Relevant bibliographies by topics / Ray Integral / Dissertations / Theses
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Dissertations / Theses on the topic 'Ray Integral'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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1

GIANNI', SILVIA. "X-ray overview of INTEGRAL Blazars." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1218.

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I quasars Radio Loud (RL) fanno parte di una piccola percentuale (~10%) di Nuclei Galattici Attivi (AGN) e sono caratterizzati da una forte emissione nella banda radio. Lo scopo del nostro lavoro e’ lo studio dell’emissione nella banda dell’X e dell’hard-X di una sotto-classe di questi oggetti: i Blazars. Gli oggetti di tipo Blazar sono AGN aventi un getto di particelle relativistiche (per lo piu’ elettroni e protoni) orientato a piccoli angoli rispetto alla linea di vista. Questa particolare classe di AGN include oggetti di tipo BL Lacerate (BL Lac) e Flat Spectrum Radio Quasar (FSRQ), che si
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2

Pleasants, Ian Blair. "Detector elements for hard X-ray and gamma-ray astronomy applications." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262152.

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3

Clark, David John. "Detection of gamma-ray polarisation using the integral satellite." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494644.

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4

Hill, Adam Ben. "Surveying the gamma-ray sky with the BATSE and INTEGRAL satellites." Thesis, University of Southampton, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434099.

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5

Barlow, Elizabeth Joanne. "Techniques, results & analysis of the INTEGRAL/IBIS soft gamma-ray survey." Thesis, University of Southampton, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434094.

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6

Skokan, Michal. "Regularity of ghosts of geodesic X-ray transform /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5744.

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7

Hoffmann, Agnes Irene Dorothee [Verfasser]. "Analysis of hard X-ray emission from selected very high energy γ-ray [gamma-ray] sources observed with INTEGRAL / vorgelegt von Agnes Irene Dorothee Hoffmann". Reutlingen, Bruno-Matzke-Str.15 : A. Hoffmann, 2009. http://d-nb.info/999640429/34.

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8

Krishnan, Venkateswaran P. "A support theorem and an inversion formula for the geodesic ray transform /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5804.

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9

Johnson, Jedediah Edward Jensen. "Computationally Modeling the Effects of Surface Roughness on Soft X-Ray Multilayer Reflectors." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1626.pdf.

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10

Peille, Philippe. "Développement d'un simulateur pour le X-ray integral field unit : du signal astrophysique à la performance instrumentale." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30236/document.

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Cette thèse est consacrée au développement d'un modèle End-to-End pour le spectrocalorimètre X-IFU qui observera à partir de 2028 l'Univers en rayons X avec une précision jamais atteinte auparavant. Ce travail s'est essentiellement organisé en deux parties. J'ai dans un premier temps étudié la dynamique des parties les plus internes des binaires X de faible masse à l'aide de deux sondes particulières que sont les sursauts X et les oscillations quasi-périodiques au kHz (kHz QPOs). En me basant sur les données d'archive du satellite Rossi X-ray Timing Explorer et sur des méthodes d'analyse spéci
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11

Wunderer, Cornelia B. "Imaging with the test setup for the coded mask INTEGRAL spectrometer SPI performance of a coded aperture [gamma]-ray telescope at 60 keV - 8 MeV /." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967128390.

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12

Cucchetti, Edoardo. "De l'astrophysique des amas de galaxies à la physique des microcalorimètres en rayons X : performances scientifiques et calibration du X-ray integral field unit de la mission Athena." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30162.

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Des découvertes inédites dans le domaine de l'astronomie en rayons X nécessitent une nouvelle génération d'instruments, pouvant observer le ciel en combinant des hautes résolutions spatiales et spectrales. Ce besoin constitue le fondement du X-ray Integral Field Unit (X-IFU) de la mission Athena de l'ESA, dont le lancement est prévu en 2031. La complexité de la chaîne de détection du X-IFU nécessite un suivi de ses perturbations instrumentales. Des simulations bout-à-bout, reproduisant les observations en rayons X de l'émission des photons d'une source représentative à leur détection, sont un
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13

Pesudo, Laure. "Une méthode hybride couplant la méthode des équations intégrales et la méthode des rayons en vue d'applications au contrôle non destructif ultrasonore." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLY009/document.

