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Dissertations / Theses on the topic 'Receptor NOP'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

AZEVEDO, NETO Joaquim Gonalves. "NOP and mu opioid receptors: novel ligands and therapeutic opportunities." Doctoral thesis, Università degli studi di Ferrara, 2021. http://hdl.handle.net/11392/2487852.

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The aim of the study was to characterize new ligands and study new therapeutic opportunities for the N / OFQ - NOP receptor and the classic opioid receptors. The NOP and opioid receptors are 7TM receptors coupled with inhibitory G proteins. These receptors control various biological functions, such as the transmission of pain and the modulation of emotional states. The pharmacological concept of functional selectivity (aka bias agonism) could be useful for amplifying beneficial actions and / or counteracting side effects. To study the potential of biased agonism, new molecules with a large pol

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2

MOLINARI, Stefano. "Nociceptin/orphanin FQ – NOP receptor system: novel genetic and pharmacological tools." Doctoral thesis, Università degli studi di Ferrara, 2012. http://hdl.handle.net/11392/2389416.

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The neuropeptide nociceptin/orphanin FQ (N/OFQ) selectively binds and activates the N/OFQ peptide (NOP) receptor. In cells expressing the NOP receptor N/OFQ inhibits cAMP accumulation and Ca2+ conductance and stimulates K+ currents. Via these mechanisms N/OFQ regulates several biological functions in the central nervous system (pain, locomotion, memory, emotional responses, food intake), as well as in the periphery (airways, cardiovascular, genitourinary and gastrointestinal systems). Several research tools including knockout mice and NOP selective agonists and antagonists have been devel

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FISCHETTI, Carmela. "NOCICEPTIN/ORPHANIN FQ RECEPTOR LIGANDS: PHARMACOLOGICAL STUDIES." Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2389221.

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The neuropeptide nociceptin/orphanin FQ (N/OFQ) selectively binds and activates the N/OFQ peptide (NOP) receptor. At cellular level N/OFQ inhibits cAMP accumulation and Ca2+ conductance and stimulates K+ currents. N/OFQ regulates several biological functions both at central (pain, locomotion, memory, emotional responses, food intake) and peripheral (airways, cardiovascular, genitourinary and gastrointestinal systems) sites. Potent and selective NOP ligands are now required for investigating the roles played by NOP receptors in pathophysiological studies and for firmly defining the therap

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CERLESI, Maria Camilla. "Pharmacological characterization of novel ligands acting as NOP/opioid receptor agonists." Doctoral thesis, Università degli studi di Ferrara, 2016. http://hdl.handle.net/11392/2403470.

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La famiglia dei recettori oppioidi comprende i classici recettori oppioidi, mu (MOP), delta (DOP) e kappa (KOP) ed un quarto membro, chiamato recettore NOP, identificato come il recettore del peptide endogeno nocicettina/orfanina FQ (N/OFQ). Proprio per la sua distinta farmacologia, il recettore NOP è indicato come un ramo non oppioide della famiglia dei recettori oppioidi. Nonostante l’uso di farmaci oppiacei come morfina o fentanil, selettivi principalmente per il recettore MOP, sia associato a diversi effetti collaterali, tra cui la depressione respiratoria, stipsi, la tolleranza e la respo

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MALFACINI, Davide. "Novel ligands and assays for nociceptin/orphanin FQ and classical opioid receptors." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2388991.

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The aim of the present study was twofold: pharmacologically characterize novel ligands and set-up and validate novel in vitro assays for nociceptin/orphanin FQ (N/OFQ) peptide (NOP) and classical opioid receptors. NOP and opioid receptors are 7TM receptors coupled with inhibitory G proteins; receptor activation leads to the inhibition of cAMP formation and calcium currents, and opening of potassium channels. Via these cellular inhibitory mechanisms, the N/OFQ – NOP receptor and classical opioid systems regulate a variety of biological functions both in the central nervous system and in the per

