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Journal articles on the topic 'Realtime qPCR'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Marnis, Huria, Bambang Iswanto, Romy Suprapto, Imron Imron, and Raden Roro Sri Pudji Sinarni Dewi. "IDENTIFIKASI ZIGOSITAS IKAN LELE (Clarias gariepinus) TRANSGENIK F-2 YANG MEMBAWA GEN HORMON (PhGH) DENGAN MENGGUNAKAN METODE REALTIME-qPCR." Jurnal Riset Akuakultur 11, no. 1 (2016): 39. http://dx.doi.org/10.15578/jra.11.1.2016.39-46.

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Produktivitas ikan budidaya dapat ditingkatkan melalui teknologi transgenesis. Populasi ikan lele transgenik cepat tumbuh telah dihasilkan dan karakter biologisnya telah diketahui. Namun informasi zigositas ikan lele transgenik perlu ditelaah lebih lanjut. Penelitian ini bertujuan untuk mengidentifikasi zigositas ikan lele transgenik F-2. Zigositas ikan lele transgenik diidentifikasi dengan menggunakan metode real-time qPCR (RT-qPCR) dan uji progeni. Identifikasi zigositas melalui uji progeni, dilakukan dengan mendeteksi transgen (PhGH) pada individu-individu F-3 hasil persilangan transgenik F

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Hikmawati, Isna, Hendro Wahjono, Martini Martini, et al. "Persistence of Dengue Virus (DENV-1, 2, 3,4) Transovarial-Transgenerational with Realtime Polymerase Chain Reaction (qPCR) in Ae. Aegypti and Ae. Albopictus (Diptera: Culicidae)." Women Health Care and Issues 4, no. 8 (2021): 01–09. http://dx.doi.org/10.31579/2642-9756/090.

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Ae. aegypti and Ae. albopictus have an important role in DHF transmission because they can simultaneously transmit the dengue virus vertically / transovarially or horizontally. This phenomenon indicates the persistence of the dengue virus by vectors. The aim of this research was to prove the persistence of the transovarial-transgenerational dengue virus (DENV-1,2,3,4) with real time polymerase chain reaction (qPCR) in Ae. aegypti and Ae. albopictus (Diptera: Culicidae). Quasi experimental design with intervention infects DENV 1-2-3-4 serotypes in Ae. aegypti and Ae. albopictus intratoracally.

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Amor, Isabel, Ana Alberola, Adolfo De Salazar, et al. "Evaluation of the Vaginal Panel Realtime PCR kit (Vircell, SL) for diagnosing vaginitis: A comparative study with routinely used diagnostics." PLOS ONE 19, no. 11 (2024): e0313414. http://dx.doi.org/10.1371/journal.pone.0313414.

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Vaginitis is a prevalent clinical disorder associated with several adverse health consequences, prompting women to seek medical care. In this study we evaluate the Vaginal Panel Real-Time PCR kit (qPCR test) against routinely used diagnostics for detection of bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomoniasis. A total of 1011 vaginal swab specimens were analyzed. The routinely diagnostic methods for BV was Gram stain-based Nugent score. VVC presence was detected by culture, and Candida species were identified using MALDI-TOF MS. Trichomonas vaginalis was identified by

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Okangba, C. C., T. A. Ajani, G. C. Okangba, et al. "Evaluation of the detection of Plasmodium falciparum infection in Urine, Plasma, Serum, and Dried Blood Spots using real-time Polymerase Chain React." Nigerian Journal of Parasitology 44, no. 1 (2023): 78–86. http://dx.doi.org/10.4314/njpar.v44i1.7.

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Access to timely and accurate diagnostic tests has a significant impact on the management of malaria disease which is a global concern. Polymerase chain reaction (PCR) detection of Plasmodium DNA is highly sensitive in diagnosing malaria. The specimen of choice for this assay has been whole blood samples from patients with malaria caused by Plasmodium species. Nucleic acids can also be detected in urine, serum, plasma, and Dried Blood Spots (DBS) samples but there are few studies describing the diagnostic performance of PCR. Therefore, this study was aimed at evaluating the performance of real

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Rublenko, N. "Identification of Salmonella spp and serovars Typhimurium, Enteritidis by qPCR." Naukovij vìsnik veterinarnoï medicini, no. 1(154) (May 21, 2020): 21–31. http://dx.doi.org/10.33245/2310-4902-2020-154-1-21-31.

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This article presents the results of the identification of the Salmonella genus as well as serovars Enteritidis and Typhimurium by a real-time polymerase chain reaction. We constructed three pairs of primers and fluorescent probes to simultaneously identify the Salmonella genus, serovars Enteritidis and Typhimurium in a qPCR. The specificity of the primers was evaluated on Salmonella strains of different serovars from the National Center for Strains of Microorganisms (UNCMS) strains of the State Scientific Control Institute of Biotechnology and Strains of Microorganisms (SSCIBSM) and 46 Salmon

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Dyer, Clare E. F., Naomi E. Clarke, Dinh Ng Nguyen, et al. "Assessing the efficacy of albendazole against hookworm in Vietnam using quantitative PCR and sodium nitrate flotation." PLOS Neglected Tropical Diseases 16, no. 10 (2022): e0010767. http://dx.doi.org/10.1371/journal.pntd.0010767.

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Preventive chemotherapy (PC), consisting of the regular distribution of anthelmintics to populations or groups of populations at risk, is the primary tool used to control soil-transmitted helminth (STH) infections. This strategy, whilst cost-effective, raises the concern of potential emergence of drug resistance. The efficacy of anthelmintics against STH infections is measured using cure rate (CR) and egg reduction rate (ERR), using microscopy-based techniques such as the Kato-Katz thick smear. However, Kato-Katz has low sensitivity, especially for low-intensity infections, and requires fresh

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Rasmussen, S., A. J. Parsons, Q. Liu, H. Xue, and J. A. Newman. "High nutrient supply and carbohydrate content reduce endophyte and alkaloid concentration." NZGA: Research and Practice Series 13 (January 1, 2007): 135–38. http://dx.doi.org/10.33584/rps.13.2006.3103.

