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Journal articles on the topic 'Real-Time Quaking-Induced Conversion'

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Published: 4 June 2021

Last updated: 13 February 2022

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1

Atarashi, Ryuichiro, Kazunori Sano, Katsuya Satoh, and Noriyuki Nishida. "Real-time quaking-induced conversion." Prion 5, no. 3 (2011): 150–53. http://dx.doi.org/10.4161/pri.5.3.16893.

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2

Kang, Hae-Eun, Youngwon Mo, Raihah Abd Rahim, Hye-Mi Lee, and Chongsuk Ryou. "Prion Diagnosis: Application of Real-Time Quaking-Induced Conversion." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/5413936.

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Prions composed of pathogenic scrapie prion protein (PrPSc) are infectious pathogens that cause progressive neurological conditions known as prion diseases or transmissible spongiform encephalopathies. Although these diseases pose considerable risk to public health, procedures for early diagnosis have not been established. One of the most recent attempts at sensitive and specific detection of prions is the real-time quaking-induced conversion (RT-QuIC) method, which measures the activity of PrPScaggregates or amyloid formation triggered by PrPScseeds in the presence of recombinant PrP. In this

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3

Godal, D., SLR Simon, K. Cheng, and JD Knox. "Un nouveau test diagnostique de la maladie de Creutzfeldt-Jakob : la conversion provoquée par tremblement en temps réel (RT-QulC)." Relevé des maladies transmissibles au Canada 41, no. 8 (2015): 221–25. http://dx.doi.org/10.14745/ccdr.v41i08a02f.

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4

Haley, Nicholas J., Rachel Rielinger, Kristen A. Davenport, Katherine O'Rourke, Gordon Mitchell, and Jürgen A. Richt. "Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion." Journal of General Virology 98, no. 11 (2017): 2882–92. http://dx.doi.org/10.1099/jgv.0.000952.

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5

Atarashi, Ryuichiro, Katsuya Satoh, Kazunori Sano, et al. "Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion." Nature Medicine 17, no. 2 (2011): 175–78. http://dx.doi.org/10.1038/nm.2294.

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6

Manca, Matteo, and Allison Kraus. "Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays." Biomolecules 10, no. 9 (2020): 1233. http://dx.doi.org/10.3390/biom10091233.

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Neurodegenerative diseases are characterized by the accumulation of disease-related misfolded proteins. It is now widely understood that the characteristic self-amplifying (i.e., seeding) capacity once only attributed to the prions of transmissible spongiform encephalopathy diseases is a feature of other misfolded proteins of neurodegenerative diseases, including tau, Aβ, and αSynuclein (αSyn). Ultrasensitive diagnostic assays, known as real-time quaking-induced conversion (RT-QuIC) assays, exploit these seeding capabilities in order to exponentially amplify protein seeds from various biospeci

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7

Budhram, Adrian, Ryan G. Taylor, Jeff Fuller, Jorge G. Burneo, J. David Knox, and Stephen H. Pasternak. "The Predictive Value of Endpoint Quaking-Induced Conversion in Creutzfeldt-Jakob Disease." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46, no. 5 (2019): 595–98. http://dx.doi.org/10.1017/cjn.2019.72.

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ABSTRACT:Creutzfeldt-Jakob disease (CJD) is a fatal neurological illness for which accurate diagnosis is paramount. Real-time quaking-induced conversion (RT-QuIC) is a prion-specific assay with high sensitivity and specificity for CJD. The Canadian endpoint quaking-induced conversion (EP-QuIC) test is similar, but unlike RT-QuIC there is little data regarding its diagnostic utility in clinical practice. In this exploratory predictive value analysis of EP-QuIC in CJD, the negative predictive value (NPV) and positive predictive value (PPV) was 100% and 83%, respectively, with one false-positive

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8

Cheng, Keding, Angela Sloan, Brooks Waitt, et al. "Altered rPrP substrate structures and their influence on real-time quaking induced conversion reactions." Protein Expression and Purification 143 (March 2018): 20–27. http://dx.doi.org/10.1016/j.pep.2017.10.007.

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9

McGuire, Lynne I., Alexander H. Peden, Christina D. Orrú, et al. "Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease." Annals of Neurology 72, no. 2 (2012): 278–85. http://dx.doi.org/10.1002/ana.23589.

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10

Ballan, Guillaume, Olivier Flabeau, Frédéric Bourdain, et al. "La méthode « Real-Time Quaking Induced Conversion » pour la protéine prion, un examen à connaître." Revue Neurologique 176 (September 2020): S5—S6. http://dx.doi.org/10.1016/j.neurol.2020.01.062.

