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Shiner, Nancy Power. "In the best interest of the service, RCAF flight nurses as the new woman, 1945-1959." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0010/MQ36531.pdf.
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Slade, Anthony Lynn. "Designing, Debugging, and Deploying Configurable Computing Machine-based Applications Using Reconfigurable Computing Application Frameworks." Diss., CLICK HERE for online access, 2003. http://contentdm.lib.byu.edu/ETD/image/etd186.pdf.
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Serrano, Candelas Eva 1982. "Phylogenomic analysis and genomic structure of human RCAN genes : Effect on RCAN overexpression on lymphocyte development and function." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/128944.
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The protein phosphatase calcineurin (Cn), together with its substrates, the
transcription factors NFATc, play an essential role in several physiological
processes of vertebrates, such as the immune response, angiogenesis,
morphogenesis of the heart valves and neural and muscle development.
Concretely in the immune system, the Cn-NFATc signaling pathway is crucial in the
generation of T cell repertory in the thymus and in several processes of mature T
lymphocytes, as T cell activation and survival. The members of the Regulators of
Calcineurin (RCAN) family interact with Cn and compete with NFATc transcription
factors for binding to Cn. RCANs can act either promoting or suppressing Cn
activity towards its substrates. Due to their capacity to negatively modulate Cn-
NFATc signaling, RCAN proteins are considered as potential immunosuppressant
proteins. The aim of the present work was to deepen in the physiological
processes that regulate the expression of RCAN and to evaluate the effect of their
overexpression in the immune system. To this end, we have analyzed the
evolution of RCAN genes and the genomic structure of the three human members
of the RCAN gene family and, more specifically, the regulation of RCAN3 gene
expression. Furthermore, we have evaluated the expression pattern of the
different mouse Rcan genes in lymphoid tissues, and we have analyzed the in vivo
relevance of RCAN1 and RCAN3 overexpression in T cell development and
function. In this context, RCAN1 and RCAN3 overexpression enhances positive
selection of thymocytes. Moreover, RCAN1 overexpression increases the
generation of nTregs in thymus and seem to influence the effector/memory T cells
proportion in homeostasis. Furthermore, RCAN proteins appear to modulate
other TCR signaling pathways different than Cn-NFATc. Therefore, RCAN proteins
are important players of in vivo T cell development, differentiation and activation.La fosfatasa calcineurina (Cn), junto con sus substratos, los factores de transcripción NFATc, juega un papel esencial en varios procesos fisiológicos de vertebrados, como la respuesta inmune, la angiogénesis, la morfogénesis de las válvulas cardíacas o el desarrollo neuronal y muscular. Concretamente en el sistema inmune, la vía de señalización celular Cn-NFATc es crucial en la generación del repertorio de células T en el timo y en varios procesos de la función de los linfocitos T maduros, como la activación y la supervivencia de las células T. Los miembros de la familia de Reguladores de Calcineurina (RCAN) interaccionan con Cn y compiten con los factores de transcripción NFATc por su unión a Cn. Las RCAN pueden actuar promoviendo o inhibiendo la vía de Cn sobre sus sustratos. Debido a esta capacidad de regular negativamente la vía de señalización Cn- NFATc, las proteínas RCAN son consideradas como proteínas potencialmente inmunosupresoras. El objetivo del presente trabajo ha sido profundizar en los procesos fisiológicos que regulan la expresión de los genes RCAN y evaluar el efecto de su sobrexpresión en el sistema inmune. Con este fin, hemos analizado la evolución de los genes RCAN y la estructura genómica de los tres miembros RCAN en humanos y, más específicamente, la regulación de la expresión génica de RCAN3. Asimismo, hemos examinado el patrón de expresión de los diferentes genes Rcan de ratón en tejidos linfoides y hemos analizado la relevancia in vivo de la sobrexpresión de RCAN1 y RCAN3 en el desarrollo y la función de las células T. En este contexto, la sobrexpresión de RCAN1 y de RCAN3 induce la selección positiva de timocitos. Además, la sobrexpresión de RCAN1 aumenta la generación de células nTregs en timo y parece influir en la proporción de células T efectoras/memoria en homeostasis. Asimismo, las proteínas RCAN parecen modular otras vías de señalización dependientes del TCR diferentes a la vía Cn- NFATc. Por tanto, las proteínas RCAN son agentes importantes en el desarrollo, la diferenciación y la activación de células T.
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Freitas, Valeska Rodriguez Lucas de. "RCA : resource consumptions accounting." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/72263.
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Devido à grande concorrência do mercado o controle de custos passa a ser peça fundamental no auxílio à tomada de decisão quanto à redução dos custos, visando uma lucratividade maior por parte das empresas. Essa dissertação trata sobre um novo modelo de custos, o RCA – Resource Consumption Accounting, que ainda não foi adotado por nenhuma empresa. Esse novo método de custeio foi aplicado como modelo piloto em uma empresa Americana onde os resultados foram favoráveis a ele em relação aos modelos existentes. Muitos autores defendem o RCA como sendo um grande aliado aos gestores e ao setor financeiro por ser de fácil entendimento, apurar a capacidade ociosa e principalmente por apurar os custos com maior precisão em relação aos métodos mais utilizados atualmente. O RCA deve superar ao método ABC – Activity Based Costing, pois ele possui algumas vantagens em relação a este, por exemplo, como tratar separadamente os custos fixos dos variáveis, evitando assim rateios arbitrários e gerando uma apuração dos custos dos produtos e das atividades com maior precisão, além de apurar a capacidade ociosa, auxiliando assim os gestores na tomada de decisão. O RCA, assim como o ABC, é caro de ser implantado, pois precisa ser utilizado junto com sistemas integrados, sendo a sua principal desvantagem.Due to market competition, the cost control becomes a critical tool to assist managers in taking decisions pursuing the cost reduction improving the companies profitability. This dissertation is about a new cost management system, the RCA - Resource Consumption Accounting, which has not been adopted yet by any company. This new cost management system was applied as a pilot model for an American company and the results were favorable to him. Many authors support RCA as a great ally to managers and financial managers because it is easy to understand, work with embedded systems, and determine the idle capacity mainly determine costs with greater accuracy compared with the methods currently used. The RCA must overcome to ABC - Activity Based Costing, because presents some advantages over this, for example, treat separately the fixed costs of the variable ones, avoiding arbitrary apportionments and generating a calculation of the costs of products and activities more accurately, also determine the idle capacity, thereby assisting managers in taking decision. The RCA, as ABC, is expensive to deploy because it must be used with integrated systems, being its main disadvantage.
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Nordström, Maria. "Estimation of gusty winds in RCA." Thesis, Uppsala universitet, Luft-, vatten och landskapslära, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303867.
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In this study a new wind gust estimate (WGE) method proposed by Brasseur (2001) is implemented in a limited area climate model (RCA, Rossby Centre regional Atmospheric model). The WGE method assumes that wind gusts develop when air parcels higher up in the boundary layer deflect down to the surface by turbulent eddies. The method also gives an interval of possible gusts by estimating an upper and lower bound of a bounding interval. Two separate storms (December 3-4, 1999 and January 8-9, 2005) and a three month period (November 1, 2004 - January 31, 2005) are simulated with RCA. The results are compared to direct observations and to gridded analysis (MESAN). The result is highly dependent on how well the meteorological fields are represented in RCA. Since the storm of December 1999 was not well captured by RCA, the wind gusts were consequently not correctly estimated. The storm of January 2005 was well captured by the RCA and the wind gusts relatively well described. Both the storm of January 2005 and the simulation over a three month period give rather good estimated gusts over sea areas, while over land there is an obvious overestimation of the calculated gusts. A correction to the estimated gust is necessary in order to make the parameterisation useful. Such a correction is tested in this study. It shows significant improvement over most land areas and also gives a certain underestimation in other areas.Sammanfattning av ”Beräkning av byiga vindar i RCA” En ny metod (WGE-metoden) för att bestämma byvindar har i den här studien implementerats i en regional klimatmodell (RCA, Rossby Centre regional Atmospheric model). WGE-metoden utgår från att vindbyar genereras när luftpaket högre upp i gränsskiktet förs ner till marken av stora turbulenta virvlar. Ett intervall av möjliga byvindar erhålls genom att en övre och undre gräns för detta intervall beräknas. Två stormar (3-4 december 1999 och 8-9 januari 2005) och en tremånaders period (1 november 2004 – 31 januari 2005) har simulerats, och resultaten har jämförts med mätdata och MESAN. Resultatet är till stor del beroende av hur väl de meteorologiska fälten representeras av RCA. Stormen i december 1999 simulerades dåligt av RCA, vilket medförde att byvinden inte heller simulerades korrekt. Både stormen januari 2005 och simuleringen över tre månader ger en tämligen korrekt byvind över hav, samtidigt som man över land får kraftiga överskattningar av den beräknade byvinden. För att byvind-parametriseringen ska vara användbar krävs korrigeringar för att komma till rätta med överskattningen över land. En korrigering testades i den här studien med resultatet att ett förbättrat resultat över land samtidigt leder till en viss underskattning av byvinden i andra områden.
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Biradar, Megha. "Improvement of RCA initiation on genomic DNA." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256513.
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Schenk-Weibhauser, Katharina. "Etablierung der RCAS-Gentransfertechnologie zur Durchführung funktionell-genomischer Studien beim Haushuhn." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-105409.
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Zielke, Norman. "Functional analysis of the cell cycle regulator Rca1 in Drosophila melanogaster." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=983176388.
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Olson, Ted. "Recording Review of Nilsson, The RCA Albums Collection." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/1166.
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Grosskortenhaus, Ruth. "Charakterisierung der Zellzyklusfunktion von rca1 (regulator of cyclin A) in Drosophila melanogaster." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964147335.
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Geiger, Anna. "Semiquantitativer Vergleich zweier unterschiedlicher Kollimationsverfahren in der zerebralen Perfusionsszintigraphie mittels rCBF-SPECT /." [S.l.] : [s.n.], 2009. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Ricci, Pierbruno. "The Renal Cysts and Diabetes syndrome : from transcriptional profiling and functional analysis of a novel mouse model to biomarkers evaluation in human patients." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS111/document.
