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Dissertations / Theses on the topic 'Rational drug use'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Giron, Maria Stella T. "The rational use of drugs in a population of very old persons /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-155-1.

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2

Cossins, Benjamin Philip. "The Use of Fast Free Energy Methods in Rational Drug Design." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485031.

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The computationally demanding nature and lack of generality of free energy methods are the main barriers to their common place use in rational drug design. This study investigates the possibility of producing protocols to accurately calculate the binding free energy of protein-ligand complexes more efficiently than presently established methods, using large scale distributed computing. There has been an explosion of useful nonequilibrium work methods recently, mainly due to the discovery of the Jarzynski equilibrium [Jarzynski(1997b)]. After an indepth investigation of these methods a subset,

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3

Oguntunde, Olugbenga Olalere. "Drug prescribing practices among primary healthcare providers in a local government area of Northwestern Nigeria." University of the Western Cape, 2011. http://hdl.handle.net/11394/5378.

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Master of Public Health - MPH<br>Background: Drugs are essential components of the health system and their rational use is vital to delivering quality and efficient healthcare services. However, inappropriate prescribing is a common rational drug use problem globally, particularly in developing countries including Nigeria. Despite measures to address this problem, inappropriate drug use continues to be a major public health problem in Nigeria. Aim: This study assessed rational drug use (RDU), with a focus on rational prescribing and factors affecting it, among primary healthcare providers wor

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4

Joshua, Isaac B. "The impact of an intervention program for the treatment of malaria in children in Papua New Guinea." Thesis, Curtin University, 2003. http://hdl.handle.net/20.500.11937/2339.

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Malaria is more prevalent today and the death toll is on the increase annually. It is one of the leading causes of morbidity and mortality worldwide and most of these deaths are in the poorest regions of the world. About 500 million cases are reported annually with more than 2 million deaths, and most are children. It is the major killer in the tropics and a major public health problem in developing countries and Papua New Guinea (PNG) is no exception. Resistant strains have been reported. This may be enhanced by inappropriate human behaviour in the use of anti-malarial drugs. Human factors in

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5

Alali, Khaled Y. A. A. "Development of National Drug Policy in the State of Kuwait." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/16793.

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This Thesis examines the benefits and usefulness of a National Drug Policy (NDP) for the developing of the Health Care System in Kuwait. The NDP is one of the most important structures of the Health System which can lead to improved health services by establishing guidelines, proposals and directives to organize, structure and regulate health legislation; it is of help to ensure the availability of quality, safety and efficacy in using medicines and it can reduce the irrational use of medicines. The NDP is a frame work between the government, schools and universities, media, health professiona

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6

Orrell, Catherine Jane. "The development, initial implementation and support of a primary health care training programme in rational drug use." Master's thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/26583.

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The Rational Drug Use Training Project is a district-oriented programme designed to improve rational drug use among primary health care prescribers in the South African public sector. This thesis describes the development of the project and details the initial implementation study in 3 facilities in Region B of KwaZulu-Natal. This was a small before-after study, with no control. There were three components: 1. A series of easily collectable drug use indicators, adapted from those developed by WHO/INRUD. These allow primary health care staff to monitor their prescribing patterns in a district o

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7

Joshua, Isaac B. "The impact of an intervention program for the treatment of malaria in children in Papua New Guinea." Curtin University of Technology, School of Pharmacy, 2003. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=13852.

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Malaria is more prevalent today and the death toll is on the increase annually. It is one of the leading causes of morbidity and mortality worldwide and most of these deaths are in the poorest regions of the world. About 500 million cases are reported annually with more than 2 million deaths, and most are children. It is the major killer in the tropics and a major public health problem in developing countries and Papua New Guinea (PNG) is no exception. Resistant strains have been reported. This may be enhanced by inappropriate human behaviour in the use of anti-malarial drugs. Human factors in

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8

Monanabela, Khathatso. "Rational drug therapy monitoring in type 2 diabetes mellitus : using glycated haemoglobin as a guide for change in therapy." University of the Western Cape, 2015. http://hdl.handle.net/11394/5305.