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Two controlled environment experiments were performed to test the effects of nitrogen, phosphorus and carbohydrates on endophyte (Neotyphodium lolii) and alkaloid concentrations in ryegrass (Lolium perenne). Three perennial ryegrass cultivars ('high sugar grasses' AberDove and AberDart; control Fennema) that differ in carbohydrate content were infected with three strains of N. lolii (common strain, CS; AR1; AR37). Infected and uninfected plants were grown under high (9 mM) and low (2.25 mM) nitrogen (AberDove, Fennema; CS, AR1, AR37) or under high (2 mM KH2PO4) and low (0.05 mM KH2PO4) phospho

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Karolak, Justyna A., Barbara Ginter-Matuszewska, Katarzyna Tomela, et al. "Further evaluation of differential expression of keratoconus candidate genes in human corneas." PeerJ 8 (August 20, 2020): e9793. http://dx.doi.org/10.7717/peerj.9793.

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Background Keratoconus (KTCN) is a progressive eye disease, characterized by changes in the shape and thickness of the cornea that results in loss of visual acuity. While numerous KTCN candidate genes have been identified, the genetic etiology of the disease remains undetermined. To further investigate and verify the contribution of particular genetic factors to KTCN, we assessed 45 candidate genes previously indicated as involved in KTCN etiology based on transcriptomic and genomic data. Methods The RealTime ready Custom Panel, covering 45 KTCN candidate genes and two reference transcripts, h

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Długosz-Pokorska, Angelika, Tomasz Janecki, Anna Janecka, and Katarzyna Gach-Janczak. "Synergistic Effects of Oxaliplatin, 5-Fluorouracil, and Novel Synthetic Uracil Analog U-359 on Breast Cancer Cell Carcinogenesis." International Journal of Molecular Sciences 26, no. 7 (2025): 2964. https://doi.org/10.3390/ijms26072964.

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Breast cancer presents significant global challenges, necessitating effective treatments to combat drug resistance and minimize chemotherapy side effects. This study evaluated the cytotoxic effects of U-359, Oxaliplatin (Ox), and 5-Fluorouracil (5-FU) in MCF-7 and MCF-10A cells using MTT and RealTime-GLO assays. Morphological changes were assessed by light microscopy following Wright–Giemsa staining. Apoptosis induction was studied using qPCR for apoptotic markers, the RealTime-Glo™ Annexin V assay, and the cleaved PARP1 ELISA assay. Caspase 8 and 9 activities, ABCB1, ABCG2, and NF-κB protein

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Weng, Wenfeng, Xiang Lu, Meiliang Zhou, et al. "FtbZIP12 Positively Regulates Responses to Osmotic Stress in Tartary Buckwheat." International Journal of Molecular Sciences 23, no. 21 (2022): 13072. http://dx.doi.org/10.3390/ijms232113072.

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ABFs play a key role in regulating plant osmotic stress. However, in Tartary buckwheat, data on the role of ABF genes in osmotic stress remain limited and its associated mechanism in osmoregulation remain nebulous. Herein, a novel ABF family in Tartary buckwheat, FtbZIP12, was cloned and characterized. FtbZIP12 is a transcriptional activator located in the nucleus; its expression is induced by NaCl, mannitol, and abscisic acid (ABA). Atopic expression of FtbZIP12 in Arabidopsis promoted seed germination, reduced damage to primary roots, and improved the tolerance of seedlings to osmotic stress

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Tilawati Sitanggang, Fardiah, James Perdinan Simanjuntak, Nasrah Nasrah, Arvida Bar, and Ridwansyah Ridwansyah. "Comparative Analysis of Threshold Cycle Results for RNA Extraction in SARS-CoV-2 RT-qPCR Using Magnetic Beads and Spin Column Methods." Bionatura Journal 1 1, no. 1 (2024): 1–10. http://dx.doi.org/10.21931/bj/2024.01.01.64.

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Coronavirus Disease-2019 (COVID-19) belongs to the large family of SARS-CoV viruses, initially emerging in 2002-2003. In humans, this virus triggers respiratory infectious diseases. COVID-19, a new variant of SARS-CoV, was identified in humans following an unprecedented incident in Wuhan, China, in December 2019. This virus typically manifests mild symptoms, including a runny nose, sore throat, cough, and fever. The Nucleic Acid Amplification Test (NAAT), specifically the realtime Reverse Transcription Polymerase Chain Reaction (rRT-PCR) examination, is recommended by the World Health Organiza

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Tilawati Sitanggang, Fardiah, James Perdinan Simanjuntak, Nasrah Nasrah, Ridwansyah Ridwansyah, and Arvida Bar. "Comparative Analysis of Threshold Cycle Results for RNA Extraction in SARS-CoV-2 RT-qPCR Using Magnetic Beads and Spin Column Methods." Bionatura 9, no. 1 (2024): 1–10. http://dx.doi.org/10.21931/rb/2024.09.01.64.

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Coronavirus Disease-2019 (COVID-19) belongs to the large family of SARS-CoV viruses, initially emerging in 2002-2003. In humans, this virus triggers respiratory infectious diseases. COVID-19, a new variant of SARS-CoV, was identified in humans following an unprecedented incident in Wuhan, China, in December 2019. This virus typically manifests mild symptoms, including a runny nose, sore throat, cough, and fever. The Nucleic Acid Amplification Test (NAAT), specifically the realtime Reverse Transcription Polymerase Chain Reaction (rRT-PCR) examination, is recommended by the World Health Organiza

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Habel, A., F. Nassar, M. Itani, et al. "Mir-21 and Mir-125b as theranostic biomarkers for epithelial ovarian cancer in Tunisian women." African Health Sciences 23, no. 2 (2023): 256–64. http://dx.doi.org/10.4314/ahs.v23i2.29.

