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Journal articles on the topic 'Rational drug therapy'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Dhaneria, S. "Rational drug therapy." Indian Journal of Community and Family Medicine 2, no. 1 (2016): 20. http://dx.doi.org/10.4103/2395-2113.251735.

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Dinçoğlu, Hacer. "Diabetes mellitus, insulin therapy, oral antidiabetic, rational drug use." Journal of Turkish Family Physician 11, no. 3 (2020): 131–40. http://dx.doi.org/10.15511/tjtfp.20.00331.

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Diabetes mellitus (DM); is a metabolic progressive di-sease with a rapidly increasing prevalence. The most important factors in the treatment of DM is the education of individuals with diabetes and rational drug use. Multiple insulin therapy is started with the diagnosis in type 1 DM (T1DM), oral antidiabetic drugs (OAD) and insulin treatments are initiated together according to the glycemic status in Type 2 DM (T2DM). Problems causing irrational drug use related to OAD in DM; advanced age, multidrug use, complex drug intake program, lack of knowledge, drug-related side effects, and patient di

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Maksimov, M. L., А. А. Zvegintseva, and А. А. Shikaleva. "Principles of antibiotic therapy in surgical practice. What should a practitioner not forget about?" Hirurg (Surgeon), no. 3 (June 30, 2024): 28–37. http://dx.doi.org/10.33920/med-15-2403-03.

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The rational use of antimicrobial drugs in surgery includes the correct choice of drug, its timely administration, minimizing the duration of therapy and switching to oral forms, regular monitoring and use of microbiological research data. These principles help reduce the risk of infections, minimize side effects, and prevent the development of antibiotic resistance. This article reviews basic information about the principles of rational initiation of antibiotic therapy, perioperative antibiotic prophylaxis, the rational choice of an antibacterial drug, the dose of the antibiotic, the mode of

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Padh, H., Neelam Chauhan, and Shubha Rani. "Pharmacogenetics: Genetic basis for rational drug therapy." Indian Journal of Pharmaceutical Sciences 69, no. 2 (2007): 180. http://dx.doi.org/10.4103/0250-474x.33140.

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Caird, F. I. "Towards Rational Drug Therapy in Old Age." Journal of the Royal College of Physicians of London 19, no. 4 (1985): 235–39. https://doi.org/10.1016/s0035-8819(25)02493-6.

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Faizullin, Sh B., and M. S. Musin. "Principles of rational selection and use of drug combinations." Kazan medical journal 67, no. 5 (1986): 397–400. http://dx.doi.org/10.17816/kazmj70726.

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Advances in pharmacy, pharmacology in recent years and the rapid development of the chemical-pharmaceutical industry have significantly expanded the arsenal of drugs used, the number of which continues to increase. With the introduction into practice of new drugs, the possibilities of etiotropic and pathogenetic therapy have increased. However, at the same time as the effectiveness of drug therapy has increased, it has become less safe. In recent years, cases of drug-induced side effects, which often exceed the severity of the underlying disease, have increased.

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Beyth, Rebecca J., and Ronald I. Shorr. "Principles of drug therapy in older patients: rational drug prescribing." Clinics in Geriatric Medicine 18, no. 3 (2002): 577–92. http://dx.doi.org/10.1016/s0749-0690(02)00017-4.

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Khadka, Sitaram, Hamid Saeed, Janak Shahi, Yogesh Bajgain, Tank Prasad Yadav, and Ravi Prasad Gupta. "Utilizing Hospital Formulary System in Nepal." Journal of Nepal Health Research Council 18, no. 2 (2020): 337–39. http://dx.doi.org/10.33314/jnhrc.v18i2.2647.

