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Relevant bibliographies by topics / Reactif grignard

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Academic literature on the topic 'Reactif grignard'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Reactif grignard"

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Clark, Peter D., Russell S. Mann, and Kevin L. Lesage. "Reactions of dimethyl polysulfides with organomagnesium reagents." Canadian Journal of Chemistry 70, no. 1 (January 1, 1992): 29–33. http://dx.doi.org/10.1139/v92-006.

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Reactions of a mixture of dimethyl polysulfides (DMPS, CH3SxCH3, x = 3 – 8) with methyl- and phenylmagnesium halides are described. The type of product obtained was dependent on the molar ratio of DMPS to Grignard reagent. When a 6:1 methyl-Grignard to DMPS ratio was used, methanethiol and dimethyl sulfide were the major products obtained after acidification of the reaction mixture. Lesser quantities of methyl-Grignard favored the formation of dimethyl sulfide, dimethyl disulfide, and H2S. Experiments with a 6:1 phenylmagnesium bromide to DMPS ratio produced benzenethiol and phenylmethyl sulfide as major products after acidification. No methanethiol was observed in these experiments. Mixtures of phenylmethyl mono-, di-, and trisulfides and H2S were obtained with a 3:1 Grignard/DMPS molar ratio. From a mechanistic viewpoint, product distributions obtained from reaction of Grignard reagents with DMPS can be explained by the formation of magnesium thiolates that are most readily stabilized by adjacent structures. Experiments using phenyl Grignard reagent in limited supply suggested that the internal sulfur atoms of the polysulfide chains were most reactive. Keywords: organic polysulfides, Grignard reagents.

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Dai, Zhi Qun, Zhi Yong Zhang, Wei Wei Zhang, and Ben Mei Wei. "Cross-coupling Reaction of Grignard Reagents with Alkyl Halides Catalyzed by Green, Economical Copper Bromide Catalyst." Advanced Materials Research 233-235 (May 2011): 1119–22. http://dx.doi.org/10.4028/www.scientific.net/amr.233-235.1119.

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For the first time a systematic research on the catalytic activity of CuXn(X=Cl, Br, I; x=1,2) for the cross-coupling reaction of alkyl halides with Grignard reagents was carried out and environmentally friendly, economical CuBr2showed highest catalytic activity among the catalyst. The conditions of the cross-coupling reaction were studied. The suitable amount of catalyst, reaction temperature and time are 0.3% mol (based on alkyl halide), 67°C (reflux), 6 h, respectively. Under the optimal conditions, the yields of the cross-coupling could reach up to 93%. Moreover, Grignard reagent with an electron-rich group reacted rapidly and with an electron-withdrawing group reacted sluggishly.

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Wang, Xiang Cheng, Jian Li, Jian Bing, and Gao Yun Chen. "Study on Preparation of Octyltrimethoxysilane." Advanced Materials Research 712-715 (June 2013): 298–301. http://dx.doi.org/10.4028/www.scientific.net/amr.712-715.298.

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Octyltrimethoxysilane was synthesized by octane and trimethoxysilane, and octane was synthesized by grignard reagent. The main effects of reacting conditions on the yield were discussed and the optimum experimental conditions were studied. Used 3-bromopropene and 1-Brompentane as raw materials, the molar ratio of octane: magnesium was 1:1.2. Droplets time was 3 hours, the reacting time in 1 hour, and yield was 45.6%. Target compounds were analysised through GC-MS. Then, used choroplatinicacid isopropanol as catalyst, octane reacted with trimethoxysilane to gain octyltrimethoxysilane, the time of activation of catalyst was 1 hour ,reacting time 1 hour, and the yield was up to 65.4%. Study found that using 1-Brompentane Grignard reagent and 3-bromopropene could extend the carbon chain successfully. On the contrary, using 3-bromopropene Grignard reagent and 1-Brompentane to react, the rate of conversion was very low, a large number of decane generated, rather than octane.

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Grouiller, Annie, and Hassan Essadiq. "Behaviour of 2′-O-p-toluenesulfonyl uridine towards excess of a Grignard reagent." Canadian Journal of Chemistry 67, no. 4 (April 1, 1989): 708–9. http://dx.doi.org/10.1139/v89-108.

