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Journal articles on the topic 'RCC T-beam and Pre-stressed'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Navneet, Chaudhary, K. Mishra A., and S. Aithal P. "Analysis of Price Adjustment Payments for RCC T-Beam and Pre-stressed Bridges Construction Contracts." International Journal of Case Studies in Business, IT, and Education (IJCSBE) 7, no. 1 (2023): 141–63. https://doi.org/10.5281/zenodo.7646075.

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<strong>Purpose: </strong><em>Let’s compare and analyze the price adjustment payments for RCC T-beam and Pre-stressed bridges construction contracts for evaluation of the cost effectiveness of price adjustment payment.</em> <strong>Design/Methodology/Approach: </strong><em>Based on Questionnaire survey and Official documents, </em>comparison<em> and analysis were done for RCC T-beam and Pre-stressed bridges construction contracts of price adjustment payment.</em> <strong>Findings/Result: </strong><em>The </em><em>weightage of price adjustment payment is 9% of total payment. This assessme

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2

A., K. Mishra, Chaudhary Navneet, and S. Aithal P. "Evaluation of Price Adjustment Coefficient for Construction Contracts." International Journal of Management, Technology, and Social Sciences (IJMTS) 8, no. 1 (2023): 119–39. https://doi.org/10.5281/zenodo.7646098.

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<strong>Purpose: </strong><em>There are many bridges being constructed in Nepal. Brides of different types like Bailey truss, cable stayed, RCC Arch, pre-stressed, RCC Slab, RCC T-Beam, Steel truss, RCC Box, Stone masonry arch, suspension, and suspended bridges are being tendered and constructed at present in Nepal. Most of the bridges being constructed are of RCC T-beam and Prestressed bridges. It has been found the need to carry out research to develop logical price adjustment coefficient ranges for RCC T-beam and Prestressed bridges contracts to make the price adjustment provision more unif

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3

Gurunaathan, K., S. Christian Johnson, and G. S. Thirugnanam. "Anticipated and actual performance of composite girder with pre-stressed concrete beam and RCC top flange." Structural Engineering and Mechanics 61, no. 1 (2017): 117–24. http://dx.doi.org/10.12989/sem.2017.61.1.117.

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4

Shakir, Qassim M. "NONLINEAR ANALYSIS OF R.C. BEAMS STRENGTHENED USING PRE-STRESSED NSM CFRP RODS." Kufa Journal of Engineering 5, no. 2 (2014): 13–28. http://dx.doi.org/10.30572/2018/kje/521321.

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A nonlinear finite element study has been conducted to investigate the effectiveness of strengthening RC beams with pre-stressedNSM CFRP rods in enhancing the flexural strength ofthe beams. Four beams have been considered. One acted as control to simulate an existing structural member. The other beams were strengthened with non-pre-stressed CFRP rod (0% pre-stressed), and pre-stressed CFRP rod (40%, or 60% pre-stressed of the CFRP rod tensile strength). The results of analysis showed that strengthening of the RC beams with non pre-stressed NSM CFRP rods improved both of the flexural capacity a

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5

Ahmed, Zeeshan Adib. "Comparative Study of Deflection Behavior of RCC and Pre-stressed Concrete Beams." International Journal for Research in Applied Science and Engineering Technology 7, no. 5 (2019): 973–79. http://dx.doi.org/10.22214/ijraset.2019.5163.

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6

Shanmughan, Suchithra, Sampathkumar Velusamy, Jothi Lakshmi Nallasamy, et al. "Critical Study on Corrosion Inhibitors in U-Shaped RCC Beams." Advances in Materials Science and Engineering 2022 (May 29, 2022): 1–8. http://dx.doi.org/10.1155/2022/4762524.

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In most structural failures, deterioration of reinforced concrete structure is due to corrosion of reinforcing bars. Ingress of chloride ions and reaction of carbon dioxide with the cement paste due to poor-quality concrete or inadequate cover are the main causes of corrosion. Corrosion can be reduced by using high-quality concrete and providing proper cover to reinforcement. In addition, corrosion inhibitors are used to protect the reinforcement in order to extend the service life of concrete structures. This research work is focused on determining the effectiveness of corrosion inhibitors un

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Prakash, Arya. "Analysis of Multi-Storied Building with Prestressed Beam using ETABS." International Journal for Research in Applied Science and Engineering Technology 9, no. VI (2021): 5188–94. http://dx.doi.org/10.22214/ijraset.2021.36137.

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Concrete is good in compression and weak in tension and the steel is strong in tension. So the use of reinforced concrete to resist compression and to hold bars in position and to the steel resist tension. In India RCC structures are commonly used in residential as well as business buildings. Nowadays the Post Tensioning method is widely used due to its advantages. Post tensioning is a form of prestressing, that means the steel is stressed before the concrete has to support the service loads. In this paper is exposed to the assessment of execution of Reinforced concrete beam (RCC beam) and Pos

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Negi, Ankit. "A Study on Energy Dissipation in Rcc Beam Column Joints Using Semi Rigid Connection." Mathematical Statistician and Engineering Applications 70, no. 2 (2021): 1223–36. http://dx.doi.org/10.17762/msea.v70i2.2190.

