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Journal articles on the topic 'Récepteurs au glutamate de type NMDA'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Portal, Benjamin, and Bruno P. Guiard. "Rôle des connexines astrocytaires dans la régulation des taux extracellulaires de glutamate : implication pour le traitement des épisodes dépressifs majeurs." Biologie Aujourd’hui 214, no. 3-4 (2020): 71–83. http://dx.doi.org/10.1051/jbio/2020008.

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La dépression majeure est une pathologie psychiatrique reposant sur différents mécanismes neurobiologiques. Parmi ces mécanismes, on trouve une hypersensibilité de l’axe hypothalamo-hypophyso-surrénalien associée à un excès de cortisol dans le sang et un déficit de neurotransmission monoaminergique. Ainsi, l’efficacité thérapeutique des antidépresseurs actuels repose sur leur capacité à augmenter les taux extracellulaires de monoamines dans la fente synaptique. Depuis la découverte des effets antidépresseurs rapides et durables de la kétamine, un antagoniste des récepteurs NMDA, un intérêt cro

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Oliet, Stéphane H. R., and Thomas Papouin. "De l’importance de la localisation des récepteurs du glutamate NMDA." médecine/sciences 29, no. 3 (2013): 260–62. http://dx.doi.org/10.1051/medsci/2013293011.

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3

Peschanski, M. "Les récepteurs-NMDA du glutamate permettent le modelage du système nerveux." médecine/sciences 10, no. 6-7 (1994): 722. http://dx.doi.org/10.4267/10608/2694.

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4

Platel, Jean-Claude, and Angélique Bordey. "Rôle des récepteurs NMDA et du glutamate astrocytaire dans la neurogenèse postnatale." médecine/sciences 26, no. 8-9 (2010): 675–77. http://dx.doi.org/10.1051/medsci/2010268-9675.

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Hamon, M. "Bases neurobiologiques des traitements de l’alcoolo-dépendance – Quelles perspectives ?" European Psychiatry 29, S3 (2014): 539. http://dx.doi.org/10.1016/j.eurpsy.2014.09.411.

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Contrairement aux autres produits addictogènes qui agissent via des cibles spécifiques (récepteurs opiacés pour l’héroïne, récepteur cannabinoïde CB1 pour le cannabis, récepteurs nicotiniques pour le tabac, transporteurs des monoamines pour la cocaïne), l’alcool ne se fixe pas sur une cible en particulier, mais intervient à de multiples niveaux, enzymatiques, réceptoriels, etc., dans le cerveau. Certes, comme celle des autres produits addictogènes, la prise d’alcool entraîne une activation du système de récompense (reward system), et donc la libération de dopamine au niveau des projections de

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Takahashi, Yukitoshi, Etsuko Yamazaki, Shigeko Nishimura, et al. "Acute limbic encephalitis and NMDA type-glutamate receptor." Rinsho Shinkeigaku 48, no. 11 (2008): 926–29. http://dx.doi.org/10.5692/clinicalneurol.48.926.

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7

Feinstein, N., D. Parnas, H. Parnas, J. Dudel, and I. Parnas. "Functional and Immunocytochemical Identification of Glutamate Autoreceptors of an NMDA Type in Crayfish Neuromuscular Junction." Journal of Neurophysiology 80, no. 6 (1998): 2893–99. http://dx.doi.org/10.1152/jn.1998.80.6.2893.

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Feinstein, N., D. Parnas, H. Parnas, J. Dudel, and I. Parnas. Functional and immunocytochemical identification of glutamate autoreceptors of an NMDA type in crayfish neuromuscular junction. J. Neurophysiol. 80: 2893–2899, 1998. N-Methyl-d-aspartate (NMDA) reduces release from crayfish excitatory nerve terminals. We show here that polyclonal and monoclonal antibodies raised against the mammalian postsynaptic NMDA receptor subunit 1 stain specifically the presynaptic membrane of release boutons of the crayfish neuromuscular junction. In crayfish ganglionic membranes, the polyclonal antibody reco

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Flores-Soto, M. E., V. Chaparro-Huerta, M. Escoto-Delgadillo, E. Vazquez-Valls, R. E. González-Castañeda, and C. Beas-Zarate. "Structure and function of NMDA-type glutamate receptor subunits." Neurología (English Edition) 27, no. 5 (2012): 301–10. http://dx.doi.org/10.1016/j.nrleng.2011.10.003.

