Relevant bibliographies by topics / Recombinant human antibodies

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Recombinant human antibodies'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Recombinant human antibodies"

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Fuchs, P., S. Dübel, F. Breitling, M. Braunagel, I. Klewinghaus, and M. Little. "Recombinant human monoclonal antibodies." Cell Biophysics 21, no. 1-3 (1992): 81–91. http://dx.doi.org/10.1007/bf02789480.

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Matthews, Ruth C., and James P. Burnie. "Human recombinant antibodies and immunotherapy." FEMS Immunology and Medical Microbiology 9, no. 1 (1994): 1–6. http://dx.doi.org/10.1111/j.1574-695x.1994.tb00466.x.

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DUAN, Tao, Xiao-Fang WANG, Shu-Yuan XIAO, Shu-Yan GU, and Mi-Fang LIANG. "Recombinant Human IgG antibodies against Human Cytomegalovirus." Biomedical and Environmental Sciences 21, no. 5 (2008): 372–80. http://dx.doi.org/10.1016/s0895-3988(08)60057-4.

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Mazov, A. V. ,. "GENERATION AND CHARACTERIZATION OF POLYCLONAL ANTIBODIES SPECIFIC TO HUMAN ESTROGEN RECEPTOR ERα". Biotechnologia Acta 17, № 3 (2024): 59–65. http://dx.doi.org/10.15407/biotech17.03.059.

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Aim. The purpose of the study was to generate and characterize anti-hERα polyclonal antibodies for elucidation of functional relationships between isoforms of estrogen receptor ERα and isoforms of ribosomal protein S6 kinase — S6K1. Methods. cDNA cloning. Expression of recombinant proteins in bacterial system. Affinity purification of His-tag fused recombinant proteins using Ni-NTA chromatography from bacterial lysates. Generation of polyclonal sera by mice immunization. Western blot analysis and immunoprecipitation. Results. cDNA coding for full length hERα was cloned into expression vector p
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GRIPPO, VANINA, LETICIA L. NIBORSKI, KARINA A. GOMEZ та MARIANO J. LEVIN. "Human recombinant antibodies againstTrypanosoma cruziribosomal P2βprotein". Parasitology 138, № 6 (2011): 736–47. http://dx.doi.org/10.1017/s0031182011000175.

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SUMMARYPatients with chronic Chagas' Heart Disease (cChHD) develop an antibody response that is suspected to be involved in the cardiac pathogenesis. The response againstTrypanosoma cruziribosomal P proteins is of particular interest, as these antibodies can cross-react with host cardiac receptors causing electrophysiological alterations. To better understand the humoral anti-P response we constructed a single-chain variable fragment library derived from a cChHD patient. The variable heavy and light regions were amplified from bone-marrow RNA and subcloned into the vector pComb3X. The phage li
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de Kruif, J., A.-R. van der Vuurst de Vries, L. Clienti, E. Boel, T. Logtenberg, and W. van Ewijk. "New perspectives on recombinant human antibodies." Immunology Today 17, no. 10 (1996): 453–55. http://dx.doi.org/10.1016/0167-5699(96)30057-y.

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Naranjo, Leslie, Fortunato Ferrara, Nicolas Blanchard, et al. "Recombinant Antibodies against Mycolactone." Toxins 11, no. 6 (2019): 346. http://dx.doi.org/10.3390/toxins11060346.

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In the past, it has proved challenging to generate antibodies against mycolactone, the primary lipidic toxin A of Mycobacterium ulcerans causing Buruli ulcer, due to its immunosuppressive properties. Here we show that in vitro display, comprising both phage and yeast display, can be used to select antibodies recognizing mycolactone from a large human naïve phage antibody library. Ten different antibodies were isolated, and hundreds more identified by next generation sequencing. These results indicate the value of in vitro display methods to generate antibodies against difficult antigenic targe
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PARIS, N., R. ROBERT, and L. MERCIER. "Monoclonal Antibodies Against Methionyl Recombinant Human Prolactin." Hybridoma 12, no. 1 (1993): 107–13. http://dx.doi.org/10.1089/hyb.1993.12.107.

