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Relevant bibliographies by topics / Rational Strain, Metabolic Engineering

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Academic literature on the topic 'Rational Strain, Metabolic Engineering'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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Journal articles on the topic "Rational Strain, Metabolic Engineering"

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Tsouka, Sophia, Meric Ataman, Tuure Hameri, Ljubisa Miskovic, and Vassily Hatzimanikatis. "Constraint-based metabolic control analysis for rational strain engineering." Metabolic Engineering 66 (July 2021): 191–203. http://dx.doi.org/10.1016/j.ymben.2021.03.003.

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Dagariya, Sakshi, Janvi Bhatankar, Tikam Chand Dakal, Bhana Ram Gadi, and Paolo Giudici. "Metabolic and Evolutionary Engineering of Food Yeasts." Processes 13, no. 6 (2025): 1852. https://doi.org/10.3390/pr13061852.

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The yeast metabolic and evolutionary engineering, especially Saccharomyces cerevisiae, plays a significant role in the enhancement of its industrial applications in food, beverage, and biofuel production. This review integrates genetic engineering, systems biology, and evolutionary principles to optimize yeast performance, adaptability, and productivity. The key strategies which enable targeted genome modifications to improve substrate utilization, stress tolerance, and the biosynthesis of valuable metabolites such as flavor compounds, organic acids, vitamins, and antioxidants, including preci

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Freedman, Benjamin G., Parker W. Lee, and Ryan S. Senger. "Engineering the Metabolic Profile of Clostridium cellulolyticum with Genomic DNA Libraries." Fermentation 9, no. 7 (2023): 605. http://dx.doi.org/10.3390/fermentation9070605.

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Clostridium cellulolyticum H10 (ATCC 35319) has the ability to ferment cellulosic substrates into ethanol and weak acids. The growth and alcohol production rates of the wild-type organism are low and, therefore, targets of metabolic engineering. A genomic DNA expression library was produced by a novel application of degenerate oligonucleotide primed PCR (DOP-PCR) and was serially enriched in C. cellulolyticum grown on cellobiose in effort to produce fast-growing and productive strains. The DNA library produced from DOP-PCR contained gene-sized DNA fragments from the C. cellulolyticum genome an

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Burgardt, Arthur, Ludovic Pelosi, Mahmoud Hajj Chehade, Volker F. Wendisch, and Fabien Pierrel. "Rational Engineering of Non-Ubiquinone Containing Corynebacterium glutamicum for Enhanced Coenzyme Q10 Production." Metabolites 12, no. 5 (2022): 428. http://dx.doi.org/10.3390/metabo12050428.

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Coenzyme Q10 (CoQ10) is a lipid-soluble compound with important physiological functions and is sought after in the food and cosmetic industries owing to its antioxidant properties. In our previous proof of concept, we engineered for CoQ10 biosynthesis the industrially relevant Corynebacterium glutamicum, which does not naturally synthesize any CoQ. Here, liquid chromatography–mass spectrometry (LC–MS) analysis identified two metabolic bottlenecks in the CoQ10 production, i.e., low conversion of the intermediate 10-prenylphenol (10P-Ph) to CoQ10 and the accumulation of isoprenologs with prenyl

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Lentsch, Verena, Aurore Woller, Andrea Rocker, et al. "Vaccine-enhanced competition permits rational bacterial strain replacement in the gut." Science 388, no. 6742 (2025): 74–81. https://doi.org/10.1126/science.adp5011.

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Colonization of the intestinal lumen precedes invasive infection for a wide range of enteropathogenic and opportunistic pathogenic bacteria. We show that combining oral vaccination with engineered or selected niche-competitor strains permits pathogen exclusion and strain replacement in the mouse gut lumen. This approach can be applied either prophylactically to prevent invasion of nontyphoidal Salmonella strains, or therapeutically to displace an established Escherichia coli. Both intact adaptive immunity and metabolic niche competition are necessary for efficient vaccine-enhanced competition.

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Gao, Zhenghao, Fengli Wu, Zhidan Zhang, et al. "Improvement of L-Tryptophan Production in Escherichia coli Using Biosensor-Based, High-Throughput Screening and Metabolic Engineering." Fermentation 11, no. 5 (2025): 267. https://doi.org/10.3390/fermentation11050267.

