Academic literature on the topic 'Receptors to estrogens'

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Journal articles on the topic "Receptors to estrogens"

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Chmielewska, Małgorzata, Izabela Skibińska, and Małgorzata Kotwicka. "Mitochondria: Target organelles for estrogen action." Postępy Higieny i Medycyny Doświadczalnej 71, no. 1 (2017): 0. http://dx.doi.org/10.5604/01.3001.0010.3828.

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Estrogens belong to a group of sex hormones, which have been shown to act in multidirectional way. Estrogenic effects are mediated by two types of intracellular receptors: estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2). There are two basic mechanisms of estrogen action: 1) classical-genomic, in which the ligand-receptor complex acts as a transcriptional factor and 2) a nongenomic one, which is still not fully understood, but has been seen to lead to distinct biological effects, depending on tissue and ligand type. It is postulated that nongenomic effects may be associated with membr
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Arterburn, Jeffrey B., and Eric R. Prossnitz. "G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications." Annual Review of Pharmacology and Toxicology 63, no. 1 (2023): 295–320. http://dx.doi.org/10.1146/annurev-pharmtox-031122-121944.

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The actions of estrogens and related estrogenic molecules are complex and multifaceted in both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways that produce and respond to estrogens. Multiple receptors promulgate these responses, including the classical estrogen receptors of the nuclear hormone receptor family (estrogen receptors α and β), which function largely as ligand-activated transcription factors, and the 7-transmembrane G protein–coupled estrogen receptor, GPER, which activates a diverse array of signaling pathways. The pharmacology and functional ro
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Kumar, Anita, Antara Banerjee, Dipty Singh, et al. "Estradiol: A Steroid with Multiple Facets." Hormone and Metabolic Research 50, no. 05 (2018): 359–74. http://dx.doi.org/10.1055/s-0044-100920.

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AbstractSeventy-five glorious years have passed since estradiol was discovered by Edward Doisy. From discovery in the ovaries to delineation of diverse physiological effects, research on estrogens has covered a lot of ground. Estrogen receptors that mediate estrogenic effects, have been detected not only in reproductive organs, but also in other body organs. Estrogen receptors function either as conventional transcription factors or as rapid signal transducers. These different modes of action are opted by estrogens to elicit an array of reproductive and non-reproductive functions. It is well e
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Lee, Heehyoung, and Wenlong Bai. "Regulation of Estrogen Receptor Nuclear Export by Ligand-Induced and p38-Mediated Receptor Phosphorylation." Molecular and Cellular Biology 22, no. 16 (2002): 5835–45. http://dx.doi.org/10.1128/mcb.22.16.5835-5845.2002.

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ABSTRACT Estrogen receptors are phosphoproteins which can be activated by ligands, kinase activators, or phosphatase inhibitors. Our previous study showed that p38 mitogen-activated protein kinase was involved in estrogen receptor activation by estrogens and MEKK1. Here, we report estrogen receptor-dependent p38 activation by estrogens in endometrial adenocarcinoma cells and in vitro and in vivo phosphorylation of the estrogen receptor α mediated through p38. The phosphorylation site was identified as threonine-311 (Thr311), located in helix 1 of the hormone-binding domain. The mutation of thr
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Bernasochi, Gabriel B., James R. Bell, Evan R. Simpson, Lea M. D. Delbridge, and Wah Chin Boon. "Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots." Comprehensive Physiology 9, no. 2 (2019): 457–75. https://doi.org/10.1002/j.2040-4603.2019.tb00071.x.

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ABSTRACTAs adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) and inflammatory mediators, which have important implications in numerous obesity‐associated diseases. Adipose tissues are broadly characterized as consisting of white, beige, and brown depot types. The endocrine, metabolic, and inflammatory profiles of adipose are depot dependent and influenced by the estrogenic and androgenic status of the adipose tissue. Estrogen receptors mediate both the genomic and nongenomic actions of estrogens and are expressed in t
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Lee, Richard R., and Karen P. Phillips. "Role of Estrogen Receptors in Male Reproductive Physiology." Revue interdisciplinaire des sciences de la santé - Interdisciplinary Journal of Health Sciences 3, no. 1 (2016): 40–45. http://dx.doi.org/10.18192/riss-ijhs.v3i1.1452.

