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Relevant bibliographies by topics / Recombination activating genes

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Academic literature on the topic 'Recombination activating genes'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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Journal articles on the topic "Recombination activating genes"

1

Haines, Brian B., Chun Jeih Ryu, and Jianzhu Chen. "Recombination Activating Genes (RAG) in Lymphoma Development." Cell Cycle 5, no. 9 (2006): 913–16. http://dx.doi.org/10.4161/cc.5.9.2732.

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Panchin, Yuri, and Leonid L. Moroz. "Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes." Biochemical and Biophysical Research Communications 369, no. 3 (2008): 818–23. http://dx.doi.org/10.1016/j.bbrc.2008.02.097.

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Lamb, Teresa M., and Aaron P. Mitchell. "Coupling of Saccharomyces cerevisiae Early Meiotic Gene Expression to DNA Replication Depends Upon RPD3 and SIN3." Genetics 157, no. 2 (2001): 545–56. http://dx.doi.org/10.1093/genetics/157.2.545.

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Abstract It has been established that meiotic recombination and chromosome segregation are inhibited when meiotic DNA replication is blocked. Here we demonstrate that early meiotic gene (EMG) expression is also inhibited by a block in replication. Since early meiotic genes are required to promote meiotic recombination and DNA division, the low expression of these genes may contribute to the block in meiotic progression. We have identified three Hur– (HU reduced recombination) mutants that fail to couple meiotic recombination and gene expression with replication. One of these mutations is in RP

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Li, Tong-Tong, Shuhua Han, Mike Cubbage, and Biao Zheng. "Continued expression of recombination-activating genes and TCR gene recombination in human peripheral T cells." European Journal of Immunology 32, no. 10 (2002): 2792–99. http://dx.doi.org/10.1002/1521-4141(2002010)32:10<2792::aid-immu2792>3.0.co;2-i.

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Yannoutsos, Nikos, Patrick Wilson, Wong Yu, et al. "The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo." Journal of Experimental Medicine 194, no. 4 (2001): 471–80. http://dx.doi.org/10.1084/jem.194.4.471.

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Assembly of T cell receptor (TCR)α/β genes by variable/diversity/joining (V[D]J) rearrangement is an ordered process beginning with recombination activating gene (RAG) expression and TCRβ recombination in CD4−CD8−CD25+ thymocytes. In these cells, TCRβ expression leads to clonal expansion, RAG downregulation, and TCRβ allelic exclusion. At the subsequent CD4+CD8+ stage, RAG expression is reinduced and V(D)J recombination is initiated at the TCRα locus. This second wave of RAG expression is terminated upon expression of a positively selected α/β TCR. To examine the physiologic role of the second

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Ohmori, Hitoshi, та Masaki Hikida. "Expression and Function of Recombination Activating Genes in Mature В Cells". Critical Reviews™ in Immunology 18, № 3 (1998): 221–35. http://dx.doi.org/10.1615/critrevimmunol.v18.i3.30.

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Gennery, Andrew R., Elizabeth Hodges, Anthony P. Williams, et al. "Omenn's syndrome occurring in patients without mutations in recombination activating genes." Clinical Immunology 116, no. 3 (2005): 246–56. http://dx.doi.org/10.1016/j.clim.2005.04.014.

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Tsai, Albert G., and Michael R. Lieber. "RAGs found “not guilty”: cleared by DNA evidence." Blood 111, no. 4 (2008): 1750. http://dx.doi.org/10.1182/blood-2007-09-113381.

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A recent paper from the Alt laboratory shows that recombination activating genes (RAGs) are not responsible for double-strand DNA breaks associated with some chromosomal translocations in pre–T-cell lymphomas.

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Jessen, Jason R., Tammy N. Jessen, Steven S. Vogel, and Shuo Lin. "Concurrent expression of recombination activating genes 1 and 2 in zebrafish olfactory sensory neurons." genesis 29, no. 4 (2001): 156–62. http://dx.doi.org/10.1002/gene.1019.

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Oltz, E. M., F. W. Alt, W. C. Lin, et al. "A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination." Molecular and Cellular Biology 13, no. 10 (1993): 6223–30. http://dx.doi.org/10.1128/mcb.13.10.6223-6230.1993.