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Two C-methylated base nucleosides were obtained when 2′-O-tosyl-5′-O-trityluridine was reacted with 30 equivalents of methylmagnesium iodide. Keywords: nucleoside, Grignard reaction, C-methyl pyrimidinone, anhydro derivative, arabinofuranosyl.

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Chavan, Subhash P., Harshali S. Khatod, Tamal Das, and Kumar Vanka. "Exploration of the diastereoselectivity in an unusual Grignard reaction and its application towards the synthesis of styryl lactones 7-epi-(+)-goniodiol and 8-epi-(−)-goniodiol." RSC Advances 6, no. 56 (2016): 50721–25. http://dx.doi.org/10.1039/c6ra03192g.

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Knochel, Paul, Eike Hupe, Wolfgang Dohle, David M. Lindsay, Véronique Bonnet, Guy Quéguiner, Andreas Boudier, et al. "Functionalized main-group organometallics for organic synthesis." Pure and Applied Chemistry 74, no. 1 (January 1, 2002): 11–17. http://dx.doi.org/10.1351/pac200274010011.

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Highly functionalized Grignard-reagents can be easily obtained by an iodinemagnesim exchange reaction and further reacted with various electrophiles. Via a BZn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.

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Katritzky, Alan R., Stanislaw Rachwal, and Jing Wu. "A versatile method for the N, N-dialkylation of aromatic amines via Grignard reactions on N,N-bis(benzotriazolylmethyl)arylamines." Canadian Journal of Chemistry 68, no. 3 (March 1, 1990): 456–63. http://dx.doi.org/10.1139/v90-069.

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Grignard reactions of N,N-bis(benzotriazolylmethyl)arylamines afford the corresponding N,N-dialkylarylamines in high yields. Electron-releasing substituents on the aryl ring facilitate the reaction. Arylamines are N,N-dialkylated with two different alkyl groups by a stepwise procedure: N-benzotriazolylmethylation of an amine followed by a Grignard reaction to introduce the first alkyl group, and repetition of the same procedure to introduce the second alkyl group. Grignard reagents derived from 1,4-dihalobutane, upon reaction with N,N-bis(benzotriazolylmethyl)arylamines, give the corresponding N-aryl-hexahydroazepines together with acyclic products. Keywords: azepine, tertiary arylamines.

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Cai, Mingzhong, Chunyun Peng, Hong Zhao, and Wenyan Hao. "A Stereoselective Synthesis of (E)-Allylic Alcohols Via the Hydromagnesiation of Alkynylsilanes." Journal of Chemical Research 2003, no. 5 (May 2003): 296–98. http://dx.doi.org/10.3184/030823403103173877.

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Hydromagnesiation of alkynylsilanes 1 gives ( Z)-α-silylvinyl Grignard reagents 2, which are reacted with aldehydes or ketones to afford ( Z)-β-silyl allylic alcohols 3 in high yields; intermediates 3 can undergo the desilylation reaction in the presence of anhydrous KF to give ( E)-allylic alcohols 4 in good yields.

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Bhat, Balkrishen, and A. P. Bhaduri. "Grignard Reaction of 2-Substituted-3-Cyanoquinolines." Zeitschrift für Naturforschung B 40, no. 7 (July 1, 1985): 990–95. http://dx.doi.org/10.1515/znb-1985-0724.

