Relevant bibliographies by topics / Reactive aldehydes

Academic literature on the topic 'Reactive aldehydes'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 February 2022

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Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Journal articles on the topic "Reactive aldehydes":

1

Hellenthal, Katharina E. M., Laura Brabenec, Eric R. Gross, and Nana-Maria Wagner. "TRP Channels as Sensors of Aldehyde and Oxidative Stress." Biomolecules 11, no. 10 (September 24, 2021): 1401. http://dx.doi.org/10.3390/biom11101401.

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The transient receptor potential (TRP) cation channel superfamily comprises more than 50 channels that play crucial roles in physiological processes. TRP channels are responsive to several exogenous and endogenous biomolecules, with aldehydes emerging as a TRP channel trigger contributing to a cellular cascade that can lead to disease pathophysiology. The body is not only exposed to exogenous aldehydes via tobacco products or alcoholic beverages, but also to endogenous aldehydes triggered by lipid peroxidation. In response to lipid peroxidation from inflammation or organ injury, polyunsaturated fatty acids undergo lipid peroxidation to aldehydes, such as 4-hydroxynonenal. Reactive aldehydes activate TRP channels via aldehyde-induced protein adducts, leading to the release of pro-inflammatory mediators driving the pathophysiology caused by cellular injury, including inflammatory pain and organ reperfusion injury. Recent studies have outlined how aldehyde dehydrogenase 2 protects against aldehyde toxicity through the clearance of toxic aldehydes, indicating that targeting the endogenous aldehyde metabolism may represent a novel treatment strategy. An addition approach can involve targeting specific TRP channel regions to limit the triggering of a cellular cascade induced by aldehydes. In this review, we provide a comprehensive summary of aldehydes, TRP channels, and their interactions, as well as their role in pathological conditions and the different therapeutical treatment options.
2

Monreal-Leyva, Isabel, Breanna Rose Attema, Nuri Bae, Haishi Cao, and Hector Palencia. "Benzoin condensation of aromatic aldehydes catalyzed by N-heterocyclic carbenes under mild conditions." European Journal of Chemistry 10, no. 1 (March 31, 2019): 1–6. http://dx.doi.org/10.5155/eurjchem.10.1.1-6.1826.

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The benzoin condensation was used to evaluate the catalytic activity of different N-heterocyclic carbenes as a function of their structure and N-substituents. There is a correlation between the length of an N-alkyl substituent and its performance as an organocatalyst. Heteroaromatic aldehydes were found to be the most reactive, among the screened substrates, finishing the reaction in 30 minutes, with almost quantitative yields. On the other hand, p-nitrobenzaldehyde, a strongly electrophilic aldehyde, was the least reactive. Electronic effects have little influence on the reaction yield but steric effects can dramatically reduce it. The preformed organocatalyst reacts faster than the generated in situ, with minimum solvent.
3

Patel, Ketan J. "Links Between DNA Damage and Metabolism, Pathways Causing Bone Marrow Failure in Fanconi Anemia, and Therapeutic Implications." Blood 120, no. 21 (November 16, 2012): SCI—3—SCI—3. http://dx.doi.org/10.1182/blood.v120.21.sci-3.sci-3.

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Abstract Abstract SCI-3 Recent work from my lab has discovered that metabolism generates reactive aldehydes. These reactive molecules are potent damagers of DNA. The consequences of this are revealed by the inactivation of enzymes that detoxify these aldehydes and the Fanconi anemia DNA repair pathway in mice and vertebrate cell lines. The scientific session presentation will discuss this work and recent unpublished research on how natural aldehydes damage blood stem cells. This work has consequences for understanding how metabolism and ethanol exposure can be genotoxic, particularly in the vast population of Southeast Asians carrying a genetic defect in aldehyde catabolism (“pink flushers”). It is also relevant to the emergence of bone marrow failure and leukemia in Fanconi anemia. Disclosures: No relevant conflicts of interest to declare.
4

Averill-Bates, Diana A., Enzo Agostinelli, Ewa Przybytkowski, and Bruno Mondovi. "Aldehyde dehydrogenase and cytotoxicity of purified bovine serum amine oxidase and spermine in Chinese hamster ovary cells." Biochemistry and Cell Biology 72, no. 1-2 (January 1, 1994): 36–42. http://dx.doi.org/10.1139/o94-006.

