Relevant bibliographies by topics / Receptor NOP

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Receptor NOP'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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Journal articles on the topic "Receptor NOP"

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Kiguchi, Norikazu, Huiping Ding, Shiroh Kishioka, and Mei-Chuan Ko. "Nociceptin/Orphanin FQ Peptide Receptor-Related Ligands as Novel Analgesics." Current Topics in Medicinal Chemistry 20, no. 31 (2020): 2878–88. http://dx.doi.org/10.2174/1568026620666200508082615.

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Despite similar distribution patterns and intracellular events observed in the nociceptin/ orphanin FQ peptide (NOP) receptor and other opioid receptors, NOP receptor activation displays unique pharmacological profiles. Several researchers have identified a variety of peptide and nonpeptide ligands to determine the functional roles of NOP receptor activation and observed that NOP receptor- related ligands exhibit pain modality-dependent pain processing. Importantly, NOP receptor activation results in anti-nociception and anti-hypersensitivity at the spinal and supraspinal levels regardless of
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Zhuo, Guan-Yu, Ming-Chi Chen, Tzu-Yu Lin, Shih-Ting Lin, Daniel Tzu-Li Chen та Cynthia Wei-Sheng Lee. "Opioid-Modulated Receptor Localization and Erk1/2 Phosphorylation in Cells Coexpressing μ-Opioid and Nociceptin Receptors". International Journal of Molecular Sciences 24, № 2 (2023): 1048. http://dx.doi.org/10.3390/ijms24021048.

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We attempted to examine the alterations elicited by opioids via coexpressed μ-opioid (MOP) and nociceptin/orphanin FQ (NOP) receptors for receptor localization and Erk1/2 (p44/42 MAPK) in human embryonic kidney (HEK) 293 cells. Through two-photon microscopy, the proximity of MOP and NOP receptors was verified by fluorescence resonance energy transfer (FRET), and morphine but not buprenorphine facilitated the process of MOP-NOP heterodimerization. Single-particle tracking (SPT) further revealed that morphine or buprenorphine hindered the movement of the MOP-NOP heterodimers. After exposure to m
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Bird, Mark F., Barbara Gallacher-Horley, John McDonald, et al. "In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells." PLOS ONE 17, no. 9 (2022): e0274080. http://dx.doi.org/10.1371/journal.pone.0274080.

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Sepsis is a dysregulated host response to infection that can cause widespread effects on other organs including cardiovascular depression, hypotension and organ failure. The receptor for Nociceptin/Orphanin FQ (N/OFQ), NOP is expressed on immune cells and these cells can release the peptide. Exogenous N/OFQ can dilate blood vessels and this peptide is increased in animal and human sepsis. We hypothesise that NOP receptors are present on vascular endothelial cells and therefore provide the target for released N/OFQ to cause vasodilation and hence hypotension. Using human umbilical vein endothel
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Bird, M. F., J. McDonald, B. Horley, et al. "MOP and NOP receptor interaction: Studies with a dual expression system and bivalent peptide ligands." PLOS ONE 17, no. 1 (2022): e0260880. http://dx.doi.org/10.1371/journal.pone.0260880.

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Opioids targeting mu;μ (MOP) receptors produce analgesia in the peri-operative period and palliative care. They also produce side effects including respiratory depression, tolerance/dependence and addiction. The N/OFQ opioid receptor (NOP) also produces analgesia but is devoid of the major MOP side effects. Evidence exists for MOP-NOP interaction and mixed MOP-NOP ligands produce analgesia with reduced side effects. We have generated a HEKMOP/NOP human expression system and used bivalent MOP-NOP and fluorescent ligands to (i) probe for receptor interaction and (ii) consequences of that interac
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Mann, Anika, Lionel Moulédous, Carine Froment, et al. "Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists." Science Signaling 12, no. 574 (2019): eaau8072. http://dx.doi.org/10.1126/scisignal.aau8072.