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Background: Ovarian cancer (OC) is the third most common cancer in women and the leading cause of death associated with gynecologic tumors. Because this disease is asymptomatic in the early stages, most patients are not diagnosed until the late stages. This highlights the need for the development of diagnostic biomarkers. MicroRNAs (miRNAs), small non-coding RNAs, are currently being explored as potential biomarkers for the early detection of various malignancies in humans. However, their expression and diagnostic value in OC have not been well studied. Materials and Methods: the plasma

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Romagnoli, Cecilia, Roberto Zonefrati, Elena Lucattelli, et al. "In Vitro Effects of PTH (1-84) on Human Skeletal Muscle-Derived Satellite Cells." Biomedicines 11, no. 4 (2023): 1017. http://dx.doi.org/10.3390/biomedicines11041017.

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Parathyroid hormone (PTH) is a hormone secreted by the parathyroid glands. Despite its well-known characterized anabolic and catabolic actions on the skeleton, the in vitro effects of PTH on skeletal muscle cells are limited and generally performed on animal models. The aim of this study was to evaluate the effects of a short impulse of PTH (1-84) on the proliferation and the differentiation of skeletal muscle satellite cells isolated from human biopsies. The cells were exposed for 30 min to different concentrations of PTH (1-84), from 10−6 mol/L to 10−12 mol/L. ELISA was used to assay cAMP an

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Abdelwahab, Siddig Ibrahim, Loiy Elsir Ahmed Hassan, Amin M. S. Abdul Majid та ін. "Cucurbitacin L 2-O-β-Glucoside Demonstrates Apoptogenesis in Colon Adenocarcinoma Cells (HT-29): Involvement of Reactive Oxygen and Nitrogen Species Regulation". Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/490136.

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Emerging evidence suggests that reactive oxygen (ROS) and nitrogen (RNS) species can contribute to diverse signalling pathways of inflammatory and tumour cells. Cucurbitacins are a group of highly oxygenated triterpenes. Many plants used in folk medicine to treat cancer have been found to contain cucurbitacins displaying potentially important anti-inflammatory actions. The current study was designed to investigate the anti-ROS and -RNS effects of cucurbitacin L 2-O-β-glucoside (CLG) and the role of these signaling factors in the apoptogenic effects of CLG on human colon cancer cells (HT-29). T

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Ren, Jianwei, Zhiting Mo, Xia Deng та ін. "TPH1 inhibits bladder tumorigenesis by targeting HIF-1α pathway in bladder cancer". Asian Biomedicine 18, № 4 (2024): 171–79. http://dx.doi.org/10.2478/abm-2024-0023.

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Abstract Background BCa is the most common cancer of the urinary system. TPH1 has been reported to be associated with distinct tumorigenesis. However, the role of TPH1 in BCa remains to be clarified. Objectives Our aim is to demonstrate the molecular mechanism of TPH1 in BCa carcinogenesis and development. Methods In research, we explored the effect of TPH1 on T24 cells. Colony formation, soft agar, and cell proliferation assays were used to determine the survival and proliferative capacity of cells. Moreover, TPH1−/− cell lines were analyzed using CRISP-CAS9, and the recovery experiment was c

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Machnik, Grzegorz, E. Klimacka-Nawrot, D. Sypniewski, et al. "Porcine Endogenous Retrovirus (PERV) Infection of HEK-293 Cell Line Alters Expression of Human Endogenous Retrovirus (HERV-W) Sequences." Folia Biologica 60, no. 1 (2014): 35–46. http://dx.doi.org/10.14712/fb2014060010035.

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The risk of infections of human recipients after xenotransplantations is now mainly represented by porcine endogenous retroviruses (PERVs) as these particles are part of the porcine genome. As in all vertebrates, human genome harbours its own numerous genetic sequences of retroviral origin; it is estimated that they comprise about 8 % of the human genome. Because some of them play an important role in human physiology, it is valuable to estimate whether the presence of PERVs in human cells influences homeostasis of the human endogenous retrovirus (HERV) expression pattern. The aim of the study

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Stojcevic-Maletic, Jelena, Iva Barjaktarovic, Katarina Baculov, Velibor Cabarkapa, Vladimir Sakac, and Zoran Gojkovic. "Comparison of diagnostic efficacy of the Abbott RealTime SARS-CoV-2 assay and the BGI real-time fluorescent RT-PCR kit for the RT-PCR-based detection of Severe Acute Respiratory Syndrome Coronavirus-2." Srpski arhiv za celokupno lekarstvo, no. 00 (2023): 74. http://dx.doi.org/10.2298/sarh230201074s.

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Introduction/Objective. Based on the World Health Organization guidelines, the current "gold standard" to diagnose Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR). The objective of this study was to compare and analyze the detection performance of two different authorized SARS-CoV-2 nucleic acid detection assays: the Abbott RealTime SARS-CoV-2 (ACOV) assay and the BGI Real-Time Fluorescent RT-PCR (BGI) kit. Methods. Our study included 384 randomly selected nasopharyngeal and oropharyngeal swabs pre

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Čavić, Milena, Ana Krivokuća, Marijana Pavlović, et al. "EGFR mutation testing from liquid biopsy of non-small cell lung cancer at the Institute for Oncology and Radiology of Serbia." J BUON 25, no. 6 (2020): 2635–48. https://doi.org/10.5281/zenodo.5081786.

