To see the other types of publications on this topic, follow the link: RDI 560.
Journal articles on the topic 'RDI 560'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'RDI 560.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Al-Attiyah, R., and A. S. Mustafa. "Characterization of Human Cellular Immune Responses to Novel Mycobacterium tuberculosis Antigens Encoded by Genomic Regions Absent in Mycobacterium bovis BCG." Infection and Immunity 76, no. 9 (2008): 4190–98. http://dx.doi.org/10.1128/iai.00199-08.
Full textAbstract:
ABSTRACT Comparative genomics has identified several regions of differences (RDs) between the infectious Mycobacterium tuberculosis and the vaccine strains of Mycobacterium bovis BCG. We aimed to evaluate the cellular immune responses induced by antigens encoded by genes predicted in 11 RDs. Synthetic peptides covering the sequences of RD1, RD4 to RD7, RD9 to RD13, and RD15 were tested for antigen-induced proliferation and secretion of Th1 cytokine, gamma interferon (IFN-γ), by peripheral blood mononuclear cells (PBMC) obtained from culture-proven pulmonary tuberculosis (TB) patients and M. bovis BCG-vaccinated healthy subjects. Among the peptide pools, RD1 induced the best responses in both donor groups and in both assays. In addition, testing of TB patients' PBMC for secretion of proinflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin 6 [IL-6], IL-8, and IL-1β), Th1 cytokines (IFN-γ, IL-2, and TNF-β), and Th2 cytokines (IL-4, IL-5, and IL-10) showed differential effects of RD peptides in the secretion of IFN-γ and IL-10, with high IFN-γ/IL-10 ratios (32 to 5.0) in response to RD1, RD5, RD7, RD9, and RD10 and low IFN-γ/IL-10 ratios (<1.0) in response to RD12, RD13, and RD15. Peptide-mixing experiments with PBMC from healthy subjects showed that secretion of large quantities of IL-10 in response to RD12 and RD13 correlated with inhibition of Th1 responses induced by RD1 peptides. In conclusion, our results suggest that M. tuberculosis RDs can be divided into two major groups—one group that activates PBMC to preferentially secrete IFN-γ and another group that activates preferential secretion of IL-10—and that these two groups of RDs may have roles in protection against and pathogenesis of TB, respectively.
2
Ishizawa, Kenichi, Kensuke Usuki, Kiyoshi Ando, et al. "Multicenter, Open-Label Phase I Clinical Study of Oral Rigosertib in Japanese Patients with Recurrent/Relapsed or Refractory Myelodysplastic Syndromes: Tolerability, Efficacy, and Pharmacokinetic Profiles." Blood 128, no. 22 (2016): 5538. http://dx.doi.org/10.1182/blood.v128.22.5538.5538.
Full textAbstract:
Abstract Background:Rigosertib is a novel phosphoinositide 3 kinase pathway inhibitor that induces G2/M arrest leading to the apoptosis of cancer cells and myeloblasts and causes minimal damage to normal cells. A Phase I study in the U.S. showed the safety and good tolerability of oral rigosertib in patients (pts) with low, intermediate-1, intermediate-2, or high risk myelodysplastic syndromes (MDS). Methods:A multicenter, open-label Phase I clinical study was conducted to examine the tolerability of oral rigosertib in Japanese pts with recurrent/relapsed or refractory MDS, and to determine the recommended dose for a Phase II clinical study. The key eligibility criteria were as follows: patients with recurrent/relapsed or refractory MDS, aged 20 years or older, ECOG PS of 0 to 2, and no major organ dysfunctions. Rigosertib (280 and 560 mg BID) was administered orally in one 21-day cycle that consisted of the 14-day, twice-daily, oral administration term, followed by the 7-day monitoring term. In principle, oral rigosertib was administered in up to cycle 6. The primary endpoint was the dose-limiting toxicity (DLT) in each dose group. The secondary endpoints were as follows: 1) safety as assessed with adverse events (AEs) and laboratory results; 2) efficacy as assessed according to the International Working Group 2006 criteria; and 3) pharmacokinetics. Results: Between March 2013 and November 2014, 10 patients were enrolled at 7 medical institutions in Japan. However, 1 of them did not receive rigosertib because of a tendency for PS deterioration. Six pts were male, the median age was 70 years (range 52 to 80 years), and ECOG PS was 0 in 7 pts and was 1 in 2 pts. Consequently, 3 and 6 pts were eventually assigned to the 280 and 560 mg dose groups, respectively. According to the FAB classification, 4, 2, 2, and 1 pts were categorized to RAEB, RARS, RA, and RAEB-t, respectively. The prognostic factor according to IPSS was Int-1 risk in 4 pts (1 and 3 pts in the 280 and 560 mg dose groups, respectively) and was Int-2 in 5 pts (2 and 3 pts in the 280 and 560 mg dose groups, respectively). In the 280 mg dose group, 2 of 3 pts completed cycle 6, and the median relative dose intensity (RDI) was 86% (77 to 92%). In the 560 mg dose group, the maximum number of cycles delivered was 4, and the median RDI was 85% (68 to 93%). A total of 57 AEs developed. In the 280 mg dose group, grade 3 or higher nonhematologic toxicities, grade 3 type 2 diabetes mellitus, and grade 4 delirium (1/3, 33.3%) developed. In the 560 mg dose group, grade 3 AEs: cholecystitis, periodontitis, pneumonia, soft tissue infection, increased alanine aminotransferase, increased aspartate aminotransferase, and prolonged QT interval, as well as grade 5 urinary tract infection (1/6, 16.7%) developed. DLTs (all of which were grade 3 or higher nonhematologic toxicities) were observed with 1 of 3 pts in the 280 mg dose group (type 2 diabetes mellitus and delirium) and with 2 of 6 pts in the 560 mg dose group (urinary tract infection and prolonged QT interval). Serious AEs were 2 events in 1 of 3 pts in the 280 mg dose group (type 2 diabetes mellitus and delirium) and were 6 events in 3 of 6 pts in the 560 mg dose group (soft tissue infection, periodontitis, cholecystitis, and pneumonia in 1 pt, hematuria in 1 pt, and urinary tract infection in 1 pt). One pt in the 560 mg dose group died of septic shock that had been caused by a urinary tract infection during the study period. The hematological remission rate was 11.1% (1 marrow CR; 1/9 pts), and the hematological improvement rate was 11.1% (1 HI-P; 1/9 pts); however, cytogenetic response was not found. Plasma concentrations of rigosertib increased rapidly after each oral administration. Among the PK parameters, intersubject variability was observed in the maximum plasma concentration (Cmax) and the area under the plasma concentration-time curve (AUC). However, changes suggesting the accumulation of rigosertib during repeated oral administration (e.g., consistent increases in the Cmax and AUC) were not found. The urinary excretion rates of rigosertib on day 1 were 1.6 ± 1.0% and 11.0 ± 6.6% (mean ± SD) in the 280 and 560 mg dose groups, respectively. Conclusions: The present chemotherapy regimen of oral rigosertib was well tolerated. Our study indicates that the recommended dose for a Phase II clinical study is 560 mg BID in Japanese patients with recurrent/relapsed or refractory MDS. Disclosures Ishizawa: SymBio Pharmaceuticals: Research Funding. Usuki:Nippon Shinyaku: Honoraria; Sumitomo Dainippon Pharma: Honoraria; MSD: Honoraria; Kyouwa-Kirin: Honoraria; Novartis: Honoraria; Bristol-Myer-Squibb: Honoraria; SymBio Pharmaceuticals: Research Funding. Ando:SymBio Pharmaceuticals: Research Funding. Ueda:SymBio Pharmaceuticals: Research Funding. Uike:SymBio Pharmaceuticals: Research Funding. Onishi:SymBio Pharmaceuticals: Research Funding. Iida:SymBio Pharmaceuticals: Research Funding.
3
Tortola, Marco, Ihsan S. Al-Aasm, and Richard Crowe. "Diagenetic Pore Fluid Evolution and Dolomitization of the Silurian and Devonian Carbonates, Huron Domain of Southwestern Ontario: Petrographic, Geochemical and Fluid Inclusion Evidence." Minerals 10, no. 2 (2020): 140. http://dx.doi.org/10.3390/min10020140.