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Le Contrôle Non Destructif (CND) permet de sonder l’intérieur d’un milieu dans le but desurveiller son intégrité et son vieillissement. Assisté d’outils de simulation il permet de détecter, caractériseret localiser des défauts de structure du milieu inspecté mais sa fiabilité dépend de la précision des méthodesde simulation. Dans le cadre du CND ultrasonore, les méthodes usuelles (numériques et asymptotiques) sontbien souvent inadéquates pour simuler la diffraction par les défauts. On leur préfère des techniques hybrides.On propose dans cette thèse une nouvelle approche hybride pour la simulat
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Pesudo, Laure. "Une méthode hybride couplant la méthode des équations intégrales et la méthode des rayons en vue d'applications au contrôle non destructif ultrasonore." Electronic Thesis or Diss., Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLY009.

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Le Contrôle Non Destructif (CND) permet de sonder l’intérieur d’un milieu dans le but desurveiller son intégrité et son vieillissement. Assisté d’outils de simulation il permet de détecter, caractériseret localiser des défauts de structure du milieu inspecté mais sa fiabilité dépend de la précision des méthodesde simulation. Dans le cadre du CND ultrasonore, les méthodes usuelles (numériques et asymptotiques) sontbien souvent inadéquates pour simuler la diffraction par les défauts. On leur préfère des techniques hybrides.On propose dans cette thèse une nouvelle approche hybride pour la simulat
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15

Barhli, Selim Matthias. "Advanced quantitative analysis of crack fields, observed by 2D and 3D image correlation, volume correlation and diffraction mapping." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:d6240241-8a1e-4a8e-aff0-4a2ef14b0da7.

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This thesis is concerned with the evaluation, in-situ, of the elastic strain energy release rate of cracks. This can define the criteria for crack propagation, and it is usually necessary to obtain this via calculation from the geometry and applied load. A new method is proposed, based on the conjoint use of digital image correlation to measure full-field displacements and finite element to extract the strain energy release rate of surface cracks. It has been extended to 3-D datasets with the use of digital volume correlation and tomographic imaging. A finite element model with imported full-f
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16

Júnior, Felisberto Alves Ferreira. "Medidas das seções de choque térmicas e integrais de ressonância das reações 34S(n,)35S e 42K(n,)43K - Aperfeiçoamento por simulação de Monte Carlo." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/43/43134/tde-13032013-103136/.

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Amostras de nitrato de potássio e enxofre natural foram irradiadas no núcleo do reator de pesquisas IEA-R1 do Instituto de Pesquisas Energéticas e Nucleares, IPEN/CNEN-SP, operando entre 3,5 e 5 MW de potência, para determinar as secções de choque térmicas e integrais de ressonância das reações 34S(n,)35S e 42K(n,)43K. O fluxo de nêutrons foi monitorado com ligas ouro-alumínio. As atividades induzidas nos alvos de ouro-alumínio e nitrato de potássio foram medidas com um detector semicondutor de germânio hiper puro; as atividades dos alvos de enxofre foram determinadas com um sistema de coincid
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17

BARROS, GUSTAVO A. S. J. "Projeto de um laboratorio integrado de calibracao de instrumentos no IPEN." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9372.

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Made available in DSpace on 2014-10-09T12:26:20Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:04:32Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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18

Beckmann, Volker. "Unification of Active Galactic Nuclei at X-rays and soft gamma-rays." Habilitation à diriger des recherches, Université Paris-Diderot - Paris VII, 2010. http://tel.archives-ouvertes.fr/tel-00601042.