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Canonical estrogen receptors (ER α/β) have a genomic mechanism of action, functioning as nuclear transcription factors for estrogen-dependent genes. Estrogen receptors are well established within the male reproductive tract with estrogen playing an essential role for male fertility. The recent characterization of novel G-protein coupled estrogen receptor GPR30 (alternatively known as GPER1), depending on non-genomic intracellular signaling pathways to transduce estrogenic signals, requires a re-examination of the roles of estrogen receptors in male reproduction. Further, the affinity of enviro
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Nilsson, Stefan, Sari Mäkelä, Eckardt Treuter, et al. "Mechanisms of Estrogen Action." Physiological Reviews 81, no. 4 (2001): 1535–65. http://dx.doi.org/10.1152/physrev.2001.81.4.1535.

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Our appreciation of the physiological functions of estrogens and the mechanisms through which estrogens bring about these functions has changed during the past decade. Just as transgenic mice were produced in which estrogen receptors had been inactivated and we thought that we were about to understand the role of estrogen receptors in physiology and pathology, it was found that there was not one but two distinct and functional estrogen receptors, now called ERα and ERβ. Transgenic mice in which each of the receptors or both the receptors are inactive have revealed a much broader role for estro
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Molina, Luis, Felipe A. Bustamante, Kanti D. Bhoola, Carlos D. Figueroa, and Pamela Ehrenfeld. "Possible role of phytoestrogens in breast cancer via GPER-1/GPR30 signaling." Clinical Science 132, no. 24 (2018): 2583–98. http://dx.doi.org/10.1042/cs20180885.

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Estrogens generated within endocrine organs and the reproductive system act as ligands for at least three types of estrogen receptors. Estrogen receptors α (ERα) and β (ERβ) belong to the so-called classical family of estrogen receptors, whereas the G protein-coupled receptor GPR30, also known as GPER-1, has been described as a novel estrogen receptor sited in the cell membrane of target cells. Furthermore, these receptors are under stimulation of a family of exogenous estrogens, known as phytoestrogens, which are a diverse group of non-steroidal plant compounds derived from plant food consume
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Wojnarowski, Konrad, Paulina Cholewińska, Dušan Palić, Małgorzata Bednarska, Magdalena Jarosz, and Iga Wiśniewska. "Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes—Review." International Journal of Molecular Sciences 23, no. 5 (2022): 2605. http://dx.doi.org/10.3390/ijms23052605.

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Estrogen receptors (ERs) play a key role in many biochemical and physiological processes, that are involved in maintaining organism homeostasis. At the most basic level, they can be divided into nuclear estrogen receptors and membrane estrogen receptors that imply their effect in two ways: slower genomic, and faster non-genomic. In these ways, estrogens and xenoestrogens can negatively affect animal health and welfare. Most of the available literature focuses on human and mammalian physiology, and clearly, we can observe a need for further research focusing on complex mutual interactions betwe
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De Giorgi, Vincenzo, Alessia Gori, Marta Grazzini, et al. "Estrogens, estrogen receptors and melanoma." Expert Review of Anticancer Therapy 11, no. 5 (2011): 739–47. http://dx.doi.org/10.1586/era.11.42.

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Dissertations / Theses on the topic "Receptors to estrogens"

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Lee, Isaish Chi Kin. "Measuring the binding kinetics of estrogen receptor alpha and dietary estrogens." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/28.

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Anti-estrogen drugs such as Tamoxifen and Raloxifene are widely prescribed for breast cancer patients. While they are effective, they also have serious side effects. Alternative drugs are therefore being developed. In the drug discovery process, the in vitro binding of estrogen receptors and lead compounds were studied. The binding strength was conventionally quantified in terms of equilibrium dissociation constants (K0 ). However, the binding kinetic rates and especially off-rates (k0 ff) were recently shown to be better indicators of drug potency. In this thesis, we identified a few dietary
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Wade, Christian Bernard. "Mechanisms of estrogen rapid signaling /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/6272.

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Lambert, K. Chad. "The effects of estrogen signaling in innate and adaptive immune cells /." Free to MU Campus, others may purchase, 2005. http://wwwlib.umi.com/cr/mo/fullcit?p3189934.