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Bovine serum amine oxidase (EC 1.4.3.6) catalyses the oxidative deamination of polyamines giving rise to the corresponding aldehydes, ammonia, and hydrogen peroxide. It has been suggested that the dialdehyde produced during the oxidation of spermine subsequently undergoes spontaneous β-elimination to form acrolein. Oxidation of the aldehydes by aldehyde dehydrogenase (EC 1.2.1.5) thus eliminates these reactive species and prevents the formation of acrolein. This work studies the role of each of the oxidation products of spermine in cytotoxicity induced by purified bovine serum amine oxidase. The inhibition patterns of NAD-dependent aldehyde dehydrogenase and catalase against cytotoxicity of bovine serum amine oxidase were determined in Chinese hamster ovary cells at 37 °C. Cytotoxicity caused by exogenous hydrogen peroxide, added directly (> 10 μM) or generated by glucose oxidase (0.5 U/mL), was completely inhibited by catalase. Cytotoxicity caused by bovine serum amine oxidase (5.7 × 10−3 U/mL) and spermine (340 μM) was completely inhibited by catalase only during short incubation times after which time cytotoxicity occurred. This indicates that hydrogen peroxide was the only species contributing to cytotoxicity at this stage of the reaction. Aldehyde dehydrogenase alone caused partial inhibition of cytotoxicity, but only later in the reaction. Cytotoxicity was completely eliminated in the presence of both catalase and aldehyde dehydrogenase. Exogenous acrolein (> 50 μM) also caused cytotoxicity in Chinese hamster ovary cells. However, hydrogen peroxide was toxic to cells at lower concentrations and at shorter exposure times relative to aldehydes. These data show that both peroxide and aldehydes contribute to cytotoxicity of oxidation products of spermine. Aldehydes such as acrolein are responsible for cytotoxicity that cannot be accounted for by hydrogen peroxide.Key words: acrolein, hydrogen peroxide, catalase, polyamine.
5

Lodge, J. K., S. U. Patel, and P. J. Sadler. "Aldehydes from metal ion- and lipoxygenase-induced lipid peroxidation: detection by 1H-n.m.r. spectroscopy." Biochemical Journal 289, no. 1 (January 1, 1993): 149–53. http://dx.doi.org/10.1042/bj2890149.

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The modification of lipoproteins by reactive aldehydes formed via lipid peroxidation is thought to be a key process in the pathogenesis of atherosclerosis. We show that 1H-n.m.r. spectroscopy can readily be used to detect a variety of different aldehydes resulting from peroxidation of liposomes induced by Fenton's reagent or lipoxygenase, and aldehydes arising from copper-induced reactions of low-density lipoprotein. There is a clear contrast between the major aldehydic products arising from metal-ion- and lipoxygenase-induced reactions.
6

Chevolleau, Sylvie, Maria-Helena Noguer-Meireles, Loïc Mervant, Jean-François Martin, Isabelle Jouanin, Fabrice Pierre, Nathalie Naud, Françoise Guéraud, and Laurent Debrauwer. "Towards Aldehydomics: Untargeted Trapping and Analysis of Reactive Diet-Related Carbonyl Compounds Formed in the Intestinal Lumen." Antioxidants 10, no. 8 (August 6, 2021): 1261. http://dx.doi.org/10.3390/antiox10081261.

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Lipid peroxidation and subsequent formation of toxic aldehydes, such as 4-hydroxynonenal, is known to be involved in numerous pathophysiological processes, possibly including the development of colorectal cancer. This work aimed at the development of an untargeted approach using high-performance liquid chromatography coupled with high-resolution mass spectrometry (HPLC–HRMS) for tracking aldehydes in both suspect screening and untargeted methods in fecal water, representing the aqueous environment of colon epithelial cells. This original approach is based on the introduction of a characteristic isotopic labeling by selective derivatization of the carbonyl function using a brominated reagent. Following a metabolomics workflow, the developed methodology was applied to the characterization of aldehyde compounds formed by lipid peroxidation in rats fed two different diets differentially prone to lipoperoxidation. Derivatized aldehydes were first selectively detected on the basis of their isotopic pattern, then annotated and finally identified by tandem mass spectrometry. This original approach allowed us to evidence the occurrence of expected aldehydes according to their fatty acid precursors in the diet, and to characterize other aldehydes differentiating the different diets.
7

Škulj, Sanja, and Mario Vazdar. "A Computational Insight into Reaction Between Different Amino Acids with Reactive Aldehydes 4-hydroxy-2-nonenal and 4-oxo-2-nonenal." Croatica chemica acta 92, no. 2 (2019): 229–39. http://dx.doi.org/10.5562/cca3579.

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In this work, we studied in detail the reaction mechanism of modification of arginine (Arg), cysteine (Cys) and histidine (His) model amino acids upon the reaction with biologically relevant reactive aldehydes 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE) in acetonitrile and acetonitrile/water systems by using high level ab initio calculations. We identified and characterized all of the reaction steps along two possible pathways – Michael addition pathway and Schiff base pathway resulting in the formation of Michael adducts/hemiacetals and carbinolamine/Schiff base adducts, depending on the reactive aldehyde and the reaction pathway. Overall energetics suggests that Arg amino acid is more reactive than Cys and His amino acids in both reaction pathways. We established that the ONE is in general more reactive than HNE and also found out that addition of water in the reaction steps involving proton transfer strongly catalyzes the reaction by decreasing prohibitively high free energy barriers.
8

Czaplicka, Marianna, and Michał Chrobok. "Selected carbonyl compounds in the air of Silesia region." E3S Web of Conferences 28 (2018): 01006. http://dx.doi.org/10.1051/e3sconf/20182801006.