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Les mutations hétérozygotes du gène codant pour le facteur de transcription HNF1B sont à l'origine d'un syndrome multisystémique complexe connu sous le nom de « Renal Cysts and Diabetes » (RCAD). Un modèle de souris généré dans notre laboratoire s'est avéré reproduire plusieurs caractéristiques de la maladie humaine. Nous avons réalisé un séquençage ARNm-microARN à différents stades de développement (E14,5 ; E15,5 ; E17,5) de ce modèle. Nous avons montré que les gènes les plus dérégulés étaient impliqués dans les processus métaboliques de transport, de lipides et d’acides organiques et étaient exprimés dans les tubules proximaux et, dans une moindre mesure, dans l’anse de Henlé et les canaux collecteurs. Nous avons sélectionné quatre microARN (miR-802, 194-2, 192 et -30a), régulés à la baisse et potentiellement contrôlés par HNF1B. Des expériences de transactivation de gène rapporteur dans des cellules HEK-293 ont montré que HNF1B était capable de transactiver la transcription de ces microARN via des sites de liaison présents dans les séquences régulatrices de ces gènes. En utilisant des microARN MIMICS nous avons par la suite montré que mir-802, mir-194-2 et mir-192 étaient capables d'inhiber l’expression d’un gène rapporteur contenant la région 3'UTR de HNF1B. L'analyse d'échantillons d'urine de 22 patients RCAD et de 22 contrôles sains a permis d'identifier 146 peptides excrétés de manière différentielle et associés au syndrome. En utilisant ces résultats dans un modèle mathématique, classificateur prédit efficacement le syndrome RCAD avec une sensibilité de 91.7% et une spécificité de 91.1% sur une large population de patientsHeterozygous mutations in the gene encoding the transcription factor HNF1B are the cause of a complex multisystem syndrome known as Renal Cysts And Diabetes (RCAD). A mouse model generated in our laboratory was shown to reproduce several features of the human disease. We performed high-throughput mRNA-microRNA sequencing at different developmental stages (E14.5, E15.5, E17.5). We showed that the most down-regulated genes were involved in transport, lipid and organic acid metabolic processes and expressed in proximal tubules and to a lesser extent in the loop of Henle and collecting ducts. We then selected four microRNAs (mir-802, 194-2, 192 and -30a), which were down-regulated and potentially controlled by HNF1B. Luciferase assays in HEK-293 cells showed that HNF1B was able to specifically transactivate in a dose response mode these microRNAs through binding HNF1B-binding sites in their regulatory promoter/enhancer upstream sequences. We subsequently showed by luciferase assays using miRNA MIMICS that mir-802, mir-194-2 and mir-192 were able to inhibit luciferase vectors containing the 3’UTR of Hnf1b. Analysis of urine samples from 22 RCAD patients and 22 healthy controls led to the identification of 146 peptides differentially excreted and associated with RCAD including a similarity regarding collagen and uromodulin fragments with the RCAD mouse model. Combining the peptides into a mathematical model we used independent cohorts of patients to validate the prediction of the RCAD syndrome. Our classifier efficiently predicted RCAD syndrome with 91.7% sensitivity and 91.1% specificity on a wide population
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Gogu, Ada. "Dimensionnement des réseaux RCSF sous des contraintes énergétiques : modèles mathématiques et méthodes d'optimisation." Compiègne, 2012. http://www.theses.fr/2012COMP2028.
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Dans cette thèse, nous nous sommes intéressés à la résolution exacte de problèmes de dimensionnement de réseaux RCSF, rencontrés pendant la phase de planification. Tout d’abord nous nous intéressons au problème de déploiement. Il s’agit de positionner les capteurs dans un plan euclidien afin de minimiser le coût des opérations de communication pour transmettre les données vers le Station de Base. Le deuxième problème, le problème de configuration de réseau, s’intéresse à l’organisation des capteurs dans des zones/clusters. L’objectif ici est de déterminer le nombre optimal de zones et leurs portées respectives afin de minimiser la consommation en énergie de chaque capteur. Les méthodes proposées sont basées sur des algorithmes de programmation dynamique qui garantissent des solutions optimales et sont à faible complexité si on les compare aux approches de littérature. Le dernier problème étudié concerne l’affectation de puissances aux capteurs et d’ordonnancement des transmissions. Ici l’objectif est de garantir les transmissions concurrentes entre les nœuds tout en minimisant le temps de transmission des données. Au cœur de notre approche est la stratégie d’affectation de puissances de transmissions qui tente de maximiser la valeur minimale de SINR estimée chez les récepteurs. Le problème est modélisé et résolu en utilisant un algorithme itératif basé sur la programmation linéaireIn this thesis, we focused on the development of optimal methods regarding WSN dimensioning problems, mostly encountered during the planning phase. These were instantiated basically into three combinatorial optimization problems. The network deployment scheme which seeks to place the sensors in a such way that the cost of communication operations is minimized. The network configuration problem that asks to find a strategy for dividing the network such that some criteria are satisfied. In the problem’s model we took into account the data aggregation constraint and the discrete values of power transmission. For both problems we proposed a resolution method, based on dynamic programming, which permitted us to solve them optimally. Finally, the joint problem of scheduling and power assignment, consisted in finding a feasible scheduling under SINR constraints and a power assignment scheme to guarantee successful concurrent transmissions. As the problem is shown to be NP-hard we propose a greedy heuristic. The resolution method for the power assignment strategy, an iterative algorithm based on linear programming, provides optimal solutions
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Movassaghi, Ramtin. "Durability of Reinforced Concrete Incorporating Recycled Concrete as Aggregate(RCA)." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2884.
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Abstract, The interest in using recycled construction materials is derived from the growth in construction and demolition waste due to rehabilitation and natural and technological disasters. The driving force for recycling concrete is three-fold: preserving natural resources, utilizing the growing waste and saving energy and money. While some waste concrete is currently being crushed and used for grading and base material for highways, it has not been used as the aggregate in new concrete in Canada, largely because of the plentiful supply of good quality virgin material. However, crushed concrete is being used in new concrete in other parts of the world where the local aggregate is inferior, and there is now a push within the Canadian cement and concrete sector to improve the industry sustainability, one aspect of which is recycling of materials.
The research done to date has emphasized the influence of recycled concrete aggregate (RCA) on the workability and strength of the new concrete with little attention being paid to the behaviour in service. In contrast, the present study is focused on the durability of concrete containing RCA in reinforced structures. Since the most common cause of failure of reinforced concrete structures in this part of the world is corrosion of the reinforcement by de-icing salts, the focus of the project is on this aspect of durability. The project involves a comparative study of the durability of three concrete mixtures containing, as coarse aggregate:
- new clean recycled concrete aggregate (NC-RCA) obtained by crushing the excess concrete returned to the ready mix yard;
- old de-icing salt contaminated, recycled concrete aggregate ( OC-RCA) from a demolished bridge over Highway 401 in Ontario;
- natural aggregate as a control material.
The electrochemical corrosion behaviour of the steel was monitored using linear polarization resistance and cyclic polarization techniques. In addition, the physical properties of the materials were assessed. For the aggregates, water absorption, chloride content and susceptibility to abrasion were determined. For the concretes, compressive strength, salt scaling resistance and chloride permeability were measured and microscopic observation of the interfacial zones between the aggregate and the new cement paste were conducted.
On the basis of the results, it is concluded that the durability and the strength of the RCA concrete is very dependent on the age of the RCA aggregate. Water and chloride permeability, and, salt scaling and reinforcing steel corrosion resistance of concrete made with a very well hardened old RCA were comparable with or better than those of in normal concrete. Concrete incorporating new RCA exhibited inferior properties and consequently, it is recommended that, the OC-RCA concrete can be used as a sustainable material in structural applications.
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Nishinari, Katsuhiro, Satoshi Kokubo, and Kazuhiro Yamamoto. "Simulation for pedestrian dynamics by real-coded cellular automata (RCA)." Elsevier, 2007. http://hdl.handle.net/2237/20045.
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Johnson, Charlene Cara 1966. "Effects of RCA cleaning upon breakdown voltages of thin gate oxides." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/277835.
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The purpose of this thesis was to investigate the effects of pre- and post-oxidation RCA cleaning on thin gate oxides through the study of breakdown voltages at several current levels. The RCA Clean consisted of SC1 (NH₄OH in H₂O₂), followed by an optional dilute HF dip, followed by SC2 (HCl in H₂O₂). SAS analysis of the experiments revealed the following results: an HF dip was not found to affect the performance of the pre-oxidation clean, SC2 was harmful to the oxide when performed after oxide growth, and the role of solution age was not clear. In addition, an interaction was found between SC1 and SC2 performed after oxide growth, with SC1 partially alleviating the harmful effects of SC2 when performed prior to SC2. This and other data led to the conclusion that SC2 was selectively etching the oxide.
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Genßler, Paul Richard. "Virtualisation of FPGA-Resources for Concurrent User Designs Employing Partial Dynamic Reconfiguration." Thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-191286.
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Reconfigurable hardware in a cloud environment is a power efficient way to increase the processing power of future data centers beyond today\'s maximum.
This work enhances an existing framework to support concurrent users on a virtualized reconfigurable FPGA resource. The FPGAs are used to provide a flexible, fast and very efficient platform for the user who has access through a simple cloud based interface.
A fast partial reconfiguration is achieved through the ICAP combined with a PCIe connection and a combination of custom and TCL scripts to control the tool flow.
This allows for a reconfiguration of a user space on a FPGA in a few milliseconds while providing a simple single-action interface to the user.
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Beringer, Danielle Nicole. "An Exploratory Study Investigating the Time Duration of Slip-Induced Changes in Gait." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/23079.
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The biomechanics of slips are commonly studied in laboratory settings in an effort to improve the understanding of slip mechanisms for the advancement of slip and fall prevention strategies and risk assessment methods. Prior studies have shown changes in gait after slipping, and these changes can reduce the external validity of experimental results. As such, most researchers only slip participants one time. The ability to slip participants more than once, after allowing gait to return to a natural baseline, would improve the experimental efficiency of these studies. Therefore, the goal of this study was to determine the time duration of slip-induced changes in gait. The required coefficient of friction (RCOF), a parameter highly predictive of risk of slipping, was measured on thirty-one young male adults during level gait on three separate days before slipping, immediately (<10 minutes) after slipping, and either one, two, four, or six weeks later. On average, the RCOF decreased 12% from its baseline value (0.20) after slipping, indicating the adoption of a protective gait with a decreased risk of slipping. The RCOF data trended toward baseline values 4-6 weeks after the slip experience, but remained statistically different from baseline. This indicates that the slip-induced gait alterations have long-lasting effects, enduring up to six weeks after the slip experience.Master of Science
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Frank, Martina [Verfasser], and Frank [Akademischer Betreuer] Sprenger. "Analyse der F-box Funktion von Rca1 in Drosophila melanogaster / Martina Frank. Betreuer: Frank Sprenger." Regensburg : Universitätsbibliothek Regensburg, 2015. http://d-nb.info/1065445288/34.
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Aoudia, Hania. "Approches de routage adaptatif pour l'optimisation de la consommation énergétique dans les applications type RCSF." Thesis, Paris 8, 2015. http://www.theses.fr/2015PA080077/document.