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Agonists of the nociceptin/orphanin FQ opioid peptide (NOP) receptor, a member of the opioid receptor family, are under active investigation as novel analgesics, but their modes of signaling are less well characterized than those of other members of the opioid receptor family. Therefore, we investigated whether different NOP receptor ligands showed differential signaling or functional selectivity at the NOP receptor. Using newly developed phosphosite-specific antibodies to the NOP receptor, we found that agonist-induced NOP receptor phosphorylation occurred primarily at four carboxyl-terminal
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Zaveri, Nurulain T., Faming Jiang, Cris Olsen, Willma E. Polgar, and Lawrence Toll. "Designing bifunctional NOP receptor–mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I." Bioorganic & Medicinal Chemistry Letters 23, no. 11 (2013): 3308–13. http://dx.doi.org/10.1016/j.bmcl.2013.03.101.

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Blair Journigan, V., Willma E. Polgar, Taline V. Khroyan, and Nurulain T. Zaveri. "Designing bifunctional NOP receptor–mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II." Bioorganic & Medicinal Chemistry 22, no. 8 (2014): 2508–16. http://dx.doi.org/10.1016/j.bmc.2014.02.047.

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Holanda, Victor A. D., Salvatore Pacifico, Joaquim Azevedo Neto, et al. "Modulation of the NOP receptor signaling affects resilience to acute stress." Journal of Psychopharmacology 33, no. 12 (2019): 1540–49. http://dx.doi.org/10.1177/0269881119864942.

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Background: The peptide nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are implicated in the modulation of emotional states. Previous human and rodent findings support NOP antagonists as antidepressants. However, the role played by the N/OFQ–NOP receptor system in resilience to stress is unclear. Aims: The present study investigated the effects of activation or blockade of NOP receptor signaling before exposure to acute stress. Methods: The behavioral effects of the administration before stress of the NOP agonists Ro 65-6570 (0.01–1 mg/kg) and MCOPPB (0.1–10 mg/kg), and the NOP antagoni
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Whiteside, G. T., M. Hummel, T. Knappenberger, et al. "0001 Activation of Nociceptin/Orphanin-FQ Peptide (NOP) Receptors Produces an Increase in Non-REM Sleep in Rats and Constitutes a Novel and Attractive Target for the Treatment of Insomnia." Sleep 43, Supplement_1 (2020): A1. http://dx.doi.org/10.1093/sleep/zsaa056.000.

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Abstract Introduction Treatments for insomnia have targeted GABA, histamine, serotonin, melatonin and orexin receptors. The nociceptin/orphanin-FQ peptide (NOP) receptor is widely expressed in the nervous system. High doses of NOP agonists administered systemically or locally into the CNS can result in sedation, however, the utility of targeting this receptor to treat insomnia has not been fully described. Methods V117957 is a recently described investigational oral, potent and selective NOP receptor partial agonist. We determined the brain Kp in whole brain and multiple sub-regions (50mg/kg)
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Margas, Wojciech, Khaled Sedeek та Victor Ruiz-Velasco. "Coupling Specificity of NOP Opioid Receptors to Pertussis-Toxin-Sensitive Gα Proteins in Adult Rat Stellate Ganglion Neurons Using Small Interference RNA". Journal of Neurophysiology 100, № 3 (2008): 1420–32. http://dx.doi.org/10.1152/jn.90405.2008.

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The opioid receptor-like 1 (NOP or ORL1) receptor is a G-protein-coupled receptor the endogenous ligand of which is the heptadecapeptide, nociceptin (Noc). NOP receptors are known to modulate pain processing at spinal, supraspinal, and peripheral levels. Previous work has demonstrated that NOP receptors inhibit N-type Ca2+ channel currents in rat sympathetic stellate ganglion (SG) neurons via pertussis toxin (PTX)-sensitive Gαi/o subunits. However, the identification of the specific Gα subunit that mediates the Ca2+ current modulation is unknown. The purpose of the present study was to examine
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Dissertations / Theses on the topic "Receptor NOP"

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AZEVEDO, NETO Joaquim Gonalves. "NOP and mu opioid receptors: novel ligands and therapeutic opportunities." Doctoral thesis, Università degli studi di Ferrara, 2021. http://hdl.handle.net/11392/2487852.