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Purpose: Resistance to tyrosine kinase inhibitors (TKIs) in lung cancer often occurs, so mutation testing from liquid biopsy is the method of choice as a minimally invasive approach that quickly provides information for additional therapeutic options. The purpose of this study was to assess the success rate and usefulness of EGFR testing from liquid biopsy at the Institute for Oncology and Radiology of Serbia (IORS). Methods: EGFR mutation testing was performed by realtime qPCR in 4750 tumor samples using the Cobas® EGFR Mutation Test v2. EGFR testing from 104 liquid biopsy samples was use

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Čavić, Milena, Ana Krivokuća, Marijana Pavlović, et al. "EGFR mutation testing from liquid biopsy of non-small cell lung cancer at the Institute for Oncology and Radiology of Serbia." J BUON 25, no. 6 (2020): 2635–42. https://doi.org/10.5281/zenodo.5584720.

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Purpose: Resistance to tyrosine kinase inhibitors (TKIs) in lung cancer often occurs, so mutation testing from liquid biopsy is the method of choice as a minimally invasive approach that quickly provides information for additional therapeutic options. The purpose of this study was to assess the success rate and usefulness of EGFR testing from liquid biopsy at the Institute for Oncology and Radiology of Serbia (IORS). Methods: EGFR mutation testing was performed by realtime qPCR in 4750 tumor samples using the Cobas® EGFR Mutation Test v2. EGFR testing from 104 liquid biopsy samples was use

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Ysrafil, Ysrafil, Indwiani Astuti, Sumadi Lukman Anwar та ін. "MicroRNA-155-5p Diminishes in Vitro Ovarian Cancer Cell Viability by Targeting HIF1α Expression". Advanced Pharmaceutical Bulletin 10, № 4 (2020): 630–37. http://dx.doi.org/10.34172/apb.2020.076.

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Purpose : Ovarian cancer is the most lethal of gynecological malignancies. Recently, the development of microRNA (miRNA) -based therapeutics that could impact broad cellular programs, leading to inhibition of cancer cell viability, is gaining attention in the therapeutic landscape. The therapy is based on the presence of aberrant expressions of miRNA in cancer cells. Decreasing of tumor suppressor miRNA expression causes upregulation of oncoprotein, which worsens the prognosis of the ovarian cancer. Methods: miR-155-5p mimics were carried by chitosan nanoparticles using new nanotechnology meth

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Wang, Jijun, Xiaolong Wang, Tong Chen, Liyu Jiang, and Qifeng Yang. "Huaier Extract Inhibits Breast Cancer Progression Through a LncRNA-H19/MiR-675-5p Pathway." Cellular Physiology and Biochemistry 44, no. 2 (2017): 581–93. http://dx.doi.org/10.1159/000485093.

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Background/Aims: Increasing evidence indicates that Huaier extract has promising therapeutic effects against cancer. However, the mechanisms that underlie its anti-tumor effects remain unclear. In recent years, various studies have shown that long noncoding RNAs (lncRNAs) play a critical role in the regulation of cancer development and progression. Here, we explored the role of lncRNAs in Huaier-induced tumor suppression. Methods: Microarray profiling was performed to identify the candidate lncRNAs affected by Huaier extract. Quantitative realtime PCR (qPCR) was used to evaluate the transfecti

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Ni, Dongjiao, Xiang Huang, Zhibo Wang, et al. "Expression characterization and transcription regulation analysis of porcine Yip1 domain family member 3 gene." Asian-Australasian Journal of Animal Sciences 33, no. 3 (2020): 398–407. http://dx.doi.org/10.5713/ajas.19.0076.

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Objective: The Yip1 domain family (YIPF) proteins were proposed to function in endoplasmic reticulum (ER) to Golgi transport and maintenance of the morphology of the Golgi, which were homologues of yeast Yip1p and Yif1p. YIPF3, the member 3 of YIPF family was a homolog of Yif1p. The aim of present study was to investigate the expression and regulation mechanism of porcine YIPF3.Methods: Quantitative realtime polymerase chain reaction (qPCR) was used to analyze porcine YIPF3 mRNA expression pattern in different tissues and pig kidney epithelial (PK15) cells stimulated by polyinosine-polycytidyl

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Nababan, Yanti Inneke, Hasan Nasrullah, Widanarni Widanarni, Munti Yuhana, and Alimuddin Alimuddin. "SUPLEMENTASI PREBIOTIK FRUKTOOLIGOSAKARIDA (FOS) MENINGKATKAN EKSPRESI GEN TERKAIT METABOLISME SERTA PERTUMBUHAN UDANG VANAME, Litopenaeus vannamei." Jurnal Riset Akuakultur 16, no. 4 (2022): 203. http://dx.doi.org/10.15578/jra.16.4.2021.203-210.

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Fruktooligosakarida (FOS) merupakan salah satu jenis prebiotik yang berpotensi menjadi feed additive dalam budidaya udang vaname. Penelitian ini bertujuan untuk mengevaluasi suplementasi prebiotik FOS melalui pakan terhadap tingkat ekspresi gen terkait metabolisme dan performa pertumbuhan udang vaname. Pakan uji berupa pakan komersil yang disuplementasi prebiotik FOS (Pre) dengan empat dosis berbeda dan masing-masing terdiri atas tiga ulangan yaitu: Pre-0% (kontrol), Pre-0,5%; Pre-1%, dan Pre-2%. Udang dengan bobot rata-rata 1,58 ± 0,21 g dipelihara dalam bak fiber (volume 1 m3) dengan kepadat

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Sandbichler, Adolf M., Bianca Jansen, Bettina A. Peer, Monika Paulitsch, Bernd Pelster, and Margit Egg. "Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells." Cellular Physiology and Biochemistry 46, no. 3 (2018): 1159–74. http://dx.doi.org/10.1159/000489058.