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11

Godal, D., SLR Simon, K. Cheng, and JD Knox. "A new diagnostic test for Creutzfeldt-Jakob disease: Real-time quaking-induced conversion (RT-QuIC)." Canada Communicable Disease Report 41, no. 8 (2015): 192–95. http://dx.doi.org/10.14745/ccdr.v41i08a02.

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12

Manne, Sireesha, Naveen Kondru, Huajun Jin та ін. "α‐Synuclein Real‐Time Quaking‐Induced Conversion in the Submandibular Glands of Parkinson's Disease Patients". Movement Disorders 35, № 2 (2019): 268–78. http://dx.doi.org/10.1002/mds.27907.

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13

Sano, Kazunori. "Real-time Quaking-induced Conversion Analysis of Prion-like Seeding Activity of Pathological α-Synuclein". YAKUGAKU ZASSHI 139, № 7 (2019): 999–1005. http://dx.doi.org/10.1248/yakushi.18-00165-3.

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14

Denkers, Nathaniel D., Davin M. Henderson, Candace K. Mathiason, and Edward A. Hoover. "Enhanced prion detection in biological samples by magnetic particle extraction and real-time quaking-induced conversion." Journal of General Virology 97, no. 8 (2016): 2023–29. http://dx.doi.org/10.1099/jgv.0.000515.

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15

Park, Jeong-Ho, Yeong-Gon Choi, Yun-Jung Lee, et al. "Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea." Journal of Clinical Neurology 12, no. 1 (2016): 101. http://dx.doi.org/10.3988/jcn.2016.12.1.101.

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16

Magrinelli, Francesca, Michele Tinazzi, and Kailash P. Bhatia. "Toward an Early Real‐Time Quaking‐Induced Conversion–Based Diagnostic Biomarker for Lewy Body–Related Synucleinopathies." Movement Disorders Clinical Practice 7, no. 7 (2020): 780–81. http://dx.doi.org/10.1002/mdc3.13050.

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17

van Rumund, Anouke, Alison J. E. Green, Graham Fairfoul, Rianne A. J. Esselink, Bastiaan R. Bloem та Marcel M. Verbeek. "α‐Synuclein real‐time quaking‐induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism". Annals of Neurology 85, № 5 (2019): 777–81. http://dx.doi.org/10.1002/ana.25447.

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18

Henderson, Davin M., Kristen A. Davenport, Nicholas J. Haley, Nathaniel D. Denkers, Candace K. Mathiason, and Edward A. Hoover. "Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion." Journal of General Virology 96, no. 1 (2015): 210–19. http://dx.doi.org/10.1099/vir.0.069906-0.

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19

Elder, Alan M., Davin M. Henderson, Amy V. Nalls, et al. "Immediate and Ongoing Detection of Prions in the Blood of Hamsters and Deer following Oral, Nasal, or Blood Inoculations." Journal of Virology 89, no. 14 (2015): 7421–24. http://dx.doi.org/10.1128/jvi.00760-15.

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Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-induced conversion (wbRT-QuIC) to analyze whole blood collected from transmissible spongiform encephalopathy (TSE)-inoculated deer and hamsters throughout the incubation period for the presence of common prion protein-conversion competent amyloid (PrPC-CCA). We observed PrPC-CCA in the blood of TSE-inoculated hosts throughout the disease course from minutes p

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20

Sano, Kazunori, Ryuichiro Atarashi, and Noriyuki Nishida. "Structural conservation of prion strain specificities in recombinant prion protein fibrils in real-time quaking-induced conversion." Prion 9, no. 4 (2015): 237–43. http://dx.doi.org/10.1080/19336896.2015.1062201.

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21

Novi, G., A. Canosa, F. Nobili, et al. "Longitudinal brain magnetic resonance imaging and real-time quaking induced conversion analysis in presymptomatic Creutzfeldt-Jakob disease." European Journal of Neurology 25, no. 12 (2018): e127-e128. http://dx.doi.org/10.1111/ene.13807.

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22

Peden, Alexander H., Lynne I. McGuire, Nigel E. J. Appleford, et al. "Sensitive and specific detection of sporadic Creutzfeldt–Jakob disease brain prion protein using real-time quaking-induced conversion." Journal of General Virology 93, no. 2 (2012): 438–49. http://dx.doi.org/10.1099/vir.0.033365-0.

