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Journal articles on the topic 'Reclassification Traditional'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Esterling, Lisa, Ranjula Wijayatunge, Krystal Brown, et al. "Impact of a Cancer Gene Variant Reclassification Program Over a 20-Year Period." JCO Precision Oncology, no. 4 (September 2020): 944–54. http://dx.doi.org/10.1200/po.20.00020.

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PURPOSE Hereditary cancer genetic testing can inform personalized medical management for individuals at increased cancer risk. However, many variants in cancer predisposition genes are individually rare, and traditional tools may be insufficient to evaluate pathogenicity. This analysis presents data on variant classification and reclassification over a 20-year period. PATIENTS AND METHODS This is a retrospective analysis of > 1.9 million individuals who received hereditary cancer genetic testing from a single clinical laboratory (March 1997 to December 2017). Variant classification included

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Hernández-Camba, Alejandro, Marta Carrillo-Palau, Laura Ramos, et al. "Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk." Journal of Clinical Medicine 10, no. 8 (2021): 1671. http://dx.doi.org/10.3390/jcm10081671.

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The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD) into the very high-CV-risk category and whether this may be related to disease features. In this cross-sectional study encompassing 186 IBD patients and 175 controls, Systematic Coronary Risk Evaluation (SCORE), disease activity measurements, and the presence of carotid plaques by ultrasonography we

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Hernandez Camba, A., M. Carrillo-Palau, L. Ramos, et al. "P247 Carotid Plaque Assessment reclassifies patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S289. http://dx.doi.org/10.1093/ecco-jcc/jjab076.373.

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Abstract Background The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD) into the very high-CV-risk category and whether this may be related to disease features. Methods Multicenter cross-sectional study encompassing 186 IBD patients and 175 controls. Systematic Coronary Risk Evaluation (SCORE), disease activity measurements, and the presence of carot

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Ahmad, Ridha. "Reclassification of Traditional and Modern Dayah in Aceh from The Perspective of Systems Theory." Journal of Society Innovation and Development (JSID) 2, no. 2 (2020): https://journal.institutre.org/index.php/jsid. https://doi.org/10.5281/zenodo.8355820.

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Dayah is an Islamic educational institution that has developed in Aceh since the time of the entry of Islam in Samudera Pasai. This institution has contributed a lot to the development of Aceh until now, but this development occurs during the modernization period, it does not rule out the possibility that this change will make a modernbased dayah curriculum systematic according to the situation and conditions of the times, thus several Islamic education institutions that are almost similar to dayah in the characteristics of identity. This change does not make that all dayah in Aceh will change

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Holewijn, Suzanne, Martin den Heijer, Lambertus A. Kiemeney, Anton F. H. Stalenhoef, and Jacqueline de Graaf. "Combining risk markers improves cardiovascular risk prediction in women." Clinical Science 126, no. 2 (2013): 139–46. http://dx.doi.org/10.1042/cs20130178.

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Cardiovascular risk stratification could be improved by adding measures of atherosclerosis to current risk scores, especially in intermediate-risk individuals. We prospectively evaluated the additive value of different non-invasive risk markers (both individual and combined) for gender-specific cardiovascular risk stratification on top of traditional risk factors in a middle-aged population-based cohort. Carotid-plaques, IMT (intima–media thickness), ABI (ankle–brachial index), PWV (pulse–wave velocity), AIx (augmentation index), CAP (central augmented pressure) and CSP (central-systolic press

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Zhang, Zhibin, Yongfeng Huang, and Hongchao Liu. "On the Reclassification of Short GRBs." Proceedings of the International Astronomical Union 8, S290 (2012): 361–63. http://dx.doi.org/10.1017/s1743921312020418.

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AbstractBy collecting 17 short gamma-ray bursts with necessary data, we find a correlation of Lp ∝ Ep,i1.7, which is very consistent with that derived from a greatly expanded sample of 148 Swift long gamma-ray bursts. It is argued that the radiation mechanism of both long and short gamma-ray bursts should be similar, i.e., of quasi-thermal origin caused by the photosphere and the dissipation occurring very near the central engine. In addition, we suggest that the Ep,i-Lp relation can be used to identified a burst among normal short bursts, short bursts with extended emission and long bursts wi

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Simões, Roseli França, André Barretto Bruno Wilke, Carolina Romeiro Fernandes Chagas, et al. "Wing Geometric Morphometrics as a Tool for the Identification of Culex Subgenus Mosquitoes of Culex (Diptera: Culicidae)." Insects 11, no. 9 (2020): 567. http://dx.doi.org/10.3390/insects11090567.

