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Journal articles on the topic 'Recipient model'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Fast, LD, CR Valeri, and JP Crowley. "Immune responses to major histocompatibility complex homozygous lymphoid cells in murine F1 hybrid recipients: implications for transfusion-associated graft-versus-host disease." Blood 86, no. 8 (1995): 3090–96. http://dx.doi.org/10.1182/blood.v86.8.3090.3090.

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Abstract Graft-versus-host disease (GVHD) is currently encountered after bone marrow transplantation and transfusion. GVHD associated with transfusion (TA-GVHD) in apparently immunocompetent recipients has been recently reported with increasing frequency. A consistent finding in many of these cases is that the recipient received blood from a donor homozygous for one of the recipient's HLA haplotypes. However, the observed frequency of TA-GVHD is much lower than the estimated probability of this donor/recipient combination. The potential role of recipient immune responses in controlling TA-GVHD

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2

Fast, LD, CR Valeri, and JP Crowley. "Immune responses to major histocompatibility complex homozygous lymphoid cells in murine F1 hybrid recipients: implications for transfusion-associated graft-versus-host disease." Blood 86, no. 8 (1995): 3090–96. http://dx.doi.org/10.1182/blood.v86.8.3090.bloodjournal8683090.

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Graft-versus-host disease (GVHD) is currently encountered after bone marrow transplantation and transfusion. GVHD associated with transfusion (TA-GVHD) in apparently immunocompetent recipients has been recently reported with increasing frequency. A consistent finding in many of these cases is that the recipient received blood from a donor homozygous for one of the recipient's HLA haplotypes. However, the observed frequency of TA-GVHD is much lower than the estimated probability of this donor/recipient combination. The potential role of recipient immune responses in controlling TA-GVHD was inve

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3

Zheng, Yama W. L., K. C. Allen Chan, Hao Sun, et al. "Nonhematopoietically Derived DNA Is Shorter than Hematopoietically Derived DNA in Plasma: A Transplantation Model." Clinical Chemistry 58, no. 3 (2012): 549–58. http://dx.doi.org/10.1373/clinchem.2011.169318.

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Abstract BACKGROUND Plasma DNA is predominantly hematopoietic in origin. The size difference between maternal- and fetal-derived DNA in maternal plasma prompted us to investigate whether there was any discrepancy in molecular size between hematopoietically and nonhematopoietically derived DNA in plasma. METHODS Plasma DNA samples from 6 hematopoietic stem cell transplant recipients and 1 liver transplant recipient were analyzed by massively parallel paired-end sequencing. The size of each fragment was deduced from the alignment positions of the paired reads. In sex-mismatched transplant recipi

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Teipel, Raphael, Johannes Schetelig, Michael Kramer, et al. "Prediction of Hematopoietic Stem Cell Yield after Mobilization with GCSF in Healthy Unrelated Donors." Blood 124, no. 21 (2014): 1128. http://dx.doi.org/10.1182/blood.v124.21.1128.1128.

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Abstract Introduction: The collection of hematopoietic stem cells from the peripheral blood in healthy donors has been established as a highly efficient method in clinical practice. Nevertheless, there are some donors who mobilize poorly despite adequate mobilization regimes. Several factors influencing the process of stem cell mobilization have previously been discussed in the literature. Methods: In total, the data of 7.216 unrelated donors who underwent GCSF-induced stem cell mobilization and collection in two German apheresis centers between July 1997 and August 2012 were retrospectively r

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Onishchenko, N. A., A. O. Nikolskaya, Z. Z. Gonikova, L. A. Kirsanova, M. Yu Shagidulin, and V. I. Sevastianov. "Regenerative and hepatospecific activity of total RNA from xenogenic bone marrow cells." Russian Journal of Transplantology and Artificial Organs 23, no. 1 (2021): 43–48. http://dx.doi.org/10.15825/1995-1191-2021-1-43-48.

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Objective: to study the peculiarities of the induction effect of total RNA (tRNA) from xenogenic bone marrow cells (BMCs) on regeneration processes in the recipient's native liver with extensive liver resection using an adoptive transfer model. Materials and methods. The study was carried out on an adoptive transfer model using male Wistar rats (n = 20) and guinea pigs (n = 17). The donors were rats (n = 10). 12 hours after extensive liver resection (70-75%), tRNA was isolated from BMCs and injected into intact (non-operated) recipients intraperitoneally at a dose of 30 μg/100 g of weight. The

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6

Heinemann, Jack A., Heidi E. Scott, and Meredith Williams. "Doing the Conjugative Two-step: Evidence of Recipient Autonomy in Retrotransfer." Genetics 143, no. 3 (1996): 1425–35. http://dx.doi.org/10.1093/genetics/143.3.1425.

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Abstract Bidirectional exchange of genetic information, called retrotransfer, during bouts of bacterial conjugation has drawn the interest of those concerned with the risk of releasing genetically engineered microbes, the fluidity of genes among species, and the mechanism of DNA transport between cells. The phenomenon has generated two models in explanation, both of which yield highly testable predictions. The first model, called the one-step, predicts that the flow of genes from recipient bacteria to donor bacteria is mechanistically distinct from, but dependent on, conjugation between donors

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Xu, Yajing, Heather F. Johnston, Stephen J. Forman, and Defu Zeng. "Oral Administration of Ibrutinib Is Ineffective at Preventing Scleroderma in Chronic Gvhd in Two Preclinical Mouse Models." Blood 124, no. 21 (2014): 3818. http://dx.doi.org/10.1182/blood.v124.21.3818.3818.