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La gestion de la consommation énergétique est une question incontournable lors la conception et la mise en œuvre d’un RCSF. Garantir un fonctionnement efficace avec un accroissement de la longévité du réseau en se limitant uniquement à une solution matérielle reste insuffisant. Il est donc nécessaire de se tourner vers d’autres solutions logicielles qui permettraient de maitriser l’exploitation de l’information dès sa source jusqu’à son acheminement vers sa destination finale en tenant compte des caractéristiques intrinsèques des capteurs, i.e., faibles capacités de stockage et de puissance de calcul, et contraintes énergétiques associées. Répondre en partie à ces besoins, passe par le développement d’outils informatiques et de stratégies protocolaires en modes basse consommation mettant en œuvre des mécanismes basés sur des techniques de routage d’informations. Dans cette thèse, nous proposons deux solutions protocolaires hiérarchisées HHRP et HRP-DCM. La première met en œuvre un mécanisme de routage adaptatif à base d’un modèle énergétique non linéaire et d’un concept de communication Fils-Parent pour la sélection des meilleurs chemins en tenant compte d’un ensemble de paramètres critiques tels que les distances source-cible, la puissance du signal et l’énergie consommée. Or, la phase de reconnaissance du voisinage nécessite l’utilisation de la puissance des signaux radio pour estimer les distances entre nœuds capteurs, ce qui est un inconvénient majeur puisque cela peut engendrer des dégradations sur les performances du routage et des erreurs d’estimation des mesures RSSI. Ces dernières ne sont exploitables pour la localisation des nœuds qu’au bout d’un certain temps vu que la stabilité du signal n’est garantie que tardivement. Ainsi, le temps alloué pour la phase de reconnaissance devient important, accélérant de ce fait la consommation d’énergie et donc minimise la durée de vie du réseau. Pour y remédier, nous proposons une alternative qui contourne l’utilisation de la puissance du signal RSSI à tous les niveaux du mécanisme en mettant en œuvre une approche de routage hybride basée sur un mécanisme de clusterisation dynamique HRP-DCM. Cette solution permet des améliorations non seulement lors de la phase de reconnaissance du réseau mais aussi sur l’optimisation des chemins lors de la communication. Elle utilise le concept de calcul des distances temporelles lors du déploiement du réseau ainsi les délais alloués à la phase d’initialisation sont raccourcis atténuant de fait la consommation énergétique et l’exploitation des ressources. L’évaluation des performances montre bien que HRP-DCM optimisent mieux le fonctionnement du réseau quelque soit sa densité comparativement à d’autres solutions telles que HHRP TEEN et LEACHManaging energy consumption is an unavoidable issue for a WSN design and implementation. Focusing lonely on a hardware solution to ensure an efficient of a running network while increasing its lifetime remains insufficient. It is therefore necessary to turn towards other software solutions that enable a better control of information processing from its source until its final destination by taking into account intrinsic characteristics of sensors, such as low storage and computing capabilities and associated energy constraints. A partial response to these needs requires the development of IT tools and protocolar strategies in low-power modes by implementing mechanisms based on information routing techniques. In this thesis, we propose and develop two hierarchized protocolar solutions HHRP and HRP-DCM. The first one implements an adaptive routing mechanism based on a nonlinear energy model and a concept of communication Son-Parent for a best paths selection by taking into account a set of critical parameters such as distance source-target, signal strength and energy consumption. However, the vicinity recognition phase requires the use of RSSI radio signals to estimate distances between sensor nodes. This can be considered as a major drawback since it may cause damage on routing performances and estimation error on RSSI measurements. These latters can be used for locating nodes only after a while since the stability of RSSI signal is guaranteed only belatedly Thus, the allocated time for recognition phase becomes significant, speeding up thereby energy consumption and thus reduces the lifetime of the network. In this context, we propose an alternative that bypasses the use of RSSI power signal in different levels of HHRP mechanism by implementing a hybrid routing approach based on a dynamic clustering mechanism HRP-DCM. This solution allows improvements in recognition and in paths optimization phases, both. It uses the concept of temporal distances calculation during network deployment. Thus, allocated time for network initialization is shortened mitigating in fact energy consumption and resources exploitation. Performance evaluation shows that HRP-DCM optimizes better network whatever its density compared to other solutions such as HHRP, TEEN and LEACH routing protocols
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Lange, Katharina. "Multidimensionale Darstellung der proximalen RCA in 3D4D- Technik im Vergleich zur Koronarangiographie." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-146506.
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Das Ziel der vorliegenden Studie war die Analyse der Detektierbarkeit von Stenosen und Lumenverschlüssen im proximalen Bereich der rechten Koronararterie mit konventioneller 2D- und 3D- Echokardiographie von transthorakal. Zusätzlich wurden die Befunde der 3D-Echoloops mit den Untersuchungsergebnissen der Koronarangiographie verglichen. Methodisch wurden daher bei Patienten mit bestehender Indikation zur Koronarangiographie vorhergehende zweidimensionale parasternale Lang- (n=91) und Kurzachsenaufnahmen (n=76), sowie parasternale dreidimensionale (n=91) echokardiographische Aufnahmen des Ostiums und der proximalen Region der rechten Herzkranzarterie durchgeführt. Durch zusätzliche Schnittebenen der proximalen Abschnitte der rechten Koronararterie sollte die konventionelle zweidimensionale Echokardiographie für eine Stenosendetektion ergänzt werden. Diese ermöglichten eine genaue Darstellung der rechtskoronaren Morphologie im proximalen Gefäßbereich. Maximal konnten die proximalen 35mm der rechten Koronararterie untersucht werden. Die Ergebnisse der einzelnen verschiedenen echokardiographischen Dokumentationen wurden miteinander und mit denen der Koronarangiographie verglichen. Insgesamt zeigten sich keine signifikanten Unterschiede zwischen den Ergebnissen der 2D Echokardiographie und der Koronarangiographie. Die Diameter der Streckenmessungen an der rechten Koronararterie in der 3D-Echokardiographie und der Koronarangiographie sind hingegen in ihren Mittelwerten signifikant verschieden. Dies ist durch häufigere Sekantenanschnitte der Gefäße mittels Echokardiographie bedingt. Die höchste Sensitivität konnte mittels 3D-Echokardiographie (98%) nachgewiesen werden, wohingegen die zweidimensionale Technik bessere Spezifitäten (91% in 2D-Langachsen- und 92% in 2D-Kurzachsen-Aufnahmen) aufweist. Diese Ergebnisse zeigen den Nutzen der Echokardiographie im klinischen Alltag zur intravasalen Stenosendetektion der rechten Koronararterie.
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Biandja, Jean. "Approche métallogénique du "Greenstone Belt" de Bogoin (RCA). Sa minéralisation en or." Phd thesis, Université Pierre et Marie Curie - Paris VI, 1988. http://tel.archives-ouvertes.fr/tel-01053229.
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La minéralisation aurifère primaire du secteur de Bogoin se présente sous forme d'un stockwerk quartzeux de direction N-S encaissé dans des roches vertes. Ces dernières appartiennent à une série métamorphique (limite faciès schistes verts-amphibolite) plissée en un synclinorium de direction N-S qui dessine un "doigt de gant" dans un vaste massif granito-gneissique. La foliation principale (SP) est plan axial de cette structure. L'ensemble est réputé archéen. Le synclinal s'ennoie vers le Sud sous une couverture gréso-quartzitique protérozoïque supérieur. Les granitoïdes sont en partie intrusifs dans la série métamorphique, comme le montrent des transformations endomorphiques au contact des roches vertes et des itabirites. Leur mise en place est anté-à syn-SP. Ils sont de type S et de caractère calco-alcalin. Des filonnets aplo-pegmatitiques marquent deux "migmatisations", l'une anté-à syn-SP, l'autre post-SP. La série métamorphique comprend, de bas en haut : Des roches vertes (amphibolites), des gneiss fins, des itabirites, une série rubanée volcano-sédimentaire couronnée par des métarhyolitoïdes de type calco-alcalin. Ces deux derniers termes n'avaient pas auparavant été décrits. Le magmatisme basique est de type tholéiitique et les faciès ultra basiques peuvent correspondre à des cumulats résultant du processus de cristallisation fractionnée. La découverte de tourmalinite dans le stockwerk aurifère montre l'intervention de fluides liés aux granitoïdes. Une première génération de de quartz gris renferme des sulfures (pyrrhotite destabilisée en melnicovite-marcasite, pyrite, mispickel, chalcopyrite) et l'essentiel de l'or libre. Une deuxième génération de quartz blanc est dépourvue de sulfures et renferme de faibles teneurs en or. Dans le secteur minéralisé, les roches vertes ont subi des altérations (chlorite, muscovite, trémolite-actinote, talc). Des anomalies en or existent dans les roches vertes altérées. La minéralisation de Bogoin présente un certain nombre de caractères correspondant au type "zone de cisaillement aurifère". Son cadre géologique correspond bien aux ceintures de roches vertes. Dans ce contexte, des concentrations aurifères peuvent être recherchées dans tous les termes lithologiques, notamment les itabirites et la série volcano-sédimentaire. (Centrafrique ; Or ; Précambrien ; Ceinture de roches vertes ; Zone de cisaillement ; Métallogénie ; Géochimie ; Magmatisme).
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Li, Lina. "Regulation and role of the complex response regulator RcaC during complementary chromatic adaptation in Fremyella diplosiphon." [Bloomington, Ind.] : Indiana University, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3219899.
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Thesis (Ph. D.)--Indiana University, Dept. of Biology, 2006."Title from dissertation home page (viewed June 28, 2007)." Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 2952. Adviser: David M. Kehoe.
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Kies, Matthias [Verfasser], Frank [Akademischer Betreuer] Sprenger, Michael [Akademischer Betreuer] Krahn, and Wolfgang [Akademischer Betreuer] Seufert. "Dual regulation of APC/C activity by Rca1 / Matthias Kies ; Frank Sprenger, Michael Krahn, Wolfgang Seufert." Regensburg : Universitätsbibliothek Regensburg, 2017. http://d-nb.info/1163108979/34.
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Zhang, Lei. "Molecular Regulation of Vascular Abnormalization and Its Role in Glioma." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248713.
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Glioblastoma, grade IV glioma, is the one of the deadliest cancers, with a median survival of only 12-15 months despite aggressive treatment including surgery, chemotherapy and radiation. One hallmark of glioblastoma is the morphological and functional abnormalization of tumor blood vessels. The molecular mechanisms involved in this process and their functional and pathological implications are not yet fully understood. Indentification of molecular mechanisms that underlie vascular abnormalization in GBM is necessary to develop efficient treatment regimens for normalizing vascular function. By analyzing the RNA-content of laser microdissected vessels from human biobank specimens using affymetrix microarray analysis, we found that the abnormal glioblastoma vessels have a distinct gene expression signature. We found 95 genes which were differentially expressed in grade IV glioma vessels as compared to vessels in low grade tumors and control brain. 78 of which were up-regulated while 17 were down-regulated. Many of these genes are regulated by VEGFA or TGFβ signaling. In addition, we show a significant increase in Smad signaling complexes in the vasculature of human glioblastoma in situ, suggesting that TGFβ signaling may play important role in vessel abnormalization. CD93 is a single-pass transmembrane glycoprotein, which we found to be up-regulated in high grade glioma. Vascular expression of CD93 correlates to tumor grade in human glioma. Moreover, high grade glioma patients with high CD93 expression in the vasculature are associate with poor prognosis. We found that knocking down CD93 in endothelial cells with siRNA clearly impaired endothelial cell adhesion, migration and tube formation due to defects in cytoskeletal rearrangement. In addition, tumor growth was severely delayed in the CD93-/- mice. Pleiotrophin, a multi-functional heparin-binding growth factor, promotes glioma growth in several ways. Here, we identify pleiotrophin as a driver of vascular abnormalization in glioma. We found that high pleiotrophin expression correlates with poor survival of patients with astrocytomas. Pleiotrophin overexpression in orthotopic GL261 gliomas increases microvessel density, enhances tumour growth and decreases survival. Vessels in pleiotrophin-expressing gliomas are poorly perfused and display a high degree of abnormality, coinciding with elevated levels of vascular endothelial growth factor (VEGF) deposited in direct proximity to the vasculature. In addition to its role in vessel abnormalization, pleiotrophin enhanced PDGF-B-induced gliomagenesis. Taken together, our results indicate that PTN has an important role in glioma initiation and establishment of the characteristic abnormal tumor vasculature in glioblastoma, identifying PTN as a potential target for therapy.
