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Journal articles on the topic 'RC Internal medicine'
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1
Li, Ho-ming, Jackie YM Chau, SB Woo, J. Lai, and WL Chan. "Chinese version of the Rotator Cuff Quality of Life questionnaire: Cross-cultural adaptation and validation in rotator cuff-impaired patients in Hong Kong." Journal of Orthopaedics, Trauma and Rehabilitation 27, no. 1 (October 15, 2019): 23–27. http://dx.doi.org/10.1177/2210491719878877.
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Purpose: To adapt the Rotator Cuff Quality of Life (RC-QOL) questionnaire into traditional Chinese (Chi-RC-QOL) and to evaluate the validity and reliability in patients suffering from rotator cuff pathologies in Hong Kong. Methods: The Chi-RC-QOL will be constructed using the forward-translation followed by the backward-translation method. Thirty consecutive patients with clinically and radiologically confirmed rotator cuff pathology were recruited. Descriptive statistics will be followed by validity assessment using comparison with the Constant Shoulder (CS) score, University of California Los Angeles (UCLA) Shoulder Rating Scale, and Western Ontario Rotator Cuff (WORC) score. Parametric data will be tested using Pearson’s correlation coefficient for the total scores. Reliability was assessed using a test–retest interval of 30 min. The Cronbach’s α and intraclass correlation coefficient were calculated. Results: Cronbach’s α and internal consistency scores were high for all parts of the Chi-RC-QOL, with Cronbach’s α ranging between 0.89 and 0.98. Internal consistency scores range from 0.82 to 0.92, which can be regarded as an excellent correlation. Test–retest reliability was excellent for all parts of the Chi-RC-QOL with good absolute reliability. Chi-RC-QOL correlates well with the CS score, UCLA Shoulder Rating Scale, and the WORC score, with all being statistically significant. Conclusions: The current study adapted the RC-QOL to traditional Chinese version. The analysis confirmed the validity and reliability of the Chi-RC-QOL questionnaire. Level of Evidence: III.
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Milovancevic, Milos. "Shear strength of fibre reinforced polymers (FRP) used as internal reinforcement for reinforced concrete (RC) beams." Facta universitatis - series: Architecture and Civil Engineering 19, no. 2 (2021): 207–18. http://dx.doi.org/10.2298/fuace210909016m.
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The main aim of the study was to perform selection procedure in order to find the optimal predictors for the shear strength of fibre reinforced polymers (FRP) used as internal reinforcement for reinforced concrete (RC) beams. The procedure was performed by adaptive neuro fuzzy inference system (ANFIS) and all available parameters are included. The ANFIS model could be used as simplification of the shear strength analysis of the FRP-RC beams. MATLAB software was used for the ANFIS application for the shear strength prediction of the FRP-RC beams. The results from the searching procedure indicated that ?beam width? and ?effective depth? form the optimal combination of two input attributes or two predictors for the shear strength prediction of the FRP-RC beams. This selected two predictors could be used effectively to estimate the strength of the FRP-RC beams.
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Juan Fernando Ordoñéz-Aguilera, Rafael Massunari Maenosono, Denise Ferracioli Oda, Heitor Marques Honório, Rafael Francisco Lia Mondelli, and Sérgio Kiyoshi Ishikiriama. "Sealing ability of materials used as protective cervical barrier in internal tooth bleaching." RSBO 14, no. 2 (June 29, 2017): 67–73. http://dx.doi.org/10.21726/rsbo.v14i2.641.
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The use of a protective cervical barrier (PCB) is very well established to perform a safe internal bleaching; however, there is still no consensus on which material has the best sealing ability. Objective: This in vitro study aimed to evaluate the apical and linear sealing of different PCB materials placed during internal bleaching. Material and methods: This study had two study factors: PCB positioning, divided at two levels (cement-enamel junction [CEJ] and 1mm above the cement enamel junction [CEJ+1]); and PCB material, divided at eight levels (resin composite [RC], glass ionomer cement [GIC], resin-modified glass ionomer cement liner [LRGIC], restorative resin-modified glass ionomer cement [RRGIC], zinc phosphate cement [ZPC], eugenol-free zinc oxide cement [ZOC], provisional filling resin [PFR] and gutta-percha as control [GUT]). Response variables were apical and linear sealing obtained through dye penetration and analyzed with a digital microscope. Data were subjected to two-way analysis of variance followed by Tukey test (p<0.05). Results: The main factor for both apical and linear sealing was the type of material (p<0.01) regardless of their position. RC and ZPC presented the worst sealing values (p<0.05). The Spearman rank correlation coefficient revealed a positive correlation between the apical and linear leakage. Conclusion: The results suggest that RC and ZPC must be avoided as a PCB during internal bleaching procedures.
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Catto, James W. F., Pramit Khetrapal, Gareth Ambler, Rachael Sarpong, Muhammad Shamim Khan, Melanie Tan, Andrew Feber, et al. "Robot-assisted radical cystectomy with intracorporeal urinary diversion versus open radical cystectomy (iROC): protocol for a randomised controlled trial with internal feasibility study." BMJ Open 8, no. 8 (August 2018): e020500. http://dx.doi.org/10.1136/bmjopen-2017-020500.
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IntroductionBladder cancer (BC) is a common malignancy and one of the most expensive to manage. Radical cystectomy (RC) with pelvic lymphadenectomy is a gold standard treatment for high-risk BC. Reductions in morbidity and mortality from RC may be achieved through robot-assisted RC (RARC). Prospective comparisons between open RC (ORC) and RARC have been limited by sample size, use of extracorporeal reconstruction and use of outcomes important for ORC. Conversely, while RARC is gaining in popularity, there is little evidence to suggest it is superior to ORC. We are undertaking a prospective randomised controlled trial (RCT) to compare RARC with intracorporeal reconstruction (iRARC) and ORC using multimodal outcomes to explore qualitative and quantitative recovery after surgery.Methods and analysisiROC is a multicentre prospective RCT in English National Health Service (NHS) cancer centres. We will randomise 320 patients undergoing RC to either iRARC or ORC. Treatment allocation will occur after trial entry and consent. The primary outcome is days alive and out of hospital within the first 90 days from surgery. Secondary outcomes will measure functional recovery (activity trackers, chair-to-stand tests and health related quality of life (HRQOL) questionnaires), morbidity (complications and readmissions), cost-effectiveness (using EuroQol-5 Domain-5 levels (EQ-5D-5L) and unit costs) and surgeon fatigue. Patients will be analysed according to intention to treat. The primary outcome will be transformed and analysed using regression. All statistical assumptions will be investigated. Secondary outcomes will be analysed using appropriate regression methods. An internal feasibility study of the first 30 patients will evaluate recruitment rates, acceptance of randomised treatment choice, compliance outcome collection and to revise our sample size.Ethics and disseminationThe study has ethical approval (REC reference 16/NE/0418). Findings will be made available to patients, clinicians, funders and the NHS through peer-reviewed publications, social media and patient support groups.Trial registration numbersISRCTN13680280andNCT03049410.
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Diaconu, Camelia Cristina, Maria Manea, Mihaela Adela Iancu, Ana Maria Alexandra Stanescu, Bogdan Socea, Dan Arsenie Spinu, Dragos Marcu, and Ovidiu Gabriel Bratu. "Hyponatremia in Patients with Heart Failure: a Prognostic Marker." Revista de Chimie 69, no. 5 (June 15, 2018): 1071–74. http://dx.doi.org/10.37358/rc.18.5.6263.
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Due to the high prevalence of cardiovascular diseases and better treatment strategies, with increased survival, heart failure is a condition with increasing prevalence, especially in developed countries. Heart failure patients often present electrolytic disorders, the most frequent one being hyponatremia. The objective of the study was to evaluate the frequency of hyponatremia in patients with chronic heart failure hospitalized in the Internal Medicine Clinic of the Clinical Emergency Hospital of Bucharest and to assess the clinical and paraclinical correlations, as well as prognostic implications of hyponatremia in these patients. We performed an observational retrospective study on 400 chronic heart failure patients hospitalized between January 1st 2014 and August 31st 2015. From these patients, 60 patients have been diagnosed with hyponatremia (defined as a serum natrium [135 mEq/L) and represented our group of study. The values of the serum natrium at admission in the study group ranged between 110-132 mmol/L. Most patients had advanced heart failure, according to NYHA classes� classification. The proportion of patients discharged with persistent hyponatremia was 48.33%, lower than the patients discharged with corrected serum sodium (51.67%), indicating an effective treatment of hyponatremia during hospitalization. The mortality rate during hospitalization in patients with corrected hyponatremia was 8.33%, smaller than the mortality rate in patients with persistent hyponatremia despite the correct administration of hydroelectrolytic rebalancing treatment (18.33%). Persistent hyponatremia may be considered a marker of a poor prognosis in hospitalized heart failure patients.
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Xu, Mingyuan, Weifeng Huang, Min Xu, Jinping Lei, and Hongming Chen. "3D Conformational Generative Models for Biological Structures Using Graph Information-Embedded Relative Coordinates." Molecules 28, no. 1 (December 31, 2022): 321. http://dx.doi.org/10.3390/molecules28010321.
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Developing molecular generative models for directly generating 3D conformation has recently become a hot research area. Here, an autoencoder based generative model was proposed for molecular conformation generation. A unique feature of our method is that the graph information embedded relative coordinate (GIE-RC), satisfying translation and rotation invariance, was proposed as a novel way for encoding molecular three-dimensional structure. Compared with commonly used Cartesian coordinate and internal coordinate, GIE-RC is less sensitive on errors when decoding latent variables to 3D coordinates. By using this method, a complex 3D generation task can be turned into a graph node feature generation problem. Examples were shown that the GIE-RC based autoencoder model can be used for both ligand and peptide conformation generation. Additionally, this model was used as an efficient conformation sampling method to augment conformation data needed in the construction of neural network-based force field.
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Falagario, Ugo Giovanni, Gian Maria Busetto, Marco Recchia, Edoardo Tocci, Oscar Selvaggio, Antonella Ninivaggi, Paola Milillo, et al. "Foggia Prostate Cancer Risk Calculator 2.0: A Novel Risk Calculator including MRI and Bladder Outlet Obstruction Parameters to Reduce Unnecessary Biopsies." International Journal of Molecular Sciences 24, no. 3 (January 26, 2023): 2449. http://dx.doi.org/10.3390/ijms24032449.
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Risk calculator (RC) combining PSA with other clinical information can help to better select patients at risk of prostate cancer (PCa) for prostate biopsy. The present study aimed to develop a new Pca RC, including MRI and bladder outlet obstruction parameters (BOOP). The ability of these parameters in predicting PCa and clinically significant PCa (csPCa: ISUP GG≥2) was assessed by binary logistic regression. A total of 728 patients were included from two institutions. Of these, 395 (54.3%) had negative biopsies and 161 (22.11%) and 172 (23.6%) had a diagnosis of ISUP GG1 PCa and csPCa. The two RC ultimately included age, PSA, DRE, prostate volume (pVol), post-voided residual urinary volume (PVR), and PIRADS score. Regarding BOOP, higher prostate volumes (csPCa: OR 0.98, CI 0.97,0.99) and PVR ≥ 50 mL (csPCa: OR 0.27, CI 0.15,0.47) were protective factors for the diagnosis of any PCa and csPCa. AUCs after internal validation were 0.78 (0.75, 0.82) and 0.82 (0.79, 0.86), respectively. Finally, decision curves analysis demonstrated higher benefit compared to the first-generation calculator and MRI alone. These novel RC based on MRI and BOOP may help to better select patient for prostate biopsy after prostate MRI.