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The aim of the study was to characterize new ligands and study new therapeutic opportunities for the N / OFQ - NOP receptor and the classic opioid receptors. The NOP and opioid receptors are 7TM receptors coupled with inhibitory G proteins. These receptors control various biological functions, such as the transmission of pain and the modulation of emotional states. The pharmacological concept of functional selectivity (aka bias agonism) could be useful for amplifying beneficial actions and / or counteracting side effects. To study the potential of biased agonism, new molecules with a large pol
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MOLINARI, Stefano. "Nociceptin/orphanin FQ – NOP receptor system: novel genetic and pharmacological tools." Doctoral thesis, Università degli studi di Ferrara, 2012. http://hdl.handle.net/11392/2389416.

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The neuropeptide nociceptin/orphanin FQ (N/OFQ) selectively binds and activates the N/OFQ peptide (NOP) receptor. In cells expressing the NOP receptor N/OFQ inhibits cAMP accumulation and Ca2+ conductance and stimulates K+ currents. Via these mechanisms N/OFQ regulates several biological functions in the central nervous system (pain, locomotion, memory, emotional responses, food intake), as well as in the periphery (airways, cardiovascular, genitourinary and gastrointestinal systems). Several research tools including knockout mice and NOP selective agonists and antagonists have been devel
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FISCHETTI, Carmela. "NOCICEPTIN/ORPHANIN FQ RECEPTOR LIGANDS: PHARMACOLOGICAL STUDIES." Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2389221.

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The neuropeptide nociceptin/orphanin FQ (N/OFQ) selectively binds and activates the N/OFQ peptide (NOP) receptor. At cellular level N/OFQ inhibits cAMP accumulation and Ca2+ conductance and stimulates K+ currents. N/OFQ regulates several biological functions both at central (pain, locomotion, memory, emotional responses, food intake) and peripheral (airways, cardiovascular, genitourinary and gastrointestinal systems) sites. Potent and selective NOP ligands are now required for investigating the roles played by NOP receptors in pathophysiological studies and for firmly defining the therap
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CERLESI, Maria Camilla. "Pharmacological characterization of novel ligands acting as NOP/opioid receptor agonists." Doctoral thesis, Università degli studi di Ferrara, 2016. http://hdl.handle.net/11392/2403470.

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La famiglia dei recettori oppioidi comprende i classici recettori oppioidi, mu (MOP), delta (DOP) e kappa (KOP) ed un quarto membro, chiamato recettore NOP, identificato come il recettore del peptide endogeno nocicettina/orfanina FQ (N/OFQ). Proprio per la sua distinta farmacologia, il recettore NOP è indicato come un ramo non oppioide della famiglia dei recettori oppioidi. Nonostante l’uso di farmaci oppiacei come morfina o fentanil, selettivi principalmente per il recettore MOP, sia associato a diversi effetti collaterali, tra cui la depressione respiratoria, stipsi, la tolleranza e la respo
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MALFACINI, Davide. "Novel ligands and assays for nociceptin/orphanin FQ and classical opioid receptors." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2388991.

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The aim of the present study was twofold: pharmacologically characterize novel ligands and set-up and validate novel in vitro assays for nociceptin/orphanin FQ (N/OFQ) peptide (NOP) and classical opioid receptors. NOP and opioid receptors are 7TM receptors coupled with inhibitory G proteins; receptor activation leads to the inhibition of cAMP formation and calcium currents, and opening of potassium channels. Via these cellular inhibitory mechanisms, the N/OFQ – NOP receptor and classical opioid systems regulate a variety of biological functions both in the central nervous system and in the per
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Fernandes, Diego Alexandre da Cunha. "Efeito de ligantes do receptor NOP no modelo animal de mania induzido por metilfenidato." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br/handle/123456789/19497.