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Beam column joint failure has been linked to the partial or whole collapse of reinforced structures, according to information gathered during seismic reconnaissance. Under seismic stress, the failure of a single beam has only a limited impact, but the failure of a beam-column junction might lead to the collapse of the whole structure. The resulting economic damage and human casualties are substantial. Hence, keeping the beam and column from coming apart is crucial. Recent earthquakes have caused significant damage to important structures, and this is mostly attributable to a lack of ductility

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Hamah-Ali, Brwa Hamah Saeed, and Mohamed Raouf Abdul Qadir. "The effect of different levels of pre-damage loading on the strength and structural behavior of CFRP strengthened R.C. beams: Experimental and analytical investigation." PLOS ONE 16, no. 12 (2021): e0261290. http://dx.doi.org/10.1371/journal.pone.0261290.

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In order to investigate the effect of pre-loading damage on the structural performance of Carbon Fiber Reinforced Polymer (CFRP) strengthened Reinforced Concrete (R.C.) beams, experimental and Finite Element Modelling (FEM) investigation was carried out on six R.C. beams. Five of the R.C. beams were damaged up to different levels of strain in the main steel bars before Flexure CFRP strengthening. One of the R.C. beams loaded up to failure and was kept as a control beam for comparison. The experimental results showed that the failure mode of the CFRP strengthened specimen was controlled by CFRP

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10

Chen, Xiao Ying, Jing Zhuo, and Tang Ning Li. "Experimental Research and Principle on Strengthened T-Beam with External Pre-Stressed Variable Section CFRP Sheets Based on Moment." Advanced Materials Research 1030-1032 (September 2014): 774–80. http://dx.doi.org/10.4028/www.scientific.net/amr.1030-1032.774.

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An innovative external pre-stressed strengthening method, in which FRP (fiber reinforced polymer) sheet is placed outside of the concrete section and anchored in multiple-point, is based on moment of beam to change the area of section of FRP sheet along the length of beam. This strengthening method is that two ends of FRP sheet are first anchored by tightening WSGA (Wave-shaped-gear-anchor), then the FRP sheet is tensioned by tightening WSGG (Wave-shaped-gear-grip) on the middle of FRP sheet and accordingly pre-stressing force is built in FRP sheet. Two same 7m long reinforced concrete T-beams

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11

Sun, Jin Kun, Shuang Hua Huang, and Yue Shui Lin. "Design and Application of 40m T- Beam Installation with Steel Trestle Bridge Made by Type- 64 Military Railway Girder." Advanced Materials Research 304 (July 2011): 101–6. http://dx.doi.org/10.4028/www.scientific.net/amr.304.101.

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In the case of installation of 40m pre-stressed reinforced concrete T-beam of Bridge A in a high energy-consuming industrial park, difficulties such as poor geology within bridge spans, too heavy T-beam and lack of conditions for installation of steel trestle bridge have been overcome. Finally, the problem of 40m T-beam installation has been resolved through reasonable design and by using type-64 military railway girder to make steel trestle bridge [1].Meanwhile, due to the restriction of terrain, T-beam is pre-cast on the base of lead road with 100m of corner radius, 97 meters away from the b

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Khalil, Ahmed, Mohamed Elkafrawy, Rami Hawileh, Mohammad AlHamaydeh, and Wael Abuzaid. "Numerical Investigation of Flexural Behavior of Reinforced Concrete (RC) T-Beams Strengthened with Pre-Stressed Iron-Based (FeMnSiCrNi) Shape Memory Alloy Bars." Journal of Composites Science 7, no. 6 (2023): 258. http://dx.doi.org/10.3390/jcs7060258.

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Shape memory alloy (SMA) is a material that can change shape in response to external stimuli such as temperature, stress, or magnetic fields. SMA types include nitinol (nickel-titanium), copper-aluminum-nickel, copper-zinc-aluminum, iron-manganese-silicon, and various nickel-titanium-X alloys, each exhibiting unique shape memory properties for different applications. Reinforced concrete (RC) T-beams strengthened and pre-stressed with Fe-SMA bars are numerically investigated for their flexural response under the influence of various parameters. The bars are embedded in a concrete layer attached

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Geraldo, De-Lima Eri, Banahene Osei Jack, and Adom-Asamoah Mark. "Behaviour of Bamboo Reinforced Concrete Beams With 100% Recycled Coarse Aggregate." Journal of Ceramics and Concrete Sciences 4, no. 1 (2019): 4–13. https://doi.org/10.5281/zenodo.2543482.

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<em>The behavior of bamboo reinforced concrete (BRC) beams with 100% recycled aggregates (RA) was studied to ascertain the viability of the substitute materials and its adherence to predictions. Two beams with 1% and 2% longitudinal reinforcement ratios and with stirrups were stressed to failure under monotonic loading till failure. Observations of the deflections, crack width and crack appearance were recorded at increasing load intervals until failure. From experimental results, it was discovered that the higher percentage of longitudinal reinforcement exhibited a higher ultimate load capaci

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Yang, Wu, Wen Juan Yao, and Xiao Yu Liu. "Stress Monitoring for the Whole Construction Process of Simply Supported to Continuous T-Beam Bridge." Applied Mechanics and Materials 71-78 (July 2011): 3954–57. http://dx.doi.org/10.4028/www.scientific.net/amm.71-78.3954.

