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Journal articles on the topic 'Rathke cleft cyst'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Naylor, M. F., B. W. Scheithauer, G. S. Forbes, F. H. Tomlinson, and W. F. Young. "Rathke Cleft Cyst." Journal of Computer Assisted Tomography 19, no. 6 (1995): 853–59. http://dx.doi.org/10.1097/00004728-199511000-00003.

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2

Ogawa, Yoshikazu, and Teiji Tominaga. "A partially ossified solid and cystic Rathke cleft cyst." Journal of Neurosurgery 112, no. 6 (2010): 1324–26. http://dx.doi.org/10.3171/2009.10.jns09826.

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A Rathke cleft cyst is considered to arise from the remnants of the Rathke pouch, and it consists of single cuboidal or columnar epithelium including cilia and goblet cells, which secrete mucus into the cyst. Magnetic resonance imaging characteristically shows a thin membranous cystic wall that enhances with Gd, and homogeneous intensity of the content suggesting fluid collection. Cases with an irregularly thickened and/or calcified cyst wall, presumably due to chronic inflammation of the wall, are rare. A 21-year-old woman presented with an extremely rare case of a solid and cystic Rathke cle

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3

Maggio, W. W., W. S. Cail, J. R. Brookeman, J. A. Persing, and J. A. Jane. "Rathke??s cleft cyst." Neurosurgery 21, no. 1 (1987): 60???2. http://dx.doi.org/10.1097/00006123-198707000-00011.

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4

Zhong, Weiying, Chao You, Shu Jiang, et al. "Symptomatic Rathke cleft cyst." Journal of Clinical Neuroscience 19, no. 4 (2012): 501–8. http://dx.doi.org/10.1016/j.jocn.2011.07.022.

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5

Xin, Wei, Mark A. Rubin, and Paul E. McKeever. "Differential Expression of Cytokeratins 8 and 20 Distinguishes Craniopharyngioma From Rathke Cleft Cyst." Archives of Pathology & Laboratory Medicine 126, no. 10 (2002): 1174–78. http://dx.doi.org/10.5858/2002-126-1174-deocad.

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Abstract Background.—Craniopharyngiomas are epithelial neoplasms usually located in the sellar and suprasellar regions. Distinguishing craniopharyngioma from Rathke cleft cyst is sometimes difficult, and the distinction is clinically significant because Rathke cleft cysts have a better prognosis than craniopharyngiomas. Design.—We retrieved 10 cases with a primary diagnosis of craniopharyngioma and 5 cases with a diagnosis of Rathke cleft cyst for analysis. Five cases of normal pars intermedia of pituitary glands from autopsy served as controls. We evaluated the expression patterns of a broad

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6

Sivakumar, Walavan, Chad D. Cole, and William T. Couldwell. "Rathke cleft cyst presenting with hyponatremia: an unusual presentation." Neurosurgical Focus 31, no. 1 (2011): E4. http://dx.doi.org/10.3171/2011.4.focus1180.

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The authors report a case of Rathke cleft cyst presenting with severe hyponatremia. A 33-year-old man suffered sudden severe headaches, visual changes, dizziness, nausea, vomiting, and a metallic taste in his mouth. Initial laboratory values demonstrated severe hyponatremia. Magnetic resonance imaging revealed a cystic lesion with questionable intracystic hemorrhage, concerning for pituitary apoplexy. Transsphenoidal decompression and drainage of the cyst confirmed the diagnosis of Rathke cleft cyst and resolved the symptoms. Postoperative follow-up studies at 6 months demonstrated normal endo

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7

Hsu, Hugo Y., Alfio Piva, and Alfredo A. Sadun. "Devastating complications from alcohol cauterization of recurrent Rathke cleft cyst." Journal of Neurosurgery 100, no. 6 (2004): 1087–90. http://dx.doi.org/10.3171/jns.2004.100.6.1087.