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Real-time quaking-induced conversion (RT-QuIC) is an assay in which disease-associated prion protein (PrP) initiates a rapid conformational transition in recombinant PrP (recPrP), resulting in the formation of amyloid that can be monitored in real time using the dye thioflavin T. It therefore has potential advantages over analogous cell-free PrP conversion assays such as protein misfolding cyclic amplification (PMCA). The QuIC assay and the related amyloid seeding assay have been developed largely using rodent-passaged sheep scrapie strains. Given the potential RT-QuIC has for Creutzfeldt–Jako

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23

Reddy, Vikas D., Almutasem Hamed, Neesha Settipalle, et al. "Real-time Quaking-induced Conversion Assay for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in a Living Patient." Infectious Diseases: Research and Treatment 12 (January 2019): 117863371987479. http://dx.doi.org/10.1177/1178633719874797.

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Creutzfeldt-Jakob disease (CJD) is the most common prion disease in humans with an incidence of one case per million inhabitants worldwide. The sporadic form of CJD (sCJD) is spontaneous and accounts for 85% of cases. Its symptoms include rapidly progressive dementia, ataxic gait, personality changes, myoclonus, coma, and eventually death. The challenging diagnosis is currently made by a combination of clinical criteria and supporting tests such as electroencephalography (EEG), magnetic resonance imaging (MRI) findings, and cerebrospinal fluid (CSF) studies. These modalities can be falsely pos

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24

Orrú, Christina D., Alessandra Favole, Cristiano Corona, et al. "Detection and Discrimination of Classical and Atypical L-Type Bovine Spongiform Encephalopathy by Real-Time Quaking-Induced Conversion." Journal of Clinical Microbiology 53, no. 4 (2015): 1115–20. http://dx.doi.org/10.1128/jcm.02906-14.

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Statutory surveillance of bovine spongiform encephalopathy (BSE) indicates that cattle are susceptible to both classical BSE (C-BSE) and atypical forms of BSE. Atypical forms of BSE appear to be sporadic and thus may never be eradicated. A major challenge for prion surveillance is the lack of sufficiently practical and sensitive tests for routine BSE detection and strain discrimination. The real-time quaking-induced conversion (RT-QuIC) test, which is based on prion-seeded fibrillization of recombinant prion protein (rPrPSen), is known to be highly specific and sensitive for the detection of m

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25

Yen, Chi-Fu, Dilshan S. Harischandra, Anumantha Kanthasamy, and Sanjeevi Sivasankar. "Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity." Science Advances 2, no. 7 (2016): e1600014. http://dx.doi.org/10.1126/sciadv.1600014.

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Prion protein (PrP) misfolding and oligomerization are key pathogenic events in prion disease. Copper exposure has been linked to prion pathogenesis; however, its mechanistic basis is unknown. We resolve, with single-molecule precision, the molecular mechanism of Cu2+-induced misfolding of PrP under physiological conditions. We also demonstrate that misfolded PrPs serve as seeds for templated formation of aggregates, which mediate inflammation and degeneration of neuronal tissue. Using a single-molecule fluorescence assay, we demonstrate that Cu2+ induces PrP monomers to misfold before oligome

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26

Mackenzie, Graeme, and Robert Will. "Creutzfeldt-Jakob disease: recent developments." F1000Research 6 (November 27, 2017): 2053. http://dx.doi.org/10.12688/f1000research.12681.1.

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Creutzfeldt-Jakob disease (CJD) is a rare prion disorder that has been the subject of both professional and public interest following the identification of variant CJD as a zoonotic disorder. There have been recent advances in diagnostic techniques, including real-time quaking-induced conversion and magnetic resonance imaging brain scan, that have allowed more accurate case recognition in all forms of CJD. Although the epidemic of variant CJD is clearly in decline, prevalence studies suggest that it may be premature to be complacent about concerns for public health.

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27

Masujin, Kentaro, Christina D. Orrú, Kohtaro Miyazawa, et al. "Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion." Journal of Clinical Microbiology 54, no. 3 (2016): 676–86. http://dx.doi.org/10.1128/jcm.02731-15.

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Prion diseases of cattle include the classical bovine spongiform encephalopathy (C-BSE) and the atypical H-type BSE (H-BSE) and L-type BSE (L-BSE) strains. Although the C- and L-BSE strains can be detected and discriminated by ultrasensitive real-time quaking-induced conversion (RT-QuIC) assays, no such test has yet been described for the detection of H-BSE or the discrimination of each of the major bovine prion strains. Here, we demonstrate an RT-QuIC assay for H-BSE that can detect as little as 10−9dilutions of brain tissue and neat cerebrospinal fluid samples from clinically affected cattle

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28

Dassanayake, Rohana P., Christina D. Orrú, Andrew G. Hughson, et al. "Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion." Journal of General Virology 97, no. 3 (2016): 803–12. http://dx.doi.org/10.1099/jgv.0.000367.