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Nilsson, Ola. "The role of estrogen in growth plate chondrogenesis /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-410-0/.

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Stavréus-Evers, Anneli. "Implantation : morphological and biochemical characterization of the receptive human endometrium /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-313-9.

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Harrell, Joshua C. "Dissecting roles of estrogen receptors in breast cancer lymphatic metastasis /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Reproductive Sciences) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 125-140). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
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Foryst-Ludwig, Anna [Verfasser]. "Obesity-related cardiovascular and metabolic diseases : the role of estrogens, estrogen receptors and PPARgamma / Anna Foryst-Ludwig." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1052530788/34.

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Trauernicht, Amy Michelle. "The role of the deleted in breast cancer 1 gene product, DBC-1, in estrogen-independent breast cancer cell survival : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1407489201&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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Linford, Nancy J. "Effects of estrogenic compounds on neuronal apoptotic pathways /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/6289.

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Philips, Brian John. "Protein interactions with the catechol estrogens 4-hydroxyestrone and 4-hydroxyestradiol in mouse tissue lysate : binding and metabolism studies /." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3036851.

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Books on the topic "Receptors to estrogens"

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Angerer, Erwin von. The estrogen receptor as a target for rational drug design. Springer, 1995.

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Angerer, Erwin von. The estrogen receptor as a target for rational drug design. Springer, 1995.

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Nobel Symposium on "Estrogens and Women's Health: Benefit or Threat" (113 1999 Karlskoga, Sweden). Proceedings of the Nobel Symposium (No. 113) on "Estrogens and Women's Health: Benefit or Threat": Karlskoga, Sweden, 29 June-1 July 1999. Edited by Gustafsson Jan-Åke and Carlstedt-Duke J. 1953-. Pergamon Press, 2000.

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Eyster, Kathleen M., ed. Estrogen Receptors. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1920-9.

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Eyster, Kathleen M., ed. Estrogen Receptors. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3127-9.

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Manni, Andrea, and Michael F. Verderame, eds. Selective Estrogen Receptor Modulators. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-157-2.

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Zhang, Xiaoting, ed. Estrogen Receptor and Breast Cancer. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-99350-8.

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Andrea, Manni, and Verderame Michael 1957-, eds. Selective estrogen receptor modulators: Research and clinical applications. Humana Press, 2002.

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Pertschuk, Louis P. Immunocytochemistry for steroid receptors. CRC Press, 1990.

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Power, Krista Anne. Selective estrogen receptor modulators in breast cancer. National Library of Canada, 2002.

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Book chapters on the topic "Receptors to estrogens"

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Yen, Paul M. "Dominant Negative Activity by Estrogen and Progesterone Receptors." In Estrogens, Progestins, and Their Antagonists. Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-2004-6_6.

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Behbakht, Kian, and Jeff Boyd. "Estrogen and Progesterone Receptors in Human Endometrial Cancer." In Estrogens, Progestins, and Their Antagonists. Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-2004-6_7.

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Sobek, L., and V. K. Patchev. "Phylogeny of Estrogen Synthesis, Extragenital Distribution of Estrogen Receptors and Their Developmental Role." In Estrogens and Antiestrogens I. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-58616-3_13.

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Wagner, Brandee L., and Donald P. McDonnell. "Saccharomyces cerevisiae As a Model System to Study Steroid Hormone Receptors." In Estrogens, Progestins, and Their Antagonists. Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-2004-6_2.

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Dauvois, Sophie, and Malcolm G. Parker. "Nucleocytoplasmic Shuttling of Estrogen Receptors is Blocked by “Pure Anti-Estrogens”." In Hormonal Carcinogenesis II. Springer New York, 1996. http://dx.doi.org/10.1007/978-1-4612-2332-0_8.

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Edwards, Dean P., and Paul Prendergast. "Facilitated Binding of Steroid Hormone Receptors to Target DNA by the Chromatin High-Mobility Group Protein-1: Protein Manipulation of DNA Structure." In Estrogens, Progestins, and Their Antagonists. Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-2004-6_8.