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This study was carried out to characterize three aldehydes of health concern (formaldehyde, acetaldehyde, and acrolein) at a three sites in Silesian region (Poland) in January and June 2015. Aldehydes in polluted atmospheres comes from both primary and secondary sources, which limits the control strategies for these reactive compounds. Average aldehyde concentration in summer period lies in range from 3.13 μg/m3 to 10.43 μg/m3, in winter period in range from 29.0 μg/m3 to 32.2 μg/m3. Acetaldehyde was dominant compound in winter period, in summer formaldehyde concentration was highest of all determined aldehydes.
9

Juhl, Martin, Myungjo Kim, Hee-Yoon Lee, Mu-Hyun Baik, and Ji-Woong Lee. "Aldehyde Carboxylation: A Concise DFT Mechanistic Study and a Hypothetical Role of CO2 in the Origin of Life." Synlett 30, no. 09 (March 19, 2019): 987–96. http://dx.doi.org/10.1055/s-0037-1611738.

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Carbon dioxide is arguably one of the most stable carbon-based molecules, yet enzymatic carbon fixation processes enabled the sustainable life cycle on Earth. Chemical reactions involving CO2-functionalization often suffer from low efficiency with highly reactive substrates. We recently reported mild carboxylation of aldehydes to furnish α-keto acids – a building block for chiral α-amino acids via reductive amination. Here, we discuss potential reaction mechanisms of aldehyde carboxylation reactions based on two promoters: NHCs and KCN in the carboxylation reaction. New DFT mechanistic studies suggested a lower reaction barrier for a CO2-functionalization step, implying a potential role of CO2 in prebiotic evolution of organic molecules in the primordial soup.1 Introduction: Aldehydes, Benzoins, Carboxylic Acids2 CO2-Activation: NHC, Cyanide, Lewis Acid and Water3 A Breslow Intermediate: Benzoin Reaction vs. Carboxylation with CO2 4 Carboxylation in the Primordial Soup5 Conclusion
10

Gasparetto, Maura, Craig T. Jordan, Mohammad Minhajuddin, Daniel A. Pollyea, Vasilis Vasilou, Philip Reigan, R. Keith Humphries, and Clayton A. Smith. "ALDH Genes and Reactive Aldehydes Play Important Roles in HSCs and Leukemia and May Be Exploited to Treat AML." Blood 122, no. 21 (November 15, 2013): 2893. http://dx.doi.org/10.1182/blood.v122.21.2893.2893.

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Abstract ALDH1A1 is expressed at high levels in normal HSCs and we previously reported that its function might involve metabolism of compounds termed reactive aldehydes. We also reported that loss of ALDH1A1 led to a compensatory increase in a related isoform, ALDH3A1, which also metabolizes reactive aldehydes. Double knockouts for both ALDH1A1/3A1 accumulate reactive aldehydes, which appear to impact a number of cellular processes including signal transduction and gene expression. As reactive aldehydes also cause DNA damage, we hypothesized that excess accumulation of reactive aldehydes may predispose to leukemic transformation of HSCs. In support of this, we found that ALDH1A1/3A1 double knockout HSCs readily form acute leukemia following transduction with a NUP98-HOXA10 fusion gene, which rarely causes leukemic transformation in wild type HSCs. Furthermore, in human AML, frequent absence of ALDH1A1 and the universal absence of ALDH3A1 was observed. A human AML cell line, Kasumi-1, was found to be ALDH1A1/3A1 deficient and to have high levels of intracellular reactive aldehydes. In addition, Kasumi-1 was highly sensitive to DNA damage and cell death following exposure to exogenous 4-HNE, a prototypic reactive aldehyde. In contrast, normal CD34+ HSCs were relatively resistant to 4-HNE. Based on these observations, we further hypothesized that treatment of ALDH1A1/3A1 deficient AMLs with clinically relevant compounds that further increase intracellular 4-HNE levels would selectively eliminate AML while sparing normal CD34+ HSCs. To test this, Kasumi-1 were exposed to a series of compounds including the pro-oxidant Arsenic tri-oxide (ATO), the sesquiterpene lactone parthenolide (PTL) and 4-HC, the active metabolite of cyclophosphamide (Cy) and a substrate of ALDH1A1. All increased intracellular 4-HNE levels and DNA damage. Exposure to combinations of 4-HC, ATO and PTL induced high levels of cell death in Kasumi-1. In contrast, Kasumi-1 cells engineered to express ALDH1A1 through lentiviral gene transfer and normal CD34+ HSCs were relatively resistant to several of these treatments. Primary ALDH1A1/3A1- AMLs were also relatively sensitive to treatment with these same compounds. In conclusion, ALDHs and reactive aldehydes may play important roles in HSCs and leukemia and exploitation of their biology may lead to novel therapies for AML and possibly other cancers. As an initial application of this treatment strategy, we are developing a clinical trial to treat patients with relapsed/refractory ALDH1A1/3A1 deficient AML with Cy/ATO. Disclosures: No relevant conflicts of interest to declare.
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Journal articles Dissertations / Theses

Dissertations / Theses on the topic "Reactive aldehydes":

1

Shirozu, Fumitaka. "Development of Asymmetric Michael Additions of Aldehydes to Reactive Acrylates Using Axially Chiral Secondary Amino Diol Catalysts." 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/175142.