Full textAbstract:
Core samples from two deep boreholes were analyzed for petrographic, stable and Sr isotopes, fluid inclusion microthermometry and major, minor, trace and rare-earth elements (REE) of different types of dolomite in the Silurian and Devonian carbonates of the eastern side of the Michigan Basin provided useful insights into the nature of dolomitization, and the evolution of diagenetic pore fluids in this part of the basin. Petrographic features show that both age groups are characterized by the presence of a pervasive replacive fine-crystalline (<50 µm) dolomite matrix (RD1) and pervasive and selective replacive medium crystalline (>50–100 µm) dolomite matrix (RD2 and RD3, respectively). In addition to these types, a coarse crystalline (>500 µm) saddle dolomite cement (SD) filling fractures and vugs is observed only in the Silurian rocks. Results from geochemical and fluid inclusion analyses indicate that the diagenesis of Silurian and Devonian formations show variations in terms of the evolution of the diagenetic fluid composition. These fluid systems are: (1) a diagenetic fluid system that affected Silurian carbonates and was altered by salt dissolution post-Silurian time. These carbonates show a negative shift in δ18O values (dolomite δ18O average: −6.72‰ VPDB), Sr isotopic composition slightly more radiogenic than coeval seawater (0.7078–0.7087), high temperatures (RD2 and SD dolomite Th average: 110 °C) and hypersaline signature (RD2 and SD dolomite average salinity: 26.8 wt.% NaCl eq.); and (2) a diagenetic fluid system that affected Devonian carbonates, possibly occurred during the Alleghenian orogeny in Carboniferous time and characterized by a less pronounced negative shift in δ18O values (dolomite δ18O average: −5.74‰ VPDB), Sr isotopic composition in range with the postulated values for coeval seawater (0.7078–0.7080), lower temperatures (RD2 dolomite Th average: 83 °C) and less saline signature (RD2 dolomite average salinity: 20.8 wt.% NaCl eq.).
4
Smith, John W., Jessicca Rege, Hina Maniar, James Song, David Cox, and Joyce O'Shaughnessy. "Eribulin mesylate (Erib) plus capecitabine (X) for adjuvant treatment in post-menopausal estrogen receptor–positive (ER+) early-stage breast cancer: Phase II, multicenter, single-arm study." Journal of Clinical Oncology 31, no. 15_suppl (2013): 563. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.563.
Full textAbstract:
563 Background: Erib and X have both shown single agent activity in MBC; and X also has activity in ER+ adjuvant tx. This study was designed to evaluate the feasibility of the combination in the adjuvant setting. Methods: Female pts stage I-II, HER2 negative, ER+ BC received Erib at 1.4 mg/m2 iv D1 and D8 and X at 900 mg/m2 po bid on days 1-14 of 21 day cycle, for 4 cycles. The study was considered feasible if 80% of pts are able to achieve the target relative dose intensity (RDI) of at least 85% of the regimen and lower 95% confidence boundary (LCI) is above 70%. Results: Final results of 67pts enrolled are reported here. 88% pts completed 4 cycles of tx. Pt characteristics: Median age 62 yrs (range 28-80), ECOG 0(90%), stage 2(52%). 64/67 pts were evaluable for feasibility. The study met its primary endpoint demonstrating feasibility rate of 81%(95% LCI:71%) with average RDI of 91%. Results were mainly affected by X dose adjustments (Erib RDI-93%, X RDI-88%). X related dose reductions(24, (36%)), missed doses (57,(85%)) and discontinuations due to AE (11(16%)) were higher compared to that with Erib(14(21%), 5(8%) and 7(10%)), respectively. Most common AEs with dose reductions were gr 3/4 hand foot syndrome (HFS) (12%), neutropenia(8%), neuropathy(8%), and GI disorders(6%); and drug discontinuation were HFS(8%), neutropenia(3%), neuropathy(2%), and GI disorders(3%). Tx related AEs and SAE are reported in the Table. 14(21%) pts had an SAE with 12(18%) requiring hospitalization. Conclusions: Adjuvant tx with the Erib-X combination can be given safely with the majority of the patients able to achieve full dosing regimen. We plan to explore an alternative schedule of X(7wk on/off) with this regimen to see if it will further improve tolerability and the RDI. Clinical trial information: NCT01439282. [Table: see text]
5
von Braun, Christina. "« Le Juif » et « la femme » : deux stéréotypes de l’« autre » dans l’antisémitisme allemand du xixe siècle1." Revue germanique internationale, no. 5 (January 10, 1996): 123–39. http://dx.doi.org/10.4000/rgi.560.
Full text
6
Macario, Kita D., Fabiana M. Oliveira, Vinicius N. Moreira, et al. "Optimization of the Amount of Zinc in the Graphitization Reaction for Radiocarbon AMS Measurements at LAC-UFF." Radiocarbon 59, no. 3 (2016): 885–91. http://dx.doi.org/10.1017/rdc.2016.42.
Full textAbstract:
AbstractThe Radiocarbon Laboratory of the Universidade Federal Fluminense, in Brazil, has been successfully applying the zinc reduction method for graphitization of carbon samples since the development of its early protocols in 2009. Successive methodological research aiming to improve and, ultimately, optimize the precision and accuracy of our results indicates that graphitization temperatures as low as 460°C promote erratic 13C isotopic fractionation, but an approximately constant fractionation of about –5‰ is achieved at 520°C. In this work, we present isotope ratio mass spectrometry (IRMS) δ13C results for 14C reference materials graphitized at 550°C with variable amounts of zinc. Based on the results obtained from the addition of 20, 35, and 50 mg of zinc, we conclude that a slightly lower variation in 13C isotope fractionation during graphitization is obtained with less zinc. Moreover, the average isotopic fractionation is not altered by increasing the graphitization temperature from 520°C to 550°C.
7
Hirakawa, Tsuneaki, Hiroki Yamaguchi, Seiji Gomi, Norio Yokose, Koiti Inokuchi, and Kazuo Dan. "Importance of Relative Dose Intensity for Survival in Diffuse Large B-Cell Lymphoma Patients Treated with CHOP-Like Regimen." Blood 112, no. 11 (2008): 3605. http://dx.doi.org/10.1182/blood.v112.11.3605.3605.
Full textAbstract:
Abstract Diffuse large B-cell lymphoma (DLBCL) is the most frequently occurring Non-Hodgkin lymphoma (NHL). Until recently, CHOP regimen (cyclophosphamide, doxorubicin, vincristine and prednisone delivered on a 21-day cycle) was considered as the standard chemotherapy regimen for DLBCL. Recent data have also shown that combining CHOP with Rituximab (R-CHOP) significantly improves survival in DLBCL. It is recognized that delivery of less than full-dose chemotherapy is associated with poor response and shorter survival times. However it is difficult to keep administration of chemotherapy dose and interval due to several side effects such as myelosuppression, infection, and organ dysfunction. Recently relative dose intensity (RDI) defined as total delivered dose of chemotherapy drug per unit time expressed as a percentage of the target dose, had important roll in the treatment outcome. To determine the importance of RDI, we analyzed achievement of RDI in CHOP-like regimen among DLBCL patients. We retrospectively analyzed 203 DLBCL patients treated with CHOP-like regimen as a first line therapy at Nippon Medical School Hospital and related hospital between January 1, 1996 and December 31, 2007. Median age of the patients was 65.6 years (range, 20.5–90.3) at diagnosis. Median duration of observation was 1.9 years (range, 0.1–11.8). 203 patients were classified as international prognostic index (IPI) as follows; Low-Low Intermediate (L-LI) (n=116), High Intermediate-High (HI-H) (n=86), unknown (n=1). They were treated by CHOP (n=47), R-CHOP (n=100), THP (terahydropyranyladriamycin)-COP (n=6), R-THP-COP (n=50). The median RDI of all patients was 75.2%. Increasing RDI correlated with longer survival time (RDI of 70 to <75%, 75 to 79%, and ≥80%, mean survival was 4.6, 5.0 and 5.2 years, respectively). Comparing the patients of RDI ≥80% with those of <80%, the estimated relapse free survival (RFS) and overall survival (OS) was significantly higher in the former (RFS; 81.7% vs 66.4%, p=0.039, OS; 94.1% vs 74.3%, p=0.005). Results of a multivariate Cox regression analyses revealed that RDI of ≥80% (odds ratio 2.495, p=0.040), IPI of L-LI (odds ratio 3.459, p=0.006) and Rituximab (odds ratio 3.554, p=0.005) were independent prognostic factors for OS. Concerning RFS, IPI of L-LI (odds ratio 2.873, p=0.002) and Rituximab (odds ratio 1.989, p=0.044) were independent prognostic factors. On the other hand, RDI of ≥ 80% showed tendency to longer RFS, but it was not statistically significant (odds ratio 1.747, p=0.094). Subsequently we analyzed the reason for the dose reduction an/or chemotherapy delay. Among the reasons, hematological toxicities and febrile neutropenia (FN) resulted in a reduction of treatment intensity significantly (odds ratio 2.550, p=0.007). Prophylactic use of granulocyte colony-stimulating factor (G-CSF) decreased the risk of neutropenic complications and served as increasing the dose intensity (odds ratio 0.436, p=0.007). We demonstrated that increasing RDI was a important prognostic factor for treating DLBCL using CHOP-like regimen. Moreover, prophylactic use of G-CSF to decrease FN had important role for increasing RDI.