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Auricchio, F., A. Migliaccio, G. Castoria, et al. "Mechanism of Action of Estrogens: Phosphorylation of Estradiol Receptor on Tyrosine." In Activation of Hormone and Growth Factor Receptors. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-1936-5_21.

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Oosterkamp, H. M., and R. Bernards. "Androgen Receptor and Estrogen Receptors." In Cancer Drug Discovery and Development. Humana Press, 2002. https://doi.org/10.1007/978-1-59259-153-4_16.

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Müller, Judith M., and Roland Schüle. "Sex Steroid Receptors: Androgen Receptor, Estrogen Receptors, Progesterone Receptor." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_163.

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Müller, Judith M., and Roland Schüle. "Sex Steroid Receptors: Androgen Receptor, Estrogen Receptors, Progesterone Receptor." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-21573-6_163-1.

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Conference papers on the topic "Receptors to estrogens"

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Shestakova, E., A. Scherbakov, O. Ryabinina, A. Grishanina, K. Galeeva та T. Bogush. "PO-147 Hypoxia, estrogens and phytoestrogens influence BRCA1 and oestrogen receptors α expression in MCF-7 breast cancer cell line". У Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.669.

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Gurskaya, N. A., and K. V. Kobets. "THE RELATIONSHIP OF POLYMORPHIC VARIANTS OF ESTROGEN RECEPTOR GENES WITH THE DEVELOPMENT OF OSTEOPOROSIS IN THE BELARUSIAN POPULATION." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-245-248.

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A violation of the hormonal balance is considered one of the factors affecting the development of osteoporosis (OP). The study of the molecular and genetic aspects of this fact will allow us to select a more effective course of OP therapy in the future. Sex hormones, as activators of the expression of a number of genes that regulate bone metabolism, act indirectly through specific receptors. We considered polymorphic variants of the estrogen receptor genes ESR1 and ESR2, encoding the a and в subunits of the estrogen receptor, respectively. Among the studied polymorphic variants of ESR1 (rs9340
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Lichtenfels, Martina, Matheus Dalmolin, Julia Caroline Marcolin, Camila Alves da Silva, and Caroline Brunetto de Farias. "Gastrin-releasing peptide receptor as a promising prognostic biomarker in breast cancer." In Brazilian Breast Cancer Symposium 2024. Mastology, 2024. http://dx.doi.org/10.29289/259453942024v34s1028.

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Objective: Previous studies indicated a positive correlation between gastrin-releasing peptide receptor (GRPR) and estrogen receptor (ER) levels, suggesting a potential association between these receptors and tumor progression. This study aimed to verify the expression and prognostic implications of GRP and GRPR in breast cancer by analyzing multiple cancer-related databases. Methodology: The expression and prognosis of GRP and GRPR in breast cancer were assessed using different databases, including ONCOBD, Gent2, and Gene Expression Profiling Interactive Analysis (GEPIA). Results: Bioinformat
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Maia, Fernanda Pimentel Arraes, Maria Clara Tomaz Feijão, Emanuel Cintra Austregésilo Bezerra, Ana Carolina Filgueiras Teles, and Luiz Gonzaga Porto Pinheiro. "MALE BREAST CANCER AFTER LIVER TRANSPLANTATION: A CASE REPORT." In XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1053.

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Male breast cancer (MBC) is an uncommon disease representing only 1% of the total cases. This low incident rate could be due to the low amount of breast tissue and the hormonal differences between men and women. The Surveillance, Epidemiology and End Result (SEER) program reported that the incidence rate of breast cancer was 1.1 per 100,000 men in the mid-1970s and raised to 1.44 per 100,000 men by 2010. There are a lot of characteristics that are common to male and female breast carcinomas, especially given the fact that a lot of the factors that influence malignant changes are similar, but t
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Basu, Gargi D., Ariane Kemkes, Rebecca A. Feldman, et al. "Abstract 3152: Distribution of hormone receptors (estrogen receptor, progesterone receptor and androgen receptor) in epithelial malignancies." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3152.

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Starkey, Nicholas J. E., Lu Yuan, Yufei Li, and Dennis B. Lubahn. "Abstract 2104: Mechanisms for the inhibition of estrogen receptors by estrogen related receptor beta and oxysterols." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2104.