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Näsström, Thomas. "Characterization of α-synuclein oligomers : Implications for Lewy Body Disorders." Doctoral thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160102.

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Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy are disorders featuring accumulation of Lewy bodies in brain. The main component of these large insoluble intracellular inclusions is the presynaptic protein alpha-synuclein (α-synuclein). It is generally believed that α-synuclein monomers adopt an abnormal conformation that favors the formation of soluble oligomers or protofibrils and, eventually, insoluble fibrils depositing as Lewy bodies. Notably, the intermediately sized oligomers/protofibrils seem to have particular neurotoxic effects. Several factors may influence the formation of α-synuclein oligomers/protofibrils, e.g. the reactive aldehydes 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE) formed during oxidative stress. The overall aims of this thesis were to investigate biophysical and biochemical properties of in vitro generated α-synuclein oligomers, characterize their functional effects on cell and animal disease models as well as to explore whether their formation could be prevented in a cell culture model for oligomerization.  Here, it was found that α-synuclein rapidly formed oligomers after incubation with both ONE and HNE. The resulting oligomers were stable and did not continue to form insoluble fibrils. By comparing HNE- and ONE induced α-synuclein oligomers biochemically they were both found to exhibit extensive β-beta sheet structure and had a molecular size of ~2000 kDa. However, they differed in morphology; the ONE induced α-synuclein oligomers described round amorphous species whereas the HNE induced α-synuclein oligomers appeared as elongated protofibril-like structures. Both these oligomers were cell internalized to varying degrees and induced toxicity in neuroblastoma cells. In addition, the ONE induced α-synuclein oligomers seemed to initiate aggregation of monomeric α-synuclein in vitro, but failed to do so in vivo. Finally, treatment of α-synuclein overexpressing cells with monoclonal antibodies specific for α-synuclein significantly reduced aggregation and lowered levels of the protein, suggesting increased turnover in these cells.  To conclude, this thesis has characterized different oligomeric α-synuclein species, which may have properties similar to soluble species central to the pathogenesis of Parkinson’s disease and other disorders with α-synuclein pathology. For therapeutic strategies it is important to selectively target such harmful protein species and avoid interaction with other forms of α-synuclein, which may have vital physiological cellular functions.
3

Fagerqvist, Therese. "Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders." Doctoral thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204466.

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The protein alpha-synuclein (α-synuclein) accumulates in the brain in disorders such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). It is believed that the monomeric form of α-synuclein can adopt a partially folded structure and start to aggregate and form intermediately sized oligomers or protofibrils. The aggregation process can continue with the formation of insoluble fibrils, which are deposited as Lewy bodies. The oligomers/protofibrils have been shown to be toxic to neurons and are therefore believed to be involved in the pathogenesis of the actual diseases.       The overall aims of this thesis were to investigate the properties of α-synuclein oligomers and to generate and characterize antibodies against these species. In addition, the potential for immunotherapy of the α-synuclein oligomer-selective antibodies were evaluated in a transgenic mouse model with α-synuclein pathology. Stable, β-sheet rich α-synuclein oligomers were induced by incubation with either one of the reactive aldehydes 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE). The oligomers exhibited distinct morphological properties, although both types were toxic when added to a neuroblastoma cell line. The seeding effects of ONE-induced oligomers were studied in vitro and in vivo. The oligomers induced seeding of monomeric α-synuclein in a fibrillization assay but not in a cell model or when injected intracerebrally in transgenic mice. It seemed, however, as if the oligomers affected α-synuclein turnover in the cell model. By immunizing mice with HNE-induced oligomers antibody producing hybridomas were generated. Three monoclonal antibodies were found to have strong selectivity for α-synuclein oligomers. These antibodies recognized Lewy body pathology in brains from patients with PD and DLB as well as inclusions in the brain from young α-synuclein transgenic mice, but did not bind to other amyloidogenic proteins. Finally, immunotherapy with one of the oligomer/protofibril selective antibodies resulted in lower levels of such α-synuclein species in the spinal cord of α-synuclein transgenic mice. To conclude, this thesis has focused on characterizing properties of α-synuclein oligomers. In particular, antibodies selectively targeting such neurotoxic forms were generated and evaluated for passive immunization in a transgenic mouse model. Such immunotherapy may represent a future treatment strategy against Lewy body disorders.
4

Esiringu, Ilker. "Intermolecular Addition Of Aldehydes To Ketones Via Acyl Phosphonates." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609441/index.pdf.