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9

Barria, Andres. "Trafficking, regulation, and function of NMDA-type glutamate receptors." Neuroscience Research 65 (January 2009): S28. http://dx.doi.org/10.1016/j.neures.2009.09.1654.

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10

Spencer, Gary J., Catherine J. McGrath, and Paul G. Genever. "Current perspectives on NMDA-type glutamate signalling in bone." International Journal of Biochemistry & Cell Biology 39, no. 6 (2007): 1089–104. http://dx.doi.org/10.1016/j.biocel.2006.11.002.

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11

Lapeikaite, Indre, Vilmantas Pupkis, Vladas Neniskis, Osvaldas Ruksenas, and Vilma Kisnieriene. "Glutamate and NMDA affect cell excitability and action potential dynamics of single cell of macrophyte Nitellopsis obtusa." Functional Plant Biology 47, no. 12 (2020): 1032. http://dx.doi.org/10.1071/fp20074.

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The effect of glutamate and N-methyl-d-aspartate (NMDA) on electrical signalling – action potentials (AP) and excitation current transients – was studied in intact macrophyte Nitellopsis obtusa (Characeaen) internodal cell. Intracellular glass electrode recordings of single cell in current clamp and two-electrode voltage clamp modes indicate that glutamate (Glu, 0.1–1.0 mM) and NMDA (0.01–1.0 mM) increase electrically induced AP amplitude by hyperpolarising excitation threshold potential (Eth) and prolong AP fast repolarisation phase. Amplitude of Cl– current transient, as well as its activati

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Haak, Laurel L. "Metabotropic Glutamate Receptor Modulation of Glutamate Responses in the Suprachiasmatic Nucleus." Journal of Neurophysiology 81, no. 3 (1999): 1308–17. http://dx.doi.org/10.1152/jn.1999.81.3.1308.

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Metabotropic glutamate receptor modulation of glutamate responses in the suprachiasmatic nucleus. Glutamate is the primary excitatory transmitter in the suprachiasmatic nucleus (SCN). Ionotropic glutamate receptors (iGluRs) mediate transduction of light information from the retina to the SCN, an important circadian clock phase shifting pathway. Metabotropic glutamate receptors (mGluRs) may play a significant modulatory role. mGluR modulation of SCN responses to glutamate was investigated with fura-2 calcium imaging in SCN explant cultures. SCN neurons showed reproducible calcium responses to g

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13

Mori, Hisashi. "Regulation of NMDA-type glutamate receptor by endogenous d-serine." Neuroscience Research 65 (January 2009): S9. http://dx.doi.org/10.1016/j.neures.2009.09.1520.

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14

Fuziwara, Shigeyoshi, Kaori Inoue, and Mitsuhiro Denda. "NMDA-Type Glutamate Receptor Is Associated with Cutaneous Barrier Homeostasis." Journal of Investigative Dermatology 120, no. 6 (2003): 1023–29. http://dx.doi.org/10.1046/j.1523-1747.2003.12238.x.

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15

Wright, Jason, Carlos Campos, Thiebaut Herzog, Mihai Covasa, Krzysztof Czaja, and Robert C. Ritter. "Reduction of food intake by cholecystokinin requires activation of hindbrain NMDA-type glutamate receptors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 301, no. 2 (2011): R448—R455. http://dx.doi.org/10.1152/ajpregu.00026.2011.

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Intraperitoneal injection of CCK reduces food intake and triggers a behavioral pattern similar to natural satiation. Reduction of food intake by CCK is mediated by vagal afferents that innervate the stomach and small intestine. These afferents synapse in the hindbrain nucleus of the solitary tract (NTS) where gastrointestinal satiation signals are processed. Previously, we demonstrated that intraperitoneal (IP) administration of either competitive or noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists attenuates reduction of food intake by CCK. However, because vagal afferents them

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Cairns, Brian E., Peter Svensson, Kelun Wang, et al. "Activation of Peripheral NMDA Receptors Contributes to Human Pain and Rat Afferent Discharges Evoked by Injection of Glutamate into the Masseter Muscle." Journal of Neurophysiology 90, no. 4 (2003): 2098–105. http://dx.doi.org/10.1152/jn.00353.2003.