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In order to research on the stress change and influencing factor of whole construction process of simply supported to Continuous system T-beam bridge, combined with Guizhou Bai-long bridge, the stress change is carried out the real time inspection in each construction stage, and the finite element model is established to analyse Stress changes in whole construction process. The monitoring value is more consistent with the theoretical value in each stage , monitoring dates and theoretical calculations showed that pre-stressed is the main factor of stress changes in construction process.Pre-st

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15

Zurita, Amado J., Mehrdad Khajavi, Xuemei Wang, et al. "Plasma cytokines and angiogenic factors (CAFs) associated with risk of recurrence and tumor dependence in patients (pts) with nonmetastatic renal cell carcinoma (RCC)." Journal of Clinical Oncology 30, no. 5_suppl (2012): 383. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.383.

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383 Background: Although recent years have brought great progress into understanding the pathogenesis of RCC and multiple promising biomarkers, no tumor tissue or blood-based test has yet been validated for clinical use. The main objectives of this exploratory analysis were to identify CAFs predictive of recurrence in RCC pts, and to gain insight into tumor dependency of individual factors by comparing CAFs pre- and post-nephrectomy (Nx). Methods: Plasma samples were obtained before and up to 1 year after Nx from pts with sporadic, non-metastatic renal masses suspicious for RCC (n=73). Upon Nx

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16

Hu, Bin, Yingchun Cai, Heng Liu, Wenqi Wu, and Baixue He. "The Stiffness Change in Pre-Stressed Concrete T-Beams during Their Life-Cycle Based on a Full-Scale Destructive Test." Applied Sciences 14, no. 12 (2024): 5200. http://dx.doi.org/10.3390/app14125200.

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In order to study the stiffness degradation of pre-stressed concrete T-beams throughout their entire service life, full-scale destructive tests were conducted on newly constructed T-beams. The test process characterized the relationship between load and deflection at different load levels. Meanwhile, the equivalent stiffness and short-term stiffness of the T-beams at different load levels were calculated based on formulas from the code, and a segmental stiffness back-calculation method for pre-stressed concrete T-beam bridges was proposed based on system identification theory. The results show

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17

Khajavi, Mehrdad, Eric Jonasch, Xuemei Wang, et al. "Plasma cytokines and angiogenic factors (CAFs) for evaluation of risk of recurrence and classification of patients (pts) with nonmetastatic renal cell carcinoma (RCC)." Journal of Clinical Oncology 30, no. 15_suppl (2012): e15075-e15075. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e15075.

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e15075 Background: Although recent years have brought great progress into understanding the pathogenesis of RCC and multiple promising biomarkers, no tumor tissue or blood-based test has yet been established to assist in the clinical determination of prognosis. Whether CAFs can be used to classify RCC pts and the set of CAFs that is host vs. tumor-dependent remain unclear. The main objectives of this exploratory analysis were to identify CAFs predictive of recurrence, and to gain insight into coordinated regulation and tumor dependency of individual factors by comparing CAFs pre- and post-neph

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18

Takahashi, Yoshiyuki, Othon Mena, Ramaprasad Srinivasan, et al. "Cd8+ T-Cells Specifically Cytotoxic to Renal Cell Carcinoma (RCC) Cells Can Be Isolated from Patients with Regressing Metastatic Kidney Cancer after Allogeneic Nonmyeloablative Hematopoietic Cell Transplantation (NMHCT)." Blood 104, no. 11 (2004): 4984. http://dx.doi.org/10.1182/blood.v104.11.4984.4984.

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Abstract Graft-vs-tumor (GVT) effects following NMHCT induce disease regression in a subset of patients (pts) with advanced metastatic kidney cancer. At present, little is known about the antigens serving as tumor targets in responding pts. In an effort to characterize GVT effectors and their tumor antigens, we generated RCC cell lines to use as targets in cytotoxicity assays in three pts (one non-responder and two responders) undergoing a cyclophosphamide/fludarabine-based NMHCT from HLA matched siblings. Peripheral blood lymphocytes (PBL) were collected from pts at multiple time-points after

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19

Zhou, Haijun, Xuan Qi, Zhidong Liu, et al. "Asymmetric Cantilever Construction Control of a U-Shaped Box Concrete Continuous Bridge in Complex Environment." Buildings 13, no. 3 (2023): 591. http://dx.doi.org/10.3390/buildings13030591.

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The bridge of Shanghai Metro Line 10 over Metro Line 6 is a U-shaped concrete single-box double-cell concrete box beam continuous bridge. A novel method is applied to construct the asymmetric cantilever prefabricated and assembled continuous bridge due to the limited construction space and the complex environment. Four mechanical state control methods are applied during the T-shape structure construction process: tensioning pre-stressed steel strand, jacking by the axial force servo system, adjusting the leg reaction force, and setting the auxiliary leg. Auxiliary measures such as the compress

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20

Bui Thanh, Danh, Cuong Nguyen Van, and Vinh Nguyen Van. "Research on the influence of dynamic parameters on the operation process of gantry cranes with assembled structures on the cap of bridge pier to serve installation of Super –T beams." EUREKA: Physics and Engineering, no. 3 (May 27, 2024): 107–20. http://dx.doi.org/10.21303/2461-4262.2024.003253.