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Culex is the largest subgenus within the genus Culex that includes important vectors of diseases. The correct identification of mosquitoes is critical for effective control strategies. Wing geometric morphometrics (WGM) has been used to identify mosquito species alongside traditional identification methods. Here, WGM was used for eleven Culex species from São Paulo, Brazil, and one from Esquel, Argentina. Adult mosquitoes were collected using CDC (Centers for Disease Control) traps, morphologically identified and analyzed by WGM. The canonical variate analysis (CVA) was performed and a Neighbo

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Qin, Tao, Guanning Wei, Haiping Zhao, Yong Li, Hengxing Ba, and Chunyi Li. "Reclassification of velvet antler portions following transcriptomic analysis." Animal Production Science 60, no. 10 (2020): 1364. http://dx.doi.org/10.1071/an19482.

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Context Commercially, velvet antlers along the longitudinal axis are divided into four portions, namely, wax-like (WL), blood-colour (BC), honeycomb-like (HL) and bone (B) slices from the top to the base. However, there is no evidence at a molecular level showing the accuracy of this classification. Aims The aim of the present study was to take transcriptional approach to assess the accuracy of the traditional classification for these four portions of velvet antler, and to link the expressed mRNAs of each portion with possible functions by using bioinformatics analysis. Methods Three sticks of

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Paul, Paulin, Noel George, and B. Priestly Shan. "Relative Estimate of Revised Cardiovascular Risk Combining Traditional and Non-traditional Image-based CV Markers: A Kerala Based Study." Current Medical Imaging Formerly Current Medical Imaging Reviews 16, no. 9 (2020): 1131–53. http://dx.doi.org/10.2174/1573405616666200218125539.

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Background: Non-traditional image markers can improve the traditional cardiovascular risk estimation, is untested in Kerala based participants. Objective: To identify the relationship between the ‘Modified CV risk’ categories with traditional and non-traditional image-based risk markers. The correlation and improvement in reclassification, achieved by pooling atherosclerotic non-traditional markers with Intermediate (≥7.5% and <20%) and High (≥20%) 10-year participants is evaluated. Methods: The cross-sectional study with 594 participants has the ultrasound measurements recorded from the me

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Jordal, Bjarte, Sarah Smith, and Anthony Cognato. "Classification of weevils as a data-driven science: leaving opinion behind." ZooKeys 439 (September 8, 2014): 1–18. https://doi.org/10.3897/zookeys.439.8391.

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Data and explicit taxonomic ranking criteria, which minimize taxonomic change, provide a scientific approach to modern taxonomy and classification. However, traditional practices of opinion-based taxonomy (i.e., mid-20th century evolutionary systematics), which lack explicit ranking and naming criteria, are still in practice despite phylogenetic evidence. This paper discusses a recent proposed reclassification of weevils that elevates bark and ambrosia beetles (Scolytinae and Platypodinae) to the ranks of Family. We demonstrate that the proposed reclassification 1) is not supported by an evolu

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Shropshire, Sandra, Jenny Lynne Semenza, and Karen Kearns. "Promotion and tenure: Carnegie reclassification triggers a revision." Library Management 36, no. 4/5 (2015): 340–50. http://dx.doi.org/10.1108/lm-09-2014-0113.

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Purpose – The purpose of this paper is to provide a comprehensive assessment of promotion and tenure for librarians in light of increased scrutiny and expectations by the administration of Idaho State University (ISU). This increased rigour was prompted by a move up in the Carnegie Classification System. Design/methodology/approach – A literature review was performed using library databases, as well as assessing peer institution promotion and tenure documents. Additionally ongoing feedback from University administrators was solicited. The process took for the creation of a new promotion and te

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Ahmad Ridha. "Reclassification of Traditional and Modern Dayah in Aceh from The Perspective of Systems Theory." Journal of Society Innovation and Development 2, no. 1 (2020): 39–49. https://doi.org/10.63924/jsid.v2i1.17.

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Dayah is an Islamic educational institution that has developed in Aceh since the time of the entry of Islam in Samudera Pasai. This institution has contributed a lot to the development of Aceh until now, but this development occurs during the modernization period, it does not rule out the possibility that this change will make a modern-based dayah curriculum systematic according to the situation and conditions of the times, thus several Islamic education institutions that are almost similar to dayah in the characteristics of identity. This change does not make that all dayah in Aceh will chang

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Searing, Elizabeth A. M. "Life, Death, and Zombies: Revisiting Traditional Concepts of Nonprofit Demise." Journal of Public and Nonprofit Affairs 6, no. 3 (2020): 354–76. http://dx.doi.org/10.20899/jpna.6.3.354-376.

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There is a robust literature examining financial vulnerability and demise of nonprofit organizations, particularly in the United States. However, much of this knowledge stems from inconsistent definitions of nonprofit demise. Using eight comparative case studies, this study revisits traditional definitions of nonprofit life and death to better reflect actual organizational operating status. Following this reclassification, findings from this study show that certain internal and external characteristics are more important in determining a nonprofit’s operational status. In particular, nonprofit

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Spitzer, A. Robert. "Reclassification of clinical sleep disorders using traditional models of syndromic, neuroanatomic, pathophysiological and etiological diagnosis." Medical Hypotheses 83, no. 3 (2014): 391–97. http://dx.doi.org/10.1016/j.mehy.2014.06.019.