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Background/Aims: Reduced oxygen availability, hypoxia, is frequently encountered by organisms, tissues and cells, in aquatic environments as well as in high altitude or under pathological conditions such as infarct, stroke or cancer. The hypoxic signaling pathway was found to be mutually intertwined with circadian timekeeping in vertebrates and, as reported recently, also in mammals. However, the impact of hypoxia on intracellular metabolic oscillations is still unknown. Methods: For determination of metabolites we used Multilabel Reader based fluorescence and luminescence assays, circadian le

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Rogers, Amber, Maya Shebeshi, Morganna Gordon, Rula Atwani, Virginie Lazar, and Salvatore Condello. "Abstract B095: Tenascin C promotes ovarian cancer stem cells interactions with the niche." Cancer Research 84, no. 5_Supplement_2 (2024): B095. http://dx.doi.org/10.1158/1538-7445.ovarian23-b095.

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Abstract Background: Effective treatment of ovarian cancer (OC) is greatly impacted by advanced, late-stage diagnosis which usually presents with intra-peritoneal metastases, chemoresistance and high recurrence. The development of intra-peritoneal metastases is correlated with the formation of multicellular spheroids disseminated in the peritoneal fluid. Spheroid formation is promoted by a change of cell adhesion properties, enhanced secretion of extracellular matrix (ECM) components that stiffen the tumor stroma and promote the aberrant activation of oncogenic processes, including survival, i

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Gaudette, Brian, Neal N. Iwakoshi, and Lawrence H. Boise. "Bcl-xL Protects From UPR-Associated Apoptosis During Plasma Cell Differentiation." Blood 120, no. 21 (2012): 3288. http://dx.doi.org/10.1182/blood.v120.21.3288.3288.

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Abstract Abstract 3288 Understanding factors that control plasma cell survival is important for the development of therapeutic approaches to diseases including multiple myeloma and autoimmune disorders. As part of the program that allows for B cell differentiation to a plasma cell, a required signal includes the activation of an unfolded protein response (UPR). However unlike stress-induced activation of the UPR, induction of apoptosis does not occur, suggesting that compensatory survival signals are also activated during plasma cell differentiation. The compensatory survival pathways are less

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Ogweno Obuya, Clifford, Amolo Stephen Asito, V. Ann Stewart, and John N.Waitumbi. "EVALUATION OF PERFORMANCE OF TWO MONOPLEX QUANTITATIVE REAL TIME PCR ASSAYS IN COMPARISON TO MICROSCOPY FOR IDENTIFICATION OF MALARIA PARASITES." PARIPEX INDIAN JOURNAL OF RESEARCH, March 15, 2022, 32–38. http://dx.doi.org/10.36106/paripex/8706762.

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Background: Microscopy is the gold standard for Malaria diagnosis with shortcomings such as false positives, false negatives,errors in species identification,and errors in enumeration of parasites.Quantitative real-time PCR (qPCR) has improved submicroscopic malaria diagnosis. This study evaluated the performance, concordance, correlation and methods agreement of two monoplex qPCR assays against expert malaria microscopy for the detection and enumeration of malaria parasites. Methods: This was a cross sectional study utilizing 127 archived blood samples collected from five provinces in Kenya.

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Herdina, Anna Nele, Franz Ratzinger, Monika Breuer, et al. "Performance Evaluation of the Fully Automated NeuMoDx RT-PCR Platform for the Quantification of CMV and EBV DNA in EDTA Plasma: Implications for Clinical Management and Establishment of a Conversion Formula." Microbiology Spectrum, November 7, 2022. http://dx.doi.org/10.1128/spectrum.02157-22.

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Clinical management of solid organ transplant (SOT) patients requires the careful monitoring of immunosuppression and viral infection or reactivation. qPCR is the gold standard for the detection and quantification of very small amounts of viral DNA and allows for an early assessment of viral load kinetics. The tested NeuMoDx 96 platform provides faster results than the previously used RT-PCR workflows for CMV (Abbott m2000 and RealTime CMV assay) and EBV (LightCycler 480 II, Roche high pure extraction, and Altona RealStar EBV assay) DNA detection.

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Papaiakovou, Marina, Rubén O. Cimino, Nils Pilotte, et al. "Comparison of multi-parallel quantitative real-time PCRs targeting different DNA regions and detecting soil-transmitted helminths in stool." Parasites & Vectors 17, no. 1 (2024). http://dx.doi.org/10.1186/s13071-024-06464-6.

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Abstract Background Soil-transmitted helminths infect an estimated 18% of the world’s population, causing a significant health burden. Microscopy has been the primary tool for diagnosing eggs from fecal samples, but its sensitivity drops in low-prevalence settings. Quantitative real-time polymerase chain reaction (qPCR) is slowly increasing in research and clinical settings. However, there is still no consensus on preferred qPCR targets. Methods We aimed to compare soil-transmitted helminth (STH) DNA detection methods by testing naïve stool samples spiked with known quantities of STH eggs and

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Wanas, Mina, Manar Mansour, and Khaled Abou Aisha. "The Oncogenic lncRNA HOTAIR is not Expressed in the ATRT-MYC-derived Cell Line BT12." American Journal of Pathology & Research 2, no. 1 (2023). http://dx.doi.org/10.33425/2836-3647.1008.

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A typical teratoid Rhabdoid tumor (ATRT) is a highly aggressive pediatric tumor of the brain and spinal cord and is one of the most lethal neoplasms of early neonatal life, with a mortality rate exceeding 75%. Almost 95% of ATRT carry a biallelic SMARCB1 gene mutation. ATRT-MYC subgroup is distinguished by elevated levels of HOX Transcript Antisense Intergenic RNA, or HOTAIR, long non-coding RNA (LncRNA). We hypothesize that HOTAIR may play an epigenetic role in ATRT onset of tumorigenesis. In this study, we investigated the existence of potential interaction between the SMARCB1 and the HOTAIR

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Đỗ Như Bình. "ĐÁNH GIÁ HOẠT TÍNH ENZYME HOTSTART Taq DNA POLYMERASE T S N XU T QUY MÔ PHÒNG THÍ NGHI M". TẠP CHÍ PHÒNG CHỐNG BỆNH SỐT RÉT VÀ CÁC BỆNH KÝ SINH TRÙNG, 1 липня 2023, 47–52. http://dx.doi.org/10.59253/tcpcsr.v123i3.59.