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ARCURI, Ludovico. "N/OFQ and the NOP receptor: a target with broad potential in Parkinson’s Disease." Doctoral thesis, Università degli studi di Ferrara, 2016. http://hdl.handle.net/11392/2403505.

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Il neuropeptide nocicettina/orfanina FQ (N / OFQ) ed il suo recettore (NOP) svolgono un ruolo patogenetico nella malattia di Parkinson (PD). Questo lavoro di tesi ha cercato di affrontare due questioni diverse e irrisolte legate al ruolo del sistema N/OFQ-NOP nel PD. Il primo, e forse più rilevante, è se N/OFQ endogena contribuisca alla morte dei neuroni dopaminergici della substantia nigra compacta, il segno distintivo del PD. Utilizzando modelli genetici ed etologici di PD, siamo stati in grado di dimostrare che la rimozione genetica ed il blocco farmacologico del recettore NOP hanno un impa
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FERRARI, Federica. "Pharmacological profile of nociceptin/orphanin FQ receptor – characterization of novel peptide and non peptide ligands." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2478798.

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Il peptide nocicettina/orfanina FQ (N/OFQ) è il ligando endogeno del recettore NOP; questo sistema peptidergico controlla diverse funzioni biologiche sia nel sistema nervoso centrale che in periferia. Lo scopo del presente studio è stata la caratterizzazione farmacologica di nuovi ligandi peptidici e non-peptidici per il recettore NOP. Una serie di composti N/OFQ dimerici e l’antagonista PWT2-UFP-101 sono stati progettati e sintetizzati nella nostra Università, mentre i ligandi non-peptidici investigati provengono da case farmaceutiche. Tutti i composti sono stati valutati in vitro in diversi
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Philip, Ashok E. "Design, synthesis, molecular modeling, and biological evaluation of novel NOP (nociceptin/orphanin FQ peptide) receptor ligands /." Full text available from ProQuest UM Digital Dissertations, 2006. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1394651401&SrchMode=1&sid=2&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1216913414&clientId=22256.

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Gavioli, Elaine Cristina. "Participação do sistema nociceptina/orfanina fq-receptor nop na modulação da ansiedade e da depressão experimental." Florianópolis, SC, 2003. http://repositorio.ufsc.br/xmlui/handle/123456789/85920.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia<br>Made available in DSpace on 2012-10-21T01:17:06Z (GMT). No. of bitstreams: 1 199341.pdf: 976921 bytes, checksum: 9acbff52ed3709e69189fc23ed6ec0ff (MD5)<br>O presente trabalho estudou o papel da nociceptina (N/OFQ) e da nocistatina (NST) na modulação da ansiedade e da depressão experimental. Nossos dados mostraram que camundongos tratados com N/OFQ apresentaram um perfil do tipo ansiolítico no teste do labirinto em cruz elevado (LCE), enquanto que a NST induziu
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Books on the topic "Receptor NOP"

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Martin, Wehling, ed. Genomic and non-genomic effects of aldosterone. CRC Press, 1995.

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1929-, Shigeta Yukio, Kobayashi Masashi Dr, and Olefsky Jerrold M, eds. Recent advances in insulin action and its disorders: Proceedings of the International Symposium on Insulin Action and Its Disorders, Shiga, 16 May 1990. Excerpta Medica, 1991.

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Al-Hussary, Nabeel Ahmad Jargees. Insulin receptor binding in hypertension and non-insulin dependent diabetes mellitus. Aston University. Department of Molecular Sciences, 1986.

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1951-, Marescaux C., Vergnes M. 1935-, and Bernasconi R. 1929-, eds. Generalized non convulsive epilepsy: Focus on GABA-B receptors. Springer-Verlag, 1992.

