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Journal articles on the topic 'Real-life use cases'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Woźniak, Aleksandra. "Leadless pacemaker – potential indications for use based on real life cases." In a good rythm 1, no. 46 (2018): 31–35. http://dx.doi.org/10.5604/01.3001.0011.6497.

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Implantation of leadless pacemakers is associated with significantly fewer complications when compared to conventional pacemakers due to elimination of transvenous leads, which are among the weakest components of the pacing system. There are patients in whom implantation of a conventional transvenous pacemaker is very troublesome and problematic or associated with a higher risk of complications, including infectious, as a result of a very limited venous access or use of central veins for other purposes (for example haemodialysis or administration of drugs). We present two real life clinical ca

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Diarra, Ava, Maxime Degrendel, Isabelle Eberl, et al. "Real-Life Cefiderocol Use in Bone and Joint Infection: A French National Cohort." Antibiotics 14, no. 4 (2025): 388. https://doi.org/10.3390/antibiotics14040388.

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Background: Cefiderocol (CFD) is a novel siderophore cephalosporin developed for the treatment of infections involving multidrug-resistant (MDR) Gram-negative bacilli (GNB) infections (1–3). For bone and joint infections (BJIs), the use of CFD is currently neither part of its market authorization nor recommended, and has not yet been assessed by large-scale studies. Objectives: To fill the scarcity of data regarding the use of CFD in BJIs, we aimed to describe patients’ and infection characteristics along with the outcomes of the infection. Methods: We conducted a retrospective observational m

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Barca, Francesco, Dario Pasquale Mucciolo, Tomaso Caporossi, Gianni Virgili, Ruggero Tartaro, and Stanislao Rizzo. "Italian real-life experience on the use of ocriplasmin." BMJ Open Ophthalmology 3, no. 1 (2018): e000110. http://dx.doi.org/10.1136/bmjophth-2017-000110.

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ObjectiveTo evaluate the success of an intravitreal injection of ocriplasmin to release symptomatic vitreomacular traction (VMT) and close a full-thickness macular hole.Methods and analysisAn observational retrospective multicentre study conducted in Italy. Patients with symptomatic distortion and loss of vision secondary to VMT were included in the study. The patients received a single injection of ocriplasmin and were followed up for 1, 3 and 6 months. Best-corrected visual acuity (BCVA) and spectral domani OCT (SD-OCT) were performed for patient assessment, and adverse events were recorded

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Fernández Pérez, Mónica, Xabier Gutiérrez López de Ocariz, Carlos Pisón Herrero, et al. "Real-Life Multicenter Experience of the Use of Avatrombopag." Blood 142, Supplement 1 (2023): 5433. http://dx.doi.org/10.1182/blood-2023-182693.

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INTRODUCTION: Avatrombopag is a thrombopoietin receptor agonist (TPO-RA) indicated for the treatment of severe thrombocytopenia in adult patients with chronic liver disease (CLD) who are scheduled for an invasive procedure and for chronic primary immune thrombocytopenia (ITP) in adult patients who do not respond to other treatments. In our health area, its use was approved in December 2020, although previously it could be used under individualized approval by the competent body in this matter. OBJECTIVES: The main objective is to report the experience of Avatrombopag in patients, from two thir

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Blaye, Olivier Le. "Variations in internal standard response: some thoughts and real-life cases." Bioanalysis 11, no. 18 (2019): 1715–25. http://dx.doi.org/10.4155/bio-2019-0146.

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Internal standards are essential to ensure the reliability of chromatographic bioanalytical methods. However, this only holds true if the response of the internal standard is adequately monitored. A difference needs to be made between isolated variations in a limited number of samples, which can be easily handled using objective criteria triggering the re-analysis of the affected samples and more complex situations such as trends or systematic differences, which may require the use of scientific judgment, trigger further investigations and ultimately result in the rejection of analytical runs.

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Nataliia Marko. "Writing effective use cases for Application Programming Interfaces (APIs)." International Journal of Science and Research Archive 15, no. 2 (2025): 1712–14. https://doi.org/10.30574/ijsra.2025.15.2.1635.

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The article presents the review of use cases as one of the effective means of requirements documentation for technology project, in particularly for those that involves data exchange via Application Programming Interfaces (APIs). It includes review of certain pitfalls that may occur and steps how to avoid them. The article also offers several best practices and a template, based on the real-life implementation of change requests.

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Zhang, Joe, Joshua Symons, Paul Agapow, et al. "Best practices in the real-world data life cycle." PLOS Digital Health 1, no. 1 (2022): e0000003. http://dx.doi.org/10.1371/journal.pdig.0000003.

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With increasing digitization of healthcare, real-world data (RWD) are available in greater quantity and scope than ever before. Since the 2016 United States 21st Century Cures Act, innovations in the RWD life cycle have taken tremendous strides forward, largely driven by demand for regulatory-grade real-world evidence from the biopharmaceutical sector. However, use cases for RWD continue to grow in number, moving beyond drug development, to population health and direct clinical applications pertinent to payors, providers, and health systems. Effective RWD utilization requires disparate data so

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Fried, Iris, Michael Weintraub, Dalia Waldman, and Shoshana Revel-Vilk. "Real-life Use of IV Naxitamab for Children With Relapsed/Refractory Neuroblastoma." Journal of Pediatric Hematology/Oncology 47, no. 6 (2025): e282-e284. https://doi.org/10.1097/mph.0000000000003081.