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Palmou-Fontana, Natalia, David Martínez-Lopez, Alfonso Corrales, et al. "Disease Activity Influences Cardiovascular Risk Reclassification Based on Carotid Ultrasound in Patients with Psoriatic Arthritis." Journal of Rheumatology 47, no. 9 (2019): 1344–53. http://dx.doi.org/10.3899/jrheum.190729.

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Objective.Because the addition of carotid ultrasound (US) into composite cardiovascular (CV) risk scores has been found effective for identifying patients with inflammatory arthritis and high CV risk, we aimed to determine whether its use would facilitate the reclassification of patients with psoriatic arthritis (PsA) into the very high Systematic Coronary Risk Evaluation (SCORE) risk category and whether this might be related to disease features.Methods.This was a cross-sectional study involving 206 patients who fulfilled ClASsification for Psoriatic ARthritis criteria for PsA, and 179 contro

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Lin, Boliang, Xingkui Li, Zexi Zhang, and Yinan Zhao. "Optimizing Transport Scheme of High Value-Added Shipments in Regions without Express Train Services." Sustainability 11, no. 21 (2019): 6108. http://dx.doi.org/10.3390/su11216108.

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In railway transportation, high value-added shipments in regions with large traffic volumes are generally delivered by express train services, since these freights need to be delivered in a short time. However, there are also high value-added shipments in areas where express train services are not available. If these freights are delivered by the traditional approaches (i.e., the freight cars are delivered to the adjacent classification yard by local trains, combined with other freight cars to form a train, and finally sent to the destination according to the transportation plan) with multiple

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Aryan, Zahra, Alireza Ghajar, Sara Faghihi-Kashani, Mohsen Afarideh, Manouchehr Nakhjavani, and Alireza Esteghamati. "Baseline High-Sensitivity C-Reactive Protein Predicts Macrovascular and Microvascular Complications of Type 2 Diabetes: A Population-Based Study." Annals of Nutrition and Metabolism 72, no. 4 (2018): 287–95. http://dx.doi.org/10.1159/000488537.

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Background/Aims: This prospective study is aimed at examining the predictive value of high-sensitivity C-reactive protein (hs-CRP) for coronary heart disease (CHD) events and microvascular complications of type 2 diabetes mellitus (T2DM). Methods: A population-based study (NCT02958579) was conducted on 1,301 participants with T2DM (mean follow-up of 7.5 years). Risk assessment for vascular events was done at baseline, and serum hs-CRP was measured. End points of this study include CHD events, diabetic retinopathy, neuropathy, and diabetic kidney disease. Individuals with unavailable data or hs

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Wang, Guizhou, Jianbo Liu, and Guojin He. "A Method of Spatial Mapping and Reclassification for High-Spatial-Resolution Remote Sensing Image Classification." Scientific World Journal 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/192982.

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This paper presents a new classification method for high-spatial-resolution remote sensing images based on a strategic mechanism of spatial mapping and reclassification. The proposed method includes four steps. First, the multispectral image is classified by a traditional pixel-based classification method (support vector machine). Second, the panchromatic image is subdivided by watershed segmentation. Third, the pixel-based multispectral image classification result is mapped to the panchromatic segmentation result based on a spatial mapping mechanism and the area dominant principle. During the

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Zhong, Chongke, Zhengbao Zhu, Aili Wang, et al. "Multiple biomarkers covering distinct pathways for predicting outcomes after ischemic stroke." Neurology 92, no. 4 (2018): e295-e304. http://dx.doi.org/10.1212/wnl.0000000000006717.

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ObjectiveTo study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke.MethodsWe derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after ischemic stroke, and secondary outcomes included major disability, death, and vascular events.ResultsIn 3,405 participants, 866 participants (25.4%) experienced major disability or died within 3 months. In multivariable analyses, eleva

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Sumruayphol, Suchada, Praphaiphat Siribat, Jean-Pierre Dujardin, Sébastien Dujardin, Chalit Komalamisra, and Urusa Thaenkham. "Fasciola gigantica, F. hepatica and Fasciola intermediate forms: geometric morphometrics and an artificial neural network to help morphological identification." PeerJ 8 (February 18, 2020): e8597. http://dx.doi.org/10.7717/peerj.8597.