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Since the early 1950s, for medication management, the hospital formulary system subsisted as a list of drugs into the supply chain management process in hospitals. With the advent of pharmacy practice services, the system now is more oriented towards the rational use of drugs taking into account the safety of therapy, cost-effectiveness, and uninterrupted availability of drugs to improve and reflect upon the clinical judgment of healthcare professionals. Though very few hospitals in Nepal have adopted hospital formulary system, the perfect practice is still skimpy. The formation of drug and th

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Babu, Thirunavukkarasu Arun. "Rational drug therapy in children: An unrealized dream." Pediatric Companion 2, no. 1 (2023): 24–25. http://dx.doi.org/10.4103/pedc.pedc_19_23.

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Mahmood, Fawad, Shahid Anwar, Ayesha Javaid, Moiz Inam Khan, Bilal Ahmed, and Abad Khan. "Rational Drug Therapy for the Management of Diabetes Mellitus." Pakistan Journal of Medical and Health Sciences 16, no. 8 (2022): 902–5. http://dx.doi.org/10.53350/pjmhs22168902.

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Diabetes Mellitus is one of the major worldwide public health issues, along with socio-economic growth. Diabetes Mellitus is a chronic metabolic syndrome of several causes characterized by long-lasting hyperglycemia with the turmoil of carbohydrates. The study aimed to evaluate pharmacotherapy on rational grounds for drug-drug interactions, polypharmacy, and untreated conditions if any., For the recording of patient case histories, a standard questionnaire was designed, which includes age, sex, history, chief complaints, Clinical tests, diagnosis & patient’s family history, etc., the copy

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Leary, Meghan, Sarah Heerboth, Karolina Lapinska, and Sibaji Sarkar. "Sensitization of Drug Resistant Cancer Cells: A Matter of Combination Therapy." Cancers 10, no. 12 (2018): 483. http://dx.doi.org/10.3390/cancers10120483.

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Cancer drug resistance is an enormous problem. It is responsible for most relapses in cancer patients following apparent remission after successful therapy. Understanding cancer relapse requires an understanding of the processes underlying cancer drug resistance. This article discusses the causes of cancer drug resistance, the current combination therapies, and the problems with the combination therapies. The rational design of combination therapy is warranted to improve the efficacy. These processes must be addressed by finding ways to sensitize the drug-resistant cancers cells to chemotherap

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Shah, Fawad Ali, Muhammad Imran Khan, Bashir Ahmad, and Shabir Hussain. "Drug interaction and rational drug therapy in hospitalized patients reported with stroke." Journal of Bashir Institute of Health Sciences 1, no. 1 (2020): 15–22. http://dx.doi.org/10.53576/bashir.01.01.0017.

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Objective: The purpose of the current study was to determine prescription rationalities, any pharmacotherapy-based problems, and to determine drug interactions in patients with stroke. Methods: Patient case histories were determined using a standard questionnaire form having a patient tag, age, sex, past history, chief complaints, biochemical tests, treatment chart and other relevant information. Forty patients suffering from stroke and were on treatment were selected for the current study. The relevant information was recorded with respect to patient demographic data, disease incidence, drug

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Polyakova, Polyakova O. A., Ostroumova O. D. Ostroumova, and Arablinsky A. V. Arablinsky. "Drug safety and polymorbidity as important components of rational pharmacotherapy in cardiology." Therapy 4_2022 (June 10, 2022): 141–48. http://dx.doi.org/10.18565/therapy.2022.4.141-148.

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Emelianov, I. V., and A. O. Konradi. "Rational combination therapy in resistant arterial hypertension." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 17, no. 4 (2011): 384–90. http://dx.doi.org/10.18705/1607-419x-2011-17-4-384-390.

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T., G. Romanenko, M. Zhaloba G., and М. Sulimenko О. "RATIONAL THERAPY OF BACTERIAL VAGINOSIS." REPRODUCTIVE ENDOCRINOLOGY, no. 55 (November 30, 2020): 58–61. https://doi.org/10.18370/2309-4117.2020.55.58-61.