8
Saly-Rousset, Olivier. "Cédric Burgun, La vie consacrée en droit canonique et en droit public français." Revue du droit des religions, no. 4 (October 31, 2017): 206–8. http://dx.doi.org/10.4000/rdr.564.
Full text
9
Richard-Pauchet, Odile. "Eszter Kovacs, La Critique du voyage dans la pensée de Diderot. De la fiction au discours philosophique et politique, Paris, Champion, « Les Dix-Huitièmes siècles », 2015, 280 p. ISBN 978-2-7453-2842-7." Recherches sur Diderot et sur l'Encyclopédie, no. 50 (November 25, 2015): 395–97. http://dx.doi.org/10.4000/rde.5260.
Full text
10
Pujol, Stéphane. "Céline Spector, Éloges de l’injustice. La Philosophie face à la déraison." Recherches sur Diderot et sur l'Encyclopédie, no. 52 (December 1, 2017): 283–86. http://dx.doi.org/10.4000/rde.5560.
Full text
11
Quintili, Paolo. "L’école des Lumières : Diderot et l’éducation." Recherches sur Diderot et sur l'Encyclopédie, no. 53 (December 1, 2018): 55–68. http://dx.doi.org/10.4000/rde.5640.
Full text
12
Moati, Philippe. "Représentations et dynamique sectorielle. Cadre d’analyse et application au secteur de la distribution." Revue d'économie industrielle, no. 142 (August 19, 2013): 147–86. http://dx.doi.org/10.4000/rei.5601.
Full text
13
Blum, Antoinette. "Charles Andler en 1908 : un Germaniste pris entre la France et l'Allemagne." Revue germanique internationale, no. 4 (July 10, 1995): 27–44. http://dx.doi.org/10.4000/rgi.506.
Full text
14
Judet de La Combe, Pierre. "La querelle philologique du mythe. Les termes d'un débat en Allemagne et en France au début du siècle dernier." Revue germanique internationale, no. 4 (July 10, 1995): 55–67. http://dx.doi.org/10.4000/rgi.510.
Full text
15
Bollack, Jean. "La redite. Sur un poème de Paul Celan." Revue germanique internationale, no. 4 (July 10, 1995): 147–56. http://dx.doi.org/10.4000/rgi.520.
Full text
16
Pille, René-Marc. "Chamisso et les Huguenots berlinois. Un lien paradoxal entre l’Emigration et le Refuge." Revue germanique internationale, no. 4 (July 10, 1995): 215–21. http://dx.doi.org/10.4000/rgi.530.
Full text
17
Epstein, Simon. "Les intellectuels mobilisés : notes sur le combat des Juifs allemands dans les années 1928-1933." Revue germanique internationale, no. 5 (January 10, 1996): 67–72. http://dx.doi.org/10.4000/rgi.550.
Full text
18
Geller, Jay. "Le péché contre le sang : la syphilis et la construction de l’identité juive1." Revue germanique internationale, no. 5 (January 10, 1996): 141–64. http://dx.doi.org/10.4000/rgi.562.
Full text
19
Weigel, Sigrid. "La polyphonie de l’autre Traumatisme et désir dans l’autobiographie imaginaire de Bachmann." Revue germanique internationale, no. 5 (January 10, 1996): 165–82. http://dx.doi.org/10.4000/rgi.564.
Full text
20
Santner, Éric L. "« My Own Private Germany » : l’histoire secrète de la modernité chez Daniel Paul Schreber." Revue germanique internationale, no. 5 (January 10, 1996): 183–204. http://dx.doi.org/10.4000/rgi.566.
Full text
21
Makari, George J. "Connaître au sens biblique : La philosophie allemande, Freud et l’énigme de la Femme1." Revue germanique internationale, no. 5 (January 10, 1996): 205–22. http://dx.doi.org/10.4000/rgi.568.
Full text
22
Mavingui, Patrick, Margarita Flores, David Romero, Esperanza Martinez-Romero, and Rafael Palacios. "Generation of Rhizobium strains with improved symbiotic properties by random DNA amplification (RDA)." Nature Biotechnology 15, no. 6 (1997): 564–69. http://dx.doi.org/10.1038/nbt0697-564.
Full text
23
Shayne, Michelle, Eva Culakova, Marek S. Poniewierski, et al. "Dose Intensity and Hematologic Toxicity in Older Cancer Patients Receiving Systemic Chemotherapy." Blood 106, no. 11 (2005): 3124. http://dx.doi.org/10.1182/blood.v106.11.3124.3124.
Full textAbstract:
Abstract Introduction: Controlled clinical trials have provided limited data on hematologic toxicity and dose intensity of chemotherapy in the elderly. This study evaluated patient and treatment characteristics that contributed to hematologic toxicity in older cancer patients. Methods: A prospective study of 115 randomly selected U.S. community oncology practices was undertaken between March 2002 and March 2005 that included 999 consecutive patients age 70 and older. Major malignancies included cancers of lung (26%), colorectal (15%), lymphoma (13%), breast (13%), ovary (9%), genitourinary (7%), other gastrointestinal (6%), other gynecologic (3%) and head and neck (2%). Primary outcome measures included: anemia (Hgb &lt;10 gm/dL), thrombocytopenia (plts &lt;75k/mm3), severe neutropenia (SN) (neutrophils &lt;500 cells/mm3, or WBC count &lt;1000/mm3), febrile neutropenia (FN) and both planned and actual relative dose intensity (RDI) compared to standard regimens. Univariate and multivariate logistic regression analyses were performed to compare the difference among patients age 70–74 (45%), 75–79 (34%), ≥ 80 (21%). Results: Increasing age was associated with lower actual RDI (P&lt;001), although planned RDI did not differ among age groups. Along with reduced actual RDI in elderly patients, progressively fewer SN or FN events (25%, 24%, and 16%, respectively) occurred across chemotherapy cycles (P=0.036). More advanced stage of disease at the time of treatment was associated with fewer SN or FN events in all cycles (35%, 27%, 21%, and 19% for stages 1–4, respectively) (P=0.017) along with lower RDI (P=.041). Use of taxane-containing regimens decreased with advancing age (37%, 34%, 27%, respectively) (P=0.034). Among the 50% of patients receiving ≥ 85% RDI, there was no significant difference in SN or FN based on age group or stage. Use of anthracycline-containing regimens was associated with development of SN or FN compared to non-anthracycline regimens (P&lt;0.001). Older patients who received ≥ 85% actual RDI experienced more frequent SN or FN in all cycles of chemotherapy (27%) compared with patients who received &lt;85% (22%) (P=.041) although no significant increase with age was observed. There was no statistically significant difference in anemia or thrombocytopenia among the different age groups. Anemia and thrombocytopenia were more prevalent in older patients receiving an anthracycline or platinum-containing regimen. In multivariate analysis, lower risk of SN or FN remained significantly associated with increasing age (P=.044) after adjustment for stage (P=.115) and actual RDI (P=.066). Prophylactic colony-stimulating factor was used in 5% of patients with no significant difference observed among the age groups. Conclusion: This report represents one of the largest studies to date of elderly cancer patients receiving chemotherapy. Neutropenic events increased with actual RDI while decreasing with age and disease stage. Advancing age alone does not appear to increase the risk of hematologic toxicity in older patients receiving full dose intensity chemotherapy. Nevertheless, half of elderly patients in this study received major reductions in actual dose intensity. More information is needed on the impact of reduced dose intensity chemotherapy on long term clinical outcomes in this population.
24
Schulte, Johannes H., Lucas Moreno, David Simon Ziegler, et al. "Final analysis of phase I study of ceritinib in pediatric patients with malignancies harboring activated anaplastic lymphoma kinase (ALK)." Journal of Clinical Oncology 38, no. 15_suppl (2020): 10505. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.10505.