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The anti-GD2 antibody Naxitamab requires complicated pain management due to significant adverse effects (AEs). Herein, we report the safety and feasibility of a simplified administration protocol. Between November 2021 and July 2023, 102 Naxitamab infusions were administered at Shaare Zedek Hospital with ketamine as the only analgesic drug during Naxitamab infusion. Pain was controlled in all the cases. Other grade 3-4 AEs, occurred in 10/102 infusions (10%), and none of the patients stopped Naxitamab due to infusion-related AEs. Single-agent ketamine is safe and effective for Naxitamab-infusi

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Marty, C. Bernard, J. Farnarier, L. Puyuelo, J. Capdet, S. Bringer, and M. Martinez. "Real-life use of 21-gene signature: A retrospective analysis of 46 cases from private practice." European Journal of Cancer 138 (October 2020): S56. http://dx.doi.org/10.1016/s0959-8049(20)30675-4.

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Berninger, Anja. "Empathy – Real-Life and Fiction-Based." Journal of Literary Theory 12, no. 2 (2018): 224–40. http://dx.doi.org/10.1515/jlt-2018-0013.

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Abstract In response to the so-called paradox of fiction, Kendall Walton famously argued that our affective reactions to fictions differ structurally from real-life emotions. Many authors now reject the idea that there really is a paradox of fiction. But, even if this is true, Walton may have been right in that there really are far reaching differences between the way we respond to fictions and our real-life emotional reactions. That is, even if we do not believe the paradox of fiction is a paradox, it can still lead us to doubt the homogeneity of our emotional responses and to reflect on the

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Hidalgo-Tenorio, Carmen, Inés Pitto-Robles, Daniel Arnés García, et al. "Cefto Real-Life Study: Real-World Data on the Use of Ceftobiprole in a Multicenter Spanish Cohort." Antibiotics 12, no. 7 (2023): 1218. http://dx.doi.org/10.3390/antibiotics12071218.

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Background: Ceftobiprole is a fifth-generation cephalosporin that has been approved in Europe solely for the treatment of community-acquired and nosocomial pneumonia. The objective was to analyze the use of ceftobiprole medocaril (Cefto-M) in Spanish clinical practice in patients with infections in hospital or outpatient parenteral antimicrobial therapy (OPAT). Methods: This retrospective, observational, multicenter study included patients treated from 1 September 2021 to 31 December 2022. Results: A total of 249 individuals were enrolled, aged 66.6 ± 15.4 years, of whom 59.4% were male with a

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Olinic, Dan, Mihail Spinu, Calin Homorodean, Mihai Ober, and Maria Olinic. "Real-Life Benefit of OCT Imaging for Optimizing PCI Indications, Strategy, and Results." Journal of Clinical Medicine 8, no. 4 (2019): 437. http://dx.doi.org/10.3390/jcm8040437.

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Background: The aim of this study was to evaluate the benefit of standard practice Optical Coherence Tomography (OCT) imaging, as a complement to coronary angiography (CA), for optimizing the indications, strategy, and results of percutaneous coronary interventions (PCI). Methods: We retrospectively analyzed 182 patients with OCT imaging in a single tertiary center. Results: OCT use had a low prevalence (3.1% of 4256 CAs and 1.7% of 3027 PCIs). OCT was used post-CA in 71.5% and post-PCI in 28.5% of cases, mainly in acute coronary syndromes—95.6%. OCT was performed for borderline lesions in 43.

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Heberle, Andreas, Welf Löwe, Anders Gustafsson, and Örjan Vorrei. "Digitalization Canvas - Towards Identifying Digitalization Use Cases and Projects." JUCS - Journal of Universal Computer Science 23, no. (11) (2017): 1070–97. https://doi.org/10.3217/jucs-023-11-1070.

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Nowadays, many companies are running digitalization initiatives or are planning to do so. There exist various models to evaluate the digitalization potential of a company and to define the maturity level of a company in exploiting digitalization technologies summarized under buzzwords such as Big Data, Artificial Intelligence (AI), Deep Learning, and the Industrial Internet of Things (IIoT). While platforms, protocols, patterns, technical implementations, and standards are in place to adopt these technologies, small- to medium-sized enterprises (SME) still struggle with digitalization. This is

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Brescini, Lucia, Filippo Della Martera, Gianluca Morroni, et al. "Use of Dalbavancin in Skin, Bone and Joint Infections: A Real-Life Experience in an Italian Center." Antibiotics 10, no. 9 (2021): 1129. http://dx.doi.org/10.3390/antibiotics10091129.