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The demand for L-tryptophan (L-Trp) has been rapidly increasing across various industries, including pharmaceuticals, food, and animal feed. However, traditional production methods have been unable to efficiently meet this growing demand. Hence, this study aimed to develop strategies for enhancing L-Trp production in Escherichia coli. Firstly, an L-Trp-producing strain was selected and subjected to atmospheric and room temperature plasma (ARTP) mutagenesis to generate a mutant library. This was followed by high-throughput screening using an L-Trp-specific riboswitch and a yellow fluorescent pr

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Zhu, Linghuan, Sha Xu, Youran Li, and Guiyang Shi. "Improvement of 2-phenylethanol production in Saccharomyces cerevisiae by evolutionary and rational metabolic engineering." PLOS ONE 16, no. 10 (2021): e0258180. http://dx.doi.org/10.1371/journal.pone.0258180.

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2-Phenylethanol (2-PE) is a valuable aromatic compound with favorable flavors and good properties, resulting in its widespread application in the cosmetic, food and medical industries. In this study, a mutant strain, AD032, was first obtained by adaptive evolution under 2-PE stress. Then, a fusion protein from the Ehrlich pathway, composed of tyrB from Escherichia coli, kdcA from Lactococcus lactis and ADH2 from Saccharomyces cerevisiae, was constructed and expressed. As a result, 3.14 g/L 2-PE was achieved using L-phenylalanine as a precursor. To further increase 2-PE production, L-glutamate

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Nevoigt, Elke. "Progress in Metabolic Engineering of Saccharomyces cerevisiae." Microbiology and Molecular Biology Reviews 72, no. 3 (2008): 379–412. http://dx.doi.org/10.1128/mmbr.00025-07.

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SUMMARY The traditional use of the yeast Saccharomyces cerevisiae in alcoholic fermentation has, over time, resulted in substantial accumulated knowledge concerning genetics, physiology, and biochemistry as well as genetic engineering and fermentation technologies. S. cerevisiae has become a platform organism for developing metabolic engineering strategies, methods, and tools. The current review discusses the relevance of several engineering strategies, such as rational and inverse metabolic engineering, evolutionary engineering, and global transcription machinery engineering, in yeast strain

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Natarajan, Aravind, Thapakorn Jaroentomeechai, Mingji Li, Cameron J. Glasscock, and Matthew P. DeLisa. "Metabolic engineering of glycoprotein biosynthesis in bacteria." Emerging Topics in Life Sciences 2, no. 3 (2018): 419–32. http://dx.doi.org/10.1042/etls20180004.

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The demonstration more than a decade ago that glycoproteins could be produced in Escherichia coli cells equipped with the N-linked protein glycosylation machinery from Campylobacter jejuni opened the door to using simple bacteria for the expression and engineering of complex glycoproteins. Since that time, metabolic engineering has played an increasingly important role in developing and optimizing microbial cell glyco-factories for the production of diverse glycoproteins and other glycoconjugates. It is becoming clear that future progress in creating efficient glycoprotein expression platforms

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Huang, Wei, Yongheng Liu, Xiaomei Ma, Cilang Ma, Yuting Jiang, and Jianyu Su. "Rational Design for the Complete Synthesis of Stevioside in Saccharomyces cerevisiae." Microorganisms 12, no. 6 (2024): 1125. http://dx.doi.org/10.3390/microorganisms12061125.

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Stevioside is a secondary metabolite of diterpenoid glycoside production in plants. It has been used as a natural sweetener in various foods because of its high sweetness and low-calorie content. In this study, we constructed a Saccharomyces cerevisiae strain for the complete synthesis of stevioside using a metabolic engineering strategy. Firstly, the synthesis pathway of steviol was modularly constructed in S. cerevisiae BY4742, and the precursor pathway was strengthened. The yield of steviol was used as an indicator to investigate the expression effect of different sources of diterpene synth

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Dissertations / Theses on the topic "Rational Strain, Metabolic Engineering"

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Rajankar, M. P. "Rational strain design for value added products: a systems metabolic engineering and synthetic biology approach." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5202.

