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Dissertations / Theses on the topic 'Rats as laboratory animals'

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Published: 4 June 2021

Last updated: 30 July 2024

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1

Spangenberg, Elin. "Housing laboratory dogs and rats : implications of physical and social activity /." Uppsala : Dept. of Clinical Sciences, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/2007103.pdf.

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2

Wickens, Nicolas John. "Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/4742.

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In this study a standardized 46 week chronic drinking water toxicity protocol was used to elucidate the toxic potential of Sutherlandia frutescens (S. frutescens) using histopathologic, morphometric and transmission electron microscopic analysis. The histopathologic changes in the duodenum, heart, kidney, liver, lung, pancreas and spleen of male Wistar rats were evaluated. Fifty-four rats were randomly divided into four groups: Group 1 – Normal diet control (ND control), n=7, Group 2 – Normal diet + plant extract (ND + p), n=9, Group 3 – High fat diet control (HFD control), n=19Group 4 – High

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3

Bueno, Aline [UNESP]. "Repercussões de diferentes intensidades glicêmicas no início do desenvolvimento embrionário de ratas." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/99239.

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Made available in DSpace on 2014-06-11T19:29:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-02-10Bitstream added on 2014-06-13T18:59:47Z : No. of bitstreams: 1 bueno_a_me_botfm.pdf: 693767 bytes, checksum: 41a33fd1c28d4062c5457b2ea2de4450 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>In vitro studies suggest that maternal hyperglycemia insult impairs the early embryogenesis in the preimplantation period. In this paper, we show that streptozotocin given at birth day of life or in adulthood of rats caused hyperglycemic state. Regardless of hyperglycemic i

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4

Xu, Cen Reith Maarten E. A. "Cocaine and the dopamine transporter." Normal, Ill. Illinois State University, 1996. http://wwwlib.umi.com/cr/ilstu/fullcit?p9721400.

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Thesis (Ph. D.)--Illinois State University, 1996.<br>Title from title page screen, viewed May 30, 2006. Dissertation Committee: Maarten E. A. Reith (chair), Hou Tak Cheung, John W. Dailey, Robert L. Preston, Brian J. Wilkinson. Includes bibliographical references and abstract. Also available in print.

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5

Connolly, Ashley Rex. "Cytokine gene expression in a rat model of polyarthritis /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phc75238.pdf.

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6

Bueno, Aline. "Repercussões de diferentes intensidades glicêmicas no início do desenvolvimento embrionário de ratas /." Botucatu : [s.n.], 2012. http://hdl.handle.net/11449/99239.

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Orientador: Débora Cristina Damasceno<br>Coorientador: Yuri Karen Sinzato<br>Banca: Maria José Sparça Salles<br>Banca: Felipe Perecin<br>Resumo: Não disponível<br>Abstract: In vitro studies suggest that maternal hyperglycemia insult impairs the early embryogenesis in the preimplantation period. In this paper, we show that streptozotocin given at birth day of life or in adulthood of rats caused hyperglycemic state. Regardless of hyperglycemic intensities (mild or severe diabetes), the embryos of these dams presented development retardation and decreased development competence. Apoptosis was det

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7

Vetter, Courtney Suzanne. "Time-course of elevated ethanol intake in adolescent relative to adult rats under continuous, voluntary-access conditions." Diss., Online access via UMI:, 2006.

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8

Hu, Dan. "Brain cytochrome oxidase activity related to vicaroius trial-and-error behavior during Y-maze learning in the rat /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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9

Kong, Hei-man Lowell, and 江希文. "Adrenomedullin: distribution in the male accessory sex glands of the rat and the effects of adrenomedullin inthe seminal fluid on the female reproductive tract." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45605671.

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10

Agnelli, Silvia. "Regulation of amino acid catabolism in rats fed diets with different protein content." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/400005.

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Current lifestyle with high-energy diets and characterized by sedentary is triggering an alarming growth in obesity. Obesity along with metabolic syndrome- related co-morbidities (i.e. insulin resistance, atherosclerosis, sleep apnea, depression, asthma, hypertension and the alteration of blood lipid transport) are the most apparent consequence of the excess energy. Under conditions of excess dietary energy, the body cannot easily dispose of the excess amino-N against the evolutively-adapted schemes that prevent its wastage; thus ammonia and glutamine formation and urea excretion are decreased

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11

Dallison, Agnes, and University of Lethbridge Faculty of Arts and Science. "Mechanisms underlying recovery from early cortical injury in rats." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1999, 1999. http://hdl.handle.net/10133/98.