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Rapid analysis of mechanisms that regulate V(D)J recombination has been hampered by the lack of appropriate cell systems that reproduce aspects of normal prelymphocyte physiology in which the recombinase is activated, accessible antigen receptor loci are rearranged, and rearrangement status is fixed by termination of recombinase expression. To generate such a system, we introduced heat shock-inducible V(D)J recombination-activating genes (RAG) 1 and 2 into a recombinationally inert B-cell line. Heat shock treatment of these cells rapidly induced high levels of RAG transcripts and RAG proteins

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Dissertations / Theses on the topic "Recombination activating genes"

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Verkoczy, Laurent Karl. "Regulation studies of the human recombination activating genes, RAG-1 and RAG-2." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1995. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ51544.pdf.

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Hsu, Lih-Yun. "Regulation of recombination activating genes and B cell development by cis-activating elements and trans-acting protein pax-5." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080681.

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Zarrin, Ali Akbar. "Characterization of the human recombination activating gene 1 (RAG1) and RAG2 promoter regions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0024/NQ49915.pdf.

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Cabral, Barreto Vasco. "Allelic exclusion of the murine immunoglobulin heavy chain." Paris 6, 2001. http://www.theses.fr/2001PA066537.

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Bas, Anna. "Extrathymic T cell receptor gene rearrangement in human alimentary tract." Doctoral thesis, Umeå University, Clinical Microbiology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169.

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<p>T lymphocytes regulate the initiation, duration, and magnitude of adaptive immune responses and function as effector cells in cell mediated immunity. To become immunologically competent they must generate functional antigen receptors. This process takes place in the thymus and requires somatic recombination of T cell receptor (TCR) genes. It is mediated by the endonucleases recombination activating gene-1 (RAG1) and RAG2. Although the thymus regresses at puberty, T cells are present throughout life implying that other tissues must provide the proper milieu for T cell development. This thesi

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Kumari, Rupa. "Mechanism of RAG Regulation During Its Physiological and Pathological Functions in Lymphoid Cells." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3944.

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RAGs (Recombination Activating Genes) are responsible for generation of antigen receptor diversity in case of B-cells and T-cells, through the process of combinatorial joining of different V (variable), D (diversity) and J (joining) gene segments. Each of these segments are flanked by recombination signal sequences (RSS), which consist of a conserved heptamer and nonamer separated by a less conserved spacer of 12 or 23 bp. RAGs recognize and cleave at the 5’ end of heptamer, leading to the formation of hairpin coding ends and blunt signal ends. The coding ends are joined through the process o

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Kumari, Rupa. "Mechanism of RAG Regulation During Its Physiological and Pathological Functions in Lymphoid Cells." Thesis, 2015. http://etd.iisc.ernet.in/2005/3944.

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RAGs (Recombination Activating Genes) are responsible for generation of antigen receptor diversity in case of B-cells and T-cells, through the process of combinatorial joining of different V (variable), D (diversity) and J (joining) gene segments. Each of these segments are flanked by recombination signal sequences (RSS), which consist of a conserved heptamer and nonamer separated by a less conserved spacer of 12 or 23 bp. RAGs recognize and cleave at the 5’ end of heptamer, leading to the formation of hairpin coding ends and blunt signal ends. The coding ends are joined through the process o

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Paranjape, Amita M. "Understanding the Mechanism of Noncanonical Functions of RAGs in Lymphoid Cancer and Glioblastoma." Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5677.

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Recombination activating genes (RAGs) composed of RAG1 and RAG2, are the endonuclease involved in V(D)J recombination, which is critical for adaptive immunity in mammals. Activation-induced cytidine deaminase (AID), expressed in germinal B cells, deaminates CpG/ methylated CpG, generating single nucleotide mismatch of either U/G or T/G. Several studies suggest that RAGs and AID are the key players responsible for the generation of chromosomal translocations. In summary, noncanonical functions of RAGs were explored in the present study. In the first part, we investigated whether a combination

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Wang, Ya-Jean, and 王雅貞. "Cloning recombination activating gene 1 and 2 ( rag1 and rag2 ) and analyzing of the genes expression in adaptive immunity ontogenesis of Orange-Spotted Grouper (Epinephelus coioides)." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/38350825233940536103.