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✓ Rathke cleft cysts are commonly found on autopsy but are seldom symptomatic. Conventional treatment of these lesions consists of transsphenoidal drainage with partial excision of the cyst, and recurrence is rare. Alternatively, the instillation of absolute alcohol into the cyst has been described in several reports, with no complications. The authors report on a woman with Rathke cleft cyst that recurred three times after the initial treatment; the lesion was treated with alcohol cauterization on the final recurrence with devastating complications. This 51-year-old woman presented in 1992 wi

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8

Han, Dong Bok, Ho Kyu Lee, Chang Jin Kim, et al. "MRI Findings of Rathke Cleft Cyst." Journal of the Korean Radiological Society 37, no. 6 (1997): 985. http://dx.doi.org/10.3348/jkrs.1997.37.6.985.

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9

Asari, Shoji, Takahiko Ito, Shohei Tsuchida, and Takumi Tsutsui. "MR Appearance and Cyst Content of Rathke Cleft Cysts." Journal of Computer Assisted Tomography 14, no. 4 (1990): 532–35. http://dx.doi.org/10.1097/00004728-199007000-00006.

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10

Salle, Laurence, Marie-Pierre Teissier-Clément, Robin Mas, Marie-Paule Boncoeur-Martel, and Henri Salle. "Spontaneous involution of a Rathke cleft cyst." Annales d'Endocrinologie 82, no. 6 (2021): 626–28. http://dx.doi.org/10.1016/j.ando.2021.10.001.

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11

Woernle, Christoph, Henning Leske, Diane Möller-Goede, et al. "Ruptured Rathke Cleft Cyst Mimicking Pituitary Apoplexy." Journal of Neurological Surgery Part A: Central European Neurosurgery 74, S 01 (2013): e229-e232. http://dx.doi.org/10.1055/s-0033-1343985.

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12

Yang, Chengxian, Xinjie Bao, Xiaohai Liu, et al. "Rathke cleft cyst masquerading as pituitary abscess." Medicine 96, no. 10 (2017): e6303. http://dx.doi.org/10.1097/md.0000000000006303.

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13

Cheng, Lei, Pin Guo, Peng Jin, Huanting Li, Mingchao Fan, and Enyuan Cai. "Spontaneous Involution of a Rathke Cleft Cyst." Journal of Craniofacial Surgery 27, no. 8 (2016): e791-e793. http://dx.doi.org/10.1097/scs.0000000000003132.

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14

Kasperbauer, Jan L., Laura J. Orvidas, John L. D. Atkinson, and Charles F. Abboud. "Rathke Cleft Cyst: Diagnostic and Therapeutic Considerations." Laryngoscope 112, no. 10 (2002): 1836–39. http://dx.doi.org/10.1097/00005537-200210000-00024.

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15

Benveniste, Ronald J., Wesley A. King, Jane Walsh, Jacob S. Lee, Thomas P. Naidich, and Kalmon D. Post. "Surgery for Rathke cleft cysts: technical considerations and outcomes." Journal of Neurosurgery 101, no. 4 (2004): 577–84. http://dx.doi.org/10.3171/jns.2004.101.4.0577.

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Object. The aim of this study was to identify the optimal surgical goals and techniques for managing symptomatic Rathke cleft cysts (RCCs). Methods. The authors conducted a retrospective study of 62 consecutive patients who had undergone surgery for RCCs. Postoperative follow up was a mean of 28 months. Fifty-six patients underwent transsphenoidal cyst decompression and biopsy procedures, and six underwent cyst wall resection. Postoperatively, symptoms improved in 91% of patients with headaches and 92% of patients with visual deficits. Decompression and biopsy were associated with a 10% incide

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16

Aho, Christopher J., Charles Liu, Vladimir Zelman, William T. Couldwell, and Martin H. Weiss. "Surgical outcomes in 118 patients with Rathke cleft cysts." Journal of Neurosurgery 102, no. 2 (2005): 189–93. http://dx.doi.org/10.3171/jns.2005.102.2.0189.

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Object. Microscopic Rathke cleft cysts are a common incidental autopsy finding, but some Rathke cleft cysts can become sufficiently large to cause visual impairment, hypothalamic—pituitary dysfunction, and headaches. In this study patients were evaluated pre- and postoperatively to ascertain the clinical significance of surgical intervention on endocrine and visual improvement. Factors correlated with cyst recurrence were also evaluated. Methods. A retrospective analysis was conducted in 160 patients with Rathke cleft cysts who were treated between 1984 and 1995 and completed at least a 5-year

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17

Hayashi, Yutaka, Osamu Tachibana, Naoki Muramatsu, et al. "Rathke Cleft Cyst: MR and Biomedical Analysis of Cyst Content." Journal of Computer Assisted Tomography 23, no. 1 (1999): 34–38. http://dx.doi.org/10.1097/00004728-199901000-00008.