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Sabah, Hadeel A. H., and Ibrahim S. I. Harba. "A Review-Behavior of Reinforced Concrete Exterior Beam-Column Connections under Cyclic Loading." E3S Web of Conferences 318 (2021): 03008. http://dx.doi.org/10.1051/e3sconf/202131803008.
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In many seismically active regions worldwide, massive reinforced concrete (RC) structures built before the 1970s existed. These older RC buildings, in countries having seismic history, were designed for gravity loads only. Anyway, the beam-column connections influence the structures where the functions of connection shortage by transport the forces like shear, moment, and torsion through the beam to the column. Also, it could behave in a ductile manner to help the structure resist the seismic, as simulate the seismic loading by high and low cyclic loading. Due to the failure of external joints more than the internal beam-column joints, this review focuses on the behavior of exterior beam-column joints under cyclic loading, consequently simulated the behavior under an earthquake and the reinforcement detailed.
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Caraiane, Aureliana, Andreea Szalontay, Luana Andreea Macovei, Aurelia Romila, Lucian Laurentiu Indrei, Mioara Decusara, and Tiberiu Tarc. "Oral-Facial Manifestations Caused by the Use of Psychotropic Medication in Psychiatric Patients." Revista de Chimie 69, no. 6 (July 15, 2018): 1581–84. http://dx.doi.org/10.37358/rc.18.6.6374.
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The development of psychotropic chemotherapy with widespread use in the psychiatric clinic for its anxiolytic, hypnotic, antidepressant, psychostimulant or psycho-destructive sedative effects has given rise to a new pathology secondary to increased abuse and accessibility. Their neurotropism is generally exerted on the central nervous system at the level of the complex meso-diencephalo-striate structures, influencing the elementary psychic functions, but also the activity of the whole organism through the neuro-humoral system. The clinical investigation of the patient must be interdisciplinary in nature, as human beings are characterized by a bio-psycho-social unit, in which the various biological and psychological components, influenced to a greater or lesser extent by the social environment, are involved in a special way, which gives an original personality to everyone. There are five fundamental axes, which are usually evaluated: thinking, memory, attention, emotion and behavior. A disorder in any of these axes, intense enough to interrupt the normal activity in more than one operating field over a sufficiently long period of time, is diagnosable as a mental disorder. There is an indication borrowed from internal medicine regarding the acute character (weeks), subacute character (months) and chronic character (years), which is attached to the diagnosis. A small part of the entire psychiatric population suffers from severe conditions, which involve intermittent episodes of severe disinhibition, aggressive behavior and self- or hetero-directed violence. In most cases, we talk about conditions such as depression or anxiety disorders (panic disorder, phobias, obsessive-compulsive disorder), which do not make him a social predator, although they cause enormous suffering to the individual. This study includes 67 patients with mental illness. While conducting the study, we took into account that the first contact with the patient is essential for the results of the anamnesis, oral examination, risk assessment and provisional treatment plan. In the 67 cases there were performed mycological analyses. It is necessary that dentists have certain knowledge of psychology and psychopathology, in order to understand the mechanism of psychopathological reactions and avoid them.
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Sink, Bogdan Adrian, Silviu Brad, Alin Doru Tanase, and Alexandru Bogdan Brad. "OPG Fine Preoperative Evaluation of Maxillary Inflammatory and Atrophic Lesions with Postoperative Successfully Surgical Solutions Appreciation of Dentoalveollary Reconstructions Using Heterolog Membranes and Materials Toghether with Metallic Implants." Revista de Chimie 70, no. 11 (December 15, 2019): 4057–59. http://dx.doi.org/10.37358/rc.19.11.7701.
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The purpose of this paper is to point out the value of OPG exam in pre and postoperative diagnosis assessment of maxillary inflammatory and atrophic lesions with the very full appreciation of surgical solutions and local integration of heterolog membranes and materials together with metallic implants used to repair the osseous defects and rehabilitate the dental status. There were statistically retrospective evaluated the pre and postoperative results of OPG exams of 47 patients with maxillary inflammatory and atrophic lesions clinically and biologically assessed, treated and dental rehabilitated by metallic implants at ESTETIQDENT, a dental medicine practice from Petrosani. In all cases we proceeded to surgical extraction of the non-vital teeth and ultrasonic plaques remove. In the presence of inflammatory radicular cysts, surgical radicular cysts removement and curettage of the periradicular granuloma were the elected choice together with heterolog membranes and materials repair of the osseous defects. When it was necessary, the existent prosthesis works were removed and in order to obtain the bone support, internal or external sinus lift and regional bone addition were performed for dental status rehabilitation through metallic implants. The OPG preoperative exams clearly showed the extent, the morphological characteristics and the topoanatomic reports, in all cases of maxillary inflammatory and atrophic lesions together with regional endodontic status. The postoperative OPG revealed the very local results of surgery procedures and the integration of heterolog membranes and materials used to repair the osseous defects and the dental status rehabilitation by metallic implants. The OPG exam is the imaging method of choice in pre and postoperative diagnosis assessment of maxillary inflammatory and atrophic lesions with the full appreciation of surgical solutions and local integration of heterolog membranes and materials together with metallic implants used to repair the osseous defects and rehabilitate the dental status, due to highly specific abilities in bone tissue evaluation of all maxillary skeletal and dental segments.
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Grecu, Alexandru Gratian, Andra Elena Aungurencei, and Dan Lucian Dumitrascu. "Relation Between Clinical Oral Health Status, Oral Health Related Quality of Life, Denture Material Type and Self-perceived General Health, in a General Population." Revista de Chimie 70, no. 9 (October 15, 2019): 3315–24. http://dx.doi.org/10.37358/rc.19.9.7541.
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The purpose of the current study was to assess the oral health related quality of life (OHRQoL), general health related quality of life (HRQoL), clinical oral and denture status, as well as their interrelation, within a hospitalized general population. The Romanian versions of the Oral Health Impact Profile-49 (OHIP-49Ro), SF-36 questionnaires, together with an additional set of oral health assessment questions, were administered under the interview format to 170 patients, hospitalized in the Second Medical Clinic of Internal Medicine, Cluj-Napoca, Romania. The patients also underwent clinical examination, based on which the DMFT was calculated. Denture status, was as well, registered, together with the denture material. Each patient provided informed consent, prior to any examination. Questionnaire scores were calculated and used for the univariate descriptive statistics, reflecting oral health, OHRQoL and HRQoL sample tendencies. Successively, multiple regression analysis was applied, with the purpose of investigating the relationship between: the clinical oral health status, OHRQoL and HRQoL. In the first model, OHRQoL, while in the second model the dependent variable was represented by the HRQoL, each having a set of established predictors. Additionally, for denture wearing patients, OHRQoL variations in respect to the denture material were assessed, using one-way ANOVA. The mean OHIP-49Ro overall score was 31.90. The mean SF-36 subscales score was 60.66. The mean DMFT score was 18.47. For both regression analyses, all the regression models were significant. For the first model, the predictors accounted for 48.5% of variance in OHRQoL. For the second model, the highest percent of variance, explained by the predictors, was registered for the Mental Health subscale (22.8%). DMFT, as a clinical measure, was a statistically significant predictor rather for the perception in general health. However, OHRQoL was a good predictor for HRQoL, as an integrated part of it. Moreover, the one-way ANOVA indicated statistically significant differences in OHRQoL perception, in respect to the denture material F(2, 82) = 3.253, p = 0.044. The current study indicated complex relations between the patients� clinical status, the OHRQoL and HRQoL. The clinical determinants presented direct impact on both OHRQoL and HRQoL. More balanced HRQoL scores suggested that patients focused more on the perception of general health outcomes.
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Rumini, Rumini, and Norhikmah Norhikmah. "Evaluasi System Usability Scale Pada Sistem Presensi Pengunjung Resource Center." JURIKOM (Jurnal Riset Komputer) 9, no. 4 (August 30, 2022): 1145. http://dx.doi.org/10.30865/jurikom.v9i4.4721.
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Resource center (RC) or can be called also in this case is a library. The library is a place to study or to access information. The RC system of Amikom Yogyakarta University has attendance services for visitors from the user side, namely internal students and external visitors and stores visitor data to find out how many people visit the library, both internal and external visitors. Usability problems that usually appear in system features for users, indicate the need for usability testing. Usability testing uses the SUS (System Usability Scale) method in order to find problems with the visitor attendance system by referring to usability principles, which can involve users. This research was conducted in 3 main stages, namely compiling a questionnaire in accordance with the provisions of the SUS method, processing the results of the respondents' answers from those distributed to visitors by the SUS method rules to obtaining test results in the form of SUS scores. Based on the results of the evaluation carried out, the average SUS score from the study was 55.56, which means it has a D rating (less) which indicates that the presence system visitor feature cannot be accepted by users from the usability aspect, it is still minimal in use, because it only stores visitor data, the recommendations given from the results of this evaluation in order to increase usability for visitor features are such as visitor entry hours, exit hours, input facilities in the form of input related to collections of books, journals, magazines, e-books, facilities inside, room atmosphere, and others, because things like this affect the optimal library services for visitors.
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Andreev, Dmitry E., Michael Niepmann, and Ivan N. Shatsky. "Elusive Trans-Acting Factors Which Operate with Type I (Poliovirus-like) IRES Elements." International Journal of Molecular Sciences 23, no. 24 (December 7, 2022): 15497. http://dx.doi.org/10.3390/ijms232415497.
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The phenomenon of internal initiation of translation was discovered in 1988 on poliovirus mRNA. The prototypic cis-acting element in the 5′ untranslated region (5′UTR) of poliovirus mRNA, which is able to direct initiation at an internal start codon without the involvement of a cap structure, has been called an IRES (Internal Ribosome Entry Site or Segment). Despite its early discovery, poliovirus and other related IRES elements of type I are poorly characterized, and it is not yet clear which host proteins (a.k.a. IRES trans-acting factors, ITAFs) are required for their full activity in vivo. Here we discuss recent and old results devoted to type I IRESes and provide evidence that Poly(rC) binding protein 2 (PCBP2), Glycyl-tRNA synthetase (GARS), and Cold Shock Domain Containing E1 (CSDE1, also known as UNR) are major regulators of type I IRES activity.
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Petrovic, Zarko, Slobodan Rankovic, Marina Mijalkovic, and Bojan Milosevic. "Analytical study of the section of the rc beams strengthened for flexure with FRP materials." Facta universitatis - series: Architecture and Civil Engineering 19, no. 1 (2021): 15–30. http://dx.doi.org/10.2298/fuace210719003p.
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Strengthening of concrete structures is applied as a solution for various deterioration problems in civil engineering practice. This paper presents an analytical study of the behaviour of cross-section of reinforced concrete (RC) beam, strengthened for flexure with fiber reinforced polymer (FRP) materials. Using the balance of internal forces in the cross section through all phases of stress through which the section passes, a program was written in the MATLsoftware, the execution of which produced a curve of dependence between bending moment and curvature, which is one of the most important indicators of cross section behaviour. The parameters varied in this study are the amount and type of FRP reinforcement and the obtained results indicate a significant influence of additional FRP reinforcement both on the yielding and ultimate bending moment, and on the bending stiffness of the strengthened cross section.