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Through the work on X-ray and gamma-ray data of AGN I contributed significantly to the progress in the unification of AGN since I finished my PhD in 2000. <p> The study of the evolutionary behaviour of X-ray selected blazars (Beckmann & Wolter 2001; Beckmann et al. 2002, 2003b; Beckmann 2003) shows that their evolution is not as strongly negative as indicated by previous studies. The overall luminosity function is consistent with no evolution in the 0.1−2.4 keV band as seen by ROSAT/PSPC. There is still a difference compared to the luminosity function of FSRQ and LBL, which seem to show a posi
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19

Silva, Maria Deusa Ferreira da. "Problemas e modelos que contribu?ram com o desenvolvimento do c?lculo diferencial e integral: dos gregos ? Newton." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/14317.

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Made available in DSpace on 2014-12-17T14:36:15Z (GMT). No. of bitstreams: 1 MariaDFS_TESE_1-129.pdf: 4033430 bytes, checksum: adb4bfc3ed31e11090efa86c94de906a (MD5) Previous issue date: 2010-06-25<br>This article refers to a research which tries to historically (re)construct the conceptual development of the Integral and Differential calculus, taking into account its constructing model feature, since the Greeks to Newton. These models were created by the problems that have been proposed by the history and were being modified by the time the new problems were put and the mathematics kn
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20

MARCOLINO, Guilherme Vieira. "Detecção de metais pesados em leite integral cru de vacas criadas no agreste meridional do estado de Pernambuco." Universidade Federal Rural de Pernambuco, 2014. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6828.

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Submitted by Mario BC (mario@bc.ufrpe.br) on 2017-05-03T14:40:37Z No. of bitstreams: 1 Guilherme Vieira Marcolino.pdf: 1140276 bytes, checksum: 2eb6dc4854c5ffda9197f0993976723a (MD5)<br>Made available in DSpace on 2017-05-03T14:40:37Z (GMT). No. of bitstreams: 1 Guilherme Vieira Marcolino.pdf: 1140276 bytes, checksum: 2eb6dc4854c5ffda9197f0993976723a (MD5) Previous issue date: 2014-07-31<br>Milk production is one of the most important Brazilian agribusiness production chains and contemporaneously, there is an increasing demand by increasing productivity, represented by the rise of technologi
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21

González, González Jaret. "PROYECTO PARA EL MANEJO INTEG RAL DE RESIDUOS SÓLIDOS URBANOS, DE MANEJO ESPECIAL Y PELIGROSOS E N SAN MIGUEL ALMAYA, MÉXICO." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2018. http://hdl.handle.net/20.500.11799/94735.

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Contaminación del suelo por lixiviados, dispersión de la Contaminación por el arrastre de los residuos que se depositan a "Cielo Abierto" debido a los procesos del ciclo hidrológico presente en la zona, insalubridad para la población local, pues los residuos incluyen Residuos peligrosos, de Manejo Especial, componentes químicos que tienen la capacidad de generar enfermedades a los habitantes.<br>La forma de manejo de Residuos Sólidos Urbanos en México ha generado impactos negativos al ambiente, San Miguel Almaya es una de Tantas Comunidades del país que experimenta las consecuencias del manej
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22

Ghassoul, M. "Organ preservation with spectral analysis testing based on a microprocessor : Preservation and testing isolated rat heart using a microcomputer on-line analysing the electrocadiogram using integral pulse frequency modulation." Thesis, University of Bradford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374904.

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23

Chang, Hsiu-Ming Samuel. "Interactions between membrane lipids and integral proteins: Effects of bilayer structure on the reconstituted calcium-activated potassium channel from rat brain." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186738.

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The plasma membrane isolates the interior of cells from the external environment. In addition to acting as an insulating barrier, it permits selective interactions across the cell membrane through the presence of membrane-integral proteins which playa major role in the regulation of the internal environment of the cell. One class of membrane-integral proteins forms channels through which solutes pass in and out of the cell. In this dissertation, the properties of one such channel--the high conductance calcium-activated potassium (BK) channel--are examined subsequent to reconstituting the chann
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24

Hendesi, Honey. "CONNECTIVE TISSUE GROWTH FACTOR (CTGF/CCN2) REGULATES OSTEOBLAST CYTOSKELETAL REORGANIZATION AND MOTILITY AND ENHANCES DIFFERENTIATION VIA BINDING TO INTEGRIN RECEPTORS AND ACTIVATION OF DOWNSTREAM SIGNALINGS." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/263674.