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Abstract Grignard reactions of 2-morpholino and 2-methylthio-3-cyanoquinoline, 2-chloro-3-cyanoquinoline, 2-chloro-3-cyano-6-methoxyquinoline and 2-chloro-3-cyano-7-methylquinoline with alkyl or aryl magnesium halides have been studied. It was found that 2-morpholino and 2-methylthio- 3-cyanoquinolines gave 1,4-addition products followed by rapid aromatisation. 2-Chloro-3- cyanoquinoline with alkyl magnesium halides furnished 1,4-addition products but with aryl magnesium halides 1,4- and 1,2-addition products were obtained. The cyano group of 4-aryl-2-chloro- 3-cyano-1,4-dihydroquinolines was found to participate in the Grignard reaction to yield 1,2- addition products. 2-Chloro-3-cyano-6-m ethoxyquinoline with alkyl and phenyl magnesium halides yielded exclusively 1,4-addition products. Similarly with p-m ethoxyphenyl magnesium bromide, 1,4-addition products were isolated which participated in the Grignard reaction to yield the expected adducts. Unlike the other chloroquinoline derivatives, 2-chloro-3-cyano-7-methylquinoline with alkyl magnesium halide formed 1 ,2-addition products but with aryl magnesium halides, 1,4-addition products were isolated. The 4-alkyl-2-chloro-3-cyano-l,4-dihydroquinolines were unstable as compared to their 4-aryl analogs. A couple of the Grignard reaction products were found to be unstable on activated surface.

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Zhao, Hong, and Mingzhong Cai. "Alkynylsilanes as Convenient Precursors for the Stereoselective Synthesis of (E)-Disubstituted Alkenes." Journal of Chemical Research 2002, no. 12 (December 2002): 608–10. http://dx.doi.org/10.3184/030823402103170961.

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Hydromagnesiation of alkynylsilanes 1 gives (Z)-α-silylvinyl Grignard reagents 2, which are reacted with alkyl iodides or aryl iodides in the presence of CuI or Pd(PPh3)4 catalysts to afford (Z)-1,2-disubstituted vinylsilanes 3 in good yields. Intermediates 3 can undergo a desilylation reaction to give (E)-disubstituted alkenes 4 in high yields.

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Dissertations / Theses on the topic "Reactif grignard"

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Alvarez, Gonzalez Eleuterio. "Substitution d'ethers et d'alcools allyliques par differents nucleophiles en presence de complexes de nickel(0) : synthese stereoselective des dienes-1,4 a partir des sulfones dieniques avec le chlorure d'isopropylmagnesium en presence de sels de." Paris 6, 1987. http://www.theses.fr/1987PA066064.

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Andersson, Hans. "Reaction between grignard reagents and heterocyclic N-oxides synthesis of substituted pyridines, piperidines and piperazines /." Doctoral thesis, Umeå : Department of Chemistry, Umeå University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25619.

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DUCOUX, JEAN-PHILIPPE. "Utilisation de reactifs de grignard actives par des complexes de nickel dans la synthese de produits naturels insatures." Paris 11, 1991. http://www.theses.fr/1991PA112061.

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Une methode generale de synthese stereospecifique de motifs dieniques 1,5- et 1,6- a ete developpee: la reaction de reactifs de grignard actives par des complexes de nickel adequats sur le dihydrofurane et le dihydropyrane, dont la configuration de la double liaison est preetablie. Elle a permis l'acces rapide et stereoselectif (z=99%) a des alcools homo- et bis-homoallyliques z. A partir du dihydrofurane et en repetant la reaction, on peut obtenir des dienes 1,5 et 1,6- a partir du dihydropyrane. Ces resultats ont ete appliques a la preparation a grande echelle de pheromones d'insectes: l'acetate de (6z,11z)-hexadeca-6,11-dien-1-yle, pheromone d'eudia pavonia, et le (5z,9z)-heptacosa-5,9-diene, pheromone de drosophila melanogaster synthetisee pour la premiere fois pour identification. Une nouvelle synthese efficace et peu couteuse du gossyplure, pheromone du ver rose du cotonnier, melange 1:1 d'acetates de (7z,iie)- et de (7z,11z)-hexadeca-7,11-dien-1-yle a ete proposee. Elle a ete realisee a partir d'un melange 1:1 de (3z)- et (3e)-bromo-3-enes obtenu par isomerisation photochimique (decouverte fortuitement) de l'isomere z. Enfin, une autre potentialite de la reaction etudiee a ete mise en valeur. Elle consiste a privilegier la reaction de beta-elimination d'hydrogene sur des reactifs de grignard appropries (bromure d'isopropylmagnesium). A l'aide d'un complexe de nickel monodente, cette reaction effectuee sur des 6-alkyl-3,4-dihydro-2h-pyranes aboutit a des alcools 5-alkyl-bis-homoallyliques (e=95%)

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Patwardhan, Neeraj Narendra. "Study of Synthesis, Reactions and Enantiomerization of C_α-Chiral Grignard Reagents." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/37814.