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Maruyama, Toshiaki, Paul W. H. I. Parren, Anthony Sanchez, et al. "Recombinant Human Monoclonal Antibodies to Ebola Virus." Journal of Infectious Diseases 179, s1 (1999): S235—S239. http://dx.doi.org/10.1086/514280.

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Maruyama, Toshiaki, Paul W. H. I. Parren, Anthony Sanchez, et al. "Recombinant Human Monoclonal Antibodies to Ebola Virus." Journal of Infectious Diseases 179, s1 (1999): S235—S239. https://doi.org/10.5281/zenodo.13446571.

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Dissertations / Theses on the topic "Recombinant human antibodies"

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Davidson, Lisa. "Humanised recombinant antibodies for human cancer therapy." Thesis, University of Strathclyde, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501643.

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Humanisation of rodent mAbs by CDR-grafting is now a standard procedure for reducing immunogenicity and recruiting human effector functions with ten humanised mAbs approved for use and many more in development. This project aimed to develop two anti-cancer therapeutics aimed at exploiting two tumour associated antigens overexpressed in the tumour environment.
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Johansson, Daniel X. "Expression and interaction studies of recombinant human monoclonal antibodies /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-137-1/.

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Fiddes, Jane L. Sutton Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Development of recombinant human monoclonal antibodies suitable for blood grouping using antibody engineering techniques." Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2007. http://handle.unsw.edu.au/1959.4/40503.

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Transfusion medicine is an important part of modern health care and the provision of reliably phenotyped red blood cells (RBC) is essential for safe and effective blood transfusions. For identification of many RBC antigens, monoclonal antibodies of either murine or human origin are available for use in agglutination assays, in which they perform as well as or better than the human polyclonal antibody preparations which they have replaced. However, the detection of some blood groups is still reliant on the use of human polyclonal antisera, which is a less reliable reagent source with respect to
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Fuchs, Manon [Verfasser], and Stefan [Akademischer Betreuer] Dübel. "Human recombinant antibodies against Mycobacterium tuberculosis antigens / Manon Fuchs ; Betreuer: Stefan Dübel." Braunschweig : Technische Universität Braunschweig, 2014. http://d-nb.info/117582156X/34.

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Basu, B. J. "Development of human recombinant MT1-MMP antibodies for the diagnosis and treatment of cancer." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596458.

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MT1-MMP domains were expressed and purified as Calmodulin (CaM)-tagged recombinant proteins to serve as targets for identification of specific antibodies. V(ariable) domain phage display techniques were employed to isolate single chain V domain antibody fragments (scFvs) against MT1-MMP hemopexin domain from a naïve human V gene library. Following 3 rounds of phage selection using solid phase panning, unique antibody clones were identified that are specific for MT1-MMP and do not react with soluble MMPs. Sequencing of the V genes and epitope mapping studies by surface plasmon resonance identif
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Andersson, Eva. "Studies of T- and B-cells for the generation of human antigen specific antibodies." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945125.html.

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Marques, Fabiana Carvalho. "Development of specific recombinant single-domain antibodies against gp120 HIV-1 glycoprotein and their selection by Phage Display." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/16334.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections to succeed. One of the most important factors in the worldwide spread of HIV is its enormous genetic variability and rapid evolution. The revealing of all stages of HIV replication cycle led to the identification of potential therapeutic targets in order to decrease the replicative process. However, the acquisition and tra
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Raffai, Robert Leslie. "Immunochemical study of human apolipoprotein E: Development of LDL-receptor mimetic monoclonal antibodies, using recombinant DNA approaches." Thesis, University of Ottawa (Canada), 1998. http://hdl.handle.net/10393/4422.