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Previous work has shown that removal of the midline frontal cortex at seven to ten days of age is followed by recovery of function correlated with apparent spontaneous generation of new tissue in the lesion cavity. The question asked in the present thesis was whether the removal of the regrown tissue in adulthood would block normal function. Rats that received P10 frontal lesions underwent second lesions at P160, and were compared to rats with only P10 or P160 lesions. Rats with P10 + P160 lesions were severely impaired on a spatial learning task, especially relative to the P10 lesion-only rat

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12

Chung, Yee-ling Elaine. "A study on the effects of Angelica Sinensis on gastric ulcer healing in rats." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23295120.

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13

DeClue, Amy E. "Ketamine immunomodulation during endotoxemia." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/6276.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. "August 2007" Includes bibliographical references.

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14

Brunell, Steven Craig. "Pharmacotheraphies for the treatment of alcoholism in adolescents using a rodent model." Diss., Online access via UMI:, 2006.

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15

Gao, Jing, and 高晶. "Effect of acupuncture on the spermatogenesis of heat-treated rodent testis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41291001.

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16

Gao, Jing. "Effect of acupuncture on the spermatogenesis of heat-treated rodent testis." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41291001.

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17

Bonaventura, Leeann R. "Ontogeny of circadian and diurnal rhythms effects of light pulses on ultrasonic vocalizations, locomotor activity and Fos/pCREB expression in the suprachiasmatic nucleus and intergeniculate leaflet of the neonatal rat /." Diss., Online access via UMI:, 2006.

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18

Humm, Jennifer Leigh. "Behavior-dependent neural events and adult neurogenesis : contributions to recovery of motor function after cortical injury /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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19

Volz, Kathryn Ann. "FATIGUE-RELATED CHARACTERISTICS OF THE SOLEUS AND EXTENSOR DIGITORUM LONGUS MUSCLES IN SMALL AND LARGE CAGE-REARED FEMALE RATS." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275378.

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20

Chan, Ying-leung. "Effect of topical green tea on subcutaneous adipocytes in rats." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971519.

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21

Yang, Fu-Chen. "Anatomical and behavioral analysis of SCN lesion and transplantation in neonatal rats." Diss., Online access via UMI:, 2005.

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22

Barnum, Christopher John. "Repeated exposure to restraint but not social defeat leads to habituation of the pituitary-adrenal and stress-herthermic responses." Diss., Online access via UMI:, 2006.

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23

Gao, Jing, and 高晶. "Roles of VAD1.3 in spermatogenesis and fertilization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B4852170X.

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　　Vad1.3 is an evolutionarily-conserved, testis-specific gene identified from a retinol-treated Vitamin A-deficiency (VAD) rat model. VAD1.3 is expressed throughout spermiogenesis at the acrosome of spermatids and epididymal spermatozoa, suggesting a role in acrosome biogenesis or acrosome reaction. The present study aimed to explore the functional role of VAD1.3 in spermatogenesis and sperm functions by the cellular and gene-knockout approaches. 　　Double immunofluorescent microscopy confirmed the co-localization of VAD1.3 and syntaxin 1 in mouse spermatids and spermatozoa. Deletion analysi

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24

Stoodley, Marcus A. "Pathophysiology of Syringomyelia /." Title page, contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phs882.pdf.

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25

Estruel, Amades Seila. "Efectes immunomoduladors de l’exercici físic intens i extenuant i de l’hesperidina en rates." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667434.

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En els darrers anys, la influència de l’exercici físic intens i extenuant ha guanyat molt d’interès, per una banda, pels efectes perjudicials que pot causar tant al sistema immunitari innat com a l’adaptatiu, i per altra banda per l’increment de les persones que participen en competicions esportives d’alt nivell. Tanmateix, s’ha demostrat que una dieta que conté components bioactius, com els polifenols, poden tenir un paper clau en la prevenció o en el retard d’aparició d’aquests efectes negatius. En aquest sentit, l’objectiu principal de la tesi va ser determinar la influència de l’exercici

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26

Escoda, Francolí Jaume. "Efecto de la matriz de beta-fosfato tricálcico con fibronectina en la reparación de defectos óseos críticos: estudio experimental del potencial de regeneración ósea y su aplicabilidad clínica." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667962.

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Estudio experimental, prospectivo y controlado en el que se incluyeron 30 ratas Sprague-Dawley, machos adultos, ex-reproductivos, de 14 semanas de edad y peso entre 250 y 300 g. Los animales se distribuyeron de forma aleatoria a los grupos de estudio mediante una tabla de aleatorización y se recogieron datos en situación basal y a las 6 y 8 semanas de la colocación de los injertos. Se utilizó un defecto de tamaño crítico en la calota craneal de la rata, ya que se trata de un modelo estándar, ventajoso desde el punto de vista económico y adecuado para evaluar la formación ósea en defectos óseos

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27

Al-Kushi, Abdullah Glil. "Pathological changes in mesostriatal neurons in a PKC-gamma mutant rat." Connect to e-thesis, 2007. http://theses.gla.ac.uk/149/.