Full textAbstract:
10505 Background: Activation of anaplastic lymphoma kinase has been detected in several pediatric malignancies, including anaplastic large-cell lymphoma (ALCL), inflammatory myofibroblastic tumor (IMT), neuroblastoma and others. Preliminary findings from this phase 1, multicenter, dose-escalation study (NCT01742286) indicated a Maximum Tolerated Dose (MTD)/Recommended Dose for Expansion (RDE) of the potent oral ALK inhibitor ceritinib to be 510 mg/m2 (fasted) and 500 mg/m2 (fed) in pediatric patients (pts). Here, we report final safety, pharmacokinetics (PK) and efficacy results. Methods: Children aged ≥1 to <18 years with advanced, mostly pretreated, ALK-aberrant malignancies were enrolled in this study. Dose escalation was conducted to determine the MTD/RDE of ceritinib (primary objective), in both fasted and fed states, following which pts entered an expansion phase to evaluate safety, tolerability, and efficacy at the MTD/RDE. Secondary objectives were evaluation of safety, PK, and efficacy (overall response rate [ORR], duration of response [DOR] and progression-free survival [PFS]). Results: A total of 83 pts (median age, 8 years) with ALK-aberrant malignancies were enrolled into dose-escalation (n = 40) and expansion (n = 43) study periods. Of these, 55 pts (neuroblastoma, n = 30; IMT, n = 10; ALCL, n = 8; others, n = 7) were treated with ceritinib at MTD/RDE (510 mg/m2 [fasted], n = 13; 500 mg/m2 [fed], n = 42). Systemic exposure of ceritinib between the two doses was comparable, so data were pooled for efficacy assessment. The ORRs (95% CI) were 75% (34.9-96.8) for pts with ALCL, 70% (34.8-93.3) for IMT and 20% (7.7-38.6) for neuroblastoma. The median DOR was 15 months (95% CI: 5.8, 22.2) for the 6/30 pts with neuroblastoma who had confirmed CR or PR treated at fasted/fed MTD/RDE. Median DOR was not reached for those with ALCL and IMT. Most common adverse events (AEs) (N = 83; all-grades, all-causality, ≥50% of pts): vomiting (86.7%), diarrhea (78.3%), increased ALT (65.1%), increased AST (59.0%), nausea (56.6%), and abdominal pain (50.6%). Grade 3/4 AEs were observed in 80.7% of pts (mostly transaminase elevations) and were manageable. Six pts (7.2%) were discontinued from ceritinib due to a grade 3/4 AE (mostly transaminase elevation). Conclusions: Substantial activity was observed with ceritinib at the RDE in pts with IMT, ALCL and heavily pretreated neuroblastoma. The toxicity profile of ceritinib in children was manageable and similar to that previously reported in adults. Clinical trial information: NCT01742286.
25
Vause, Sophie. "Différences de genre en matière de mobilité professionnelle des migrants congolais (RDC) en Belgique." Espace populations sociétés, no. 2011/2 (September 1, 2011): 195–213. http://dx.doi.org/10.4000/eps.5160.
Full text
26
Chhetri, Binoy, and A. C. Sinha. "Moisture Conservation and Nutrient Management Practices on Growth and Yield of Maize (Zea Mays L.)." Current Agriculture Research Journal 7, no. 3 (2019): 390–407. http://dx.doi.org/10.12944/carj.7.3.15.
Full textAbstract:
Plant nutrients and soil moisture are considered some of the most important factors affecting physiological characters and grain yield of maize. Therefore, a field experiment was conducted at UBKV, Cooch Behar, West Bengal during 2013 and 2014 to study the effects of moisture conservation and nutrient management practices on growth and yield of maize (Zea mays L.). The experiment was laid out in a split –plot design with three replications. Four levels of moisture conservation practices M0: without irrigation and without mulch, M1: irrigation as and when required, M2: dry weed biomass mulch @5.0t ha-1 M3: FYM mulch @ 5.0 t ha-1 were assigned to main plots and four levels of nutrient management N1: 100% RDF 80:40:40 kg ha-1 of N:P2O5: K2O N2:100% RDF + phosphate solubilising bacteria (PSB) + Azotobacter N3:75% RDF+ PSB + Azotobacter + vermicompost (VC) @ 5.0 t ha-1 and N4:50% RDF + PSB + Azotobacter + 50% vermicompost @ 2.5t ha-1 for sub plot. Among the moisture conservation practices, application of irrigation recorded the highest growth, yield attributes, yield and harvest index followed by FYM mulch and dry weed bio-mass mulch. Similarly, N, P and K uptake of maize was recorded highest under irrigation followed by FYM mulch; dry weed bio mass mulch and lowest N, P and K uptake were recorded under without irrigation and mulch. Among the nutrient management practices the highest growth, yield attributes, yield, harvest index and N, P & K uptake were recorded under 75% RDF + PSB + Azotobacter + vermicompost @ 5.0 t ha-1 followed by 100% RDF + PSB+ Azotobacter & 100% RDF and lowest were recorded under 50% RDF + PSB + Azotobacter + 50% vermicompost 2.5 t ha-1 . Likewise, maximum benefits were recorded under 75% RDF + PSB+ Azotobacter + vermicompost @ 5.0 t ha-1 and lowest net return and return per rupee invested were recorded under 50% RDF + PSB + Azotobacter + 50% vermicompost 2.5 t ha-1. From this study, maize grown with irrigation and supplied with 75% RDF + PSB + Azotobacter + vermicompost @ 5.0 t ha-1 is found the best for obtaining overall gain on a sustainable basis.
27
Li, Yu Pin, Ming Pei You, Timothy D. Colmer, and Martin J. Barbetti. "Effect of Timing and Duration of Soil Saturation on Soilborne Pythium Diseases of Common Bean (Phaseolus vulgaris)." Plant Disease 99, no. 1 (2015): 112–18. http://dx.doi.org/10.1094/pdis-09-13-0964-re.
Full textAbstract:
Understanding combined abiotic (waterlogging) and biotic (Pythium spp.) stress resistance remains an important challenge to improving common bean (Phaseolus vulgaris) productivity in disease-prone regions with irregular but intensive rainfall patterns. This study documented the effects of timing (1, 3, 5, 7, and 9 days after sowing) and duration (3, 6, 12, and 24 h) of soil saturation (waterlogging) on damping-off, as well as hypocotyl and root diseases of common bean caused by Pythium irregulare. There were significant effects of timing of waterlogging as well as the presence or absence of the pathogen on emergence of the three bean varieties tested; namely, ‘Gourmet Delight’, ‘Brown Beauty’, and ‘Pioneer’. The interaction between time of waterlogging and variety was significant for both root and hypocotyl disease severities. In the presence of P. irregulare, waterlogging 1 day after sowing resulted in the least emergence (55.2 ± 5.6%), although plants that survived after 5 weeks had less hypocotyl and root disease (percent hypocotyl disease index [%HDI] ± standard deviation [SD] = 42.0 ± 2.1% and percent root disease index [%RDI] ± SD = 42.4 ± 2.1%, respectively) than nonwaterlogged plants (%HDI = 50.8 ± 2.1% and %RDI = 48.0 ± 2.1%, respectively). The most severe disease assessed 5 weeks after sowing occurred when plants were subjected to waterlogging 9 days after sowing (%HDI = 61.3 ± 2.1% and %RDI = 56.0 ± 2.1%). In general, both hypocotyl and root disease severity increased as the duration of waterlogging increased from 1 to 24 h, with %HDI increasing from 53.9 ± 3.2% to 70.9 ± 3.2%, while %RDI increased from 57.2 ± 1.5% to 73.7 ± 1.5%. Varieties responded differentially in terms of disease development after waterlogging, with the least hypocotyl and root disease on Gourmet Delight (%HDI = 51.4 ± 3.2 and %RDI = 60.1 ± 1.5, respectively) and greatest on Pioneer (%HDI = 66.2 ± 3.2 and %RDI = 64.9 ± 1.5, respectively). Despite being susceptible to hypocotyl and root disease, Pioneer had the greatest emergence and shoot dry weight overall among the three varieties, suggesting that this variety has a degree of tolerance to waterlogging, P. irregulare infection, and the combination of these two stresses. Although the resistance of Gourmet Delight could be exploited to breed bean varieties that exhibit less hypocotyl and root disease when waterlogging occurs, the tolerance to both P. irregulare infection and waterlogging observed for Pioneer could also be exploited to breed varieties that incur less damage from hypocotyl or root disease or waterlogging. Furthermore, this study demonstrated what appears to be independent resistance to hypocotyl versus root infection by P. irregulare, which offers an opportunity to combine resistance to both stresses to reduce the impact of damping-off and root rot in conditions conducive for P. irregulare.