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Abstract We have established two mouse models of chronic graft versus host disease (cGVHD): one is an MHC-matched DBA/2 donor to BALB/c recipient, and this model amplifies the role of CD4+ T and B cells in transplants; the other model is an MHC-mismatched C57BL/6 donor to BALB/c recipient, and this model amplifies the role of de novo-developed CD4+ T and B cells. BALB/c recipients in both models started to develop scleroderma ~35 days after transplantation of donor spleen and bone marrow cells and this peaked ~50 days after transplantation. BALB/c recipients given DBA/2 transplants also develo

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Hendrickson, Jeanne E., Nicole H. Smith, Kathryn R. Girard-Pierce, et al. "Development of a Murine Model of Weak Kel: Similarities to Weak Rh(D)." Blood 120, no. 21 (2012): 842. http://dx.doi.org/10.1182/blood.v120.21.842.842.

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Abstract Abstract 842 Introduction: Aspects of RBC antigens that define their immunogenicity are not fully understood. Multiple studies in humans have demonstrated Rh(D) to be the most immunogenic RBC antigen, yet the same antigen present in lower copy number (weak Rh(D)) is, with rare exception, considered non-immunogenic. A better understanding of factors influencing RBC alloimmunogenicity would be helpful in predicting antibody responses in transfusion and pregnancy situations alike, as well as in managing donor RBC inventory. Herein, we describe the generation of transgenic mice with diffe

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9

Toomey, Niamh, ï¿½ine Monaghan, Sï¿½amus Fanning, and Declan Bolton. "Transfer of Antibiotic Resistance Marker Genes between Lactic Acid Bacteria in Model Rumen and Plant Environments." Applied and Environmental Microbiology 75, no. 10 (2009): 3146–52. http://dx.doi.org/10.1128/aem.02471-08.

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ABSTRACT Three wild-type dairy isolates of lactic acid bacteria (LAB) and one Lactococcus lactis control strain were analyzed for their ability to transfer antibiotic resistance determinants (plasmid or transposon located) to two LAB recipients using both in vitro methods and in vivo models. In vitro transfer experiments were carried out with the donors and recipients using the filter mating method. In vivo mating examined transfer in two natural environments, a rumen model and an alfalfa sprout model. All transconjugants were confirmed by Etest, PCR, pulsed-field gel electrophoresis, and Sout

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10

Slichter, Sherrill J., Esther Pellham, S. Lawrence Bailey, et al. "Leukofiltration plus pathogen reduction prevents alloimmune platelet refractoriness in a dog transfusion model." Blood 130, no. 8 (2017): 1052–61. http://dx.doi.org/10.1182/blood-2016-07-726901.

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Key Points Eight weekly transfusions of F-LR + pathogen-reduced donor platelets were accepted by 31 of 32 (97%) recipient dogs. Among accepting recipients, none developed lymphocyte and only 2 had platelet antibodies not associated with platelet refractoriness.

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11

Fac-Beneda, Joanna. "Lakes in the cascade model of storage and drainage reservoirs." Limnological Review 11, no. 4 (2011): 143–50. http://dx.doi.org/10.2478/v10194-011-0036-y.

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Lakes in the cascade model of storage and drainage reservoirsThe study area covers a compact, decentric hydrographic system called the Kashubian hydrographic system, which includes the drainage basins of the Słupia, Łupawa, Łeba, Reda, Wda, Wierzyca and Radunia. The Kashubian hydrographic system can be presented in the form of a cascade model of storage-drainage reservoirs - kord. One of the properties of a hydrographic system is its extent. Its horizontal extent is delimited by topographic watersheds, and its vertical extent is delimited at the bottom by the surface of the drainage base and i

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Markey, Kate A., Rachel D. Kuns, Renee J. Robb, et al. "Recipient CD8+ DC Delete Alloreactive Donor CTL and Promote Leukemic Relapse after Allogeneic BMT." Blood 126, no. 23 (2015): 4279. http://dx.doi.org/10.1182/blood.v126.23.4279.4279.

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Abstract Allogeneic bone marrow transplantation (BMT) remains the therapy of choice for many haematological malignancies, but despite the curative benefit of the immunological graft-versus-leukemia (GVL) effect, relapse remains a key cause of death. We have investigated the role of recipient dendritic cells (DC) in antigen presentation to donor CD8 cytotoxic T cells (CTL) in a model of BMT where GVHD and GVL are directed to multiple minor histocompatibility antigens (mHA) and survival reflects GVL activity. C3H.Sw bone marrow and purified CD8 T cell grafts were transplanted with B6-derived MLL

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Rosinski, Steven Lawrence, Scott Stoll Graves, Rainer Storb, and Brad Stone. "Vaccinating Female Donors with Y Chromosome-Encoded Disparities in the Pre-Clinical Canine Model of Allogeneic Hematopoietic Cell Transplantation." Blood 120, no. 21 (2012): 4123. http://dx.doi.org/10.1182/blood.v120.21.4123.4123.