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18

Vijayasaradhi, Mudumba, VangalaBramha Prasad, MeghaS Uppin, and Challa Sundaram. "Ossified rathke′s cleft cyst: A rare variant." Neurology India 60, no. 5 (2012): 534. http://dx.doi.org/10.4103/0028-3886.103214.

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19

TANAKA, Tomoko, Hidehiro OKA, Nobuyuki KAWANO, Ikuo KOBAYASHI, Hirotada SAEGUSA, and Kiyotaka FUJII. "Juvenile Symptomatic Rathke''s Cleft Cyst —Case Report—." Neurologia medico-chirurgica 38, no. 9 (1998): 578–81. http://dx.doi.org/10.2176/nmc.38.578.

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20

Elarjani, Turki, Meshari Rashed Alhuthayl, Mahammad Dababo, and Imad N. Kanaan. "Rathke cleft cyst apoplexy: Hormonal and clinical presentation." Surgical Neurology International 12 (October 6, 2021): 504. http://dx.doi.org/10.25259/sni_382_2021.

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Background: Rathke cleft cyst (RCC) apoplexy is an uncommon type of lesion that is challenging to diagnose without histopathological samples. Very few articles have been published describing the details of RCC apoplexy. We studied a good number of published articles to analyze its demographics, clinical and hormonal presentations, and outcomes. Methods: A literature review of English language publications about RCC apoplexy or pituitary apoplexy was conducted using Medline and EMBASE search engines. Thirty articles with histological diagnosis of RCC apoplexy were identified, the earliest of wh

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21

Mumert, Michael L., Michael T. Walsh, Steven S. Chin, and William T. Couldwell. "Cystic granular cell tumor mimicking Rathke cleft cyst." Journal of Neurosurgery 114, no. 2 (2011): 325–28. http://dx.doi.org/10.3171/2010.5.jns1058.

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Symptomatic granular cell tumors of the neurohypophysis are a rarely reported entity. To the authors' knowledge, they report the first fully described case of a symptomatic granular cell tumor with a large cystic component. A 31-year-old woman presented with headaches and visual complaints with imaging findings confirming a cystic sellar and suprasellar mass. The lesion was resected, and histological examination confirmed the diagnosis. The literature has shown that granular cell tumors are rarely reported as being symptomatic but may actually be a fairly common finding in autopsy studies. The

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22

Swanson, S. E., W. F. Chandler, J. Latack, and K. Zis. "Symptomatic Rathke??s cleft cyst with pituitary adenoma." Neurosurgery 17, no. 4 (1985): 657???9. http://dx.doi.org/10.1097/00006123-198510000-00022.

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23

McLaughlin, Nancy, François Lavigne, Shaun Kilty, France Berthelet, and Michel W. Bojanowski. "Hypophysitis Secondary to a Ruptured Rathke Cleft Cyst." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 37, no. 3 (2010): 402–5. http://dx.doi.org/10.1017/s0317167100010349.

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24

Kim, Jeong Eun, and Hee-Won Jung. "Diagnosis and Treatment of Symptomatic Rathke Cleft Cyst." Neurosurgery Quarterly 13, no. 2 (2003): 64–76. http://dx.doi.org/10.1097/00013414-200306000-00002.

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25

Zada, Gabriel, Benjamin Ditty, Sean A. McNatt, J. Gordon McComb, and Mark D. Krieger. "SURGICAL TREATMENT OF RATHKE CLEFT CYSTS IN CHILDREN." Neurosurgery 64, no. 6 (2009): 1132–38. http://dx.doi.org/10.1227/01.neu.0000341873.20737.56.

