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Dissertations / Theses on the topic 'Reactive Oxygen Species Generation'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Fisher, Helen M. "Mechanisms of reactive oxygen species generation by mammalian spermatozoa." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20503.

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The generation of reactive oxygen species (ROS) is an activity normally associated with phagocytic leucocytes, which employ an enzymatic complex, the NADPH oxidase, to catalyze the univalent reduction of molecular oxygen to superoxide. However, it is now apparent that many other cell types, including mammalian spermatozoa, generate ROS. ROS have been implicated in peroxidative damage associated male sub-fertility, and also more recently, in the regulation of normal sperm function. With the obvious biological importance of ROS generation by spermatozoa in mind, the aims of this PhD have been to

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2

Giurnazi, Ali Mansour. "Involvement of reactive oxygen species generation in cellular and subcellular fractions." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318298.

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3

ANCONA, ANDREA. "Ultrasound-induced Reactive Oxygen Species generation by Zinc Oxide Nanostructures: Mechanisms and Applications." Doctoral thesis, Politecnico di Torino, 2020. http://hdl.handle.net/11583/2823940.

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4

Lavado, Andrea Sofia Caetano das Neves. "Porphyrinic-nanoplatforms : controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14200/.

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Reactive Oxygen Species (ROS) are known as important intracellular signaling molecules. These are also well known for their role in oxidative stress and cellular damage, leading to their involvement in several pathologies. Despite the widespread postulation of ROS mechanisms, little is actually known about the immediate response in living cells to the generation of these highly reactive compounds. The development of nanoplatforms incorporating photosensitizers would permit the generation of ROS at specific sub-cellular locations and determine the in situ cellular response. The work presented i

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5

Mishra, A. "Biochemical studies on reactive oxygen species generation and its physiological role in mycobacterium sp." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2012. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2134.

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6

Ash, Catherine Elizabeth. "Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494167.

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Dietary restriction (DR) across a wide phylogenetic range increases both mean and maximal lifespan by retarding the ageing process and delaying the onset and incidence of age-related pathologies. DR animals exhibit reduced tissue oxidative damage but anti-oxidant enzyme activities and other defence mechanisms against reactive oxygen species (ROS) are not consistently upregulated In such animals. As an alternative explanation ROS generation was Studied in isolated mitochondria from tissues of DR rats. About 90% of cellular ROS generation is thought to result from the single electron transfer to

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7

Schroeter, Sandra. "Reactive oxygen and hydrogen species generation in radio-frequency atmospheric pressure plasmas : experimental and numerical investigations." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/18738/.

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Atmospheric pressure plasmas (APPs) are known to be effective sources for reactive oxygen and nitrogen species (RS), making them potentially suitable for applications in biomedicine, where these species are believed to play a crucial role. However, in order to fully establish plasma sources in biomedicine, detailed characterisation of the RS produced is required. This is particularly challenging at atmospheric pressure, because of high collision rates among particles leading to fast de-excitation of excited states (quenching), complex gas mixing, and the small physical dimensions of the invest

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8

Hargreaves, Aspasia. "Biological sensitizers of near UV : generation of reactive oxygen species and damage to cellular components and microbes." Thesis, Nottingham Trent University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366086.

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9

Hoffman, Marjorie A. "Generation of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically relevant conditions." Thesis, University of Missouri - Columbia, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10180877.

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<p> Hydrogen sulfide (H<sub>2</sub>S) is more commonly known for its toxic properties; however, recently, there has been evidence that this small, gaseous molecule could serve as an endogenous cell-signaling agent. Surprisingly, a number of studies have also provided evidence that H<sub> 2</sub>S is a DNA-damaging mutagen. Using a plasmid-based DNA strand cleavage assay, we examined the chemical mechanisms of DNA damage by H<sub>2</sub>S. We found single-strand DNA cleavage was caused by micromolar concentrations of H<sub>2</sub>S. The mechanistic process was studied and was shown to involve t

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10

Mai, Trang. "FUNCTIONALIZATION OF IRON OXIDE NANOPARTICLES AND THE IMPACT ON SURFACE REACTIVE OXYGEN SPECIES GENERATION FOR POTENTIAL BIOMEDICAL AND ENVIRONMENTAL APPLICATIONS." UKnowledge, 2019. https://uknowledge.uky.edu/cme_etds/102.

