of this study was to evaluate and compare the in vitro and in vivo transdermal potential ofw/o microemulsion (M) and gel (G) bases for diclofenac sodium (DS). The effect of dimethylsulfoxide (DMSO) as a penetration enhancer was also examined when it was added to the Mformulation. To study the in vitro potential of these formulations, permeation studies wereperformed with Franz diffusion cells using excised dorsal rat skin. To investigate their in vivoperfoniranc e, a car-rageenan - induced rat paw edema model was used. The commercial formulationof DS (C) was used as a reference formula

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