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Apolipoprotein (apo)E is a 299 amino acid polypeptide that plays an important role in plasma lipoprotein metabolism. A major physiological function of apoE resides in its ability to be specifically recognized by cellular low-density-lipoprotein receptors (LDLr). A common apoE isoform is defective in its binding to the LDLr and its inheritance can lead to hyperlipidemia. In addition to apoE genetic polymorphism, apoE interaction with the LDLr also depends on apoE conformation. While lipid-free apoE cannot interact with the LDLr, upon binding to lipid, apoE undergoes a conformational change that
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Raffaï, Robert L. "Immunochemical study of human apolipoprotein E, development of LDL-receptor mimetic monoclonal antibodies, using recombinant DNA approaches." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ28369.pdf.

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Kenyon, Andrew Robert. "The directed selection of recombinant human anti-testosterone antibodies and their use in immuno-modulating androgen receptor function." Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493587.

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Prostate cancer (PCa) is the second most common cancer in Western men; with over 30,000 new cases are diagnosed in the UK each year. Primarily treatment involves targeting the androgen-signalling pathway by blocking production of testicular androgens and/or inhibiting AR function. Current treatments depend on the age and health of the patient. These treatments range from a watch and wait strategy to androgen ablation therapy, by chemical or surgical castration, with the addition of using anti-androgens to block the AR function. The drawbacks of these treatments include loss of bone mineral den
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Books on the topic "Recombinant human antibodies"

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Peter, Williamson. Characterisation of Bordetella pertussis antigens and production of human recombinant antibodies to these antigens. University of Manchester, 1996.

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Macdougall, Iain C. Erythropoiesis-stimulating agents in chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0124.

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The advent of recombinant human erythropoietin (epoetin) in the late 1980s transformed the management of renal anaemia, liberating many dialysis patients from lifelong regular blood transfusions, in turn causing severe iron overload and human leucocyte antigen sensitization. Epoetin can be administered either intravenously or subcutaneously, but the half-life of the drug is fairly short at around 6–8 hours, necessitating frequent injections. To circumvent this problem, two manipulations to the erythropoietin molecule were engineered. The first of these was to attach an extra two carbohydrate c
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Book chapters on the topic "Recombinant human antibodies"

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Larrick, J. W., and R. Balint. "Recombinant Therapeutic Human Monoclonal Antibodies." In The Pharmacology of Monoclonal Antibodies. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78432-3_2.

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Tomszak, Florian, Susanne Weber, Jonas Zantow, Thomas Schirrmann, Michael Hust, and André Frenzel. "Selection of Recombinant Human Antibodies." In Protein Targeting Compounds. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22473-2_3.

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Tomszak, Florian, Susanne Weber, Jonas Zantow, Thomas Schirrmann, Michael Hust, and André Frenzel. "Selection of Recombinant Human Antibodies." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32805-8_3.

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Chan, Soo Khim, Anizah Rahumatullah, Jing Yi Lai, and Theam Soon Lim. "Naïve Human Antibody Libraries for Infectious Diseases." In Recombinant Antibodies for Infectious Diseases. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-72077-7_3.

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Chan, Soo Khim, and Theam Soon Lim. "Immune Human Antibody Libraries for Infectious Diseases." In Recombinant Antibodies for Infectious Diseases. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-72077-7_4.

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Adams, Jarrett J., Bryce Nelson, and Sachdev S. Sidhu. "Recombinant Genetic Libraries and Human Monoclonal Antibodies." In Methods in Molecular Biology. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-586-6_9.

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Burton, Dennis R., and Carlos F. Barbas. "Human Antibodies to HIV-1 by Recombinant DNA Methods." In Chemical Immunology and Allergy. KARGER, 1993. http://dx.doi.org/10.1159/000319160.

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Hooker, Andrew D., Nicola H. Green, David C. James, et al. "Epitope Determination for Antibodies Raised Against Recombinant Human Interferon-Gamma." In Animal Cell Technology. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5404-8_43.

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Iatrou, Anastasia, Maria Fitopoulou, and Andreas Agathangelidis. "Generation and Reactivity Profiling of Functional Human Recombinant Monoclonal Antibodies." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4442-3_18.

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Greiner, John W., Fiorella Guadagni, Patricia Horan Hand, et al. "Augmentation of tumor antigen expression by recombinant human interferons: Enhanced targeting of monoclonal antibodies to carcinomas." In Cancer Imaging with Radiolabeled Antibodies. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-1497-4_21.