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The development of chiral organometallics for asymmetric synthesis is a topic of significant research in the recent past. The most studied in this class are the chiral organolithium reagents with many reported examples. The primary focus of our research is the development of C_α-chiral Grignard reagents, where the metal bearing α-carbon is the sole source of chirality. Examples of such Grignard reagents are rare owing to the problems associated with their synthesis, and their low configurational stability. We have studied these problems in three different modules of this project. Reactions of 1-magnesio-2,2-diphenyl-cyclopropylcarbonitrile with carbon electrophiles are first attempted in order to expand the utility of this configurationally stable C_α-chiral Grignard reagent in asymmetric synthesis. This reagent has been shown to be non-reactive towards carbon electrophiles at low temperatures. Consequently, we attempt to enhance the reactivity of this compound through two different approaches, Lewis-base activation and the "ate-complex" generation. The Magnesium/Halogen (Mg/X) exchange reactions have been shown to be extremely useful in the synthesis of complex Aryl, alkenyl (sp²) and alkynyl (sp) Grignard reagents. Examples of Mg/X exchange reactions of Alkyl (sp³) halides are, however, rare. Even more rare are such examples with secondary and tertiary alkyl halides, justifying the relative paucity of chiral Grignard reagents. In this module of our project, we study the Mg/X exchange reactions on secondary alkyl halides possessing a γ-hydroxyl group, as an internal activator for such Mg/X exchange reactions. Enantiomerization pathways of chiral organolithium compounds have been widely studied. However, few such studies have been performed on chiral Grignard reagents. In this module of the project, we studied the solvent assisted enantiomerization mechanism of the C_α-chiral 1-magnesio-2,2-diphenyl-cyclopropylcarbonitrile. Rate constant for the enantiomerization of this compound was measured in three different ethereal solvents to study the effect of solvent on the configurational stability. Finally, the order of the enantiomerization process with respect to [Et₂O] was studied in order to predict the mechanism of this process in Et₂O solvent. Our kinetic studies on the enantiomerization process provided us with a definitive picture for the enantiomerization of the C_α-chiral 1-magnesio-2,2-diphenyl-cyclopropylcarbonitrile, where solvation of the Grignard reagent preceded an ion-pair separation step which eventually lead to enantiomerization of the Grignard species. However, the precise structure of all the involved solvated intermediates could not be determined as kinetics was not able to distinguish between these intermediates. We next performed computational calculations to study the effect of solvation on the analogous 1-magnesio-cyclopropylcarbonitrile in order to address the unanswered questions from our kinetic studies.
Ph. D.

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Srđan, Bjedov. "Sinteza i biološka ispitivanja novih derivata žučnih kiselina." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2017. https://www.cris.uns.ac.rs/record.jsf?recordId=104087&source=NDLTD&language=en.

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U disertaciji je ostvarena sineza amida i oksazolina žučnih kiselina, kao i njihovih alkil i alkilidenskih derivata polazeći od holne kiseline. Ipitano je ponašanje različitih okso derivata žučnih kiselina u uslovima Grignard-ove i Wittig-ove reakcije. Ispitana je biološka aktivnost odabranih sintetizovanih jedinjenja
Synhesis of bile acid amide and oxazoline derivatives, and their alkyl and alkylidene derivatives was accomplished starting from cholic acid. Also, chemical behavior of different bile acid oxo derivatives in Grignard and Wittig reaction was investigated. Biological activity of selected synthesized compounds was evaluated.

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Blomberg, David. "Synthesis of β-turn and pyridine based peptidomimetics." Doctoral thesis, Umeå universitet, Kemi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1104.