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Abstract OBJECTIVE Rathke cleft cysts (RCCs) are cystic epithelial lesions in the sellar and suprasellar regions that are often discovered incidentally. They require surgical fenestration and drainage in a small proportion of patients who develop symptoms or demonstrate progressive enlargement. Our aim was to review our experience with pediatric patients treated surgically for RCCs. METHODS A retrospective review was conducted of all patients treated surgically for RCCs at Childrens Hospital Los Angeles between 1999 and 2007 after approval by the institutional review board. Clinical notes, ope

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26

Zada, Gabriel. "Rathke cleft cysts: a review of clinical and surgical management." Neurosurgical Focus 31, no. 1 (2011): E1. http://dx.doi.org/10.3171/2011.5.focus1183.

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The aim of this paper is to provide a comprehensive review of clinical, imaging, and histopathological features, as well as operative and nonoperative management strategies in patients with Rathke cleft cysts (RCCs). A literature review was performed to identify previous articles that reported surgical and nonsurgical management of RCCs. Rathke cleft cysts are often incidental lesions found in the sellar and suprasellar regions and do not require surgical intervention in the majority of cases. In symptomatic RCCs, the typical clinical presentation includes headache, visual loss, and/or endocri

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27

Fan, Jun, Yuping Peng, Songtao Qi, Xi-an Zhang, Binghui Qiu, and Jun Pan. "Individualized surgical strategies for Rathke cleft cyst based on cyst location." Journal of Neurosurgery 119, no. 6 (2013): 1437–46. http://dx.doi.org/10.3171/2013.8.jns13777.

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Object An assessment regarding both surgical approaches and the extent of resection for Rathke cleft cysts (RCCs) based on their locations has not been reported. The aim of this study was to report the results of a large series of surgically treated patients with RCCs and to evaluate the feasibility of individualized surgical strategies for different RCCs. Methods We retrospectively reviewed 87 cases involving patients with RCCs (16 intrasellar, 50 intra- and suprasellar, and 21 purely suprasellar lesions). Forty-nine patients were treated via a transsphenoidal (TS) approach, and 38 were treat

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28

Zhang, Yang, Chaoyue Chen, Zerong Tian, Yangfan Cheng, and Jianguo Xu. "Differentiation of Pituitary Adenoma from Rathke Cleft Cyst: Combining MR Image Features with Texture Features." Contrast Media & Molecular Imaging 2019 (October 28, 2019): 1–9. http://dx.doi.org/10.1155/2019/6584636.

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Objectives. To differentiate pituitary adenoma from Rathke cleft cyst in magnetic resonance (MR) scan by combing MR image features with texture features. Methods. A total number of 133 patients were included in this study, 83 with pituitary adenoma and 50 with Rathke cleft cyst. Qualitative MR image features and quantitative texture features were evaluated by using the chi-square tests or Mann–Whitney U test. Binary logistic regression analysis was conducted to investigate their ability as independent predictors. ROC analysis was conducted subsequently on the independent predictors to assess t

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29

Wait, Scott D., Mark P. Garrett, Andrew S. Little, Brendan D. Killory, and William L. White. "Endocrinopathy, Vision, Headache, and Recurrence After Transsphenoidal Surgery for Rathke Cleft Cysts." Neurosurgery 67, no. 3 (2010): 837–43. http://dx.doi.org/10.1227/01.neu.0000374768.16291.03.

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Abstract BACKGROUND Rathke cleft cyst can enlarge and become symptomatic. OBJECTIVE To review the clinical data and results of all patients treated by the senior author for a Rathke cleft cyst. METHODS A prospectively maintained surgical database, supplemented with updates from telephone conversations, of all patients presenting to the Barrow Neurological Institute from 1992 to the present was reviewed. RESULTS Seventy-three patients (17 males, 56 females; mean age, 40 years; range, 5–80 years) underwent 77 resections. The mean length of follow-up was 27 months (range, 0–129 months). Presentin

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30

Hamouda, Karim Ben, Moncef Khaldi, Hafedh Jemel, Mounir Ben Ismail, and Ihsen Zemmel. "Rathke cleft cyst of the sphenoid bone and nasopharynx." Journal of Neurosurgery 103, no. 6 (2005): 1095. http://dx.doi.org/10.3171/jns.2005.103.6.1095.

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31

Wagle, V. G., D. Nelson, A. Rossi, and D. Uphoff. "Magnetic resonance imaging of symptomatic Rathke??s cleft cyst." Neurosurgery 24, no. 2 (1989): 276???8. http://dx.doi.org/10.1097/00006123-198902000-00021.