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Background Fasciola hepatica and F. gigantica cause fascioliasis in both humans and livestock. Some adult specimens of Fasciola sp. referred to as “intermediate forms” based on their genetic traits, are also frequently reported. Simple morphological criteria are unreliable for their specific identification. In previous studies, promising phenotypic identification scores were obtained using morphometrics based on linear measurements (distances, angles, curves) between anatomical features. Such an approach is commonly termed “traditional” morphometrics, as opposed to “modern” morphometrics, whic

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Pezel, Theo, Bharath Ambale Venkatesh, Henrique Doria De Vasconcellos, et al. "Left Atrioventricular Coupling Index as a Prognostic Marker of Cardiovascular Events: The MESA Study." Hypertension 78, no. 3 (2021): 661–71. http://dx.doi.org/10.1161/hypertensionaha.121.17339.

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Both left atrial and left ventricular functional parameters influence the prognosis of patients with cardiovascular diseases. This study aimed to investigate the prognostic value of a novel left atrioventricular coupling index (LACI) in a population without history of cardiovascular diseases at baseline. Participants of the Multi-Ethnic Study of Atherosclerosis who underwent a baseline cardiovascular magnetic resonance study were analyzed. LACI was defined by the ratio of the left atrial end-diastolic volume divided by the left ventricular end-diastolic volume. Cox proportional hazard models w

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Elias-Smale, Suzette E., Maryam Kavousi, Germaine C. Verwoert, et al. "Common carotid intima-media thickness in cardiovascular risk stratification of older people: the Rotterdam Study." European Journal of Preventive Cardiology 19, no. 4 (2011): 698–705. http://dx.doi.org/10.1177/1741826711414623.

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Aim: Non-invasive measures of atherosclerosis, such as carotid intima-media thickness (cIMT), may improve global cardiovascular risk prediction. The aim of this study was to determine whether common carotid IMT in addition to traditional risk factors improves risk classification in a general population of older people. Methods and results: A group of 3580 non-diabetic people aged 55–75 years and free of cardiovascular disease at baseline were followed for a median time of 12.2 years. Compared to models based on Framingham risk factors, we studied the ability of common cIMT measurement to bette

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Vassallo, Diana, Helen Alderson, Nicolas Vuilleumier, et al. "Association of novel biomarkers with major clinical outcomes in a cohort of patients with atherosclerotic renovascular disease." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 56, no. 4 (2019): 488–501. http://dx.doi.org/10.1177/0004563219850850.

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Introduction In this study, we investigate whether the addition of biomarkers to a model based on traditional risk factors improves risk prediction and patient selection for revascularization in atherosclerotic renovascular disease. Methods Patients in the Salford Renovascular Study who had the following biomarkers analysed on a baseline sample were included in this study: FGF-23, Cystatin C, kidney injury molecule-1, myeloperoxidase, neutrophil gelatinase-associated lipocalin, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity Troponin T and anti-apolipoprotein A

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Ethamsetti, Ganeswar Rao. "Driving Innovation in ERP Finance with Master Data Automation: Verizon’s SAP 1ERP Legal Entity Rationalization." European Journal of Computer Science and Information Technology 13, no. 48 (2025): 154–63. https://doi.org/10.37745/ejcsit.2013/vol13n48154163.

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This article examines Verizon's innovative approach to organizational restructuring through its SAP 1ERP Legal Entity Rationalization project. To analyze how a rule-based automation framework was developed to dynamically apply new master data during financial posting processes, thereby eliminating the need for traditional manual reclassification of accounting entries. Traditional approaches to legal entity rationalization are typically labor-intensive, error-prone, and create delays in financial reporting and consolidation activities. Verizon's architectural solution leveraged SAP's native sub

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Mahajan, Hemant, Maryam Zaid, Rachel Mackey, et al. "Lipoprotein particles and coronary artery calcium in middle-aged US-White and Japanese men." Open Heart 6, no. 2 (2019): e001119. http://dx.doi.org/10.1136/openhrt-2019-001119.

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ObjectiveThis cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese).MethodsIn a population-based study of 570 randomly selected asymptomatic men aged 40–49 years (270 US-White and 300 Japanese), we examined the relationship between race/ethnicity, NMR-measured lipoproteins and CAC (measure

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Alashi, Alaa, Richard Lang, Raul Seballos, et al. "Reclassification of coronary heart disease risk in a primary prevention setting: traditional risk factor assessment vs. coronary artery calcium scoring." Cardiovascular Diagnosis and Therapy 9, no. 3 (2019): 214–20. http://dx.doi.org/10.21037/cdt.2019.04.05.

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Powell, Gareth S., Andrew R. Cline, Alexandra G. Duffy, and Jennifer M. Zaspel. "Phylogeny and reclassification of Carpophilinae (Coleoptera: Nitidulidae), with insights into the origins of anthophily." Zoological Journal of the Linnean Society 189, no. 4 (2020): 1359–69. http://dx.doi.org/10.1093/zoolinnean/zlaa001.