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Mammadova, Leyla. "COMPARATIVE ANALYSIS OF CLUSTER VALIDITY INDICES IN TERMS OF CONSISTENCY." Problems of Information Technology 13, no. 2 (July 6, 2022): 24–39. http://dx.doi.org/10.25045/jpit.v13.i2.03.
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Cluster analysis is one of the key issues in Data Mining, the most important stage of the Knowledge Discovery from Data (KDD) process, and is widely used. There are 3 main tasks of cluster analysis: determining the optimal number of clusters, clustering algorithms and evaluating the quality of clustering. One of the most important steps in cluster analysis is to evaluate the quality of clustering. A number of indices have been proposed to assess the outcome of clustering. The analysis shows that these indices, which are used to assess the quality of clustering, often show inconsistent results. Therefore, extensive research has recently been conducted on the study of indices and new indices are proposed. The article examines a number of internal and external evaluation indices. Different size data sets are taken and k-means, k-medoids, agglomerative hierarchical, BIRCH and OPTICS algorithms are applied to them. A number of internal and external evaluation indices are used to assess the results of the experiment, and the results are analyzed comparatively. Experiments show that Ac, Pr, Rc and F-m indices show similar results in in group determining in a given clustering structure.
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González, Jinela, Dafni Mora, and Miguel Chen Austin. "The Thermal Network Approach to Model Occupants’ Heat and CO2 Generation Interactions: A Case Study in an Office Building in Panama." Journal of Physics: Conference Series 2385, no. 1 (December 1, 2022): 012015. http://dx.doi.org/10.1088/1742-6596/2385/1/012015.
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Abstract This investigation proposes a methodology to predict indoor air temperature and CO2 levels. For this, a two-occupant office inside a building in the Technological University of Panama is taken as a case study and modeled in Designbuilder simulation software validated via experimental data. Here, a mathematical model that considers internal heat gains by the occupants and CO2 emissions, including physical characteristics and activities developed, is constructed via the thermal network (RC) and system identification approaches. Three linear grey-box models are identified: a 4R2C for cooling system mode, a 3R2C for natural ventilation conditions, and a 1R1C for CO2 model. The results showed that the identified model is useful for estimating the indoor air temperature under both modes: “natural ventilation on” and “cooling system on,” in separated situations. Thus, it is determined that by incorporating the internal heat gain generated by the occupant in the model identification process, the data set is closer to real values than implementing a standard value as suggested by the literature. On the contrary, the CO2 model allowed an approximation between estimated and real data, but this prediction must be developed in a non-linear model for better results.
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Hui, Liu. "Two Time Point Analysis of the Change in Risk and Aging Factors for Major Cancers: A 10-Year Longitudinal Study in China." BioMed Research International 2020 (May 7, 2020): 1–7. http://dx.doi.org/10.1155/2020/9043012.
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Objective. To quantify the change in risk and aging factors with a two time point analysis for major cancers to assess supportive strategies. Methods. The 2004 and 2015 mortality statistics in China were accessed. The standardized mortality rates of the two periods were used to calculate the ratio of change (RC) value to assess the risk of death associated with time (social development with time) for cancers. The role of age in mortality with time was evaluated by the interaction between time and age using a Poisson regression. Results. In ascending order of RC, the factors were uterus; other malignant neoplasms; esophagus; stomach; skin; liver; leukemia; “lip, oral cavity, and pharynx”; bladder; “colon and rectum”; breast; prostate; lung; ovary; pancreas; “lymphoid, hematopoietic, and related tissue”; and cervix cancers. According to their location on the scatter diagram, the 17 neoplasms could be divided into three groups, comprising undeveloped cancers (including four cancers), developed cancers (including three cancers), and cancers insensitive to social development. Unexpectedly, about 60% (as assessed by type of cancer) and two-thirds (as assessed by constituent ratio of death from all cancers) of cancers did not change with time. Conclusions. Most cancers may be insensitive to social development. Internal factors, including aging, may be a key factor for the occurrence of cancer.
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Leschinger, Tim, Christopher Wallraff, Dirk Müller, Matthias Hackenbroch, Henning Bovenschulte, and Jan Siewe. "Internal Impingement of the Shoulder: A Risk of False Positive Test Outcomes in External Impingement Tests?" BioMed Research International 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/2941238.
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Background. External impingement tests are considered as being particularly reliable for identifying subacromial and coracoid shoulder impingement mechanisms. The purpose of the present study was to evaluate if these tests are likely to provoke an internal shoulder impingement mechanism which, in cases of a pathologic condition, can lead to a positive test result.Method. In 37 subjects, the mechanical contact between the glenoid rim and the rotator cuff (RC) was measured quantitatively and qualitatively in external impingement test positions using an open MRI system.Results. Mechanical contact of the supraspinatus with the posterosuperior glenoid was present in 30 subjects in the Neer test. In the Hawkins test, the subscapularis was in contact with the anterosuperior glenoid in 33 subjects and the supraspinatus in 18. In the horizontal impingement test, anterosuperior contact of the supraspinatus with the glenoid was identified in 35 subjects.Conclusion. The Neer, Hawkins, and horizontal impingement tests are likely to provoke the mechanism of an internal shoulder impingement. A posterosuperior internal impingement mechanism is being provoked predominately in the Neer test. The Hawkins test narrows the distance between the insertions of the subscapularis and supraspinatus and the anterosuperior labrum, which leads to an anterosuperior impingement mechanism.
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Zolnikov, V., F. Makarenko, I. Zhuravleva, Elena Popova, Yu Gridnev, and Yuliya Litvinova. "Circuit engineering methods for ensuring ECB resistance to the effects of heavy charged particles." Modeling of systems and processes 14, no. 4 (January 8, 2022): 35–42. http://dx.doi.org/10.12737/2219-0767-2021-14-4-35-42.
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The paper considers circuit engineering methods for protecting the electronic component base from the effects of heavy charged particles. One of the main methods is to increase the capacity of the device, which leads to an increase in the capacity of diffusion regions and a decrease in the frequency of single events. The structure of a capacitor is shown, which is connected to various nodes of the circuit to increase the sensitivity of the capacitance of the node. The article focuses on the method of using active RC circuits in the feedback circuit of a storage device cell. The advantages and disadvantages of the methods of using a storage device cell with internal redundancy are noted. The paper shows that the use of circuit engineering methods will provide the required level of fault and fault tolerance to the effects of heavy charged particles.
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Duru, Kamala, Praneash Venkatachalam, Chanakya Karra, Asha Anish Madhavan, Karthikeyan Elumalai, and Sujith Kalluri. "Lithium-Ion Battery Model Parameters Estimation Using Equivalent Circuit Model for E-mobility Applications." ECS Transactions 107, no. 1 (April 24, 2022): 7485–500. http://dx.doi.org/10.1149/10701.7485ecst.
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Accurate estimation of battery internal model parameters and consequently SOC prediction is crucial in any battery power system. Hence, it is a fundamental need in electric vehicles, smart grids, and energy storage systems. The accuracy of parameters identification will affect the battery management system, battery safety, characteristics, and performance, which mainly depends on battery model parameters. So, to estimate the parameters accurately and easily, we require effective, simple, and robust parameters estimation algorithms. In this article, we propose a new method for estimation of parameters using least square method algorithm for Lithium-Ion Batteries (LIBs) for Electric Vehicle (EV) applications. In this, a second-order RC equivalent circuit model is considered for estimation of parameters of NMC battery. The estimation of parameters and relation between OCV-SOC nonlinear is obtained from the experimental data. This proposed method shows that the calculation of parameters is fast and efficient.
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Vinichenko, I., and A. Lishinska. "FORENSIC MEDICAL EVALUATION OF DETECTION CELLS OF HEINZEEHRLICH SMEARS OF CADAVERIC BLOOD IN CASES OF SUDDEN DEATH OF NEWBORNS AND CHILDREN UNDER ONE YEAR OF LIFE." Forensic-medical examination, no. 2 (November 20, 2015): 118–23. http://dx.doi.org/10.24061/2707-8728.2.2015.18.
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The aim of the study was to conduct a forensic evaluation of the detection cells of Heinze-Ehrlich smears of cadaveric blood in cases of sudden death ofnewborns and children under one year of life for an unknown tanatogenesis. Materia and research methods. Treated 15 cases of death of children, ranging in age from 22 days to 11 years for the period from 2013 to RC, which had the effect titovsky connections. Given external and internal changes, histological picture and the detection in blood smears of different number of cells Heinze-Ehrlich erythrocytes, a study of well water, these cases are divided into IU-ri group. In cases of sudden death of infants, children up to 1 year when tanatogenez difficult to trace, and also in cases where the in vivo studyof blood content of methemoglobin was carried out determination of the presence of Taurus Heinze-Ehrlich smears of cadaveric blood is an important diagnostic signs.
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Longo, Umile Giuseppe, Giacomo Rizzello, Stefano Petrillo, Mattia Loppini, Nicola Maffulli, and Vincenzo Denaro. "Conservative Rehabilitation Provides Superior Clinical Results Compared to Early Aggressive Rehabilitation for Rotator Cuff Repair: A Retrospective Comparative Study." Medicina 55, no. 8 (July 24, 2019): 402. http://dx.doi.org/10.3390/medicina55080402.
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Background and objectives: To compare the long term clinical outcomes, range of motion (ROM) and strength of two different postoperative rehabilitation protocols after arthroscopic rotator cuff repair (RCR) for full-thickness rotator cuff (RC) tears. Materials and Methods: Patients undergoing RCR were divided into two groups. In 51 patients (56 shoulders), rehabilitation was performed without passive external rotation, anterior elevation ROM, and active pendulum exercises in the first 2 weeks after surgery (Group A). In 49 patients (50 shoulders) aggressive rehabilitation was implemented, with early free passive external rotation, anterior elevation ROM, and active pendulum exercises were allowed from the day after surgery (Group A). Results: No statistically significant differences were found in clinical scores, muscle strength, passive forward flexion, passive and active internal/external rotation between the two groups. However, the mean active forward flexion was 167.3° ± 26° (range 90–180°) in group A and 156.5° ± 30.5° (range 90–180°) in group B (p = 0.04). Conclusions: A statistically significant difference between the 2 groups was found in active forward flexion ROM, which was better in patients of group A.
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Hammou, Abdelilah, Hicham Chaoui, and Hamid Gualous. "Supercapacitor State of Health Estimation for Vehicular Applications." ECS Meeting Abstracts MA2022-01, no. 6 (July 7, 2022): 2413. http://dx.doi.org/10.1149/ma2022-0162413mtgabs.