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>Magister Scientiae - MSc<br>Type 2 diabetes mellitus is a progressive disease characterised by defects in insulin secretion, insulin action or both. Proper management of diabetes with appropriate drug and lifestyle interventions, guided by proper glycaemic monitoring has shown improved glycaemic control and a substantial decrease in morbidity associated with complications and mortality. Evidence-based guidelines for the appropriate management of diabetes, suggests the use of glycated haemoglobin (HbA1c) and fasting plasma glucose (FPG) as monitoring indicators and have set targets levels that

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9

Olivera, Carolina Maria Xaubet. "Modelo de intervenções educativas para o uso racional de medicamentos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-28112013-152058/.

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O farmacêutico, uma vez inserido na equipe multidisciplinar, tem um papel importante a desempenhar na educação em saúde com o objetivo de melhorar o conhecimento sobre as condições crônicas, refletindo positivamente na adesão ao tratamento e em conseqüência nos resultados clínicos e na qualidade de vida dos indivíduos. O objetivo deste estudo foi elaborar, implementar e avaliar o modelo de intervenções educativas para o uso racional de medicamentos. O estudo clínico longitudinal, prospectivo, randomizado foi conduzido por uma equipe multidisciplinar com 119 pacientes asmáticos (60/grupo contro

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10

Tanner, Delia Caroline. "Over-expression, purification and biochemical characterization of DOXP reductoisomerase and the rational design of novel anti-malarial drugs." Thesis, Rhodes University, 2004. http://hdl.handle.net/10962/d1003990.

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Malaria poses the greatest threat of all parasites to human life. Current vaccines and efficacious drugs are available however their use is limited due to toxicity, emergence of drug resistance, and cost. The discovery of an alternative pathway of isoprenoid biosynthesis, the non-mevalonate pathway, within the malarial parasite has resulted in development of novel anti-malarial drugs. 1-Deoxy-D-xylulose-5-phosphate (DOXP) reductoisomerase, the second enzyme in this pathway, is responsible for the synthesis of 2-C-methyl-D-erythritol 4-phosphate (MEP) in an intramolecular rearrangement step fol

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11

Batista, Alm?ria Mariz. "Avalia??o da publicidade de medicamentos veiculada nas principais emissoras de r?dio de Natal-RN." Universidade Federal do Rio Grande do Norte, 2009. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13443.

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Made available in DSpace on 2014-12-17T14:16:23Z (GMT). No. of bitstreams: 1 AlmariaL_capa ao resumo.pdf: 98144 bytes, checksum: 4227b4b6b24148c41463e25c13ec11f0 (MD5) Previous issue date: 2009-07-02<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Drugs advertising is one of the most important marketing resources used by the pharmaceutical industry to induce people to buy these products although they do not have the real necessity to use them. The purpose of this article is to evaluate drugs advertisings transmitted on radio stations in Natal/RN, from October 2007 to Sept

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12

Araújo, Paulo Sérgio Teixeira de. "O uso dos medicamentos genéricos e sua relevância social : o caso da Policlínica Municipal de Campinas - São José." Universidade do Estado de Santa Catarina, 2007. http://tede.udesc.br/handle/handle/2205.

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Made available in DSpace on 2016-12-12T20:34:13Z (GMT). No. of bitstreams: 1 Dissertacao Paulo em 17-9.pdf: 465544 bytes, checksum: 33b5b1a2b098715556b9cc2171800076 (MD5) Previous issue date: 2007-10-22<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>In order to contribute for the evaluation of the Brazilian policies on generic drugs and their social relevance, this study investigated, by means of a case study on a public health unit, the knowledge that prescribers, dispensers, and users possess on generic drugs and their confidence on those drugs. First, the study investig

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13

Janiaud, Perrine. "The rational use of available evidence before extrapolating the benefit risk ratio from adults to children." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1063/document.