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The gantry crane, positioned atop the bridge pier cap for the installation of Super-T girders, is a specialized construction unit within the bridge construction industry. The article presents a summary of research results investigating dynamic parameters and their influence on the operation of gantry cranes with assembled structures on the cap of bridge piers, serving the installation of Super-T beams in two scenarios: lifting with pre-stressed cable and moving with load (Super-T beam). To examine the dynamic parameters affecting the operation of the gantry crane, the authors first constructed

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21

Hanchate, Ms Ashwini. "Effect of Skew Angles on Longitudinal Girder and Deck Slab of Prestressed Concrete T Beam Girder Bridges." International Journal for Research in Applied Science and Engineering Technology 9, no. 10 (2021): 414–20. http://dx.doi.org/10.22214/ijraset.2021.38432.

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Abstract: The present paper shows the effects of varying skew angles on pre-stressed concrete (PSC) bridges using finite elemental method. Studies are carried out on PSC bridge decks to understand the influence of skew angle and loading on behaviour of bridges. The results of skewed bridges are compared with straight bridges for IRC Class AA Tracked loading. Also, a comparative analysis of the response of skewed PSC Slab Bridge decks with that of equivalent straight bridge decks is made. The variation of maximum longitudinal bending moment (BM), maximum transverse moment, maximum torsional mom

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Boi, Shannon Kathryn, Rachael M. Orlandella, and Lyse A. Norian. "Improving immunotherapeutic efficacy against metastatic tumors in a pre-clinical model of murine renal cell carcinoma." Journal of Immunology 198, no. 1_Supplement (2017): 79.9. http://dx.doi.org/10.4049/jimmunol.198.supp.79.9.

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Abstract Renal and pelvic cancers are the ninth most common cancer in the U.S., and although five-year survival rates for localized renal tumors are &gt;90%, those for metastasized tumors are &lt;12%. Metastatic renal cell carcinoma (RCC), the most common type of renal neoplasm, is resistant to radio- and chemotherapies. Immune-based therapies, including checkpoint blockade, are being pursued in an attempt to amplify protective adaptive immunity but overall response rates remain at 20–30%. We hypothesized that a therapeutic strategy employing T cell priming plus checkpoint blockade wou

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Ahmad, Seleem, Ghada Gamiaa, and Abd El-Monem El-Kholy. "The effect of beam width and crack-depth ratio on mode I fracture toughness of RCB: an experimental and numerical study." Frattura ed Integrità Strutturale 18, no. 67 (2023): 24–42. http://dx.doi.org/10.3221/igf-esis.67.03.

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In the present work, the fracture performance of pre-cracked reinforced concrete beams was investigated numerically and experimentally. Experimental and numerical programs were designed to examine the effect of beam width, b, (120 and 250 mm) and crack-to-depth ratio, a/d, (0.1, 0.2 and 0.3) for concrete strength, fc, (40 MPa), on the behavior of stress intensity factor, K1C, and fracture energy, G, for reinforced concrete, RC, beams. The work utilized beams with three-point loading conditions experimentally. Through the use of the ANSYS program, a comprehensive 3-D finite element analysis was

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24

Potez, Marine, Mohammed Alkhouli, Johannes Ali, et al. "Abstract B023: Using hypoxia to improve tumor infiltrating lymphocytes therapy in different subtypes of renal cell carcinoma." Cancer Research 83, no. 16_Supplement (2023): B023. http://dx.doi.org/10.1158/1538-7445.kidney23-b023.

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Abstract BACKGROUND: Improving the long-term efficacy for advanced renal cell carcinoma (RCC) remains challenging after progression on first line therapy. Adoptive cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) is a promising personalized immunotherapeutic approach to treating solid tumors. Previously, TIL therapy for clear cell RCC patients showed moderate success but did not account for the distinct immune microenvironments in different subtypes of RCC such as clear cell (ccRCC), papillary (pRCC) or unclassified (uRCC) known to have different response to immunotherapy. In addi

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25

Corre, Isabelle, Manuel Gomez, Susina Vielkind, and Doreen A. Cantrell. "Analysis of Thymocyte Development Reveals That the Gtpase Rhoa Is a Positive Regulator of T Cell Receptor Responses in Vivo." Journal of Experimental Medicine 194, no. 7 (2001): 903–14. http://dx.doi.org/10.1084/jem.194.7.903.

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Loss of function of the guanine nucleotide binding protein RhoA blocks pre-T cell differentiation and survival indicating that this GTPase is a critical signaling molecule during early thymocyte development. Previous work has shown that the Rho family GTPase Rac-1 can initiate changes in actin dynamics necessary and sufficient for pre-T cell development. The present data now show that Rac-1 actions in pre-T cells require Rho function but that RhoA cannot substitute for Rac-1 and induce the actin cytoskeletal changes necessary for pre-T cell development. Activation of Rho is thus not sufficient

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26

Kashima, Soki, Zhaochen Ye, Alia Meliki, et al. "Investigation of T cell phenotypes associated with response or resistance to immune checkpoint inhibitors (ICI) through single-cell analysis of renal cell carcinoma (RCC)." Journal of Clinical Oncology 42, no. 16_suppl (2024): 4515. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.4515.

