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Academic literature on the topic 'Réactif de Grignard'
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Journal articles on the topic "Réactif de Grignard"
Bram, Georges, Eric Peralez, Jean-Claude NÉgrel, and Michel Chanon. "Victor Grignard et la naissance de son réactif." Comptes Rendus de l'Académie des Sciences - Series IIB - Mechanics-Physics-Chemistry-Astronomy 325, no. 4 (August 1997): 235–40. http://dx.doi.org/10.1016/s1251-8069(97)88283-8.
Full textBremer, Therese, and H. Friedmann. "Note sur l'autoxydation chimiluminescente des réactifs de Grignard." Bulletin des Sociétés Chimiques Belges 63, no. 7-8 (September 1, 2010): 415–18. http://dx.doi.org/10.1002/bscb.19540630705.
Full textDissertations / Theses on the topic "Réactif de Grignard"
Péralez, Eric. "Contribution à la détermination du mécanisme de formation du réactif de Grignard." Aix-Marseille 3, 1996. http://www.theses.fr/1996AIX30092.
Full textBoukattaya, Fatma. "Addition d'organomagnésiens sur des nitriles fonctionnalisés : application à la synthèse de molécules d’intérêt biologique." Thesis, Le Mans, 2016. http://www.theses.fr/2016LEMA1007.
Full textThe nucleophilic addition of Grignard reagents on nitriles generally leads to ketones after acidic hydrolysis. The double addition, providing tertiary carbinamines after work-up, is more difficult and usually occurs only with allylic Grignard reagents. In this context, we discovered that Grignard reagents can perform a double addition on the nitrile function of acyl cyanohydrins, to provide hydroxyamides. This reaction is original by the fact that a wide range of Grignard reagents can be used, in particularly mild conditions. This reaction has been applied to the synthesis of different α,α-disubstituted α-aminoacids, by oxidation of the alcohol functionality and hydrolysis of the amide moiety. Especially, divinylglycine has been prepared in good yield. The successive addition of two different Grignard reagents was also carried out, after optimization of reaction conditions, to access unsymmetrical hydroxyamides, which are precursors of chiral quaternary aminoacids. Finally, the addition of the Grignard reagents on N-ethoxycarbonyl 3-cyano-iminocoumarines was studied. Despite the presence of several electrophilic centers, the reaction is highly chemoselective, and novel chromenes displaying substituent on position 4 were obtained. The antifungal and antibacterial properties of these compounds have been evaluated
Hazimeh, Hassan. "Réactivité des horloges radicalaires aromatiques vis-à-vis du magnésium, du potassium et de l'électron solvaté : transfert d'électron hétérogène versus homogène et mécanisme de formation du réactif de Grignard." Aix-Marseille 3, 2005. http://www.theses.fr/2005AIX30048.
Full textThis thesis investigates the mechanism of formation of aromatic organomagnesium compounds. We prepared a set of new radical clocks. Experiments with magnesium show that aryl radicals are formed. We showed that root of the selectivity between linear and cyclized Grignard reagents is highly dependent upon the zone where radicals are formed. The phenyl group present in our radical clocks could play an original role of mediator. Experiments with potassium and solvated electron reveal a dramatic difference between heterogeneous and homogeneous electron transfer : percentages of cyclised products diminish strongly in heterogeneous medium. The main cause of this contrasting behaviour could be the higher reducing efficiency of the metallic surface. We propose a new mechanism based on the electrochemical model developped by Savéant and Amatore (kinetic zone approach). This approach brings a fresh view about the root of selectivity during the formation of aromatic Grignard reagents
Caillé, Julien. "Réactivité d’organométalliques sur des nitriles fonctionnalisés : réactions de cyclopropanation asymétrique et double addition." Thesis, Le Mans, 2017. http://www.theses.fr/2017LEMA1028.
Full textCyclopropylamines are important scaffolds in medicinal chemistry. Among the syntheses of the aminocyclopropane moiety, the Kulinkovich-related reactions applied to amides and nitriles furnish straightforward access. However, no efficient asymmetric version has been published to date. In a first part, the study of optically active titanium complexes for the preparation of chiral spirolactams from cyanoesters has been undertaken. This work allowed us to setup a quick evaluation method for chiral ligands whose screening revealed that Taddol and its derivatives lead to the best enantiomeric excesses. However, the enantioselectivity remains too low for synthetic purposes. In a second part, the synthesis of tertiary carbinamines, another important scaffold, has been studied from acylcyanohydrins and organometallics. Notably, the synthesis of a quaternary aminoacids library was achieved. The incorporation of two different organometallics on acylcyanohydrins was also undertaken, leading to the preparation of chiral hydroxyamides in a racemic fashion. Lastly, very good yields in double addition products were obtained by using allylic organozinc reagents. The obtained hydroxyamides were used as precursors of polyfunctional linkers for the chemical ligation
Barré, Baptiste. "Fonctionnalisation d'hétérocycles par des réactions métallo-catalysées." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066461.