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Marescaux, C., M. Vergnes, and R. Bernasconi, eds. Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors. Springer Vienna, 1992. http://dx.doi.org/10.1007/978-3-7091-9206-1.

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Cushen, Arthur T., Ashok Nallawalla, and Bryan D. Clark. Better Radio/TV Reception: A Non-Technical Approach. Ashley Publishing, 1986.

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Rossetti, Carlo, and Francesco Peri, eds. The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-56319-6.

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1950-, Chaudhuri Sukanta, and Lim Chee Seng, eds. Shakespeare without English: The reception of Shakespeare in non-anglophone countries. Pearson Education, 2006.

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G, Burger H., ed. Inhibin-non-steroidal regulation of follicle stimulating hormone secretion. Raven Press, 1987.

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Pharand, Chantal. The use of platelet glycoprotein IIB/IIIA receptor antagonists in the management of unstable angina and non-st-elevation myocardial infarction: A critical evaluation. s.n., 2000.

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Book chapters on the topic "Receptor NOP"

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Parker, Kyle E., and Michael R. Bruchas. "NOP Receptor Signaling Cascades." In Handbook of Experimental Pharmacology. Springer International Publishing, 2019. http://dx.doi.org/10.1007/164_2019_215.

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Mercatelli, Daniela, Clarissa Anna Pisanò, Salvatore Novello, and Michele Morari. "NOP Receptor Ligands and Parkinson’s Disease." In Handbook of Experimental Pharmacology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/164_2018_199.

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Malfacini, Davide, and Girolamo Caló. "Pharmacological Assays for Investigating the NOP Receptor." In Handbook of Experimental Pharmacology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/164_2018_200.

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Zaveri, Nurulain T., Dennis Yasuda, Blair V. Journigan, Pankaj R. Daga, Faming Jiang, and Cris Olsen. "Structure-Activity Relationships of Nociceptin Receptor (NOP) Ligands and the Design of Bifunctional NOP/Mu Opioid Receptor-Targeted Ligands." In ACS Symposium Series. American Chemical Society, 2013. http://dx.doi.org/10.1021/bk-2013-1131.ch008.

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Reinscheid, Rainer K., and Olivier Civelli. "The History of N/OFQ and the NOP Receptor." In Handbook of Experimental Pharmacology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/164_2018_195.

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Zaveri, Nurulain, Faming Jiang, Cris Olsen, Willma Polgar, and Lawrence Toll. "Small-Molecule Agonists and Antagonists of the Opioid Receptor-Like Receptor (ORL1, NOP): Ligand-Based Analysis of Structural Factors Influencing Intrinsic Activity at NOP." In Drug Addiction. Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-76678-2_24.

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Caputi, Francesca Felicia, Patrizia Romualdi, and Sanzio Candeletti. "Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor." In Handbook of Experimental Pharmacology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/164_2018_196.

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Whiteside, Garth T., and Donald J. Kyle. "A Review of the NOP (ORL-1)-Nociceptin/Orphanin FQ System Covering Receptor Structure, Distribution, Role in Analgesia and Reward and Interactions with Other Receptors." In ACS Symposium Series. American Chemical Society, 2013. http://dx.doi.org/10.1021/bk-2013-1131.ch016.

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Witkin, Jeffrey M., Tanya L. Wallace, and William J. Martin. "Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094)." In Handbook of Experimental Pharmacology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/164_2018_186.

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Callard, Ian P., and Gloria V. Callard. "Sex Steroid Receptors and Non-Receptor Binding Proteins." In Hormones and Reproduction in Fishes, Amphibians, and Reptiles. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1869-9_12.

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Conference papers on the topic "Receptor NOP"

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Chesla, Scott E., Bryan T. Marshall, and Cheng Zhu. "Measuring the Probability of Receptor Extraction From the Cell Membrane." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0262.