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碩士<br>國立成功大學<br>生物學系碩博士班<br>97<br>Orange-spotted grouper (Epinephelus coioides) is a fish species with a high economic importance in the aquaculture industry in Taiwan. The high mortalities observed throughout early development such as viral nervous necrosis (VNN) causes the highest mortalities up to 100% always occur among 1-month-old larvae with total body lengths of 2.0 cm. Teleost is the oldest species has the adaptive immune system. However, there is a risk of inducing immunological tolerance if fish that are immunised at a very early age before they are immunocompetent. Thus, it is impor

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Naik, Abani Kanta. "Mechanism Of RAG Action As A Structure-Specific Nuclease : Implications In Genomic Instability In Lymphoid Cells." Thesis, 2011. https://etd.iisc.ac.in/handle/2005/2127.

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Recombination Activating Genes (RAGs) orchestrate the process called V (D) J recombination, which enables the vertebrate adaptive immune system to specifically recognize millions of antigens. During this recombination process, V (variable), D (diversity) and J (joining) gene segments of antibody (B cell receptor) and TCR (T cell receptor) join by different possible combinations to generate antigen receptor diversity. This unique site specific recombination process is actuated by lymphoid specific proteins called RAG1 and RAG2 (RAGs or RAG complex). RAGs recognize a conserved sequence motif fla

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Books on the topic "Recombination activating genes"

1

Verkoczy, Laurent Karl. Regulation studies of the human recombination activating genes (RAG-1 and RAG-2). National Library of Canada, 1995.

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2

Joyner, Alexandra, ed. Gene Targeting. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637928.001.0001.

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Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications. As with the previous edition Gene Targeting: A Practical Approach 2e concentrates on gene targeting in mouse ES cells, but the techniques described can be easily adapted to applications in tissue culture including those for human cells. The first

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Voll, Reinhard E., and Barbara M. Bröker. Innate vs acquired immunity. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048.

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The innate and the adaptive immune system efficiently cooperate to protect us from infections. The ancient innate immune system, dating back to the first multicellular organisms, utilizes phagocytic cells, soluble antimicrobial peptides, and the complement system for an immediate line of defence against pathogens. Using a limited number of germline-encoded pattern recognition receptors including the Toll-like, RIG-1-like, and NOD-like receptors, the innate immune system recognizes so-called pathogen-associated molecular patterns (PAMPs). PAMPs are specific for groups of related microorganisms

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Book chapters on the topic "Recombination activating genes"

1

Hansen, J. D., and J. F. McBlane. "Recombination-Activating Genes, Transposition, and the Lymphoid-Specific Combinatorial Immune System: A Common Evolutionary Connection." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-59674-2_6.

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Teubl, Fabian, Katrin Schwank, Uli Ohmayer, Joachim Griesenbeck, Herbert Tschochner, and Philipp Milkereit. "Tethered MNase Structure Probing as Versatile Technique for Analyzing RNPs Using Tagging Cassettes for Homologous Recombination in Saccharomyces cerevisiae." In Ribosome Biogenesis. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_8.

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AbstractMicrococcal nuclease (MNase) originating from Staphylococcus aureus is a calcium dependent ribo- and desoxyribonuclease which has endo- and exonucleolytic activity of low sequence preference. MNase is widely used to analyze nucleosome positions in chromatin by probing the enzyme’s DNA accessibility in limited digestion reactions. Probing reactions can be performed in a global way by addition of exogenous MNase, or locally by “chromatin endogenous cleavage” (ChEC) reactions using MNasefusion proteins. The latter approach has recently been adopted for the analysis of local RNA environmen

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Hamaguchi, Yasushi, Norisada Mastunami, Yoshiki Yamamoto, et al. "Cloning and Characterization of a Protein Binding to the Jκ Recombination Signal Sequence of Immunoglobulin Genes." In Mechanisms of Lymphocyte Activation and Immune Regulation III. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5943-2_20.

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Govindarajan, Priyanka, Jonathan P. Rast, and Mani Larijani. "Evolution of Recombination-Activating Genes (RAG) and Activation-Induced Cytidine Deaminase (AID)." In Reference Module in Life Sciences. Elsevier, 2024. http://dx.doi.org/10.1016/b978-0-128-24465-4.00046-6.