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Despite the unfavorable pharmacokinetic properties associated with peptides, they are still of great interest in drug development due to a multitude of interesting biological functions. The development of peptidomimetics strives to maintain or improve the biological activity of a peptide concurrently with removing the unwanted properties. This thesis describes two synthetic approaches to peptidomimetics with particular emphasis on secondary structure mimetics. First the design, synthesis and evaluation of two beta-turn mimetics incorporated in the endorphin Leu-enkephalin is presented. The beta-turn mimetics were stabilized by replacement of the intramolecular hydrogen bond with an ethylene bridge, and the amide bond between Tyr and Gly was replaced with an ether linkage. Linear analogues of the two mimetics were also synthesized. The peptidomimetics and their linear analogues were evaluated in a competitive binding assay at two opiate receptors, my and delta. One of the cyclized beta-turn mimetics was found to be a delta receptor antagonist with an IC50 value of 160 nM. Second a synthetic strategy to a beta-strand mimetic using 2-fluoro-4-iodopyridine as scaffold is described. The synthesis involved a Grignard exchange reaction on the pyridine scaffold using an amino acid derivative as electrophile followed by an SNAr reaction using an amine as nucleophile. The synthesis of a tripeptidomimetic of Leu-Gly-Gly and attempts to introduce chiral building blocks at the C-terminal, as well as studies towards elongated mimetics are presented. Two additional studies deal with the synthesis of two classes of potential thrombin inhibitors based on the pyridine scaffold. The first class contain pyridine as central fragment (P2 residue) substituted with a para-amidinobenzylamine group as P1 residue and various benzoyl groups as P3 residues. Three potential thrombin inhibitors were synthesized and found to be microM inhibitors in an enzymatic assay. In the second class, the pyridine ring serves as P3 residue. This class also lacks a strongly basic group in the P1 position. A small library of eight compounds were synthesized and evaluated in the enzymatic assay. Unfortunately, these compounds lacked inhibitory activity.

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Neouchy, Zeïna. "Couplage croisé d’éthers d’énol méthyliques par activation de liaisons C(sp2)-OCH3 catalysée par le nickel et Synthèse d’amines α-trifluorométhylées acycliques optiquement activespar réarrangement de β-aminoalcools α-trifluorométhylés." Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLET016.

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En chimie organique, le développement de méthodes de synthèse robustes et respectueuses de l’environnement a toujours été un défi. De plus, en chimie médicinale, la mise au point de méthodes de synthèse de synthons fluorés de haute valeur ajoutée sont importantes pour avoir accès à des composés bioactifs. Dans ce manuscrit, nous présentons des méthodes efficaces et faciles à mettre en œuvre pour la formation de liaisons carbone-carbone catalysée par le nickel et la formation de liaisons carbone hétéroatome par un réarrangement de β aminoalcools α-trifluorométhylés.Nous avons montré que le couplage croisé entre un éther d’énol méthylique et un réactif de Grignard pouvait être catalysé par un système simple à base de Ni(OAc)2/(O)PPh3 dans des conditions douces (40°C) via l’insertion du nickel dans la liaison C-OMe. Cette méthode a été appliquée à la synthèse d’un composé antitumoral, le DMU-212.La synthèse d’amines α-trifluorométhylées linéaires énantioenrichies a été réalisée selon une réaction de réarrangement régiosélectif de β-aminoalcools α-trifluorométhylés en se basant sur une stratégie établie dans le laboratoire via un intermédiaire aziridinium. Nous avons montré que les produits obtenus pouvaient être engagés dans des réactions de post-fonctionnalisation
In organic chemistry, the development of robust and sustainable synthetic methods has always been a challenge. Moreover, in medicinal chemistry, the development of fluorinated building blocks synthetic methods with high value is important to access bioactive compounds. In this manuscript, we report efficient and easy to carry methods for the formation of carbon-carbon bonds catalyzed by nickel and the formation of carbon-heteroatom bonds by a rearrangement of α-trifluoromethyl-β aminoalcools.We demonstrated that it is possible to perform a cross-coupling reaction of an alkenyl methy ether with a Grignard reagent using a simple catalytic system based on Ni(OAc)2/(O)PPh3 under mild conditions (40°C) via the insertion of nickel into C-OMe bond. This method has been applied to the synthesis of an antitumoral agent, DMU-212.The synthesis of enantioenriched linear α-trifluoromethylamine derivatives is reported consisting in a rearrangement of α-trifluoromethyl-β aminoalcool based on an established strategy in our group via an aziridinium intermediate. We have shown that the synthesized compounds can be involved in post-functionalization reactions

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Toledano, Navarro Estefanía. "Síntesis Asimétrica de Heterociclos Nitrogenados vía Adición de Triorganozincatos con Cadenas Insaturadas a N-(terc-Butilsulfinil)iminas." Doctoral thesis, Universidad de Alicante, 2015. http://hdl.handle.net/10045/83547.