28
Argelès, Daniel. "La confrontation littéraire au passé national-socialiste dans le contexte de la RDA des années 1960." Germanica, no. 42 (June 1, 2008): 119–41. http://dx.doi.org/10.4000/germanica.520.
Full text
29
Mehdi, Miqdad, Muhammad Hamid Siddiqi, Liu Xiaomin, and Tayyab Qureshi. "Study of Hyrothermally RDF Samples for Energy Applications: Thermogravimetric Analysis." IOP Conference Series: Earth and Environmental Science 565 (October 1, 2020): 012096. http://dx.doi.org/10.1088/1755-1315/565/1/012096.
Full text
30
Chang, Rita Yuk-Kwan, Brian Hung-Hin Lang, Ai Chen Chan, and Kai Pun Wong. "Evaluating the Efficacy of Primary Treatment for Graves’ Disease Complicated by Thyrotoxic Periodic Paralysis." International Journal of Endocrinology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/949068.
Full textAbstract:
Objective. Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of Graves’ disease (GD). The present study compared the long-term efficacy of antithyroid drugs (ATD), radioactive iodine (RAI), and surgery in GD/TPP.Methods. Sixteen patients with GD/TPP were followed over a 14-year period. ATD was generally prescribed upfront for 12–18 months before RAI or surgery was considered. Outcomes such as thyrotoxic or TPP relapses were compared between the three modalities.Results. Eight (50.0%) patients had ATD alone, 4 (25.0%) had RAI, and 4 (25.0%) had surgery as primary treatment. Despite being able to withdraw ATD in all 8 patients for 37.5 (22–247) months, all subsequently developed thyrotoxic relapses and 4 (50.0%) had ≥1 TPP relapses. Of the four patients who had RAI, two (50%) developed thyrotoxic relapse after 12 and 29 months, respectively, and two (50.0%) became hypothyroid. The median required RAI dose to render hypothyroidism was 550 (350–700) MBq. Of the 4 patients who underwent surgery, none developed relapses but all became hypothyroid.Conclusion. To minimize future relapses, more definitive primary treatment such as RAI or surgery is preferred over ATD alone. If RAI is chosen over surgery, a higher dose (>550 MBq) is recommended.
31
Yang, Fei Hua, Qiang Zhang, Chun Ping Li, and Jia Yu Zhan. "Gasification Characteristics of MSW RDF." Advanced Materials Research 781-784 (September 2013): 2174–78. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.2174.
Full textAbstract:
A series of gasification experiments of MSW RDF was made by using independently developed gasification device. When MSW RDF gasified at 200°C ~900°C, the trend of instantaneous gas production was increased, decreased, then increased rapidly after downward, 2 peak of instantaneous gas production were 500°C and 800 °C. When the gasification temperature is below 400 °C, except for CO, the content of various combustible gases are rarely. With the increase of the gasification temperature, bottom ash content decreased, but tar yield and volume percentage content and calorific value of the combustible gas increased gradually. when the gasification temperature reached 900°C, the calorific value of combustible gas reaches the highest, 28MJ/m3, bottom ash reaches the lowest, only 12%. Tar reached the highest value at 600 °C ~700 °C, about 40%.
32
Sanchez, Gabriel M., Jon M. Erlandson, Brendan J. Culleton, Douglas J. Kennett, and Torben C. Rick. "High-Resolution AMS14C Dates for the Par-Tee Site (35CLT20) and Prehistoric Whale Hunting on the Oregon Coast." Radiocarbon 58, no. 2 (2016): 397–405. http://dx.doi.org/10.1017/rdc.2016.10.
Full textAbstract:
AbstractEvidence for aboriginal whale hunting, long thought to be a practice limited to Northwest Coast tribes in northern Washington and British Columbia’s Vancouver Island, was previously reported at the Par-Tee site on the Oregon coast between about cal AD 620 and 990. An age estimate for a humpback whale phalanx with an embedded elk bone harpoon point was based on radiocarbon dates on charcoal not directly associated with the whale bone. We present high-resolution accelerator mass spectrometry (AMS)14C dates for purified bone collagen extracted directly from the whale phalanx and embedded harpoon point. A calibrated date for the harpoon point places the whale hunting event between about cal AD 430 and 550. The apparent14C age of the whale bone is estimated to be 220±3714C yr older than the marine model age at that time, consistent with values from the eastern Pacific. These new dates suggest that whale hunting took place on the Oregon coast as much as 200–500 yr earlier than previously reported and more than a millennium before historic contact in the region. Our research highlights the significance of museum collections and high-resolution AMS14C dating for addressing a variety of issues related to ancient archaeological sites and cultures.
33
Lyman, Gary H., Jeffrey Crawford, David C. Dale, Sadie Whittaker, and Dianne Tomita. "Changing Patterns of Chemotherapy Delivery and Supportive Care for Aggressive B-Cell Non-Hodgkin's Lymphoma." Blood 118, no. 21 (2011): 2670. http://dx.doi.org/10.1182/blood.v118.21.2670.2670.
Full textAbstract:
Abstract Abstract 2670 Background: For several decades, non-Hodgkin's Lymphoma (NHL) has been treated with a CHOP-based chemotherapy regimen with curative intent. In 2004, a large retrospective analysis of patients with aggressive NHL treated at 567 community practices from 1999 to 2001 indicated that only 52% of patients received chemotherapy at a relative dose intensity (RDI) ≥ 85% (Lyman GH, et al. JCO. 2004;22:4302–11). This study showed that primary prophylactic use of colony-stimulating factors (CSF) starting with the first cycle of chemotherapy was associated with a reduced incidence of febrile neutropenia (FN) and was an independent predictor of RDI ≥ 85%. At that time, only about 12% of patients received CSF in the first cycle. To evaluate changes in oncology practice, we reviewed recent treatment patterns, including RDI for delivered chemotherapy and CSF support, for patients with aggressive B-cell NHL at 36 community-based oncology practices and hospitals, the majority of which participated in the previous study. Methods: Patient charts and electronic medical records from January 2006 to December 2009 were reviewed. Patients were included if they had aggressive B-cell NHL, were ≥ 18 years old, and completed ≥ 1 cycle of chemotherapy with the following standard cytotoxic regimens during the chart abstraction period: cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP); CHOP-rituximab (CHOP-R); or cyclophosphamide, mitoxantrone, vincristine, and prednisone (CNOP). Exclusion criteria included prior stem-cell transplantation, prior/concurrent radiotherapy, and chemotherapy started outside of the chart abstraction period. The primary endpoint was delivered RDI, based on the proportion of chemotherapy actually delivered compared to published standards, as in the previous study. Other endpoints included chemotherapy dose delays and reductions, grade 3/4 neutropenia, grade 3/4 FN, FN-related hospitalization, CSF use, and antimicrobial use. Results: Records of 500 patients were reviewed. Mean patient age was 63.7 years (range: 18–90), and 55% of patients were male. The majority (90.8%) received CHOP-R chemotherapy on a 21-day schedule (CHOP-R 21) for a mean of 5.5 cycles (range: 1–8). The mean RDI delivered for CHOP-21 ± R was 87.6%. Delivered chemotherapy intensity in the current study was considerably greater than that observed in the previous study with an increase in delivered RDI ≥ 85% (current vs previously published: 71% vs 52%) and a decrease in dose reductions (20.6% vs 35%). Dose delays appear similar between the studies (26.4% vs 23%). In the current study, 67% of patients had grade 3/4 neutropenia, compared to 62% of patients in the previous study. In addition, the incidence of clinical FN (12% vs 20.9%) and the number of patients hospitalized for FN (9.6% vs 15.9%) has decreased. Use of primary prophylactic CSF has increased (75% vs 12%) with a shift from support with filgrastim to pegfilgrastim. Filgrastim was the predominant CSF in the previous study while, in the current study, 78.6% of patients received pegfilgrastim only, and 9.2% of patients received pegfilgrastim and filgrastim. While antimicrobial use was not reported in the previous study, in the current study, 51% of patients received at least one antimicrobial; 13% received prophylactic antimicrobials, and 45.8% received therapeutic antimicrobials. Conclusions: Patterns of chemotherapy delivery and supportive care have changed markedly for the management of patients with aggressive B-cell NHL. In the United States, CHOP-R 21 is now the most commonly used regimen, as compared to CHOP-21 in the previous study. Average RDI delivered and prophylactic use of CSF, predominantly pegfilgrastim, have increased, while dose reductions, FN, and FN-related hospitalizations have decreased. However, dose delays and reductions are still relatively common, suggesting opportunities for further improvements in the treatment of patients with aggressive B-cell NHL. Disclosures: Lyman: Amgen: Research Funding. Crawford:Amgen: Consultancy, Honoraria, Research Funding. Dale:Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Whittaker:Amgen: Employment. Tomita:Amgen: Employment, Equity Ownership.