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CORIOLANO, Marília Calvacanti. "Purificação, caracterização e atividade imunomodulatória da lectina presente no soro do peixe beijupirá (Rachycentron canadum)." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/2240.
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Previous issue date: 2012Lectinas constituem um grupo heterogêneo de proteínas e glicoproteínas que se ligam especificamente a carboidratos com alta afinidade. O beijupirá, Rachycentron canadum, pertence à família Rachycentridae, e é uma espécie que reune as melhores condições para o cultivo de peixe marinho. Uma lectina foi purificada do soro do peixe Rachycentron canadum (RcaL) através de cromatografia de afinidade com uma coluna Concanavalina A-Sepharose 4B. Um pico com atividade dessa lectina foi Ca2+ (20 mM) dependente. RcaL é uma proteína com atividade em pH 7.0-8.0 e resistente a 40 ºC por 10 min. A lectina mostrou maior especificidade pelos açúcares metil-α-D-manopiranosídeo e D-manose (200 mM); frações cromatografadas de RcaL eluídas aglutinaram eritrócitos de coelho (AH: 128-1), mantiveram 66% da atividade da lectina purificada e o fator de purificação obtido foi 1.14. Sob condições redutoras, uma banda de 19.2 kDa foi revelada em SDS-PAGE. PAGE confirmou que RcaL é uma proteína ácida revelada em um única banda. Ensaios citotóxicos e imunomodulatórios com RcaL em culturas de esplenócitos de camundongos foram realizados e mostraram que a lectina não foi citotóxica e induziu alta produção de IFN- e óxido nítrico. Além disso, também foi avaliada a resposta proliferativa e a produção de citocinas em esplenócitos de camundongos in vitro estimulados com as lectinas RcaL e Con A. Os resultados demonstraram altos índices de proliferação induzidos por RcaL em relação às células controles e a Con A. RcaL induziu alta produção de IL-2 e IL-6 em relação ao controle. Somente apoptose tardia foi promovida pelo tratamento com RcaL em relação ao controle, em 24 horas de ensaio; RcaL e Con A promoveram também apoptose tardia em 48 horas de ensaio. No entanto, a viabilidade celular foi superior a 90% em esplenócitos tratados com RcaL. Os resultados mostraram que a lectina RcaL induz preferencialmente resposta imune Th1 sugerindo que ela atua como um composto imunomodulador e também induz resposta proliferativa, revelando que esta lectina pode ser usada como agente mitogênico em ensaios imunoestimulatórios
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Coriolano, Marília Cavalcanti. "Purificação, caracterização e atividade imunomodulatória da lectina presente no soro do peixe beijupirá (Rachycentron canadum)." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/12742.
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FACEPE
Lectinas constituem um grupo heterogêneo de proteínas e glicoproteínas que se ligam especificamente a carboidratos com alta afinidade. O beijupirá, Rachycentron canadum, pertence à família Rachycentridae, e é uma espécie que reune as melhores condições para o cultivo de peixe marinho. Uma lectina foi purificada do soro do peixe Rachycentron canadum (RcaL) através de cromatografia de afinidade com uma coluna Concanavalina A-Sepharose 4B. Um pico com atividade dessa lectina foi Ca2+ (20 mM) dependente. RcaL é uma proteína com atividade em pH 7.0-8.0 e resistente a 40 ºC por 10 min. A lectina mostrou maior especificidade pelos açúcares metil-α-D-manopiranosídeo e D-manose (200 mM); frações cromatografadas de RcaL eluídas aglutinaram eritrócitos de coelho (AH: 128-1), mantiveram 66% da atividade da lectina purificada e o fator de purificação obtido foi 1.14. Sob condições redutoras, uma banda de 19.2 kDa foi revelada em SDS-PAGE. PAGE confirmou que RcaL é uma proteína ácida revelada em um única banda. Ensaios citotóxicos e imunomodulatórios com RcaL em culturas de esplenócitos de camundongos foram realizados e mostraram que a lectina não foi citotóxica e induziu alta produção de IFN- e óxido nítrico. Além disso, também foi avaliada a resposta proliferativa e a produção de citocinas em esplenócitos de camundongos in vitro estimulados com as lectinas RcaL e Con A. Os resultados demonstraram altos índices de proliferação induzidos por RcaL em relação às células controles e a Con A. RcaL induziu alta produção de IL-2 e IL-6 em relação ao controle. Somente apoptose tardia foi promovida pelo tratamento com RcaL em relação ao controle, em 24 horas de ensaio; RcaL e Con A promoveram também apoptose tardia em 48 horas de ensaio. No entanto, a viabilidade celular foi superior a 90% em esplenócitos tratados com RcaL. Os resultados mostraram que a lectina RcaL induz preferencialmente resposta imune Th1 sugerindo que ela atua como um composto imunomodulador e também induz resposta proliferativa, revelando que esta lectina pode ser usada como agente mitogênico em ensaios imunoestimulatórios.
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Loeser, Edwards Francisco Javier. "Diferencias de los modelos de fiscalización ambiental de Proyectos con RCA y Proyectos sin RCA, análisis a partir de la fiscalización ambiental de faenas mineras de la Región de Antofagasta." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/159186.
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Memoria (licenciado en ciencias jurídicas y sociales)Este trabajo realiza una comparación de los dos modelos de fiscalización ambiental que conviven actualmente en Chile, en base a criterios cualitativos y cuantitativos, se pretende comparar la fiscalización ambiental de proyectos que cuentan con RCA favorable, con la fiscalización de proyectos que no cuentan con dicho instrumento de gestión. Este contraste, en primer lugar, se centra en el diseño formal de ambos modelos de fiscalización, en segundo lugar, se busca realizar un análisis práctico, por un lado, basándose en el estudio del estado actual de la fiscalización ambiental de faenas mineras dentro de la región de Antofagasta, por otro lado, dando cuenta de las principales críticas que han tenido ambos sistemas.
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Ahimoghadam, Faraz. "Effect of Recycled Concrete Aggregate Properties on the Behaviour of New Concrete." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37588.
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Application of recycled concrete aggregates (RCA) has increased recently as a sustainable alternative in concrete construction. Although application of RCA has substantially grown over the past decades, issues related to its structural performance and long-term behaviour still prevent its widespread application, especially in structural purposes. In this study, a new mixture proportioning method called the “Equivalent Volume (EV)” method is proposed for RCA concrete, which is developed on the assumption that the RCA mix is based on a companion conventional concrete mix having the same volume of “cement paste and aggregates” as the companion mixture. RCA mixes containing different aggregate types and mechanical properties were designed using the EV method. Chemical, mechanical and non-destructive tests were performed and their performance was investigated. Finally, a quality control protocol for evaluating the suitability of RCA sources for structural applications is proposed. Results show that the EV method seems a promising approach to mix-proportion eco-friendly recycled concrete mixes. Moreover, the RCA type and properties seem to influence in the behaviour of RCA concrete and thus should be accounted in the mix- design.
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Tisell, Camilla. "An investigation of the surface fluxes and other parameters inthe regional climate model RCA1 during ice conditions." Thesis, Uppsala universitet, Luft-, vatten och landskapslära, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303758.
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In this study data from the regional climate model RCA1 is compared to measured data to investigate how good the model is during ice conditions and mainly how well the turbulent surface fluxes are described by the model. Comparisons of the sensible heat flux and the momentum flux as well as mean parameters are included. The measured data used are from the Bothnian Bay measured during the BASIS field experiment in February to March 1998. RCA1 (Rossby Centre regional Atmospheric model) is a regional climate model for Northern Europe based on HIRLAM and forced by ERA-40 data. Two different grid points of the RCA1 44 km grid have been chosen with geographical coordinates as close as possible to the two measuring sites. The first site is a small peninsula south of the town Umeå at the east coast of Sweden and the second one is the ship R/V Aranda anchored in the sea ice outside the Finnish west coast. The model presents generally too large negative (downward) sensible heat fluxes and too large momentum fluxes over ice. The largest difference between modelled and measured sensible heat fluxes are seen after warm front passages due to melting conditions. There are some uncertainties in the comparison of modelled fluxes and measured fluxes at Umeå due to a complex and varying ice cover around this measuring site. The vertical structure in the atmosphere has also been studied and modelled temperature, wind and humidity profiles were compared to radiosondes at the Umeå site. Two periods with on-ice flow and off-ice flow was analysed and one of the main differences was that for the on-ice situation an internal boundary layer was built up over the ice. Modelled profiles are generally smoother then measured profiles and inversions and other small-scale phenomena like low-level jets are almost never described correctly by the model but there are tendencies of the phenomena to occur.Sammanfattning av ”En undersökning i hur bra den regionala klimatmodellen RCA1 beskriver olika parametrar över is, i huvudsak de turbulenta flödena”. I denna undersökning har den regionala klimatmodellen RCA1 jämförts med mätdata för att se hur bra modellen är över is och framförallt hur bra den beskriver de turbulenta flödena över is. RCA1 är en regional klimatmodell för norra Europa baserad på HIRLAM och som drivs av ERA-40 data. Modelldata har jämförts med mätdata från två platser i Bottenviken, en liten halvö utanför Umeå på den svenska östkusten och forskningsfartyget Aranda som var fastankrad i havsisen utanför Finlands västkust. Mätningarna gjordes under BASIS fältexperiment i februari till mars 1998. Modellen ger generellt för stora negativa (nedåtriktade) sensibla värmeflöden över is och likaså för stora impulsflöden över is. Den största skillnaden mellan modellvärden och mätningar förekom efter det att varmfronter passerat och detta beror delvis på smältförhållanden. I jämförelsen av de turbulenta flödena beräknade av RCA och de uppmäta turbulenta flödena från Umeå finns det vissa osäkerheter pga. den komplicerade issituationen runt denna mätplats med mycket varierande isförhållanden. Den vertikala strukturen i atmosfären har också undersökts och temperatur, vind och fuktighetsprofiler har jämförts. Två perioder varav en där det blåste från havet mot isen (on-ice) och en där det blåste från isen mot havet (off-ice) valdes ut och en av skillnaderna var att det bildades ett internt gränsskikt över isen i on-ice perioden. Modellen har en tendens att släta ut profilerna och småskaliga fenomen som inversionsskikt, inversionshöjder och low-level jets är nästan aldrig korrekt beskrivna i modellen men det finns tendenser till inversioner och vindmaximum.
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GARCIA, JÚNIOR Marcos Amarante. "Estudo das propriedades estatísticas e distribuição angular das flutuações de temperatura da RCF." reponame:Repositório Institucional da UNIFEI, 2012. http://repositorio.unifei.edu.br/xmlui/handle/123456789/1150.