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Thesis (Ph.D.) - University of Glasgow, 2007.<br>Ph.D. thesis submitted to the Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, 2007. Includes bibliographical references.

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28

Fitch, Thomas E. (Thomas Edward) Carleton University Dissertation Psychology. "The periodicity of chronic cocaine self-administration." Ottawa, 1992.

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29

Li, Zhuoming, and 李卓明. "Heme oxygenase-1 and endothelial dysfunction in the spontaneously hypertensive rat." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48521735.

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The endothelium is important for the regulation of vascular tone. In diseases like hypertension, the endothelial cells become dysfunctional. This dysfunction is characterized by nitric oxide (NO) deficiency, impairment of endothelium-dependent hyperpolarization (EDH) and the overwhelming production of endothelium-derived contracting factor (EDCF). Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, producing carbon monoxide(CO), bilirubin and free iron. Up-regulation of the inducible isoform (HO-1) of the enzyme lowers blood pressure in animals. The purpose of the prese

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30

Gamieldien, Kareemah. "The influence of maternal nicotine exposure on selected glycolytic and cytochrome P450 enzymes in developing neonatal rat lung." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The structural and functional integrity of a developing and maturing fetal and neonatal lung is critically dependent on carbohydrate metabolism. The energy derived from carbohydrate metabolism is utilized during the processed of cell growth and development. It is reported that maternal nicotine exposure during pregnancy and lactation results in the irreversible inhibition of glycolysis, for which no mechanism is currently proposed and a significant increase in glucose turnover. The principal objective of this thesis was to determine the influence of maternal nicotine exposure during gestation

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31

Malago, Rodolfo. "Autotransplante experimental de baço." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311399.

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Orientadores: Nelson Adami Andreollo, Norair Salviano dos Reis<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T12:24:09Z (GMT). No. of bitstreams: 1 Malago_Rodolfo_M.pdf: 3465635 bytes, checksum: 3dc7b9920d1c43468cd3be71172c3771 (MD5) Previous issue date: 2008<br>Resumo: O baço é um órgão linfóide que tem importante papel na defesa dos organismos, participando no processo de filtração, fagocitose e produção de imunoglobulinas. Histologicamente é formado pelo estroma e o parênquima, sendo seu arranjo celula

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32

Dodridge, M. E. "The effects of variable dose methotrexate infusion in the laboratory rat /." Title page, contents and precis only, 1987. http://web4.library.adelaide.edu.au/theses/09DM/09dmd641.pdf.

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33

李蕾 and Lei Li. "Adrenomedullin in female reproductive system: gene expression and actions in cycling and pregnant rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44891799.

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34

Gwayi, Noluzuko. "The effects of melatonin on the testis, epididymis and sperm physiology of the Wistar rat." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1005366.

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Melatonin is a product of the pineal gland and is postulated to play an antigonadotropic role in the reproductive system of mammals. The reproductive system of non-seasonally breeding mammals is believed to be not as responsive to melatonin treatment as that of seasonally breeding mammals. Recently, there has been increasing support from in vivo and in vitro studies, for the hypothesis that melatonin has negative effects on sperm physiology, especially on sperm motility. High and/or low seminal concentrations of melatonin have been associated with abnormalities in human sperm motility and conc

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35

Ng, Kwok-chai Kelvin, and 吳國際. "Local and systemic effects of hepatic radiofrequency ablation in animal models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29434920.

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36

Xiong, Hui, and 熊暉. "Condylar adaptation to active mandibular forward positioning in non-growing rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31374220.

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37

Piette, Etienne. "Scanning electron microscopic studies of the rat mandibular joint : angioarchitecture and surface morphology /." Thesis, Click to view the E-thesis via HKUTO, 1993. http://sunzi.lib.hku.hk/HKUTO/record/B38627978.

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38

Lai, Ka-wai, and 黎嘉慧. "An in vitro study of ovarian folliculogenesis in galactosemic rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B3015134X.

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39

Lacosta, Susan Carleton University Dissertation Psychology. "The effects of MDL 72222, Ketanserin and Methysergide pretreatments on cocaine self-administration in rats." Ottawa, 1992.

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40

Lee, Chun-kei, and 李鎮基. "Development of an in vivo animal model for testing of endodontic medicaments on pulp tissue." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31954182.

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41

Lee, Chun-kei. "Development of an in vivo animal model for testing of endodontic medicaments on pulp tissue." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23300462.