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Peripheral N-methyl-d-aspartate (NMDA) receptors are found in deep tissues and may play a role in deep tissue pain. Injection of the endogenous NMDA receptor agonist glutamate into the masseter muscle excites deep craniofacial afferent fibers in rats and evokes pain in human subjects. It is not clear whether peripheral NMDA receptors play a role in these effects of glutamate. Accordingly, the effect of NMDA on afferent activity as well as the effect of locally administered NMDA receptor antagonists on glutamate-evoked afferent discharges in acutely anesthetized rats and muscle pain in human su

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Eliasof, Scott, and Craig E. Jahr. "Rapid AMPA receptor desensitization in catfish cone horizontal cells." Visual Neuroscience 14, no. 1 (1997): 13–18. http://dx.doi.org/10.1017/s0952523800008713.

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AbstractAMPA and NMDA type glutamate receptors were studied in isolated catfish cone horizontal cells using the whole-cell and outside-out patch-recording techniques. In whole-cell recordings, cyclothiazide (CTZ) enhanced the peak current in response to glutamate (in the presence of NMDA receptor antagonists). In patch recordings, currents evoked by rapid and maintained applications of glutamate desensitized with a time constant of one millisecond. CTZ blocked this rapid desensitization. Recovery from desensitization of the AMPA receptors was rapid, having a time constant of 8.65 ms. In contra

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Lu, Shao-Ming, Nada Zecevic, and Hermes H. Yeh. "Distinct NMDA and AMPA Receptor–Mediated Responses in Mouse and Human Cajal-Retzius Cells." Journal of Neurophysiology 86, no. 5 (2001): 2642–46. http://dx.doi.org/10.1152/jn.2001.86.5.2642.

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This study examined glutamate-activated current responses of mouse and human Cajal-Retzius (C-R) cells. Thin cortical slices were prepared from the brains of mice 4–6 days after birth and from those of midgestational human fetuses. Both human and mouse C-R cells displayed glutamate-induced whole-cell current responses that were voltage-dependent and included an N-methyl-d-aspartate (NMDA) receptor–mediated component that was differentially sensitive to blockade by the NMDA receptor antagonists 2-amino-5-phosphonovaleric acid and ifenprodil. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

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19

Nagele, Peter, Laura B. Metz, and C. Michael Crowder. "Xenon Acts by Inhibition of Non–N -methyl-d-aspartate Receptor–mediated Glutamatergic Neurotransmission in Caenorhabditis elegans." Anesthesiology 103, no. 3 (2005): 508–13. http://dx.doi.org/10.1097/00000542-200509000-00013.

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Background Electrophysiologic experiments in rodents have found that nitrous oxide and xenon inhibit N-methyl-D-aspartate (NMDA)-type glutamate receptors. These findings led to the hypothesis that xenon and nitrous oxide along with ketamine form a class of anesthetics with the identical mechanism, NMDA receptor antagonism. Here, the authors ask in Caenorhabditis elegans whether xenon, like nitrous oxide, acts by a NMDA receptor-mediated mechanism. Methods Xenon:oxygen mixtures were delivered into sealed chambers until the desired concentration was achieved. The effects of xenon on various beha

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20

Leinders-Zufall, T., M. N. Rand, S. G. Waxman, and J. D. Kocsis. "Differential role of two Ca(2+)-permeable non-NMDA glutamate channels in rat retinal ganglion cells: kainate-induced cytoplasmic and nuclear Ca2+ signals." Journal of Neurophysiology 72, no. 5 (1994): 2503–16. http://dx.doi.org/10.1152/jn.1994.72.5.2503.

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1. The permeability of non-N-methyl-D-aspartate (non-NMDA) glutamate channels to divalent cations and specifically the entry of Ca2+ and subsequent elevations in cytoplasmic and nuclear Ca2+ signals were investigated in cultured neonatal rat retinal ganglion cells using the whole cell patch-clamp technique and Ca2+ imaging with confocal microscopy. In addition, divalent-permeable non-NMDA receptor channels were studied in retinal slices using a Co2+ staining technique. 2. Using Ca2+ (2.5 mM) as the only permeable cation in the external solution, stimulation with 100 microM kainate produced non

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21

Verderio, C., S. Coco, G. Fumagalli, and M. Matteoli. "Spatial changes in calcium signaling during the establishment of neuronal polarity and synaptogenesis." Journal of Cell Biology 126, no. 6 (1994): 1527–36. http://dx.doi.org/10.1083/jcb.126.6.1527.