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Fernandes, Diego Alexandre da Cunha. "Efeito de ligantes do receptor NOP no modelo animal de mania induzido por metilfenidato." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br/handle/123456789/19497.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2015-12-14T22:12:12Z No. of bitstreams: 1 DiegoAlexandreDaCunhaFernandes_DISSERT.pdf: 2456718 bytes, checksum: 24278166db119fb91c70503ebcefc8dd (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2015-12-18T21:13:23Z (GMT) No. of bitstreams: 1 DiegoAlexandreDaCunhaFernandes_DISSERT.pdf: 2456718 bytes, checksum: 24278166db119fb91c70503ebcefc8dd (MD5)<br>Made available in DSpace on 2015-12-18T21:13:23Z (GMT). No. of bitstreams: 1 DiegoAlexandreDaCunhaFernandes_DISSERT.pdf: 2456718 byte

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ARCURI, Ludovico. "N/OFQ and the NOP receptor: a target with broad potential in Parkinson’s Disease." Doctoral thesis, Università degli studi di Ferrara, 2016. http://hdl.handle.net/11392/2403505.

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Il neuropeptide nocicettina/orfanina FQ (N / OFQ) ed il suo recettore (NOP) svolgono un ruolo patogenetico nella malattia di Parkinson (PD). Questo lavoro di tesi ha cercato di affrontare due questioni diverse e irrisolte legate al ruolo del sistema N/OFQ-NOP nel PD. Il primo, e forse più rilevante, è se N/OFQ endogena contribuisca alla morte dei neuroni dopaminergici della substantia nigra compacta, il segno distintivo del PD. Utilizzando modelli genetici ed etologici di PD, siamo stati in grado di dimostrare che la rimozione genetica ed il blocco farmacologico del recettore NOP hanno un impa

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FERRARI, Federica. "Pharmacological profile of nociceptin/orphanin FQ receptor – characterization of novel peptide and non peptide ligands." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2478798.

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Il peptide nocicettina/orfanina FQ (N/OFQ) è il ligando endogeno del recettore NOP; questo sistema peptidergico controlla diverse funzioni biologiche sia nel sistema nervoso centrale che in periferia. Lo scopo del presente studio è stata la caratterizzazione farmacologica di nuovi ligandi peptidici e non-peptidici per il recettore NOP. Una serie di composti N/OFQ dimerici e l’antagonista PWT2-UFP-101 sono stati progettati e sintetizzati nella nostra Università, mentre i ligandi non-peptidici investigati provengono da case farmaceutiche. Tutti i composti sono stati valutati in vitro in diversi

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Philip, Ashok E. "Design, synthesis, molecular modeling, and biological evaluation of novel NOP (nociceptin/orphanin FQ peptide) receptor ligands /." Full text available from ProQuest UM Digital Dissertations, 2006. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1394651401&SrchMode=1&sid=2&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1216913414&clientId=22256.

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Gavioli, Elaine Cristina. "Participação do sistema nociceptina/orfanina fq-receptor nop na modulação da ansiedade e da depressão experimental." Florianópolis, SC, 2003. http://repositorio.ufsc.br/xmlui/handle/123456789/85920.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia<br>Made available in DSpace on 2012-10-21T01:17:06Z (GMT). No. of bitstreams: 1 199341.pdf: 976921 bytes, checksum: 9acbff52ed3709e69189fc23ed6ec0ff (MD5)<br>O presente trabalho estudou o papel da nociceptina (N/OFQ) e da nocistatina (NST) na modulação da ansiedade e da depressão experimental. Nossos dados mostraram que camundongos tratados com N/OFQ apresentaram um perfil do tipo ansiolítico no teste do labirinto em cruz elevado (LCE), enquanto que a NST induziu

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Ruggieri, Valentina. "Coinvolgimento del sistema peptidergico centrale nocicettina/orfanina FQ, N/OFQ al recettore NOP nella modulazione del dolore e nei disturbi dell'umore: ansia e depressione." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426856.