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Rajankar, M. P. "Rational strain design for value added products: a systems metabolic engineering and synthetic biology approach." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5199.

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The grand challenge of metabolic engineering lies in the complexity and redundancy of cellular pathways and the evolutionary drive of a cell to maximize growth rather than a forced bioengineering objective. Engineering microorganisms to thus produce value added products from bulk chemicals as carbon source is now greatly accelerated by use of Synthetic Biology. The fast forwarding evolution has thus uncapped the limits of engineering biological systems. Rational strain design for production of value added products requires channeling of basic substrate molecules towards a desirable metab

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Carere, Robert Carlo. "Genomics of cellulolytic clostridia and development of rational metabolic engineering strategies." MPI Open Access Journals, 2008. http://hdl.handle.net/1993/21707.

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Consolidated bioprocessing, a process in which cellulase production, substrate hydrolysis, and fermentation occur simultaneously, offers the potential for lower biofuel production costs than traditional approaches and is an economically attractive near-term goal for fermentative production of ethanol and/or hydrogen (H2) as biofuels. Current yields fall short of theoretical maxima, vary considerably between species, and are influenced by the highly branched metabolic pathways utilized by fermentative organisms. For fermentative ethanol/ H2 production to become practical, yields must be increas

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Chen, Lin [Verfasser]. "Rational Metabolic Engineering and Systematic Analysis of Escherichia coli for L-Tryptophan Bioproduction / Lin Chen." München : Verlag Dr. Hut, 2017. http://d-nb.info/1128466961/34.

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Schiefelbein, Sarah [Verfasser], and Christoph [Akademischer Betreuer] Wittmann. "Improved L-lysine production in Corynebacterium glutamicum by rational strain engineering / Sarah Schiefelbein ; Betreuer: Christoph Wittmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/112757969X/34.

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Hills, Christopher. "Acetate metabolism in Geobacillus thermoglucosidasius and strain engineering for enhanced bioethanol production." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665397.

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Social, economic and political pressures have driven the development of renewable alternatives to fossil fuels. Biofuels, such as bioethanol, have proved to be successful alternatives. Mature technologies are crop-based, but this has brought criticism due to the conflicting use of land for fuel versus food production. Therefore, bioethanol production technologies have shifted to utilising the sugars that derive from the degradation of lignocellulosic biomass. The thermophilic, Gram-positive bacterium, Geobacillus thermoglucosidasius, can naturally utilise a large fraction of these sugars, and

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Gerebring, Linnéa. "Yeast Saccharomyces cerevisiae strain isolated from lager beer shows tolerance to isobutanol." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-129066.

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The development of biofuels has received much attention due to the global warming and limited resources associated with fossil fuels. Butanol has been identified as a potential option due to its advantages over ethanol, for example higher energy density, compatibility with current infrastructure and its possibility to be blended with gasoline at any ratio. Yeast Saccharomyces cerevisiae can be used as a producer of butanol. However, butanol toxicity to the host limits the yield produced. In this study, four strains of yeast isolated from the habitats of lager beer, ale, wine and baker ́s yeast

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Bi, Changhao. "Metabolic characterization and engineering of Enterobacter asburiae strain JDR-1 to develop microbial biocatalysts for efficient hemicellulose utilization." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0024266.

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Kachel, Benjamin [Verfasser], and Michael [Akademischer Betreuer] Lanzer. "Metabolic engineering of Synechococcus sp. strain PCC 7002 for the photoautotrophic production of riboflavin (vitamin B2) / Benjamin Kachel ; Betreuer: Michael Lanzer." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://nbn-resolving.de/urn:nbn:de:bsz:16-heidok-305364.

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Freedman, Benjamin Gordon. "Degenerate oligonucleotide primed amplification of genomic DNA for combinatorial screening libraries and strain enrichment." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/71346.