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Abstract Recently, there has been an increasing interest in measuring the interaction forces between cell adhesion receptors and their ligands [1–3]. These molecules are either anchored on the membrane of a cell or coated on the surface of a substratum. The two surfaces are joined together as a result of the formation of non-covalent bonds between the receptors and ligands. The forces are measured when the two surfaces are separated. In a theoretical paper published nineteen years ago, George Bell estimated the force required to break a receptor-ligand bond and that required to uproot the rece
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Bowry, S. K., and M. Tepel. "NON-REVERSIBLE BINDING OF 5'-p-FLUOROSULFONYLBENZOYL ADENOSINE TO WASHED INTACT PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643506.

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ADP is an important in vivo mediator of platelet aggregation. The identification and estimation of a finite number of receptor sites has been made difficult by the reversible nature of the action of ADP on platelets and because ADP can be degraded by enzymes on the platelet surface. Analogues of ADP have therefore been commonly used to study the ADP receptor. We investigated the validity of using 5'-p-fluorosulfonylbenzoyl adenosine (FSBA), an affinity analogue of ADP that inhibits ADP-induced aggregation, for studying the ADP receptor on intact washed platelets. Binding of labelled FSBA, like
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Hawiger, J. "PLATELET RECEPTOR RECOGNITION DOMAINS AND THEIR SYNTHETIC PEPTIDE ANALOGS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643726.

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Adhesive molecules and their receptorsplay an essential role in hemostasis and thrombosis. Platelet thrombi are formed through the interaction of cell adhesion molecules (CAMs) with intercellular adhesion molecules (IAMs)and substrate adhesion molecules (SAMs). Platelet CAMs encompass membrane glycoproteins lb, lib, Ilia,and possibly la and IV, which constitutemembrane receptors for IAMs(e.g., fibrinogen) and for SAMs encompassingvon Willebrand Factor (vWF), fibronectin, vitronectin, collagen, and thrcmbospondin. Receptorfunction of platelet CAMs can be specific,i.e., only one adhesive protein
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Nuzzo, G. "Fractional diffusion of membrane receptors in endocytosis pathway." In AIMETA 2022. Materials Research Forum LLC, 2023. http://dx.doi.org/10.21741/9781644902431-50.

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Abstract. In this paper the diffusion model representing the motion of membrane receptors with respect to virus endocytosis is considered in the context of applied mechanics. The unexpected behaviour of the receptor density that moves from higher concentrations in the unbound phase to lower concentration at the right of the virus surface is accounted for introducing a mechanical drift term in the governing equation so that the difference of concentrations, higher in the bounded phase and lower in the unbounded phase is accounted for in the receptor motion. Additionally, a non-gaussian model of
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Bernard, Gary D. "Butterfly color vision: spectral properties of photoreceptors and wing patterns." In OSA Annual Meeting. Optica Publishing Group, 1986. http://dx.doi.org/10.1364/oam.1986.tuh1.

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Studies of butterfly mating behavior have shown that colored wing patterns provide important signals for detection and recognition of a proper mate. Butterfly retinas contain three or four spectral types of photoreceptor, but the spectral locations of peak sensitivity for the types differ greatly among the species. Relative abundance also varies greatly. The goal of this study is to relate the spectral properties of receptor systems to those of wing patterns. Spectral sensitivity functions of each spectral type of receptor are measured optophysiologically. Reflectance spectra of wing patches a
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Zehender, H., E. C. Witte, K. Stegemeier, and A. Patscheke. "IRREVERSIBLE BLOCKADE OF THE THROMBOXANE A2/PROSTAGLANDIN H2 RECEPTOR OF HUMAN PLATELETS BY AZIDO-BSP." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643755.