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The transportation electrification requires an energy storage system that can absorb and deliver high amounts of energy during short periods of time, such us acceleration and breaking phases. One of the solutions applied is the using of electrical double layer capacitors (ELDC) or supercapacitors, due to their higher power density. However, the performance and the safety of these components depend on their state of health (SoH). Therefore, the health monitoring of supercpacitor cells is necessary to assure their integration and their safety in vehicular application. The aging of supercapacitors is usually correlated with the decreasing of their capacitance end the increasing of their internal resistance. Thus, the monitoring of these two parameters is necessary for the diagnosis of the state of heath. The measuring of these two parameters cannot be performed directly during the working conditions of supercapacitors in electrical vehicles. Therefore, an online estimation approach of these parameters is needed to enable the diagnosis of supercapacitors. This paper proposes a model-based method for supercapacitors state of health estimation. The approach uses the high gain observer to estimate the parameters of the equivalent RC network. The high gain observer, is one of the observers used for the system identification, it has shown its accuracy and robustness for dealing with nonlinear systems. The equivalent RC network used for modeling the system, simulates the energy and the electrical behavior of supercapacitors, it also presents a best tradeoff between accuracy and complexity. This approach enables the estimation of supercapacitors capacitance and internal resistance from current and voltage measurements. In order to test the proposed method, an experimental test was realized to validate this method. During this test two supercapacitors cells were cycled, in a climate chamber at high temperature T=45°C, in order to accelerate their aging. After each number of cycles, the supercapacitors cells are discharged using WLTC current profile (World harmonized Light-duty vehicles Test Cycle) presented in figure 1. Then, the capacitance and the internal resistance were measured to calculate their state of health. The WLTC current profiles is a dynamic current profile composed of charge and discharge current which allow to test the performance and the diagnosis method in conditions close to real electrical vehicles conditions. Since the aging of supercpacitor is correlated with the evolution of their capacitance and their internal resistance, then the state of health of these components is defined based on these two parameters using these two equations: and are the resistance and the capacitance measured at the beginning of life, and and and are and the resistance the capacitance measured at the end of each state of health k. After each number of cycles, the parameters of the RC equivalent circuit model were estimated, using the high gain observer, from the voltage and current measured during WLTC current profile. In order to compare results, the Root mean square error (RMSE) is calculated between the measured and the estimated SoHr and SoHc. The results presented in figure 2 and figure 3 and table I, show that the high gain observer presents a good accuracy for the state of health estimation, with an RMSE less than 0.77% for the SoHc and less than 1.58% for SoHr estimation. These results, indicate to robustness and the accuracy of this approach to estimate the supercpacitor parameters from a dynamic current profile such as WLTC, which make the used approach a good candidate for on board diagnosis in vehicular applications. The future work of this study is to implement this algorithm in microprocessor in order to test its performance in a real time. References Chaoui, A. El Mejdoubi, A. Oukaour, and H. Gualous: "Online System Identification for Lifetime Diagnostic of Supercapacitors with Guaranteed Stability", IEEE Transactions on Control Systems Technology, Volume: 24, Issue: 6, pages 2094-2102, November 2016. Li and K. Wang, "The Literature Review on Control Methods of SOH and SOC for Supercapacitors," 2019 4th International Conference on Control, Robotics and Cybernetics (CRC), 2019, pp. 17-21, doi: 10.1109/CRC.2019.00013. Saha, P. Saha and M. Khanra, "Performance Comparison of Nonlinear State Estimators for State-of-Charge Estimation of Supercapacitor," 2021 IEEE Second International Conference on Control, Measurement and Instrumentation (CMI), 2021, pp. 105-109, doi: 10.1109/CMI50323.2021.9362850. El Mejdoubi, H. Chaoui, H. Gualous and J. Sabor, "Online Parameter Identification for Supercapacitor State-of-Health Diagnosis for Vehicular Applications," in IEEE Transactions on Power Electronics, vol. 32, no. 12, pp. 9355-9363, Dec. 2017, doi: 10.1109/TPEL.2017.2655578. Figure 1
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Zhao, Moxuan. "An Improved EKF Algorithm for SOC Estimation of Lithium Battery Considering Temperature Effects." Journal of Physics: Conference Series 2395, no. 1 (December 1, 2022): 012070. http://dx.doi.org/10.1088/1742-6596/2395/1/012070.
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Abstract In order to improve the estimation accuracy of the state of charge (SOC) of lithium-ion power batteries during use, an estimation method that considers different temperature effects is proposed in this paper. First, the second-order resistor-capacitor (RC) circuit model is selected as the research model based on a comparative analysis of different models. Then, the parameters in the circuit model are identified online in real time under different temperatures to analyze the temperature effects on internal parameters. Lastly, the noise variance can be automatically adjusted according to the environment by using the improved extended Kalman filter (EKF) algorithm with the differential evolution algorithm, which optimizes the fixed process noise variance in the original EKF algorithm. The changing noise variance is substituted in the original EKF algorithm to estimate SOC under cycle working conditions online. The results show that the improved EKF algorithm increases the estimation accuracy of the SOC of lithium batteries. Using the improved EKF algorithm, the estimated value can quickly converge to the actual value at different temperatures, and the SOC error remains within 2% in the whole estimation process.
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Agustina, Sri, Ramayanty Bulan, and Agustami Sitorus. "Prediction of mango firmness by near infrared spectroscopy tandem with machine learning." Computer Science and Information Technologies 3, no. 3 (November 1, 2022): 148–56. http://dx.doi.org/10.11591/csit.v3i3.p148-156.
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The firmness of the mango fruit is one of the internal physical properties that can show its quality. Unfortunately, non-destructive methods to measure this are not yet available. In the current study, we develop a calibration model using near infrared spectroscopy to predict the physical properties (firmness) of the mango cultivar Arumanis (Mangifera indica cv. Arumanis) via machine learning. Spectral data were acquired using the fourier transform near-infrared (FTNIR) benchtop with a wavelength range of 1000 to 2500 nm. Multivariate spectra analysis based on machine learning, including principal component regression (PCR), partial least squares regression (PLSR), and support vector machine regression (SVMR), was utilized and compared to estimate the firmness of fresh mangos. The results obtained show that the prediction of machine learning by PLSR is better than that of SVMR and PCR for the prediction of mango firmness. The coefficient correlation of calibration (rc) and validation (rcv), the root means square error of calibration (RMSE-C) and validation (RMSE-CV), and the ratio of prediction to deviation (RPD) were 0.941, 0.382 kgf, 0.920, 0.472 kgf, and 2.556, respectively. The general results satisfactorily indicate that near infrared spectroscopy technology integrated with an appropriate machine learning algorithm has optimistic results in determining the firmness of mango non-destructively.
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Silva, Fabiano Müller, Vinicius Ronzani Cerqueira, and Giovanni Lemos de Mello. "Economic analysis of common snook, Centropomus undecimalis, cultured in floating cages in southern Brazil." Agropecuária Catarinense 35, no. 3 (December 26, 2022): 62–69. http://dx.doi.org/10.52945/rac.v35i3.1472.
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The economic viability of common snook culture was evaluated from a simulated marine farm with 20 cages of 225m³, with a production cycle of two years, fish with a final weight of 500g and annual production of 45 tons. To scale the production costs, the effectve operating cost (EOC), total operating cost (TOC), total production cost (TPC) were considered.The indices for evaluating profitability were the Internal Rate of Return (IRR), the Return on Capital (RC) and the Net Present Value (NPV). The TPC was USD $305,820 year-1, with USD $6.79 kg-1. Sensitivity analysis by the variation of the feed conversionrate (FCR) reinforces the importance of good production practices, such as adequate food management, use of balanced diets. The factors: juvenile price, feed cost and sales price, more dependent on the market, require a greater ability of the producer to apply commercial and marketing strategies to contain the production cost and avoid the reduction of the sales price. The high cost of installing culture structures and management equipment suggests projects with a minimum rate of attractiveness of 23%, minimum volume of 6,500m³, productivity of 20kg m-³, annual production of 65 tons, FCR below 1.6 and marketing price above USD$8.39 kg-1.
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Radulovic, Sinisa, Ana Maria Comaru-Schally, Slobodan Milovanovic, and Andrew V. Schally. "Somatostatin Analogue RC-160 and LH-RH Antagonist SB-75 Inhibit Growth of MIA PaCa-2 Human Pancreatic Cancer Xenografts in Nude Mice." Pancreas 8, no. 1 (January 1993): 88–97. http://dx.doi.org/10.1097/00006676-199301000-00016.
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Ouyang, Huizi, Fang Liu, Zhidan Tang, Xiaopeng Chen, Fang Bo, Huaming Liu, Yanxu Chang, and Jun He. "A Validated LC-MS/MS Method for Simultaneous Determination of Six Aconitum Alkaloids and Seven Ginsenosides in Rat Plasma and Application to Pharmacokinetics of Shen-Fu Prescription." Evidence-Based Complementary and Alternative Medicine 2018 (June 28, 2018): 1–12. http://dx.doi.org/10.1155/2018/5107083.
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A sensitive and reliable LC-MS/MS method has been developed and validated for simultaneous determination of six Aconitum alkaloids (aconitine, hypaconitine, mesaconitine, benzoylaconitine, benzoylhypacoitine, and benzoylmesaconine) and seven ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, and Rg1) in rat plasma after oral administration of Shen-Fu prescription. Psoralen was selected as internal standard (IS). Protein precipitation with methanol was used in sample preparation. The chromatographic separation was achieved on a CORTECS™ C18 column with 0.1% formic acid aqueous solution and acetonitrile as mobile phase. The flow rate was 0.3 mL/min. The detection was performed on a tandem mass system with an electrospray ionization (ESI) source in the positive ionization and multiple-reaction monitoring (MRM) mode. The calibration curves of six Aconitum alkaloids and seven ginsenosides were linear over the range of 0.1-50 and 1-500 ng/mL, respectively. The extraction recoveries of the analytes in plasma samples ranged from 64.2 to 94.1%. Meanwhile, the intra- and interday precision of the analytes were less than 14.3%, and the accuracy was in the range of −14.2% to 9.8%. The developed method was successfully applied to the pharmacokinetics of six Aconitum alkaloids and seven ginsenosides in rat plasma after oral administration of Shen-Fu prescription.
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Hong, Shu-Kun, Shi-Yong Yang, Shao-Hua Yin, and Kun-Xing Yang. "RC-3095, a Gastrin-Releasing Peptide Receptor Antagonist, Synergizes With Gemcitabine to Inhibit the Growth of Human Pancreatic Cancer CFPAC-1 In Vitro and In Vivo." Pancreas 43, no. 1 (January 2014): 15–21. http://dx.doi.org/10.1097/mpa.0b013e3182a714cf.
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Buddhi Satyarini, Triwara. "Economic performance of the “Emping Melinjo” household industry and the entrepreneurial character of the business owner." E3S Web of Conferences 316 (2021): 02009. http://dx.doi.org/10.1051/e3sconf/202131602009.
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Many of the melinjo chips household industries in Bantul have been operating for a very long time, are still included in the household industry scale, proving that the industry is not developing. This study aims to determine: 1) the entrepreneurial character of the melinjo chips household industry; 2) factors that correlate with entrepreneurial character 3) business feasibility of melinjo chips; 4) the relationship between entrepreneurial character and economic performance of the business. This research is a descriptive study conducted with a survey method of 60 respondents in Bantul Regency. The method analysis are using table analysis and regretion analysis The results showed that the entrepreneurial character of the emping melinjo business owner in Bantul being studied were achievement motivation and leadership (quite low), responsive and creative in facing the future (low) and business networks (very low). The character of achievement motivation influences other entrepreneurial characters. The external factor that affects the character of entrepreneurship is government support. The feasibility level of the melinjo chips business is measured by an RC ratio of 1, a capital productivity level of 3% and a labor productivity level of 206,800 / HOK. The entrepreneurial character of a broad business network and availability of labor have an effect on the feasibility of an R/C business and capital productivity. Internal factors of family support have a negative effect on company performance in labor productivity.