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29

Henderson, Davin M., Joanne M. Tennant, Nicholas J. Haley, Nathaniel D. Denkers, Candace K. Mathiason, and Edward A. Hoover. "Detection of chronic wasting disease prion seeding activity in deer and elk feces by real-time quaking-induced conversion." Journal of General Virology 98, no. 7 (2017): 1953–62. http://dx.doi.org/10.1099/jgv.0.000844.

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30

Shi, Song, Jens Wagner, Gerda Mitteregger-Kretzschmar, et al. "Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice." Journal of Neuropathology & Experimental Neurology 74, no. 9 (2015): 924–33. http://dx.doi.org/10.1097/nen.0000000000000233.

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31

Bongianni, Matilde, Christina Orrù, Bradley R. Groveman, et al. "Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples." JAMA Neurology 74, no. 2 (2017): 155. http://dx.doi.org/10.1001/jamaneurol.2016.4614.

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32

Sano, K., R. Atarashi, D. Ishibashi, T. Nakagaki, K. Satoh, and N. Nishida. "Conformational Properties of Prion Strains Can Be Transmitted to Recombinant Prion Protein Fibrils in Real-Time Quaking-Induced Conversion." Journal of Virology 88, no. 20 (2014): 11791–801. http://dx.doi.org/10.1128/jvi.00585-14.

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33

Yao, Yuan, Xiaoping Dong, Hongzhi Guan, and Qiang Lu. "Cerebrospinal fluid real-time quaking-induced conversion test for sporadic Creutzfeldt–Jakob disease in an 18-year-old woman." Medicine 96, no. 48 (2017): e8699. http://dx.doi.org/10.1097/md.0000000000008699.

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34

Haley, Nicholas J., Scott Carver, Laura L. Hoon-Hanks, et al. "Detection of Chronic Wasting Disease in the Lymph Nodes of Free-Ranging Cervids by Real-Time Quaking-Induced Conversion." Journal of Clinical Microbiology 52, no. 9 (2014): 3237–43. http://dx.doi.org/10.1128/jcm.01258-14.

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35

SAWADA, Kazuhei, Akio SUZUKI, Takeshi YAMASAKI, et al. "Estimation of prion infectivity in tissues of cattle infected with atypical BSE by real time-quaking induced conversion assay." Journal of Veterinary Medical Science 81, no. 6 (2019): 846–50. http://dx.doi.org/10.1292/jvms.19-0003.

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36

Cheng, Yo Ching, Samia Hannaoui, Theodore R. John, Sandor Dudas, Stefanie Czub, and Sabine Gilch. "Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion." PLOS ONE 11, no. 11 (2016): e0166187. http://dx.doi.org/10.1371/journal.pone.0166187.

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37

Green, Alison J. E. "RT-QuIC: a new test for sporadic CJD." Practical Neurology 19, no. 1 (2018): 49–55. http://dx.doi.org/10.1136/practneurol-2018-001935.

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The diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) can be difficult, but the real-time quaking-induced conversion (RT-QuIC) assays have made a considerable impact on its clinical diagnosis. This technique exploits the ability of the misfolded pathological form of prion protein (PrPSc) found in cerebrospinal fluid (CSF) to induce conversion of normal PrP to the misfolded form, which subsequently aggregates. The formation of these aggregates of misfolded PrP is monitored in real time using fluorescent dyes. The current sensitivity of CSF RT-QuIC undertaken at the UK National CJD Research

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38

John, Theodore R., Hermann M. Schätzl, and Sabine Gilch. "Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay." Prion 7, no. 3 (2013): 253–58. http://dx.doi.org/10.4161/pri.24430.

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39

Candelise, Niccolò, Matthias Schmitz, Susana Margarida Da Silva Correia, et al. "Applications of the real-time quaking-induced conversion assay in diagnosis, prion strain-typing, drug pre-screening and other amyloidopathies." Expert Review of Molecular Diagnostics 17, no. 10 (2017): 897–904. http://dx.doi.org/10.1080/14737159.2017.1368389.

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40

Schmitz, Matthias, Maria Cramm, Franc Llorens, et al. "The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases." Nature Protocols 11, no. 11 (2016): 2233–42. http://dx.doi.org/10.1038/nprot.2016.120.

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41

Shi, Song, Gerda Mitteregger-Kretzschmar, Armin Giese, and Hans A. Kretzschmar. "Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues." Acta Neuropathologica Communications 1, no. 1 (2013): 44. http://dx.doi.org/10.1186/2051-5960-1-44.