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Azido-BSP (4-[2-(4-azido-benzenesulphonylamino)-ethyl]phen-oxyacetic acid) is a photolabile derivative of the competitive thromboxane A2 /prostaglandin H2 (TXA2/PGH2) receptor antagonist sulotroban (=BM 13.177). If protected from short wave light, azido-BSP reversibly inhibited the platelet shape change induced by the PGH2 analogue U 46619 but notthe shape change induced by ADP or PAF. Schild analysis revealed an apparent KD=0.2 μM with washed platelets. The irreversible inhibition requiredirradiation of the platelet suspensionwith UVlight (254 nm) for 5 minutes in the presenceof azido-BSP. Af
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Bakhit, C., D. Lewis, R. Billings, and B. Malfroy. "CELLULAR CATABOLISM OF RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL HIGH AFFINITY UPTAKE SYSTEM ON RAT HEPATOCYTES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644400.

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The uptake, internalization and intracellular degradation of 125I-labeled rt-PA (125I-rt-PA) by isolated rat hepatocytes was investigated. Incubation at 37°C resulted in internalization of 125I-rt-PA, followed by the appearance of labeled trichloroacetic acid-soluble (TCA) material in the inclubation media due to degradation of rt-PA. Degradation of rt-PA was inhibited by the presence of NH4Cl (10mM) or chloroquine (ImM) (lysosoma tropic agents) in the incubation media. This suggests that rt-PA degradation occurs intracellularly, perhaps within the lysosomes. 125I-rt-PA was taken up by rat hep
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Asaji, T., E. Murakami, N. Takekoshi, S. Matsui, and T. Imaoka. "EFFECT OF ATRIAL NATRIURETIC POLYPEPTIDES ON PLATELET FUNCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644872.

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Atrial natriuretic polypeptides (ANP) have been shown to possess a potent diuretic and natriuretic activity, and medicated to patients with heart insufficiency as a drug to be mediated by cGMPaccumulation in glomeruli. A existence of receptors for ANP have recently beenreported in human platelet. But, whether ANP has a direct effect on platelet function remains to be known.Single stimulation of ANP in any concentration did not induce aggregation in neither platelet rich plasma, nor washed platelets. Also no effect of pretreatment with ANP was observed against aggregation triggered by known med
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De Chaffoy de Courcells, D., and F. De Clerck. "THE EFFECT OF A COMBINED TXA2SYNTHETASE AND TXA2/PROSTAGLANDIN ENDOPEROXIDE RECEPTOR BLOCKER(R 68 070)ON THE ACTIVATION OF EXCITATORY RECEPTOR-COUPLEDPHOSPHOLIPASE C IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643758.

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Prostaglandin endoperoxides (PGEND) and thromboxane A2 (TxA2)contribute to the activation of platelets, involving inositol-containing phospholipids as a signal transducing system. A primary step in this signal transduction consists of the activation of phospholipase C, which then yields diacylglycerol and inositol phosphates;diacylglycerol is subsequently phosphorylated to phosphatidic acid (PA). In platelets prelabelled with [32P] orthophosphate,receptor activation is quantitatively reflected by an increased formation of [32P]-PA.Using this assay, the relativeimportance of endogenously genera
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Pfliegler, G., J. Arnout, J. Kienast, K. Wittevrongel, and J. Vermylen. "INSULIN RECEPTORS ARE NOT COUPLED TO THE PHOSPHOINOSITIDE OR ADENYLCYCLASE MESSENGER SYSTEMS IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644523.

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Insulin receptors have been found not only on its “target Cells” but also on several other cell-types, including human platelets. From studies on adipocytes and liver cells it seems that they are coupled both to the adenylate cyclase-cyclic AMP and the polyphosphoinositide messenger systems. Circulating blood cells might faithfully reflect the insulin receptor state of target organ tissues. Impaired platelet function has an important role in the pathogenesis of vascular and thrombotic complications in diabetes mellitus, and insulin seems to act directly on platelets. A reduction in the number
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Reports on the topic "Receptor NOP"

1

Ko, Mei-Chuan. Pharmacological Studies of NOP Receptor Agonists as Novel Analgesics. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada486029.