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Iron oxide nanoparticles (IONPs) have been widely studied for a variety of applications, from biomedical applications (e.g., cell separation, drug delivery, contrast agent for magnetic resonance imaging and magnetically mediated energy delivery for cancer treatment) to environmental remediations (e.g., heavy metal removal and organic pollutants degradation). It has been demonstrated that IONPs can induce the production of reactive oxygen species (ROS) via Fenton/Haber-Weiss reactions which has been shown to be one of the key underlying mechanisms of nanoparticles toxicity. This inherent toxici

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11

Lucas, Stephen Marc. "Valproic Acid Leads to an Increase in ROS Generation by Inhibiting the Deacetylation of Mitochondrial SOD." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/9247.

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Valproic Acid Promotes Acetylation of Superoxide Dismutase-2 During Neurogenesis. Valproic acid (VPA) is a known developmental toxicant associated with a high prevalence of neural tube defects (NTD). The mechanism of VPA-induced NTD is unclear, but oxidative stress may be implicated. To understand how embryotoxic oxidative stress may occur, we measured superoxide dismutase (SOD) activity following VPA treatment in the embryonic pluripotent P19 mouse carcinoma cell line. In undifferentiated P19 cultures treated with VPA (5 mM), dichlorofluorescein fluorescence increased 15% compared to untreate

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12

Cheng, Yubo. "Reactive oxygen species generation and gene expression linked to sources of atmospheric fine particulate matter (PM₂.₅) in Hong Kong." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/662.

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Fine particulate matter (PM2.5) is the leading public health risk factor of global disease burden, which has caused 4.2 million deaths in 2015. This thesis aims to improve the scientific understanding on the sources and health impacts of PM2.5 in Hong Kong. Various chemical and biological analytical techniques were applied to characterize the chemical and toxicological properties of PM2.5 samples collected in Hong Kong during 2011-2012. Positive matrix factorization (PMF), together with the quantified chemical markers and water-soluble PM2.5-induced reactive oxygen species (ROS) activity as th

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13

Pond, Bethany Leigh. "Effects of flow on reactive oxygen species production in brain versus aortic endothelial cells| The source of ROS generation." Thesis, State University of New York at Buffalo, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1600812.

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<p> Endothelial cells are a vital region in the pathophysiology of the vasculature because it is the interface between blood flow and the vessel. One way that the structure of the vessels wall can change is by the accumulation of reactive oxygen species (ROS), which has been correlated to aneurysm formation. Four main ROS sources in endothelial cells are: NADPH oxidase, mitochondria electron transport chain, eNOS uncoupling, and xanthine oxidase. Endothelial cells are an essential component of vasculature that has distinct functions and morphology. The aorta and brain arteries are highly popul

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14

Sommani, Piyanart. "Study on the modulation of reactive oxygen species generation in cellular systems and its effects on some biologically significant events." Kyoto University, 2007. http://hdl.handle.net/2433/135575.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(エネルギー科学)<br>甲第13404号<br>エネ博第161号<br>新制||エネ||38(附属図書館)<br>UT51-2007-Q805<br>京都大学大学院エネルギー科学研究科エネルギー社会・環境科学専攻<br>(主査)教授牧野圭祐, 教授吉川暹, 准教授小瀧努<br>学位規則第4条第1項該当

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15

Bresolí, Obach Roger. "Novel strategies for singlet molecular oxygen O2(1Δg) generation and detection in cells". Doctoral thesis, Universitat Ramon Llull, 2018. http://hdl.handle.net/10803/662972.

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En aquesta tesi s'han utilitzat diferents estratègies per obtenir control en la producció i detecció de diferents espècies reactives d'oxigen (ROS), especialment per a l'oxigen singlet (1O2). En la primera part de la tesi, l'enfoc principal consisteix en entendre la generació de ROS i intentar potenciar-ne el seu efecte. En primer lloc, demostrem que la modificació de diferents fotosensibilitzadors afegint-hi un catió de trifenilfosfoni com a element diana produeix derivats amb una excel·lent activitat fotoantimicrobiana contra bacteris Gram-positius (S. aureus i E. faecalis). En segon lloc,

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16

Tsang, Shui Ying. "The role of copper and copper-ligand interactions in the generation of reactive oxygen species and the promotion of biomolecular damage." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319216.