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<strong>Purpose of the study</strong> was to evaluate the efficiency and duration of clindamycin (Banbact®) therapeutic effect  in the treatment of bacterial vaginosis in women of reproductive age. <strong>Materials and methods.</strong> The study included 47 patients with bacterial vaginosis aged 20–37 years. Vaginal dysbiosis was established on the basis of symptoms indicated by women themselves, results of gynecological examination that was consisting of examination, measurement of vaginal pH based on the Amsels criteria, evaluation of vaginal microbiocenosis by pol

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Jaiswal, Mahendra K., Rajnesh K. Chakrawarty, Sanat K. Sharma, Raj K. Sharma, Rupendra K. Bharti, and Ratna Agrawal. "A world health organization core drug use indicator based prescription study in the dermatology outpatient department of a tertiary care teaching hospital of central South India." International Journal of Basic & Clinical Pharmacology 8, no. 8 (2019): 1896. http://dx.doi.org/10.18203/2319-2003.ijbcp20193198.

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Background: Irrational prescribing is a universal problem that may lead to inadequate response to medication therapy, poor patient compliance and increased adverse drug reactions ultimately leading to frequent hospital admissions. Hence this study was done to assess the drug utilization pattern using WHO core drug use indicators so that the recommendation can be made towards the rational prescribing.Methods: A sample of 3650 prescriptions was analysed prospectively to assess the drug utilization patterns in the dermatology OPD of a tertiary care teaching hospital of central south India.Results

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G.D., Torezhanova, Amantai A.T., Kuderinova M.K., Nikolaeva T.L., and Kim T.V. "INFLUENCE OF BIOPHARMACEUTICAL FACTORS ON THE THERAPEUTIC ACTIVITY OF MEDICINAL SUBSTANCES." ИННОВАЦИОННЫЕ НАУЧНЫЕ ИССЛЕДОВАНИЯ 2022. 11-3(23) (December 4, 2022): 12–21. https://doi.org/10.5281/zenodo.7395890.

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At present, the main goal of the development of the clinical direction in pharmacy is to increase the efficiency and safety of drug therapy. The scientific article discusses the main ways to optimize drug therapy, the rules for storing dosage forms and the rational use of drugs. The scientific article discusses the influence of pharmaceutical factors on the therapeutic activity of dosage forms. With the help of questionnaire-analytical, statistical and analytical methods, a conclusion is made about how people use medicines in everyday living conditions. In conclusion, they get acquainted with

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Gorantla, Naveen Choudary, and Lalitha Hanumanthu. "Drug utilization study in outpatient ophthalmology department of government medical college, Nellore, India." International Journal of Basic & Clinical Pharmacology 7, no. 5 (2018): 844. http://dx.doi.org/10.18203/2319-2003.ijbcp20181425.

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Background: Drug utilization studies are an important part of rational use of drugs. This study was planned to assess drug utilization pattern in Ophthalmology outpatient department.Methods: After approval from Ethics Committee, 620 prescriptions were analyzed according to WHO drug indicators.Results: 2. 4 drugs were prescribed on an average per prescription. Antibiotics (49%) were the most commonly used drugs. Fluoroquinolones (54%) were frequently used. Topical route was preferred route of drug administration. Prescription of generic drugs was not optimal (13%). Duration of therapy was missi

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Kazakov, Alexander S., Sergey K. Zyryanov, Elena A. Ushkalova, and Elena K. Nasretdinova. "Rational treatment of patients with functional dyspepsia." Terapevticheskii arkhiv 93, no. 8 (2021): 982–85. http://dx.doi.org/10.26442/00403660.2021.08.200984.

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Functional dyspepsia is one of the most common functional disorders of the gastrointestinal tract, which resulted from impaired motor skills, visceral hypersensitivity, increased mucosal permeability, disorders of the autonomic nervous system, etc. There is no specific therapy for this disease, which often leads to the irrational use of various groups of drugs. Drug therapy is recommended only during periods of symptoms. The main options of pharmacotherapy include the use of proton pump inhibitors, phytotherapeutic drugs, eradication therapy of Helicobacter pylori. Against the background of po

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Evans, William E., and Mary V. Relling. "Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics." Science 286, no. 5439 (1999): 487–91. http://dx.doi.org/10.1126/science.286.5439.487.