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As flutuações de temperatura da radiação cósmica de fundo (RCF) contém informações importantes a respeito da estrutura e evolução do universo. Uma destas informações originou-se na ´época inflacionária e diz respeito a desvios de gaussianidade na distribuição estatística destas flutuações. O interesse em revelar as assinaturas desses desvios se deve ao fato que existem diversos modelos inflacionários que preveem tais desvios, assim, confirmar ou descartar a presença deles nos ajudará a conhecer a física do universo jovem. No entanto, existem várias fontes não cosmológicas de desvios de gaussianidade nos dados de flutuações de temperatura da RCF. Assim, ´e importante empregar um aferidor sensível o suficiente para detectar pequenos desvios de gaussianidade nos mapas da RCF. Neste trabalho testaremos como aferidor o coeficiente de Pearson. Nosso m´método consiste na aplicação deste aferidor nos dados da RCF do satélite WMAP-7 anos. Um procedimento semelhante ´e feito com um grande n´úmero de mapas Monte Carlo construídos segundo o modelo ΛCDM. A significância estatística de nossos resultados ´e estabelecida por comparação entre os dados do WMAP e os mapas Monte Carlo.
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Plym, Forshell Linus. "Assessment of therapeutic targets in experimental models of Myc-induced lymphoma." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46534.
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The Myc transcription factor activates expression of genes that promote cellular functions such as proliferation and cell growth. The deregulated Myc expression, characteristic for the tumor cell, also activates apoptosis, which selects for additional genetic changes deactivating the induced cell death. However, the continuous overexpression of Myc can also be a liability for a tumor, which can be taken advantage of in cancer treatment. In Paper I, we describe a new way of using the DNA methyltransferase inhibitor Decitabine, in treating Myc overexpressing tumors. We show that Decitabine treatment activates cell death by reactivating silenced tumor suppressors such as Puma, but also by inducing DNA damage. Decitabine treatment of Myc driven lymphomas is also shown to prolong disease free survival in mouse models. Myc driven transformation requires a collaborative deregulation of genes. The family of Pim kinases has been shown to collaborate with Myc in tumorigenesis. In Paper II, we show that the Pim-3 kinase protein is highly expressed in many Myc overexpressing lymphomas from Myc transgenic mice as well as human Burkitt Lymphoma samples. The Pim-3 locus is shown to interact with the Myc protein and be a direct target for Myc activated transcription. Additionally, we demonstrate that the Pim kinase inhibitor, Pimi, targeting the Pim kinase family (Pim-1, Pim-2 and Pim-3), induce a cell death that is mediated by, but not dependent on caspase activity. The Pimi induced cell death was potentiated when combined with RNAi knockdown of the casein kinase II (CK2) protein. In paper III, we describe the development of a somatic mouse model for lymphomagenesis, utilizing the RCAS-tva technology. We show that primary B cells from these mice are transducible and transformed when infected with a combination of RCAS- HA tagged Myc, KRasV12D and human Bcl-XL virus. In conclusion, we show that the labile milieu created by the deregulated expression of Myc facilitates new approaches in treatment of Myc overexpressing tumors. Also, our new tva mouse model show promise in modeling lymphomagenesis.
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Mbeko, Simaleko Marcel. "Efficacité d’interventions de prévention, basées sur une meilleure prise en compte des besoins perçus et vécus des HSH en République Centrafricaine." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/316093.
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Résumé français :Problématique :les hommes qui ont des rapports sexuels avec des hommes (HSH) constituent les populations les plus à risque d’infection au VIH dans différents pays d’Afrique subsaharienne. A ce jour, très peu d’interventions sont menées pour réduire le risque d’infection en influant sur les facteurs de risque, en Afrique Centrale et particulièrement en République Centrafricaine. Les objectifs de cette thèse visent à démontrer que les HSH sont identifiables et sont à risque des IST/VIH, que leur simple suivi médical ne permet pas un changement de comportements sexuels et réduire la fréquence des IST/VIH, mais que la combinaison d’interventions comportementale, biomédicale et structurelle permet, même en période de crise humanitaire, le changement de comportement sexuel et la réduction de la fréquence des IST/VIH. Méthodologie :Les HSH ont été enrôlés progressivement depuis 2010 pour atteindre un nombre de 220 en 2014. L’étude préliminaire sur les caractéristiques sociodémographiques et pratiques sexuelles à risque a concerné les 103 premiers HSH enrôlés en 2010. En 2012, la cohorte atteint le nombre de 170 HSH parmi lesquels 99 qui avaient un dossier médical complet ont fait l’objet de la deuxième étude du suivi sur deux ans.En 2013, alors que la cohorte des HSH avait atteint 200, 20 HSH ont été interviewés dans le cadre de l’étude qualitative. En 2014, la cohorte des HSH a atteint le nombre de 220. L’étude d’intervention a concerné 40 HSH sélectionnés sur les 220 et s’est poursuivie jusqu’en 2016.Résultats :L’analyse des caractéristiques socio démographiques des 103 HSH relève la présence de HSH jeunes. L’âge varie entre 15 et 40 ans, avec une médiane à 23 ans. Les pratiques sexuelles à risque sont fréquentes, notamment les premiers rapports sexuels avant 16 ans et sans préservatifs (70%) ;7% n’ont jamais utilisé les préservatifs, 56 % sont bisexuels, 98% pratique la pénétration anale. 31 HSH soit 24 %, étaient séropositifs pour le VIH ;22 soit 17% étaient infectés par le virus de l'hépatite B (VHB), dont 6 cas étaient coinfectés par le VIH et le VHB (M.B. Simaleko, et al.- Médecine d'Afrique Noire 6010 - Octobre 2013 - 409-414).En 2012, après deux ans de suivi médical et de counseling, il n’y a pas eu de changement de comportement et de pratiques sexuelles à risque, notamment en ce qui concerne la fréquence des rapports non protégés et la moyenne du nombre de partenaires occasionnels. La fréquence des principales IST a augmenté. Les prévalences du VIH, de la syphilis et de l’hépatite ont augmenté de manière significative et respectivement de 29% à 41%, de 12% à 21% de 14% à 23%. (Mbeko Simaleko M. et al. Pan Afr Med J. 2018; 29: 132).L’entretien avec les HSH a révélé plusieurs obstacles à l’utilisation des préservatifs, notamment, les ruptures, leur disponibilité, les fausses croyances, les pressions de l’entourage. (Mbeko Simaleko M. et al. Médecine et Santé Tropicale 2018 ;28 :424-429). De 2014 à 2016, l’étude d’interventions sur 40 HSH choisis de manière aléatoire et basée sur la combinaison des interventions comportementale, biomédicale et structurelle a permis d’améliorer le comportement et pratiques sexuelles des HSH par la réduction significative du nombre de partenaires sexuels occasionnels et l’augmentation significative de la fréquence des rapports sexuels protégés. À cet effet, il a été noté un seul cas de nouvelle infection par le VIH parmi les séronégatifs des 40 HSH contre 9 cas dans le groupe témoin. Aucune nouvelle infection au virus de l’hépatite B dans le groupe intervention contre 18, dans le groupe témoin. Il y a une augmentation significative de séropositifs dans le groupe témoin comparativement au groupe intervention en ce qui concerne la sérologie de la syphilis. (Mbeko Simaleko M. et al. Health Sci. Dis. 2020; 21: 94-99). Conclusion :les HSH sont identifiables et à risque. Le simple suivi médical associé au counseling ne permet pas d’améliorer le comportement sexuel et réduire la fréquence des IST. Cependant la combinaison des interventions a permis d’améliorer le comportement et la prise de risques des HSH mais également de réduire la fréquence des IST, même en période de crise humanitaire. Au vu du faible nombre de HSH inclus dans l’étude, il serait nécessaire d’étendre celle-ci, afin de conforter les résultats obtenus.Abstract Issue: Men who have sex with men (MSM) are the most at risk populations of HIV infection in different countries of sub-Saharan Africa. To date, very few interventions have been carried out to reduce the risk of infection by influencing on risk factors in Central Africa and particularly in the Central African Republic. The objectives of this research are to demonstrate that MSM are identifiable and at risk of STI/HIV, that the medical follow-up does not cause a change in sexual behavior and a reduction in the frequency of STI/HIV but that the combination of behavioral, biomedical and structural interventions allows, even in times of humanitarian crisis, behavioral change and reduction in the frequency of STI/HIV. Methodology: MSM have been progressively enrolled since 2010 to reach a number of 220 in 2014. The preliminary study on sociodemographic characteristics and sexual risk practices involved the first 103 MSM recruited until 2011. In 2012, 99 MSM who had a complete medical record were the subject of the second study on a two-year follow-up. In 2013, when the MSM cohort reached 200, 20 MSM were interviewed in the context of the qualitative study. In 2014, the MSM cohort reached 220. The intervention study involved 40 selected MSM out of the 220 and was continued during 2016.Results: MSM are predominantly young Their age varied between 15 and 40 years, with a median of23 years. Risky sexual practices were frequent, including first sexual intercourse before the age of 16 and without condoms (70%); 7% never used condoms, 56% are bisexual, 98% practice anal penetration. 31 MSM, or 24%, were HIV-positive; 22, or 17%, were infected with hepatitis B virus (HBV), of which 6 cases were co-infected with HIV and HBV (M.B. Simaleko, Set al. - Médecine d'Afrique Noire 6010 - Octobre 2013 - 409-414). In 2012, after two years of medical follow-up and counselling, there was no change in risk behavior and sexual practices, including the frequency of unprotected sex and the average number of occasional partners.The incidence of major STIs increased. The prevalence of HIV, syphilis and hepatitis increased significantly and respectively from 29% to 41%, from 12% to 21%, from 14% to 23%, respectively (Mbeko Simaleko M. et al. Pan Afr Med J. 2018; 29: 132). Interviews with MSM revealed several barriers to condom use, including condom breaks, condom availability, false beliefs, and peer pressure (Mbeko Simaleko M. et al. Médecine et Santé Tropicale 2018; 28: 424-429). From 2014 to 2016, the intervention study of 40 randomly selected MSM based on a combination of behavioral, biomedical, and structural interventions improved the sexual behavior and practices of MSM by significantly reducing the number of occasional sexual partners and significantly increasing the frequency of safer sex. Only 1 case of new HIV infection was noted among the 40 HSH HIV-negative compared to 9 cases in the control group. There were no new hepatitis B virus infections in the intervention group versus 18 in the control group. There was a significant increase in seropositivity in the control group compared to the intervention group with respect to syphilis serology (Mbeko Simaleko M. et al. Health Sci. Dis: Vol 21 (7) July 2020 pp 94-99). Conclusion: MSM were identifiable and most of them were at HIV risk. Simple medical follow-up combined with counselling does not allow to improve sexual behavior or to reduce the frequency of STIs. However, the combination of interventions has made it possible to improve the behavior and risk-taking of MSM and also to reduce the frequency of STIs, even in times of humanitarian crisis. In view of the low number of MSM included in the sample study and in order to consolidate the results obtained, it would be necessary to carry out a more in-depth study with a larger sample of MSM.Doctorat en Santé Publique
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Yamamoto, Kazuhiro, Shuta Sadaka, 和弘 山本, and 秀多 左高. "2速度RCAモデルによる避難過程のシミュレーション." 交通流数理研究会, 2010. http://hdl.handle.net/2237/19789.