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Abstract Abstract 4123 Adoptive transfer of tumor antigen-sensitized lymphocytes has been a long-studied approach for the treatment of solid malignancies. Transfer of lymphocytes sensitized against minor histocompatibility (H) antigens, disparate between the marrow donor and recipient, may be a similar approach to enable improved host versus tumor responses in the treatment of hematological malignancies. We have developed a pre-clinical canine transplant model that establishes a state of stable mixed donor-recipient hematopoietic chimerism after a non-myeloablative conditioning regimen, dog le

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14

Shao, Jia, Chenyu Wang, Peng Fu, Fan Chen, Yi Zhang, and Jinxia Wei. "Impact of Donor and Recipient CYP3A5*3 Genotype on Tacrolimus Population Pharmacokinetics in Chinese Adult Liver Transplant Recipients." Annals of Pharmacotherapy 54, no. 7 (2019): 652–61. http://dx.doi.org/10.1177/1060028019897050.

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Background: Tacrolimus (TAC) is widely used after liver transplantation, but the therapeutic window is narrow. Objective: The purpose was to study both donor and recipient CYP3A5*3 genotypes affecting TAC apparent clearance rate (CL/F) and investigate a TAC population pharmacokinetic (PPK) model in Chinese liver transplant recipients for potential starting-dose individualized medication. Methods: A data set of 721 TAC concentrations was obtained from 43 adult liver transplant recipients. The TAC PPK model was analyzed using nonlinear mixed-effects modeling. Potential covariates, including demo

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15

Beltrame, Renato Travassos, Luis Gustavo Barioni, Breno Dala Maestri, and Celia Raquel Quirino. "Economic optimization of the number of recipients in bovine embryo transfer programs." Scientia Agricola 64, no. 3 (2007): 221–26. http://dx.doi.org/10.1590/s0103-90162007000300002.

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Purchase and maintenance of recipient females account for a large proportion of the costs and determine the number of calves that can be produced in an embryo transfer program. However, the large variability of embryo production by the donors and the need to purchase and synchronize the recipients before knowing the number of embryos collected make it difficult for the decision maker to identify the ideal number of recipient females to allocate. An ex-ante evaluation to determine the optimal number of recipient females was carried out through a sensitivity analysis for the ratio between the nu

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16

Cho, Jinmyoung, and Alan Stevens. "The Relationship Between Functional Decline of Care Recipients and Health of Caregivers." Innovation in Aging 4, Supplement_1 (2020): 361. http://dx.doi.org/10.1093/geroni/igaa057.1161.

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Abstract Pearlin’s stress-process model (2010) depicts that functional decline in care-recipient would shape caregiving burden and impact on caregiver’s health. With this background, we explored how the changes in care-recipients’ physical and cognitive functioning are related to the caregivers’ physical health. A total of 853 care-recipients from the Rounds 1 and 5 of the National Health and Aging Trend Study (NHATS) and their 1,303 caregivers from Round 5 of National Study of Caregiving (NSOC) were included. Multiple regression analyses were conducted to identify correlates of self-rated hea

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17

Mathes, David, Scott Stoll Graves, George E. Georges, et al. "Long-Term Tolerance to Kidney Allografts After Induced Rejection of Donor Hematopoietic Chimerism in a Preclinical Canine Model." Blood 120, no. 21 (2012): 2991. http://dx.doi.org/10.1182/blood.v120.21.2991.2991.

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Abstract Abstract 2991 Allogeneic hematopoietic cell transplantation provides a reliable method for inducing tolerance towards solid organ grafts. However, this procedure can result in graft-versus-host disease (GVHD) thereby limiting its application. Here we test the hypothesis that mixed chimerism can be intentionally reverted to host hematopoiesis without rejection of a kidney graft. Recipient dogs were given 2 Gy total body irradiation (TBI) before and a short course of immunosuppression after marrow infusion from dog leukocyte antigen-identical littermates. All dogs achieved stable mixed

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David, André Ibrahim, Valéria Vieira Chida, Andre Dong Won Lee, et al. "Multivisceral transplantation in pigs: a model for research and training." Einstein (São Paulo) 9, no. 3 (2011): 372–76. http://dx.doi.org/10.1590/s1679-45082011ao1956.

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ABSTRACT Objective: To present a model for research and training in multivisceral transplantation in pigs. Methods: Eight Large White pigs (four donors and four recipients) were operated. The multivisceral transplant with stomach, duodenum, pancreas, liver and intestine was performed similarly to transplantation in humans with a few differences, described below. Anastomoses were performed as follows: end-to-end from the supra-hepatic vena cava of the graft to the recipient juxta diaphragmatic vena cava; end-to-end from the infra-hepatic vena cava of the graft to the inferior (suprarenal) vena

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Dueñas-Jurado, J. M., P. A. Gutiérrez, A. Casado-Adam, et al. "New models for donor-recipient matching in lung transplantations." PLOS ONE 16, no. 6 (2021): e0252148. http://dx.doi.org/10.1371/journal.pone.0252148.