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The work described in this thesis investigates the mechanisms by which copper complexes catalyse the generation of reactive oxygen species (ROS), including the highly reactive hydroxyl radical (.OH), and induce oxidative damage to DNA. An ESR study into the copper-Fenton reaction revealed that, in the presence of buffers and other copper chelators, .OH is generated. In contrast, it is suggested that a Cu(III) species may be formed in the reaction of aqueous, unchelated copper ions. The generation of .OH in the copper-Fenton reaction, under biomimetic conditions, was confirmed by analysis of th

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17

Kanczler, Janos Michael. "The role of the reactive oxygen species-generating enzyme, xanthine oxidoreductase, in cytokine- and hormone-induced bone resorption." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311172.

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18

Cedergren, Jan. "Radical aspects on arthritis : the role of neutrophil generation of nitric oxide and superoxide in inflammatory conditions." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med984s.pdf.

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19

Michelini, Luiz Guilherme Bueno 1983. "Caracterização do estímulo da produção mitocondrial de H2O2 por inibição parcial do Complexo I da cadeia respiratória = Stimulatory effects of a partial respiratory Complex I inhibition on mitochondrial H2O2 generation." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313031.

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Orientador: Roger Frigério Castilho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-24T17:18:02Z (GMT). No. of bitstreams: 1 Michelini_LuizGuilhermeBueno_M.pdf: 1602537 bytes, checksum: f58032fd3eaf359e8f094658a3612c02 (MD5) Previous issue date: 2014<br>Resumo: A inibição parcial do Complexo I da cadeia respiratória mitocondrial em ratos tratados cronicamente com rotenona está associada com o desenvolvimento de características neuroquímicas, comportamentais e neuropatológicas da doença de Parkinson. Os objeti

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20

Smith, Cheryl. "Reactive oxygen species in atherosclerosis." Thesis, King's College London (University of London), 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302549.

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21

Stanczak, Anna. "Reactive oxygen species in laundry applications." Thesis, Durham University, 2018. http://etheses.dur.ac.uk/12885/.

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Chapter 1 is divided into two parts, the first gives a brief review of oxygen-based bleaching agents commonly used in powder laundry detergent with emphasis on the properties of hydrogen peroxide and peroxy acids. In the second part of the literature review, different methods of detection of Reactive Oxygen Species (ROS) are discussed. Chapter 2 discusses analytical techniques used throughout this thesis, mainly focusing on the fluorescence and UV-Vis spectroscopy, as well as imaging techniques: Image Analysis and Diffuse Reflectance Spectroscopy. This chapter provides also detailed experiment

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22

Wu, Wan Man. "Reactive oxygen species and murine malaria." Thesis, The University of Sydney, 1992. https://hdl.handle.net/2123/26446.

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The aim of this study was to investigate the role of ROS in the protective and pathological immune response during malarial infection. For this purpose, four isolates of Plasmodium parasites (P. berghei ANKA, P. vinckei, P. berghei K152 and P. chabaudi) and two different inbred strains of mice (CBA and DBA) were used. The patterns of mortality varied between the different mouseparasite strain combinatio ns. The mortality of CBA mice infected with P. vinckei and P. berghei K152, and DBA mice infected with P. berghei ANKA, related to the levels of parasitaemia. However early mortality of CBA

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23

Yu, Tian-Wei. "Genotoxic damage induced by reactive oxygen species." Thesis, University of Surrey, 1997. http://epubs.surrey.ac.uk/764/.

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24

Baumber, Julie. "Reactive oxygen species and equine sperm function /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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25

Xie, Ruiyu. "Reactive Oxygen Species-Induced Necrotic Cell Death." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195215.

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Mechanisms of cell death extend beyond the simple apoptosis/necrosis relationship to include regulated modes of cell death that do not readily fit either of the classic descriptors. One such mechanism of cell death involves poly(ADP-ribose)polymerase-1 (PARP-1)-mediated cell death. 2,3,5-Tris(Glutathion-S-yl)-hydroquinone (TGHQ), a reactive oxygen species (ROS) generating nephrotoxic and nephrocarcinogenic metabolite of hydroquinone, causes necrotic renal cell death, the basis for which is unclear. We therefore investigated TGHQ-mediated cell death in human renal proximal tubule epithelial HK-

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26

Cowgill, Danielle Lee. "FIELD DECTION DEVICE OF REACTIVE OXYGEN SPECIES." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1107.

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Traumatic brain injuries (TBIs) contribute to approximately 30.5% of all injury related deaths in the United States per year and approximately 1.7 million TBIs per year occur as an isolated injury or other injury. Military personnel are exposed to TBIs and have less availability to resources traditionally used to diagnose a TBI. Reactive oxygen species (ROS) play a large role in secondary traumatic brain damage, especially lipid peroxidation, following TBIs. One of the principle and most studied byproducts of lipid peroxidation is malondialdehyde (MDA). The focus of this paper was to create an

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27

Yamamoto, Shinichiro. "Reactive Oxygen Species / Reactive Nitrogen Species-sensitive TRP channels : Molecular Activation Mechanism and Physiological Significance." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/124503.