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Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are widely distributed in the central nervous system (CNS), where they modulate several functions such as pain, anxiety, stress, learning, memory, food intake and drug addiction. On this basis, the purpose of the present research was to investigate, in the rat, the role of NOP ligands in: a) modulation on nociception in paracetamol-induced analgesia; b) anxiety-related behaviours after development of tolerance to hypolocomotor effects and c) exposure to chronic stressful conditions which cause depression. As regards point a), we have demo

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Souza, Lisiane de Santana. "Padroniza??o de testes para avalia??o do estado de mania e potencial anti-man?aco de um agonista do receptor NOP." Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/19849.

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Medeiros, Iris Ucella de. "Sinaliza??o end?gena do sistema Nociceptina/Orfanina FQ - receptor NOP: envolvimento na modula??o da depress?o experimental induzida por lipopolissacar?deo." Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20585.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-05-31T20:39:36Z No. of bitstreams: 1 IrisUcellaDeMedeiros_TESE.pdf: 1627038 bytes, checksum: abacbae1a6fa2f0ce88c897b540dedc4 (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-06-03T00:28:56Z (GMT) No. of bitstreams: 1 IrisUcellaDeMedeiros_TESE.pdf: 1627038 bytes, checksum: abacbae1a6fa2f0ce88c897b540dedc4 (MD5)<br>Made available in DSpace on 2016-06-03T00:28:56Z (GMT). No. of bitstreams: 1 IrisUcellaDeMedeiros_TESE.pdf: 1627038 bytes, checksum: abacbae1a6fa2f0ce88c897b54

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Fernandes, Laila da Silva Asth. "Efeitos in vivo e in vitro de agonistas parciais do receptor NOP: implica??es para o tratamento da ansiedade, depress?o e mania." Universidade Federal do Rio Grande do Norte, 2016. http://repositorio.ufrn.br/handle/123456789/21010.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-07-21T16:51:55Z No. of bitstreams: 1 LailaDaSilvaAsthFernandes_TESE.pdf: 3019441 bytes, checksum: b9d834e9c1a7ede2d053a98c33bde78e (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-07-21T21:49:55Z (GMT) No. of bitstreams: 1 LailaDaSilvaAsthFernandes_TESE.pdf: 3019441 bytes, checksum: b9d834e9c1a7ede2d053a98c33bde78e (MD5)<br>Made available in DSpace on 2016-07-21T21:49:55Z (GMT). No. of bitstreams: 1 LailaDaSilvaAsthFernandes_TESE.pdf: 3019441 bytes, checksum: b9d834e9c1a

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Azevedo, Neto Joaquim Gon?alves de. "Efeito do agonista do receptor da nociceptina/orfanina FQ, Ro65-6570, no comportamento do tipo ansioso de camundongos desamparados." PROGRAMA DE P?S-GRADUA??O EM PSICOBIOLOGIA, 2017. https://repositorio.ufrn.br/jspui/handle/123456789/24443.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-12-04T20:41:48Z No. of bitstreams: 1 JoaquimGoncalvesDeAzevedoNeto_DISSERT.pdf: 1209476 bytes, checksum: b176b29c8fe26fd7b3e020bb5279ef38 (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-12-07T19:42:32Z (GMT) No. of bitstreams: 1 JoaquimGoncalvesDeAzevedoNeto_DISSERT.pdf: 1209476 bytes, checksum: b176b29c8fe26fd7b3e020bb5279ef38 (MD5)<br>Made available in DSpace on 2017-12-07T19:42:32Z (GMT). No. of bitstreams: 1 JoaquimGoncalvesDeAzevedoNeto_DISSERT.pdf: 1209476 bytes,

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VIARO, Riccardo. "Nociceptin/orphanin FQ and motor activity: behavioural, biochemical and electrophysiological studies in models of Parkinson’s disease." Doctoral thesis, Università degli studi di Ferrara, 2010. http://hdl.handle.net/11392/2389326.