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Calcium imaging techniques were used to obtain a clear although indirect evidence about the distribution of functional glutamate receptors of NMDA and non-NMDA type in cultured hippocampal neurons during establishment of polarity and synaptogenesis. Glutamate receptors were expressed and were already functional as early as one day after plating. At this stage NMDA and non-NMDA receptors were distributed in all plasmalemmal areas. During the establishment of neuronal polarity, responses to either types of glutamate receptors became restricted to the soma and dendrites. Compartmentalization of g

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Lin, Bin, Amy C. Arai, Gary Lynch, and Christine M. Gall. "Integrins Regulate NMDA Receptor-Mediated Synaptic Currents." Journal of Neurophysiology 89, no. 5 (2003): 2874–78. http://dx.doi.org/10.1152/jn.00783.2002.

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Synapses contain high concentrations of integrins, adhesion receptors known to influence the operation of neighboring transmembrane proteins. Evidence that integrins are important for consolidation of long-term potentiation suggests that these adhesion proteins may modulate activities of synaptic glutamate receptors. The present study provides a first test of the possibility that integrins modulate synaptic N-methyl-d-aspartate (NMDA)-type glutamate receptor activities. Excitatory postsynaptic currents (EPSCs) were recorded with whole cell clamp from hippocampal slices in which AMPA-type gluta

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Genever, Paul G., David J. P. Wilkinson, Amanda J. Patton, et al. "Expression of a Functional N-Methyl-d-Aspartate–Type Glutamate Receptor by Bone Marrow Megakaryocytes." Blood 93, no. 9 (1999): 2876–83. http://dx.doi.org/10.1182/blood.v93.9.2876.

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Abstract Better understanding of hemostasis will be possible by the identification of new lineage-specific stimuli that regulate platelet formation. We describe a novel functional megakaryocyte receptor that belongs to a family of ionotropic glutamate receptors of theN-methyl-d-aspartate (NMDA) subtype responsible for synaptic neurotransmission in the central nervous system (CNS). Northern blotting and reverse-transcriptase polymerase chain reaction (RT-PCR) studies identified expression of NMDAR1 and NMDAR2D type subunit mRNA in rat marrow, human megakaryocytes, and MEG-01 clonal megakaryobla

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Genever, Paul G., David J. P. Wilkinson, Amanda J. Patton, et al. "Expression of a Functional N-Methyl-d-Aspartate–Type Glutamate Receptor by Bone Marrow Megakaryocytes." Blood 93, no. 9 (1999): 2876–83. http://dx.doi.org/10.1182/blood.v93.9.2876.409k31_2876_2883.

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Better understanding of hemostasis will be possible by the identification of new lineage-specific stimuli that regulate platelet formation. We describe a novel functional megakaryocyte receptor that belongs to a family of ionotropic glutamate receptors of theN-methyl-d-aspartate (NMDA) subtype responsible for synaptic neurotransmission in the central nervous system (CNS). Northern blotting and reverse-transcriptase polymerase chain reaction (RT-PCR) studies identified expression of NMDAR1 and NMDAR2D type subunit mRNA in rat marrow, human megakaryocytes, and MEG-01 clonal megakaryoblastic cell

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Parfenova, Helena, Dilyara Tcheranova, Shyamali Basuroy, Alexander L. Fedinec, Jianxiong Liu, and Charles W. Leffler. "Functional role of astrocyte glutamate receptors and carbon monoxide in cerebral vasodilation response to glutamate." American Journal of Physiology-Heart and Circulatory Physiology 302, no. 11 (2012): H2257—H2266. http://dx.doi.org/10.1152/ajpheart.01011.2011.