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Abstract The family Nitidulidae is known for its diverse life histories, with some species considered economically detrimental pests, while others perform critical ecosystem functions. Despite this, their evolutionary relationships still lack support and understanding. A robust phylogenetic hypothesis and revised taxonomic classification for this group, particularly the subfamily Carpophilinae, could help delineate key lineages for assessing the evolution of both beneficial and pestiferous traits. The most complete molecular phylogeny of Carpophilinae to date, based on 37 ingroup taxa, coverin

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Khan, Sadiya S., Wendy S. Post, Xiuqing Guo, et al. "Coronary Artery Calcium Score and Polygenic Risk Score for the Prediction of Coronary Heart Disease Events." JAMA 329, no. 20 (2023): 1768. http://dx.doi.org/10.1001/jama.2023.7575.

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ImportanceCoronary artery calcium score and polygenic risk score have each separately been proposed as novel markers to identify risk of coronary heart disease (CHD), but no prior studies have directly compared these markers in the same cohorts.ObjectiveTo evaluate change in CHD risk prediction when a coronary artery calcium score, a polygenic risk score, or both are added to a traditional risk factor–based model.Design, Setting, and ParticipantsTwo observational population-based studies involving individuals aged 45 years through 79 years of European ancestry and free of clinical CHD at basel

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T K, Mumthas, Lijiya A, and V. K. Govindan. "Karyotyping of Human Chromosomes Using M_FISH Images." INTERNATIONAL JOURNAL OF MANAGEMENT & INFORMATION TECHNOLOGY 4, no. 2 (2013): 248–56. http://dx.doi.org/10.24297/ijmit.v4i2.4621.

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Karyotyping is a technique used to align the chromosomes in the decreasing order of size so that the structural and numerical changes can be easily identified. Traditional chromosome analysis is simplified by the introduction of M_FISH (multiplex fluorescence in-situ hy-bridization), a combinatorial labeling technique in which each chromosomes appears in distinct color. In this paper, Bayes classification of M-FISH chromosome images using the features intensity in five channel as well as size of the chromosome is presented. Watershed transform is employed for segmentation . Also reclassificati

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Tang, Wendong, Xiaxian Shen, Hailing Li, et al. "The independent and incremental value of ultrasound carotid plaque length to predict the presence and severity of coronary artery disease: analysis from the carotid plaque length prospective registry." European Heart Journal - Cardiovascular Imaging 21, no. 4 (2019): 389–96. http://dx.doi.org/10.1093/ehjci/jez304.

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Abstract Aims Data regarding the relationship between carotid plaque length (CPL) and coronary artery disease (CAD) are lacking. This study aimed to assess the predictive value of CPL for the severity of CAD. Methods and results We prospectively enrolled 2149 consecutive patients who underwent both first coronary angiography and carotid ultrasonography with measurements of intima-media thickness (IMT), plaque score (PS), and CPL. In total, 1408 (65.5%) patients had CAD (defined as stenosis ≥50%), and 741 (34.5%) patients had no CAD. Patients with CAD had longer maximal CPL than those without C

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Cook, Nancy R. "Statistical Evaluation of Prognostic versus Diagnostic Models: Beyond the ROC Curve." Clinical Chemistry 54, no. 1 (2008): 17–23. http://dx.doi.org/10.1373/clinchem.2007.096529.

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Abstract Background: Diagnostic and prognostic or predictive models serve different purposes. Whereas diagnostic models are usually used for classification, prognostic models incorporate the dimension of time, adding a stochastic element. Content: The ROC curve is typically used to evaluate clinical utility for both diagnostic and prognostic models. This curve assesses how well a test or model discriminates, or separates individuals into two classes, such as diseased and nondiseased. A strong risk predictor, such as lipids for cardiovascular disease, may have limited impact on the area under t

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Zakharova, Galina, Victor Efimov, Mikhail Raevskiy, et al. "Reclassification of TCGA Diffuse Glioma Profiles Linked to Transcriptomic, Epigenetic, Genomic and Clinical Data, According to the 2021 WHO CNS Tumor Classification." International Journal of Molecular Sciences 24, no. 1 (2022): 157. http://dx.doi.org/10.3390/ijms24010157.

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In 2021, the fifth edition of the WHO classification of tumors of the central nervous system (WHO CNS5) was published. Molecular features of tumors were directly incorporated into the diagnostic decision tree, thus affecting both the typing and staging of the tumor. It has changed the traditional approach, based solely on histopathological classification. The Cancer Genome Atlas project (TCGA) is one of the main sources of molecular information about gliomas, including clinically annotated transcriptomic and genomic profiles. Although TCGA itself has played a pivotal role in developing the WHO

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Kebaier Ep Chaabouni, Narda, Katherine Vroobel, Ayoma Attygalle, et al. "Risk reclassification of endometrial cancer according to molecular profiling: UK single centre experience." Journal of Clinical Oncology 41, no. 16_suppl (2023): e17628-e17628. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e17628.