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Nociceptin/orphanin FQ (N/OFQ) is an opioid-like neuropeptide which activates the NOP receptor. N/OFQ exerts an inhibitory control on locomotion through inhibition of dopamine (DA) neurons located in the substantia nigra (SN), which degenerate in Parkinson’s disease (PD). In the present study, we demonstrated that NOP receptor antagonists facilitated and inhibited motor behavior in 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine (MPTP)-treated mice and nonhuman primates depending on dose. In naïve mice, we found that dual response to NOP receptor antagonists was DAdependent and mediated b

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Silva, Epifanio Fernandes da. "Efeito de ligantes do receptor da nociceptina/orfanina FQ no comportamento agressivo de camundongos machos." PROGRAMA DE P?S-GRADUA??O EM BIOLOGIA ESTRUTURAL E FUNCIONAL, 2017. https://repositorio.ufrn.br/jspui/handle/123456789/23483.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-06-02T23:17:43Z No. of bitstreams: 1 EpifanioFernandesDaSilva_DISSERT.pdf: 1808656 bytes, checksum: a66e4e7210681ca2462da4ceef086da5 (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-06-12T21:13:37Z (GMT) No. of bitstreams: 1 EpifanioFernandesDaSilva_DISSERT.pdf: 1808656 bytes, checksum: a66e4e7210681ca2462da4ceef086da5 (MD5)<br>Made available in DSpace on 2017-06-12T21:13:37Z (GMT). No. of bitstreams: 1 EpifanioFernandesDaSilva_DISSERT.pdf: 1808656 bytes, checksum: a66e4

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Ravi, Janani. "CROSSTALK BETWEEN CANNABINOID RECEPTORS AND EPIDERMAL GROWTH FACTOR RECEPTOR IN NON-SMALL CELL LUNG CANCER." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1426697196.

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Im, Jin Seon. "Molecular characterization of T cell receptors and non-MHC restricted T cell receptor binding peptides." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284969.

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T cells recognize antigenic peptides presented by MHC molecules on antigen presenting cells (APC) through T cell receptors (TCRs). Since TCRs are very similar to antibodies in structure and genetics, TCRs might have the potential to bind free antigens as antibodies do. Here, peptides which bound TCRs irrespective of MHC molecules have been identified by screening "one-bead one-peptide" combinatorial libraries. Peptides: VRENAR, RTGNYV, GKMHFK, KDAVKR and RKPQAI bound recombinant Jurkat single chain T cell receptors (scTcrs). GKMHFK, KDAVKR and RKPQAI were also specific for natural TCRs on the

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Ferreira, David Wilson. "Mecanismos nociceptivos desencadeados pela ativação espinal dos receptores NOD2 (CARD15) na gênese da dor crônica." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-28052018-152655/.

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Entre os PRRs (receptores de reconhecimento padrão), NOD-like receptors (NLRs), tal como NOD2, são responsáveis pela detecção intracelular de muramil dipeptídeo (MDP); padrão molecular associado a patógeno (PAMP), encontrado no peptidoglicano (PGN) de praticamente todas bactérias GRAM positiva e negativa. Após o reconhecimento e estimulação por MDP, NOD2 recruta diretamente a serina-treonina quinase RIPK2, uma proteína adaptadora importante na ativação de NF?B mediada por NOD2. A expressão de NOD2 foi descrita em macrófagos e em outras células. Além disso, trabalhos anteriores indicaram que PR

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Berlanga, Bustos Alba. "Deregulation of fatty acid metabolism and cannabinoid receptors in liver of morbidly obese women with non-alcoholic fatty liver disease." Doctoral thesis, Universitat Rovira i Virgili, 2015. http://hdl.handle.net/10803/325135.

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La malaltia del fetge gras no alcohòlic (MFGNA) inclou un espectre histològic que va des de la esteatosi simple (SS) a l'esteatohepatitis no alcohòlica (EHNA), sent aquesta última freqüentment progressiva. Donat que l'acumulació hepàtica de lípids sembla ser un mecanisme crucial en la patogènesi de la MFGNA, una millor comprensió dels mecanismes subjacents que condueixen a l'acumulació inicial de lipíds hepàtics podria ser de gran interès per controlar la progressió de la malaltia. El sistema endocannabinoide (SE), mitjançant principalment els receptors cannabinoides CB1 i CB2, sembla ser que

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Pittolo, Silvia. "Development of light-modulated allosteric ligands for remote, non-invasive control of neuronal receptors." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/482011.