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This thesis presents a new developed method for first intermolecular aldehyde/ketone cross benzoin coupling. Protected &
#945
-keto tertiary alcohols are synthesized starting from easily available acyl phosphonates and ketones via Brook rearrangement in the presence of catalytic amount of cyanide ion. The scopes and the limitations of the methods for the synthesis of tertiary alcohols with &
#945
-keto group are discovered.
5

Bronger, Raymond Petrus Johannes. "Selective hydroformylation of internal alkenes to linear aldehydes novel phosphacyclic diphosphines and their applications /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/75911.

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6

PAQUET, PATRICK. "Photochimie laser des aldehydes aliphatiques. Reactivite et addition sur les esters insatures." Nice, 1993. http://www.theses.fr/1993NICE4605.

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Dans notre etude nous examinons le comportement des aldehydes aliphatiques sous irradiation laser pulse nd-yag de frequence triplee. Contrairement a ce qui est observe en photochimie classique, on met en evidence une haute selectivite avec formation quasi exclusive d'alpha-dione et d'alpha-cetol avec un rendement quantique eleve. Les aldehydes s'additionnent, par le radical acyle, sur les esters insatures pour l'obtention de gamma-cetoesters. Le comportement des aldehydes, en fonction de la structure ramifiee, a ete etudie pour cette reaction. Pour les aldehydes non ramifies en alpha de la fonction carbonyle les rendements quantiques sont voisins de 2000% alors qu'une photochimie classique ils n'atteignent que 10%. Sous irradiation laser, on assiste a une reaction en chaine pour laquelle un mecanisme, compatible avec nos resultats experimentaux, est propose, different de celui avance pour la lampe a mercure. On a etabli que le processus d'excitation est monophotonique sous irradiation laser pulse, comme il l'est avec la lampe a mercure. La haute concentration instantanee d'especes actives semble etre a l'origine des differences observees. Nous montrons, dans cette etude, que, par leurs proprietes exceptionnelles, les lasers offrent des possibilites nouvelles en synthese organique photochimique
7

Tourbah, Hiam. "Synthese et reactivite de composes polyfonctionnels a groupement aldehyde masque." Rennes 1, 1986. http://www.theses.fr/1986REN10117.

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Homma, Chihiro. "Development of Amine-Catalyzed Asymmetric Reactions of Aldehydes with Alkynyl Z-Ketimines." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263497.

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Pinar, Ayse Nur. "Reaction Of Propargyl Aldehydes With Hydrazinium Salts: Synthesis Of Ferrocenyl And Phenyl Substituted Pyrazoles." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609769/index.pdf.

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Pyrazoles have been focus of a large number of investigations in the design and synthesis of novel biologically active agents that show remarkable medicinal activities. Although pyrazoles have been studied for over a century as an important class of heterocyclic compounds, they still continue to attract considerable attention due to the wide range of medicinal activities they possess. Recent studies have shown that combination of a ferrocenyl unit with structural features of pyrazoles can lead to products with enhanced or/and unexpected biological activity since several ferrocene derivatives have already been shown to be active against a number of tumors. As a result, we have investigated the reaction of 3-ferrocenylpropynal with hydrazinium salts. As anticipated, these reactions afforded two kinds of pyrazoles, namely 1-alkyl/aryl-5-ferrocenylpyrazoles (1,5-isomer) and 1-alkyl/aryl-3- ferrocenylpyrazoles (1,3-isomer). In most cases, 1,5-pyrazole isomers have resulted from these reactions as the single or the major product of the reactions. The structures of 1-benzyl-5-ferrocenylpyrazole, 1-phenyl-5-ferrocenyl-pyrazole and 1- (2-hydroxy-ethyl)-3-ferrocenylpyrazole were identified by X-ray single crystal analysis. The analogous reactions between 3-phenylpropynal and hydrazinium salts were also studied, which afforded 1-alkyl/aryl-5-phenylpyrazoles (1,5-isomer) and/or v 1-alkyl/aryl-3-phenylpyrazoles (1,3-isomer). The regioselectivity of the reactions is mainly governed by the nature of the substituents in hydrazine derivative.
10

Yalcinkaya, Hatice. "Studies On The Reaction Of Acyl Phosphonates With Aldehydes In The Presence Of Proline." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610359/index.pdf.

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Acyl phosphonates are interesting precursors for the synthesis of biologically active compounds. In the first part, the acyl phosphonates are synthesized starting from the corresponding acyl chloride. The acyl chlorides are converted into acyl phosphonates by using trialkylphosphites. The reaction of acyl phosphonates with aldehydes in the presence of proline furnished not the suggested aldol products via proline catalyzed aldol reaction but bicyclic products via one pot tricomponent 1,3-dipolar cycloaddition reaction. The formation of the bicyclic compound was suggested as followed
The formation of iminium salt of proline with aldehyde followed by decarboxylation furnished azomethine. The 1,3-dipolar cycloaddition of the formed azomethine with carbonyl group of acyl phosphonate afforded substituted hexahydro pyrrolo oxazole structures. 1,3-Dipolar cycloaddition forms the basis of the most preparatively useful procedures for the synthesis of five-membered heterocycles. One example is the 1,3-dipolar cycloaddition of azomethine ylides (from imines) and alkenes, which allows the stereoselective synthesis of pyrrolidines or proline derivatives.
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Books on the topic "Reactive aldehydes":

1

Shi, Min. The chemistry of the Morita-Baylis-Hillman reaction. London: Royal Society of Chemistry, 2011.