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Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution.

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Kotlukov, V. К., T. V. Kazyukova, and N. V. Antipova. "Rational antipyretic therapy of arvi in children." Medical Council, no. 17 (October 22, 2018): 109–13. http://dx.doi.org/10.21518/2079-701x-2018-17-109-113.

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The article presents data on the clinical features of ARVI in children: description of the febrile syndrome as one of the leading symptoms in these infections, the use of Panadol as the drug of choice during the anti-pyretic therapy in children.

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Solodovnik, V. O., and A. G. Bashta. "The role of the nurse in rational antibioticotherapy." Infusion & Chemotherapy, no. 3.1 (October 11, 2020): 74. http://dx.doi.org/10.32902/2663-0338-2020-3.1-61.

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Objective. A study of the role of the nurse in carrying out rational therapy with the analysis of data of research of treatment of patients on the basis of City Hospital № 21 of Dnipro for 2019. Materials and methods. A study of 50 case histories of patients with infectious diseases of the upper respiratory tract aged 18 to 60 years who required treatment with antibiotics was conducted. Ways and methods of antibiotic therapy were studied. An analysis of the possibilities of the nurse’s influence on antibiotic therapy was performed. Results and discussion. According to the results o

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Singh, Jeetendra M., Tushar C. Baheti, and Rakesh Verma. "To assess awareness regarding rational drug therapy and fixed dose combinations amongst interns and II MBBS students in tertiary care teaching hospital in Maharashtra, India." International Journal of Basic & Clinical Pharmacology 7, no. 1 (2017): 27. http://dx.doi.org/10.18203/2319-2003.ijbcp20175526.

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Background: The present study was designed to assess awareness regarding rational drug therapy and fixed dose combinations (FDC) amongst interns and II MBBS students in a tertiary-care teaching hospital in Maharashtra, India.Methods: This cross-sectional, questionnaire-based study containing MCQ and analytical questions on rational drug therapy, fixed dose combinations and role of Pharmacist in dispensing correct drug to the patients was carried out in both interns (n=80) and II MBBS students (n=100). The completed questionnaires were then collected and analysed statistically for responses.Res

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Lipton, Helene Levens, Patricia J. Byrns, Stephen B. Soumerai, and Elizabeth A. Chrischilles. "Pharmacists as Agents of Change for Rational Drug Therapy." International Journal of Technology Assessment in Health Care 11, no. 3 (1995): 485–508. http://dx.doi.org/10.1017/s0266462300008692.

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AbstractWe analyze what is known and unknown about the contribution of the pharmacist as patient educator, physician consultant, and agent to affect patient outcomes in ambulatory settings. The need for pharmacist services is discussed, as are the theoretical underpinnings and quality of the scientific evidence to support their efficacy. The analysis is conducted in the context of a shift in pharmacists' roles from product to patient orientation as well as recent U.S. legislation mandating enhanced pharmacists' roles via drug utilization review for all Medicaid patients. We conclude with a res

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Shi, Shaojun, Klaus Mörike, and Ulrich Klotz. "The clinical implications of ageing for rational drug therapy." European Journal of Clinical Pharmacology 64, no. 2 (2008): 183–99. http://dx.doi.org/10.1007/s00228-007-0422-1.

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Mooij, M., J. Windster, J. van Rosmalen, L. Hanff, D. Tibboel, and S. de Wildt. "P68 Significant oral drug use in critically ill children: rational therapy or a black box?" Archives of Disease in Childhood 104, no. 6 (2019): e45.2-e45. http://dx.doi.org/10.1136/archdischild-2019-esdppp.106.

