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Relevant bibliographies by topics / Reactive oxigen species (ROS)

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Dissertations / Theses

Academic literature on the topic 'Reactive oxigen species (ROS)'

Author: Grafiati

Published: 9 March 2023

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Dissertations / Theses on the topic "Reactive oxigen species (ROS)"

1

Ristic, Marko. "ROS/SUMO relationship in the chemotherapeutic treatment of Acute Myeloid Leukemia." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT047.

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Les leucémies aiguë myéloïde (LAM) sont un groupe d’hémopathies malignes, dont le traitement est généralement composé de deux génotoxiques : la cytarabine (Ara-C) et la daunorubicine (DNR). Nous avons montré que l’Ara-C et la DNR induisent la déconjugaison rapide de SUMO (Small Ubiquitin-related Modifier) de ses protéines cibles. Cette deSUMOylation est dûe à l'inactivation des enzymes E1 et E2 de SUMOylation par les espèces réactives de l'oxygène (ROS) produites par l’Ara-C et la DNR et est impliquée dans l'activation de l'apoptose. En outre, cet axe ROS/SUMO est anergisé dans les LAM chimior

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2

Menazza, Sara. "Relationship between mitochondrial ROS formation and myofibrillar protein oxidation in contractile dysfunction." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421607.

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Oxidative stress has been related in numerous cardiovascular and muscular pathologies, but the causal relationship between ROS accumulation and contractile impairment is not clear yet. We hypothesized that upon oxidative stress myofibrillar proteins (MPs) are oxidized providing a relevant contribution to the decrease of contractile performance. The evidence provided in the present work demonstrates the key role of mitochondrial dysfunction in muscle injury. We demonstrated that ROS produced in mitochondria alter MPs causing contractile dysfunction in cardiac and skeletal muscle. These results

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3

Hirst, Suzanne Marie. "Anti-inflammatory Effects and Biodistribution of Cerium Oxide Nanoparticles." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/76806.

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Cerium oxide nanoparticles have the unique ability to accept and donate electrons, making them powerful antioxidants. Their redox nature is due to oxygen defects in the lattice structure, which are more abundant at the nanoscale. Reactive oxygen species (ROS) are pro-oxidants whose presence is increased during periods of inflammation in the body. ROS damage tissues and cellular function by stripping electrons from proteins, lipids, and DNA. We investigated the ability of nanoceria to quench ROS in vitro and in vivo, and examined the biodistribution and biocompatibility of nanoceria in murine m

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4

Wason, Melissa. "Cerium Oxide Nanoparticles Sensitize Pancreatic Cancer Cells to Radiation by Promoting Acidic pH, ROS, and JNK Dependent Apoptosis." Doctoral diss., University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6033.

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Side effects of radiation therapy (RT) remain the most challenging issue for pancreatic cancer treatment. In this report we determined whether and how cerium oxide nanoparticles (CONPs) sensitize pancreatic cancer cells to RT. CONP pretreatment enhanced radiation-induced reactive oxygen species (ROS) production preferentially in acidic cell-free solutions as well as acidic human pancreatic cancer cells. In acidic environments, CONPs favor the scavenging of superoxide radical over the hydroxyl peroxide resulting in accumulation of the latter whereas in neutral pH CONPs scavenge both. CONP treat

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5

Barreiro, Portela Esther. "Study of reactive oxygen species (ROS) and nitric oxide (NO) as molecular mediators of the sepsis-induced diaphragmatic contractile dysfunction : protective effect of heme oxygenases." Doctoral thesis, Universitat Pompeu Fabra, 2002. http://hdl.handle.net/10803/7066.