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Dalbavancin is a lipoglycopeptide approved for the treatment of acute bacterial skin and skin structure infections (ABSSSI). The aim of the study was to evaluate the efficacy and safety in all patients who received at least one administration of dalbavancin. Methods: We carried out a retrospective study of the use of dalbavancin in 55 patients at the Azienda Ospedaliera Ospedali Riuniti Umberto I (Ancona, Italy) from February 2017 to May 2020 and compared “on label” and “off label” use of dalbavancin in ABSSSI and non-ABSSSI. Results: A total of 55 patients were included in the study. The medi

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Russo, Elena, Francesco Giombi, Giovanni Paoletti, et al. "Use, Abuse, and Misuse of Nasal Medications: Real-Life Survey on Community Pharmacist’s Perceptions." Journal of Personalized Medicine 13, no. 4 (2023): 579. http://dx.doi.org/10.3390/jpm13040579.

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Background: Medication overuse is an increasing global problem, especially for those rhinology diseases whose management requires over-the-counter drugs. This observational community pharmacy-based study aimed to investigate the actual use of the best-selling topical nasal medications and to characterize the clinical issues underlying their query through the pharmacist’s perception. Methods: In the pilot phase, a preliminary survey was developed by a team of researchers and tested on a small sample of practitioners to assess usability and intelligibility. Eventual amendments were made accordin

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Andretta, Elena, Enrico Finazzi Agrò, Massimiliano Calabrese, Luca Orecchia, Antonietta Furlan, and Cristina Zuliani. "Antimuscarinics for neurogenic overactive bladder in multiple sclerosis: real-life data." Therapeutic Advances in Urology 14 (January 2022): 175628722211224. http://dx.doi.org/10.1177/17562872221122484.

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Background: Antimuscarinics (AMs) represent the mainstay of treatment for storage lower urinary tract symptoms (LUTS) but few data are available on their impact in multiple sclerosis (MS) patients. Objective: To assess effectiveness and tolerability of AMs in MS patients with neurogenic detrusor overactivity (NDO). Methods: Sixty consecutive outpatients, who started treatment with AMs at one centre, were recruited. The primary endpoint was change in Patient’s Perception of Intensity of Urgency Scale (PPIUS) at 6 months; secondary endpoints were post-void residual urine (PVR) and pads used dail

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Eftimie Spitz, Raphaël, Stefan Lucian Popa, Simona Grad, Dan Lucian Dumitrascu, Abdulrahman Ismail, and Teodora Surdea-Blaga. "The Use of Proton Pump Inhibitors in Patients with Liver Cirrhosis: Real Life Experience." Journal of Clinical Medicine 13, no. 17 (2024): 5155. http://dx.doi.org/10.3390/jcm13175155.

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(1) Background: Proton pump inhibitors (PPIs) are commonly prescribed for gastric disorders. In patients with liver cirrhosis, PPI use is associated with an increased risk of spontaneous bacterial peritonitis and increased mortality rates; therefore, they should be used with caution. This study aims to evaluate the appropriateness of PPI prescriptions in hospitalized cirrhotic patients against current clinical guidelines to identify patterns of misuse and guide better prescribing practices. (2) Methods: A retrospective study was conducted on liver cirrhosis inpatients in an internal medicine d

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Bamber, E. Michael, and Linda Smith Bamber. "Using 10-K Reports Brings Management Accounting to Life." Issues in Accounting Education 21, no. 3 (2006): 267–90. http://dx.doi.org/10.2308/iace.2006.21.3.267.

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The accounting profession and business community have called for educators to present accounting in more realistic business contexts. Annual reports and 10-Ks provide a wealth of information that brings accounting to life, but use of these reports is typically confined to financial accounting courses. The first objective of this paper is to describe a process by which instructors can use a real companya's 10-K to create a series of mini-cases for cost and management accounting courses. These cases are intended to bridge the gap between typical end-of-chapter problems and full-blown Harvard-sty

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T, .Aditya Sai Srinivas, Thulasi Thanmai B., David Donald A., Thippanna G., Venkat Sai I., and V. Dwaraka Srihith I. "Battle of the Algorithms: An Exposé on Classification Techniques in Machine Learning." Journal of Advancement in Software Engineering and Testing 6, no. 3 (2023): 1–9. https://doi.org/10.5281/zenodo.8138139.

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<em>Machine learning has become a powerful tool in various domains, and practitioners are constantly seeking real-life use cases to develop unique and practical projects. In this context, a compelling machine learning project involves comparing classification algorithms, which allows for a comprehensive evaluation of their performance. This article aims to provide insights into comparing classification algorithms in machine learning, focusing on practicality and uniqueness. By utilizing Python, we showcase a detailed comparison of various classification algorithms to facilitate understanding a

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Madsen, Jens Koed, Nicole Lauren George, and Andreia Cury Fernandes. "The Pedagogical Use of Didactic Classes for Teaching Cognitive Psychology." Teaching and Learning Inquiry 12 (May 27, 2024): 1–16. http://dx.doi.org/10.20343/teachlearninqu.12.15.