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Thornton, Gail M., Soraya J. Bailey, Xinxin Shao, Douglas Morck, David A. Hart, and Yamini Achari. "Influence of Early Ovariohysterectomy on the Mechanical Properties of Rabbit Medial Collateral Ligament." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176260.

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Female athletes have significantly higher incidence of anterior cruciate ligament (ACL) injuries than males participating in similar sports [1]. To date, no clear explanation has emerged for this disparity. However, hormonal differences may provide an explanation because some ACL injuries have been linked to physiologic fluctuations in estrogen levels over the menstrual cycle [2]. Receptors for estrogen have been identified in rabbit and human ACLs and medial collateral ligaments (MCLs) [3]. Increased estrogen levels caused decreased fibroblast proliferation and collagen synthesis in cell cult
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Daniel, Andrea R., Angela L. Gaviglio, Todd P. Knutson, Julie H. Ostrander, Douglas Yee, and Carol A. Lange. "Abstract 3572: Unliganded progesterone receptors augment estrogen-induced growth of breast cancer cells via co-regulation of estrogen receptor target genes." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3572.

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Lichtenfels, Martina, Gilberto Schwartsmann та Stefan Wiemann. "ESTROGEN RECEPTOR β AND AS A POSSIBLE BIOMARKER OF TAMOXIFEN RESISTANCE". У Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1048.

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Introduction: Approximately two-thirds of all breast cancer patients overexpress hormonal receptors and are treated with endocrine therapy, being tamoxifen (TAM) the standard treatment. However, many of the initial responders to TAM as first-line experience relapse. Several mechanisms have been proposed to explain the occurrence of acquired TAM resistance. Previous studies showed that estrogen receptor β (ERβ) expression is associated with better response to tamoxifen treatment, as the co-expression of ERα and ERβ is associated with TAM antiproliferative effects. Moreover, there is a growing i
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Mladenović, Milan P., Nevena M. Tomašević, Sanja Lj Matić, Tamara M. Mladenović, and Rino Ragno. "Computer-aided design of new drugs against breast cancer." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.641m.

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Computational medicinal chemistry, if used properly and in accordance with the available experimental data, may provide significant support to rational drug design. Herein, an overview of the computational approaches that have been applied to an estrogen receptor α (ERα) and endowed in the rational design of pM ERα antagonists with profound anti-breast cancer activity either in vitro or in vivo, will be presented. ERα is a 17β-estradiol inducible transcriptional regulator that initiates the RNA polymerase II-dependent transcriptional machinery, pointed for breast cancer (BC) development via ei
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Reports on the topic "Receptors to estrogens"

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DeSombre, E. R., R. C. Mease, A. Hughes, P. V. Harper, O. T. DeJesus, and A. M. Friedman. Bromine-80m-labeled estrogens: Auger-electron emitting, estrogen receptor-directed ligands with potential for therapy of estrogen receptor positive cancers. Office of Scientific and Technical Information (OSTI), 1988. http://dx.doi.org/10.2172/6347502.

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DiRenzo, James. Inhibition of Estrogen Receptor Action by the Orphan Receptors, SHP and DAX-1. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada403608.

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DiRenzo, James. Inhibition of Estrogen Receptor Action by the Orphan Receptors, SHP and DAX-1. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada412765.

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DiRenzo, James. Inhibition of Estrogen Receptor Action by the Orphan Receptors, SHP and DAX-1. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada419517.

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Direnzo, James. Inhibition of Estrogen Receptor Action by the Orphan Receptors, SHP and DAX-1. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada393316.

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Lubahn, Dennis B. Breast Cancer Associated Estrogen Receptors: Catechol Estrogen Receptors in ER-Minus Mice. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada396453.

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Lubahn, Dennis B. Breast Cancer Associated Estrogen Receptors: Catechol Estrogen Receptors in ER-Minus Mice. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada391322.

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Garabedian, Michael J. Factors Modulating Estrogen Receptor Activity. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada357985.

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Garabedian, Michael. Factors Modulating Estrogen Receptor Activity. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada391157.

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Garabedian, Michael J. Factors Modulating Estrogen Receptor Activity. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada381691.

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