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42

McGuire, Lynne I., Anna Poleggi, Ilaria Poggiolini, et al. "Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt-jakob disease: An international study." Annals of Neurology 80, no. 1 (2016): 160–65. http://dx.doi.org/10.1002/ana.24679.

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43

Henderson, Davin M., Nathaniel D. Denkers, Clare E. Hoover, Nina Garbino, Candace K. Mathiason, and Edward A. Hoover. "Longitudinal Detection of Prion Shedding in Saliva and Urine by Chronic Wasting Disease-Infected Deer by Real-Time Quaking-Induced Conversion." Journal of Virology 89, no. 18 (2015): 9338–47. http://dx.doi.org/10.1128/jvi.01118-15.

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ABSTRACTChronic wasting disease (CWD) is an emergent, rapidly spreading prion disease of cervids. Shedding of infectious prions in saliva and urine is thought to be an important factor in CWD transmission. To help to elucidate this issue, we applied anin vitroamplification assay to determine the onset, duration, and magnitude of prion shedding in longitudinally collected saliva and urine samples from CWD-exposed white-tailed deer. We detected prion shedding as early as 3 months after CWD exposure and sustained shedding throughout the disease course. We estimated that the 50% lethal dose (LD50)

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44

Ubagai, Kaori, Shigeo Fukuda, Tsuyoshi Mori, et al. "Discrimination between L-type and C-type bovine spongiform encephalopathy by the strain-specific reactions of real-time quaking-induced conversion." Biochemical and Biophysical Research Communications 526, no. 4 (2020): 1049–53. http://dx.doi.org/10.1016/j.bbrc.2020.03.183.

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45

Nakhleh, Rasha, Sophia Tenaye Tessema, and Abdullahi Mahgoub. "Creutzfeldt-Jakob disease as a cause of dementia." BMJ Case Reports 14, no. 5 (2021): e240020. http://dx.doi.org/10.1136/bcr-2020-240020.

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Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder belonging to the family of transmissible spongiform encephalopathies. The disease is believed to be caused by an abnormal isoform of a cellular glycoprotein known as the prion protein. Our patient is an 84-year-old Caucasian man who presented to the geriatric clinic for evaluation of short-term memory loss and decreased concentration which started 3 months prior to initial evaluation. Rapid progression of dementia demonstrated by severe impairment in tasks with a predominantly visual component, including

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46

Davenport, Kristen A., Davin M. Henderson, Jifeng Bian, Glenn C. Telling, Candace K. Mathiason, and Edward A. Hoover. "Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion." Journal of Virology 89, no. 18 (2015): 9524–31. http://dx.doi.org/10.1128/jvi.01439-15.

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ABSTRACTThe propensity for transspecies prion transmission is related to the structural characteristics of the enciphering and new host PrP, although the exact mechanism remains incompletely understood. The effects of variability in prion protein on cross-species prion transmission have been studied with animal bioassays, but the influence of prion protein structure versus that of host cofactors (e.g., cellular constituents, trafficking, and innate immune interactions) remains difficult to dissect. To isolate the effects of protein-protein interactions on transspecies conversion, we used recom

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47

Cheng, Keding, Angela Sloan, Kristen M. Avery, Michael Coulthart, Michael Carpenter, and J. David Knox. "Exploring Physical and Chemical Factors Influencing the Properties of Recombinant Prion Protein and the Real-Time Quaking-Induced Conversion (RT-QuIC) Assay." PLoS ONE 9, no. 1 (2014): e84812. http://dx.doi.org/10.1371/journal.pone.0084812.

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48

Hyeon, Jae Wook, Su Yeon Kim, Sol Moe Lee, et al. "Anti-Prion Screening for Acridine, Dextran, and Tannic Acid using Real Time–Quaking Induced Conversion: A Comparison with PrPSc-Infected Cell Screening." PLOS ONE 12, no. 1 (2017): e0170266. http://dx.doi.org/10.1371/journal.pone.0170266.

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49

Levavasseur, Etienne, Anne-Gaëlle Biacabe, Emmanuel Comoy, et al. "Detection and partial discrimination of atypical and classical bovine spongiform encephalopathies in cattle and primates using real-time quaking-induced conversion assay." PLOS ONE 12, no. 2 (2017): e0172428. http://dx.doi.org/10.1371/journal.pone.0172428.

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50

Hayashi, Yuichi, Yasushi Iwasaki, Nobuaki Yoshikura, et al. "An autopsy-verified case of steroid-responsive encephalopathy with convulsion and a false-positive result from the real-time quaking-induced conversion assay." Prion 11, no. 4 (2017): 284–92. http://dx.doi.org/10.1080/19336896.2017.1345416.

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