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4515 Background: RCC is notable for a high CD8+ T cell infiltration despite its modest tumor mutational load. However, CD8+ T cell infiltration does not correlate with ICI response, highlighting the need to understand cellular composition and phenotype. We conducted a comprehensive dissection of the tumor microenvironment (TME) using pre- and post-ICI treatment samples to identify specific T-cell populations associated with ICI treatment efficacy in RCC. Methods: A total of 70 tumor samples (n = 59 clear cell; n = 11 non-clear cell) from 63 patients with RCC were collected before (n = 48) and/

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Cesana, Giovanni C., Gail DeRaffele, Seth Cohen, et al. "Characterization of CD4+CD25+ Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma." Journal of Clinical Oncology 24, no. 7 (2006): 1169–77. http://dx.doi.org/10.1200/jco.2005.03.6830.

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Purpose To characterize the number and functional status of CD4+CD25+ regulatory T cells (Tregs) in patients with metastatic melanoma (MM) and renal cell carcinoma (RCC) treated with high-dose bolus interleukin-2 (IL-2). Patients and Methods Patients with MM or RCC treated with high-dose bolus IL-2 (600,000 IU/kg every 8 hours) at a single center provided pre- and post-treatment whole blood specimens. Peripheral blood mononuclear cells were isolated by Ficoll density gradient centrifugation, separated into cellular subsets, and analyzed by flow cytometry or used for in vitro proliferation assa

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Dumaswala, U. J., L. Zhuo, S. Mahajan, et al. "Glutathione protects chemokine-scavenging and antioxidative defense functions in human RBCs." American Journal of Physiology-Cell Physiology 280, no. 4 (2001): C867—C873. http://dx.doi.org/10.1152/ajpcell.2001.280.4.c867.

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Oxidant stress, in vivo or in vitro, is known to induce oxidative changes in human red blood cells (RBCs). Our objective was to examine the effect of augmenting RBC glutathione (GSH) synthesis on 1) degenerative protein loss and 2) RBC chemokine- and free radical-scavenging functions in the oxidatively stressed human RBCs by using banked RBCs as a model. Packed RBCs were stored up to 84 days at 1–6°C in Adsol or in the experimental additive solution (Adsol fortified with glutamine, glycine, and N-acetyl-l-cysteine). Supplementing the conventional additive with GSH precursor amino acids improve

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Aydinok, Yesim, Antonio Piga, Raffaella Origa, et al. "Hemoglobin Utilization in Asplenic and Non-Splenectomized Transfusion Dependent Thalassemia Patients Supported with Pathogen Reduced Red Blood Cell Concentrates in a Phase 3 Study (SPARC)." Blood 132, Supplement 1 (2018): 3812. http://dx.doi.org/10.1182/blood-2018-99-112685.

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Abstract Introduction: Transfusion dependent thalassemia (TDT) requires regular transfusion of red cell concentrates (RBCC) to prevent the complications of anemia and excessive erythroid expansion. Despite donor testing, long-term transfusion has a substantial cumulative risk of transfusion-transmitted infection (TTI) due to undetected viruses, bacteria, and protozoa. Splenectomized (-S) TDT patients may have greater TTI morbidity than patients with spleens (+S); but may benefit from reduced use of red blood cell concentrates (RBCC) and reduced transfusion iron (Fe) loading. Pathogen reduction

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Zahoor, Haris, Paul G. Pavicic, Christopher Przybycin, et al. "T cell infiltration in matched renal biopsy (bx) and nephrectomy (nx) samples in renal cell carcinoma (RCC)." Journal of Clinical Oncology 35, no. 6_suppl (2017): 472. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.472.

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472 Background: T cell infiltration in tumors has been investigated as a biomarker of response to checkpoint inhibitors. A neo-adjuvant trial of checkpoint inhibition in locally-advanced RCC is ongoing at Cleveland Clinic, where T cell infiltration in pre-treatment renal mass bx will be compared to post-treatment nx specimens. However, there are no data regarding the association of T cell infiltration in matched bx and nx samples without intervening treatment. Understanding this association will enable further study of this potential biomarker in future neo-adjuvant studies. Methods: Matched b

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He, Hua Nan, and Wei Dong. "Study on Damaged Reinforced Concrete Beams Strengthened with Basalt Fiber Polymer Sheets." Advanced Materials Research 446-449 (January 2012): 2941–44. http://dx.doi.org/10.4028/www.scientific.net/amr.446-449.2941.