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En esta memoria se describe la síntesis de N-(terc-butilsulfinil)iminas promovida por microondas, así como su aplicación a la preparación de diferentes heterociclos nitrogenados ópticamente enriquecidos por adición diastereoselectiva de reactivos organozíncicos. Esta memoria ha sido dividida en los siguientes capítulos: Capítulo I: Síntesis de N-(terc-Butilsulfinil)iminas promovida por microondas. En este capítulo se describe la síntesis de diferentes aldiminas y cetiminas por condensación del correspondiente aldehído o cetona con 2-metilpropano-2-sulfinamida en ausencia de disolvente y promovida por microondas. Capítulo II: Síntesis de N-heterociclos. En este capítulo se ha llevado a cabo la preparación de heterociclos nitrogenados de diferentes tamaños a partir de los productos generados por adición diastereoselectiva de triorganozincatos con sustituyentes insaturados a las iminas obtenidas en el capítulo I.

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Goran, Benedeković. "Enantiodivergentna totalna sinteza odabranih stiril laktona i preliminarno ispitivanje njihove citotoksičnosti." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2012. http://dx.doi.org/10.2298/NS20121011BENEDEKOVIC.

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U radu je ostvarena enantiodivergentna totalna sinteza oba enantiomera goniofufurona, 7-epi-goniofufurona i krasalaktona C polazeći iz D-glukoze. Ključne faze u sintezi 7-epi-(+)-goniofufurona bile su stereoselektivna adicija fenilmagnezijum bromida na aldehidnu grupu pogodno zaštićene dialdoze, i stereospecifično formiranje furano-laktonskog prstena ciklokondenzacijom odabranog hemiacetalnog derivata sa Meldrum-ovom kiselinom. Sinteza (+)-goniofufurona i (+)-krasalaktona C zahtevala je inverziju konfiguracije na C-5u zajedničkom intermedijeru, koja je efikasno ostvarena u uslovima Mitsunobu-ove reakcije, ili alternativno oksidacijom benzilne hidroksilne grupe u prohiralni keton, uz naknadnu stereoselektivnu redukcijom sa borohidridom. Sličan pristup je zatim primenjen za sintezu neprirodnih (−)-enantiomera goniofufurona, 7-epi-goniofufurona i krasalaktona C, dva nova konformaciono ograničena analoga (+)- i (−)-goniofufurona (oksetani 36 i ent-36), kao i odgovarajućih 7-deoksigenovanih derivata (31 i ent-31). Takodje je razvijena i prva totalna sinteza prirodnog (+)-krasalaktona B (3) i alternativna sinteza (+)-krasalaktona C (4) polazeći iz D-glukoze. Selektivni pristup molekulima 3, odnosno 4 omogućen je promenom uslova za TBDPS deprotekciju u finalnom intermedijeru 53. Osnovna karakteristika pomenutih pristupa je njihova generalnost i fleksibilnost. Na taj način je omogućena sinteza serije analoga i derivata (+)-goniofufurona, ili 7-epi-goniofufurona, uključujući i do sada nepoznate 7-epi-(+)-krasalaktone B (6) i C (7), 5,7-di-O-cinamoil derivate 8 i 9, 5,7-di-O-izopropilidenske derivate 5 i 10, kao i više lipofilnih derivata (jedinjenja 26, 30, 33, 65, ent-30 i ent-33). Konačno, u drugom delu rada, ispitan je uticaj sintetizovanih stiril-laktona na rast odabranih tumorskih ćelijskih linija in vitro.
Enantiodivergent total syntheses of both (+)- and (−)-enantiomers of goniofufurone, 7-epi-goniofufurone and crassalactone C have been accomplished starting from D-glucose. The key steps of the synthe-sis of 7-epi-(+)-goniofufurone were a stereo-selective addition of phenyl magnesium bromide to a protected dialdose, followed by a stereospecific furano-lactone ring formation by condensation of a partially protected lactole with Meldrum’s acid. The synthesis of (+)-goniofufurone and (+)-crassalactone C required a configurational inversion at C-5 in the common intermediate that was efficiently achieved under the standard Mitsunobu conditions, or alternatively through a sequential oxidation of the benzylic hydroxyl group followed by a stereo-selective reduction with borohydride. A similar approach was applied to the synthesis of the unnatural enantiomers of goniofufurone, 7-epi-goniofufurone and crassalactone C, two novel, conformationally constrained analogues of both (+)- and (−)-goniofufurone (oxetanes 34 and ent-34). as well as the corresponding 7-deoxygenated derivatives (31 and ent-31). We have also developed the first total synthesis of (+)-crassalactone B (2) and an alternative synthesis of (+)-crassalactone C (3) starting from D-glucose. Finally, the synthesized styryl-lactones were evaluated for their antiproliferative activity against a panel of human tumor cell lines.