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The didactic class is a pedagogical tool meant to increase classroom interactivity by encouraging student discussion of real-life cases in connection with theory. This paper evaluates the pedagogical impact of using a one-off didactic class where an external expert is brought in to discuss how to relate a cognitive psychology course’s content to real-life problems. Using a mixed-methods approach, we measure the undergraduate students’ sense of conceptual understanding, their perspective on applying cognitive sciences, their sense of belonging to the department, and their motivation to work. St

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Yacobovich, Joanne, Jerry Stein, Michael B. Jordan, et al. "Compassionate Use of Emapalumab in Children with Life-Threatening Disorders: Real-World Data." Blood 142, Supplement 1 (2023): 7335. http://dx.doi.org/10.1182/blood-2023-187398.

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Introduction: Life threatening hyperinflammation occurs in hemophagocytic lymphohistiocytosis (HLH) and during acute rejection of hematopoietic stem cell (HSC) grafts. Both conditions reflect acute activation of the immune system, in part due to overproduction of proinflammatory cytokines, particularly interferon gamma (IFNγ). Emapalumab, a fully human monoclonal antibody that binds to IFNγ, is approved by the FDA for refractory or recurrent primary HLH (pHLH) or in patients intolerant to conventional therapy. Off-label use of emapalumab has been reported for treatment of secondary HLH (sHLH)

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Hervé de Beaulieu, Martin, Mayank Shekhar Jha, Hugues Garnier, and Farid Cerbah. "Unsupervised Prognostics based on Deep Virtual Health Index Prediction." PHM Society European Conference 7, no. 1 (2022): 193–99. http://dx.doi.org/10.36001/phme.2022.v7i1.3359.

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Prediction of the Remaining Useful Life (RUL) for industrial systems has been facilitated by the acquisition of large amounts of real-time data and the use of deep learning methods. However, the vast majority of these methods rely on the availability of extensive RUL-labeled data, which is not the case for most of real industrial applications. The goal of this paper is to show how unsupervised learning can provide alternative ways to address this issue. The proposed method is essentially made of two steps. First, a Virtual Health Index (VHI) is extracted in an unsupervised manner from the raw

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Ferriero, Mariaconsiglia, Francesco Prata, Umberto Anceschi, et al. "Oncological Outcomes of Patients with High-Volume mCRPC: Results from a Longitudinal Real-Life Multicenter Cohort." Cancers 15, no. 19 (2023): 4809. http://dx.doi.org/10.3390/cancers15194809.

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Registrative trials recommended the use of upfront chemotherapy in high-volume metastatic prostate cancer. We reported survival outcomes of patients with high-volume mCRPC treated with ARTA in a chemo-naïve setting compared to patients treated with chemotherapy as first-line from a longitudinal real-life multicenter series. We retrospectively collected data on mCRPC patients treated at six centers. The dataset was queried for high-volume disease (defined as more than 6 bone lesions or bulky nodes ≥ 5 cm). We compared the main clinical features of chemo-naïve versus chemo-treated patients. The

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Ambrosioni, Juan, Jhon Rojas Liévano, Leire Berrocal, et al. "Real-life experience with bictegravir/emtricitabine/tenofovir alafenamide in a large reference clinical centre." Journal of Antimicrobial Chemotherapy 77, no. 4 (2022): 1133–39. http://dx.doi.org/10.1093/jac/dkab481.

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Abstract Background The use of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) is mainly based on robust, pivotal clinical trials. Objectives To provide data on clinical use of BIC/FTC/TAF in real life. Patients and methods This was an observational, retrospective and single-centre study. We included all adult, treatment-naive (TN) and treatment-experienced (TE) people living with HIV (PLWH) starting BIC/FTC/TAF from 8 June 2018. We evaluated effectiveness [on treatment (OT), modified intention-to-treat (mITT) and intention-to-treat (ITT)], tolerability and safety in those patien

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Boyko, A. N., V. M. Alifirova, D. V. Pashkovskaya, et al. "Experience with the use of cladribine tablets in real-life clinical practice: independent analysis of data from 12 Russian clinical centres." Neurology, Neuropsychiatry, Psychosomatics 16 (August 7, 2024): 44–50. http://dx.doi.org/10.14412/2074-2711-2024-2s-44-50.

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Multiple sclerosis (MS) is an autoimmune-inflammatory and neurodegenerative disease of the central nervous system. The article analyses the ability of cladribine, which due to its selective lymphotoxic effect on activated cells and central effect on immunomodulation in brain tissue underwent successful clinical trials in 2010, when it was (temporarily) approved in Russia.Objective: to analyse the effect of cladribine tablets in daily practice on the course of MS over 3–4 year observational period after immune reconstitution therapy (IRT) in several neurological clinics from different regions o

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El-Lababidi, N., and P. Frühauf. "P596 Adalimumab use in Paediatric Inflammatory Bowel Disease: A single centre real-life experience." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i531—i532. http://dx.doi.org/10.1093/ecco-jcc/jjab232.722.