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Vandevoort, Brecht, Bas Ketsman, Christoph Koch, and Frank Neven. "Robustness against read committed for transaction templates." Proceedings of the VLDB Endowment 14, no. 11 (July 2021): 2141–53. http://dx.doi.org/10.14778/3476249.3476268.
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The isolation level Multiversion Read Committed (RC), offered by many database systems, is known to trade consistency for increased transaction throughput. Sometimes, transaction workloads can be safely executed under RC obtaining the perfect isolation of serializability at the lower cost of RC. To identify such cases, we introduce an expressive model of transaction programs to better reason about the serializability of transactional workloads. We develop tractable algorithms to decide whether any possible schedule of a workload executed under RC is serializable (referred to as the robustness problem). Our approach yields robust subsets that are larger than those identified by previous methods. We provide experimental evidence that workloads that are robust against RC can be evaluated faster under RC compared to stronger isolation levels. We discuss techniques for making workloads robust against RC by promoting selective read operations to updates. Depending on the scenario, the performance improvements can be considerable. Robustness testing and safely executing transactions under the lower isolation level RC can therefore provide a direct way to increase transaction throughput without changing DBMS internals.
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Gadau, Carmen, Elena Ardeleanu, Roxana Folescu, Ioan Tilea, Andreea Varga, Alexandra Simona Zamfir, Mihaela Boanca, et al. "Prevalence, Characteristics and Predictive Factors of Microalbuminuria in Resistant Systemic Arterial Hypertension." Revista de Chimie 69, no. 9 (October 15, 2018): 2425–29. http://dx.doi.org/10.37358/rc.18.9.6546.
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The present cross-sectional observational study was made in family medicine offices of Timi� County, Romania. The aim of the study was to investigate the prevalence of urinary microalbumin excretion (MAU) in resistant systemic arterial hypertension (RH), to analyze patients� biochemical and clinical characteristics, and the predictive factors for MAU. From a total number of 347 patients, MAU was detected in 76 cases (21.9%). The microalbuminuria positive patients were older, with significant higher office systolic blood pressure (BP) (155 � 13.50 vs 148 � 12.40 mmHg, p [ 0.0001) and diastolic blood pressure (94 � 12.20 vs 88 � 14.6 mmHg, p = 0.0013), higher prevalence of left ventricular hypertrophy, diabetes mellitus, obesity, ischemic and peripheral arterial disease. MAU positive patients presented statistical significant differences in biochemical data concerning: fasting plasma glucose (FPG) (118.80 � 32.02 vs 108.01 � 26.01 mg/dL, p = 0.003), impaired glucose tolerance (IGT) (10.52 % vs 4.94 %), glycated hemoglobin (HbA1c) (6.56 � 0.98% vs 5.96 � 0.91%, p [ 0.001), reduced estimated glomerular filtration rate (eGFR) (56.10 � 15.4 vs 69.30 � 17.5 ml/min/1.73m2, p [ 0.001) and higher potassium levels (4.71 � 0.43 vs 4.59 � 0.44 mg/dL, p = 0.0378). No significant differences were noticed regarding LDL- and HDL-cholesterol, triglycerides, uric acid and serum creatinine. In a logistic multivariate analysis independent predictors for MAU were: systolic BP (odds ratio, OR = 1.024, 95% confidence interval, CI:1.011-1.039, p [ 0.001), HbA1c (OR = 1.324, 95% CI: 1.078-1.724, p = 0.008) and eGFR (OR = 0.989, 95% CI: 0.977-0.999, p = 0.01). Our findings suggest that an important part of RH patients have microalbuminuria and highlight the importance of controlling its predictors, in order to improve patients� outcome.
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AlAnazi, Amal, Ahmad H. Alghadir, and Sami A. Gabr. "Handgrip Strength Exercises Modulate Shoulder Pain, Function, and Strength of Rotator Cuff Muscles of Patients with Primary Subacromial Impingement Syndrome." BioMed Research International 2022 (August 30, 2022): 1–17. http://dx.doi.org/10.1155/2022/9151831.
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Background. Impingement syndrome was shown to be associated with shoulder pain in 44–70% of patients worldwide. It usually occurs due to imbalance and insufficient activation of the rotator cuff (RC) muscles. Aim. This study explores the relative effects of handgrip-strengthening exercises on shoulder function, pain, strength, and active range of motion as part of the treatment program for the patients with primary subacromial impingement syndrome. Materials and Methods. A total of 58 patients aged 18-50 years with primary subacromial impingement syndrome were randomly enrolled to participate in this single-blind randomized clinical trial. Out of them, only forty patients have eligibly matched the inclusion criteria and randomly assigned to one of two groups to undergo a standardized therapeutic program consisting of two sessions a week for 8 weeks. The control group prescribed ultrasound therapy, ice, and stretching exercises, while the experimental group followed the same program with the addition of handgrip-strengthening exercises (HGSE). Both patients of conventional therapy (control) and handgrip-strengthening exercises (experimental group) were advised to adhere also to stretching and HGSE exercises once a day at home for eight weeks. The outcomes were the shoulder function, pain intensity, muscle strength, and active range of motion of the shoulder joint. Results. Patients treated with conventional interventions plus handgrip-strengthening exercises showed the significant improvement over time in shoulder pain and function, strength of rotator cuff muscles, and pain-free range of motion forward flexion, abduction, and external and internal rotation through eight weeks in the experimental group compared to control patient group treated with conventional interventions. In addition, patients of both control and experimental groups showed no significant difference in the adherence to respective home-based stretching and HGSE exercises once a day at home for eight weeks. Conclusions. Adding handgrip-strengthening exercises to conventional intervention increases the efficacy of treatment for patients with primary subacromial impingement syndrome in terms of shoulder function, pain, muscle strength, and active range of motion.
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Motta, Camilla Caetano Alves da, Bruna Marques Lopes, Ana Flavia Calvo, Katharina Leal Goto, Pedro Henrique Simm Pires de Aguiar, Nilton Alves Lara Junior, and Paulo Henrique Pires de Aguiar. "DBS treatment in an 18-year-old with refractory dystonia due to DYT1 mutation: a case report." Revista de Medicina 100, esp (November 8, 2021): 19. http://dx.doi.org/10.11606/issn.1679-9836.v100iespp19-19.
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Introduction: The term dystonia may be defined by abnormal involuntary movements or postures due to sustained or intermittent muscle contractions. One of the most common aetiologies of isolated dystonia is due to the mutation in DYT1 gene, resulting in a disorder of abnormal regulation of gene transcription and neuronal circuit development. Of all the patients with this mutation, about 30-40% will develop symptoms of the disease. Typically, the clinical manifestation of this type of dystonia will begin from the first to third decade of life, with generalized distribution, and involving more likely the lower limbs or, less frequently, the upper limbs and trunk. Objective: To present a case of an infrequent refractory dystonia due to DYT1 gene mutation in an 18-year-old male patient that was later treated with Deep Brain Stimulation (DBS). Case report: Here we report about the case of a 18-year-old male patient affected by torsion dystonia of the neck and a segment of the upper limbs. He first exhibited symptoms when he was 15 years old and, since then, has had a series of complications, such as severe pain and recurrent pneumonia. Genetic analysis identified a DYT1 gene superexpression mutation. Previous therapies had included physiotherapy, botulinum toxin injections, drugs such as primidone and clonazepam, but all with little improvement. Due to the patient's severe torsion dystonia on his right side, it was decided to implant a DBS only in the left internal globus pallidus (GPi) posteromedial area, in a brain surgery with general anesthesia that took place in March 2018. After 10 months, the same procedure was made in the right GPi, at the subthalamic nucleus, aiming to treat his dystonic tremors located in the left part of the body. The electrodes inserted were Medtronic® 3389 and the generator was Activa RC rechargeable, with 0.5 mm spacing. The following programming was set: current of 3 mA, frequency of 130 Hz and pulse width of 90 μs. The battery of the electrode was inserted in the right side of the chest due to the patient's more severe torsion. The post-operative (PO) was successful, without any deficit, being discharged from the hospital at the PO day 4 in the first surgery and day 2 and in the second. After a 2-year follow-up period, the patient presents a normal life compared to the average of his age, without any of the symptoms or complications he had before. He regularly attends physiotherapy and fitness centres to maintain muscle training.
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Leong, Hio Teng, and Siu Ngor Fu. "The Effects of Rigid Scapular Taping on the Subacromial Space in Athletes With and Without Rotator Cuff Tendinopathy: A Randomized Controlled Study." Journal of Sport Rehabilitation 28, no. 3 (March 1, 2019): 250–55. http://dx.doi.org/10.1123/jsr.2017-0287.
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Context:Reduction of the subacromial space (SAS) during arm elevation may contribute to rotator cuff (RC) tendinopathy. The effects of scapular taping on the SAS in athletes with and without RC tendinopathy are unknown.Objective:To investigate the immediate effects of scapular taping on the SAS in athletes with and without RC tendinopathy.Design:Randomized controlled study with repeated measures.Setting:University laboratory.Participants:A total of 43 male volleyball players (17 asymptomatic and 26 with RC tendinopathy, mean age = 22.9 [3.5] y) participated in the study.Intervention:Three scapular taping protocols—no taping (control), taping with tension (therapeutic taping), and taping without tension (sham taping).Main Outcome Measures:Ultrasound measurements of the SAS with the arm at 0° and 60° of shoulder abduction, and the change in the SAS between 0° and 60° of shoulder abduction (SAS0°–60°) were calculated.Results:Athletes with RC tendinopathy demonstrated larger SAS with therapeutic taping at 60° of shoulder abduction (6.9 [1.9] mm vs 5.8 [1.7] mm, mean difference = 1.1 mm, 95% confidence interval, −1.80 to −0.39,P = .002) when compared with the no taping condition. The tendinopathy group also showed less reduction in the SAS with therapeutic taping during SAS0°–60°(2.0 [1.4] mm vs 2.8 [1.4] mm,P = .02) when compared with the no taping condition. When tape was applied to the scapula in asymptomatic athletes, our results showed a relatively small increase in the SAS with therapeutic taping during arm resting at 0° of abduction when compared with the no taping condition (8.7 [0.9] mm vs 8.3 [0.8] mm, mean difference = 0.4 mm, 95% confidence interval, −0.71 to −0.11,P = .01).Conclusions:Athletes with RC tendinopathy demonstrated less reduction of the SAS with rigid scapular taping during early arm abduction. Such observation was not evidenced in asymptomatic athletes.
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Kotov, S. V., A. О. Prostomolotov, A. A. Nemenov, A. A. Klimenko, and I. S. Pavlov. "Comparison of clips and electrosurgical instruments in sealing of lymphatic vessels during pelvic lymph node dissection at the time of radical cystectomy." Cancer Urology 17, no. 2 (July 25, 2021): 93–102. http://dx.doi.org/10.17650/1726-9776-2021-17-2-93-102.