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Objective One of the main problems of lung transplantation is the shortage of organs as well as reduced survival rates. In the absence of an international standardized model for lung donor-recipient allocation, we set out to develop such a model based on the characteristics of past experiences with lung donors and recipients with the aim of improving the outcomes of the entire transplantation process. Methods This was a retrospective analysis of 404 lung transplants carried out at the Reina Sofía University Hospital (Córdoba, Spain) over 23 years. We analyzed various clinical variables obtaine

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Ugai, Tomotaka, Keitaro Matsuo, and Yasuo Morishima. "ALDH2 Polymorphism Has a Significant Impact on Transplant Related Mortality after HLA-Matched Bone Marrow Transplantation." Blood 128, no. 22 (2016): 3391. http://dx.doi.org/10.1182/blood.v128.22.3391.3391.

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Abstract Background : Aldehyde dehydrogenase 2 (ALDH2), a mitochondrial enzyme known to degrade acetaldehyde metabolized from ethanol, is also involved in critically important biological processes such as drug metabolism and DNA repair in hematopoietic stem cells. Based on its role in these biological processes, we hypothesized that a functional ALDH2Glu504Lys polymorphism, which is highly prevalent in East Asian populations, could affect the outcome of hematopoietic transplant recipients. Here, we investigated the association between recipient and donor ALDH2 polymorphism and the clinical out

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Slichter, Sherrill J., Esther Pellham, S. Lawrence Bailey, and Todd Christoffel. "Filtration Leukoreduction Followed by Pathogen-Reduction (Mirasol Treatment) Prevents Alloimmune Platelet Refractoriness in a Dog Platelet Transfusion Model." Blood 120, no. 21 (2012): 271. http://dx.doi.org/10.1182/blood.v120.21.271.271.

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Abstract Abstract 271 Background: The largest transfusion (tx) trial to evaluate methods of preventing platelet (plt) alloimmunization (TRAP Trial; NEJM 1997;337:1861) demonstrated residual alloimmunization rates of 17% to 21% in AML patients (pts) undergoing induction chemotherapy despite receiving either filter-leukoreduced (F-LR) or UV-B irradiated (UV-BI) blood products, respectively. Our pre-clinical dog plt tx studies, the basis for testing UV-BI in the TRAP Trial, demonstrated this model was able to predict pt results; i.e., prevention of alloimmunization was 45% in the dog but 79% in p

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Fast, Loren D. "Recipient elimination of allogeneic lymphoid cells: donor CD4+ cells are effective alloantigen-presenting cells." Blood 96, no. 3 (2000): 1144–49. http://dx.doi.org/10.1182/blood.v96.3.1144.

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Abstract The encounter with allogeneic major histocompatibility complex (MHC) molecules expressed on donor leukocytes during transfusion of blood products has been shown to impact the recipient's immune responses in a number of settings. To better understand the responses induced by the transfer of allogeneic cells, a murine model was used to characterize the recipient responses that control the fate of the allogeneic lymphoid cells. Recipient CD8+ cells could rapidly eliminate a large number of donor cells within 3 days after injection. When elimination responses were studied in the absence o

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Fast, Loren D. "Recipient elimination of allogeneic lymphoid cells: donor CD4+ cells are effective alloantigen-presenting cells." Blood 96, no. 3 (2000): 1144–49. http://dx.doi.org/10.1182/blood.v96.3.1144.015k46_1144_1149.

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The encounter with allogeneic major histocompatibility complex (MHC) molecules expressed on donor leukocytes during transfusion of blood products has been shown to impact the recipient's immune responses in a number of settings. To better understand the responses induced by the transfer of allogeneic cells, a murine model was used to characterize the recipient responses that control the fate of the allogeneic lymphoid cells. Recipient CD8+ cells could rapidly eliminate a large number of donor cells within 3 days after injection. When elimination responses were studied in the absence of CD8+ ce

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24

Cohen, S. I. "Allocation of Foreign Aid in a Segmented International Context." Pakistan Development Review 34, no. 4III (1995): 987–1000. http://dx.doi.org/10.30541/v34i4iiipp.987-1000.

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Research on the topic of distribution of foreign aid among recipients is regaining momentum. This is understandable in the light of the knowledge that presently the richest 40 percent of the developing world receives twice as much aid per capita as the poorest 40 percent [UNDP (1994)], while once upon a time foreign aid was sought to accomplish exactly the opposite. The distribution of official development assistance (ODA) is conventionally studied in terms of two models: the ‘recipient needs’ model and the ‘donor interest’ model. In the first, foreign aid flows are seen to satisfy the socio-e

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van den Wijngaard, Jeroen P. H. M., Asli Umur, Raymond T. Krediet, Michael G. Ross, and Martin J. C. van Gemert. "Modeling a hydropic recipient twin in twin-twin transfusion syndrome." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 4 (2005): R799—R814. http://dx.doi.org/10.1152/ajpregu.00635.2004.