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Homberg, Bettina [Verfasser]. "Regulation of Respiratory Chain Supercomplex Formation and the Involvement of Rcf-proteins / Bettina Homberg." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1235222667/34.
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Emelie, Wennerdahl. "Change in Thunderstorm Activity in a Projected Warmer Future Climate: a Study over Europe." Thesis, Uppsala universitet, Luft-, vatten och landskapslära, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-337148.
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In the last 100 years, a rise in the global mean temperature has been noted, and projections show even higher temperatures in the future. The temperature rise can lead to changes in the weather patterns and therefore the thunderstorm activity in a future warmer climate has been investigated in this study. The future projections were made with an ensemble of 8 General Circulation Models downscaled with the regional climate model RCA4, developed at SMHI. Temperature and humidity data at four different levels in the atmosphere has been used to compute three different stability indices. Stability indices indicate potential for deep convection in the atmosphere, from which thunderstorms are developed. It was found that the projections show an increase in thunderstorm potential in a warmer future climate. In Sweden, the projections show an increase with about 15 more days with risk of thunderstorms at the end of the 21st century for the RCP4.5 scenario, corresponding to an increase of 40% in the south, and an even larger increase in the north. For the RCP 8.5 scenario, the projected change in days with risk of thunderstorms corresponds to an increase about 20 days, or about 60% more thunderstorm days in south of Sweden. In other parts of Europe, the increase is expected to be even larger, mainly in the mountain regions. It was also found that the thunderstorm season is projected to be extended in the future, with more days with risk of thunder in May and September. The increase in number of days with risk of thunderstorms is a result of the greater amount of water vapour that the atmosphere is able to hold in a warmer climate. Even if thunderstorms are projected to increase, other factors counteract, such as a decrease in the vertical temperature gradient and a decrease in the difference between moisture in the upper and the middle atmosphere. Yet, taken together the days with risk of thunderstorms are projected to become more frequent.Under de senaste hundra åren har medeltemperaturen på jorden ökat med cirka 1°C, vilket har medfört förändringar i klimatet. Temperaturen kommer att fortsätta stiga på grund av den redan förhöjda halten växthusgaser i atmosfären, och om växthusgaser fortsätter släppas ut kan det förväntas bli ännu varmare. I och med att temperaturen fortsätter stiga är det mycket som pekar på att vädret i allmänhet kommer förändras, som till exempel förändrat mönster i åskoväder. I denna studie har risken för åska i ett framtida klimat studerats. Åska och konvektion bildas framförallt på grund av tre komponenter: instabilitet i atmosfären, fuktigheten i luften och en mekanism som får luften att lyftas från marken. En instabil luftmassa fås framförallt en varm sommardag när solen värmer marken, vilket medför att luften vid marken blir betydligt varmare än luften ovanför. Den andra faktorn är beroende av fuktigheten i luften, om luften är tillräckligt fuktig finns risk att större åskmoln kan bildas. De första två faktorerna kan beskrivas med vad som kallas stabilitetsindex. I denna studie beräknades risken för djup konvektion med hjälp utav stabilitetsindex. Temperatur-och fuktighetsdata från den regionala klimatmodellen RCA4, framställd på SMHI, användes för att beräkna dessa stabilitetsindex. Studien visar på att dagar med risk för åska förväntas öka i slutet av detta seklet med omkring 10-15 dagar per år över Sverige, med ännu fler dagar med risk för åska i södra Europa. En förhöjd åskrisk kan även förväntas vid bergskedjor så som svenska fjällen och Alperna. Den främsta anledningen till att åska förväntas bli vanligare är till följd av att temperaturstigningen möjliggör högre halt vattenånga i atmosfären, och därmed kommer fuktigheten i luften att öka. En längre åsksäsong har även noteras, med tidigare start i maj, och även förlängd i september.
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Sundström, Torbjörn. "Human brain function evaluated with rCBF-SPECT : memory and pain related changes and new diagnostic possibilities in Alzheimer’s disease." Doctoral thesis, Umeå universitet, Diagnostisk radiologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-761.
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The aim of this doctoral thesis was to study the influence of memory, pain, age and education on the regional cerebral blood flow (rCBF), i.e. brain function, in early Alzheimer's disease (AD) and in chronic neck pain patients in comparison to healthy controls and in healthy elderly per se. This was done by optimizing single photon emission computed tomography (SPECT) as a method to study rCBF with the tracer Technetium-99m (99mTc) hexamethylpropyleneamine oxime (HMPAO) and by matching all image data to a brain atlas before evaluation. The rCBF-SPECT was evaluated and developed to obtain higher diagnostic accuracy in AD and in chronic neck pain patients it was used to study basic pain related cerebral processes in chronic pain of different origin. A new semimanual registration method, based on fiducial marker, suitable for investigations with low spatial resolution was developed. The method was used to reconstruct images with an improved attenuation and scatter correction by using an attenuation-map calculated from the patients' previously acquired CT images. The influence of age and education on rCBF was evaluated with statistical parametric mapping, SPM in healthy elderly. The main findings were age related changes in rCBF in regions close to interlobar and interhemispheric space but not in regions typically affected in early AD, except for the medial temporal lobe. The theory of a 'cognitive reserve' in individuals with a longer education was supported with findings in the lateral temporal lobe, a region related to semantic memory, and in the frontal lobe. A cross-sectional study of chronic neck pain patients showed extensive rCBF changes in coping related regions in a non-traumatic pain patients compared to both healthy and a pain group with a traumatic origin, i.e. whiplash syndrome. The whiplash group displayed no significant differences in rCBF in comparison with the healthy controls. This suggests different pain mechanisms in these groups. The AD-patients showed a significantly lower rCBF in temporoparietal regions including left hippocampus. These changes were associated to episodic memory performance, and especially to face recognition. The diagnostic sensitivity for AD was high. The face recognition test (episodic memory) was used in AD patients to improve the sensitivity of method, i.e. memory-provoked rCBF-SPECT (MP-SPECT). The results were compared to healthy controls and the reductions of rCBF in temporoparietal regions were more pronounced in mild AD during provocation. Memory provocation increased the sensitivity of AD-related rCBF changes at group level. If a higher sensitivity for AD at the individual level is verified in future studies, a single MP-SPECT study might then be of help to set diagnosis earlier. In conclusion rCBF in temporoparietal regions are associated to an impaired episodic memory in early AD. Changes in these regions do not have a strong connection to chronological age. The diagnostic sensitivity of rCBF-SPECT in AD is high and there is a potentially higher sensitivity if memory provoked investigations are used. The findings in this thesis have given an increased knowledge of underlying cerebral pain processing in non-traumatic and traumatic (whiplash) neck pain. Preliminary results supporting the theory of 'cognitive reserve' by showing a correlation between long education and preserved rCBF was found in healthy elderly.
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Mulero, Roig María Carmen. "Estudi de la funció de les proteïnes RCAN en l'activació limfocitària: Aplicació en la cerca de nous fàrmacs immunosupressors." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/1823.
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Calcineurina (Cn), l'única serina treonina fosfatasa dependent de Ca2+ i calmodulina identificada fins al moment, és un enzim clau en la regulació de diverses vies de senyalització cel·lular, entre elles, l'activació limfocitària. Actualment, els protocols d'immunosupressió inclouen l'ús de fàrmacs anticalcineurínics, CsA i FK506, però la seva administració continuada comporta l'aparició de greus efectes secundaris. En els darrers anys s'han descrit diversos inhibidors endògens de Cn, entre ells la família de les calcipressines o regulators of calcineurin (RCAN), que en humans consta de tres membres RCAN1, RCAN2 i RCAN3. Fins al moment de realitzar aquest treball s'havia descrit que RCAN1 interacciona i inhibeix l'activitat fosfatasa de Cn respecte la família de factors de transcripció NFAT a diversos teixits, però no s'havia estudiat a limfòcits T humans. Per això, es va analitzar la interacció de les proteïnes RCAN1 i RCAN3 amb Cn a limfòcits T, així com avaluar el potencial immunosupressor de dites interaccions respecte a la via de senyalització Cn-NFAT.Els resultats obtinguts han mostrat que els transcrits RCAN1-1 i RCAN3-1,2,3,4,5 s'expressen a nivell basal en línies cel·lulars de limfòcits T humans, Jurkat i Hut78, mentre que el transcrit RCAN1-4, no. A més, l'expressió gènica de RCAN1-4 depén d'un senyal de Ca2+-Cn, mentre que l'expressió dels altres dos transcrits analitzats, no. Mitjançant experiments de co-immunoprecipitació s'ha demostrat que en cèl·lules Jurkat, la interacció RCAN1-1-Cn te lloc de manera endògena i mitjançant assaigs de pull down s'han identificat els dos motius de RCAN1-1 implicats, el motiu CIC i el motiu PxIxxT. En el cas de RCAN3-2, s'ha descrit per primer cop que aquesta proteïna sobreexpressada interacciona amb Cn i que ho fa únicament a través del seu corresponent motiu CIC. Assaigs funcionals in vivo han mostrat que únicament el motiu CIC de les RCAN és el responsable directe de la inhibició de la via de senyalització Cn-NFAT. Com a conseqüència, en cèl·lules Jurkat, s'ha demostrat el potencial immunosupressor del motiu CIC de les RCAN respecte l'expressió gènica de diverses citoquines dependents de NFAT. L'acotament del motiu CIC de les RCAN ha permès identificar una seqüència de 21 aminoàcids, a la qual s'ha anomenat C18, i que correspon a la regió mínima de les RCAN capaç d'inhibir la via de senyalització Cn-NFAT.
Les interaccions C18-RCAN1-Cn i C18-RCAN3-Cn han estat posades a punt i caracteritzades in vitro mitjançant anisotropia de fluorescència. A més, s'ha demostrat que les proteïnes RCAN i NFAT s'interfereixen en la seva interacció amb Cn i que probablement les interaccions C18-RCAN1-Cn i C18-RCAN3-Cn no impliquen la participació directa del centre actiu de Cn. En conjunt, aquests resultats suggereixen que l'efecte immunosupressor de les RCAN seria més específic que el que promouen els fàrmacs inhibidors de Cn, CsA i FK506, utilitzats actualment. Amb la finalitat d'identificar noves molècules amb potencial immunosupressor es van realitzar diversos cribratges utilitzant quimioteques combinatòries que disruptin la interacció C18-RCAN1-Cn. A partir d'aquests experiments s'han identificat quatre hexapèptids i un producte denominat IDI3A que desplacen de manera dosi-dependent la interacció analitzada. L'avaluació funcional del producte IDI3A ha demostrat que aquest inhibeix in vivo la via de senyalització Cn-NFAT i que per tant, te cert efecte immunosupressor. Aquestes dades indiquen que, tant els pèptids C18 de les RCAN com l'assaig in vitro que s'ha dissenyat, constitueixen dues noves eines útils en la cerca de molècules amb potencial immunosupressor.