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32

Gao, Mingtong, Yanyan An, Zhihong Huang, et al. "The Coexistence of Rathke Cleft Cyst and Pituitary Adenoma." Journal of Craniofacial Surgery 27, no. 2 (2016): e128-e130. http://dx.doi.org/10.1097/scs.0000000000002371.

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33

Cao, Zhikai, Jianping Lv, Zhengbin Ding, and Hong Du. "Pathological laughter in a patient with Rathke cleft cyst." Journal of Clinical Neuroscience 15, no. 11 (2008): 1279–82. http://dx.doi.org/10.1016/j.jocn.2007.08.030.

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34

Kim, Ealmaan. "Symptomatic Rathke Cleft Cyst: Clinical Features and Surgical Outcomes." World Neurosurgery 78, no. 5 (2012): 527–34. http://dx.doi.org/10.1016/j.wneu.2011.12.091.

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35

Hayashi, Yasuhiko, Daisuke Kita, Issei Fukui, et al. "Pediatric symptomatic Rathke cleft cyst compared with cystic craniopharyngioma." Child's Nervous System 32, no. 9 (2016): 1625–32. http://dx.doi.org/10.1007/s00381-016-3160-9.

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36

Yamamuro, Shun, Sodai Yoshimura, Hideki Oshima, and Atsuo Yoshino. "A case of Rathke cleft cyst concomitant with sellar/suprasellar arachnoid cyst." Acta Neurologica Belgica 117, no. 2 (2016): 561–63. http://dx.doi.org/10.1007/s13760-016-0705-3.

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37

Ung, Timothy H., Michael Yang, Mary Wang, Tessa Harland, and Kevin O. Lillehei. "Benefit of Intracystic Bleomycin for Symptomatic Recurrent Rathke Cleft Cyst." Operative Neurosurgery 17, no. 3 (2018): 268–72. http://dx.doi.org/10.1093/ons/opy361.

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Abstract BACKGROUND Management of recurrent Rathke cleft cysts (RCC) is problematic. The mainstay of treatment has been reoperation with cyst drainage. Radical cyst resection, although effective, results in a high incidence of diabetes insipidus. Several case reports suggest a potential benefit to radiation therapy or the use of intracystic bleomycin. The intracystic application of bleomycin is known to be beneficial in the treatment of cystic craniopharyngioma; however, its usefulness in the treatment of recurrent RCC has yet to be proven. OBJECTIVE To present our 6-yr experience using intrac

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38

Shatri, Jeton, and Ilir Ahmetgjekaj. "Rathke's Cleft Cyst or Pituitary Apoplexy: A Case Report and Literature Review." Open Access Macedonian Journal of Medical Sciences 6, no. 3 (2018): 544–47. http://dx.doi.org/10.3889/oamjms.2018.115.

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BACKGROUND: During the examination of the sellar region by magnetic resonance imaging, hyperintensity in T1 weighted is a common finding. This signal intensity has different sources, and its significance depends on the clinical context. Pathologic variations in T1 signal hyperintensity may be related to clotting of blood (pituitary apoplexy) or the presence of a high concentration of protein (Rathke cleft cyst). The purpose of this study is to describe the significance of intracystic nodule, a diagnostic characteristic found in Rathke's cleft cyst, on MRI.CASE REPORT: We will present the case

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39

Shepard, Matthew J., Mohamed A. Elzoghby, Erin N. Kiehna, Spencer C. Payne, and John A. Jane. "Presentation and outcomes in surgically and conservatively managed pediatric Rathke cleft cysts." Journal of Neurosurgery: Pediatrics 21, no. 3 (2018): 308–14. http://dx.doi.org/10.3171/2017.9.peds17400.

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OBJECTIVERathke cleft cysts (RCCs) are sellar lesions that are commonly encountered in adults but infrequently diagnosed in the pediatric population. As a result, the optimal management of pediatric RCCs remains a subject of controversy. Only 2 prior surgical series have been published on pediatric RCCs and no study has compared the presentation and outcomes of surgically versus conservatively managed cases. The authors therefore performed a comparative analysis of pediatric cases of RCC in which patients were treated with surgery or managed in a conservative manner.METHODSAll cases involving

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40

Radhakrishnan, VV, Neelima Radhakrishnan, Girish Menon, and DivyataRajendra Hingwala. "Non-functioning pituitary adenoma and concomitant Rathke′s cleft cyst." Indian Journal of Pathology and Microbiology 54, no. 3 (2011): 649. http://dx.doi.org/10.4103/0377-4929.85135.