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In newborn pigs, vasodilation of pial arterioles in response to glutamate is mediated via carbon monoxide (CO), a gaseous messenger endogenously produced from heme degradation by a heme oxygenase (HO)-catalyzed reaction. We addressed the hypothesis that ionotropic glutamate receptors (iGluRs), including N-methyl-d-aspartic acid (NMDA)- and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid (AMPA)/kainate-type receptors, expressed in cortical astrocytes mediate glutamate-induced astrocyte HO activation that leads to cerebral vasodilation. Acute vasoactive effects of topical iGluR agonist

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Bach, Eva C., and Bret N. Smith. "Presynaptic NMDA receptor-mediated modulation of excitatory neurotransmission in the mouse dorsal motor nucleus of the vagus." Journal of Neurophysiology 108, no. 5 (2012): 1484–91. http://dx.doi.org/10.1152/jn.01036.2011.

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Activity of neurons in the dorsal motor nucleus of the vagus nerve (DMV) is closely regulated by synaptic input, and regulation of that input by glutamate receptors on presynaptic terminals has been proposed. Presynaptic N-methyl-d-aspartic acid (NMDA) receptors have been identified in a number of brain regions and act to modulate neurotransmitter release, but functional presynaptic NMDA receptors have not been adequately studied in the DMV. This study identified the presence and physiological function of presynaptic NMDA receptors on synaptic input to DMV neurons. Whole-cell patch-clamp recor

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Brierley, M. J., M. S. Yeoman, and P. R. Benjamin. "Glutamate is the Transmitter for N2v Retraction Phase Interneurons of the Lymnaea Feeding System." Journal of Neurophysiology 78, no. 6 (1997): 3408–14. http://dx.doi.org/10.1152/jn.1997.78.6.3408.

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Brierley, Matthew J., Mark S. Yeoman, and Paul R. Benjamin. Glutamate is the transmitter for the N2v retraction phase interneurons of the Lymnaea feeding system. J. Neurophysiol. 78: 3408–3414, 1997. Electrophysiological and pharmacological methods were used to examine the role of glutamate in mediating the excitatory and inhibitory responses produced by the N2v rasp phase neurons on postsynaptic cells of the Lymnaea feeding network. The N2v → B3 motor neuron excitatory synaptic response could be mimicked by focal or bath application of l-glutamate at concentrations of ≥10−3 M. Quisqualate and

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Dubois, Christophe J., Philippe M. Lachamp, Lu Sun, Masayoshi Mishina, and Siqiong June Liu. "Presynaptic GluN2D receptors detect glutamate spillover and regulate cerebellar GABA release." Journal of Neurophysiology 115, no. 1 (2016): 271–85. http://dx.doi.org/10.1152/jn.00687.2015.

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Glutamate directly activates N-methyl-d-aspartate (NMDA) receptors on presynaptic inhibitory interneurons and enhances GABA release, altering the excitatory-inhibitory balance within a neuronal circuit. However, which class of NMDA receptors is involved in the detection of glutamate spillover is not known. GluN2D subunit-containing NMDA receptors are ideal candidates as they exhibit a high affinity for glutamate. We now show that cerebellar stellate cells express both GluN2B and GluN2D NMDA receptor subunits. Genetic deletion of GluN2D subunits prevented a physiologically relevant, stimulation

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Harris, Michael B., and William K. Milsom. "Apneusis follows disruption of NMDA-type glutamate receptors in vagotomized ground squirrels." Respiratory Physiology & Neurobiology 134, no. 3 (2003): 191–207. http://dx.doi.org/10.1016/s1569-9048(02)00223-9.

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Kano, Takashi, Penelope J. Brockie, Toshihiro Sassa, et al. "Memory in Caenorhabditis elegans Is Mediated by NMDA-Type Ionotropic Glutamate Receptors." Current Biology 18, no. 13 (2008): 1010–15. http://dx.doi.org/10.1016/j.cub.2008.05.051.

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Dumas, Sébastien J., Gilles Bru-Mercier, Audrey Courboulin, et al. "NMDA-Type Glutamate Receptor Activation Promotes Vascular Remodeling and Pulmonary Arterial Hypertension." Circulation 137, no. 22 (2018): 2371–89. http://dx.doi.org/10.1161/circulationaha.117.029930.

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Marcaida, Goizane, Vicente Felipo, Carlos Hermenegildo, Maria-Dolores Miñana, and Santiago Grisolia. "Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors." FEBS Letters 296, no. 1 (1992): 67–68. http://dx.doi.org/10.1016/0014-5793(92)80404-5.