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28

Liu, Bin. "P53 AND REACTIVE OXYGEN SPECIES: A CONVOLUTED STORY." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_theses/450.

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The tumor suppressor p53 has a close relation with reactive oxygen species (ROS). As an indispensable component of the cellular redox system, ROS not only have been established to be involved in p53-dependent apoptosis, but also regulate p53 activity. Recent studies revealed several novel actions of p53, such as transactivation of antioxidative proteins, mitochondria translocation and inhibition of glycolysis. The fate of cells where p53 signaling pathways are initiated is either survival or death. In this review, we examine the hypothesis that ROS regulate cell fate through p53, in a way that

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29

Lloyd, Daniel Robert. "Formation of DNA damage by reactive oxygen species." Thesis, Institute of Cancer Research (University Of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298187.

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30

Mian, Kousar Bashir. "Inhibition of nitric oxide by reactive oxygen species." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318114.

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31

Pinto, Ana Filipa Carapinha. "Reductive scavenging of reactive oxygen species in prokaryotes." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2012. http://hdl.handle.net/10362/9918.

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Dissertação para a obtenção de grau de doutor em Bioquímica pelo Instituto de Tecnologia Química e Biológica. Universidade Nova de Lisboa.<br>The purpose of this thesis is to contribute to a better understanding of systems involved in the scavenging of reactive oxygen species. The work focuses on an enzyme from the Rubrerythrin family that reduces hydrogen peroxide and one from the Superoxide Reductase family that reduces the superoxide anion. Both of these families are distributed widely across the three domains of life, Archaea, Bacteria and Eukarya, but are mainly found in anaerobic a

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32

Bustami, Mona Ratib. "Reactive oxygen and nitrogen species in cystic fibrosis." Thesis, University of Bath, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248100.

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33

Sun, Zhenning. "Studies on fluorescent probes for the specific detection of reactive oxygen species and reactive nitrogen species in living cells." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36845395.

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34

Hole, Paul Spencer. "Role of reactive oxygen species in ras-mediated leukaemogenesis." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54355/.

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Mutations of Ras and activation of the Ras pathway are amongst the most common abnormalities detected in human cancer (-20%), and in myeloid neoplasia. In addition, excessive production of reactive oxygen species (ROS) is a common feature of human malignancy and is often triggered by activation of Ras oncogenes. ROS act as second messengers and can influence a variety of cellular process including growth factor responses and cell survival. This study examined the contribution of ROS production to the phenotype of mutationally-activated Ras in normal human CD34+ haematopoietic progenitor cells.

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35

Hurd, T. R. "Interactions between mitochondrial protein thiols and reactive oxygen species." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604824.

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This work investigates the reactions of proteins with ROS when mitochondria are exposed to H<sub>2</sub>O<sub>2</sub> or when they generate ROS endogenously. Using isolated mitochondria, those proteins that are particularly sensitive to low concentrations of H<sub>2</sub>O<sub>2</sub> and to ROS generated by the mitochondrial electron transport chain were first identified using a method called Redox-Difference Gel Electrophoresis (Redox-DIGE). Most redox sensitive thiol proteins identified by Redox-DIGE were involved either in fatty acid oxidation or in the regulation of the pyruvate dehydroge

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36

Cetinbas, Naniye. "Reciprocal regulation of glutamine metabolism and reactive oxygen species." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45714.

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37

Tatla, Sangeeta. "The role of reactive oxygen species in lymphocyte activation." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244071.

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38

Zeng, Zhen [Verfasser], Albert [Akademischer Betreuer] Gollhofer, and Daniel [Akademischer Betreuer] König. "Effects of dietary strategies on reactive oxygen species production." Freiburg : Universität, 2021. http://d-nb.info/1237617979/34.

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39

Arellanes, Chuautemoc. "Measurements of reactive oxygen species in the particle phase." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1679290751&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Sun, Zhenning, and 孫振宁. "Studies on fluorescent probes for the specific detection of reactive oxygen species and reactive nitrogen species in living cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38677490.

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41

Mallon, P. T. "The modulation of experimental colitis by reactive oxygen species scavengers." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484983.