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Background. Bladder cancer is very common and real problem in oncourology. The main treatment for muscle invasive bladder cancer is radical cystectomy (RC). RC with pelvic lymph node dissection (PLND) may be associated with an increased risk of developing lymphatic complications such as lymphedema, prolonged lymphorrhea, and the formation of lymphocele.Objective: to compare the efficiency of clips and surgical instruments for preventing the development of lymphatic complications during PLND at the time of RC.Materials and methods. From January 2016 to October 2020 at the N.I. Pirogov Russian National Research Medical University on the basis of N.I. Pirogov City Clinical Hospital No. 1 were performed 60 RC with PLND. All patients were divided into two groups. The 1st group included patients who underwent the sealing of lymphatic vessels using titanium/polymer clips (n = 30). In the 2nd group the sealing was performed using ultrasonic/bipolar instruments (n = 30). All operations were performed by one surgeon. The study used univariate and multivariate logistic regression analysis.Results. The overall percentage of lymphatic complications was 29 (48.3 %) out of 60 patients. Out of them 7 (11.7 %) patients developed symptomatic lymphocele, and 3 (5.0 %) developed asymptomatic lymphocele, prolonged lymphorrhea was observed in 17 (28.3 %) patients, lymphedema of the lower extremities or genitals in 2 (3.3 %). The percentage of lymphatic complications in the 1st group was 66.7 % (n = 20), and in the 2nd group - 30.0 % (n = 9) (p = 0.004). In multivariate analysis the statistical significance was (p = 0.014), a high odds ratio (6.83; 95 % confidence interval 1.48-31.49) was observed with sealing of lymphatic vessels with clips, while a low odds ratio (0.14; 95 % confidence interval 0.03-0.67) was found with electrosurgical instruments.Conclusion. The use of ultrasonic or bipolar electrosurgical instruments can be an effective method for preventing the development of lymphatic complications during PLND at the time of RC.
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Nam, Ki Yup, Bum Jun Kim, Woo Hyuk Lee, and Yong Seop Han. "Repeatability of Spectral Domain Optical Coherence Tomography Measurements of Bruch’s Membrane Opening-Minimum Rim Width in Epiretinal Membrane Patients with Peripapillary Involvement." Journal of Clinical Medicine 10, no. 11 (May 21, 2021): 2240. http://dx.doi.org/10.3390/jcm10112240.
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The Bruch’s membrane opening-minimum rim width (BMO-MRW) is a recently introduced parameter of the neuroretinal rim. We analyzed the repeatability of spectral-domain optical coherence tomography (SD-OCT) measurements of BMO-MRW in epiretinal membrane (ERM) patients with peripapillary involvement, since the surface around the optic disc is distorted in such patients. BMO-MRW and retinal nerve fiber layer (RNFL) thickness measurements were performed using SD-OCT in prospectively enrolled ERM patients and age-matched healthy control individuals. After two consecutive measurements with a 5 min interval, repeatability was analyzed using the intraclass correlation coefficient (ICC), repeatability coefficient (RC), and coefficient of variation (CV). Fifty-two eyes of 52 ERM patients and 62 eyes of 62 healthy controls were included in the study. The ICCs of the mean BMO-MRW/RNFL thickness measurements were 0.999/0.985 in ERM eyes and 0.999/0.999 in normal eyes, respectively. The RC values of mean BMO-MRW/RNFL thickness measurements were 9.0/6.25 μm in ERM eyes and 4.61/0.92 μm in normal eyes, respectively. The CV values were 0.91% and 1.45% for BMO-MRW and RNFL thickness in ERM eyes, and 0.63% and 0.33% in normal eyes, respectively. In ERM eyes, the RC, CV of average BMO-MRW were 1.9 and 1.4 times greater than those of normal eyes, but 6.8 and 4.4 times greater for average RNFL thickness. BMO-MRW and RNFL thickness showed good repeatability in the diseased eyes with peripapillary involvement and healthy control eyes. Based on the ICC, RC, and CV values, the repeatability of BMO-MRW measurements in peripapillary membrane patients was better than that of RNFL thickness.
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Nyamuryekung'e, Shelemia, Glenn C. Duff, Richard Estell, Santiago Utsumi, Micah Funk, Andres Cibils, Andrew Cox, et al. "PSXIII-7 Field Testing of Lora-wan Sensors for Real-Time Tracking and Biosensing of Brangus and Raramuri Criollo Cattle Grazing a Small Pasture." Journal of Animal Science 100, Supplement_3 (September 21, 2022): 203. http://dx.doi.org/10.1093/jas/skac247.369.
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Abstract The study’s objective was to investigate the use of Internet of Things (IoT) biosensors using Long Range Wide Area Network (LoRa-WAN) communication to compare the foraging behavior of two desert adapted cattle breeds. Two groups of mature Brangus (BA) and Raramuri Criollo (RC) cows were introduced into a small irrigated pasture (38ha) at the New Mexico State University’s Clayton Livestock Research Center during Dec-Jan, 2021 (41-days). The real-time position and activity count data (15- and 1-minute interval, respectively) were retrieved continuously from 4 BA and 5 RC cows collared with commercially available trackers (Abeeway Industrial-trackers). Response variables derived from GPS records included daily distance traveled (Dist) and daily area explored (Area). Response variables derived from accelerometers included daily percentage motion (%Act) and cumulative activity data (CumAct). All variables were grouped into six consecutive weekly periods and analyzed by a repeated measures mixed model that included the fixed effects of BREED, WEEK, and the BREED*WEEK interaction in a completely randomized design. A significant (P< 0.01) BREED*WEEK interaction was detected on all GPS-derived variables, with RC exhibiting a trend to explore larger areas than BA (P=0.06). For the accelerometer-derived variables, the BREED*WEEK interaction was only significant (P=0.01) for CumAct. Overall, BA spent a larger percentage of the day active (%Act; BA= 76.74 vs. RC= 73.16; P=0.02), while investing a significantly greater overall activity (CumAct; BA= 8816.63 vs. RC= 6311.31; P=0.03) compared to RC cows. The insensitivity of GPS-derived variables is hypothesized to be the result of aggregating errors associated with less frequent GPS location measurements coupled with position errors (~5m) and a low success rate of data packet transmission (~40%). The spatial scale of the study is hypothesized to have influenced the foraging behavior differences that were observed between the breeds, and the better performance of the accelerometer vs. GPS-derived variables.
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Dobra, Gheorghe, Santiago Garcia-Granda, Adina Negrea, Mihaela Ciopec, Nicoleta Sorina Nemes, Petru Negrea, Narcis Duteanu, et al. "Silver Adsorption on the Low Temperature Activated Alumina Grades. II. Antimicrobial Activity of the Silver Adsorbed on the Alumina Surface." Revista de Chimie 73, no. 3 (July 29, 2022): 14–27. http://dx.doi.org/10.37358/rc.22.3.8531.
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The subject of this paper was the study of antimicrobial capacity of silver loaded on the low temperature activated alumina products and evaluation of these products as decontaminants in the water and waste waters decontamination treatments. The low temperature activated alumina products have been characterized as valuable adsorbents in previous papers. So, by reason the next step to investigate these silver loaded products and finding their performaces as antimicrobial agents was an alluring prospect. For this purpose, a common bacterian inoculus was choosen for experiments, and a penmisive method to measure the rate of inhibition was adopted. Experimental data have shown the dependence of the inhibition rate on the following parameters concerning the adsorbent properties: the thermal treatments, particle size dimension of adsorbent (low temperature activated alumina products), concentration of siver adsorbed on particle surface and density of bioreactive centers, representing the number of particles on unit volume of the liquid containing the bacterial cells. Also, the experiments lay out that the aluminum hydroxide calcined at 300 and 400ºC exibits the largest silver adsorbed concentration and the highest inhibition rate (close to 100 %). Little dependence of inhibition rate on pH, in the interval 5.0 � 8.0, was observed. For application of depolluting agent in diferent technological processes, it is necesary to measure the minimum inhibitory concentration in therms of g of silver loaded on the low temperature activated alumina /L.
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Sukumaran, Monikandon, Kesavan Devarayan, Ramar Marimuthu, and Sabariswaran Kandasamy. "Pre-During-Post Lockdown Air Quality in Adyar, Chennai, India Amid COVID-19 Pandemic." Revista de Chimie 72, no. 4 (October 29, 2021): 110–17. http://dx.doi.org/10.37358/rc.21.4.8461.
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The COVID-19 pandemic has shoved most of the countries to implement restrictions for transportation and all other social activities to minimize spread of disease to the people. India is the second most populated country in the world which has implemented a historical complete lockdown throughout the country from the last week of March to April 2020 with an extension up to the first week of May 2020. This lockdown has slowed down the pollution levels in most of the cities in India within the first few weeks of the lockdown. In this view, the present study discusses the air quality scenario of Chennai, one of the megacities of India, scientifically. With the aid of air quality data of the Tamil Nadu Pollution Control Board, India, for five parameters such as PM 2.5 and P.M 10, sulphur dioxide, nitrogen dioxide and air quality index, the authors correlated the pre-during-post lockdown air quality of Adyar, Chennai. The results indicated that the concentrations of particulate matter reduced to about 50 � 80 % during the lockdown compared to pre-lockdown. The concentrations of sulphur dioxide and nitrogen dioxide were decreased to 50% and 20%, respectively, within the first week of lockdown. Further the data were compared with the pollution data for the past two years (2018 and 2019). The present study gives insight on the reduction of pollution in proportion to the temporary control of pollution source at particular interval could rejuvenate the environment.
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Chavarría, C., M. J. Casanova, M. Chaparro, M. Barreiro-de Acosta, E. Ezquiaga, L. Bujanda, M. Rivero, et al. "Prevalence and Factors Associated With Fatigue in Patients With Inflammatory Bowel Disease: A Multicentre Study." Journal of Crohn's and Colitis 13, no. 8 (February 5, 2019): 996–1002. http://dx.doi.org/10.1093/ecco-jcc/jjz024.
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Abstract Background and Aims The aims of this study were to determine the prevalence of fatigue in patients with inflammatory bowel disease [IBD], to identify the factors associated with fatigue and its severity, to assess the impact of fatigue on quality of life [QoL], and to evaluate the relationship between fatigue and sleep disorders. Methods This was a prospective multicentre study conducted at 22 Spanish centres. Consecutive patients followed at IBD Units were included. Fatigue was evaluated with the Fatigue Severity Scale [FSS] and the Fatigue Impact Scale [FIS]. Quality of life and sleep quality were assessed using the IBD Questionnaire-Short Form [IBDQ-9] and the Pittsburgh Sleep Quality Index [PSQI], respectively. Results A total of 544 consecutive adult IBD patients were included [50% women, mean age 44 years, 61% Crohn’s disease]. The prevalence of fatigue was 41% (95% confidence interval [CI] = 37–45%). The variables associated with an increased risk of fatigue were: anxiety [OR = 2.5, 95% CI = 1.6–3.7], depression [OR = 2.4, 95% CI = 1.4–3.8], presence of extraintestinal manifestations [EIMs] [OR = 1.7, 95% CI = 1.1–2.6], and treatment with systemic steroids [OR = 2.8, 95% CI = 1.4–5.7]. The presence of EIMs [regression coefficient, RC = 8.2, 95% CI = 2.3–14.2], anxiety [RC = 25.8, 95% CI = 20.0–31.5], depression [RC = 30.6, 95% CI = 24.3–37.0], and sleep disturbances [RC = 15.0, 95% CI = 9.3–20.8] were associated with severity of fatigue. Patients with fatigue had a significantly decreased IBDQ-9 score [p < 0.001]. Conclusions The prevalence of fatigue in IBD patients is remarkably high and has a negative impact on QoL. Therapy with systemic steroids is associated with an increased risk of fatigue. The severity of fatigue is associated with anxiety, depression, sleep disorders, and the presence of EIMs. Fatigue was not associated with anaemia, disease activity or anti-TNF therapy.