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e17628 Background: Endometrial cancer (EC) ranks second among gynaecological malignancies worldwide. Traditionally, adjuvant treatment recommendation was based on risk stratification based on clinicopathological data. The Cancer Genome Atlas (TCGA) defined four distinct and prognostically significant molecular subgroups. Recent international guidelines recommend integrating molecular classification into risk stratification. The aim of our study was to evaluate the distribution of molecular groups in our population and its impact on treatment decision. Methods: Retrospective cohort study includ

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Peiró, Óscar M., Nuria Farré, German Cediel, et al. "Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome." Biomarkers in Medicine 13, no. 14 (2019): 1187–98. http://dx.doi.org/10.2217/bmm-2019-0133.

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Aim: To explore long-term prognostic value of SDF-1 in acute coronary syndrome (ACS). Materials & methods: We included 254 patients with ACS. Plasma SDF-1 was measured and patients were classified into tertiles of SDF-1. Results: Multivariate analysis showed third tertile of SDF-1 as an independent predictor of all-cause death (HR: 2.5; 95% CI: 1.2–5.2; p = 0.011) and the composite of major adverse cardiovascular and cerebrovascular events (HR: 1.8; 95% CI: 1.1–3.1; p = 0.031). SDF-1 added to a clinical model can improve all-cause death prediction (net reclassification improvement 0.362; 9

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Xu, Yu, Mian Li, Guijun Qin, et al. "Cardiovascular Risk Based on ASCVD and KDIGO Categories in Chinese Adults: A Nationwide, Population-Based, Prospective Cohort Study." Journal of the American Society of Nephrology 32, no. 4 (2021): 927–37. http://dx.doi.org/10.1681/asn.2020060856.

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BackgroundThe Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guideline used eGFR and urinary albumin-creatinine ratio (ACR) to categorize risks for CKD prognosis. The utility of KDIGO’s stratification of major CVD risks and predictive ability beyond traditional CVD risk prediction scores are unknown.MethodsTo evaluate CVD risks on the basis of ACR and eGFR (individually, together, and in combination using the KDIGO risk categories) and with the atherosclerotic cardiovascular disease (ASCVD) score, we studied 115,366 participants in the China Cardiometabolic Disease and Canc

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Bundy, Joshua D., Mahboob Rahman, Kunihiro Matsushita, et al. "Risk Prediction Models for Atherosclerotic Cardiovascular Disease in Patients with Chronic Kidney Disease: The CRIC Study." Journal of the American Society of Nephrology 33, no. 3 (2022): 601–11. http://dx.doi.org/10.1681/asn.2021060747.

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BackgroundIndividuals with CKD may be at high risk for atherosclerotic cardiovascular disease (ASCVD). However, there are no ASCVD risk prediction models developed in CKD populations to inform clinical care and prevention.MethodsWe developed and validated 10-year ASCVD risk prediction models in patients with CKD that included participants without self-reported cardiovascular disease from the Chronic Renal Insufficiency Cohort (CRIC) study. ASCVD was defined as the first occurrence of adjudicated fatal and nonfatal stroke or myocardial infarction. Our models used clinically available variables

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McHenry, Scott, Ankita Tirath, Richard Tsai, et al. "Derivation and Internal Validation of a Clinical Prediction Tool to Predict Nonalcoholic Fatty Liver Disease in Patients With Crohn’s Disease." Inflammatory Bowel Diseases 26, no. 12 (2020): 1917–25. http://dx.doi.org/10.1093/ibd/izz324.

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Abstract Background Crohn’s disease (CD) patients have more than double the risk of nonalcoholic fatty liver disease (NAFLD) compared with the general population after considering traditional risk factors. NAFLD remains underappreciated because routine imaging and liver biochemistries are neither sensitive nor specific for the diagnosis. Here we developed a Clinical Prediction Tool for NAFLD in CD (CPN-CD) using readily accessible parameters to diagnose NAFLD, as determined by magnetic resonance proton density fat fraction (PDFF). Methods A total of 311 consecutive CD patients who underwent ma

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Chen, Yiheng, Jinbai Zou, Lihai Liu, and Chuanbo Hu. "Improved Oversampling Algorithm for Imbalanced Data Based on K-Nearest Neighbor and Interpolation Process Optimization." Symmetry 16, no. 3 (2024): 273. http://dx.doi.org/10.3390/sym16030273.

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The problems of imbalanced datasets are generally considered asymmetric issues. In asymmetric problems, artificial intelligence models may exhibit different biases or preferences when dealing with different classes. In the process of addressing class imbalance learning problems, the classification model will pay too much attention to the majority class samples and cannot guarantee the classification performance of the minority class samples, which might be more valuable. By synthesizing the minority class samples and changing the data distribution, unbalanced datasets can be optimized. Traditi

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Guo, Meiying, Xindong Sun, Jinming Yu, and Linlin Wang. "Immunoscore classifier:A gene based prognostic tool in early non-small cell lung cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21030-e21030. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21030.