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Youssefi, Mohammad. "Recherche de nouvelles synthèses de sélénophosphonates : Préparation et étude de la réactivité d'ène-phosphoramides fonctionnels." Nancy 1, 1986. http://www.theses.fr/1986NAN10105.

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La recherche d'une méthode de synthèse de phénylséléno phosphate d'alkyle (RO)::(2)P(O)CH::(2)SePh a permis de trouver un nouveau réactif de Grignard (ETO)::(2)P(O)CH::(2)MGCL. Les propriétés de ce nouveau réactif ont été étudiées et comparées à celles des autres organométalliques correspondants connus lithiens et cuivreux. Ce réactif de Grignard conduit à une synthèse originale de sélénophosphonates. Utilisation des phosphates d'alkyle comme agents d'alkylation pour la synthèse de dithioesters. Des énephosphoramides fonctionnels ont été obtenus pour la première fois et la réactivité carbonique de l'un d'entre eux a été étudiée

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Book chapters on the topic "Reactif grignard"

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Li, Jie Jack. "Grignard reaction." In Name Reactions, 266–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01053-8_114.

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Li, Jie Jack. "Grignard reaction." In Name Reactions, 291–92. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_122.

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Li, Jie Jack. "Grignard reaction." In Name Reactions, 164–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_126.

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Li, Jie Jack. "Grignard Reaction." In Name Reactions, 231–34. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-50865-4_60.

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Maruyama, K., and T. Katagiri. "Grignard Reaction of Ketones. Electron and Subsequent R. Transfer Processes to Ketones." In Organic Free Radicals, 117–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73963-7_58.

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Bartoli, Giuseppe, Marcella Bosco, Renato Dalpozzo, and Loris Grossi. "Polar Versus Electron Transfer Pathway in the Reaction of Alkyl Lithium and Alkyl Grignard Reagents with Mononttroarenes: Factors Affecting Product Distribution." In Paramagnetic Organometallic Species in Activation/Selectivity, Catalysis, 489–502. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-0877-2_34.

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"The Barbier Reaction." In Handbook of Grignard Reagents, 433–68. CRC Press, 1996. http://dx.doi.org/10.1201/b16932-25.

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"43. Grignard Reaction." In Organic Chemistry: 100 Must-Know Mechanisms, 100–101. De Gruyter, 2020. http://dx.doi.org/10.1515/9783110608373-043.

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von Angerer, S. "Reaction with Grignard Reagents." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-017-00848.

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von Angerer, S. "Reaction with Grignard Reagents." In Six-Membered Hetarenes with Two Identical Heteroatoms, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-00710.

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Conference papers on the topic "Reactif grignard"

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Silva, Márcio S., Renan S. Ferrarini, Bruno A. Souza, Rogério A. Gariani, Fabiano T. Toledo, and João V. Comasseto. "Cross-Coupling Reaction of Organotellurides with Grignard Compounds Catalyzed by MnCl2/CuI." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0136-1.

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