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41

Yip, Chi-Man, Hui-Hwa Tseng, Shu-Shong Hsu, and Huang-I. Hsu. "Rathke Cleft Cyst with a Coexisting Gonadotropin Producing Pituitary Adenoma." Open Journal of Modern Neurosurgery 05, no. 03 (2015): 71–75. http://dx.doi.org/10.4236/ojmn.2015.53012.

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42

Bonneville, J. F. "Hemorrhagic Pituitary Adenoma versus Rathke Cleft Cyst: A Frequent Dilemma." American Journal of Neuroradiology 37, no. 3 (2015): E27—E28. http://dx.doi.org/10.3174/ajnr.a4653.

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43

Samadian, Mohammad, Kaveh Ebrahim Zadeh, karim Moradian Kokhdan, et al. "Symptomatic Rathke�s Cleft Cyst Presenting With Decreased Visual Acuity." Iranian Journal of Neurosurgery 4, no. 1 (2018): 41–44. http://dx.doi.org/10.32598/irjns.4.1.41.

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44

MIYAGI, Atsushi, Mitsuyoshi IWASAKI, Tadashi SHIBUYA, et al. "Pituitary Adenoma Combined with Rathke''s Cleft Cyst —Case Report—." Neurologia medico-chirurgica 33, no. 9 (1993): 643–50. http://dx.doi.org/10.2176/nmc.33.643.

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45

Chaiban, Joumana T., Dima Abdelmannan, Mark Cohen, Warren R. Selman, and Baha M. Arafah. "Rathke cleft cyst apoplexy: a newly characterized distinct clinical entity." Journal of Neurosurgery 114, no. 2 (2011): 318–24. http://dx.doi.org/10.3171/2010.5.jns091905.

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Object Although most Rathke cleft cysts (RCCs) remain asymptomatic, some present with compression of surrounding structures and pituitary hormone dysfunction. A rare, but distinct presentation of the RCC includes hemorrhage into the cyst—a presentation that mimics the clinical syndrome of pituitary tumor apoplexy. The objective of this article is to present the authors' experience on the prevalence and the clinical, biochemical, pathological, and imaging characteristics of hemorrhage into an RCC and review published reports on this entity. Methods An institutional database for patients with pi

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46

Acharya, Shrikrishna, Raju Gopal, Padma Menon, Tushar Bandgar, and Nalini Shah. "Precocious Puberty Due to Rathke Cleft Cyst in a Child." Endocrine Practice 15, no. 2 (2009): 134–37. http://dx.doi.org/10.4158/ep.15.2.134.

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47

Nishimura, Fumihiko, Yong-Soo Park, Yasushi Motoyama, et al. "Intractable Rathke Cleft Cyst Hidden Behind Coexisting Giant Pituitary Adenoma." World Neurosurgery 124 (April 2019): 9–11. http://dx.doi.org/10.1016/j.wneu.2018.12.105.

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48

Yokota, Hiroshi, Yuki Ida, Daisuke Wajima, Fumihiko Nishimura, and Hiroyuki Nakase. "Rathke Cleft Cyst with Evidence of Rupture into Subarachnoid Space." World Neurosurgery 97 (January 2017): 752.e1–752.e3. http://dx.doi.org/10.1016/j.wneu.2016.10.072.

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49

Altuwaijri, Njoud, David J. Cote, Nayan Lamba, et al. "Headache Resolution After Rathke Cleft Cyst Resection: A Meta-Analysis." World Neurosurgery 111 (March 2018): e764-e772. http://dx.doi.org/10.1016/j.wneu.2017.12.170.

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50

Lin, Yu-Hsiang, Hung-Lin Lin, and Der-Yang Cho. "Tension Pneumoventricle After Endoscopic Transsphenoidal Surgery for Rathke Cleft Cyst." World Neurosurgery 135 (March 2020): 228–32. http://dx.doi.org/10.1016/j.wneu.2019.12.065.

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