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Việc tự sản xuất để chủ động cung cấp enzyme ADN polymerase với công nghệ “hot start”sẽ giúp tiết kiệm chi phí nghiên cứu để đánh giá một số đặc tính của chế phẩm enzyme hot startTaq polymerase tự sản xuất. Xác định hoạt tính enzym, độ nhiễm tạp DNA, RNA, khả năng hạnchế tạo primer dimer trong phản ứng PCR so sánh với enzym thương mại AmpliTaq Gold™ DNAPolymerase. Hoạt độ của chế phẩm Hotstart Taq DNA là 5000 U/ml, hoạt độ cao hơn enzymethương mại AmpliTaq Gold™ DNA Polymerase. Sự nhiễm tạp RNA và DNA ở mức khoảng 1,25phiên bản/µL chế phẩm. Enzyme tự sản xuất đảm bảo hiệu quả khuếch đại và khả

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Micalessi, Isabel M., Gaëlle A. V. Boulet, Johannes J. Bogers, Ina H. Benoy, and Christophe E. Depuydt. "High-throughput detection, genotyping and quantification of the human papillomavirus using real-time PCR." Clinical Chemistry and Laboratory Medicine 50, no. 4 (2012). http://dx.doi.org/10.1515/cclm.2011.835.

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AbstractThe establishment of the causal relationship between high-risk human papillomavirus (HR-HPV) infection and cervical cancer and its precursors has resulted in the development of HPV DNA detection systems. Currently, real-time PCR assays for the detection of HPV, such as the RealTime High Risk (HR) HPV assay (Abbott) and the cobas® 4800 HPV Test (Roche Molecular Diagnostics) are commercially available. However, none of them enables the detection and typing of all HR-HPV types in a clinical high-throughput setting. This paper describes the laboratory workflow and the validation of a type-

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Zhang, Guoli, Jian Li, Hongtao Wei, et al. "Inhibitory Effect of GnRH and Its Analog on Tongue Cancer Cells Might Be Related to Downregulation of GnRHR mRNA." Case Reports In Cancer, August 27, 2020, 1–5. http://dx.doi.org/10.31487/nl.crc.2020.01.02.

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Aim: We investigated the expression of type-I gonadotropin-releasing hormone receptor (GnRHR-I) in human tongue cancer SCC-25 cells and the effects of gonadotropin-releasing hormone (GnRH)-I and its analog triptorelin on SCC-25 cells and the related mechanisms of action. Methods: We used RT-PCR, realtime PCR (qPCR) and western blotting to detect the expression of GnRHR-I mRNA and protein in SCC-25 cells, We also used a Cell Counting Kit-8 (CCK-8) assay to calculate cell viability, after treatment with GnRH-I or triptorelin. Results: Results of agarose gel electrophoresis and DNA sequencing sho

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Zhu, Deqing, Xuan Li, Hao Gong, et al. "Effect and Mechanism of Transthyretin Over-Expression on Proliferation and Cell Cycle of Lung Cancer A549 Cells." Iranian Journal of Public Health, April 14, 2021. http://dx.doi.org/10.18502/ijph.v50i4.5995.

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Background: The effects of transthyretin (TTR) over-expression on the proliferation and cell cycle of nonsmall cell lung cancer (NSCLC) A549 cells and its possible mechanism were verified. Methods: A total of 196 LC patients and 20 healthy controls were enrolled at Tianjin Hospital, Tianjin, China between Apr 2017 and Oct 2017. The serum TTR content was detected by ELISA. Through lentiviral transfection method, NSCLC cells were divided into non-transfected group (group A), negative control group (group B) transfected with empty vector and experimental group (group C) transfected with TTR

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Xie, Yushuai, Shuangshuang Gao, Yiwen Cao, et al. "Molecular characterization and functional analysis of DIGIRR from golden pompano (Trachinotus ovatus)." Frontiers in Immunology 13 (August 24, 2022). http://dx.doi.org/10.3389/fimmu.2022.974310.

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Mammalian single immunoglobulin (Ig) interleukin-1 receptor related molecule (SIGIRR), an important member of the Toll/interleukin-1 receptor (TIR) family, plays important balancing roles in the inflammatory responses. In the present study, the double Ig interleukin-1 receptor related molecule (DIGIRR), the homologous of SIGIRR, was characterized in golden pompano (Trachinotus ovatus) (termed as trDIGIRR). The full-length cDNA of trDIGIRR was 2,167 bp with an open reading frame (ORF) of 1,572 bp encoding 523 amino acids. The trDIGIRR contained several conserved domains including a signal pepti

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H, Gou, Yu R, Luo J, Liu L, Sun X, and Xu C. "Circular RNA Circrna_0072387 Promotes Hepatoblastoma Progression by Regulating Hsa-Mir-490/Histone Deacetylase 2 Axis." Thrombosis & Haemostasis: Research 6, no. 1 (2022). http://dx.doi.org/10.26420/thrombhaemostres.2022.1074.