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We developed a mathematical model of twin-twin transfusion syndrome (TTTS) that includes a hydropic recipient twin, adding interstitial and intracellular fluid compartments, fetal congestive cardiac failure, and the dynamics of renin-angiotensin system (RAS) mediators to our previous TTTS model. Ten differential equations for each twin, coupled by the net fetofetal transfusion of blood and blood components, i.e., colloids, osmoles, and RAS mediators, describe the development of fetal arterial and venous blood volumes, blood osmolality and colloid osmotic pressure (COP), interstitial fluid volu

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Chou, Shih Yung, Charles Ramser, and Tree Chang. "When is helping considered helping? The recipient’s view of helping during the stages of receiving help." International Journal of Organization Theory & Behavior 22, no. 1 (2019): 79–95. http://dx.doi.org/10.1108/ijotb-03-2018-0034.

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PurposeThe purpose of this paper is to develop a theoretical model that describes when helping is considered helping from the recipient’s point of view.Design/methodology/approachThe theoretical model was conceptually developed by drawing upon attribution theory, self-consistency theory and social cognitive theory, as well as relevant literature.FindingsThe authors propose that receiving help encompasses three sequential stages: the pre-help-receiving stage, the help-receiving stage and the post-help-receiving stage. Additionally, the authors theorize that the more other-oriented helping motiv

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Kim, Yeunhee, Danielle Turner, Jacquelyn Nelson, Ina Dobrinski, Margaret McEntee, and Alexander J. Travis. "Production of donor-derived sperm after spermatogonial stem cell transplantation in the dog." REPRODUCTION 136, no. 6 (2008): 823–31. http://dx.doi.org/10.1530/rep-08-0226.

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Spermatogonial stem cell transplantation (SSCT) offers unique approaches to investigate SSC and to manipulate the male germline. We report here the first successful performance of this technique in the dog, which is an important model of human diseases. First, we investigated an irradiation protocol to deplete endogenous male germ cells in recipient testes. Histologic examination confirmed >95% depletion of endogenous spermatogenesis, but retention of normal testis architecture. Then, 5-month-old recipient dogs (n=5) were focally irradiated on their testes prior to transplantation with mixe

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Leow, C. K., D. W. R. Gray, and P. J. Morris. "Successful Reversal of Diabetes by Single Donor Isologous Islet Transplantation in a Mouse Model." Cell Transplantation 6, no. 4 (1997): 429–30. http://dx.doi.org/10.1177/096368979700600410.

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A method for isolating mouse islets which consistently gives a high yield with good purity is described. Using a bovine serum albumin gradient, the mean yield of islets per pancreas is 425 (SEM ± 15) with a consistent purity of over 90%. Single donor to single recipient of islets transplanted under the renal capsule restores normoglycemia in the diabetic recipients within 2 to 5 days of transplantation.

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Enghofer, Michael, Jörg Bojunga, Ralf Ludwig, et al. "Lymphocyte transfer in streptozotocin-induced diabetes: adhesion of donor cells to islet endothelium." American Journal of Physiology-Endocrinology and Metabolism 274, no. 5 (1998): E928—E935. http://dx.doi.org/10.1152/ajpendo.1998.274.5.e928.

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The interaction between intravenously transferred lymphocytes derived from spleens of multiple low-dose streptozotocin-diabetic mice with islet, exocrine pancreatic, and gastric mucosal endothelium of nondiabetic recipient mice was investigated by in vivo microscopy. Donor lymphocytes were stained with acridine red in vitro. The adoptive transfer of these cells from diabetic donor animals resulted in significantly increased lymphocyte rolling (4.46 ± 1.32%, P < 0.05) and adhesion (3.86 ± 1.04%, P < 0.05) in islets of nondiabetic recipients that had been pretreated with a single subdiabet

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Yang, Jingyan, Christine L. Sardo Molmenti, Joaquin Cagliani, et al. "Time-Effect of Donor and Recipient Characteristics on Graft Survival after Kidney Transplantation." International Journal of Angiology 28, no. 04 (2019): 249–54. http://dx.doi.org/10.1055/s-0039-1700500.

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AbstractThe kidney allocation system (KAS) is based on quality-based “longevity matching” strategies that provide only a momentary snapshot of expected outcomes at the time of transplantation. The purpose of our study was to define on a continuous timeline the relative and mutual interactions of donor and recipient characteristics on graft survival.Total 39,108 subjects who underwent kidney transplant between October 25, 1999 and January 1, 2007 were identified in the United Network for Organ Sharing dataset. Our primary outcome was graft survival. Time-dependent receiver operating characteris

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Dreher, Axel, Jenny Simon, and Justin Valasek. "Optimal decision rules in multilateral aid funds." Review of International Organizations 16, no. 3 (2021): 689–719. http://dx.doi.org/10.1007/s11558-020-09406-w.

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AbstractWhile existing research has suggested that delegating foreign aid allocation decisions to a multilateral aid fund may incentivize recipient countries to invest in bureaucratic quality, our analysis links the fund’s decision rules to recipient-country investment by explicitly modeling the decision-making within multilateral aid funds. We find that majority rule induces stronger competition between recipients, resulting in higher investments in bureaucratic quality. Despite this advantage, unanimity can still be optimal since the increased investment under majority comes at the cost of l

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Hagihara, Atsushi, Fumiko Harada, and Hiromitsu Shimakawa. "Estimation of posture and prediction of the elderly getting out of bed using a body pressure sensor." International Journal of Electrical and Computer Engineering (IJECE) 11, no. 2 (2021): 1208. http://dx.doi.org/10.11591/ijece.v11i2.pp1208-1222.