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e21030 Background: The clinical benefits of immunotherapy in patients with stage I non-small cell lung cancer (NSCLC) is still controversial. Immune status plays critical role in the development and progression of NSCLC, and is associated with the patient survival outcomes. The analysis of immune features is thus valuable for the determination of immunotherapy. However, one single immune feature cannot reflect the complex immune status, and its prognostic value is extremely limited. In this study, we aimed to construct an immunoscore classifier based on multiple immuno-genes to predict the pro

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Camps-Vilaro, Anna, Isaac Subirana, Rafel Ramos, et al. "Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study." International Journal of Molecular Sciences 24, no. 9 (2023): 7934. http://dx.doi.org/10.3390/ijms24097934.

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Ischemic cardiovascular diseases (CVD) originate from an imbalance between atherosclerotic plaque formation, instability, and endothelial healing dynamics. Our aim was to examine the relationship between 5-year changes in inflammatory, metabolic, and oxidative biomarkers and 10-year CVD incidence in a population without previous CVD. This was a prospective cohort study of individuals aged 35–74 years (n = 419) randomly selected from 5263 REGICOR participants without CVD recruited in 2005. Biomarkers were measured at baseline and in 2010. Participants were followed up until 2020 for a composite

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Kim, Soohyun, Byung-Hee Hwang, Kwan Yong Lee, et al. "High Uric Acid Levels in Acute Myocardial Infarction Provide Better Long-Term Prognosis Predictive Power When Combined with Traditional Risk Factors." Journal of Clinical Medicine 11, no. 19 (2022): 5531. http://dx.doi.org/10.3390/jcm11195531.

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The current study aimed to investigate the association between serum UA levels and the mortality rate of AMI patients. We analyzed 5888 patients with successfully revascularized AMI (mean age: 64.0 ± 12.7 years). The subjects were divided into the high UA group (uric acid >6.5 mg/dL for males, >5.8 mg/dL for females) or the normal UA group based on initial serum UA level measured at admission. The primary outcome was all-cause mortality. A total of 4141 (70.3%) and 1747 (29.7%) patients were classified into the normal UA group and high UA groups, respectively. Over a median follow-up of

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Gatto, Laura, and Francesco Prati. "Subclinical atherosclerosis: how and when to treat it?" European Heart Journal Supplements 22, Supplement_E (2020): E87—E90. http://dx.doi.org/10.1093/eurheartj/suaa068.

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Abstract Atherosclerosis is a condition characterized by a long, initial, asymptomatic phase. Progression of disease could lead to acute coronary events, such as acute myocardial infarction, unstable angina, or sudden cardiac death. However, there are imaging techniques, namely vascular echography and assessment of coronary calcium, capable to make the diagnosis of atherosclerosis at an early stage. There are several studies demonstrating the ability of statins to delay, and in some situation even revert the progression of this condition. Subclinical atherosclerosis is highly prevalent in peop

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Abbasi, Ali, Lyanne M. Kieneker, Eva Corpeleijn, et al. "Plasma N-terminal Prosomatostatin and Risk of Incident Cardiovascular Disease and All-Cause Mortality in a Prospective Observational Cohort: the PREVEND Study." Clinical Chemistry 63, no. 1 (2017): 278–87. http://dx.doi.org/10.1373/clinchem.2016.259275.

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Abstract BACKGROUND Somatostatin is a component of the well-known insulin-like growth factor-1/growth hormone (GH) longevity axis. There is observational evidence that increased GH is associated with an increased risk of cardiovascular disease (CVD). We aimed to investigate the potential association of plasma N-terminal fragment prosomatostatin (NT-proSST) with incident CVD and all-cause mortality in apparently healthy adults. METHODS We studied 8134 participants without history of CVD (aged 28–75 years; women, 52.6%) from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study

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Zalawadiya, Sandip K., Sidakpal S. Panaich, Vikas Veeranna, Ashutosh Neeraj, Naga V. Kommuri, and Luis Afonso. "Abstract 16797: Red Cell Distribution Width and Risk of Coronary Heart Disease Among Low Risk Healthy Representative US Adults." Circulation 124, suppl_21 (2011). http://dx.doi.org/10.1161/circ.124.suppl_21.a16797.

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Objective: Evaluate the risk reclassification properties of red cell distribution width (RDW) in low risk healthy population free of prior cardiovascular disease (CVD) and diabetes. Background: Red cell distribution width (RDW) is an independent predictor of future CVD events. No prior study has evaluated whether addition of RDW to traditional cardiovascular risk factors (CVRF) (age, male sex, hypertension, dyslipidemia and smoking) improves risk reclassification, especially for those at intermediate risk of CVD events. Study Type: Prospective observational Methods: 15,460 participants aged ≥2

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Cook, Nancy R., and Paul M. Ridker. "Abstract 3124: The Magnitude of Reclassification Indices for Individual Predictors of Global Cardiovascular Risk." Circulation 118, suppl_18 (2008). http://dx.doi.org/10.1161/circ.118.suppl_18.s_1097.