34
Krus, Anthony M., Anne M. Jensen, W. Derek Hamilton та Kerry Sayle. "A Context-Appropriate Approach to Marine 14C Calibration: Δr and Bayesian Framework for the Nuvuk Cemetery, Point Barrow, Alaska". Radiocarbon 61, № 03 (2019): 733–47. http://dx.doi.org/10.1017/rdc.2019.20.
Full textAbstract:
ABSTRACTThis study provides an assessment of the temporal changes in ΔR, which is the local deviation from the global surface water marine reservoir effect (MRE), in the Point Barrow area of the Alaskan Arctic, a coastal archaeological area that has experienced severe erosion accelerated by global warming. A total of 26 samples were submitted for radiocarbon (14C) dating from eight secure Thule (AD 1000–1750) archaeological contexts, and specifically from archaeological features with paired processed seal and caribou bones that had been frozenin situ. This new approach towards ΔR estimation provides a best-fit local correction for the14C dating of human populations by focusing on the marine mammal (seals) predominantly consumed by the Thule (Coltrain et al. 2016). The weighted-mean ΔR value on these pairs is 450 ± 84 yr, which is about 50 years less than the weighted-mean (506 ± 69 yr) for the Point Barrow area calculated through14C measurements from four known-age bivalves collected in AD 1913 (McNeely et al. 2006). The effects of using this new ΔR value for calibration was assessed through the Bayesian chronological modeling of 5414C measurements from samples of human skeletons interred in the Nuvuk cemetery at Point Barrow, the largest ancient cemetery in northwest Alaska and traditionally thought to date to the Thule and earlier Birnirk (AD 500–1000) periods.
35
Buitrón-Bustamante, Johanna Liseth. "Estandarización de un método de detección molecular del Cucumber mosaic virus (cmv) en banano ecuatoriano." Corpoica Ciencia y Tecnología Agropecuaria 18, no. 1 (2016): 113. http://dx.doi.org/10.21930/rcta.vol18_num1_art:562.
Full textAbstract:
<p>El cultivo del banano en el Ecuador se ve afectado por una serie de enfermedades, de las cuales el Cucumber mosaic virus (cmv) es uno de los fitopatógenos más importantes. Con este estudio se buscó estandarizar una técnica molecular para la detección sensible y altamente específica de este agente viral en el banano ecuatoriano. Para este fin, se realizó el diseño de primers específicos, a partir de la secuencia que se codifica para la proteína de la cápside del virus. Los primers PC-F1, PC-RD1 y K-F, usados en cDNA replicado a partir de ARN de banano infectado, permitieron detectar eficientemente la presencia del virus con la aplicación de reacciones de retrotranscripción y hemi-nested PCR. Se reportó la detección del virus incluso en plantas asintomáticas, lo cual evidencia que esta técnica resulta de alta sensibilidad para su aplicación en diagnósticos rutinarios del sector bananero.</p>
36
Chandon, Jean-Louis. "Liens humains et liens financiers parmi les 500 premières sociétés exerçant leur activité en France." Revue d’économie industrielle 47, no. 1 (1989): 53–65. http://dx.doi.org/10.3406/rei.1989.1284.
Full text
37
De, B., and AC Sinha. "Oil and protein yield of rapeseed (Brassica campestris L.) as influenced by integrated nutrient management." SAARC Journal of Agriculture 10, no. 2 (2014): 41–49. http://dx.doi.org/10.3329/sja.v10i2.18322.
Full textAbstract:
A field experiment was conducted during 2007-2009 in the instructional farm of Uttar Banga Krishi Viswavidyalaya, West Bengal, India to find out the effect of integrated nutrient management on oil and protein yield of Rapeseed (Brassica campestris var. Yellow sarson). The experiment was laid out in randomized block design with 12 treatments viz., 100% Recommended Dose Fertilizer (RDF) 60:30:30 Kg ha-1 of N: P: K (T1), 100% RDF + Borax @ 10.0 Kg ha-1 (T2), FYM @ 10.0 t ha-1 (T3), Vermicompost @ 5.0 t ha-1 (T4), Neemcake @ 5.0 t ha-1 (T5), Poultry manure @ 5.0 t ha-1 (T6), T1+ FYM @ 5.0 t ha-1 (T7), T1+ Vermicompost (VC) @ 2.5 t ha-1 (T8), T1+ Neemcake (NC) @ 2.5 t ha-1 (T9), T1+ Poultry Manure (PM) @ 2.5 t ha-1 (T10), 50% RDF+ FYM @ 2.5 t ha-1 + VC @1.25 t ha-1 + NC @ 1.25 t ha-1 + PM @ 1.25 t ha-1 (T11) and Control (T12) and replicated thrice. Average results of oil and protein content and their respective yields was maximum (44.99 & 29.84% and 606.33 & 402.11 kg ha-1 respectively) in the crop fertilized with 50% RDF + FYM @ 2.5 t ha-1 + VC @1.25 t ha-1 + NC @ 1.25 t ha-1 + PM @ 1.25 t ha-1 (T11) followed by T9 i.e. application of T1+ Neemcake @ 2.5 t ha-1 (44.81 & 29.22% and 600.67 & 391.50 kg ha-1 respectively) and T8 i.e. application of T1+ Vermicompost @ 2.5 t ha-1 (44.24 & 29.01 and 585.33 & 383.67 kg ha-1 respectively). Based on pooled data T11 treatment recorded maximum seed yield of 1347.68 kg ha-1 which was statistically at par with T9 (1340.47 kg ha-1), However, treatment T1 (100 % RDF) showed highest BCR (3.85) due to low cost of cultivation. DOI: http://dx.doi.org/10.3329/sja.v10i2.18322 SAARC J. Agri., 10(2): 41-49 (2012)
38
Sarpong, Emmanuel, Damon Smith, Rudra Pokhrel, Marc N. Fiddler, and Solomon Bililign. "Refractive Indices of Biomass Burning Aerosols Obtained from African Biomass Fuels Using RDG Approximation." Atmosphere 11, no. 1 (2020): 62. http://dx.doi.org/10.3390/atmos11010062.
Full textAbstract:
Biomass burning (BB) aerosols contribute to climate forcing, but much is still unknown about the extent of this forcing, owing partially to the high level of uncertainty regarding BB aerosol optical properties. A key optical parameter is the refractive index (RI), which influences the absorbing and scattering properties of aerosols. This quantity is not measured directly, but it is obtained by fitting the measured scattering cross section and extinction cross section to a theoretical model using the RI as a fitting parameter. We used the Rayleigh–Debye–Gans (RDG) approximation to retrieve the complex RI of freshly emitted BB aerosol from two fuels (eucalyptus and olive) from Africa in the spectral range of 500–580 nm. Experimental measurements were carried out using cavity ring-down spectroscopy to measure extinction over the range of wavelengths of 500–580 nm and nephelometry to measure scattering at three wavelengths of 450, 550, and 700 nm for size-selected BB aerosol particles. The fuels were combusted in a tube furnace at a temperature of 800 °C, which is representative of the flaming stage of burning. Filter samples were collected and imaged using tunneling electron microscopy to obtain information on the morphology and size of the particles, which was used in the RDG calculations. The mean radii of the monomers were 27.8 and 31.5 nm for the eucalyptus and the olive fuels, respectively. The components of the retrieved complex RI were in the range of 1.31 ≤ n ≤ 1.56 and 0.045 ≤ k ≤ 0.468. The real and complex parts of the RI increase with increasing particle mobility diameter. The real part of the RI is lower, and the imaginary part is higher than what was recommended in literature for black carbon generated by propane or field measurements from fires of mixed wood samples. Fuel dependent results from controlled laboratory experiments can be used in climate modeling efforts and to constrain field measurements from biomass burning.
39
Singh, M. P. "Book Review: Vinod Rai, Not Just an Accountant: The Diary of the Nation’s Conscience Keeper." Indian Journal of Public Administration 64, no. 4 (2018): 749–50. http://dx.doi.org/10.1177/0019556118788424.