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Les médicaments sont évalués et reçoivent une autorisation de mise sur le marché (AMM) avant d'être prescrits. Ils sont généralement évalués chez des patients adultes, et utilisés chez les enfants en extrapolant les résultats obtenus chez les adultes. L'extrapolation de la balance bénéfice risque de l'adulte à l'enfant intervient lors du développement clinique du médicament et lorsqu'il est prescrit (dans l'AMM ou hors AMM, ce qui est fréquent chez l'enfant). Ceci est dû aux contraintes de la recherche clinique en pédiatrie, qui conduit à un manque de données chez l'enfant. Une recommandation

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14

Minnie, Jacqueline Louise. "An education intervention on prescribing patterns of drugs for acid-related disorders in a clinic setting : a case study / Jacqueline Louise Minnie." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1562.

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15

Dresch, Ana Paula. "Caracterização do nível de conhecimento sobre medicamentos prescritos e prevalência de automedicação por pacientes ambulatoriais odontológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/14316.

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Cirurgiões-dentistas são responsáveis pela prescrição de medicamentos, fazendo-se necessário estudos que investiguem o quanto o paciente conhece seu tratamento. Outro aspecto de destaque na odontologia é a automedicação. OBJETIVOS: Avaliar e caracterizar o nível de conhecimento dos pacientes em relação aos medicamentos prescritos em serviços odontológicos públicos de Porto Alegre; verificar existência de prescrições verbais; identificar a prevalência de automedicação. METODOLOGIA: A pesquisa seguiu o modelo de estudo transversal. O instrumento de coleta de dados foi um questionário preenchido

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16

Mendonça, Alessandra Ésther de. "Estudo das prescrições de antimicrobianos para pacientes idosos hospitalizados sob a perspectiva do uso racional de medicamentos." Universidade Federal de Juiz de Fora (UFJF), 2008. https://repositorio.ufjf.br/jspui/handle/ufjf/2910.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-10-20T17:30:52Z No. of bitstreams: 1 alessandraestherdemendonca.pdf: 404434 bytes, checksum: aba5fda737e161858557304e2a521675 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-10-25T12:29:12Z (GMT) No. of bitstreams: 1 alessandraestherdemendonca.pdf: 404434 bytes, checksum: aba5fda737e161858557304e2a521675 (MD5)<br>Made available in DSpace on 2016-10-25T12:29:12Z (GMT). No. of bitstreams: 1 alessandraestherdemendonca.pdf: 404434 bytes, checksum: aba5fda737e161858557304e2a521675 (MD5)

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Corrêa, Anderson Domingues. "Promoção do ensino sobre o uso racional de medicamentos." reponame:Repositório Institucional da FIOCRUZ, 2012. https://www.arca.fiocruz.br/handle/icict/6947.

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Submitted by Isac Macêdo (isac@ioc.fiocruz.br) on 2013-09-22T01:45:36Z No. of bitstreams: 1 DO 2008 - Anderson Dominguês Corrêa.pdf: 2812522 bytes, checksum: 1449190f80d87130eac09d34edb27e01 (MD5)<br>Made available in DSpace on 2013-09-22T01:45:36Z (GMT). No. of bitstreams: 1 DO 2008 - Anderson Dominguês Corrêa.pdf: 2812522 bytes, checksum: 1449190f80d87130eac09d34edb27e01 (MD5)<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.<br>O uso inadequado de medicamentos constitui uma grande ameaça à saúde pública e pode ter consequências como o atraso no tratamento adeq

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18

Alayadhi, Nadyah Y. A. H. "Establishing an essential medicine list for the State of Kuwait." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/15742.