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Cell Biology<br>Ph.D.<br>Connective Tissue Growth Factor (CTGF) is a matricellular protein that has been shown to mediate cell adhesion, and as a consequence, it regulates cell proliferation, migration, differentiation and gene transcription. Although previous in vivo and in vitro studies supported the anabolic role of CTGF in skeletogenesis, to date mechanisms of this effect remain unknown. So far, no specific receptor has been identified for CTGF, although previous studies have shown that integrins can serve as functional signaling receptors for CTGF. The CTGF-integrin interaction initiates
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Coelho, Robson Jacinto. "Modelo de simulação operacional do manuseio de matérias-primas de uma usina siderúrgica integrada." Universidade Federal da Paraí­ba, 2011. http://tede.biblioteca.ufpb.br:8080/handle/tede/5196.

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Made available in DSpace on 2015-05-08T14:53:17Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 3747541 bytes, checksum: 321b5f29863e2f68953902273ae4cb9f (MD5) Previous issue date: 2011-08-15<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The main goal of this dissertation is to design and implementation of an Operational Simulation Model (OSM) of the handling of raw material in an Integrated Steelmaking Plant, considering operations of receiving, unloading, stocking, handling and supplying the different raw materials related to the production process with an operational pe
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Chakraborty, Arup Ratan. "Differential Expression of Integrin α3β1 and α6β4 Molecules on a Panel of Rat Esophageal Cell Lines". Bowling Green State University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1131345357.

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27

Nasertorabi, Fariborz. "Biochemical and Structural Studies on the Adaptor Protein p130Cas." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4777.

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28

Fedyszyn, Tomáš. "Finanční analýza podniku v kontextu procesu evropské ekonomické integrace." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-77824.

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There is a relation between financial analysis of a company and the economic and legal environment of its registered place of business. The financial analysis is based on the financial reports reflecting the requirements of the national or supranational system of financial accounting. The creation of the single internal market of the European Union leads to harmonization of the financial accounting and reporting of the individual member states. The companies residing in the Czech Republic are obliged to make out the annual closure of accounts in compliance with the Czech Accounting Standards t
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Šimon, Vojtěch. "Spolehlivost pájených spojů LED panelů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-319627.

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Thesis is focused on the effect of heating factor on quality of solder joints. In theoretical part is solved reflow soldering technology, problematice of solder paste choice or criteria of soldering profile setting. The practical part is dedicated to demonstrating the impact of heating factor on solder joint quality. There are used X-Ray analysis, microsections and electron microscopy. In the final part of this thesis are summarized knowledge from theoretical part and experimental obtained results to defend of next steps in diploma thesis.
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Mao, Xianqing. "Effets des contraintes mécaniques cycliques sur la génération de thrombine à la surface des cellules musculaires lisses de rat." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0003/document.

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Les cellules musculaires lisses (CML) vasculaires les composants cellulaires principaux de la paroi artérielle, sont exposées constamment aux contraintes mécaniques. Les contraintes mécaniques cycliques régulent de nombreuses fonctions des CML vasculaires via les intégrines. Parmi les intégrines, l'[alpha]v[gamma]3 est non seulement un mécano-transducteur mais aussi le récepteur de la prothrombine à la surface des CML. L?activation de l'intégrine [alpha]v[gamma]3 par les contraintes mécaniques pourrait favoriser l'adhésion des CML à la prothrombine et aussi accélérer la génération de thrombine
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31

Ballandras, Allison. "Étude cristallographique du domaine catalytique de l’intégrase du virus RAV-1 (rous associated virus type 1) et découverte d’une nouvelle interface de dimérisation." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10251/document.