Calcineurin (Cn), a calcium and calmodulin dependent serine-threonine protein phosphatase, is a key enzyme involved in many cellular processes, including T cell activation. Activated Cn dephosphorylates many substrates, among them the nuclear factor of activated T cells (NFAT) transcription factors, inducing their translocation to the nucleus. There, NFAT are key components of the cytokine gene expression stimulation that triggers T cell activation. Current immunosuppressive protocols include the administration of CsA and FK506, but their continuous use has been correlated with severe side effects. Recently, several Cn endogenous inhibitors have been described, including the protein family of Cn regulators (RCAN, previously known as calcipressins or DSCR1). In the present study it has been characterized the RCAN1 and RCAN3 interaction with Cn in human T lymphocytes. Moreover, it has been evaluated the functional consequence of these interactions towards the Cn-NFAT signalling pathway in vivo.
It has been shown that RCAN1-1 interacts endogenously with Cn in T cells and such interaction takes place through two independent RCAN1-1 sequences, the CIC and the PxIxxT motifs. Moreover, it has been described for the first time that RCAN3-2 binds to Cn and this interaction occurs only through the RCAN3-2 CIC motif. In vivo functional assays have shown that the RCAN CIC motif is the unique direct responsible for the inhibition of the Cn-NFAT signalling pathway. In human T cells, the RCAN CIC motif inhibits NFAT-dependent cytokine gene expression confirming its immunosuppressive effect.
Moreover, it has been identified the minimal RCAN-derived sequence spanning 21 amino acids, which is part of the RCAN CIC motif, that retains the ability of inhibiting the Cn-NFAT signaling in vivo. Peptides spanning this sequence from RCAN1 and RCAN3, have allowed to study the binding mechanism of RCAN proteins to Cn. In vitro, these RCAN-derived peptides bind to Cn with high affinity and selectively inhibit the interaction of Cn with NFAT. Indeed, by screening chemical and peptide libraries, four hexapeptides and a product called IDI3A that modulates the RCAN-Cn interaction in vitro have been identified. In addition, it has also been demonstrated that the IDI3A product inhibits the Cn-NFAT signaling pathway in vivo.
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Menon, Rajiv G. "Regional cerebral blood flow (RCBF) calculations in awake, behaving non-human primates using continuous arterial spin labeling (CASL) techniques." Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/menon.pdf.
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JIA, LIN. "Adaptation de la cyanobacterie calothrix pcc 7601 a son environnement, caracterisation de deux elements de regulation : rcaa et cyaa." Paris 7, 1996. http://www.theses.fr/1996PA077224.
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Les cyanobacteries sont des procaryotes qui effectuent les reactions de la photosynthese en degageant de l'oxygene. Parmi elles, la souche filamenteuse calothrix pcc 7601 possede des proprietes physiologiques remarquables: elle est photoheterotrophe facultative, elle possede de plus les genes nif et peut differencier des proheterocystes ; elle peut aussi differencier des hormogonies, petites cellules mobiles remplies de vesicules a gaz conferant aux cellules une flottabilite ; enfin, elle peut moduler la nature des pigments de ses antennes photocollectrices (phycobilisomes) selon la qualite spectrale de la lumiere (adaptation chromatique complementaire). En lumiere rouge, les cellules contiennent de la phycocyanine-2 (operon cpc2), tandis qu'en lumiere verte elles contiennent de la phycoerythrine (operons cpe). Cette adaptation resulte d'un controle transcriptionnel des operons correspondants, rcaa et rcab en lumiere verte pour cpeba, rcad en lumiere rouge pour cpc2 etant des proteines affines specifiques. Une methode de purification a ete developpee qui a permis d'obtenir une preparation tres homogene de la proteine rcaa. Par des experiences de transcription in vitro controlee, nous avons montre que rcaa modifiait l'efficacite et la specificite de transcription pour au moins quatre promoteurs d'operons codant pour des phycobiliproteines, et que les proprietes de rcaa en tant que facteur de transcription etaient affectees par son etat de phosphorylation. A partir de la sequence de peptides internes a rcaa, et par des experiences d'amplification de type pcr, le gene rcaa a ete clone. Apres sequencage, il est apparu que rcaa presente beaucoup d'homologie avec les glutamyl tarn synthetases (gltx), observation dont les consequences sont discutees. Un modele est propose pour la regulation transcriptionnelle de l'expression des operons codant pour les composants majeurs des phycobilisomes, lors de l'adaptation chromatique complementaire chez calothrix pcc 7601. Enfin, le gene cyaa de calothrix pcc 7601 a ete caracterise. Il code pour une adenylate cyclase (686 residus) de classe iii (universelle) de structure tres originale, la partie n-terminale (aa 1-260) et la partie centrale (aa 321-450) formant deux domaines, respectivement tres similaires aux histidine kinases (sensors) et aux transmetteurs (response regulators) des systemes a deux composants tres repandus dans le monde bacterien
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Kim, Sukwon. "Relationships between Hamstring Activation Rate and Biomechanics of Slip-induced Falls among Young and Older Adults." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/43308.
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This study was conducted to investigate whether hamstring muscle activation rate could potentially serve as an indicator for slip-induced falls, particularly for older adults. Kinematics (heel contact velocity, walking velocity, slip distance, and step length), kinetics (friction demand), and electromyography (EMG) while walking over a slippery surface were collected and examined in the study. Normalized EMG data were examined in term of activation rate and compared to heel contact velocity. Twenty-eight subjects from two age groups (14 young and 14 elderly) walked across a track with embedded force platforms while wearing a fall arresting harness attached to an arresting rig for safety. In order to obtain realistic unexpected slip-induced fall data, the slippery surface was hidden from the subjects and unexpectedly introduced. The primary objective of the study was to evaluate if hamstring activation rate could be a valid indicator for the initiation of slip-induced falls. The results suggested that hamstring activation rate in younger adults was higher than older adults, whereas, younger adults’ heel contact velocity was not different from older adults. These results suggested that heel contact velocity in younger adults was sufficiently reduced before the heel contact phase of the gait cycle. This could be due to the outcome of higher hamstring activation rate in younger adults in comparison to older adults. However, an equal number of falls in two age groups, in spite of older adults’ slower walking velocity, lower RCOF, shorter slip distance, and slower peak sliding heel velocity, suggested that the recovery phase of the slip-induced fall accidents should be studied further.Master of Science
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Capps, Steven G. "A Radical Conjugate Addition Approach to the Total Synthesis of Celogentin C." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1831.
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The synthesis of five chiral DBFOX (dibenzofuran-oxazoline) ligands with either aryl or benzyl substituents will be presented. The requisite amino alcohols were obtained with high enantioselectivity either commercially (DBFOX/Bn), via Sharpless asymmetric aminohydroxylation (DBFOX/Nap, DBFOX/t-BuPh, DBFOX/Pip), or via phase-transfer catalyzed asymmetric alkylation (DBFOX/MeNap). These ligands, complexed with Mg(NTf2)2, were used as Lewis acid promoters of enantioselective radical conjugate additions to α/β-unsaturated nitro-amides/esters. A summary of these results is presented and discussed. These findings led us to believe that our initial binding model between metal, ligand, and substrate was flawed. Thus, we figured that if we started with a functionality known to bind to both nitro groups and carbonyls, and then introduced a chiral element for control, we may be able to improve the beta-carbon enantioselectivity. We have tried to accomplish this via hydrogen-bonding ligands (ureas and thioureas). Initial studies on achiral versions of this concept are discussed.
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Ohlsson, Alexandra. "The accuracy of the wind stress over ocean of the Rossby Centre Atmospheric model (RCA)." Thesis, Uppsala universitet, Luft-, vatten och landskapslära, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303873.
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The aim of this study is to investigate how well the wind stress is described in the regional climate model RCA (Rossby Centre Atmospheric model). The model data is compared with measurements taken at Östergarnsholm, an island located east of Gotland in the Baltic Sea. The investigation covers the period October 1997 to September 2000. Compared with the measurements RCA underestimates the wind speed over ocean in most cases. When the wind speed is studied in monthly mean it was found that the wind speed is consistently underestimated in the model, especially during summer and early winter. The wind stress is also underestimated during the year except during late winter and in October when it is overestimated. When wind speed from the model and measurements were studied it was found that lower wind speed is overestimated in the model. This contributes to overestimation of the wind stress for lower wind speeds. For higher wind speeds both wind speed and wind stress is underestimated in RCA. If the model would have a correct wind speed the wind stress would be overestimated with 20-30 % for all wind speeds compared to the measured. This is probably due to miscalculations of wind stress in the model. RCA fail to capture the stability in a satisfactory way. The model describes most of the times a different stratification than the measurements do. Separate studies over modeled and measured wind speed and wind stress was made. RCA is found to represent stable condition well. During unstable stratification modeled wind speed and wind stress are underestimated. Investigation of the measured wave age shows that the model underestimates both wind speed and wind stress for growing sea and mature sea. For the situations when the measured wave age was defined as swell the model overestimated wind speed and wind stress.2Den här studien tar upp hur väl friktionen över havsytan beskrivs i den regionala klimatmodellen RCA (Rossby Centre Atmospheric model). Modelldata jämförs med mätningar gjorda på Östergarnsholm, en ö belägen öster om Gotland i Östersjön. Studien spänner över tidsperioden oktober 1997 till september 2000. RCA underskattar i många fall vindhastigheten på 10 m över havsytan jämfört med mätningarna. Då månadsmedelvärden studeras visar det sig att modellen genomgående underskattar vindhastigheten, särskilt på sommaren och på vintern. Friktionen överskattas under sen vinter och för oktober månad. För alla andra månader underskattas friktionen. Studier över vindhastigheterna visar på att de lägre vindhastigheterna överskattas i modellen. Detta bidrar till överskattning av friktionen för de lägre vindhastigheterna. För högre vindhastigheter underskattar RCA vindhastigheterna och därmed även friktionen. Om modellen skulle ge en korrekt vindhastighet skulle resultatet istället visa på en överskattning av friktionen med 20-30 % för alla vindhastigheter. Detta beror troligen på felaktigheter i beräkningen av friktionen i modellen. Stabiliteten visar sig vara dåligt beskriven i RCA. I de flesta fall är skiktningen i modellen och mätningarna helt olika. Jämförelser mellan separata studier mellan modelldata och mätningar visar att vindhastigheten och friktionen beskrivs bra under stabila förhållanden, men i samband med instabil skiktning underskattas vindhastigheten och friktionen i modellen. Studier över den uppmätta vågåldern visar att modellen underskattar både vindhastigheten och friktionen för växande och fullvuxen sjö. Då det råder dyning överskattar modellen både vindhastigheten och friktionen.
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Wang, Yali S. M. Massachusetts Institute of Technology. "A simplified constant-liquidity price index for U.S. commercial property based on the RCA database." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46380.
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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Architecture, 2008.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Includes bibliographical references (leaf 86).
This thesis builds on the endogenous relationship between transaction price and volume in commercial real estate markets in order to construct a simple "constant-liquidity price index" (SCLI) applicable to general transaction databases such as that of Real Capital Analytics Inc (a MIT/CRE member firm). By recognizing the fact that current commercial property indices do not capture the demand-side of the market (potential property buyers), which is the source of liquidity in the market, the type of index developed in this thesis fills a gap in the need for commercial property investment information. The ease of selling a property at the price indicated by an index of average realized prices (in closed deals) is variable and highly correlated with market cycles. And investors care not only for the price but also want to know how easy it is to sell property at those prices. This thesis is an extension of the formal study of constant-liquidity indexing (Transaction based supply and demand index) developed by Fisher, Gatzlaff, Geltner and Haurin (2003) based on the NCREIF (National Council of Real Estate Investment Fiduciaries) Property Index (NPI) transaction data base (hereafter referred to as "FGGH"). Compared with the underlying more rigorous econometric model of FGGH, this thesis presents a simplified approach to construct a constant liquidity price index (hereafter referred to as "Simplified Constant-Liquidity Price Index/ SCLI") suitable for a more typical type of commercial property transaction database, one that contains data only on sold properties (the NCREIF database used by FGGH contains data on both sold and unsold properties).