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Jin, Qing-Hua, Yuto Ueda, Yuta Ishizuka, Takato Kunitake, and Hiroshi Kannan. "Cardiovascular changes induced by central hypertonic saline are accompanied by glutamate release in awake rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 281, no. 4 (2001): R1224—R1231. http://dx.doi.org/10.1152/ajpregu.2001.281.4.r1224.

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To elucidate neurochemical mechanisms responsible for cardiovascular responses induced by central salt loading, we directly perfused the paraventricular nucleus (PVN) of the hypothalamus region with hypertonic saline (0.3 or 0.45 M) by using an in vivo brain microdialysis technique. We then measured the extracellular concentrations of glutamate in the PVN region in conscious rats along with the blood pressure and heart rate. Blood pressure, heart rate, and glutamate levels were increased by perfusion of 0.45 M saline; however, they did not change by perfusion of 0.3 M saline. Next, we examined

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Proskurina, S. E., K. A. Petrov, and E. E. Nikolsky. "Influence of the Activation of NMDA Receptors on the Resting Membrane Potential of the Postsynaptic Cell at the Neuromuscular Junction." Acta Naturae 10, no. 3 (2018): 100–102. http://dx.doi.org/10.32607/20758251-2018-10-3-100-102.

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Impaired function or insufficient expression of glutamate N-methyl-D-aspartate (NMDA) receptors underlies a number of brain pathologies; these receptors are, therefore, regarded as a pharmacological target for many neuroactive drugs. It was shown that in the CNS, this type of glutamate receptors participate in the processes of neuronal excitation, synaptic plasticity [1, 2], and excitotoxicity in neurodegenerative diseases and are also involved in the pathogenesis of epilepsy and seizures. However, until recently, the presence and activity of NMDA receptors beyond the CNS had never been consid

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Iskra, D. A., V. Yu Lobzin, and S. A. Kalygin. "Primary headaches and cognitive disorders — pathophysiologically associated and comorbidity conditions." V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, no. 2 (November 11, 2018): 97–103. http://dx.doi.org/10.31363/2313-7053-2018-2-97-103.

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Primary headaches (migraine, tension-type headache and other primary headaches) cause 3% of all disability cases in adult population, fully decrease possibilities of social functioning. Te phenomenon of the central sensitization is one of the fundamental pathophysiological units of primary headaches. NMDA receptors are involved both in initiation and in maintaining of mechanisms of a long-term central sensitization. NMDA activation by glutamate play important role in the initiation of primary headaches. Cognitive impairment development also conducted with NMDA-excitotoxicity due to hyper excit

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Nandakumar, DN, P. Ramaswamy, C. Prasad, D. Srinivas, and K. Goswami. "Glioblastoma invasion and NMDA receptors: A novel prospect." Physiology International 106, no. 3 (2019): 250–60. http://dx.doi.org/10.1556/2060.106.2019.22.

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Purpose Glioblastoma cells create glutamate-rich tumor microenvironment, which initiates activation of ion channels and modulates downstream intracellular signaling. N-methyl-D-aspartate receptors (NMDARs; a type of glutamate receptors) have a high affinity for glutamate. The role of NMDAR activation on invasion of glioblastoma cells and the crosstalk with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is yet to be explored. Main methods LN18, U251MG, and patient-derived glioblastoma cells were stimulated with NMDA to activate NMDAR glutamate receptors. The role of NMD

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Bellinger, Frederick P., Bradley K. Fox, Wing Yan Chan, et al. "Ionotropic glutamate receptor activation increases intracellular calcium in prolactin-releasing cells of the adenohypophysis." American Journal of Physiology-Endocrinology and Metabolism 291, no. 6 (2006): E1188—E1196. http://dx.doi.org/10.1152/ajpendo.00207.2005.

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Endocrine cells of the anterior pituitary are controlled by the central nervous system through hormonal interactions and are not believed to receive direct synaptic connections from the brain. Studies suggest that some pituitary cells may be modulated by the neurotransmitter glutamate ( 5 , 16 ). We investigated prolactin (PRL)-releasing cells of the anterior pituitary of a euryhaline fish, the tilapia ( Oreochromis mossambicus), for the presence of possible glutamate receptors (GluRs). Fura-2 imaging addressed the ability of glutamate to increase intracellular calcium. We observed a dose-depe

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Evans, P. D., V. Reale, R. M. Merzon, and J. Villegas. "N-methyl-D-aspartate (NMDA) and non-NMDA (metabotropic) type glutamate receptors modulate the membrane potential of the Schwann cell of the squid giant nerve fibre." Journal of Experimental Biology 173, no. 1 (1992): 229–49. http://dx.doi.org/10.1242/jeb.173.1.229.