Full text
40
Syguła, Ewa, Kacper Świechowski, Paweł Stępień, Jacek A. Koziel, and Andrzej Białowiec. "The Prediction of Calorific Value of Carbonized Solid Fuel Produced from Refuse-Derived Fuel in the Low-Temperature Pyrolysis in CO2." Materials 14, no. 1 (2020): 49. http://dx.doi.org/10.3390/ma14010049.
Full textAbstract:
The decrease in the calorific value of refuse-derived fuel (RDF) is an unintended outcome of the progress made toward more sustainable waste management. Plastics and paper separation and recycling leads to the overall decrease in waste’s calorific value, further limiting its applicability for thermal treatment. Pyrolysis has been proposed to densify energy in RDF and generate carbonized solid fuel (CSF). The challenge is that the feedstock composition of RDF is variable and site-specific. Therefore, the optimal pyrolysis conditions have to be established every time, depending on feedstock composition. In this research, we developed a model to predict the higher heating value (HHV) of the RDF composed of eight morphological refuse groups after low-temperature pyrolysis in CO2 (300–500 °C and 60 min) into CSF. The model considers cardboard, fabric, kitchen waste, paper, plastic, rubber, PAP/AL/PE (paper/aluminum/polyethylene) composite packaging pack, and wood, pyrolysis temperature, and residence time. The determination coefficients (R2) and Akaike information criteria were used for selecting the best model among four mathematical functions: (I) linear, (II) second-order polynomial, (III) factorial regression, and (IV) quadratic regression. For each RDF waste component, among these four models, the one best fitted to the experimental data was chosen; then, these models were integrated into the general model that predicts the HHV of CSF from the blends of RDF. The general model was validated experimentally by the application to the RDF blends. The validation revealed that the model explains 70–75% CSF HHV data variability. The results show that the optimal pyrolysis conditions depend on the most abundant waste in the waste mixture. High-quality CSF can be obtained from wastes such as paper, carton, plastic, and rubber when processed at relatively low temperatures (300 °C), whereas wastes such as fabrics and wood require higher temperatures (500 °C). The developed model showed that it is possible to achieve the CSF with the highest HHV value by optimizing the pyrolysis of RDF with the process temperature, residence time, and feedstock blends pretreatment.
41
Pramanick, Biswajit, Koushik Brahmachari, Arup Ghosh, and ST Zodape. "Effect of seaweed saps on growth and yield improvement of transplanted rice in old alluvial soil of West Bengal." Bangladesh Journal of Botany 43, no. 1 (2014): 53–58. http://dx.doi.org/10.3329/bjb.v43i1.19746.
Full textAbstract:
On summer rice, foliar spray was applied thrice at different concentrations (0, 2.5, 5.0, 7.5, 10.0 and 15.0%, v/v) of seaweed extracts (namely, Kappaphycus sp. and Gracilaria sp.) along with the recommended dose of fertilizer (RDF). The highest grain yield was recorded with the applications of 15% Kappaphykus sap + RDF, followed by 15% Gracilaria sap + RDF extract resulting in 41.47 and 34.99% increases, respectively compared to the control. The maximum straw yield was also achieved with 15% seaweed extract application. Improved nutrient uptake (N, P and K) was also observed with seaweed extract applications. DOI: http://dx.doi.org/10.3329/bjb.v43i1.19746 Bangladesh J. Bot. 43(1): 53-58, 2014 (June)
42
Das, Samir, Suresh Chandra Das, and Rishendra Verma. "Occurrence of RD9 Region and 500 bp Fragment among Clinical Isolates ofMycobacterium tuberculosisandMycobacterium bovis." Microbiology and Immunology 51, no. 2 (2007): 231–34. http://dx.doi.org/10.1111/j.1348-0421.2007.tb03905.x.
Full text
43
Ahn, B. C., S. Y. Jeong, S. W. Lee, J. Lee, and C. M. Hong. "Distant metastatic lesions in patients with differentiated thyroid carcinoma." Nuklearmedizin 52, no. 04 (2013): 121–29. http://dx.doi.org/10.3413/nukmed-0541-12-11.
Full textAbstract:
Summary Aim: Many investigators have reported an inverse relationship between iodine and glucose utilization of differentiated thyroid carcinoma (DTC) according to its degree of differentiation; however, not every DTC is compatible with this phenomenon. This study was conducted to evaluate the clinical implication of iodine and glucose uptake at distant metastatic lesions in DTC patients. Patients, methods: 64 DTC patients (women 47; mean age 49.9 ± 16.4 years) with distant metastasis who underwent post 131I treatment whole-body scan (RxWBS) and FDG PET/CT were included in the study. Radioiodine (RAI) and FDG uptake of metastatic lesions were evaluated. TSH stimulated serum thyroglobulin (s-Tg) were obtained. Results: 53 of 64 patients (82.8%) were RAI(+) group, and 37 patients (57.8%) were FDG(+) group. Patients in the RAI(–) group showed a higher rate of FDG uptake than RAI(+) group (100.0% vs. 49.1%, p = 0.002). Patients in the FDG(–) group showed a higher rate of RAI uptake than FDG(+) group (100.0% vs. 70.3%, p = 0.002). Patients with s-Tg < 100 ng/ml were frequently observed in the FDG(–)/RAI(+) group and the FDG(+)/ RAI(–) group (p = 0.023). And patients with s-Tg ≥ 500 ng/ml were more frequently observed in the FDG(+)/RAI(+) group, compared with the FDG(+)/RAI(–) group (p = 0.036). Reduced disease-specific survival (DSS) was observed in patients with RAI(–) (p = 0.003), FDG(+) (p = 0.006), SUVmax > 3.6 (p<0.001), and s-Tg > 75.8 ng/ml (p = 0.009). In multivariate analysis, only a SUVmax > 3.6 was significantly predictive of DSS (p = 0.006). Conclusion: An inverse relationship between RAI and FDG uptake, flip-flop phenomenon, was observed in patients with metastatic lesions of DTC. Reduced disease-specific survival was observed in patients with FDG(+), RAI(–) in metastatic lesions, or high s-Tg value.
44
Irianto, Ignatius Djoko, Sukmanto Dibyo, Sriyono Sriyono, Djati H. Salimy, Rahayu Kusumastuti, and Marliyadi Pancoko. "PERFORMANCE ANALYSIS OF RDE ENERGY CONVERSION SYSTEM IN VARIOUS REACTOR POWER CONDITION." JURNAL TEKNOLOGI REAKTOR NUKLIR TRI DASA MEGA 21, no. 3 (2019): 99. http://dx.doi.org/10.17146/tdm.2019.21.3.5570.
Full textAbstract:
Reaktor Daya Eksperimental (RDE) is an experimental power reactor based on High Temperature Gas-cooled Reactor (HTGR) technology with thermal power of 10 MW. As an experimental power reactor, RDE is designed for electricity generation and provides thermal energy for experimental purposes. RDE energy conversion system is designed with cogeneration configuration in the Rankine cycle. To ensure the effectiveness of its cogeneration, the outlet temperature of the RDE is set at 700°C and steam generator outlet temperature is around 530°C. Analysis of the performance of the energy conversion system in various power levels is needed to determine the RDE operating conditions. This research is aimed to study the performance characteristics of RDE energy conversion systems in various reactor power conditions. The analysis was carried out by simulating thermodynamic parameter calculations on the RDE energy conversion system and the overall cooling system using the ChemCad program package. The simulation is carried out by increasing the reactor power from 0 MW to 10 MW at constant pressure and constant mass flow rate. The simulation results show that the steam fraction at the steam generator outlet increases starting from 3 MW reactor power and reaches saturated steam after the thermal power level of 7.5 MW. From the results, it can be concluded that with constant mass flow rate and operating pressure, optimal turbine power is obtained after the reactor thermal power reached 7.5 MW.Keywords: RDE, Energy Conversion System, Performance, Reactor Power, ChemCad
45
Pal, Ashok, Sanjay Kumar Dwivedi, Pradip Kumar Maurya, and Poolchand Kanwar. "Effect of seaweed saps on growth, yield, nutrient uptake and economic improvement of maize (sweet corn)." Journal of Applied and Natural Science 7, no. 2 (2015): 970–75. http://dx.doi.org/10.31018/jans.v7i2.716.