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Combinatorial approaches in metabolic engineering can make use of randomized mutations and/or overexpression of randomized DNA fragments. When DNA fragments are obtained from a common genome or metagenome and packaged into the same expression vector, this is referred to as a DNA library. Generating quality DNA libraries that incorporate broad genetic diversity is challenging, despite the availability of published protocols. In response, a novel, efficient, and reproducible technique for creating DNA libraries was created in this research based on whole genome amplification using degenerate oli

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Books on the topic "Rational Strain, Metabolic Engineering"

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Voll, Lars M., and Zoran Nikoloski, eds. Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices. Frontiers Media SA, 2016. http://dx.doi.org/10.3389/978-2-88919-921-1.

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Book chapters on the topic "Rational Strain, Metabolic Engineering"

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Ogbulie, Toochukwu Ekwutosi, Augusta Anuli Nwachukwu, Priscilla Amaka Ogbodo, and Christiana N. Opara. "Strategies for Yeast Strain Improvement through Metabolic Engineering." In Fermentation and Algal Biotechnologies for the Food, Beverage and Other Bioproduct Industries. CRC Press, 2022. http://dx.doi.org/10.1201/9781003178378-7.

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Furusawa, Chikara, Takaaki Horinouchi, Takashi Hirasawa, and Hiroshi Shimizu. "Systems Metabolic Engineering: The Creation of Microbial Cell Factories by Rational Metabolic Design and Evolution." In Advances in Biochemical Engineering/Biotechnology. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/10_2012_137.

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Chibrikin, Danila, Usov Alexey, and Anastasia Lukina. "Investigation of the Stress–Strain State of Wooden Beams with Rational Reinforcement with Composite Materials." In Lecture Notes in Civil Engineering. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-30570-2_16.

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Roshchina, S., A. Gribanov, M. Lukin, D. Chibrikin, and Mei Shunqi. "Investigation of the Stress–Strain State of Wooden Beams with Rational Reinforcement with Composite Materials." In Lecture Notes in Civil Engineering. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-85236-8_42.

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Evangelista, Pedro, Isabel Rocha, Eugénio C. Ferreira, and Miguel Rocha. "Evolutionary Approaches for Strain Optimization Using Dynamic Models under a Metabolic Engineering Perspective." In Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01184-9_13.

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Msanne, Joseph, and Richard D. Ashby. "Genetic and Process Engineering for Select Glycolipid Biosynthesis from Plant/Algal Oils or Their Derivatives." In Green Chemistry and Green Materials from Plant Oils and Natural Acids. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781837671595-00213.

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Microbial glycolipids, composed of fatty acid(s) linked to a carbohydrate moiety, are amphipathic surface-active molecules with numerous applications in the food, textile, and cosmetic industries, as well as in the medical and pharmaceutical industries. Glycolipids play important in vivo structural roles as components of the microbial cell surface or they may be secreted extracellularly into the growth medium. Several microorganisms are emerging as suitable sources for the renewable production of these compounds. In addition, glycolipids can be produced in abundance using inexpensive substrate

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Lee, Sang Yup, Dong-Yup Lee, Tae Yong Kim, Byung Hun Kim, and Sang Jun Lee. "Systems Biotechnology: Combined in Silico and Omics Analyses for the Improvement of Microorganisms for Industrial Applications." In Systems Biology. Oxford University PressNew York, NY, 2006. http://dx.doi.org/10.1093/oso/9780195300802.003.0007.

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Abstract Biotechnology plays an increasingly important role in the healthcare, pharmaceutical, chemical, food, and agricultural industries. Microorganisms have been successfully employed for the production of recombinant proteins [1–4] and various primary and secondary metabolites [5–8]. As in other engineering disciplines, one of the ultimate goals of industrial biotechnology is to develop lower-cost and higher-yield processes. Toward this goal, fermentation and downstream processes have been significantly improved thanks to the effort of biochemical engineers [9]. In addition to the effort o

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Pal, Nirmalya, and Shikha Kapil Soni. "Development of cellulolytic thermotolerant fungal strain." In Genetic and Metabolic Engineering for Improved Biofuel Production from Lignocellulosic Biomass. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-817953-6.00009-9.

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Kaya, Fatma Ece Altinisik, and Fatma Gizem Avci. "Modeling the Microbial Cells for Biotechnological Applications." In Advances in Bioinformatics and Biomedical Engineering. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-6577-6.ch006.