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Abstract Background Anti-TNF-α, including infliximab and adalimumab (ADA), plays a crucial role in the treatment of Paediatric Inflammatory Bowel Disease (PIBD). This study evaluates the efficacy of ADA in children ≤ 19 years in a single European centre. Methods A 6-year retrospective analysis of prospectively collected data of PIBD patients treated with ADA (10/2015 onward). Wellbeing, clinical and laboratory findings were assessed at each visit. A mean, median and a standard deviation were calculated were applicable. ANOVA (analysis of variances) was used for evaluation of presence of statis

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Chen, Hongxi. "Analysis on Price Discrimination in Real-world: Chinas Cases." Advances in Economics, Management and Political Sciences 30, no. 1 (2023): 216–21. http://dx.doi.org/10.54254/2754-1169/30/20231476.

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This article aims to incorporate real-life examples of companies into the theory of price discrimination. With regards to price discrimination, inspiration can be gained from analyzing results from different viewpoints. Through analysis, it can be said that price discrimination occurs in peoples daily lives in a very subtle way. By separating the link between some companies actions and rule-setting, many basic principles of price discrimination can be found. Consumers may not notice it unless they are very attentive. Companies will always use different methods to divert consumers attention to

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Bunyaratavej, Sumanas, Pattriya Jirawattanadon, Chudapa Sereeaphinan, Supisara Wongdama, Sanchai Sombatmaithai, and Charussri Leeyaphan. "Mobile Device Digital Photography for Teledermatology Consultation: Real-Life Situations." Siriraj Medical Journal 75, no. 12 (2023): 871–79. http://dx.doi.org/10.33192/smj.v75i12.264488.

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Objective: The use of mobile phones for teledermatology consultations is increasing. In this study, we aimed to describe photographic problems in teledermatology performed via mobile phones and their effects on diagnostic decision-making. Materials and Methods: Three dermatologists independently reviewed the medical histories and photographs of patients taken by primary-care physicians for teledermatology between January 2018 and August 2020. The consensus of the dermatologists’ decision-making was categorized into “definite diagnoses given,” “probable diagnoses given,” and “unable to provide

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Cattaneo, Chiara, Doriana Gramegna, Alessandro Busca, et al. "Isavuconazole in Hematological Patients: Results of a Real-Life Multicenter Seifem Study." Blood 132, Supplement 1 (2018): 3710. http://dx.doi.org/10.1182/blood-2018-99-113772.

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Abstract Introduction. The outcome of invasive fungal infections (IFI), particularly aspergillosis in acute leukemia (AL) patients (pts), has improved over the last years, but IFI still remain a major clinical issue in hematological pts, both for its severity and for the toxicity and potential drug interactions of antifungal treatments. Isavuconazole (ISV) is a new antifungal agent, with a modest drug-drug interaction profile, reduced drug-related adverse events and efficacy similar to voriconazole as demonstrated in a non-inferiority trial of IFI treatment (Maertens, Lancet 2016). To confirm

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Ferrari, Federica, Fortunata Civitelli, Francesca Ardenti Morini, et al. "The Use of Antigenic SARS-CoV-2 Point-of-Care Test: The Italian Pediatric Real-Life Experience." Clinical Pediatrics 61, no. 1 (2021): 34–41. http://dx.doi.org/10.1177/00099228211053916.

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In Italy, during the second epidemic wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapid antigenic (Ag) test at point-of-care (POCT) station were employed to quickly evaluate large numbers of swabs. We collected data of all children who underwent the Ag test in our hospital. All positive patients were recalled to perform reverse transcription polymerase chain reaction. A total of 2133 tests were collected over 1 month. Clinical data of 1941 children (median age = 3.7 years) were analyzed: 1343 (69.2%) patients complained of symptoms, 594 (30.6%) had a history of close c

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Magri, Vittorio, Gianpaolo Perletti, Tommaso Cai, Konstantinos Stamatiou, Alberto Trinchieri, and Emanuele Montanari. "Levofloxacin for NIH Category II Chronic Bacterial Prostatitis: A Real-Life Study." Chemotherapy 64, no. 1 (2019): 8–16. http://dx.doi.org/10.1159/000499034.

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Background: Mounting worldwide resistance trends make the use of fluoroquinolone (FQ) antibacterial agents increasingly difficult. This is felt more acutely in the case of urogenital infections, which are mainly caused by Gram-negative pathogens. For years, levofloxacin and other FQs have been the first-line drugs for treating National Institutes of Health (NIH) category II chronic bacteria prostatitis (CBP). Eradication rates achieved by levofloxacin in the frame of randomized trials vary greatly, ranging between 71 and 86%. Objectives: This was a retrospective observational study to investig

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Biondetti, Pierpaolo, Francesco Cicchetti, Gaetano Valerio Davide Amato, et al. "Real-Life Clinical Use and Outcomes of Fusion Imaging-Guided Percutaneous Microwave Ablation of Hepatocellular Carcinoma: Experience from Two Italian Centers." Diagnostics 15, no. 13 (2025): 1573. https://doi.org/10.3390/diagnostics15131573.