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Johnson, Reid C. "|Site-specific recombinases and their interactions with DNA." In DNA-Protein: Structural Interactions. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780199634545.003.0006.

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Abstract Site-specific recombination reactions are associated with a wide range of biological processes, especially where generation of genetic diversity is a principal goal. For example, regulatory mechanisms involving site-specific inversion reactions have enabled bacteria to evade host immunity systems by regulating the expression of multiple surface proteins (1). Viruses have evolved highly regulated site-specific recombination systems to integrate into, and excise from, host chromosomes (2). These reactions also play important roles in the partitioning of chromosomes (3, 4) and in the sel

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Torres, Raul M., and Ralf Kühn. "LoxP-containing transgenes." In Laboratory Protocols for Conditional Gene Targeting. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780199636778.003.0010.

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Abstract As discussed in the previous chapters the Cre/loxP system offers a variety of possibilities in the manipulation of targeted endogenous genes - both in the ES cell genome and mice derived from them. Moreover, Cre recombinase can be also used to activate (or inactivate) in vivo loxP interrupted, randomly integrated transgenes introduced into the mouse gerrnline either by pronucleus injection or the ES cell route. Similar to the conditional gene targeting strategy (Figure 13), transgene expression can be controlled by the pattern of Cre expression in vivo, i.e., in a tissue¬ specific or

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Playfair, John H. L., and Gregory J. Bancroft. "Disease due to adaptive immunity II: autoimmunity." In Infection and Immunity. Oxford University Press, 2013. http://dx.doi.org/10.1093/hesc/9780199609505.003.0026.

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This chapter discusses the underlying causes of autoimmunity, focusing on infection and genetic predisposition. It seeks to understand how autoimmunity is normally avoided, and why do some B and T lymphocytes do not recognize and respond to 'self' antigens, considering that their receptors are produced by a random recombination of genes and should be able to recognize virtually everything, instead of being unresponsive, or tolerant, to self. The chapter begins by analyzing the polyclonal activation of anti-self B or T lymphocytes. It then looks into the activation of T lymphocytes by antigens

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Voll, Reinhard E., and Barbara M. Bröker. "Innate vs acquired immunity." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048_update_001.

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The innate and the adaptive immune system efficiently cooperate to protect us from infections. The ancient innate immune system, dating back to the first multicellular organisms, utilizes phagocytic cells, soluble antimicrobial peptides, and the complement system for an immediate line of defence against pathogens. Using a limited number of germline-encoded pattern recognition receptors including the Toll-like, RIG-1-like, and NOD-like receptors, the innate immune system recognizes so-called pathogen-associated molecular patterns (PAMPs). PAMPs are specific for groups of related microorganisms

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Conference papers on the topic "Recombination activating genes"

1

Hu, Jiazhi, Yu Zhang, Lijuan Zhao, et al. "Abstract A180: Topologically associated domains genome-wide restrict the off-target activity of recombination activating gene 1/2 endonuclease." In Abstracts: CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr15-a180.

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Reports on the topic "Recombination activating genes"

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Hodges, Thomas K., and David Gidoni. Regulated Expression of Yeast FLP Recombinase in Plant Cells. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7574341.bard.

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Research activities in both our laboratories were directed toward development of control of the FLP/frt recombination system for plants. As described in the text of the research proposal, the US lab has been engaged in developing regulatory strategies such as tissue-specific promoters and the steroid-inducible activation of the FLP enzyme while the main research activities in Israel have been directed toward the development and testing of a copper-regulated expression of flp recombinase in tobacco (this is an example of a promoter activation by metal ions). The Israeli lab hat additionally com

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Norelli, John L., Moshe Flaishman, Herb Aldwinckle, and David Gidoni. Regulated expression of site-specific DNA recombination for precision genetic engineering of apple. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7587214.bard.

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Objectives: The original objectives of this project were to: 1) evaluate inducible promoters for the expression of recombinase in apple (USDA-ARS); 2) develop alternative selectable markers for use in apple to facilitate the positive selection of gene excision by recombinase (Cornell University); 3) compare the activity of three different recombinase systems (Cre/lox, FLP/FRT, and R/RS)in apple using a rapid transient assay (ARO); and 4) evaluate the use of recombinase systems in apple using the best promoters, selectable markers and recombinase systems identified in 1, 2 and 3 above (Collabor

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