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In practical concrete structures, once reinforced concrete beams serve in case of over cracking or are even damaged due to sudden overloading, it is necessary to repair or strengthened the damaged members for purpose of restoring the structural capacities and keeping the structures working well. At present FRP strengthening technique is one of the most accepted methods available in civil engineering. This paper particularly presents a new FRP material，basal fiber, which is applied to strengthen flexural behaviors of reinforced concrete beams suffering from different amplitudes of cracking dama

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32

Braun, D. P., D. M. Johnson, N. G. Katsantonis, K. Bhesaniya, and E. D. Staren. "Apoptotic and immunomodulatory effects of green tea extracts (GTE) on chemoresistant human tumor cells." Journal of Clinical Oncology 27, no. 15_suppl (2009): e22101-e22101. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e22101.

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e22101 Background: GTE and Epigallocatechin 3-gallate (EGCG), the most abundant polyphenol in GTE, have been shown to exert inhibitory effects on carcinogenesis; modulatory effects on tumor proliferation and differentiation; and immunomodulatory effects on tumor immunity in different pre-clinical models. These pluripotent effects suggest that GTE may have clinical activity that could be exploited for treatment of chemo-insensitive but immunologically responsive tumors. Thus, the present study investigated the effects of EGCG on the proliferation and immunologic sensitivity of human renal cell

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Carlisle, Jennifer Wilkinson, Caroline S. Jansen, Maria Andrea Cardenas, et al. "Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood." Journal for ImmunoTherapy of Cancer 10, no. 7 (2022): e004803. http://dx.doi.org/10.1136/jitc-2022-004803.

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PurposeCheckpoint therapy is now the cornerstone of treatment for patients with renal cell carcinoma (RCC) with advanced disease, but biomarkers are lacking to predict which patients will benefit. This study proposes potential immunological biomarkers that could developed for predicting therapeutic response in patients with RCC.MethodsUsing flow cytometry, RNA sequencing, and T-cell receptor (TCR) sequencing, we investigated changes in T cells in the peripheral blood of patients with advanced RCC after receiving immunotherapy. We used immunofluorescence (IF) imaging and flow cytometry to inves

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Zahoor, Haris, Paul G. Pavicic, Christopher Przybycin, et al. "T cell infiltration (TCI) in matched renal biopsy (bx) and nephrectomy (nx) samples in renal cell carcinoma (RCC)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 4587. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.4587.

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4587 Background: TCI in tumors has been investigated as a biomarker of response to checkpoint inhibitors. A neo-adjuvant trial of checkpoint inhibition in locally-advanced RCC is ongoing at Cleveland Clinic, where TCI in pre-treatment renal mass bx will be compared to post-treatment nx specimens. However, there are no data regarding the association of TCI in matched bx and nx samples without intervening treatment. Understanding this association will enable further study of this potential biomarker in future studies. Methods: Matched bx and nx samples (without intervening systemic therapy) were

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Miao, Ji Jun, Qiong Qiong Zhu, Yan Chun Liu, Bo Qi, and Dian Wu Wang. "Experimental Research and Numerical Analysis on the Law of Deteriorated Performance for R.C. Frame Structure with Seismic Damages under Elevated Temperature (part II)." Applied Mechanics and Materials 71-78 (July 2011): 1648–55. http://dx.doi.org/10.4028/www.scientific.net/amm.71-78.1648.

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The cracks were pre-settled to the R.C. frame structure caused by earthquake which was defined as the damage index ω during the modeling process with analysis software-ANASYS. The temperature field contour curve were calculated for the column and beam, the law of deteriorated bearing capacity with time for the R.C. frame structure under elevated temperature were brought forward，which can adapt to R.C. frame structure with different damage index ω caused by earthquake.The relationship between ω and deteriorated bearing capacity for R.C. frame structure was also given, which was proved to be eff

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Gomez, Manuel, Victor Tybulewicz, and Doreen A. Cantrell. "Control of pre-T cell proliferation and differentiation by the GTPase Rac-1." Nature Immunology 1, no. 4 (2000): 348–52. http://dx.doi.org/10.1038/79808.

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Giannakis, Marios, Haoxin Li, Chelsea Jin, et al. "Metabolomic correlates of response in nivolumab-treated renal cell carcinoma and melanoma patients." Journal of Clinical Oncology 35, no. 15_suppl (2017): 3036. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.3036.

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3036 Background: Immune-checkpoint inhibition has been shown to be effective in a variety of cancers, including renal cell carcinoma (RCC) and melanoma. However, only a subset of patients with RCC and melanoma respond to anti-PD1 therapy. Given the importance of metabolism in the tumor immune microenvironment, we performed serum metabolomics in nivolumab-treated patients towards identifying novel non-invasive correlates of response and progression-free survival in immunotherapy-treated patients. Methods: We performed liquid chromatography-mass spectrometry on pre- and on-treatment serum sample

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Halbert, Brian, David Einstein, David McDermott, et al. "176 Successful generation of tumor-infiltrating lymphocyte (TIL) product from renal cell carcinoma (RCC) tumors for adoptive cell therapy." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A188. http://dx.doi.org/10.1136/jitc-2021-sitc2021.176.