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42

Jornada, Daniela Hartmann. "Efeito da associação da taurina e do 5-fluorouracil em câncer de cólon induzido por DMH. Planejamento e síntese de pró-fármacos derivados /." Araraquara, 2018. http://hdl.handle.net/11449/157230.

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Orientador: Man Chin Chung<br>Coorientador: Cleverton Roberto de Andrade<br>Banca: Luiz Fernando Takase<br>Banca: Cíntia Duarte de Freitas Milagre<br>Banca: Renato Farina Menegon<br>Banca: Jean Leandro dos Santos<br>Resumo: O câncer colorretal (CCR) é um dos 10 tipos de câncer mais incidentes no Brasil. A terapia consiste na remoção cirúrgica e em alguns casos, a quimioterapia adjuvante, composta de 5-fluorouracil e outros fármacos associados. O 5-FU, apesar de amplamente utilizado, provoca uma série de efeitos adversos, relacionados à toxicidade renal, cardíaca, hepática e mucosite. Nesse con

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43

Sham, Ngai-fung. "Study of the protective mechanisms of cigarette smoke and nicotine on experimental ulcerative colitis in rats /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B2342459x.

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44

Rizo, Roca David. "Efectos de la hipoxia hipobárica intermitente en la recuperación del daño muscular inducido por ejercicio excéntrico en ratas entrenadas." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/402828.

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En esta tesis se explora la posibilidad de aplicar la hipoxia hipobárica intermitente (HHI) como herramienta terapéutica no farmacológica para tratar el daño muscular que aparece como consecuencia del ejercicio excéntrico en individuos entrenados. Debido a la necesidad de realizar pruebas invasivas, se escogió un modelo animal. Se entrenaron ratas Sprague-Dawley en un tapete rodante y se sometieron posteriormente a un protocolo de daño muscular inducido por ejercicio excéntrico (EEIMD). Como grupo Control se sacrificó un subgrupo de ratas entrenadas antes del protocolo de EEIMD. El resto de an

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45

Izquierdo, Castro Cristina. "Estudio de terapias antígeno-específicas para la prevención de la diabetes tipo 1 en el ratón nod." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/386436.

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La diabetes tipo 1 (DT1) es una patología autoinmunitaria causada por la destrucción de los islotes β pancreáticos encargados de la producción de insulina. Actualmente, no existe cura alguna para la enfermedad más allá de la administración de insulina exógena a los pacientes, lo cual no permite el control de los efectos nocivos provocados a largo plazo. Por este motivo resulta de relevancia el desarrollo de nuevas terapias que permitan la reversión o prevención de los mecanismos implicados en la dolencia. Dado el papel principal del sistema inmunitario en el avance de la DT1 su modulación resu

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46

Tili, Siphokazi Pamphilia. "Observed pathological changes in male Wistar rats after co-treatment of Type II Diabetes with metformin and sutherlandia frutescens." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1012644.

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Diabetes is a serious condition that affects all the body’s systems including kidneys, heart, eyes and limbs. This alone makes type II diabetes a life threatening disease; an expensive disease and economic burden that many individuals struggle to cope with.The rapid growth type II diabetes in South Africa is associated with the change of life style, and environmental factors brought by westernized way of life living in rural areas. Despite the technical advances in diagnosis and therapy of diabetes many people still use alternative forms of therapy due to the cost, traditional reasons and reli

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47

Chadwick, Wayne. "Observed metabolic changes in male Wistar rats after treatment with an antidepressant implied in undesirable weight gain, or Sutherlandia frutescens for Type II diabetes." Thesis, University of Port Elizabeth, 2003. http://hdl.handle.net/10948/313.

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Type II diabetes is fast becoming a growing problem in developed countries worldwide. Traditionally the median age for diagnosis was around sixty, but recent surveys have shown that the entire age distribution curve has shifted to the left. Western countries boast the worst statistics in which type II diabetes is being reported in children under the age of ten. At such a young age the disease often goes undiagnosed for long periods of time allowing considerable damage to occur. The incidence of type II diabetes is thought to be parallel with the growing rate of obesity associated with a charac

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48

Wong, Shu-hing Louise. "Replicating mesenchymal cells in the glenoid fossa in response to mandibular advancement." Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/hkuto/record/B31973140.

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49

Guilhardi, Paulo. "A unified approach to the study of choice, conditioning, and timing /." View online version; access limited to Brown University users, 2005. http://wwwlib.umi.com/dissertations/fullcit/3174614.

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50

Froc, David John Racine Ronald J. "Neocortical long-term depression and depotentiation in the adult, freely moving rat /." *McMaster only, 2002.

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