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BackgroundThe disposition of orally prescribed drugs in critically ill children may be affected critical illness in in addition to age, resulting in erratic effects and safety. We aimed to study oral drug prescribing in the neonatal and pediatric intensive care unit (NICU and PICU).MethodsA one-year retrospective cohort study of all drug prescriptions, including route of administration for all children admitted to the NICU and PICU of the Erasmus MC-Sophia’s children’s hospital.Results1723 children with 2091 unique admissions received per admission (median [IQR]) 5 (3–10) drugs; 1 (0–2) orally

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Hidayat, Rahmat, and Yeni Karneli. "Efektivitas Pendekatan Rational Emotive Behavior Therapy Setting Kelompok untuk Meningkatkan Kontrol Diri Siswa dalam Pencegahan Penyalahgunaan Narkoba." ITQAN: Jurnal Ilmu-ilmu Kependidikan 13, no. 2 (2022): 199–208. http://dx.doi.org/10.47766/itqan.v13i2.525.

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Drug abuse is a negative/irrational behavior that can harm oneself and others. One of the causes of drug abuse is the low self-control of students. Clients who have problems with low self-control in drug abuse need to be counseled through rational emotive behavior therapy in group settings. The aims of this study were: (1) to test the significant difference in the level of self-control of the experimental group students before and after being given the rational emotive behavior therapy setting technique, (2) to test the significant difference in the level of self-control of the control group s

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Ahmed, Md Mohsin, Amogh Harsoor, and Sana Nizami. "A prospective study of drug utilization in patients attending ophthalmology outpatient department at KBN teaching and general hospital of Gulbarga, India." International Journal of Basic & Clinical Pharmacology 7, no. 8 (2018): 1512. http://dx.doi.org/10.18203/2319-2003.ijbcp20183003.

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Background: Drug utilization studies are an important part of rational use of drugs. Assessment of drug use pattern especially in developing countries is becoming increasingly necessary to promote the rational use of drugs. This study was planned to prospectively assess the drug utilization pattern in Ophthalmology outpatient department at KBN teaching and General hospital.Methods: After approval from Ethics Committee, the prescriptions of 1000 outpatients were analyzed using a predesigned form to record information from the OPD prescriptions. Mentioned WHO drug use indicators and additional i

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Franchin, Giovanni, Elena Peeva, and Betty Diamond. "Pathogenesis of SLE: implications for rational therapy." Drug Discovery Today: Disease Mechanisms 1, no. 3 (2004): 303–8. http://dx.doi.org/10.1016/j.ddmec.2004.11.009.

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Morozova, T. E., T. B. Andruschishina, and D. G. Shmarova. "Rational pharmacotherapy of hypertension. Urapidil potential." Systemic Hypertension 10, no. 4 (2013): 38–43. http://dx.doi.org/10.26442/sg28982.

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Optimizing pharmacotherapy of arterial hypertension (AH) and varied selection of medicines remains an urgent problem for practitioners. However, despite the large variety of effective antihypertensive drugs, the control of blood pressure levels remains inadequate. Most patients require combined therapy with two or more agents to achieve target blood pressure levels, so the choice of second-line therapy is of particular importance. As adjunctive therapy in patients with uncontrolled hypertension a-blockerscan be used, which, in addition to the antihypertensive effect, have a number of other ben

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Jagadish, Chandra Benur, Krupali, S. Hanchinal Shivaraj, and V. Bomman Jairaj. "Drug Utilization Pattern of Antihypertensive Drugs at Tertiary Care Teaching Hospital." International Journal of Pharmaceutical and Clinical Research 16, no. 7 (2024): 657–62. https://doi.org/10.5281/zenodo.13119307.