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Ross, Brian D., Dariya Malyarenko, Kevin Heist, Ghoncheh Amouzandeh, Youngsoon Jang, Christopher A. Bonham, Cyrus Amirfazli, Gary D. Luker, and Thomas L. Chenevert. "Repeatability of Quantitative Magnetic Resonance Imaging Biomarkers in the Tibia Bone Marrow of a Murine Myelofibrosis Model." Tomography 9, no. 2 (February 28, 2023): 552–66. http://dx.doi.org/10.3390/tomography9020045.
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Quantitative MRI biomarkers are sought to replace painful and invasive sequential bone-marrow biopsies routinely used for myelofibrosis (MF) cancer monitoring and treatment assessment. Repeatability of MRI-based quantitative imaging biomarker (QIB) measurements was investigated for apparent diffusion coefficient (ADC), proton density fat fraction (PDFF), and magnetization transfer ratio (MTR) in a JAK2 V617F hematopoietic transplant model of MF. Repeatability coefficients (RCs) were determined for three defined tibia bone-marrow sections (2–9 mm; 10–12 mm; and 12.5–13.5 mm from the knee joint) across 15 diseased mice from 20–37 test-retest pairs. Scans were performed on consecutive days every two weeks for a period of 10 weeks starting 3–4 weeks after transplant. The mean RC with (95% confidence interval (CI)) for these sections, respectively, were for ADC: 0.037 (0.031, 0.050), 0.087 (0.069, 0.116), and 0.030 (0.022, 0.044) μm2/ms; for PDFF: 1.6 (1.3, 2.0), 15.5 (12.5, 20.2), and 25.5 (12.0, 33.0)%; and for MTR: 0.16 (0.14, 0.19), 0.11 (0.09, 0.15), and 0.09 (0.08, 0.15). Change-trend analysis of these QIBs identified a dynamic section within the mid-tibial bone marrow in which confident changes (exceeding RC) could be observed after a four-week interval between scans across all measured MRI-based QIBs. Our results demonstrate the capability to derive quantitative imaging metrics from mouse tibia bone marrow for monitoring significant longitudinal MF changes.
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Minato, Akinori, Hirotsugu Noguchi, Ikko Tomisaki, Atsushi Fukuda, Tatsuhiko Kubo, Toshiyuki Nakayama, and Naohiro Fujimoto. "Clinical Significance of Squamous Differentiation in Urothelial Carcinoma of the Bladder." Cancer Control 25, no. 1 (January 1, 2018): 107327481880026. http://dx.doi.org/10.1177/1073274818800269.
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The prognostic value of squamous differentiation (SD) in urothelial carcinoma (UC) of the bladder is unclear. The aim of this study was to identify the clinical significance of SD in UC in terms of oncological outcomes in patients undergoing radical cystectomy (RC). We evaluated consecutive patients with muscle-invasive bladder cancer (MIBC; clinical T2-4aN0M0) treated with RC at our institution from March 2003 to March 2017. We enrolled 20 and 81 patients with UC with SD (UCSD) and pure UC, respectively. Postoperative survival outcomes were compared between the patients with UCSD and pure UC using the Kaplan-Meier method. Pre- and postcystectomy factors that influenced the overall survival (OS) and recurrence-free survival (RFS) were investigated in these patients. Multivariate Cox regression models were used to identify the predictors of OS and RFS. With a median follow-up time of 31 months, the 5-year OS rate of the UCSD and pure UC groups was 41.1% and 69.7% ( P = .002) and the 5-year RFS rate was 51.8% and 59.5% ( P = .027), respectively. The shape of the Kaplan-Meier curves for UCSD suggested a more rapid course of the disease within the first 2 years than observed in pure UC. Multivariate analyses suggested that SD in UC was significantly associated with OS (hazard ratio [HR]: 4.22; 95% confidence interval [CI]: 1.20-14.8; P = .024) and close to significance for a lower RFS (HR: 2.13, 95% CI: 0.74-6.15, P = .064). Our results indicate that SD may be an independent predictor of OS and RFS in UC of MIBC in patients undergoing RC.
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Furnari, Laura, Ana Paula Vollet Cunha, Caroline Zeppelin dos Santos Emiliozzi, Caroline Castilhano Sampaio, Carlos Eduardo Bravin Maistro, Marcus Vinicius Saad de Paula Rodrigues, and Victor Augusto Bertotti Ribeiro. "Verificação das etapas de registro e delineamento em planejamentos de radiocirurgia estereotáxica." Revista Brasileira de Física Médica 16 (December 30, 2022): 695. http://dx.doi.org/10.29384/rbfm.2022.v16.19849001695.
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Alguns requisitos mínimos no processo da garantia da qualidade são necessários para a realização de tratamentos especiais, como a radiocirurgia estereotáxica (RC). Dentre alguns pontos de atenção, é possível citar: dosimetria de campos pequenos; validação do sistema de planejamento computadorizado (SPC); avaliação dos sistemas de IGRT; treinamento das equipes envolvidas; testes de ponta a ponta; definição dos controles da qualidade periódicos, entre outros. O objetivo desse trabalho, portanto, foi verificar as etapas de aquisição de imagens, registro e delineamento de estruturas em um planejamento de radiocirurgia, trazendo maior segurança ao processo. Foram adquiridas e inseridas no SPC iPlan as seguintes imagens do objeto simulador StereoPHAN da Sun Nuclear: de tomografia computadorizada, de ressonância magnética nuclear e imagens planares obtidas em um equipamento destinado a exames de angiografia. As imagens foram inspecionadas visualmente e quantitativamente, através de métricas, como o erro do registro-alvo (TRE), a avaliação das dimensões das cavidades internas do objeto simulador e as variações entre as bordas dos volumes delineados nas diferentes séries de imagens. Os resultados mostraram-se satisfatórios para a análise do TRE, sendo menor que o tamanho de um voxel no processo de fusão, a sobreposição do delineamento das esferas, não apresentou diferença nas bordas maior que 1 mm, porém os volumes calculados mostraram-se superiores para as esferas menores quando delineadas utilizando as imagens planares. Este fato está relacionado com o baixo contraste das imagens planares obtidas, fazendo com que o delineamento fosse um pouco maior que o esperado. Conclui-se, portanto, que o SPC utilizado apresenta-se íntegro e adequado para os processos testados em RC e o objeto simulador SteroPHAN contribuiu para uma verificação independente, mesmo a instituição já tendo controles estabelecidos de controle da qualidade para a prática de RC.
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Xia, Zhengyan, Chu Zhang, Haiyong Weng, Pengcheng Nie, and Yong He. "Sensitive Wavelengths Selection in Identification of Ophiopogon japonicus Based on Near-Infrared Hyperspectral Imaging Technology." International Journal of Analytical Chemistry 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/6018769.
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Hyperspectral imaging (HSI) technology has increasingly been applied as an analytical tool in fields of agricultural, food, and Traditional Chinese Medicine over the past few years. The HSI spectrum of a sample is typically achieved by a spectroradiometer at hundreds of wavelengths. In recent years, considerable effort has been made towards identifying wavelengths (variables) that contribute useful information. Wavelengths selection is a critical step in data analysis for Raman, NIRS, or HSI spectroscopy. In this study, the performances of 10 different wavelength selection methods for the discrimination of Ophiopogon japonicus of different origin were compared. The wavelength selection algorithms tested include successive projections algorithm (SPA), loading weights (LW), regression coefficients (RC), uninformative variable elimination (UVE), UVE-SPA, competitive adaptive reweighted sampling (CARS), interval partial least squares regression (iPLS), backward iPLS (BiPLS), forward iPLS (FiPLS), and genetic algorithms (GA-PLS). One linear technique (partial least squares-discriminant analysis) was established for the evaluation of identification. And a nonlinear calibration model, support vector machine (SVM), was also provided for comparison. The results indicate that wavelengths selection methods are tools to identify more concise and effective spectral data and play important roles in the multivariate analysis, which can be used for subsequent modeling analysis.
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Alejandro, Manuel, Amparo Roca, Gema Romero, and Jose Ramon Díaz. "How does the milk removal method affect teat tissue and teat recovery in dairy ewes?" Journal of Dairy Research 81, no. 3 (June 10, 2014): 350–57. http://dx.doi.org/10.1017/s0022029914000338.
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The aim of this work was to study how machine milking (MM) carried out in suitable conditions affects teat wall thickness and teat canal length and their return after milking to pre-milking conditions, in comparison with other milk extraction methods considered biological referents: lamb suckling (LS), milk removal by catheter (RC) and hand milking (HM). Three Latin square experiments were designed, using 11 ewes in the first experiment (LS), 13 in the second (RC) and 12 in the third (HM). Each of the Latin squares was divided into two periods: in the first, the left gland of each animal was machine milked and the corresponding treatment (LS, RC and HM) was applied to the right gland. Subsequently, in the second period the extraction methods were interchanged. During the experimental period, 4 sampling days were carried out (2 in each experimental period), where ultrasound scans were taken before (B) and immediately after milking (A) and at 1 (1 h), 2 (2 h), 3 (3 h), 4 (4 h), 6 (6 h), 8 (8 h) and 10 (10 h) hours after milking finished. Teat wall thickness (TWT), teat wall area (TWA), teat end area (TEWA) and teat canal length (TCL) were measured in all the ultrasound images. MM increased TWT after milking compared with RC. TWT, TWA, TEWA and TCL were lower (P<0·05) in HM than in MM. No significant differences (P>0·05) were found between LS and MM for any variable. The extraction method affected the recovery time of the variables, with total teat recovery at 6 h after RC and 4 h after HM. In the case of LS, the TEWA and TCL values were recovered sooner, as of 3 h. Teat recovery time after MM was similar to the extraction method with which it was compared in each experiment. Thus, considering the similar increase in wall thickness and their recovery time compared with the reference methods, it was concluded that machine milking, carried out in optimum conditions and respecting the time interval between milkings usually applied on sheep farms (8–12 h), would not affect teat integrity. Moreover, given the variability observed in teat thickness recovery time between the different experiments, further research should be carried out to study which factors intrinsic and extrinsic to the animal may affect the teat wall thickness and recovery time after machine milking.
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Raiter, Noam, Mats Junek, Ahmad Rahim, and Siraj Mithoowani. "Prognostic Value of Inflammatory Markers in Hospitalized COVID-19 Patients." Canadian Journal of General Internal Medicine 17, no. 2 (June 4, 2022): 33–37. http://dx.doi.org/10.22374/cjgim.v17i2.579.