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Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Percutaneous thermal ablation is an effective treatment, but standard ultrasound (US) guidance is limited in cases of inconspicuous nodules. Ultrasound fusion imaging (USFI), which overlays cross-sectional imaging onto real-time US is an emerging technique that improves tumor visibility and technical feasibility. This study reports real-life outcomes of USFI-guided microwave ablation (MWA) for HCC in two Italian centers. Materials and Methods: In this multicentric retrospective study, 56 patients wit

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Sallam, Malik, Kholoud Al-Mahzoum, and Mohammed Sallam. "Generative Artificial Intelligence and Cybersecurity Risks: Implications for Healthcare Security Based on Real-life Incidents." Mesopotamian Journal of Artificial Intelligence in Healthcare 2024 (December 12, 2024): 184–203. https://doi.org/10.58496/mjaih/2024/019.

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Background: The potential of generative artificial intelligence (genAI) tools, such as ChatGPT, is being increasingly explored in healthcare settings. However, the same tools also introduce significant cybersecurity risks that could compromise patient safety, data integrity, and institutional trust. This study aimed to examine real-world security breaches involving genAI and extrapolate their potential implications for healthcare settings. Methods: Using a systematic Google News search and a consensus-based approach among the authors, five high-profile genAI breaches were identified and analyz

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Salciccia, Stefano, Valerio Santarelli, Giovanni Battista Di Pierro, et al. "Real-Life Comparative Analysis of Robotic-Assisted Versus Laparoscopic Radical Prostatectomy in a Single Centre Experience." Cancers 16, no. 21 (2024): 3604. http://dx.doi.org/10.3390/cancers16213604.

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Background: The advantage of a robotic-assisted (RARP) over a laparoscopic (LRP) approach in radical prostatectomy (RP) remains to be demonstrated. Aim: The aim of the study is to use a homogeneous population in real life and single primary surgeon surgery to analyze the oncological and functional results based on the type of surgical approach and pathological features. Methods: This is a prospective trial on non-metastatic prostate cancer (PCa) patients considered after a multidisciplinary decision to conduct a RP, using a RARP or LRP approach. A real-life setting was analyzed at our Urologic

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Zerbato, Verena, Gianfranco Sanson, Lisa Fusaro, et al. "Intravenous Fosfomycin for Difficult-to-Treat Infections: A Real-Life Multicentric Study in Italy." Antibiotics 14, no. 4 (2025): 401. https://doi.org/10.3390/antibiotics14040401.

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Background: Fosfomycin, an old antibiotic attracting renewed interest, offers a broad spectrum of activity and unique synergy with other agents. While widely used in severe infections, real-world data on intravenous fosfomycin remain limited. Objectives: This study aimed to describe the clinical and microbiological characteristics of patients treated with intravenous fosfomycin and to analyze its administration modalities in a real-world setting. Methods: A multicenter retrospective cohort study was conducted across five Italian hospitals. Adult patients receiving intravenous fosfomycin betwee

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Kossovsky, Alex Ely. "On the Mistaken Use of the Chi-Square Test in Benford’s Law." Stats 4, no. 2 (2021): 419–53. http://dx.doi.org/10.3390/stats4020027.

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Benford’s Law predicts that the first significant digit on the leftmost side of numbers in real-life data is distributed between all possible 1 to 9 digits approximately as in LOG(1 + 1/digit), so that low digits occur much more frequently than high digits in the first place. Typically researchers, data analysts, and statisticians, rush to apply the chi-square test in order to verify compliance or deviation from this statistical law. In almost all cases of real-life data this approach is mistaken and without mathematical-statistics basis, yet it had become a dogma or rather an impulsive ritual

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Thomas, John C. "Implications of real-world distributions and the conversation game for studies of human probability judgments." Behavioral and Brain Sciences 30, no. 3 (2007): 282–83. http://dx.doi.org/10.1017/s0140525x07001914.

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AbstractSubjects in experiments use real-life strategies that differ significantly from those assumed by experimenters. First, true randomness is rare in both natural and constructed environments. Second, communication follows conventions which depend on the game-theoretic aspects of situations. Third, in the common rhetorical stance of storytelling, people do not tell about the representative but about unusual, exceptional, and rare cases.

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Gaujoux-Viala, C., A. Basch, S. Lassoued, et al. "AB0388 FRENCH REAL LIFE SAFETY DATA ON THE USE OF TOFACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS: OBSERVATIONAL STUDY, DeFacTo." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1322.1–1322. http://dx.doi.org/10.1136/annrheumdis-2022-eular.601.

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BackgroundTofacitinib, an oral Janus Kinase inhibitor, is indicated in the treatment of adult patients (pts) with active, moderate to severe rheumatoid arthritis (RA).ObjectivesThe objective of this work is to describe the tofacitinib’s safety profile in the DeFacTo study (French prospective observational study).MethodsThe safety profile of tofacitinib was assessed on the basis of interim data from a descriptive analysis of pts having taken at least one dose of tofacitinib in the context of the DeFacTo study.ResultsOf the 313 pts enrolled in the study, 301 had received tofacitinib and were inc

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Koether, V., D. Launay, M. Reynaud, et al. "POS1265 REAL-LIFE MULTICENTRIC NATIONAL OBSERVATIONAL STUDY OF THE USE OF NINTEDANIB IN SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 976.1–976. http://dx.doi.org/10.1136/annrheumdis-2023-eular.252.