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The Health Sector at the state of Kuwait is facing many challenges. One of which is public expectations in health are high, and thus, the Ministry of Health (MOH) in Kuwait has amplified the health expenditure by 86% since 2007. And since the medicine budget represents half of the total MOH budget, it is proposed that the development in health policy might be a suitable tool to control the inflation within the health budget. This thesis examines the opportunities and challenges of introducing an EML in Kuwait and the factors influencing its effectiveness. A mixed-methodology approach has been

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19

Carvalho, Felipe Dias. "Avaliação econômica do impacto da atividade de atenção farmacêutica na assistência à saúde: aspectos metodológicos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/17/17139/tde-06032008-160915/.

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A atenção farmacêutica (ATENFAR) é uma nova prática clínica, inerente ao profissional farmacêutico, que tem como principais objetivos a prevenção de doenças, a promoção e a recuperação da saúde de usuários de serviços sanitários, através do fomento ao uso racional de medicamentos. Vários estudos realizados no Brasil e no exterior mostram que a atividade de ATENFAR pode propiciar muitos benefícios aos tratamentos de saúde que fazem uso de farmacoterapia, resultando no aumento da efetividade do tratamento e na melhoria da qualidade de vida dos pacientes. Além disso, alguns estudos mostram que a

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20

Figueiredo, Renata Rodrigues de. "Uso racional de medicamentos na odontologia: conhecimentos, percepções e práticas." Programa de pós-graduação em saúde coletiva, 2009. http://www.repositorio.ufba.br/ri/handle/ri/10293.

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p. 1-108<br>Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-04-23T20:22:20Z No. of bitstreams: 1 33333as.pdf: 519659 bytes, checksum: be3e7a0f9508655ecf7c45122cb44744 (MD5)<br>Approved for entry into archive by Maria Creuza Silva(mariakreuza@yahoo.com.br) on 2013-05-04T16:55:59Z (GMT) No. of bitstreams: 1 33333as.pdf: 519659 bytes, checksum: be3e7a0f9508655ecf7c45122cb44744 (MD5)<br>Made available in DSpace on 2013-05-04T16:55:59Z (GMT). No. of bitstreams: 1 33333as.pdf: 519659 bytes, checksum: be3e7a0f9508655ecf7c45122cb44744 (MD5) Previous issue date: 2009<br>O cirurgião-

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21

Oliveira, Nelyson Dias de. "Estudo da implementação do fracionamento de medicamentos no Brasil : aspectos regulatórios, acesso e uso racional." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/17701.

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O setor farmacêutico brasileiro tem passado por importantes transformações nos últimos anos, entre elas a aprovação da Política Nacional de Medicamentos (PNM), a criação da Agência Nacional de Vigilância Sanitária (Anvisa), a publicação da Lei de Genéricos e a aprovação da Política Nacional de Assistência Farmacêutica (PNAF). Considerando que alguns dos objetivos da PNM são o acesso que propõe disponibilidade equitativa e acessibilidade; a qualidade, segurança e eficácia e o uso racional relativos à medicamentos, é que houve a iniciativa do governo brasileiro em implementar uma estratégia na á

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22

Phiri, Ephraim. "Assessment of the rational use and availability of antimicrobials at primary level health facilities under the Lusaka district community health office, Zambia." University of the Western Cape, 2016. http://hdl.handle.net/11394/5485.

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Magister Public Health - MPH<br>Background: The irrational use of medicines, and increasingly antimicrobials, remains a key health problem in many developing countries including Zambia. Inappropriate, ineffective and inefficient use of medicines is common in health facilities at all levels. There are many factors influencing irrational prescribing and dispensing of antimicrobials including patients, prescribers, dispensers, the supply system (including industry influences), government regulations and medicines information and misinformation. Study aim: The aim of the study was to assess the r

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23

Freire, Renato Antônio Campos. "AVALIAÇÃO DO USO RACIONAL DE ANTIMICROBIANOS PARA MELHORIA DA GESTÃO E MONITORAMENTO DAS INFECÇÕES HOSPITALARES." Pontifícia Universidade Católica de Goiás, 2009. http://localhost:8080/tede/handle/tede/2110.