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Circular RNAs have been reported to be associated with the occurrence and progress of various cancers. However, its biological roles in hepatoblastoma (HB) remain undefined. This study intended to explain a possible mechanism of hsa_circ_0072387 (circ72387) in hepatoblastoma progression. The expression of circ72387, hsa-miR-490 (miR490) and histone deacetylase 2 (HDAC2) in HB tissues and cell lines (HepG2/Huh6) were determined by quantitative realtime polymerase chain reaction (qPCR) or Western blot. Cell Counting Kit-8 (CCK-8) and colony formation assay were used to detect the proliferation o

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Yadav, Rajeev Kumar, Madhavi Reddy Kambham, Saravan Kumar Parepally, Meenal Vyas, Krishna Reddy Manem, and Pagadala Damodaram Kamala Jayanthi. "Encounter With a Selfish Virus Sabotages Its Vector to Orient Toward Requisite Host Plant: A Case Study With Chili Leaf Curl Virus-Whitefly." Frontiers in Ecology and Evolution 10 (April 6, 2022). http://dx.doi.org/10.3389/fevo.2022.819023.

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Interactions of a virus with its vector and host plant have challenged entomologists, pathologists and biologists alike. Phytophagous insects depend on specific host volatile cues to locate suitable host plants for feeding and oviposition. Several studies have revealed that plant viruses modify their insect vector’s orientation toward specific host plants to facilitate their spread and survival. The ecological and molecular basis of this vector behavior modification remains largely unknown and was therefore explored in this study. Interestingly, host volatile preference for non-viruliferous fe

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Huang, haiqin, Xinlu Liu, Qinghua Li, Hang Su, Yuhan Meng, and Weiwei Yang. "Placental-derived exosomal miR-125b disrupts maternal endothelial function in preeclampsia." Physiology 38, S1 (2023). http://dx.doi.org/10.1152/physiol.2023.38.s1.5730039.

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Preeclampsia (PE) is an elusive life-threatening complication of pregnancy, and maternal endothelial dysfunction induced by components from the impaired placenta is a key hallmark of PE. Placenta-derived exosomes in maternal circulation has been reported with increased risk of PE, however, whether exosomes impaired endothelial cell function remains to be determined. We hypothesized that placental exosomes from preeclamptic patients disrupt endothelial function. We observed that placenta derived serum exosomes from preeclamtpic patients (PE-exo) significantly reduced VE-cadherin expression in p

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Suh, Soo Hwan, Jeong Su Lee, Seung Hwan Kim, Jan Vinjé, Soon Han Kim, and Geun Woo Park. "Evaluation of crAssphages as a potential marker of human viral contamination in environmental water and fresh leafy greens." Frontiers in Microbiology 15 (March 28, 2024). http://dx.doi.org/10.3389/fmicb.2024.1374568.

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CrAssphages are human gut bacteriophages with potential use as an indicator of human fecal contamination in water and other environmental systems. We determined the prevalence and abundance of crAssphages in water, food, and fecal samples and compared these estimates with the prevalence of norovirus. Samples were tested using two crAssphage-specific qPCR assays (CPQ056 and TN201-203) and for norovirus using TaqMan realtime RT-PCR. CrAssphage was detected in 40% of human fecal specimens, 61% of irrigation water samples, 58.5% of stream water samples, and 68.5% of fresh leafy greens samples. Int

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Jain, Sumit, Claudia Rodrigues, Huijun Yuan, Jing Liu, Keith A. Webster, and Nanette H. Bishopric. "Abstract 3385: Cardiac Stem Cell Survival During DNA Damage Is Regulated By Modulation Of Histone Acetyl Transferase p300." Circulation 118, suppl_18 (2008). http://dx.doi.org/10.1161/circ.118.suppl_18.s_416-a.

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Background: Many sources of oxidative stress, including ischemia/reperfusion and chemotherapy, can induce DNA damage in the heart, leading to loss of cardiomyocytes and development of heart failure. Cardiac stem cells (CSCs) may serve to regenerate injured myocardium. However, ischemic injury has been associated with senescence and apoptosis in CSCs, potentially limiting their contribution to tissue repair. The histone acetyltransferase p300 has been shown to be an important regulator of genome stability and is involved in cell survival in response to DNA damage. We hypothesized that p300 coul

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Jiang, Ziwei, Lixia Pei, Ying Xie, et al. "Ruyiping formula inhibits metastasis via the microRNA-134-SLUG axis in breast cancer." BMC Complementary Medicine and Therapies 21, no. 1 (2021). http://dx.doi.org/10.1186/s12906-021-03365-4.

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Abstract Background Metastasis is the leading cause of death among breast cancer patients. MicroRNA-134 has been reported to have a tumor-suppressive role in breast cancer. Ruyiping (RYP), a traditional Chinese formula, has been shown with the ability to reduce breast cancer metastasis in pre-clinical studies. This present study was designed to examine whether miR-134 was involved in RYP-inhibited breast cancer metastasis. Methods The expression of SLUG, E-Cadherin, N-Cadherin and miR-134 in MDA-MB-231 and 4 T1 cells treated with RYP or vehicle control were determined by quantitative realtime-

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Jahangir, Melika, Majid Nazari, Emad Babakhanzadeh, and Saeed Dehghan Manshadi. "Where do obesity and male infertility collide?" BMC Medical Genomics 17, no. 1 (2024). http://dx.doi.org/10.1186/s12920-024-01897-5.

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AbstractThe parallel rise in obesity and male infertility in modern societies necessitates the identification of susceptibility genes underlying these interconnected health issues. In our study, we conducted a comprehensive search in the OMIM database to identify genes commonly associated with male infertility and obesity. Subsequently, we performed an insilico analysis using the REVEL algorithm to detect pathogenic single nucleotide polymorphisms (SNPs) in the coding region of these candidate genes. To validate our findings in vivo, we conducted a comprehensive analysis of SNPs and gene expre

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Verberckmoes, Bo, Tamara De Vos, Karel Maelegheer, et al. "Evaluation of the applicability of internal controls on self-collected samples for high-risk human papillomavirus is needed." BMC Women's Health 23, no. 1 (2023). http://dx.doi.org/10.1186/s12905-023-02691-8.