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Synthetic biology is an engineering approach that designs biological systems to have new functions for useful purposes. Rational cell design is crucial for synthetic biology and can be considered a strategy that includes increasing the production efficiency of a cell or developing a new product by changing or adding specific biochemical reactions and regulations using modern metabolic engineering techniques. Metabolic flux and control analyses with models created in silico following cellular genome mapping have also contributed significantly to rational cell design. Models make the prediction

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Sundararaman, Aravind, and Prakash M. Halami. "Metabolic Engineering of Bifidobacterium sp. Using Genome Editing Techniques." In Genome Editing in Bacteria (Part 1). BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815165678124010008.

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The gut microbiome is significant in maintaining human health by facilitating absorption and digestion in the intestine. Probiotics have diverse and significant applications in the health sector, so probiotic strains require an understanding of the genome-level organizations. Probiotics elucidate various functional parameters that control their metabolic functions. Gut dysbiosis leads to inflammatory bowel disease and other neurological disorders. The application of probiotic bacteria to modulate the gut microbiota prevents diseases and has gained large interest. In a recent decade, the develo

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Conference papers on the topic "Rational Strain, Metabolic Engineering"

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Hassani, Leila, Mohammad R. Moosavi, and Payam Setoodeh. "A Graph Based Approach to Analyse Metabolic Networks for Strain Engineering." In 2019 27th Iranian Conference on Electrical Engineering (ICEE). IEEE, 2019. http://dx.doi.org/10.1109/iraniancee.2019.8786434.

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Sribniak, Nataliia, Valerii Lutskovskyi, Liudmyla Tsyhanenko, Serhii Halushka, Hennadii Tsyhanenko, and Stanislav Rohovyi. "Regulation of space grid structure stress-strain state." In 23rd International Scientific Conference Engineering for Rural Development. Latvia University of Life Sciences and Technologies, Faculty of Engineering and Information Technologies, 2024. http://dx.doi.org/10.22616/erdev.2024.23.tf085.

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By analysing publications and research, it is found that space grid structures, which are spatial rod lattice systems, are characterised by their effective static behaviour. The stress-strain state of construction structures, in particular slabs, can be significantly dependent on a number of factors: the shape of the base cell, the way it rests on the supports (walls, columns), the method of arrangement of support posts, and the thickness of the slab. As a conclusion from the research analysis, it can be stated that the research of one of these factors (force regulators), which affects the mat

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Carino, Claudio, Fabio Carli, Carlo Cinquini, and Mauro Gobbi. "Pipe Self-Reinforcing Outlets: Nonlinear Analysis Towards Rational Design." In ASME 1995 Design Engineering Technical Conferences collocated with the ASME 1995 15th International Computers in Engineering Conference and the ASME 1995 9th Annual Engineering Database Symposium. American Society of Mechanical Engineers, 1995. http://dx.doi.org/10.1115/detc1995-0120.

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Abstract A class of self-reinforcing outlets addressed to a wide variety of plants and pipelines is analyzed in this paper in order to examine computer simulation in comparison with bursting tests commonly adopted in industry. Based on a specific pre-processor for mesh generation, finite element analysis is performed on a workstation by a software package suitably accounting for both geometrical and material nonlinearities. Besides stress distribution visualization, high-resolution post-processor capability allows to predict, with sufficient accuracy, plastic strain trend in critical area. Thi

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Nguyen, Ngoc, Olav Fyrileiv, and Chor Yew Chia. "A Numerical Model for Submarine Pipelines With Concrete Coating." In ASME 2017 36th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/omae2017-62440.

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This paper presents a numerical model that is used to estimate the structural response of a submarine pipeline with concrete weight coating subjected to loadings commonly encountered in pipeline installation and operation phases. Findings from parametric studies performed with the numerical model are used to widen the applicable range of the simplified concrete crushing criterion in DNV-OS-F101 (2013) and formulate a rational approach for the design of pipeline concrete weight coating under typical installation and operation conditions. The rational design approach will allow for potential sel

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Nguyen, Ngoc, Olav Fyrileiv, and Chor Yew Chia. "Improving the Installation Criterion for Concrete Coated Pipelines." In ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/omae2018-78512.