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BackgroundPatients with RCC may achieve remission with immune-checkpoint inhibitors (ICI); however, most patients will progress. Adoptive cell therapy with autologous TIL allows for expansion of T-cells from tumor tissue leading to a polyclonal T-cell product with a diverse T-cell receptor repertoire capable of recognizing an array of tumor antigens. TIL therapy with centrally manufactured lifileucel demonstrated a 36% overall response rate in patients with ICI-refractory melanoma.1 We present our preclinical experience of TIL production in RCC.MethodsThis study was approved by the DF/HCC Inst

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Vats, Pankaj, Saravana Dhanasekaran, Rohit Malik, et al. "Integrative genomic profiling of RCC treated with second-line nivolumab." Journal of Clinical Oncology 38, no. 6_suppl (2020): 720. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.720.

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720 Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer comprising up to 80% of RCC. Anti-vascular endothelial growth factor receptor (VEGFR) is a common therapy. Immune checkpoint inhibitor therapy with anti-PD1 antibody Nivolumab is a standard second line option in mccRCC. Overall response rate with Nivolumab however is only 25%. Since there is a critical need to develop and refine predictive biomarkers for anti-PD1 checkpoint inhibitor immunotherapy, we undertook a genomics based approach to gain further insights. Methods: Archival pre-treatment t

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Tumlin, Kimberly I., Elizabeth N. Riley, Olga Vsevolozhskaya, and Michael Cull. "Lower Emotional Exhaustion among Employees Is Associated with Intentional Incorporation of Animals into Residential Care Settings." Behavioral Sciences 13, no. 5 (2023): 421. http://dx.doi.org/10.3390/bs13050421.

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Secondary effects of animal-integrated programming on residential care center (RCC) staff and organizational culture are not well understood. We explored emotional exhaustion among RCC employees both in facilities that incorporated animals and those that did not incorporate animals into the therapeutic environment. We conducted a survey throughout a large midwestern RCC system in the United States to determine relationships between organizational culture, emotional exhaustion, and the intentionality by which animals were incorporated into programming. Data were analyzed by examining associatio

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Morsy, Alaa M., El-Tony M. El-Tony, and Mohamed El-Naggar. "Flexural repair/strengthening of pre-damaged R.C. beams using embedded CFRP rods." Alexandria Engineering Journal 54, no. 4 (2015): 1175–79. http://dx.doi.org/10.1016/j.aej.2015.07.012.

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Alkhouli, Mohammed, Veronica Martinez-Brockhus, Matthew S. Beatty, Robert J. Gillies, Shari Pilon-Thomas, and Jad Chahoud. "Abstract 575: Ex vivo expansion of tumor infiltrating lymphocytes (TIL) from human renal cell carcinoma (RCC) tumors." Cancer Research 82, no. 12_Supplement (2022): 575. http://dx.doi.org/10.1158/1538-7445.am2022-575.

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Abstract In this study, we evaluated the feasibility of expanding tumor infiltrating lymphocytes (TIL) from surgically resected renal cell carcinoma (RCC) tumors. Tumors were collected from 43 patients undergoing surgery to remove primary kidney tumors. Tumor types included clear cell RCC (86.0%), papillary RCC (11.6%) as well as chromophobe RCC (2.3%). Tumors were minced into fragments, placed in individual wells of a 24-well plate containing media with high dose IL-2 (6000 IU/mL), and cultured for four weeks. Successful expansion was considered when at least one fragment expanded to a minimu

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Sun, Jian-Xuan, Chen-Qian Liu, Zong-Biao Zhang, et al. "A Novel Predictive Model of Pathological Lymph Node Metastasis Constructed with Preoperative Independent Predictors in Patients with Renal Cell Carcinoma." Journal of Clinical Medicine 12, no. 2 (2023): 441. http://dx.doi.org/10.3390/jcm12020441.

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Introduction: Renal cell carcinoma (RCC) is one of the most common urinary tumors. The risk of metastasis for patients with RCC is about 1/3, among which 30–40% have lymph node metastasis, and the existence of lymph node metastasis will greatly reduce the survival rate of patients. However, the necessity of lymph node dissection is still controversial at present. Therefore, a new predictive model is urgently needed to judge the risk of lymph node metastasis and guide clinical decision making before operation. Method: We retrospectively collected the data of 189 patients who underwent retroperi

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Patil, Dattatraya H., Ella N. Anastasiades, Mersiha Torlak, et al. "Evaluation of serial measurements of C-reactive protein: Albumin ratio in patients with clear cell renal cell carcinoma." Journal of Clinical Oncology 36, no. 6_suppl (2018): 695. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.695.

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695 Background: Sequential measurements of prognostic markers is an important protocol for accurate prediction of clinical outcomes in clear cell RCC. We propose that change in value of C-Reactive Protein to albumin ratio before and after surgery would be a good prognostic indicator for assessment of overall survival and risk stratification in clear cell RCC. Methods: Patients that underwent nephrectomy for clear cell RCC between 2007 and 2016 were followed up with CRP-Albumin measurements for 3 post-op visits (1, 3, 6 months). All measurements between post-op day 1 to 21 were excluded from an

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Fonteyne, Valérie, Willeke Danckaert, Piet Ost, et al. "Dosimetric and Hematologic Implications of Prostate-Only Versus Whole Pelvic Radiotherapy: Results of the Multicentric Phase 3 PROPER Study." Technology in Cancer Research & Treatment 22 (January 2023): 153303382311540. http://dx.doi.org/10.1177/15330338231154088.