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In the brain events happen in the scale of milliseconds, and the fine processes of neurons and neuroglia are highly compartmentalized at a microscopic level. These exclusive features of the brain define extremely precise temporal and spatial patterns of cellular activity, which are of fundamental importance for its proper functioning, because they allow the fast processing, sorting, integration, and flow of information with high reproducibility and precision. To gain deeper understanding of how these patterns are organized in time and space, we need new tools that overcome the spatiotemporal l

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Haga, Christopher L. "Analysis of the role of FCRL5 and FIGLERs in B cell development, signaling and malignancy." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/haga.pdf.

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Chen, Zhixiong. "Brainstem Mechanisms Underlying Ingestion and Rejection." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1041523002.

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Powell, Krista M. "The Role of KRAS in Mechanosensing in Non-Small Cell Lung Cancer." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5869.

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Lung cancer is the number one cause of cancer related death worldwide, with more than 1.6 million fatalities each year. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all lung cancers, with KRAS being one of the most prevalent oncogenic driver mutations. Therapeutic approaches for KRAS-mutated NSCLC have been extensively explored due to the US National Cancer Institute RAS Initiative, but methods of directly targeting KRAS or downstream effectors, such as MEK, still have poor results. Previous reports have shown that KRAS-mutated NSCLC activate distinct receptor tyrosine kinases (RT

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Sharma, Devinder. "Pregnane X receptor and constitutive androstane receptor activation by non-nucleoside HIV-1 reverse transcriptase inhibitors." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57623.

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Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are important anti-retroviral drugs indicated in combination therapy of human immunodeficiency virus-1 (HIV-1) infection. NNRTI therapy is associated with pharmacokinetic drug interactions, the underlying mechanisms of which are poorly understood. The present study investigated the effects of NNRTIs on the activity of pregnane X receptor (PXR) and constitutive androstane receptor (CAR), key transcriptional factors regulating the expression of various drug-metabolizing enzymes and transporters. The experimental approaches included cell

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Flora, Gagan Deep. "Non-genomic effects of the Pregnane X Receptor (PXR) and Retinoid X Receptor (RXR) in platelets." Thesis, University of Reading, 2018. http://centaur.reading.ac.uk/80709/.

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Kershaw, Stephen. "Investigating the non-genomic actions of the glucocorticoid receptor." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/investigating-the-nongenomic-actions-of-the-glucocorticoid-receptor(6661c46b-8333-4bb3-904e-5f9cbcc9b936).html.

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Glucocorticoids (GCs) are a class of steroid hormone that play essential roles in development, glucose homeostasis, and reducing inflammation. Clinically, GCs are potent anti-inflammatory and immunosuppressive agents used to treat a variety of diseases. However, the therapeutic benefit of GCs is negatively impacted by the induction of severe side effects. In this thesis, I present two studies that have contributed to the understanding of the non-genomic actions of GCs. GCs inhibit cell migration by a non-transcriptional pathway involving HDAC6: A negative side effect of GC therapy is impaired

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Jorgensen, William. "The Discovery of Selective Non-Peptidic Oxytocin Receptor Ligands." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16542.

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This thesis describes the design, synthesis and pharmacological profile of a library of selective oxytocin receptor ligands. Oxytocin and arginine vasopressin are structurally related neuropeptides that have well known neuromodulatory roles in social affiliative behaviour. Deficiencies in either of these signalling pathways are implicated in social dysfunction, a pathophysiology concommitant with psychiatric disorders such as depression and anxiety. Despite over a century of investigation, only one, non-peptidic oxytocin receptor agonist has been identified; WAY-267,464. The ambiguity surround

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Kotitschke, Andrea. "Genomic and Non-Genomic cross talk between the Gonadotropin- releasing hormone receptor and glucocorticoid receptor signalling pathways." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/4283.

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Prates, Talita Pereira. "Papel dos receptores tipo NOD na modulação da reabsorção óssea em modelo de periodontite experimental." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/58/58135/tde-02022015-105829/.