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L-Glutamate application can produce three different responses in the membrane potential of the Schwann cell of the tropical squid, Sepioteuthis sepioidea, which appear to be mediated by three pharmacologically distinct classes of receptor. A class of non-NMDA-type receptors, with some similarities to metabotropic glutamate receptors, mediates the development of a rapid and long-lasting hyperpolarization. Two pharmacologically distinct classes of NMDA-type receptor are present. One mediates the development of a slow depolarization accompanied by a long-lasting change in responsiveness of the Sc

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Takizawa, Shunya, Kazushi Matsushima, Hitoshi Fujita, Kazunori Nanri, Saori Ogawa, and Yukito Shinohara. "A Selective N-Type Calcium Channel Antagonist Reduces Extracellular Glutamate Release and Infarct Volume in Focal Cerebral Ischemia." Journal of Cerebral Blood Flow & Metabolism 15, no. 4 (1995): 611–18. http://dx.doi.org/10.1038/jcbfm.1995.75.

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Although a number of studies have demonstrated the neuroprotective effects of antagonists of postsynaptic N-methyl-d-aspartate (NMDA) and non-NMDA receptors in cerebral ischemia, little is known about the treatment of cerebral infarction through presynaptic blocking of extracellular glutamate release. We evaluated the effects of a presynaptic selective N-type calcium channel antagonist (SNX-111, given intravenously by continuous infusion at 5 mg/kg/h from 20 min prior to occlusion until 2 h postocclusion) on blood flow, extracellular glutamate, and infarct volume in rats with permanent occlusi

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Budreck, E. C., O. B. Kwon, J. H. Jung, et al. "Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling." Proceedings of the National Academy of Sciences 110, no. 2 (2012): 725–30. http://dx.doi.org/10.1073/pnas.1214718110.

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Lovinger, David M., and Walter Zieglgansberger. "Interactions between Ethanol and Agents that Act on the NMDA-Type Glutamate Receptor." Alcoholism: Clinical and Experimental Research 20, s8 (1996): 187a—191a. http://dx.doi.org/10.1111/j.1530-0277.1996.tb01773.x.

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Williams, N., R. Roberts, and S. Daniels. "The action of mephenesin and benzimidazole at glycine and NMDA-type glutamate receptors." European Journal of Pharmaceutical Sciences 4 (September 1996): S53. http://dx.doi.org/10.1016/s0928-0987(97)86202-1.

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Evans, PD, V. Reale, RM Merzon, and J. Villegas. "N-methyl-D-aspartate (NMDA) and non-NMDA type glutamate receptors are present on squid giant axon Schwann cells." Journal of Experimental Biology 157, no. 1 (1991): 593–600. http://dx.doi.org/10.1242/jeb.157.1.593.

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Ishida, M., Y. Ohfune, Y. Shimada, K. Shimamoto, and H. Shinozaki. "Changes in preference for receptor subtypes of configurational variants of a glutamate analog: Conversion from the NMDA-type to the non-NMDA type." Brain Research 550, no. 1 (1991): 152–56. http://dx.doi.org/10.1016/0006-8993(91)90420-z.

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Eklove, Harley, and Rodney A. Webb. "The effect of L-glutamate and related agents on adenylate cyclase in the cestode Hymenolepis diminuta." Canadian Journal of Physiology and Pharmacology 69, no. 1 (1991): 28–36. http://dx.doi.org/10.1139/y91-005.

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The effect of the putative amino acid transmitter, L-glutamate, on adenylate cyclase in crude membrane preparations of the rat tapeworm Hymenolepis diminuta was investigated to determine if glutamate effects the generation of the second messenger cAMP. Addition of glutamate at 10−3 and 5.5 × 10−9 M resulted in significant elevations in basal activity of adenylate cyclase, while concentrations in the 10−5–10−7 M range caused significant depressions below basal activity. Assays with glutamate agonists and other acidic compounds showed glutamate to be the only amino acid, dicarboxylic acid, or ac

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Shkryl, V. M., V. V. Ganzha та E. A. Lukyanetz. "Effect of memantine on calcium signaling in hippocampal neurons cultured with β-amyloid". Fiziolohichnyĭ zhurnal 67, № 2 (2021): 3–10. http://dx.doi.org/10.15407/fz67.02.003.