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We propose an IoT support system for estimating the posture of the care recipient on the bed from the body pressure of the care recipient measured by a sheet-type body pressure sensor, and detecting the posture related to leaving the bed in real time. In addition, we propose a method that predicts getting out of the bed before the care recipient takes a posture related to getting out of the bed by considering the state transition. Intervention experiment showed that using body pressure features as an explanatory variable and applying machine learning, 16 types of postures on the bed of care re

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Hamidi, Ichsan, Suhel Suhel, and Abdul Latif. "The effectivities of zakat productive funds toward zakat recipient income in Palembang." Jurnal Ekonomi Pembangunan 17, no. 1 (2019): 24–30. http://dx.doi.org/10.29259/jep.v17i1.8965.

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This study to investigate effectivities of zakat productive funds toward zakat recipient income in Palembang. Data using primary data which collect through interviews, observation, and documentation with instruments a questionnaire. The method in this study uses the quantitative approach with applying a regression model. The population in this study are all the recipients who receive the funding of zakat productive from BAZNAS of South Sumatra. The findings of this study indicated that the capital of zakat productive, length of business and training has a significant effect on zakat recipient

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Li, Hongmei, Daniel Kaplan, Anthony Jake Demetris, Jennifer McNiff, Mark Shlomchik, and Warren D. Shlomchik. "Recipient Langerhans Cells Are Neither Required Nor Sufficient for GVHD Induction in MHC-Matched Allogeneic BMT, but a Langerin+ Cell Is a Pivotal Regulator of Langerhans Cell Turnover Post Transplantation." Blood 112, no. 11 (2008): 3511. http://dx.doi.org/10.1182/blood.v112.11.3511.3511.

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Abstract Graft-versus-host disease (GVHD) is initiated when alloreactive donor T cells are primed by professional antigen-presenting cells (APCs) to undergo clonal expansion and maturation. Host APCs that survive pretransplant conditioning play an essential role in this T cell activation, and are an attractive target for GVHD prevention and treatment. However, APCs are diverse in phenotype, location and function and an understanding of the roles of distinct subsets is an important first step in developing APC-targeted therapies. Skin is the most frequently affected organ in GVHD. Langerhans ce

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Zengin, Hüseyin, and Abdurrahman Korkmaz. "Determinants of Turkey’s foreign aid behavior." New Perspectives on Turkey 60 (May 2019): 109–35. http://dx.doi.org/10.1017/npt.2019.1.

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AbstractThis paper analyzes a hundred Turkish aid recipient countries in order to explore the determinants of Turkey’s foreign aid behavior during the period 2005–2016. By estimating the model with the system-GMM estimator, it is demonstrated that Turkey is a regular donor whose amount of foreign aid is positively influenced by the export-based embeddedness of Turkish firms in the recipient countries. Recipients with low levels of per-capita income attract more Turkish aid. However, this income’s effect diminishes in states that were formerly part of Ottoman territory. Recipient countries in a

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Kim, Dong-hwan, Do-hun Kim, Hyun Seok Kim, Seong-il Kim, and Dong-Ho Lee. "Determinants of Bilateral REDD+ Cooperation Recipients in Kyoto Protocol Regime and Their Implications in Paris Agreement Regime." Forests 11, no. 7 (2020): 751. http://dx.doi.org/10.3390/f11070751.

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A cooperative approach for REDD+ between developing and developed countries can be a sound means to achieve national and global mitigation targets. To accomplish the Nationally Determined Contribution (NDC) of countries and the global 2 °C climate target more effectively, it is necessary to explore the coordination options, based on the understanding of bilateral REDD+ cooperation. This study explains the current status of bilateral REDD+ cooperation and investigates determinants affecting REDD+ recipient decisions of donor countries, by analyzing bilateral REDD+ arrangements, which has been p

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Biswas, Chandra, Daniel Rittenberg, Xiaoling Luo, et al. "Double Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) Results In Successful Engraftment of Bone Marrow From Both Donors without Graft Versus Host or Graft Versus Graft Effects." Blood 116, no. 21 (2010): 1453. http://dx.doi.org/10.1182/blood.v116.21.1453.1453.

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Abstract Abstract 1453 The use of haploidentical donors extends the potential clinical application of HSCT. However, relapse of resistant malignancy contributes to low success rates in high risk patients. Relapse may be due to the ability of leukemic cells to immunologically escape a single donor's GVL effects. We hypothesized that the use of two haploidentical donors, each targeting a different recipient haplotype, will increase anti- leukemia activity after double haploidentical SCT. We performed murine studies to establish new single haploidentical (SH) and double-haploidentical (DH) murine

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Gupta, Sanjay, Harvey M. Rappaport, and Lonnie T. Bennett. "Polypharmacy among Nursing Home Geriatric Medicaid Recipients." Annals of Pharmacotherapy 30, no. 9 (1996): 946–50. http://dx.doi.org/10.1177/106002809603000905.