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Au cours du cycle réplicatif des rétrovirus, l’ADN viral rétro-transcrit est intégré dans l’ADN de la cellule hôte par l’intégrase virale (IN). L’IN possède un rôle clé dans le cycle rétroviral et représente une cible thérapeutique majeure pour le traitement des infections par le virus de l’immunodéficience humaine (VIH). L’IN est constituée de trois domaines (N-terminal, central et C-terminal) connectés par des boucles flexibles, qui la rendent difficilement cristallisable. Le Dr. C. Ronfort (Equipe Rétrovirus et Intégration Rétrovirale) et le Pr. P. Gouet (Laboratoire de BioCristallographie)
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Junior, Barnabé da Silva. "Avaliação da atratividade de negócios em geração distribuída e economia de energia elétrica: piloto aplicado dentro dos estudos de PIR na RAA." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/3/3143/tde-12062013-145735/.

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O objetivo da dissertação foi o desenvolvimento de um modelo de avaliação rápida da atratividade de oportunidades de negócios em recursos energéticos renováveis dentro de uma região geográfica delimitada, valendo-se dos resultados do Planejamento Integrado de Recursos Energéticos (PIR) para a região analisada, complementado com outras bases bibliográficas primárias e secundárias. O uso dos resultados do PIR propiciou o acesso rápido a avaliações prontas dos recursos energéticos em três dimensões1, além da dimensão técnico-econômica, incluindo opiniões e posições da sociedade local e nacional (
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TISATO, Flavia. "Study on Modern and Contemporary works of Art through non invasive integrated physical techniques." Doctoral thesis, Università degli studi di Ferrara, 2014. http://hdl.handle.net/11392/2388948.

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During my PhD I developed two parallel and complementary topics, concerning both works of art and materials. The first one, focused on non-invasive investigations on works of art (ancient and contemporary), was aimed to deepen conservative state, material composition, painting techniques and the early detection of any deterioration. This latter goal also guided the study of pictorial and restoration materials, mainly aimed at their characterization from the optical point of view. Diagnostic activities made use of different methods of investigation. Among image techniques, photography and macr
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Dayal, Shubham. "Novel Roles of RNase L in Prostate Cancer." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1492793747213566.

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López, Muñoz Laura. "Homology modeling and structural analysis of the antipsychotic drugs receptorome." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7228.

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Classically it was assumed that the compounds with therapeutic effect exert their action interacting with a single receptor. Nowadays it is widely recognized that the pharmacological effect of most drugs is more complex and involves a set of receptors, some associated to their positive effects and some others to the side effects and toxicity. Antipsychotic drugs are an example of effective compounds characterized by a complex pharmacological profile binding to several receptors (mainly G protein-coupled-receptors, GPCR). In this work we will present a detailed study of known antipsychotic drug
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Wunderer, Cornelia B. [Verfasser]. "Imaging with the test setup for the coded mask INTEGRAL spectrometer SPI : performance of a coded aperture γ-ray telescope at 60 keV - 8 MeV / Cornelia B. Wunderer". 2003. http://d-nb.info/967128390/34.

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37

Penney, Jonathan. "A Photon Mapping Based Approach to Computing Celestial Illumination." 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-470.

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For photographers to capture good pictures of their subjects, the lighting conditions must be taken into account and adjusted for accordingly. The same holds true for a satellite attempting to photograph another object in space: it must know the lighting conditions to adjust camera settings and position itself properly to take the best photograph. This thesis presents a photon mapping based algorithm to compute a physically accurate representation of the illumination of objects in orbit around the Earth, taking into account the effects that cause refraction in the atmosphere. I also discuss th
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Lopes, José Domingos Limpo Trigueiros Monteiro Lopes. "OS MEIOS DE RAL: UMA ALTERNATIVA INTEGRADA." Master's thesis, 2018. http://hdl.handle.net/11110/1515.