Full textCross-coupling reactions, as Prof. K. C. Nicolaou said “have changed the way we think about synthesis”. Indeed, cross-coupling reactions are powerful tools to access easily and rapidly to a library of compounds in the context of medicinal chemistry. Palladium-catalysed cross-coupling rules the field and was recognized by the Nobel Prize in 2010 but, since its discovery, others metals have appeared as good alternatives to the expensive and toxic palladium salts such as copper, nickel, cobalt and iron salts. In medicinal chemistry, heterocycles are essential moieties since they are found in a great number of drugs on the market. It is always a challenge for organic chemists to develop new methods to produce motifs with interesting pharmacological properties such as substituted azetidines, pyrrolidines and oxetanes. sp3 Halides are challenging substrates for cross-coupling because the oxidative addition of the metal in the C-X bond is difficult and because side reactions can take place like -hydride elimination or dehydrohalogenation. Nevertheless, cobalt and iron are suitable catalysts to perform cross-coupling reactions on sp3 halides. Herein, we would like to report two catalytic systems allowing the cross-coupling between heterocyclic alkyl halides and Grignard reagents using cobalt and iron salts. A mechanistic study on cobalt-catalysed cross-coupling reaction between halides and Grignard reagents will be also presented
Ben, Hassen Samia. "Electrodéposition du magnésium à partir des solutions à base de réactifs de Grignard et tenue à la corrosion du revêtement formé." Besançon, 2009. http://www.theses.fr/2009BESA2037.
Full textMagnesium deposits were applied as cathodic coatings to protect steel against corrosion. These magnesium deposits were obtained by electrodeposition with direct current method from six different Grignard solutions in their appropriate solvents. Ln aggressive chloride solutions, the best corrosion protection efficiency was obtained with magnesium deposit electroplated from methylmagnesium chloride solution in tetrahydrofurane. The use of pulsed current method improved remarkably the morphology and the texture of the magnesium deposit and consequently the corrosion protection efficiency was also enhanced. However this protection efficiency is time limited. In order to improve the time life of the magnesium coating, cerium treatments were applied. The obtained cerium conversion layer was mainly composed by ceria CeO2 which reinforced the corrosion protection by a barrier mechanism. In this work, electrochemical and analytical analyses were assumed with these following techniques: open circuit potential, polarization curves, EIS, SEM, EDS, XRD, FTIR and SDL
Aissaoui, Regadia. "Réaction de substitution nucléophile aromatique des acides naphtoïques ortho-fluorés/méthoxylés avec les réactifs de Grignards et les organolithiens (SNArAB)." Phd thesis, Université du Maine, 2012. http://tel.archives-ouvertes.fr/tel-00684960.
Full textYoussefi, Mohammad. "Recherche de nouvelles synthèses de sélénophosphonates : Préparation et étude de la réactivité d'ène-phosphoramides fonctionnels." Nancy 1, 1986. http://www.theses.fr/1986NAN10105.
Full textBoutahir, Driss. "Étude théorique de la structure et de la réactivité des réactifs de Grignard." Nancy 1, 1992. http://www.theses.fr/1992NAN10054.
Full textAndersen, Claire. "Catalyse au cobalt et au cuivre : Couplages croisés entre des (pseudo)halogénures d'alkyle et des réactifs de Grignard." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLET048.
Full textMost of the marketed drugs contain one or more aromatic rings in their structure. Even though, those moieties are often essential for a molecule to interact with its target, a too high number of aromatic rings can have a negative impact on the physico-chemical properties and on the toxicity of a drug candidate. It is therefore of high interest to replace a phenyl ring by bioisosteres, such as strained cycles (cyclopropane, cyclobutane, bicyclo[1.1.1]pentane). During the course of this thesis, two methods have been developed for the cross-coupling of alkyl (pseudo)-halides with several Grignard reagents containing strained cycles. The first method relies on a cobalt catalytic system and allow the cross coupling of the cyclopropylmagnesium bromide as well as the cyclobutylmagnesium bromide with alkyl iodides. The cross-coupling has also been extended to the use of alkenyl Grignard reagents. The second method uses a copper salt to achieve the cross-coupling of alkyl (pseudo)-halides with bicyclo[1.1.1]pentane Grignard reagents. Both cross-coupling are robust, easy-to-handle and simple and cheap catalysts are used. As these cross-couplings are chemoselective they are promissing powerful synthetic tools for medicinal chemists