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Alzheimer’s disease (AD) is the most common type of dementia and is characterized by accumulating amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Excessive stimulation of glutamate receptors, mainly NMDA-type, causes intense entry of calcium ions into cells and is a key early step in glutamateinduced excitotoxicity, resulting in many neurological diseases, including AD. Memantine, an NMDA receptor antagonist, blocks NMDA receptors and reduce the influx of calcium ions into neuron. In our experiments, we have modeled AD on cultured rat hippocampal neurons to test the effects of m

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Wilhelm, Stefan, Daqing Ma, Mervyn Maze, and Nicholas P. Franks. "Effects of Xenon on In Vitro and In Vivo Models of Neuronal Injury." Anesthesiology 96, no. 6 (2002): 1485–91. http://dx.doi.org/10.1097/00000542-200206000-00031.

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Background Xenon, the "inert" gaseous anesthetic, is an antagonist at the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Because of the pivotal role that NMDA receptors play in neuronal injury, the authors investigated the efficacy of xenon as a neuroprotectant in both in vitro and in vivo paradigms. Methods In a mouse neuronal-glial cell coculture, injury was provoked either by NMDA, glutamate, or oxygen deprivation and assessed by the release of lactate dehydrogenase into the culture medium. Increasing concentrations of either xenon or nitrogen (10-75% of an atmosphere) were coadminist

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KALLONIATIS, MICHAEL, DANIEL SUN, LISA FOSTER, SILKE HAVERKAMP, and HEINZ WÄSSLE. "Localization of NMDA receptor subunits and mapping NMDA drive within the mammalian retina." Visual Neuroscience 21, no. 4 (2004): 587–97. http://dx.doi.org/10.1017/s0952523804214080.

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Glutamate is a major neurotransmitter in the retina and other parts of the central nervous system, exerting its influence through ionotropic and metabotropic receptors. One ionotropic receptor, the N-methyl-D-aspartate (NMDA) receptor, is central to neural shaping, but also plays a major role during neuronal development and in disease processes. We studied the distribution pattern of different subunits of the NMDA receptor within the rat retina including quantifying the pattern of labelling for all the NR1 splice variants, the NR2A and NR2B subunits. The labelling pattern for the subunits was

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Evans, P. D., V. Reale, R. M. Merzon, and J. Villegas. "The effect of a glutamate uptake inhibitor on axon-Schwann cell signalling in the squid giant nerve fibre." Journal of Experimental Biology 173, no. 1 (1992): 251–60. http://dx.doi.org/10.1242/jeb.173.1.251.

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The glutamate uptake blocker p-chloromercuriphenylsulphonic acid (PCMS) (100 mumol l-1) does not block any of the membrane potential changes induced by the application of L-glutamate to the adaxonal Schwann cells of the giant axon of the tropical squid Sepioteuthis sepioidea. This indicates that these potential changes are not due to the activation of an electrogenic glutamate uptake system and supports the idea that they are due to the activation of specific glutamate receptors. The presence of PCMS (100 mumol l-1) reduces the activity of the glutamate uptake system sufficiently for the extra

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Froger, Nicolas. "Potentialités thérapeutiques des neurostéroïdes en psychiatrie." Biologie Aujourd’hui 213, no. 3-4 (2019): 131–40. http://dx.doi.org/10.1051/jbio/2019023.

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Les neurostéroïdes constituent une famille de molécules synthétisées par le cerveau, représentée par les hormones stéroïdes elles-mêmes, mais également par certains de leurs précurseurs et métabolites. Ils ont des propriétés neuroactives en stimulant des voies de signalisation non génomiques, spécifiques des neurones. Trois types de neurostéroïdes ont été identifiés selon les voies qu’ils activent, à savoir (i) les neurostéroïdes inhibiteurs, (ii) les neurostéroïdes excitateurs et (iii) les neurostéroïdes microtubulaires. Les neurostéroïdes inhibiteurs activent les récepteurs ionotropiques GAB

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