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Ko, Mei-Chuan. Pharmacological Studies of NOP Receptor Agonists as Novel Analgesics. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada525900.

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Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mut
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Altstein, Miriam, and Ronald J. Nachman. Rational Design of Insect Control Agent Prototypes Based on Pyrokinin/PBAN Neuropeptide Antagonists. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7593398.bard.

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The general objective of this study was to develop rationally designed mimetic antagonists (and agonists) of the PK/PBAN Np class with enhanced bio-stability and bioavailability as prototypes for effective and environmentally friendly pest insect management agents. The PK/PBAN family is a multifunctional group of Nps that mediates key functions in insects (sex pheromone biosynthesis, cuticular melanization, myotropic activity, diapause and pupal development) and is, therefore, of high scientific and applied interest. The objectives of the current study were: (i) to identify an antagonist bioph
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Rafaeli, Ada, Russell Jurenka, and Chris Sander. Molecular characterisation of PBAN-receptors: a basis for the development and screening of antagonists against Pheromone biosynthesis in moth pest species. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7695862.bard.

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The original objectives of the approved proposal included: (a) The determination of species- and tissue-specificity of the PBAN-R; (b) the elucidation of the role of juvenile hormone in gene regulation of the PBAN-R; (c) the identificationof the ligand binding domains in the PBAN-R and (d) the development of efficient screening assays in order to screen potential antagonists that will block the PBAN-R. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are
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Gurevitz, Michael, William A. Catterall, and Dalia Gordon. face of interaction of anti-insect selective toxins with receptor site-3 on voltage-gated sodium channels as a platform for design of novel selective insecticides. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699857.bard.

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Voltage-gated sodium channels (Navs) play a pivotal role in excitability and are a prime target of insecticides like pyrethroids. Yet, these insecticides are non-specific due to conservation of Navs in animals, raising risks to the environment and humans. Moreover, insecticide overuse leads to resistance buildup among insect pests, which increases misuse and risks. This sad reality demands novel, more selective, insect killers whose alternative use would avoid or reduce this pressure. As highly selective insect toxins exist in venomous animals, why not exploit this gift of nature and harness t
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Stearns, Carrie. Role of the Non-Receptor Tyrosine Kinase ACK2 in EGF Receptor Degradation. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada427754.

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Stearns, Carrie. Role of the Non-Receptor Tyrosine Kinase ACK2 in EGF Receptor Degradation. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada435047.

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Funkenstein, Bruria, and Cunming Duan. GH-IGF Axis in Sparus aurata: Possible Applications to Genetic Selection. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7580665.bard.

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Many factors affect growth rate in fish: environmental, nutritional, genetics and endogenous (physiological) factors. Endogenous control of growth is very complex and many hormone systems are involved. Nevertheless, it is well accepted that growth hormone (GH) plays a major role in stimulating somatic growth. Although it is now clear that most, if not all, components of the GH-IGF axis exist in fish, we are still far from understanding how fish grow. In our project we used as the experimental system a marine fish, the gilthead sea bream (Sparus aurata), which inhabits lagoons along the Mediter
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Sessa, Guido, and Gregory Martin. role of FLS3 and BSK830 in pattern-triggered immunity in tomato. United States Department of Agriculture, 2016. http://dx.doi.org/10.32747/2016.7604270.bard.

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Pattern-recognition receptors (PRRs) located on the plant cell surface initiate immune responses by perceiving conserved pathogen molecules known as pathogen-associated molecular patterns (PAMPs). PRRs typically function in multiprotein complexes that include transmembrane and cytoplasmickinases and contribute to the initiation and signaling of pattern-triggered immunity (PTI). An important challenge is to identify molecular components of PRR complexes and downstream signaling pathways, and to understand the molecular mechanisms that mediate their function. In research activities supported by
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