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A sociedade mudou, evoluiu, devido principalmente à grande revolução tecnológica ocorrida no último século. Com esta evolução verificou-se no nosso ordenamento jurídico um aumento exponencial da litigância, ao qual os meios tradicionais de justiça, sobejamente, os tribunais, não conseguiram dar resposta, tendo-se gerado uma grave crise na Justiça, e um descrédito generalizado por parte da sociedade civil nos tribunais. No sentido de dar resposta a esta necessidade de resolver a crise na Justiça, o legislador procedeu à criação e desenvolvimento de meios extrajudiciais que permitisse retirar pr
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Kumari, Shylaja J. "Studies on the whole atom integral incoherent scattering cross sections for gamma rays." Thesis, 1994. http://hdl.handle.net/2009/1399.

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Venturi, Giacomo. "The impact of galactic outflows on their host galaxies through spatially resolved spectroscopy." Doctoral thesis, 2019. http://hdl.handle.net/2158/1160629.

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The observed properties of galaxies and supermassive black holes (BH) at their centers suggest that there must be a non-gravitational feedback mechanism regulating their evolution. These are the discrepancy at low and high masses between the observed stellar mass function of galaxies and that predicted by ΛCDM models, the scaling relations between the mass of BHs and the velocity dispersion, mass and luminosity of the host galaxy spheroid and the similarity between BH growth and star formation cosmic histories. Models of galaxy formation and evolution in fact routinely include feedback from ac
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Almeida, Mário Rui Dias. "Synthesis of 5-aryl-imidazo [2,1-b] thiazole compounds possibly RAF kinase inhibitors." Master's thesis, 2014. http://hdl.handle.net/10451/38753.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Malignant melanoma is the most aggressive type of skin cancer because of its high tendency to metastasize. In fact, the mortality rate from malignant melanoma has risen about 2% annually since 1960. Malignant melanoma occupies the 19th place as the most common cancer worldwide. In Portugal, according to the Portuguese League Against Cancer are nearly 700 new cases of melanoma annually and the incidence rate reaches 6-8 cases per 100000 individuals. These data are similar to Sou
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Lopes, João Pedro Alves. "Age dependency of Escherichia coli K1 systemic infection in the neonatal rat." Master's thesis, 2013. http://hdl.handle.net/10451/29551.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Background: Escherichia coli (E. coli) K1 is responsible for about 85% of cases of E. coli neonatal bacterial sepsis and meningitis. E. coli K1 strains are vertically transmitted from mother to child during birth. E. coli O18:K1 A192PP, the strain used in this study, demonstrated to have age dependent disease severity and to be fatal when administrated to 2-day-old animals. The knowledge of the E. coli K1 distribution trends numbers along the different regions of the small intes
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Moura, Carlota Madeira da Silva. "Perfil da notificação espontânea de suspeitas de reações adversas associadas à Varfarina na região Sul de Portugal, no período de 2011 a 2015. Reflexões após 50 anos de mercado em Portugal." Master's thesis, 2016. http://hdl.handle.net/10451/35792.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Introdução Em Portugal, é a Direção de Gestão do Risco do Medicamento em estreita relação com as Unidades Regionais de Farmacovigilância, que monitoriza a segurança dos medicamentos com autorização de introdução no mercado nacional, avaliando os eventuais problemas relacionados com RAM, principalmente através da análise de notificações espontâneas. No âmbito da informação recolhida no avaliar das notificações espontâneas recebidas na Unidade de Farmacovigilância do Sul nos últ
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Henriques, Marta Alexandra Lavrador. "Perfil da notificação espontânea de suspeitas de reações adversas associadas a Vacinas na região Sul de Portugal, no período de 2011 a 2015." Master's thesis, 2016. http://hdl.handle.net/10451/35884.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Introdução As vacinas são preparações biológicas que conferem imunidade relativamente a uma doença em particular. Apesar de serem consideradas efetivas e seguras não são isentas de risco, podendo ocorrer reações adversas após vacinação. Neste sentido torna-se necessário monitorizar a incidência de reações adversas associadas a vacinas. A monitorização da segurança das vacinas é objeto de estudo da Farmacovigilância, em particular através da análise e caracterização do perfil de
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Alves, Maria Carolina Cecílio de Sousa Botão. "Analysis of nucleic acids from medicinal plants from Lamiaceae." Master's thesis, 2016. http://hdl.handle.net/10451/35876.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>A família das Lamiaceae, Perovskia abrotanoides e Perovskia atriplicifolia em particular, tem especial interesse devido às suas propriedades medicinais. No entanto, este potencial ainda não é completamente compreendido. Os seus óleos essenciais e os seus fenilpropanoides são a razão destas propriedades. O ácido rosmarínico é realçado neste trabalho devido ao seu contributo em relação às propriedades medicinais no género Perovskia, uma vez que é, por exemplo, anti-inflamatório e
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Hendrych, Lukáš. "Role Evropské rady v prelegislativní fázi evropského legislativního procesu." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-398798.