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OBJECTIVE: To determine the factors that influence the number of different drugs prescribed to geriatric Medicaid recipients residing in Louisiana's intermediate care facilities I (ICFs I). DESIGN: Observational and cross-sectional with descriptive and analytic components. PARTICIPANTS: All geriatric Medicaid recipients in Louisiana ICFs I during 1994 (n= 19 932). METHODS: Relevant data on sex, age, race, geographic region of a recipient, number of prescribing physicians, number of pharmacies used, and the number of drugs prescribed to a recipient were extracted from the state Medicaid files.

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Jiang, Qianli, Yan-yan Ye, Le-zhong Yuan, et al. "Study Of Stem Cell Homing and Donor-Recipient Cellular Interaction In Allogenic Hematopoietic Stem Cell Transplantation Mice Model." Blood 122, no. 21 (2013): 5424. http://dx.doi.org/10.1182/blood.v122.21.5424.5424.

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Abstract Background Allogeneic hematopoietic stem cell transplantation is an effective method for treatment of hematological malignancies, while GVHD and graft rejection are main complications, which seriously affect patients' survival rates and quality of life. Aim Establishing allo-transplantation mice model with mRFP and GFP transgenic mice, to simulate clinical hematopoietic stem cell transplantation and explore the mechanism of stem cell homing and GVHD. Methods 1) Thirteen C57BL/6 GFP transgenic mice, used as recipients, were irradiated with 7 Gy. Each mouse was injected through caudal v

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Girod, Desha M., and Jennifer L. Tobin. "Take the Money and Run: The Determinants of Compliance with Aid Agreements." International Organization 70, no. 1 (2016): 209–39. http://dx.doi.org/10.1017/s0020818315000326.

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AbstractConditions on aid agreements aim to increase aid effectiveness, and are, therefore, an important component of aid agreements. Yet little is known about why aid-recipient governments comply with these conditions. Some scholars have suggested a strategic-importance hypothesis: recipients comply when donors enforce conditions—and donors enforce conditions when recipients are not strategically important. However, there are many cases where strategically important countries comply with conditions and strategically unimportant countries fail to do so. We argue that to explain compliance, we

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Zhao, Xiangyu, Yingjun Chang, Ling-Ling Xu, et al. "Lacking Of Missing Killer-Immunoglobulin-Like Receptor Ligand In Recipients Can Predict Better Prognosis After HLA-Mismatched/Haploidentical Transplantation Without T Cells Depletion In Vitro In Chronic Myeloid Leukemia Patients." Blood 122, no. 21 (2013): 2165. http://dx.doi.org/10.1182/blood.v122.21.2165.2165.

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Abstract Introduction HLA-mismatched/haploidentical stem cell transplantation (SCT) is a feasible therapeutic option for advanced hematologic malignancies patients who lack an HLA-matched related or unrelated donor. The effect of NK alloreactivity in HLA haploidentcial SCT is still under debate and in particular in transplantation for chronic myeloid leukemia (CML) the data are very limited and with conflicting outcome.The goal of this study was to explorethe predictive roles of missing self model in our HLA-mismatched/haploidentical transplantation without T-cell-depletion in vitro in chronic

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Rowe, Vanessa, Tatjana Banovic, Kelli P. MacDonald, et al. "Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation." Blood 108, no. 7 (2006): 2485–92. http://dx.doi.org/10.1182/blood-2006-04-016063.

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Abstract Host antigen-presenting cells (APCs) are known to be critical for the induction of graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT), but the relative contribution of specific APC subsets remains unclear. We have studied the role of host B cells in GVHD by using B-cell–deficient μMT mice as BMT recipients in a model of CD4-dependent GVHD to major histocompatibility complex antigens. We demonstrate that acute GVHD is initially augmented in μMT recipients relative to wild-type recipients (mortality: 85% vs 44%, P < .01), and this is the result of an

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Davis, Joanne E., Michael Harvey, Nicholas A. Gherardin, et al. "A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation and Onset of Gvhd." Blood 124, no. 21 (2014): 3805. http://dx.doi.org/10.1182/blood.v124.21.3805.3805.

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Abstract Introduction Immunosuppressive pre-transplantation conditioning is essential for donor cell engraftment in allogeneic bone marrow transplant (BMT). The role of residual post-conditioning recipient immunity in determining engraftment is poorly understood. Although recipient perforin has previously been shown to modulate myeloid engraftment from mouse bone marrow, and adoptive transfer of natural killer (NK) cells can ameliorate the onset of graft-versus host disease (GVHD), the role of perforin-expressing endogenous recipient NK and NKT cells in modulating donor T cell engraftment has

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Weiler, Florian, and Franklins A. Sanubi. "Development and Climate Aid to Africa: Comparing Aid Allocation Models for Different Aid Flows." Africa Spectrum 54, no. 3 (2019): 244–67. http://dx.doi.org/10.1177/0002039720905598.