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Made available in DSpace on 2016-08-10T10:29:32Z (GMT). No. of bitstreams: 1 Renato Antonio Campos Freire.pdf: 19801495 bytes, checksum: 0a96331b0fd8d4a7be741e0abfffb440 (MD5) Previous issue date: 2009-07-27<br>Evaluation of antimicrobials in hospital is complex and multifaceted detail, where the monitoring can contribute greatly to therapeutic efficacy and reduction in hospital costs. The work aims to describe the profile of hospital use of antibiotics in children with restricted use, in an attempt to contribute to reducing costs, improving hospital management and monitoring of hospital inf

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24

Dewulf, Nathalie de Lourdes Souza. "Contribuição da atenção farmacêutica ao tratamento de pacientes com doenças inflamatórias intestinais." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-28072011-151805/.

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As doenças inflamatórias intestinais (DII) - doença de Crohn e retocolite ulcerativa, são condições crônicas que, na maioria dos casos, exigem controle com terapia medicamentosa. A atenção farmacêutica (AF), definida como a provisão responsável do tratamento farmacológico, com o propósito de alcançar resultados concretos que melhorem a qualidade de vida do paciente, constitui nova forma de cuidado ao paciente, que necessita ser mais extensivamente avaliada. Este estudo teve o objetivo de avaliar a contribuição da atenção farmacêutica ao tratamento clínico de pacientes com DII em acompanhamento

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25

Matos, Ana Catarina Lopes Vieira Godinho de. "Uma saúde global : princípios da estratégia global de contenção de resistências a agentes antimicrobianos : sua percepção e implementação pelos produtores de bovinos de carne do Ribatejo Norte." Master's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2011. http://hdl.handle.net/10400.5/3294.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A utilização de antimicrobianos na produção animal tem sido motivo de intenso debate, pelas preocupações sobre possibilidade de transferência de bactérias a eles resistentes dos animais para o Homem. Foram desenvolvidos programas de monitorização de resistências e consumo de antimicrobianos, que demonstram que o desenvolvimento de resistências pode ser minimizado pela implementação de estratégias para uma utilização prudente e racional dos antimicrobianos nas explorações pecuárias. O presente estudo constitui uma primeira abordagem p

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Matveicheva, Kira. "Analýza samoléčení antibiotiky v Kaliningradské oblasti - pilotní studie." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-356023.

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Abtract Charles University Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Title of diploma thesis: The analysis of self-medication with antibiotics in Kaliningrad region - pilote study Student: Kira Matveicheva Supervisor: prof. PharmDr. Jiří Vlček, Ph.D. Consultant: Tatiana Belkina, Ph.D. Objectives: In the theoretical part, I will focus on the self-medication with antibiotics, including its causes and consequences, and the problems associated with the emergence of antibiotic resistance. The aim of the practical part is to analyze the probability and reasons

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27

Timchenko, Natalia. "La dihydrofolate réductase R67, comme une cible d’antibiotiques et biocatalyseur potentiel." Thèse, 2010. http://hdl.handle.net/1866/5196.

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La dihyrofolate réductase de type II R67 (DHFR R67) est une enzyme bactérienne encodée par un plasmide donc aisément transmissible. Elle catalyse la réaction de réduction du dihydrofolate (DHF) en tétrahydrofolate (THFA) essentiel pour la prolifération cellulaire. La DHFR R67 est une enzyme qui dépend du cofacteur NADPH. La DHFR R67 est différente, structurellement et génétiquement, de l’enzyme DHFR chromosomale présente chez tous les organismes et elle est résistante au triméthoprime (TMP) qui est largement utilisé dans les traitements antibactériens chez l’Homme. Aucun inhibiteur sélectif co

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