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<strong>Background:</strong> Drug utilization studies conducted at regular intervals help to guide the physician in prescribing drugs rationally. <strong>Methods:</strong> A prospective, observational study was conducted in the outpatient of department of general medicine of Gims kalaburgi a tertiary care teaching hospital. Data was collected from patients who have been diagnosed with hypertension as per JNC-8 guidelines and patients receiving or prescribed with antihypertensive medica-tions were included. Frequency and proportions of utilization of antihypertensive medications

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Fernández, Ariel, Angela Sanguino, Zhenghong Peng, et al. "Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target." Cancer Research 67, no. 9 (2007): 4028–33. http://dx.doi.org/10.1158/0008-5472.can-07-0345.

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Fernandez, A., A. Sanguino, Z. Peng, et al. "Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target." AACR Education book 2008, no. 1 (2008): 589–99. http://dx.doi.org/10.1158/aacr.edb-can-07-0345.

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Amundstuen Reppe, Linda, Olav Spigset, and Jan Schjøtt. "Drug Information Services Today: Current Role and Future Perspectives in Rational Drug Therapy." Clinical Therapeutics 38, no. 2 (2016): 414–21. http://dx.doi.org/10.1016/j.clinthera.2015.12.019.

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Boothe, Dawn Merton. "Drug therapy in cats: Recommended dosing regimens." Journal of the American Veterinary Medical Association 196, no. 11 (1990): 1845–50. http://dx.doi.org/10.2460/javma.1990.196.11.1845.

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Summary The goal of this series of articles has been to provide a comprehensive review of the literature regarding recommended dosing regimens, therapeutic indications and contraindications, and potential side effects of drugs used in cats. In this fourth and last article, the available information regarding dosage regimens in cats has been consolidated in tabular form to facilitate an effective and rational approach to the pharmacologic prevention and treatment of a variety of feline medical disorders.

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Lakshmi, Chaitanya, Mr Babitha, Mr Ramesh, Mr Dhanapal, and Mr Manavalan. "Role of clinical pharmacist in rational therapy of pediatric seizures." International Current Pharmaceutical Journal 1, no. 10 (2012): 328–31. http://dx.doi.org/10.3329/icpj.v1i10.11851.

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Seizures are more common in children than in any other age group, except the elderly. In fact, there are several kinds of seizures that affect only children. Sometimes children outgrow their seizures but many need to be treated for their seizures for their entire life. The main objectives of this study are to study the physician prescribing pattern in pediatric seizures and to educate the patient care taker about the disease and the use of drugs in order to control seizures and improve the quality of life. A non invasive prospective observational study was done with 86 pediatric patients from

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Baulac, Michel. "Rational conversion from antiepileptic polytherapy to monotherapy." Epileptic Disorders 5, no. 3 (2003): 125–32. http://dx.doi.org/10.1684/j.1950-6945.2003.tb00001.x.

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For patients with epilepsy, the goal of treatment is to achieve seizure freedom with minimal or no adverse events. Around 60%‐70% of newly diagnosed patients will achieve this goal with single antiepileptic drug (AED) therapy, and there is universal agreement that prescription of a single agent constitutes best practice for such patients. For the 30%‐40% of patients with poorly controlled epilepsy, treatment options are less clear and many receive add‐on therapy with one or more AEDs in an attempt to improve seizure control. Because the therapeutic gain from adjunctive therapy is often margina

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Bravo, E. L. "Rational drug therapy based on understanding the pathophysiology of hypertension." Cleveland Clinic Journal of Medicine 56, no. 4 (1989): 362–68. http://dx.doi.org/10.3949/ccjm.56.4.362.

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Bakracheva, N., A. Beltcheva, and E. Gatchev. "Skills of Bulgarian students in choosing a rational drug therapy." Int. Journal of Clinical Pharmacology and Therapeutics 40, no. 10 (2002): 472–73. http://dx.doi.org/10.5414/cpp40472.

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Braat, Sien, and R. Frank Kooy. "Fragile X syndrome neurobiology translates into rational therapy." Drug Discovery Today 19, no. 4 (2014): 510–19. http://dx.doi.org/10.1016/j.drudis.2014.01.013.