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Current design practice limits the concrete strain to approximately 0.2% in a simplified design criterion. In most standard cases, this has proved to be safe and adequate. However, in recent years, the pipeline industry is extending into more remote, harsher environments and larger diameter pipelines. The use of the simplified design criterion has, in some circumstances, resulted in too strict installation requirements which limit the number of relevant installation vessels. This paper presents some findings on the concrete strain for submarine pipelines with concrete weight coating (CWC) deri

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Conway, T. A., P. C. Lam, and N. Mazilu. "On a Theoretical Description of Hysteresis for Soft Tissues." In ASME 1996 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/imece1996-1155.

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Abstract In complex loading conditions, it is important to know, on one hand, the uniaxial behavior of materials and, on the other hand, how this uniaxial behavior changes with the state of material. Soft tissues offer one of the most attractive areas to exercise a mathematical model for the cyclic loading. Particular classes of soft tissues are interesting in that they exhibit a homographic relation between stress and strain, during uniaxial quasistatic experiments [1]. Our investigation of soft tissues behavior shows that this is a consequence of the fact that we can adequately approximate t

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Yang, Zhengmao, Shashi Kumar, and Jens P. Tronskar. "ECA of Pipeline With Girth Weld Strength Mis-Matching Subjected to Large Strain." In ASME 2009 28th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/omae2009-79376.

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In recent years, the strain based design for pipeline has been widely accepted by the industry, but the definition of a rational flaw acceptance criteria for girth welds subjected to axial strain within the context of the existing codified fracture mechanics based assessment procedures is problematic since these are essentially stress based. To extend the FAD method to the large strain conditions, several challenges i.e. weld strength mismatching, fracture toughness, and welding residual stresses have to be understood. With appropriate modifications as per DNV-RP-F108 [1], the assessments proc

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Cheng, Hsien-Chie, Kuo-Ning Chiang, and Chao-Kuang Chen. "Parametric Analysis of Thermally Enhanced BGA Reliability Using a Finite-Volume-Weighted Averaging Technique." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0423.

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Abstract As the eager demand for high power-handling capability in smaller packages, thermally enhanced BGA (TEBGA) packages provide a very attractive solution in improving the poor thermal performance problems of conventional over molded plastic BGA packages. In this study, with solder joint reliability in concern during the initial package design stage, an engineering empirical approach using a finite-volume-weighted averaging technique is applied for characterizing the strain concentration field around the corners of solder joints due to a dramatic geometry/material change. Furthermore, a p

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Zhou, Haofei, Xin Chen, and Yumeng Li. "Design of Gradient Nanotwinned Metal Materials Using Adaptive Gaussian Process Based Surrogate Models." In ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-97659.

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Abstract Inspired by gradient structures in the nature, Gradient Nanostructured (GNS) metals have emerged as a new class of materials with tunable microstructures. GNS metals can exhibit unique combinations of material properties in terms of ultrahigh strength, good tensile ductility and enhanced strain hardening, superior fatigue and wear resistance. However, it is still challenging to fully understand the fundamental gradient structure-property relationship, which hinders the rational design of GNS metals with optimized target properties. In this paper, we developed an adaptive design framew

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Cho, Sang-Rai, Kyeong-Ryun Kim, Seung-Uck Song, Sang-Hyun Park, Joo Sung Lee, and Jin Tae Lee. "Prediction of the Damage Extents of Ship’s Double Hull Side Structures Subjected to Lateral Collisions." In ASME 2016 35th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/omae2016-54605.

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Lateral collision tests were conducted on two steel double-hull side structure models, models DH-3 and DH-4. The models were approximately one-seventh scale of a VLCC (Very Large Crude Carrier), and the small longitudinal stiffeners of a VLCC were smeared into the shell plates. The collision tests were performed using a car crash testing facility. The striker had a knife-edge type header and its mass was 1,350 kg. The collision velocities were 7.224 m/s and 10.0 m/s for models DH-3 and DH-4, respectively. The collision test results are briefly reported in this paper. Using a commercial FEA pac

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