(cont.) In this thesis, monthly SCLIs are compared with the corresponding realized price indices and the results suggest that the SCLIs tend to lead the price indices and display a greater volatility. The SCLI developed here behaves similarly to the more econometrically rigorous FGGH-based demand-side indexes, therefore tends to validate the construction method of the SCLI, suggesting that this could be a useful information product and possibly a valuable tool for investment allocation and derivatives trading.
by Yali Wang.
S.M.
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Akentuna, Moses. "CHARACTERIZATION OF RECYCLED CONCRETE AGGREGATES (RCA) FROM AN OLD FOUNDATION STRUCTURE FOR ROAD PAVEMENT WORKS." OpenSIUC, 2013. https://opensiuc.lib.siu.edu/theses/1207.
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The use of recycled concrete aggregates in Portland cement concrete and granular road base or sub-base works has increased steadily all over the world in order to conserve the limited natural aggregate deposits. The recycling of the demolished concrete aggregate for the use in concrete or granular pavement works will not only help to protect the environment but also an economical benefit to the user. The main drawback for the bulk utilization of demolished or recycled aggregate is its characterization and proper quality control during its production. The overall objective of this research was to characterize recycled concrete aggregates (RCA) obtained from a demolished foundation structure and to determine its suitability for Portland Cement Concrete (PCC) works and use as a granular road base or sub-base material. Tests were carried out on RCA samples to determine whether it meets the specification for concrete aggregate material or a granular road base and sub-base materials. Several concrete mixes consisting of 10, 20, 30, 40, 60, and 80 % replacement of natural coarse aggregates (NCA) with RCA were prepared and tested for compressive strength after curing periods of 7, 14, and 28 days. The compressive strength of concrete made with various percentages of RCA decreased with increasing RCA content but it increased with curing period for all concrete mixes. The durability parameters of the natural aggregates and RCA samples were investigated by using sulfate soundness, rapid freeze-thaw and micro-deval tests to ascertain their chemical and abrasive resistance. The California Bearing Ratio (CBR) of RCA base was also compared with that of a natural road base material to determine its suitability for road base or sub-base works. In this study, the flakiness and elongation indices of the RCA were found to be better than that of conventional natural aggregates. The RCA base material had lower maximum dry density, higher optimum moisture content, and low California Bearing Ratio (CBR) value compared to the natural crushed rock base (NCRB) material but was found to be a relatively good road base material.
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Pascal, Lionel. "La privatisation des missions douanières en République Centrafricaine (RCA) : une opportunité d'amélioration des finances publiques ?" Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0118/document.
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Pour assurer ses missions les États ont besoin de prélever l’impôt afin de s’assurer des ressources. Lacaractéristique des États en développement est, en matière de Finances Publiques, d’avoir des recettesbasées essentiellement sur les taxes prélevées en frontière sur les marchandises. Malheureusement dansces pays là, l’efficacité des Organisations Douanières est rarement au rendez-vous, notamment du faitd’une corruption très importante parmi les douaniers.Aussi les Organisations Internationales recommandent une privatisation partielle des missions afind’améliorer les recettes. Les sociétés privées se sont spécialisées dans cette forme de recouvrement etainsi la plupart des pays africains ont recours à l’une ou l’autre des sociétés dites de " pré-inspection ".Après des années de pratique peut-on évaluer l’efficience de cette privatisation ? L’exemple de la RCAest particulièrement pertinent pour étudier cela puisque d’une part ce pays a poussé la privatisation àl’ensemble des missions douanières, ce qui est unique au monde et d’autre part la situation actuelle de cepetit pays découle au moins en partie de l’absence d’une administration des douanes solide.Dans l’écroulement des structures administratives de ce pays, assisté depuis sa création par toutesles Organisations Internationales, ces dernières, sont-elles exemptes de reproches ?STATES collect revenue from taxes to provide necessary financial resources to the accomplishmentof their missions. Developing states have a common characteristic namely to collect revenue mainly onimported goods. Unfortunately customs administrations of these countries are generally inefficient due toa very high level of corruption of their personnel.Faced to this situation, internationals organisations advised to outsource some of the customs func-tions in order to improve the collection of revenue. Private companies developed new activities in thisarea and today most African countries have contracted out one or several of these companies usuallycalled preshipment inspection companies. After several years is it feasable to assess the efficiency of thatoutsourcing ? CAR is an excellent and pertinent study case to perform this assessment. On one hand,this country has outsourced all of the customs fonctions, which is a unique exemple in the world. Onthe other hand, there is a strong link between the existing situation of this country and the lack of anefficient customs administration.Can we blame these international organisations, which have assisted CAR since it’s creation, for thecollapse of the administrative structures of this country ?
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Lidström, Jonatan. "Rotorsaksanalyser av testriggar : En studie av vad som krävs av Scanias forsknings- och utvecklingsavdelning för att rotorsaksanalyser ska fungera på bästa sätt." Thesis, Linköpings universitet, Interaktiva och kognitiva system, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119829.
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När Scanias maskiner som ska testa nya lastbilskomponenter eller hela lastbilar, så kallade testriggar, inte fungerar som de ska så fanns det i dagsläget en uppfattning att problemen i vissa fall dels var återkommande och dels var svåranalyserade. På grund av detta ville Scania Tekniskt Centrum (STC) införa rotorsaksanalyser av när testriggar inte fungerade som de skulle. Denna studie har undersökt vad som i dagsläget behövde förändras och vad som möjliggjorde att rotorsaksanalyser av fallerande hos testriggarna skulle fungera så bra som möjligt. En nulägesanalys gjordes. Resultaten av denna visade på att fyra roller fanns som var involverade i att åtgärda fel hos testriggarna, nämligen de som äger riggarna, de som arbetar med underhåll av riggarna, de som utvecklar riggarna och de som är ansvariga för arbetsmiljön och säkerheten hos riggarna. En process map skapades för att visa hur dessa roller i dagsläget samverkade för att bygga testriggar och åtgärda fel hos dem. Resultaten av nulägesanalysen visade på att fyra övergripande faktorer påverkade huruvida rotorsaksanalyser skulle kunna genomföras. Den första var att ha ett väldefinierat standardförfarande att följa. Den andra var att det fanns en kultur som tillät att utföra rotorsaksanalyser. Den tredje var att bakgrundskunskap kring ett fel skulle finnas tillgänglig. Den fjärde var att kunna sammansätta grupper av olika typer av roller som skulle kunna samarbeta. Dessa fyra faktorer var de som utgicks ifrån för att redovisa saker som fungerade väl och saker som krävde förändring för att rotorsaksanalyser skulle fungera på bästa sätt. Utöver detta gavs förslag på förändringar som skulle åtgärda saker som förhindrade rotorsaksanalyser.
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Popelka, Jakub. "Vliv cílené modifikace topografie na únavové poškozování třecích povrchů." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-227904.
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Diploma thesis describes influence of directed modificated topography of frictional surfaces on fatigue wear non-conformal incurvate solids. It was created 3D parametric model of experimental test rig in modelling environment Autodesk Inventor. With the help of model was designed and carried reconstruction of experimental test rig so to possible obtain repeatable results under the sliding conditions of frictional surfaces. It enabled show influence of surface iregularities (dents) frictional surfaces on contact fatigue service life in conditions mixed lubrication regime and different values of slide to roll ratio.
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Sundström, Torbjörn. "Human brain function evaluated with rCBF-SPECT : memory and pain related changes and new diagnostic possibilities in Alzheimer?s disease /." Umeå : Strålningsvetenskaper Radiation Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-761.
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Finelli, Fernanda Gadini. "Sintese da macrolactona da migrastatina e analogo : sinteses e aplicações de novos substratos em reações de RCAM catalisadas por [Mo]." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248483.
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Orientador: Luiz Carlos DiasTese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica
Made available in DSpace on 2018-08-13T21:30:59Z (GMT). No. of bitstreams: 1 Finelli_FernandaGadini_D.pdf: 6560101 bytes, checksum: 5eb9e7f25248bb940dd29d8af3e505ed (MD5) Previous issue date: 2009
Resumo: O capítulo 1 relata as sínteses da macrolactona da migrastatina 11 e da macrolactona análoga 62a. A macrolactona da migrastatina é o composto que apresenta a maior atividade de inibição de migração de células tumorais in vitro dentre os compostos da família da migrastatina até hoje sintetizados. A macrolactona 62a, ainda inédita na literatura, é epímero em C8 da macrolactona 62b sintetizada pelo grupo do Professor Danishefsky em 2004 e apresenta atividade de inibição semelhante à macrolactona 11. Além disso, foram realizados estudos visando à síntese da macrolactona 124, epímero da macrolactona 11. Paralelamente, em colaboração com a Farmoquímica Cristália e o grupo do Professor Adriano Andricopulo, do IF/USP de São Carlos, foram realizados testes de avaliação biológica de diversos compostos sintetizados neste trabalho com o intuito de gerar novas substâncias químicas bioativas candidatas a novos fármacos no tratamento do câncer de mama. O capítulo 2 relata a síntese e aplicação de alguns substratos contendo grupos funcionais que ainda não haviam sido testados frente à reação de metátese de alcinos utilizando um novo catalisador de molibdênio. Este projeto foi desenvolvido no laboratório do Professor Alois Fürstner, no Instituto Max-Planck, em Mülheim an der Ruhr ¿ Alemanha. Além disso, um precursor do fragmento B das Latrunculinas A e B foi sintetizado em grande escala, fornecendo material para subsequentes estudos químicos e biológicos
Abstract: Chapter 1 describes the syntheses of macrolactones 11 and 62a. Macrolactone 11 presents the best tumor cell migration inhibitory effect among the compounds of the migrastatin family synthesized so far. Macrolactone 62a, not described in the literature, is the C8-epimer of macrolactone 62b, which was synthesized by Professor Danishefsky¿s group in 2004 and shows similar antitumor activities when compared to macrolactone 11. Studies aiming at the synthesis of macrolactone 124, epimer of macrolactone 11, were also performed. Besides, in collaboration with Farmoquímica Cristália and Professor Andricopulo¿s group (IF/USP, São Carlos), biological assays of several compounds synthesized in this work were carried out, with the purpose of developing new bioactive chemical substances which may soon be employed in the manufacturing of novel drugs in the treatment of breast cancer.Chapter 2 describes the syntheses of new substrates for applications in Mo-catalyzed RCAM. This project was carried out in Professor Fürstner¿s laboratory, at Max-Planck Institute, in Mülheim an der Ruhr ¿ Germany. In this part of the work, a Latrunculin A and B fragment precursor was also synthesized in large scale to provide further material for new biological and chemical studies
Doutorado
Quimica Organica
Doutor em Ciências