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Paul Otor Onah and Catherine Chioma Idoko. "Drug prescription pattern among patients on national health insurance at a tertiary care hospital in north east Nigeria." GSC Biological and Pharmaceutical Sciences 20, no. 1 (2022): 137–44. http://dx.doi.org/10.30574/gscbps.2022.20.1.0220.

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The quality of drug prescriptions is one of many determining factors of patient treatment outcomes. Irrational drug use is a significant contributor to adverse reactions and its associated morbidity and mortality among patients. In addition, it also increase the cost of medical care, reduce affordability of drugs and impose unnecessary financial cost for medical services. Evaluation of prescribing practices using appropriate tools is one of the many methods of assessing the quality and rational of drug use in healthcare facilities. The major objective of this study is to determine level of pol

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Paul, Otor Onah, and Chioma Idoko Catherine. "Drug prescription pattern among patients on national health insurance at a tertiary care hospital in north east Nigeria." GSC Biological and Pharmaceutical Sciences 20, no. 1 (2022): 137–44. https://doi.org/10.5281/zenodo.7124326.

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The quality of drug prescriptions is one of many determining factors of patient treatment outcomes. Irrational drug use is a significant contributor to adverse reactions and its associated morbidity and mortality among patients. In addition, it also increase the cost of medical care, reduce affordability of drugs and impose unnecessary financial cost for medical services. Evaluation of prescribing practices using appropriate tools is one of the many methods of assessing the quality and rational of drug use in healthcare facilities. The major objective of this study is to determine level of pol

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Boothe, Dawn Merton. "Drug therapy in cats: Mechanisms and avoidance of adverse drug reactions." Journal of the American Veterinary Medical Association 196, no. 8 (1990): 1297–305. http://dx.doi.org/10.2460/javma.1990.196.08.1297.

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Summary This is the first of a 4-part series concerning drug therapy in cats. In this article, factors that may increase the incidence of type-A adverse drug reactions in cats are discussed. Factors related to species and age differences, drug interactions, and the effects of disease are emphasized. Those that tend to be unique to cats, such as species-induced differences in drug disposition, are described in detail when sufficient information was available from the literature. General recommendations regarding drug administration are made, which will facilitate the implementation of rational

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Khan, Majid, Rahmat Ullah, Asaf Khan, Najm ur-Rahman, Sadaqat Khan, and Muhammad Riaz. "Assessment of Prescriptions in the Endocrinology Department of a Tertiary Care Hospital in Pakistan Using World Health Organization Guidelines." Advances in Preventive Medicine 2020 (May 30, 2020): 1–6. http://dx.doi.org/10.1155/2020/3705704.

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Background. It is essential to follow World Health Organization drug prescribing indicators to ensure rational prescribing in every health care setting. Objective. To evaluate the prescriptions in the endocrinology department, according to the World Health Organization (WHO), recommended Ghana guidelines for diabetes management and rational therapy. Methods. Concurrent and retrospective study design was used. The prescriptions of 100 diabetes patients were assessed for the type of medicine, dosage form, number of drugs, diabetes type, and deviation from standard guidelines. Results. In a total

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Viswanatha Swamy, AHM, Mahindra Kumar R, Sanat Nyamagoud, et al. "Assessment of Drug Utilization Pattern and Rational Use of Antihypertensive Therapy in Geriatric Patients: A Prospective Observational Study." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 72–77. http://dx.doi.org/10.22270/jddt.v12i1.5256.

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Background: Hypertension is one of the most frequently occurring noncommunicable diseases, and it causes a variety of cardiovascular complications and mortality. Diagnosis and treatment in elderly patients are very difficult due to their changes in physiology and physiological responses to the therapy. Drug utilization studies are plausible instrument in the evaluation in health care practice. Objective: To assess drug utilization pattern and rational use of antihypertensive therapy in geriatric patients. Materials and methods: This is a prospective observational study that took place in 200 i

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Cohen, Lawrence J. "Rational Drug Use in the Treatment of Depression." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 17, no. 1 (1997): 45–61. http://dx.doi.org/10.1002/j.1875-9114.1997.tb03677.x.