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Objectives: The aim is to evaluate the incidental dose to the lymphatic regions in prostate-only radiotherapy (PORT) and to compare hematological outcome between PORT and whole pelvic radiotherapy (WPRT) in node-positive prostate cancer (pN1 PCa), in the era of modern radiotherapy techniques. Methods: We performed a prospective phase 3 trial in which a total of 64 pN1 PCa patients were randomized between PORT (ARM A) and WPRT (ARM B) delivered with volumetric-modulated arc therapy (VMAT). The lymph node (LN) regions were delineated separately and differences between groups were calculated usin

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Haywood, Samuel, Roy Chen, Paul Pavicic, et al. "Sunitinib's effect on tumor infiltration of CD8 T cells in renal cell carcinoma (RCC) and modulation of their function by altering VEGF-induced upregulation of PD1 expression." Journal of Clinical Oncology 34, no. 2_suppl (2016): 591. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.591.

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591 Background: The effect of VEGF inhibitors such as sunitinib to modulate RCC tumor microenvironment and the effect on immunotherapy using checkpoint inhibitors is unknown and of clinical interest. Methods: Immune infiltrate in tissue sections from clear cell renal cell carcinomas (ccRCC) (n = 13) treated with sunitinib in the neoadjuvant setting were compared to that of untreated RCC patients with localized disease (n = 15). Immune infiltrate was scored in H&E stained tissue sections. Infiltrates were further characterized by IHC using antibodies against CD4 (Novocastra NCL-CD4-1F6 clon

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Greenberg, Jacob W., Hogyoung Kim, Ahmed A. Moustafa, Pedro C. Barata, Asim Abdel-Mageed, and L. Spencer Krane. "A dual drug therapy for sunitinib resistant RCC: An in vitro analysis." Journal of Clinical Oncology 39, no. 6_suppl (2021): 340. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.340.

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340 Background: Over the last decade, medical treatment for metastatic renal cell carcinoma has made significant advances through the development of tyrosine kinase inhibitors (TKI) like sunitinib. However, of patients initiated on TKI therapy, 70% respond well while 30% are believed to be primarily resistant to treatment. Additionally, 30% of patients who initially respond to treatment gain secondary drug resistance and present with increased tumor burden. In this study, we seek to develop a combination therapy of Tipifarnib + Sunitinib to target exosome conferred drug resistance. Methods: 78

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Dumont, Celine, Agnieszka Corsoni-Tadrzak, Sandra Ruf, et al. "Rac GTPases play critical roles in early T-cell development." Blood 113, no. 17 (2009): 3990–98. http://dx.doi.org/10.1182/blood-2008-09-181180.

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Abstract The Rac1 and Rac2 GTPases play important roles in many processes including cytoskeletal reorganization, proliferation, and survival, and are required for B-cell development. Previous studies had shown that deficiency in Rac2 did not affect T-cell development, whereas the function of Rac1 in this process has not been investigated. We now show that simultaneous absence of both GTPases resulted in a very strong developmental block at the pre-TCR checkpoint and in defective positive selection. Unexpectedly, deficiency of Rac1 and Rac2 also resulted in the aberrant survival of thymocytes l

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Erickson, A. C., V. A. Lee, M. A. Schott, G. M. Castro, T. Peterson, and A. North. "A Modified Process for Preparation of Pathogen Inactivated RBC Using S-303 in Multiple Additive Solutions Maintains RBC Function and Reduces Immunologic Activity." Blood 108, no. 11 (2006): 943. http://dx.doi.org/10.1182/blood.v108.11.943.943.

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Abstract Background: Treatment of RBC with S-303 (acridine derivative) inactivates pathogens and leukocytes. The original process for S-303 treatment of RBC (oSRBC) for pathogen inactivation (PI) used 0.2mM S-303 and 2mM glutathione (GSH). Two randomized, controlled Phase III trials were voluntarily discontinued when antibodies, specific to residual acridine on oSRBC, were detected in 2 patients. Following this observation, a modified PI process using 0.2mM S-303 and 20mM GSH (mSRBC) was developed to reduce S-303 binding to the RBC surface which inactivates a broad spectrum of pathogens and ma

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Harnett, James, Elizabeth A. MacLean, Helen Bhattacharyya, Laura A. Cisar, Caroline Hoang, and Jack Mardekian. "Sunitinib and pazopanib treatment patterns and cost outcomes in Medicare supplemental-covered patients with renal cell carcinoma." Journal of Clinical Oncology 33, no. 7_suppl (2015): 485. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.485.

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485 Background: Few studies compare targeted treatments for renal cell carcinoma (RCC) so understanding real world treatment patterns and healthcare utilization may inform decision making. This study evaluated treatment naïve RCC patients initiating sunitinib (SUN) or pazopanib (PAZ) and the potential impact of administration schedules on duration of therapy (persistence) assessments using claims data. Methods: This retrospective cohort analysis used de-identified Truven Marketscan Medicare Supplemental claims data. Included patients were ≥20 years, diagnosed with RCC with ≥1 prescription (Rx)

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