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This article examines the role different aid allocation models play not only for conventional development aid but also for two new financial flows, adaptation and mitigation aid. We first test the three models proposed in the literature – recipient need, recipient merit, and donor interests – using the latest available aid data and compare our results with findings of older studies on Africa, and with studies on aid allocation on a global scale. We find that the recipient merit model in more recent years no longer plays a role for development aid allocation in Africa, in line with findings rep

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Slichter, Sherrill J., Kraig Abrams, Lakshmi Gaur, Karen Nelson, Esther Pellham, and Todd Christoffel. "Leukoreduction to Prevent Alloimmune Platelet (Plt) Refractoriness in a Dog Transfusion Model: Types of Residual White Blood Cells (WBCs) Directly Affect Transfusion Outcomes." Blood 104, no. 11 (2004): 835. http://dx.doi.org/10.1182/blood.v104.11.835.835.

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Abstract Introduction: Current practice assumes that just a quantitative reduction in the number of transfused wbcs to <1 to 5 x 106/transfusion is sufficient to prevent plt alloimmunization. However, our studies indicate that different leukoreduction strategies vary in their ability to remove immunizing wbcs, and this correlates with rates of alloimmune plt refractoriness in immunocompetent recipients. Experimental Design And Methods: Pairs of donor-recipient dogs were selected either at random, as having a shared DLA DR-B epitope, or as being specifically mismatched for this DLA locus. No

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Gibson, Christopher J., Haesook T. Kim, H. Moses Murdock, et al. "DNMT3A clonal Hematopoiesis in Older Donors Is Associated with Improved Survival in Recipients after Allogeneic Hematopoietic Cell Transplant." Blood 136, Supplement 1 (2020): 26. http://dx.doi.org/10.1182/blood-2020-142925.

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Background: Clonal hematopoiesis (CH) is an age-related condition in which somatic mutations can be detected in the blood of healthy individuals. In the non-transplant setting, CH is associated with an elevated risk of developing hematologic malignancy and an increased risk of non-hematologic outcomes due to altered inflammatory signaling. During hematopoietic cell transplantation (HCT), CH in older donors can engraft in recipients and could therefore influence outcomes through effects on graft immunologic function or by causing donor cell leukemia. A definitive link between donor CH and recip

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Amsar, Amsar, Rizal Munadi, and Ramzi Adriman. "SELEKSI BEASISWA UNTUK PERGURUAN TINGGI BERDASARKAN PENDEKATAN KEPUTUSAN BERKEADILAN DENGAN FUZZY MAMDANI." Jurnal Inotera 2, no. 2 (2018): 1. http://dx.doi.org/10.31572/inotera.vol2.iss2.2017.id28.

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The scholarship is one of the funding schemes of study in an education system. Various models and names of scholarship schemes are offered on terms that have been determined by the scholarship provider. The essence of these conditions is the trust and confidence of the funders of the scholarship recipients and is projected to complete the study period as per the allocated funds. In general, funders are very concerned about the issue of academic qualification as one of the main indicators. However, for prospective students who wish to pursue higher education from coming from orphaned families a

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Lundqvist, Andreas, Ramaprasad Srinivasan, Dante Suffredini, et al. "Potent Graft-Versus-Renal Cell Carcinoma (RCC) Effects in a Murine Minor Histocompatibility Antigen (mHa)-Mismatched Allogeneic Transplant Model." Blood 104, no. 11 (2004): 4982. http://dx.doi.org/10.1182/blood.v104.11.4982.4982.

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Abstract Donor immune-mediated anti-neoplastic effects make the greatest contribution to the durable disease remissions obtained in hematological malignancies following allogeneic hematopoietic cell transplantation (a-HCT). Recent studies have demonstrated that clinically meaningful graft-versus-tumor (GVT) effects can also be induced against select solid tumors following a-HCT. GVT effects have been most extensively documented in RCC, where response rates in the range of 20%–50% have been reported. Unfortunately, death from eventual disease progression and morbidity from graft-versus-host dis

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Grainger, John D., Lez J. Fairbairn, and Robert F. Wynn. "Murine Mesenchymal Stem Cells Improve Haemopoietic Engraftment in a Murine Transplant Model and Is Maximised through Osteogenic Stimulation." Blood 104, no. 11 (2004): 1183. http://dx.doi.org/10.1182/blood.v104.11.1183.1183.

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Abstract Several studies have preciously shown improved engraftment of human haemopoietic stem cells (HSC) following co-infusion of human mesenchymal stem cells (MSC). However, these studies have been criticised for using xenogeneic recipients which might support human haemopoiesis through the production of species-specific cytokines and growth factors by human MSC. To further investigate the potential for MSC to support HSC engraftment we used a murine to murine transplant model to co-infuse purified murine MSC and murine HSC. The MSC were derived from collagenase-treated bone fragments of th

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Roussel, Arnaud, Edouard Sage, Gilbert Massard, et al. "Impact of donor, recipient and matching on survival after high emergency lung transplantation in France." European Respiratory Journal 54, no. 5 (2019): 1900096. http://dx.doi.org/10.1183/13993003.00096-2019.

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IntroductionSince July 2007, the French high emergency lung transplantation (HELT) allocation procedure prioritises available lung grafts to waiting patients with imminent risk of death. The relative impacts of donor, recipient and matching on the outcome following HELT remain unknown. We aimed at deciphering the relative impacts of donor, recipient and matching on the outcome following HELT in an exhaustive administrative database.MethodsAll lung transplantations performed in France were prospectively registered in an administrative database. We retrospectively reviewed the procedures perform

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