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2

Teerawutgulrag, Aphiwat. Asymmetric induction in Lewis acid promoted reaction of some d- and e-(Alkyloxyallyl)stannanes and aldehydes. Manchester: University of Manchester, 1993.

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Bolden, Michael E. Investigation of the tris(2,2'-bipyridine)ruthenium(III) chemiluminescence reaction for the determination of aromatic amines and aldehydes by flow injection or liquid chromatography. 2001.

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Calvert, Jack, Abdelwahid Mellouki, John Orlando, Michael Pilling, and Timothy Wallington. Mechanisms of Atmospheric Oxidation of the Oxygenates. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199767076.001.0001.

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Prepared by an international team of eminent atmospheric scientists, Mechanisms of Atmospheric Oxidation of the Oxygenates is an authoritative source of information on the role of oxygenates in the chemistry of the atmosphere. The oxygenates, including the many different alcohols, ethers, aldehydes, ketones, acids, esters, and nitrogen-atom containing oxygenates, are of special interest today due to their increased use as alternative fuels and fuel additives. This book describes the physical properties of oxygenates, as well as the chemical and photochemical parameters that determine their reaction pathways in the atmosphere. Quantitative descriptions of the pathways of the oxygenates from release or formation in the atmosphere to final products are provided, as is a comprehensive review and evaluation of the extensive kinetic literature on the atmospheric chemistry of the different oxygenates and their many halogen-atom substituted analogues. This book will be of interest to modelers of atmospheric chemistry, environmental scientists and engineers, and air quality planning agencies as a useful input for development of realistic modules designed to simulate the atmospheric chemistry of the oxygenates, their major oxidation products, and their influence on ozone and other trace gases within the troposhere.

Book chapters on the topic "Reactive aldehydes":

1

Schauenstein, E., and H. Esterbauer. "Formation and Properties of Reactive Aldehydes." In Novartis Foundation Symposia, 225–44. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720493.ch15.

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Carini, Marina, Giancarlo Aldini, and Roberto Maffei Facino. "Sequestering Agents of Intermediate Reactive Aldehydes as Inhibitors of Advanced Lipoxidation End-Products (ALEs)." In Redox Proteomics, 877–929. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/0471973122.ch27.

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Li, Jie Jack. "Reissert reaction (aldehyde synthesis)." In Name Reactions, 303–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_238.

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Li, Jie Jack. "Reissert reaction (aldehyde synthesis)." In Name Reactions, 334–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_249.

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Murray, B. A. "Reactions of Aldehydes and Ketones and their Derivatives." In Organic Reaction Mechanisms · 2014, 1–85. Chichester, UK: John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781118941829.ch1.

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Murray, B. A. "Reactions of Aldehydes and Ketones and their Derivatives." In Organic Reaction Mechanisms · 2006, 1–51. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470669587.ch1.

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Knipe, A. C. "Reactions of Aldehydes and Ketones and their Derivatives." In Organic Reaction Mechanisms · 2008, 1–44. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470979525.ch1.

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Murray, B. A. "Reactions of Aldehydes and Ketones and their Derivatives." In Organic Reaction Mechanisms Series, 1–66. Chichester, UK: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118560273.ch1.

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Murray, B. A. "Reactions of Aldehydes and Ketones and their Derivatives." In Organic Reaction Mechanisms Series, 1–73. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119972471.ch1.

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Murray, B. A. "Reactions of Aldehydes and Ketones and their Derivatives." In Organic Reaction Mechanisms Series, 1–54. Chichester, UK: John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119941910.ch1.

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Conference papers on the topic "Reactive aldehydes":

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Jones, Caleb W. "Reactive Aldehydes As Mediators Of Pulmonary Inflammation." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2732.

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Pavri, Roointon E., and Richard A. Symonds. "Unburned Hydrocarbon, Volatile Organic Compound, and Aldehyde Emissions From General Electric Heavy-Duty Gas Turbines." In ASME 1990 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1990. http://dx.doi.org/10.1115/90-gt-279.

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Field data clearly show that the emissions of UHC, VOC, (sometimes also called Reactive Organic Gases), and Aldehydes from GE heavy-duty gas turbines are very low. At loads exceeding 75% of base, these emissions are less than 2 ppm. In fact, stack emissions are often less than background concentration. Proper methods of measurement and quality assurance are necessary to detect and measure such low values. Allowance for background hydrocarbons should be made when guaranteeing UHC/VOC.
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Fleisher, M., D. Jansone, and L. Leite. "Nucleophilic Addition Reaction of Unsaturated Methyl Lactones with Pyridine Aldehydes." In The 1st International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02001.