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BackgroundInterstitial Lung Disease related to Systemic Sclerosis (ILD-SSc) is the first cause of mortality rate in this disease [1]. Significative functional decline in Forced vital capacity is one of the major pronostic factor in ILD-SSc and evaluation of the FCV is a key part of the follow-up of patient [2]. Nintedanib is a tyrosine kinase inhibitor that has been shown to be effective in ILD-SSc by significantly slowing decline in CVF [3]. To this day, no real-life data are available in ILD-SSc.ObjectivesEvaluation of efficacity and tolerance profile of Nintedanib in ILD-SSc patients in rea

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Hoover, Emily, and Doug Foulk. "Using Decision Cases in Graduate Education: An Example." HortScience 31, no. 4 (1996): 568b—568. http://dx.doi.org/10.21273/hortsci.31.4.568b.

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Decision cases have been written for use in horticulture education for some time at the Univ. of Minnesota. How faculty involve graduate students in this process will be discussed using the decision case Sunny Hollow Orchard. This decision case concerns the need to make management decisions in a commercial apple orchard planted largely with Haralson, a russet-susceptible cultivar. The growers involved had to decide whether the application of GA4+7 for russet suppression was appropriate for their operation, given all the factors which required addressing. The case was written for use in fruit p

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Lunghi, Monia, Francesca Kaiser, Deborah Cardinali, et al. "Use of Ponatinib Alone or Combined with Other Therapies in Relapsed/Refractory Ph-like Acute Lymphoblastic Leukemia. a Campus ALL Real-Life Study." Blood 142, Supplement 1 (2023): 1507. http://dx.doi.org/10.1182/blood-2023-182091.

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Introduction. Ponatinib is a third-generation tyrosine kinase inhibitor (TKI) employed in relapsed/refractory (R/R) and, more recently, also in newly diagnosed Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Ph-like ALL is a genetically heterogenous subgroup that shares a common transcriptional profile, similar to that of true Ph+ ALL, though lacking the BCR::ABL1 rearrangement. Ph-like ALL is characterized by a poor prognosis, a high relapse rate and a worse overall survival if treated with standard chemotherapy. Several molecular pathways are involved, including JAK/STAT, CRLF2

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Bieth, Claire, Marc Antoine Benderra, Herve Foka Tichoue, et al. "Trastuzumab-deruxtecan in HER2-low metastatic/unresectable breast cancer: Real life data in two Parisian centers." Journal of Clinical Oncology 41, no. 16_suppl (2023): e13130-e13130. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e13130.

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e13130 Background: Trastuzumab-deruxtecan (TDXT) is an antibody-drug conjugate which has been approved for HER2-positive metastatic breast cancer (BC) treatment. DESTINY-Breast04 phase III clinical trial published in July 2022, TDXD was also shown to increase progression-free and overall survival in patients with HER2-low score metastatic/unresectable BC previously treated by 1 or 2 lines of chemotherapy, regardless of their hormone-receptor (HR) status. TDXD therefore has become a new therapeutic option in this population and has received an early access authorization in November 2022 in Fran

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Sánchez-Machín, Inmaculada, Ruperto González-Pérez, Elena Mederos-Luis, Sara García-Gil, and Paloma Poza-Guedes. "Real-World Outcomes and Healthcare Utilization of Lanadelumab in Spain: Insights from First Cohort of Difficult-to-Treat Hereditary Angioedema Cases." Allergies 5, no. 1 (2025): 3. https://doi.org/10.3390/allergies5010003.

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Background/Objectives: Hereditary angioedema (HAE) is a rare genetic condition marked by recurring episodes of intense swelling that affect the skin, gastrointestinal system, and airways. Lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, is approved for long-term prophylaxis (LTP) in HAE patients, and has shown substantial efficacy in reducing disease symptoms. This single-center, retrospective study analyzed the real-world impact of lanadelumab on healthcare resource utilization, angioedema episode frequency, and quality of life (QoL) among adult HAE patients treated at the

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Maraia, Zaira, Diletta Ricci, Marco Bruno Luigi Rocchi, et al. "Real-Life Analysis with Erenumab: First Target Therapy in the Episodic and Chronic Migraine’s Prophylaxis." Journal of Clinical Medicine 10, no. 19 (2021): 4425. http://dx.doi.org/10.3390/jcm10194425.

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Background: to research retrospectively the efficacy of Erenumab’s treatment, thus allowing to describe a summary more in line with the reality observed every day in clinical practice, relative to a sample of patients widely heterogeneous. The study aims to confirm the efficacy of Erenumab, in terms of reduction of migraine days per month, from baseline to month 12 of treatment. Additional objectives included a reduction in the number of days of symptomatic drug use and change from baseline in the Migraine Disability Assessment Score Questionnaire (MIDAS); Methods: the analysis included all pa

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Umarkhanova, Dildora. "Features of video conferencing as forms of mutual legal assistance in criminal matters." Общество и инновации 1, no. 2 (2020): 291–99. http://dx.doi.org/10.47689/2181-1415-vol1-iss2-pp291-299.