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Conference papers on the topic "Recombinant human antibodies"

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Gee, A. P. "Hematopoietic Stem Cell Engineering: The Magic Bullet of the Next Millenium?" In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1317.

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Abstract Hematopoietic stem cell [HSC] therapy has its origins as hematological rescue following marrow ablative high-dose therapy for refractory cancers and myelodysplastic syndromes. In its simplest form, bone marrow is collected from a tissue-matched related normal donor and intravenously infused into the patient who has usually received high-dose chemo/radiotherapy for his or her disease. The stem cells migrate to the marrow spaces, where they multiply and differentiate to restore blood cell-forming activity and immune defenses in the recipient Restrictions in the availability of tissue-ma
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Pancham, N., M. Dumas, M. S. Madant, P. C. Esmon, and V. Voehrinqer. "RECOMBINANT AND PLASMA FVIII SHARE EPITOPES RECOGNIZED BY A PANEL OF MONOCLONAL AND POLYCLONAL ANTIBODIES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644028.

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A panel of neutralizing and nonneutralizing monoclonal and polyclonal antibodies raised against human plasma FVIII and human recombinant FVIII was employed in Western blotting, activity inhibition and two-site ELISA studies to investigate structural similarities between recombinant FVIII (r-FVIII) and plasma FVIII (p-FVIII). The monoclonal antibodies were obtained either commercially or produced in-house and react with either the 90kd, 80kd or B-region polypeptides. Some antibodies were raised to FVIII synthetic peptides. Rabbit polyclonal antibodies were obtained from either r-FVIII or p-FVII
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Pancham, N., M. Dumas, J. Brown, T. C. Michaud, and W. J. Knowles. "SYNTHETIC PEPTIDE ANTIBODIES RECOGNIZE PLASMA AND RECOMBINANT FVIII." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644027.

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Monoclonal antibodies were raised against synthetic peptides corresponding to the N-termini of the 90kd and 80kd subunits of human FVIII. Preliminary screening was performed directly against the peptides (linked to albumin) coated onto polystyrene wells. IgG was purified by Protein A-Sepharose and affinity purified using the immunogen peptides linked to Sepharose. Immunoreactivity with both plasma and recombinant FVIII was compared by Western blotting, two-site ELISA employing a neutralizing rabbit anti-FVIII IgG as capture antibody, and inhibition in a fluid phase FVIII activity assay. None o
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Frazier, D., Shu Wha Lin, J. Ware, et al. "MAPPING OF 6 MONOCLONAL ANTIBODIES TO HUMAN FACTOR IX." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643565.

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In order to map the regions of human factor IX recognized by monoclonal antibodies we have inserted random fragments of the coding region of the cDNA for human factor IX into the lambda phage expression vector, lambda gtll. The resultant recombinant phage were screened with monoclonal antibodies, the immunoreactive phage were isolated, and the DNA of the inserted fragment was sequenced to determine which amino acids were immunoreactive. This data, coupled with data obtained from the use of specific fragments of human factor IX expressed in E. coli from a T7 phage promoter, has allowed us to ma
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Zimonina, A. A., E. Yu Prudnikova, and A. R. Imatdinov. "RECOMBINANT MONOCLONAL ANTIBODIES WITH VIRUS NEUTRALIZING ACTIVITY AGAINST SARS-COV-2 DELTA AND OMICRON VARIANTS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-81.

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The study describes the production and characterization of recombinant human monoclonal antibodies interacting with the receptor-binding domain of the Spike glycoprotein and possessing virus-neutralizing activity against SARS-CoV-2 variants Delta and Omicron.
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Leyte, A., R. F. Evers, and M. Ph Verbeet. "EPITOPE MAPPING OF HUMAN COAGULATION FACTOR VIII WITH IN VITRO SYNTHESIZED FRAGMENTS OF THE PROTEIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644043.