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Barari, Ghazal, Batikan Koroglu, Artëm E. Masunov, and Subith Vasu. "Combustion of Aldehydes in the Negative Temperature Coefficient Region: Products and Pathways." In ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/gt2016-58025.

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Aldehydes are major intermediates in oxidation and pyrolysis of hydrocarbons and particularly biofuels. While the high temperature oxidation chemistry of C3-C5 aldehydes have been studied in the literature, a comprehensive low temperature kinetics remains unaddressed. In this work, acetaldehyde, propanal, and 2-propenal (acrolein) oxidation was investigated at low-temperature combustion condition (500–700 K). The isomer specific products concentrations as well as the time-resolved profiles were studied using Sandia’s multiplexed photoionization mass spectroscopy (MPIMS) with synchrotron radiation from the Advanced Light Source (ALS). The laser pulsed photolysis generates chlorine atoms which react with aldehydes to form the parent radicals. In the presence of excess oxygen, these radicals react with O2 and form RO2 radicals. The temperature dependent products yields are determined for 500 K to 700 K and the competition between the channels contributing to the formation of each product is discussed. In acetaldehyde oxidation, the formation of the main products are associated with HO2 elimination channel from QOOH or direct H atom elimination from the parent radicals. In propanal oxidation, the most intensive signal peak was associated with acetaldehyde (m/z=44) which was formed through the reaction of α′-R with O2. α′-RO2 intermediate decomposes to acetaldehyde+OH+CO via Waddington mechanism and formation of five-member ring transition state. In 2-propenal oxidation, the unsaturated radical produced from α-R reacts with O2 to form the primary products.
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Li, Guigen, Han-Xun Wei, and Subramanian Karur. "Halo Aldol Reaction of a,b-Unsaturated Ketones and Aldehydes Mediated by Titanium Tetrachloride." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01838.

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Kumar, Anand, and Anchu Ashok. "Catalytic Decomposition of Ethanol over Bimetallic Nico Catalysts for Carbon Nanotube Synthesis." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0039.

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In this work we investigate the use of NiCo bimetal/oxide as catalyst for hydrogen production from ethanol, with a focus on the deactivation pattern and the nature of the observed carbon deposition. It is well known that sintering and coke deposition during decomposition reaction significantly reduces the activity of the catalysts at higher temperature, by blocking the active sites of the catalysts. During ethanol decomposition reaction, the cleavage of C-C bond produces adsorbed *CH4 and *CO species that further decompose to form carbonaceous compounds. FTIR in-situ analysis was conducted between 50 to 400°C for all the catalysts to understand the reaction mechanism and product selectivity. Cobalt was found to be selective for aldehyde and acetate, whereas bimetallic Ni-Co was selective for the formation of CO at 400°C along with aldehyde. Complete conversion of ethanol was observed at 350°C and 420°C for NiCo and Cobalt respectively indicating an improvement in the rate of conversion when Ni was added to cobalt. The crystallinity, morphology and particle analysis of the used catalyst after reaction were studied using XRD, SEM and TEM respectively. The XRD shows the complete phase change of porous NiCoO2 to NiCo alloy and SEM indicates the presence of fibrous structure on the surface with 91.7 % of carbon while keeping 1:1 ratio of Ni and Co after the reaction. The detailed analysis of carbon structure using HRTEM-STEM shows the simultaneous growth of carbon nano fibers (CNFs) and multiwalled carbon nanotubes (MWCNTs) that were favored on larger and smaller crystallites respectively. Analysis of carbon formation on individual Co catalyst and bimetallic NiCo catalyst shows a clear difference in the initiation pattern of carbon deposition. Metallic Co nanoparticles were found to be more mobile where Co disperses along the catalysts surface, whereas NiCo nanoparticles were relatively less mobile, and maintained their structure.
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Elsalem, L., S. Allison, R. Phillips, and K. Pors. "PO-273 Aldehyde dehydrogenase 7A1 (ALDH7A1) contributes to reduction of reactive oxygen species generation in colorectal tumour microenvironment." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.787.

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Dekamin, Mohammad, and Zahra Mokhtari. "Highly Efficient Three-Component Strecker-Type Reaction of Aldehydes and Ketones Using TMSCN Catatalyzed by Recyclable and Heterogeneous Mesoporous B-MCM-41." In The 14th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00412.

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Jenkins, Alyn, Santosh Gopi, Jody Hoshowski, Warinthon Lertpornsuksawat, Jennifer Jackson, and Thomas Wilson. "Application of a New H2S Scavenger with Improved Performance in The Field." In SPE Annual Technical Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/206057-ms.