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Inflammatory bowel disease is a common condition causing debilitating symptoms. Existing treatments are successful in many cases but there are a significant proportion of patients in whom conventional therapy fails or results in significant side effects. Alternative treatments are therefore being sought. Reactive oxygen species have been implicated in the pathogenesis of human IBO and experimental colitis. Edaravone and mesna are drugs which have been licenced for use in clinical practice for conditions other than IBO. Edaravone is a potent scavenger of reactive oxygen species such as the hydr

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42

Sand, Carsten. "Pharmacological investigations on reactive oxygen species in the cardiovascular system." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/64883.

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Edmonds, Sally Elizabeth. "Hypoxia and reactive oxygen species : therapeutic implications for rheumatoid synovitis." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286596.

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Rahman, Mashrur. "Reactive oxygen species mediated regulation of autophagy in skeletal muscles." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121322.

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Skeletal muscles comprise of approximately 50% of the human body mass and are critical organs for enabling locomotion and exerting metabolic control. Autophagy, a lysosome-dependant catabolic process involved in the degradation of long-lived proteins and organelles, is an important process responsible for maintaining muscle homeostasis. Reactive Oxygen Species (ROS) has been shown to induce autophagy in many different cell types. In this study, we evaluate the effects of physiological levels of mitochondrial-derived reactive oxygen species (ROS) on skeletal muscle autophagy. In differentiated

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45

Wolfe, James T. "A role for reactive oxygen species in apoptotic cell death." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/34277.

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Apoptosis is a well studied mechanism of controllable cell death, implicated in various disease states. Among other features, it can be characterised morphologically by cell shrinkage, nucleolar disintegration, chromatin condensation and membrane blebbing. Biochemically, apoptotic cell death is most commonly characterised by DNA fragmentation. Originally, it was thought that the cleavage of chromatin between nucleosomes was the biochemical hallmark of apoptosis. More recently it has been shown that the formation of large DNA fragments (30 kilobase-pairs) occurs in the absence of and as a precu

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Perkins, Talayia Nayette. "The effect of reactive oxygen species on aged skeletal muscle." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/46503.

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The production of reactive oxygen species (ROS) may be a contributor to the progression of sarcopenia. Sarcopenia is a generic term for the loss of skeletal muscle mass, quality and strength. ROS are usually produced by radiation, but are also the byproducts of aerobic metabolism. ROS have been found to mediate various pathological conditions in a variety of tissues, to cause oxidative damage to DNA, proteins, and lipids with advancing age, and is presumably a major factor contributing to changes associated with aging. The purpose of this investigation was to determine whether the sarcopl

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47

Zhu, Haizhou. "Novel Reactive Oxygen Species Activated Scaffold from Mechanism to Application." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573811146199126.

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48

Li, Xinyuan. "Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-induced Endothelial Cell Activation." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/320473.

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Pharmacology<br>Ph.D.<br>Lysophosphatidylcholines (LPCs) are a class of pro-inflammatory lipids that play important roles in atherogenesis. LPC activates endothelial cells (ECs) to upregulate adhesion molecules, cytokines and chemokines, which is the initiation step of atherogenesis. However, the mechanisms underlying LPC-triggered EC activation are not fully understood. Previously considered as the toxic by-products of cellular metabolism, mitochondrial reactive oxygen species (mtROS) are recently found to directly contribute to both the innate and adaptive immune responses. Here we tested a

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Al-Nu'airat, Jomana. "Implications of reactive oxygen species (ROS) in initiating chemical reactions." Thesis, Al-Nu'airat, Jomana (2018) Implications of reactive oxygen species (ROS) in initiating chemical reactions. PhD thesis, Murdoch University, 2018. https://researchrepository.murdoch.edu.au/id/eprint/42916/.

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This thesis presents a series of scientific studies exploring the initiation of various chemical reactions with reactive oxygen species (ROS), mainly singlet oxygen. These studies have revealed new mechanistic insights in environmental, industrial and biological systems, have described the associated set of reactions, have illustrated the detection of new radicals i.e., environmentally persistent free radicals (EPFR), and have provided a new insight explaining the spontaneous fire in coal mines. Comprehensive experimental and quantum-mechanical calculations afforded the investigation of oxidat

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50

Winkler, Jonathan Alexander. "Improving antibiotic activity by manipulating bacterial reactive oxygen species metabolism." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12675.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>The discovery of antibiotics was one of the most important medical breakthroughs of the twentieth century, having a broad impact on overall life expectancy and public health. Unfortunately, antibiotic discovery

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