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Methods based on risk stratification have recently been proposed to evaluate and compare predictive risk models, but their performance in clinically relevant populations has not been demonstrated, including for well-known cardiovascular risk predictors. We fit models including traditional risk factors as well as high-sensitivity C-reactive protein (hsCRP) and parental history of myocardial infarction in prospective data from 24,558 women in the Women’s Health Study who experienced 766 cardiovascular events over an average 10-year follow-up. Fit of models with and without each risk factor was e

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Florie, Naomi H. M., Rob Eerdekens, Maria V. Manzi, et al. "Potential effects of the hydrostatic pressure gradient on hyperemic and non-hyperemic pressure ratios." American Journal of Physiology-Heart and Circulatory Physiology, July 21, 2023. http://dx.doi.org/10.1152/ajpheart.00305.2023.

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Background When measuring hyperemic and non-hyperemic pressure ratios with traditional sensor-tipped wires, the inevitable hydrostatic pressure gradient (HPG) may influence treatment decisions. This study aimed to simulate and analyse the effect of a hydrostatic pressure gradient on different indices of functional lesion severity. Methods A hypothetical Pd-Pa height difference and subsequent hydrostatic pressure gradient based on previous literature was applied to the pressure measurements from the CONTRAST study. The effect on three indices of functional lesion severity (FFR, Pd/Pa, and dPR)

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Fansler, Samuel D., Kelly M. Bakulski, Sung Kyun Park, Erika Walker, and Xin Wang. "Use of biomarkers of metals to improve prediction performance of cardiovascular disease mortality." Environmental Health 23, no. 1 (2024). http://dx.doi.org/10.1186/s12940-024-01137-4.

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Abstract Background Whether including additional environmental risk factors improves cardiovascular disease (CVD) prediction is unclear. We attempted to improve CVD mortality prediction performance beyond traditional CVD risk factors by additionally using metals measured in the urine and blood and with statistical machine learning methods. Methods Our sample included 7,085 U.S. adults aged 40 years or older from the National Health and Nutrition Examination Survey 2003–2004 through 2015–2016, linked with the National Death Index through December 31, 2019. Data were randomly split into a 50/50

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Bie, Lizhan, Jingya Niu, Shujing Wu, et al. "Negative Risk Markers for Cardiovascular Risk Evaluation in Chinese Adults." Frontiers in Cardiovascular Medicine 9 (March 15, 2022). http://dx.doi.org/10.3389/fcvm.2022.800671.

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BackgroundThe atherosclerotic cardiovascular disease (ASCVD) risk predicted by traditional risk factors is used to guide preventive treatment. We aimed to investigate whether preferable levels of non-traditional emerging risk factors (i.e., negative risk markers) could downgrade the predicted ASCVD risk beyond traditional risk factors.MethodsA total of 7,568 Chinese adults aged ≥ 40 years were followed up during 2010–2015. Negative risk markers including non-traditional lipids, urinary albumin-to-creatinine ratio, electrocardiogram (ECG), and measurements of atherosclerosis were evaluated usin

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Caldinelli, Aurora, Anne-Laure Faucon, Arvid Sjölander, et al. "Risk-based referral model to nephrologist-specialist care in Stockholm." Nephrology Dialysis Transplantation, July 9, 2025. https://doi.org/10.1093/ndt/gfaf128.

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Abstract Background and Hypothesis For most patients, clinical management of early stages of CKD is performed in primary care settings. KDIGO 2024 guidelines recommended using a 5-year kidney failure risk equation (KFRE) of 3–5% to guide nephrologist referrals. Here, we aimed to assess the impact of adopting a risk-based referral model compared to traditional referral criteria. Methods Observational retrospective study of adults with eGFR &lt; 60 mL/min/1.73m² (Lund-Malmö equation) from the SCREAM project, a healthcare utilization cohort from Stockholm, Sweden. We evaluated the performance

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Wahrenberg, Agnes, Ralf Kuja‐Halkola, Patrik K. E. Magnusson, et al. "Cardiovascular Family History Increases the Risk of Disease Recurrence After a First Myocardial Infarction." Journal of the American Heart Association 10, no. 23 (2021). http://dx.doi.org/10.1161/jaha.121.022264.

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Background Family history of atherosclerotic cardiovascular disease (ASCVD) is easily accessible and captures genetic cardiovascular risk, but its prognostic value in secondary prevention is unknown. Methods and Results We followed 25 615 patients registered in SWEDEHEART (Swedish Web‐System for Enhancement and Development of Evidence‐Based Care in Heart Disease Evaluated According to Recommended Therapies) from their 1‐year revisit after a first‐time myocardial infarction during 2005 to 2013, until December 31, 2018. Data on relatives, diagnoses and socioeconomics were extracted from national

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