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The presence of hydrogen sulfide (H2S) gas occurs naturally, or can be introduced via bacteria contamination, in oil and gas reservoirs worldwide. There are several options for the removal of H2S from produced oil and gas ranging from fixed assets that scrub H2S to chemical injection at the wellsite. The area of interest for many operators is in the continuous application of non-reversible chemical H2S scavengers as an easy, reliable and cost-effective solution. The majority of the non-reversible chemical H2S scavenger market is based on triazine technology derived from the reaction products of formaldehyde and amines. In recent past, there has been an active industry wide search to improve the overall performance of H2S scavengers. Major topics for improvement include: Increased H2S scavenging capacityReduction of nitrogen contamination of crude oilReduction of scale formationElimination of by-product depositionAddressing existing environmental, health and safety concernsMinimization of products/reaction by-products disposal Conversely, some of the biggest hurdles with new H2S scavengers are ensuring fast kinetic reaction rates, system compatibility, consumption rates, minimal precipitation of scavenger/by-products, scalable manufacturing and competitive economics. Many new products have been proposed by chemical manufactures but often are not able to deliver enough benefits to warrant a change from the industry standard triazine. One potential solution is to pull through a technology from a different industry that already has established production, in significant volumes, for use in oilfield applications. Ideally, the new product would offer better performance versus the incumbent, a reduction in nitrogen content and minimize solids formation and deposition. A product identified several years ago as a potential replacement was an oxazolidine derivative referred to as MBO (3,3’-methylenebis(5-methyloxazolidine)). However, MBO has had limited application in the field until recently. MBO offers some of the same benefits as triazine but outperforms the incumbent technology by increasing the consumption of H2S per mole of scavenger, reducing the nitrogen content in crude oil, reducing the by-product deposition potential. Moreover, MBO is already produced in large manufacturing quantities. In this paper we will discuss details about the chemistry and increased formaldehyde content, laboratory results related to performance, system compatibilities, decreased transportation cost and confirmation of field application on large scale that supports the usage of this alternative H2S scavenger to standard triazine. H2S scavengers are used to mitigate the risks presented by H2S. They react with H2S in the liquid phase to form non-hazardous, non-reactive species that are often water soluble and thus disposed with water. Monoethanolamine (MEA) triazine (hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine) is the most widely used scavenger. It is less toxic than most aldehyde scavengers and reacts very quickly with H2S. MEA triazine reacts irreversibly with H2S to form dithiazine (5-hydroxyethylhexahydrodithiazine). One of the major concerns with MEA triazine is that there is a strong possibility of the by-product MEA reacting with excess H2S to form an ethanolammonium sulfide species that in turn reacts with the dithiazine to form a largely insoluble polymer, commonly referred to as amorphous dithiazine. An alternative triazine used in oil and gas production is monomethylamine (MMA) triazine (1,3,5-trimethyl hexahydro-s-triazine). MMA triazine has greater volatility than MEA triazine so is more suitable for dry gas applications. In the cases on MEA triazine and MMA triazine the ratio to amine:formaldehyde is 1:1.
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Larm, O., L. Adolfsson, I. Gouda, A. Malmberg, P. Olsson, and E. Scholander. "AN IMPROVED METHOD FOR COVALENT IMMOBILISATION OF HEPARIN BY END POINT ATTACHMENT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643090.

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When creating a non-thrombogenic surface by immobilisation of heparin, most of the biological activity of heparin as it is expressed in blood should be retained after the coupling procedure. Consequently the chemical methods used in the immobilisation procedure shall be selected so that they do not, infavorably, affect the anti-thrombin (AT) binding site, the charge distribution and charge density of heparin.To ascertain that the AT-binding sequence is not involved in the coupling procedure, we have developed a method in which heparin is coupled by end point attachment (EPA). Heparin is partially degraded with nitrous acid and fragments with reactive aldehydo functions in the reducing terminal residues are formed. These are coupled to aminated surfaces by reductive amination. The primary amines have been introduced on the substrates in different ways, depending on their hydrophobic or hydrophilic characteristics.It has been possible to furnish such complex devices as hollow fibre oxygenators, tubing sets and cannulas with the heparin surface. Heparinized oxygenators have successfully been used in vivo and clinically without and/or with limited systemic heparinization.

Reports on the topic "Reactive aldehydes":

1

Broekhuis, R. R., S. Lynn, and C. J. King. Recovery of propylene glycol from dilute aqueous solutions via reversible reaction with aldehydes. Office of Scientific and Technical Information (OSTI), December 1993. http://dx.doi.org/10.2172/10129183.

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Joshi, Navalkishore N., Chongsuh Pyun, Verinder K. Mahindroo, Bakthan Singaram, and Herbert C. Brown. Chiral Synthesis via Organoboranes. 33. The Controlled Reaction of B- Alkydiisopinocampheylboranes with Aldehydes Providing a Convenient Procedure for the Enantiomeric Enrichment of the Boronic Ester Products Through Kinetic Resolution. Fort Belvoir, VA: Defense Technical Information Center, June 1991. http://dx.doi.org/10.21236/ada238257.

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