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New drugs are being developed for the management of depression in response to the growing awareness of the prevalence and disability associated with the disorder and the need for agents with improved side effect profiles. All antidepressants are equally effective for treating uncomplicated unipolar depression without psychotic features. For patients with atypical depression with prominent anxiety, agitation, sleep loss, and irritability, monoamine oxidase inhibitors are the first choice. Data are accumulating supporting the efficacy of selective serotonin reuptake inhibitors (SSRIs) in these d

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Tarnate, Paul Sherwin. "Rational Use of Polymyxins Against Multi-Drug Resistant Gram-Negative Bacteria." Pediatric Infectious Disease Society of the Philippines Journal 22, no. 1 (2021): 3–13. http://dx.doi.org/10.56964/pidspj2021220102.

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The current strategy in treating multi-drug resistant gram-negative bacterial (MDR-GNB) infections is salvage therapy by using polymyxins. However, the beginning emergence of polymyxin resistance should enforce strict antimicrobial stewardship programs to preserve polymyxin efficacy. Knowledge of structural characteristics, pharmacodynamic, and pharmacokinetic profiles of polymyxins, as well as consideration of efficacy, safety, suitability, and cost, will help in the choice of the appropriate polymyxin for therapy. Polymyxin B is the recommended polymyxin for systemic use, while colistin is r

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Ayata, C. "Spreading Depression: From Serendipity to Targeted Therapy in Migraine Prophylaxis." Cephalalgia 29, no. 10 (2009): 1095–114. http://dx.doi.org/10.1111/j.1468-2982.2009.01982.x.

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Despite the relatively well-characterized headache mechanisms in migraine, upstream events triggering individual attacks are poorly understood. This lack of mechanistic insight has hampered a rational approach to prophylactic drug discovery. Unlike targeted abortive and analgesic interventions, mainstream migraine prophylaxis has been largely based on serendipitous observations (e.g. propranolol) and presumed class effects (e.g. anticonvulsants). Recent studies suggest that spreading depression is the final common pathophysiological target for several established or investigational migraine pr

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Chandra, Shruti, Amol Ubale, Deepak Bhosle, Deepali Jayabhaye, and Sukhmeen Kaur. "A study of prescription pattern of the pharmacotherapy of patients of hypertension at a tertiary care hospital, Aurangabad,Maharashtra, India." International Journal of Basic & Clinical Pharmacology 8, no. 7 (2019): 1599. http://dx.doi.org/10.18203/2319-2003.ijbcp20192657.

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Background: The overall prevalence for hypertension in India was estimated to be 29.8%. Patient’s optimal adherence with antihypertensive drug therapy is essential for preventing serious complications with hypertension over the long term. Therefore, the present study was undertaken to evaluate the prescription pattern of the drugs prescribed to hypertensive patients.Methods: Present study was a prospective cross sectional observational study carried out in the outpatient of department of general medicine of MGM Hospital, a tertiary care teaching hospital, in Aurangabad. Prescriptions of 120 di

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Lu, Guoxiu. "Research progress on anti-infection therapy for sepsis in children." Infection International 7, no. 2 (2018): 44–49. http://dx.doi.org/10.2478/ii-2018-0018.

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Abstract Sepsis is a systemic inflammatory response caused by infection and a critical illness in pediatrics. This disease is the leading cause of death in infants and children worldwide. An early, appropriate, and adequate anti-infective treatment can effectively prevent disease progression and improve the survival rate of children. However, antimicrobial drug abuse, increased drug-resistant bacteria, and lack of epidemiological data have hampered the effective and rational anti-infective treatment of patients with sepsis and enhancement of the success rate of rescue, especially for children.

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