Full textAbstract:
A field experiment was conducted during the rabi season of 2012-13 at Research cum Instructional Farm of Indira Gandhi Krishi Vishwavidyalaya, Raipur (Chhattisgarh) to study the effects of seaweed saps on growth, yield, nutrient uptake and economic of maize (sweet corn) in Matasi soil of Chhattisgarh. The foliar spray of two different species (namely Kappaphycus and Gracilaria) was applied thrice at different interval of crop with different concentrations (0, 2.5, 5.0, 7.5, 10.0 and 15% v/v) of seaweed extracts. Foliar applications of seaweed extract significantly enhanced the growth, yield, nutrient uptake and B:C ratio parameters. The green cob yield (189.97 q ha-1) and fodder yield (345.19 q ha-1) were recorded highest under treatment (T8) 15% G Sap + recommended dose of fertilizer (RDF) which was significant similar with treatment 15% K Sap + RDF (185.24 q ha-1) in case of green cob yield. The highest N, P and K uptake by green cob and fodder were observed under 15% G Sap + RDF (T8). Treatment 15% G Sap + RDF (T8), recorded maximum gross return (Rs. 2,07,230 ha-1), net return (Rs. 1,38,756 ha-1) and B:C ratio (2.0), which was followed by treatment 15% K Sap + RDF (T4) with net return (Rs. 1,33,199 ha-1) and B:C ratio (1.95). Treatment 15% G Sap + RDF (T8) gave Rs. 45,996 ha-1 more as compared to Water spray + RDF (T9).
46
Hampel, Christian. "Energieregulierung – Neues aus Gesetzgebung und (Behörden-) Praxis I/2018." Recht der Energiewirtschaft 18, no. 4-5 (2018): 223–27. http://dx.doi.org/10.1515/rde-2018-184-510.
Full text
47
Bhavani, V., and N. Prabhavathy Devi. "Assessment of Macro Nutrients and Micro Nutrients Intake of Collage Age Population: A Population Based Study." Shanlax International Journal of Arts, Science and Humanities 7, no. 3 (2020): 97–103. http://dx.doi.org/10.34293/sijash.v7i3.956.
Full textAbstract:
Background: In present India, due to increased urbanization and various other factors, there is a drastic change in the dietary patterns of college students and young adults. Maintaining the right eating habits of college student means a lot for the prevention of many diseases that could occur in adult period. Aim: To evaluate the Macro and micro nutrients intake of the college population of Chennai Methods and Tools: Using Random sampling techniques, 1000 (500 male and 500 female) college students were selected and data regarding food frequency intake was evaluated. Nutrient intake is assessed by means of three-day dietary record. The food consumed for three consecutive days were recorded by the subjects. Food intake data were converted into raw amounts in terms of food groups and in turn were translated into energy, protein, fat, carbohydrate, and fiber using food composition tables. The nutrient intakes of the subjects were computed against Recommended Dietary Allowance (RDA) for ensuring the appropriateness of intake derived based on RDA. The data were tabulated and subjected to appropriate statistical analysis. Results: Consumption of Macro nutrient intake and micro nutrients were found to be more among male than female. Only vitamin C intake found to be more among female than male. It is clear that both male and female did not meet the requirements of RDA. Fat intake was more than the RDA for both male and female participants. Conclusion: Our study concludes that Macro and micro nutrient deficiency is prevalent among our study population, irrespective of the gender, whereas fat intake is more than the RDA which is leading cause for obesity and other non-communicable diseases. Thus it is essential to educate the students to consume nutrient densed food and reduce the intake of energy densed food.
48
Liu, Gang, Hua Min Zhang, and Yuan Wei Ma. "Pt4ZrO2/C Cathode Catalyst with Excellent Durability for High Temperature PEMFC Based on H3PO4 Doped PBI." Materials Science Forum 561-565 (October 2007): 1589–92. http://dx.doi.org/10.4028/www.scientific.net/msf.561-565.1589.
Full textAbstract:
Pt4ZrO2/C was prepared and compared with commercial Pt/C (46.6 wt.% TKK) in terms of the durability as cathode catalyst in a high temperature proton exchange membrane fuel cell (PEMFC) based on H3PO4 doped polybenzimidazole (PBI) by a potential sweep test. The catalysts before and after the potential sweep test were characterized by RDE, XRD, TEM and ICP-AES. After 3000 cycles potential sweep test, the overall performance loss of the Pt4ZrO2/C membrane electrode assembly (MEA) was less than that of the Pt/C MEA. In brief, the preliminary results indicate that Pt4ZrO2/C catalyst is a good candidate of Pt/C catalyst in high temperature PEMFC based on H3PO4 doped PBI for achieving longer cell life-time and higher cell performance.
49
Topal, A., I. Holenko, and M. Yurchenko. "THE USE OF EXPERIENCE OF COAL COMBUSTION IN A CIRCULATING FLUIDIZED BED FOR DESIGNING OF MEDIUM CAPACITY STEAM BOILERS FOR BURNING OF WET WASTE OF COAL PREPARATION AND RDF IN UKRAINE." Energy Technologies & Resource Saving, no. 4 (December 20, 2020): 20–29. http://dx.doi.org/10.33070/etars.4.2020.02.
Full textAbstract:
The necessity to implement advanced combustion technologies to utilize MSW/SRF/RDF and coal reject waste is an important problem for Ukraine to be solved. The introduction of such technologies will favor to involve annually about 2 mln t of RDF and partly cover deficit of bituminous coal, lack of which is currently faced. The technological niche for CFB combustion of RDF/SRF has certain optimal range bearing in mind technological, ecological (2010/75/EU Directive etc.) and financial performance. In view of this it seems reasonable to implement CFB for RDF/SRF firing starting from boiler steam capacity of 50-75 t/h while stoker firing of RDF could be efficiently implemented for lower range. The design of such boiler should rely upon lessons learned of commissioning and operating large-scale CFB boiler (having steam capacity of 670 t/h; 545/545 C) we obtained at Starobeshevo Power Plant in Ukraine. Accounting for the above the analysis of implementation and modifications made at large-scale CFB boiler (cyclones, seal pot, fluidized bed heat exchangers) has been done. The experience was used to design (along with KB “Energomashproekt”) medium-scale CFB boiler (having steam capacity of 75 t/h; 500 C) to burn high ash coal washering wastes and RDF/SRF. The sketch-3D-design of such boiler is presented with key performance. Bibl. 6, Fig. 4, Tab. 4.
50
Ismailov, Namig I., and Sevinj N. Osmanova. "Azo-substituted ethoxyacridine – reagents for the extraction-photometric determination of gallium." Butlerov Communications 58, no. 5 (2019): 70–74. http://dx.doi.org/10.37952/roi-jbc-01/19-58-5-70.
Full textAbstract:
The associates of halide (chloride) complexes of gallim azo-substituted ethoxyacridine have been studied by spectrophotometric method. It has been found that the associates are well extracted with a mixture of dichloroethane-acetone (3:2). The optimum volume of aqueous and organic phase is equal to 5 ml. The molar ratio of the components in the extractable compounds was studied by the methods of isomolar series, equilibrium shift and a straight line. It was found that gallium chloride associated with azo-ethoxyacridines (AE) in a ratio of 1:1. It was studied formation and extraction of associates of gallium chloride with AEADPA (2-ethoxy-6-(4-N,N-dipropylphenylazo)-9-aminoacridine) and AEAN (2-ethoxy-6-(2-hydroxynaphthylazo)-9aminoacridine). The maxima of light absorption of gallium chloride with AEADPA is observed at 520 nm, and the AEAN at 510 nm. The light absorption of the extracts of associates coincides with the absorption maxima of azoethoxyacridines, which indicates the electrostatic character of the interaction and the formation of complexes. Study of the effect of foreign ions on the accuracy of the determination of gallium with azo-substituted ethoxyacridine showed that the number of ions does not interfere (in parentheses are multiple relationships to gallium ions); Zn2+ (2000), NiII (1500), CuII (2500), CoII (1400), Cr III(1100), PbI (2250), Al3+(1600), Cd2+(700), FeII (1050), ReVII (500), PdIII (1200), Tl (2500). Number of ions interfered the determination: TeIV(1), FeIII (1), AuIII (1), SbV(1), TlIII(1), SeIV(3). The physico-chemical and analytical characteristics of the azo-substituted ethoxyacridines and their ionic associates with chloride gallium acidic complexes (λmax ε, βkD, D, R%) were determined. It was shown that chloro-gallium compounds with azo-substituted ethoxyacridines are ionic associates, the molar ratios of the components in which are: [Ga3+] : [Cl-] : R+ = 1:4:1.