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Protein nitration is considered as a marker of reactive nitrogen species formation. Heme oxygenases (HOs) are important for the defence against oxidative stress. We evaluated the involvement of the neuronal (nNOS), the endothelial (eNOS), and the inducible (iNOS) in nitrotyrosine formation and localitzation, and both the expression and funcional significance (HO inhibition and contractility studies) of HOs in sepsis-induced muscle contractile dysfunction. Sepsis was elicited by injecting rats and transgenic mice deficient in either nNOS, eNOS, or iNOS isoforms with E.Coli lipolysaccharide (LPS

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6

Viegas, Juliane Oliveira. "Cytotoxic potential of graphene oxide in human lung Adenocarcinoma cell line." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/22356.

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Mestrado em Biologia Molecular e Celular<br>Graphene oxide (GO) is a compound with application in several fields, especially biomedicine and environment, due to its unique properties which confer excellent characteristics. Despite the nowadays wide application of nanomaterials, the lack of information regarding the risks to human health and the environment is still remaining. Consequently, the investigation about the toxicity of nanoparticles must be a priority. The lung is one of the main routes of entry for nanoparticles into the body, therefore, the aim of this study is to evaluate the cyto

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7

Garlid, Anders Olav. "Mitochondrial Reactive Oxygen Species (ROS): Which ROS is Responsible for Cardioprotective Signaling?" PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/1641.

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Mitochondria are the major effectors of cardioprotection by procedures that open the mitochondrial ATP-sensitive potassium channel (mitoKATP), including ischemic and pharmacological preconditioning. MitoKATP opening leads to increased reactive oxygen species (ROS), which then activate a mitoKATP-associated PKCε, which phosphorylates mitoKATP and leaves it in a persistent open state (Costa, ADT and Garlid, KD. Am J Physiol 295, H874-82, 2008). Superoxide (O2•-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•) have each been proposed as the signaling ROS but the identity of the ROS responsi

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8

Vaidyanathan, V. V. "Oxidative Stress In The Brain: Effects Of Hydroperoxides And Nitric Oxide On Glyceraldehyde 3-Phosphate Dehydrogenase And Phosphoinositide Cycle Enzymes." Thesis, Indian Institute of Science, 1994. http://hdl.handle.net/2005/142.

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In the aerobic cell, oxygen can be converted into a series of reactive metabolites, together called as "reactive oxygen species" (ROS). This large group include both radical and non-radical species such as superoxide anion (02"), hydroxyl radical ("0H), H202, nitric oxide (N0') and lipid hydroperoxides (LOOH). ROS are generated in very small amounts at all stages of aerobic life, and probably have a role in cellular regulation. However, their formation in excess leads to toxicity and damage to tissues. This situation, called 'oxidative stress', is responsible, atleast in part, to the pathophys

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9

Al-Nu'airat, Jomana. "Implications of reactive oxygen species (ROS) in initiating chemical reactions." Thesis, Al-Nu'airat, Jomana (2018) Implications of reactive oxygen species (ROS) in initiating chemical reactions. PhD thesis, Murdoch University, 2018. https://researchrepository.murdoch.edu.au/id/eprint/42916/.

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This thesis presents a series of scientific studies exploring the initiation of various chemical reactions with reactive oxygen species (ROS), mainly singlet oxygen. These studies have revealed new mechanistic insights in environmental, industrial and biological systems, have described the associated set of reactions, have illustrated the detection of new radicals i.e., environmentally persistent free radicals (EPFR), and have provided a new insight explaining the spontaneous fire in coal mines. Comprehensive experimental and quantum-mechanical calculations afforded the investigation of oxidat

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10

Todd, Adam. "The role and inhibition of reactive oxygen species (ROS) in psoriasis." Thesis, University of Sunderland, 2009. http://sure.sunderland.ac.uk/3699/.

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Psoriasis is a chronic inflammatory skin disorder that affects around two percent of the population. There are many treatments available for the management of psoriasis including topical therapy, systemic agents and phototherapy. Despite the number of treatments available, however, there are still problems in the management of psoriasis. It is suggested here that the thioredoxin enzyme system may play a role in the pathology of psoriasis. Using specific molecular modelling techniques, a lead compound, RDP00060, was identified as a potential inhibitor of thioredoxin reductase, a key enzyme in t

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