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It is unclear whether D-dimer is a disease-specific marker for COVID-19 or part of the general inflammatory response alongside C-reactive protein (CRP) and other acute-phase reactants. We extracted data of patients hos-pitalized with COVID-19 for demographics, comorbidities, biochemical data, and outcomes. Using multivari-able logistic regression, the value of D-dimer in predicting intensive care unit (ICU) admission or mortality was measured. Of 1175 patients, 263 were admitted to the ICU and 226 died. CRP predicted both ICU admission and mortality [Odds ratios (ORs) with 95% confidence interval 1.01 (1.01–1.01) and 1.00 (1.00–1.01), respectively] but D-dimer was not predictive of either outcome [ORs 1.02 (0.97–1.06) and 0.99 (0.93–1.06)]. This suggests D-dimer levels are not independently predictive of COVID-19 severity or mortality. Our results confirm find-ings from smaller cohorts and demonstrate the inflammatory characteristics of COVID in the Canadian context. RésuméOn ne sait pas exactement si le D-dimère est un marqueur propre à la COVID-19 ou s’il fait partie de la réponse inflammatoire générale au même titre que la protéine C réactive et autres réactifs de phase aiguë. Nous avons extrait les données relatives aux caractéristiques démographiques, aux affections comorbides, aux analyses bio-chimiques et aux issues de patients hospitalisés en raison de la COVID-19. À l’aide d’une régression logistique multivariable, nous avons mesuré l’utilité du D-dimère dans la prédiction de l’admission à l’unité des soins intensifs (USI) ou de la mortalité. Sur 1175 patients, 263 ont été admis à l’USI et 226 sont décédés. La protéine C réactive a permis de prédire l’admission à l’USI (rapport de cotes [RC] = 1,01; intervalle de confiance [IC] à 95 % de 1,01 à 1,01) et la mortalité (RC = 1,00; IC à 95 % de 1,00 à 1,01), mais le D-dimère n’a pas permis de prédire l’une ou l’autre issue (RC = 1,02; IC à 95 % de 0,97 à 1,06 pour l’admission à l’USI et RC = 0,99; IC à 95 % de 0,93 à 1,06 pour la mortalité). D’après ces résultats, les taux de D-dimère ne sont pas des prédicteurs indépendants de la gravité de la COVID-19 ou de la mortalité. Nos résultats confirment les résultats de cohortes plus petites et démontrent les caractéristiques inflammatoires de la COVID-19 dans le contexte canadien.
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Hatserelia, Zurab. "The Role of Pelvic Lymphadenectomy in Organ-sparing Treatment of Muscule-invasive Bladder Cancer." Health of Man, no. 3 (September 30, 2021): 109–14. http://dx.doi.org/10.30841/2307-5090.3.2021.246218.
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Although radical cystectomy (RCE) with extended pelvic lymph node dissection (ePLND) is the standard of care for patients with muscule-invasive bladder cancer (MIBC), the rate of partial cystectomy (PCE) in the world remains quite high (7%). In particular, the organ-sparing approach can be chosen when it is impossible to perform RCE due to medical contraindications or at the request of the patient. Its advantages include less trauma, better functional results, no need for neocystoplasty, and a better quality of life than after RCE. Moreover, with adequate patient selection, the five-year survival after PCE corresponds to that after RCE. The high probability of metastatic/micrometastatic lesions in regional lymph nodes (LN) at the time of detection of MIBC is the basis for a combination of CE, PLND, chemotherapy, immunotherapy, radiotherapy. However, due to the lack of randomized trials on the subject, the optimal volume of PLND has not been determined to date. The objective: to evaluate the clinical efficacy and safety of standard PLND (sPLND) versus ePLND, in trimodal (combination with PCE and adjuvant chemotherapy – ACT) treatment of MIBC. Materials and methods. A retrospective analysis of the results of treatment of 48 patients with MIBC after PCE in combination with sPLND or ePLND and ACT at the Kyiv City Clinical Oncology Center and the Oncourology Clinic of the Institute of Urology of the National Academy of Medical Sciences of Ukraine from 2012 to 2019 was conducted. During sPLND groups of external/internal iliac and obturator LN were dissected, at ePLND (in addition to these groups) – general iliac and presacral. The main indicators of effectiveness: general and cancer specific survival, life expectancy, recurrence-free survival. Safety indicators: frequency and nature of postoperative complications. Inclusion criteria: diagnosis of MIBC, stage of primary tumor from T2 to T4a, use in the program of examination of computed tomography/magnetic resonance imaging with contrast, removal of primary tumor by PCE (resection of the bladder with a bipolar electric knife, retreating from the tumor 0.8– cm to healthy tissues), sPLND/ePLND, ACT. Exclusion criteria – the presence of distant metastases. Statistical analysis: the significance of intergroup differences was determined by Pearson’s test (χ2). Significance level 0.05. Results. The average age of patients (including 43 men and 5 women) in the general group was 62 years (mean age – 38-74 years). The distribution of patients by tumor location was as follows: lateral walls – 32 (66.7%), the bottom of the bladder – 16 (33.3%). According to the local spread of the tumor: T2a-T2b – 27 (56.25%), T3a-T3b – 17 (35.4%) T4a-T4b – 4 (8.3%). By histological type of tumor: transitional cell carcinoma – 39 (81.25%), adenocarcinoma – 5 (10.41%), squamous cell carcinoma – 4 (8.3%). By volume of PLND: standard – 29 (60.4%), extended – 19 (39.6%). The median follow-up was 29 months (12–42 months). By means of CT metastases in pelvic LN were detected in 8 (16.6%) patients. On average, 13 LN were removed. At sPLND the minimum volume of removal was 8 LN, at ePLND – 15 LN. In the group where PCE + sPLND + ACT was performed, metastatic LN lesions were present in 6 (20.7%) patients, in the group where PCE + ePLND + ACT – in 11 (57.9%). The number of affected LN was correspond to the depth of invasion of the primary tumor. In the group of PCE + sPLND + ACT, 80% of internal iliac LN were affected. In the group of PCE + ePLND + ACT in 63.6% of cases – general iliac LN and in 36.4% – general and obturator. ePLND on average prolonged the time of surgery by 40 minutes, but did not lead to an increase in the frequency of complications, and did not increase the duration of postoperative drainage. In the group, where ePLND was performed, the 5-year survival rate depended on the metastatic lesion of regional LN at the time of diagnosis: in the presence of metastases it was 30%, and in the absence – 62%. Patients with baseline metastatic LN lesion had a higher risk of tumor recurrence. Thus, in 7 (14.5%) of them there was a local recurrence (on average within 16 months after surgery), in 5 (10.4%) – distant metastases, in 2 (4.16%) – their combination. The most common postoperative complication in both groups was lymphorrhea, but more often after ePLND than after sPLND: 42.1% vs. 17.2%. The second most common complications were pyelonephritis (occurring in 10.5% and 6.9%, respectively) and hydronephrosis (occurring in 10.5% and 6.9%, respectively, between 30 and 90 days after ureteral reimplantation). Dynamic intestinal obstruction – 1 (5.2%) was registered least often (only in the ePLND group). Conclusion. PCE in combination with PLND and ACT is a trimodal treatment of choice in MIBC patients, which allows to achieve fairly high 5-year survival (up to 60% in the absence of metastases) with better functional results (preservation of urinary function) and less trauma than with RC. The choice of PLND volume (standard or extended) should be determined by TNM stage, and the likelihood of developing lymphorrhea/lymphostasis. In the absence of a deep invasion of the bladder wall and metastases to common iliac and presacral LN, preference should be given to sPLND, as it is associated with a lower risk of lymphorrhea (twice lower than with ePLND). Further MIBC studies are needed to most effectively stratify patients for a particular treatment regimen.
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Li, Rong, Yanqing Liu, Tong Xu, Haijiao Zhao, Jingya Hou, Yun Wu, and Dongmei Zhang. "The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis." BioMed Research International 2019 (July 25, 2019): 1–14. http://dx.doi.org/10.1155/2019/2587245.
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Background. To improve the efficacy of regenerative treatment for gingival recessions, the autologous platelet concentrates (APCs) combined with coronally advanced flap (CAF) have been investigated. However, few studies systematically assess the complementary effect of APCs in periodontal regeneration. The present study aims to evaluate the additional effect of different types of APCs to CAF in the treatment of gingival recessions. Methods. Electronic databases (EMBASE, MEDLINE, and Cochrane Central Register of Controlled Trails) and relevant journals were searched until May 15, 2019. Only randomized controlled trials (RCTs) in English were included. Outcome variables include root coverage (RC), recession depth (RD), clinical attachment level (CAL), keratinized tissue width (KTW), and gingival thickness (GT). Data were analyzed with Revman5.3. The estimate of effect sizes was expressed as the mean differences and the 95% confidence interval. Results. 8 RCTs involving 170 patients (328 sites) were included. Our meta-analysis indicated RC, RD, CAL, KTW, and GT were better improved in the CAF plus APCs groups than the CAF alone. The subgroup analyses revealed that platelet-rich fibrin (PRF) brought significant improvement in RC, RD, CAL, and GT. Concentrated growth factors (CGF) lead clinic beneficial in CAL, KTW, and GT. No significant effect of platelet-rich plasma (PRP) could be found in any clinical parameters when combined with CAF. Conclusions. PRF could exert additional effect to CAF; the preferred treatment for gingival recessions was considered. Based on the limited studies, it seemed that PRP failed to show any additional effect and it was not suggested for gingival recessions. Given the limited research and high risk of bias, it is still needed to confirm the additional effect of CGF by more high-quality studies.
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Krajewski, Wojciech, Łukasz Nowak, Marco Moschini, Sławomir Poletajew, Joanna Chorbińska, Andrea Necchi, Francesco Montorsi, et al. "Impact of Adjuvant Chemotherapy on Survival of Patients with Advanced Residual Disease at Radical Cystectomy following Neoadjuvant Chemotherapy: Systematic Review and Meta-Analysis." Journal of Clinical Medicine 10, no. 4 (February 8, 2021): 651. http://dx.doi.org/10.3390/jcm10040651.
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Background: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) with pelvic lymph-node dissection is the standard treatment for cT2-4a cN0 cM0 muscle-invasive bladder cancer (MIBC). Despite the significant improvement of primary-tumor downstaging with NAC, up to 50% of patients are eventually found to have advanced residual disease (pT3–T4 and/or histopathologically confirmed nodal metastases (pN+)) at RC. Currently, there is no established standard of care in such cases. The aim of this systematic review and meta-analysis was to assess differences in survival rates between patients with pT3–T4 and/or pN+ MIBC who received NAC and surgery followed by adjuvant chemotherapy (AC), and patients without AC. Materials and Methods: A systematic search was conducted in accordance with the PRISMA statement using the Medline, Embase, and Cochrane Library databases. The last search was performed on 12 November 2020. The primary end point was overall survival (OS) and the secondary end point was disease-specific survival (DSS). Results: We identified 2124 articles, of which 6 were selected for qualitative and quantitative analyses. Of a total of 3096 participants in the included articles, 2355 (76.1%) were in the surveillance group and 741 (23.9%) received AC. The use of AC was associated with significantly better OS (hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.75–0.94; p = 0.002) and DSS (HR 0.56, 95% CI 0.32–0.99; p = 0.05). Contrary to the main analysis, in the subgroup analysis including only patients with pN+, AC was not significantly associated with better OS compared to the surveillance group (HR 0.89, 95% CI 0.58–1.35; p = 0.58). Conclusions: The administration of AC in patients with MIBC and pT3–T4 residual disease after NAC might have a positive impact on OS and DSS. However, this may not apply to N+ patients.