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O biofilme bacteriano é o agente etiológico primário no desenvolvimento da resposta inflamatória observada na doença periodontal. Os receptores do tipo NOD (NLRs) são proteínas citosólicas que reconhecem componentes microbianos presentes no citoplasma liberados por bactérias invasoras. Sabendo que bactérias periodontopatogênicas têm a capacidade de invadir e colonizar diversas células do tecido periodontal, o presente projeto tem o objetivo de estudar a participação dos receptores do tipo NOD (NOD1 e NOD2) no reconhecimento das bactérias Porphyromonas gingivalis, na modulação da resposta imune

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Willins, David L. "The role of excitatory amino acid receptors in the basal forebrain in the locomotor response produced by psychostimulants and the non-competitive NMDA receptor antagonist MK801 /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487779439846962.

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Denham, Eleanor Mary. "Investigating the mechanism of non-catalytic tyrosine-phosphorylated receptor triggering." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:8cbd8043-d02d-4294-ace9-a2e92670aa63.

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Non-catalytic tyrosine-phosphorylated receptors (NTRs) are a large group of leukocyte receptors that bind to surface-associated ligands and include both activating and inhibitory members. They contain, or associate with adaptor molecules which contain, tyrosine residues within conserved cytoplasmic motifs that are phosphorylated and dephosphorylated by extrinsic kinases and phosphatases respectively. The mechanism by which NTR-ligand engagement leads to sustained phosphorylation of receptor tyrosinebased motifs and initiation of downstream signalling (termed "receptor triggering"), is as yet u

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COGNEZ, PIERRE. "Obtention de contantes de binding par regression non lineaire : application aux recepteurs cholinergiques." Rennes 1, 1991. http://www.theses.fr/1991REN1B018.

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Trois types d'experiences de binding ont ete realises sur des synaptosomes d'hyppocampe de rat: 1a) binding direct de l'alphabungarotoxine sur les recepteurs nicotiniques; 1b) binding direct du quinuclidinyl benzilate sur les recepteurs muscariniques; 2a) competition entre l'alphabungarotoxine tritiee et la meme molecule non marquee sur les recepteurs nicotiniques; 2b) competition entre le quinuclidinyl benzilate tritie et la meme molecule non marquee sur les recepteurs muscariniques; 3a) deplacement du quinuclidinyl benzilate tritie par l'acetylcholine non marquee des recepteurs muscariniques

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Orrego-Carmona, David. "The reception of (non)professional subtitling." Doctoral thesis, Universitat Rovira i Virgili, 2015. http://hdl.handle.net/10803/306439.

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Actualment, la subtitulació no professional permet a persones de tot el món accedir a material audiovisual en altres idiomes. Aquesta recerca estudia la recepció de la subtitulació professional i no professional entre estudiants universitaris amb diferents nivells d’anglès. L’estudi inclou els subtítols professionals per a DVD distribuïts a Espanya i dues versions no professionals, una espanyola i una llatinoamericana. Es va fer servir una enquesta inicial per estudiar la població i avaluar el seu nivell d’anglès. En aquesta etapa es van recol•lectar 332 respostes. La segona etapa va combinar

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Said, Najeeb Barrah. "The design and synthesis of non-peptide bradykinin B2 receptor antagonists." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285827.

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Al-Hussary, Nabeel A. J. "Insulin receptor binding in hypertension and non-insulin dependent diabetes mellitus." Thesis, Aston University, 1986. http://publications.aston.ac.uk/14510/.

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Dehus, Oliver. "Receptor polymorphisms and non-classical immune stimuli in bacterial immune recognition." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-61639.

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MacQueen, David A. "Non-competitive NMDA receptor antagonist impairs olfactory memory span in rats." View electronic thesis (PDF), 2009. http://dl.uncw.edu/etd/2009-1/macqueend/davidmacqueen.pdf.

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Katte, Timothy Aaron. "The Design and Synthesis of Small Non-Peptide Oxytocin Receptor Ligands." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23740.