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We have used recombinant DNA techniques to map the epitopes of the coagulation Factor VIII for several monoclonal antibodies, raised against this protein. For this purpose, we cloned full- length- and partial Factor VIII cDNA sequences in the vector pSP64. Corresponding RNA fragments were synthesized in vitro with SP6 RNA polymerase and translated in a rabbit reticulocyte lysate system. The resulting Factor VII. I polypeptide fragments were immunoprecipitated. We have located the binding sites of a panel of monoclonal anti-Factor VIII antibodies. Two examples are shown in the figure below. The
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Günzler, W. A., B. Wolf, and L. Flohé. "CHARACTERIZATION OF RECOMBINANT HUMAN SINGLE-CHAIN LOW MOLECULAR WEIGHT UROKINASE (RE-SC-LUK)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643602.

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RE-SC-LUK obtained from recomoinant b. con Bacteria showed a molecular mass similar to that of recombinant two-chain LUK (RE-TC-LUK) as judged from SDS-PAGE. By “Western“ blot analysis immunoreactivity of RE-SC-LUK was observed with monoclonal antibodies directed against the B chain but not with those against the A1 chain of urokinase. N-terminal sequence analysis c RE-SC-LUK showed identity to the A, chain of RE-TC_LUK and provided evidence for its single-chain nature, i.e. integrity of the Lys-Ile bond which is split in TC-UK. In all other respects structural identity of RE-SC-LUK and RE-TC-
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Uzan, G., A. Lajmanovich, M. H. Prandini, Ph Frachet, A. Duperray, and G. Marguerie. "MOLECULAR CLONING OF PLATELET GPIIb FROM HEL CELLS AND HUMAN MEGAKARYOCYTES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643960.

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Platelet GP IIb-IIIa is an heterodimer which functions as a receptor for fibrinogen, fibronectin and Von Willebrand factor and is implicated in platelet adhesive reactions. To study the structure function relationship of this glycoprotein, a recombinant DNA approach was initiated. cDNA expression libraries were constructed in » gtll vector, from erythro-leukemia cells (HEL) and megakaryocytes mRNA. The human megakaryocytes were isolated from patients with chronic myeloid leukemia. The HEL library was initially screened with polyclonal antibodies anti GPIIb IIIa. One clone, λIIbI, containing a
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Higgins, Deborah L., and William E. Holmes. "CHARACTERIZATION OF RECOMBINANT HUMAN TISSUE-TYPE PLASMINOGEN ACTIVATOR MISSING THE FINGER DOMAIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643842.

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Site-specific mutagenesis was used to produce a mutant form of tissue-type plasminogen activator (t-PA) which was missing the first 44 amino acids. This domain has sequence homology with the type 1 regions in proteins such as fibronectin and is commonly called the finger domain. The mutant protein (des 1-44 t-PA) was expressed in Chinese Hampster Ovary cells, and was purified using chromatography on Zn-chelate sepharose and lysine-sepharose. Sequence analysis indicated that the resulting protein was homogeneous and started at amino acid 45 in the sequence of the normal protein. The two-chain f
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Hender, U., T. Lund-Hansen, and D. Winther. "COMPARISON OF THE EFFECT OF FACTOR VII PREPARED FROM HUMAN PLASMA (pVIIa) AND RECOMBINANT Vila (rVIIa) IN VITRO AND IN RABBITS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643788.

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Purified human FVIIa has been shown to induce haemostasis in pat. with haemoph. A compl. with antibodies against VIII:C (Hedner &amp; Kisiel 1983). The in vitro effect of addition of pVIIa or rVIIa was studied by adding 0, 44, or 180 u pVIIa/rVIIa/ml to haemoph. A or haemoph. B plasma. The APTT shortened from 61 s (mean of 5 determin.) without any Vila added to 38 s after addition of 44 u pVIIa to haemoph. A plasma, and to 33 s after addition of 180 u/ml. In haemoph. B plasma the corresponding APTTs were 64 s, 35 s (44 u pVIIa/ml Vila) and 31 s (180 u pVIIa/ ml). Similar results were obtained
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