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The article analyzes the features of videoconferencing as a form of mutual legal assistance in criminal cases and the need for its The article analyzes the features of videoconferencing as a form of mutual legal assistance in criminal cases and the need for its use. The author explores the international and national legal framework for using video conferencing tools as innovative technologies. As a result of the study, gaps in the legislation on the use of videoconferences in matters of international cooperation in criminal matters were identified. In addition, the experience, advantages and d

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Mahé, Emmanuel, Smaïl Hadj-Rabia, Juliette Mazereeuw-Hautier, et al. "P05 Biologics combined with conventional systemic agents for the treatment of children with severe psoriasis: real-life data from the BiPe cohorts." British Journal of Dermatology 189, no. 3 (2023): e45-e45. http://dx.doi.org/10.1093/bjd/ljad259.015.

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Abstract Combined therapies, defined as treatment modalities involving combinations of two or more drugs, are used with three main aims: to increase the efficacy of each drug; to reduce the toxicity of each drug; and, in some cases, to reduce costs by reducing the required dosages of each treatment. We explored the use of combinations of conventional systemic therapies and biologics in children with psoriasis in daily practice from the 170 children in the Franco–Italian BiPe cohorts to evaluate the use, efficacy and safety of combined conventional systemic–biologic therapies. In total, 33 chil

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Rahman, Md Minhazur, Md Ibne Joha, Md Shahriar Nazim, and Yeong Min Jang. "Enhancing IoT-Based Environmental Monitoring and Power Forecasting: A Comparative Analysis of AI Models for Real-Time Applications." Applied Sciences 14, no. 24 (2024): 11970. https://doi.org/10.3390/app142411970.

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The Internet of Things (IoT) is transforming industries by integrating sensors and connectivity into everyday objects, enabling enhanced monitoring, management, and automation through Machine-to-Machine (M2M) communication. Despite these advancements, the IoT faces limitations in accurately predicting environmental conditions and power consumption. This study proposes an advanced IoT platform that combines real-time data collection with secure transmission and forecasting using a hybrid Long Short-Term Memory (LSTM)–Gated Recurrent Unit (GRU) model. The hybrid architecture addresses the comput

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Trimboli, Pierpaolo, Lorenzo Scappaticcio, Annamaria De Bellis, et al. "Different Formulations of Levothyroxine for Treating Hypothyroidism: A Real-Life Study." International Journal of Endocrinology 2020 (January 20, 2020): 1–5. http://dx.doi.org/10.1155/2020/4524759.

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Objective. Hypothyroid patients are treated by sodium levothyroxine (LT4). Tablet is the mostly used LT4 formulation, and the fasting regimen is required for the absorption of active principle. Also, gastrointestinal diseases and drugs may impair the LT4 bioavailability when tablet is used. Nonsolid LT4 formulations (i.e., liquid solution (LS) and soft gel (SG) capsule) were manufactured to overcome the limitations of LT4 tablet. This study was conceived to evaluate the performance of nonsolid LT4 formulations in a real-life scenario. Methods. Two institutions participated in the study that wa

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af Björkesten, C. G., T. Ilus, T. Hallinen, et al. "DOP26 Real-life dosing patterns and concomitant drug use among ustekinumab-treated patients with Crohn’s disease." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S066. http://dx.doi.org/10.1093/ecco-jcc/jjz203.065.

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Abstract Background Real-life long-term evidence on ustekinumab treatment in patients with Crohn’s disease (CD) is limited. We performed a retrospective non-interventional nation-wide chart review study of dosing and long-term clinical outcomes in Finnish CD patients treated with ustekinumab (FINUSTE2, EUPAS30920). Methods FINUSTE2 was carried out in 17 Finnish centres. Eligible patients were adults with CD, receiving an intravenous (IV) first dose of ustekinumab during 2017 or 2018. Data on disease activity, dosage, and concomitant medications were collected at baseline, 16 weeks, and 1 year

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Trasmundi, Sarah Bro, Thomas Wiben Jensen, Henriette Bruun, Katharina Kjølbye Wrist, and Sune Vork Steffensen. "The emergence and management of embodied dilemmas in psychotherapeutic interaction: a qualitative study." Qualitative Health Communication 2, no. 1 (2023): 41–57. http://dx.doi.org/10.7146/qhc.v2i1.132866.

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In this article we take an embodied and interactional perspective on how ethical dilemmas are being managed in situated interaction. Accordingly, we aim at linking ethical principles to real-life clinical practices in order to show how ethical dilemmas are less about abstract decision-making, and more about reasoning constrained by inter-bodily dynamics, affect and adaptive behaviour in situated interaction. We present two real-life cases of ethical dilemma management in a psychotherapeutic setting. We use the innovative method, Cognitive Event Analysis, to investigate the interaction in which

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