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Abstract Background Self-collection of cervical samples to detect high-risk human papillomavirus (hr-HPV) is a trending topic in primary cervical cancer screening. This study evaluates the applicability of a self-sampling device to routine molecular procedures for hr-HPV detection. Methods In a primary health care facility in Kinshasa, Congo, 187 self-collected samples (Evalyn Brush) were gathered and sent to Ghent University Hospital (UZ Ghent) and Algemeen Medisch Labo (AML) in Belgium where routine tests for hr-HPV were applied (Abbott RealTime hr-HPV and qPCR (E6/E7), respectively). Sample

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Lim, Jina, Arshia Ehsanipour, Jinxiu Lu та ін. "F‐actin Assembly And Cytoskeletal Contraction Mediate TNF‐α Induced Hydrogel Retraction, Stiffness, And Nodule Formation By Murine Valvular Cells". FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.lb457.

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In calcific aortic valve disease (CAVD), a widespread and rapidly fatal disorder, the valve cusps undergo retraction, stiffening, and nodular calcification. Therapeutic options are limited to invasive procedures. The pro‐inflammatory cytokine, tumor necrosis factor‐alpha (TNF‐α), has been shown to contribute to CAVD progression; however, the mechanisms of its actions on cusp retraction and stiffening are not clear.We investigated the effects of TNF‐α on murine aortic valvular interstitial cells (VIC) within a 3‐dimensional, free‐floating, compliant collagen hydrogel to simulate their natural s

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Zamanpour, Maryam, Reza Arjmand, Jasem Saki, Neda Bavarsad, and Ali Jelowdar. "Preparation and characterization of paromomycin encapsulated in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis." Current Analytical Chemistry 20 (July 29, 2024). http://dx.doi.org/10.2174/0115734110314300240723050137.

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Introduction: Leishmaniasis is a disease caused by the Leishmania protozoa, with Cutaneous Leishmaniasis (CL) being the most common form of the illness. Paromomycin (PM) has recently garnered increased interest for its effectiveness against Leishmania, but it is hindered by limited efficacy, low oral bioavailability, and rapid clearance. As far as we know, there have been no studies examining the impact of nano lecithin-chitosan-containing paromomycin (Nano-PM) on CL. Therefore, the objective of the present study was to create Nano-PM and assess its effects on the promastigotes in vitro and on

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Zijie, Wang, Jiang Anan, Xiao Hongmei, Yuan Xiaofan, Zhang Shaoru, and Qin Xinyue. "Exploring the potential mechanism of Fritiliariae Irrhosae Bulbus on ischemic stroke based on network pharmacology and experimental validation." Frontiers in Pharmacology 13 (November 17, 2022). http://dx.doi.org/10.3389/fphar.2022.1049586.

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Objective: To study the potential targets and molecular mechanisms of Fritiliariae Irrhosae Bulbus (FIB) in the treatment of ischemic strokes based on a network pharmacology strategy, with a combination of molecular docking and animal experiments.Methods: The active components and targets of FIB were screened by TCMSP database and TCMIP database, and the related targets of ischemic strokes were screened by GeneCards, OMIM, CTD, and DrugBank, then the intersection targets of the two were taken. The protein interaction network was constructed by STRING, the PPI network diagram was drawn by using

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Demine, Stéphane, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, and Decio L. Eizirik. "Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells." Stem Cell Research & Therapy 11, no. 1 (2020). http://dx.doi.org/10.1186/s13287-019-1523-3.

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Abstract Background Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently taken place to differentiate beta cells from human induced pluripotent stem cells (iPSCs) and validate their use for diabetes research. We presently used a 7-stage protocol to generate beta cells from human iPSC and evaluated whether these cells are responsive to the pro-inflammatory cytokines (IFNγ, IL-1β, or IFNα) that play a role in type 1 diabetes. Methods The iPSC-der

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Espinoza, Keila, Marilyn Marron, Justin Snider, and Ashley Snider. "Loss of Acid Ceramidase in Myeloid Cells Impairs MHC II Expression on Dendritic Cells and Macrophages to Alleviate Chronic Colitis in IL10^−/− Mice." Physiology 39, S1 (2024). http://dx.doi.org/10.1152/physiol.2024.39.s1.730.

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Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the colon and drastically increases the risk in the development of colorectal cancer (CRC). Over expression of acid ceramidase (AC) resulting in accumulation of sphingosine-1-phosphate (S1P), which amplify inflammatory pathways, has been implicated in patients with IBD and CRC. The conditional loss of AC in myeloid cells (ACMYE) has demonstrated promise as a therapeutic target in an acute colitis model. We sought to expand the investigation of AC loss in a physiologically relevant model of IBD using IL-10 deficient mi

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Xing, Ying, Bofan Lin, Baoxinzi Liu, Jie Shao, and Zhichao Jin. "Tectorigenin Inhibits Glycolysis-induced Cell Growth and Proliferation by Modulating LncRNA CCAT2/miR-145 Pathway in Colorectal Cancer." Current Cancer Drug Targets 24 (January 11, 2024). http://dx.doi.org/10.2174/0115680096274757231219072003.

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Background: Colorectal cancer (CRC) places a heavy burden on global health. Tectorigenin (Tec) is a type of flavonoid-based compound obtained from the Chinese medical herb Leopard Lily Rhizome. It was found to exhibit remarkable anti-tumor properties in previous studies. However, the effect and molecular mechanisms of Tec in colorectal cancer have not been reported. Objective: The objective of this study was to explore the action of Tec in proliferation and glycolysis in CRC and the potential mechanism with regard to the long non-coding RNA (lncRNA) CCAT2/micro RNA-145(miR-145) pathway in vitr

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