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The aim of the master thesis "The role of the European Council in the pre-legislative phase of the European legislative process" is to analyse position and influence of the European Council before proposing an official legislative proposal by the European Commission in the EU's legislative process. This pre-legislative phase of a designing of a European legislation is important, though informal. The aim of this master thesis it to find out how strong is the European Council in an agenda setting when it comes to a European legislation and to what extent the Commission is inspired or follows the
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Zhu, Wenying. "Regulation of sphingosine kinase 1 oncogenic signalling by calcium and integrin binding proteins." Thesis, 2017. http://hdl.handle.net/2440/126465.

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Sphingosine kinase 1 (SK1) is one of the key enzymes that regulate the cellular balance of pro-apoptotic and pro-survival sphingolipids. By catalysing formation of the versatile signalling molecule sphingosine 1-phosphate (S1P), SK1 has clear roles in a wide range of cellular processes. The dysregulation of SK1 signalling has been broadly implicated in the pathogenesis of various cancer types, although better understanding of the regulation of SK1 and how defects in this exerts oncogenic effects is still required. Previously, studies by the Pitson Laboratory found that oncogenic signalling of
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Luis, Ângelo Miguel Nunes. "Quality by Design: como reduzir as Infeções Associadas aos Cuidados de Saúde (IACS) e a Resistência aos Antimicrobianos (RAM)." Master's thesis, 2016. http://hdl.handle.net/10451/35785.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Escolhi o tema “Quality by Design” para a elaboração da minha tese, dado que é um termo amplamente usado em inúmeras áreas e com resultados muito positivos. Infelizmente, a sua associação com os sistemas de saúde não é muito pensada, sobretudo em Portugal, e mesmo quando são elaborados procedimentos e normas que permitem a melhoria contínua dos cuidados de saúde, estes muitas vezes não são seguidos, seja devido às pessoas ou às estruturas que não estão preparadas para suportar e
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Blanchon, Daphné Stéphanie Victoria. "Effects of paracetamol-induced acute liver failure on the expression of connexin 43 and Pannexin 1 in primary rat hepatocytes." Master's thesis, 2014. http://hdl.handle.net/10451/39278.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Connexin and pannexin proteins provide communication between cells and the extracellular space as part of gap junctions and hemichannels. Through paracrine signaling or direct intercellular coupling these proteins ensure tissue homeostasis, which requires a dynamic balance between cell proliferation, differentiation and cell death. The liver was among the first organs in which connexin proteins were identified and Pannexin 1 hemichannels are held as key players in the regulation
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ANGULO, GARCIA DAVID. "Biological relevance of spiking neural networks." Doctoral thesis, 2016. http://hdl.handle.net/2158/1043636.

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Throughout this dissertation I examine the α-pulse coupled Leaky Integrate and Fire network as a relevant model accounting for biological observations in the neuroscience’s field. In doing so, I study in detail the role of the structural properties (parameters) of the α-LIF model in shaping the dynamics in three experimentally inspired applications: First I provide a theoretical substrate to understand the role of sparse connectivity in generating non-trivial dynamics in excitatory networks, akin to the Giant Depolarizing Potentials (GDP) in developing hyppocampal networks. I then analyze the
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