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This thesis describes the design, synthesis and pharmacological evaluation of non-peptide based oxytocin receptor ligands for the treatment of mental disorders. The current work describes the investigation of pharmacophores for the oxytocin receptor based on scaffolds such as diazepines and elaborate carbazole derivatives as head groups. These cores were modified by altering heteroatoms, ring size and shape and adding a pendant cyclic amide. The pendant cyclic amide has been found to be a requisite for observing oxytocin receptor activation and changes to the core were made to synthesise a li

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NILSON, Ashley Nicole. "G protein biased signaling by non-catechol dopamine D1 receptor agonists." Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395210.

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Dopamine is a catecholamine neurotransmitter with essential roles in voluntary movement, working memory, attention, and reward. Dopamine acts through five G protein coupled receptors with the D1 and D5 receptors (D1R) stimulating Galphas/olf activation and increasing neuronal excitability. Deficits in D1R signaling are implicated in Parkinson’s disease motor deficits as well as cognitive deficits in schizophrenia and attention deficit hyperactivity disorder. For more than 40 years, academic and industry scientists have been searching for a drug-like D1R agonist, but this has remained elusive.

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Pulipakkam, Radhakrishnan Uvaraj. "Studies on Zebrafish Thrombocyte Function." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc984278/.

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Thrombocytes are important players in hemostasis. There is still much to be explored regarding the molecular basis of the thrombocyte function. In our previous microarray analysis data, we found IFT122 (an intraflagellar transport protein known to be involved in cilia formation) transcripts in zebrafish thrombocytes. Given recent discoveries of non-ciliary roles for IFTs, we examined the possibility that IFT122 affects thrombocyte function. We studied the role of IFT122 in thrombocyte function. We also found that IFT122 plays a central role in thrombocyte activation initiated by the agonists A

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Olson, Keith Mathew, and Keith Mathew Olson. "Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/626669.

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Most clinical opioids produce analgesia through the Mu Opioid Receptor (MOR) providing the only effective treatment for chronic pain patients. These studies explore three pre-clinical strategies to improve MOR analgesia and minimize side effects: 1) compounds that target G-protein Coupled Receptors (GPCRs) heterodimers, such as heterodimerization between the Delta Opioid Receptor (DOR) and MOR (MDOR); 2) multi-functional compounds that target multiple receptor systems for synergistic effects, such as a MOR agonist and a the serotonin reuptake transporter (SERT) inhibitor; or 3) biased agonists

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Collins, Louise. "A non-viral vector system for efficient gene transfer via membrane integrins." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321961.

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Alhamdan, Nasser. "Genomic vs. Non-genomic Role of the AhR in Human Immunoglobulin Expression." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1500334184946128.

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Timony, Paula Anne. "Functional over expression of mammalian non-NMDA glutamate receptors." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368365.

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Tian, Liantian. "G Protein Coupling and Regulation of Metabotropic Glutamate Receptor 6." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1271657783.

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Benner, Sarah E. "Characterizing the Role Toll Like Receptor 3 (TLR3) Plays in Viral-Mediated Type 1 Diabetes in Female Non-Obese Diabetic (NOD) Mice." Ohio University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1547131981099488.

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Johansson, Tobias. "Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8503.

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<p>The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection. Their effects emerge from rapid interactions with membrane bound receptors, such as the N-methyl-D-aspartate (NMDA) receptor, the gamma-amino-butyric acid receptor and the sigma 1 receptor. The mechanisms of action are separate from classical genomic interactions. </p><p>The aims of this thesis were to identify and characterize the molecular mechanisms underlying the

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Zhang, Yu Ling. "Characterization of HD-PTP phosphatase activity and identification of its substratesbinding partners." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111552.

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Histidine-Domain-Protein-Tyrosine-Phosphatase (HD-PTP) has been classified as a non-transmembrane protein tyrosine phosphatase (PTP), however, its catalytic activity has not been appropriately characterized. In this thesis, the tyrosine phosphatase activity of HD-PTP was characterized. To do so, the HD-PTP protein was successfully purified using the FLAG-TAG purification system and an enzymatic assay was carried out using the DiFMUP fluorogenic substrate. My results suggest that HD-PTP is an inactive PTP that can be reactivated upon the back mutation of a conserved amino acid located in its ca

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