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Journal articles on the topic 'Recruitment and requirement profile'
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1
James, Julie M., Dipak Kalra, and Jane Portlock. "Analysis of Requirements for the Medication Profile to Be Used in Clinical Research: Protocol Feasibility Studies and Patient Recruitment." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/932935.
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A “Medication Profile,” the information about the medicines a person is using and has used, is a core part of many electronic health record systems and summaries. However, there is little objective research into the data elements that the profile should contain to support the uses it must serve. With the increasing emphasis on secondary uses of electronic health information, as well as supporting the requirements to support direct to patient care, the Medication Profile should also support the requirements from clinical research. However, there is little, if any, description of these available. This paper describes an analysis of a set of study eligibility criteria that was undertaken to investigate which medication-related data elements would be required to support two clinical research use cases: the parameters to query a patient’s Medication Profile to assess their suitability for entry into a trial (patient recruitment) and the parameters to query a set of Medication Profiles in a data warehouse to assess whether the eligibility criteria as described would yield a reasonable cohort of patients as potential subjects (protocol feasibility). These medication-related data elements then become information requirements that a Medication Profile should ideally meet, in order to be able to support these two uses in the clinical research domain.
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Matthews, Derek. "THE SOCIAL CLASS, EDUCATIONAL BACKGROUND, GENDER AND RECRUITMENT OF AMERICAN CPAs: AN HISTORICAL PROFILE." Accounting Historians Journal 43, no. 1 (2016): 121–55. http://dx.doi.org/10.2308/0148-4184.43.1.121.
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This article summarises the existing evidence of the earliest CPAs and offers new data as a result of a questionnaire survey and interviews with CPAs with regard to their social class, gender, education, and the nature of their first employment. From the start CPAs were from a relatively high social class and from families of long standing in America. A majority but not all of the early CPAs graduated from high school but this soon became a requirement. Most of the first CPAs did not go to college but accounting became virtually an all-graduate profession by the Second World War. The questionnaire evidence from the 1930s to the present day indicates that 50% of the respondents came from the upper middle class, around 30% from the lower middle class, and 20% from the working class; these proportions did not change over the period of the study. A large majority of the CPAs in the survey were educated at their local high schools and their home-state public universities. The structure and changes in the US education system seemed to have little impact on the social class of the CPA respondents. Accounting firms recruited 85% of the sample and the rest joined commercial or public concerns. No strong preference was found among the various types of employer with regard to the gender, education or the social class of their recruits. Recruiters attempted to hire the best candidates they could regardless of these factors.
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John Bullied, W., Rene C. Van Acker, and Paul R. Bullock. "Review: Microsite characteristics influencing weed seedling recruitment and implications for recruitment modeling." Canadian Journal of Plant Science 92, no. 4 (2012): 627–50. http://dx.doi.org/10.4141/cjps2011-281.
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Bullied, W. J., Van Acker, R. C. and Bullock, P. R. 2012. Review: Microsite characteristics influencing weed seedling recruitment and implications for recruitment modeling. Can. J. Plant Sci. 92: 627–650. A weed seedling recruitment microsite is the location of a weed seed in the soil profile which affects germination, time of emergence and seedling establishment. The relationship between the recruitment of seedlings and their physical environment, including microclimate, soil, topography, and residue cover can provide the key to understanding the timing of seedling recruitment. The variability that exists in germination and establishment requirements within and among weed species raises important questions for recruitment research addressing multiple species, as well as regional models of genetic variability within species. Current weed recruitment research focuses mainly on summer annual species in annual cropping systems. However, with changes in cropping systems, climate, and weed biology, there will be an increasing demand for the management of both summer and winter annual weeds that develop very early in the spring. Many studies to date take an average of microsite conditions, particularly for soil depth, to describe the seedling recruitment zone. Whereas this practice of under-sampling expedites lengthy and difficult soil environmental measurements, it limits the description of the microsite for predictive purposes. Because soil disturbance disperses seeds to microsites throughout the vertical profile of the shallow seedling recruitment zone, seeds are subjected to gradients of temperature and water that create diverse microsites with depth in the recruitment zone. Research on the interactions of microclimate, field topography, soil properties and agronomic practices can further our knowledge base of the seedling recruitment microsite to better understand weed ecology and population dynamics generally, as well as enhance our ability to predict seedling recruitment specifically.
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Loginova, M. A., and I. V. Paramonov. "Development strategy of the registry of donors of hematopoietic stem cells." Russian Journal of Pediatric Hematology and Oncology 7, no. 4 (2021): 35–42. http://dx.doi.org/10.21682/2311-1267-2020-7-4-35-42.
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Aim of the study — to develop a strategy for the recruiting potential donors to the registry, which is based on the biological characteristics of russian populations.Materials and methods. The object of the study was 35,117 potential donors of the hematopoietic stem cells of the registry of KRIHBT FMBA of Russia, recruited in 22 subjects of the Russian Federation.Results. Based on a comparison of the HLA-A-B-C-DRB1 haplotype profiles of local donor populations, calculated using the EM-algorithm in the Arlequin v.3.5.2.2 software, with the profile of the pooled donor population of the registry, general requirements for the recruitment of potential hematopoietic stem cells donors to the registry were formulated.
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Barber, Ellen M., Melissa Fazzari, and Jeffrey W. Pollard. "Th1 Cytokines Are Essential for Placental Immunity to Listeria monocytogenes." Infection and Immunity 73, no. 10 (2005): 6322–31. http://dx.doi.org/10.1128/iai.73.10.6322-6331.2005.
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ABSTRACT The fetal allograft poses an immunological challenge: how is it protected while immunity to pathogens, particularly those that replicate in the placenta, is maintained? Several theories have been proposed to explain this fetal protection, including a pregnancy-based bias towards a Th2 rather than Th1 cytokine profile in order to avoid generating cytotoxic T cells that could threaten the fetus. Listeria monocytogenes preferentially replicates in the placenta and systemically requires a Th1 response for sterile eradication. In the placenta, the Th1 cytokines tumor necrosis factor alpha (TNF-α) and gamma interferon (IFN-γ) are also synthesized in response to this pathogen, without fetal loss. Here we show, by using mice homozygous for null mutations in either the cytokine or cytokine receptor genes, a requirement for both TNF-α and IFN-γ signaling for an effective placental immune response to L. monocytogenes. However, T cells were not recruited to the placenta. Genetic studies in which the fetal component of the placenta was genetically different from the mother indicated that both the production of and response to these cytokines were maternal. Despite the requirement for these cytokines, the early recruitment of neutrophils to the placenta was normal. Consequently, the bacterium appeared to be delayed in its colonization of this organ and did not fully gain hold until 72 h postinfection. These data show a requirement for Th1 cytokines during pregnancy for effective immunity and indicate that a bias away from Th1 cytokine synthesis is not a necessary prerequisite of pregnancy.
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Zenz, Adrian, and James Leibold. "Securitizing Xinjiang: Police Recruitment, Informal Policing and Ethnic Minority Co-optation." China Quarterly 242 (July 12, 2019): 324–48. http://dx.doi.org/10.1017/s0305741019000778.
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AbstractFollowing a series of high-profile attacks in Beijing, Kunming and Urumqi by Uyghur militants, the Chinese party-state declared a “war on terror” in 2014. Since then, China's Xinjiang region has witnessed an unprecedented build-up of what we describe as a multi-tiered police force, turning it into one of the most heavily policed regions in the world. This article investigates the securitization of Xinjiang through an analysis of official police recruitment documents. Informal police jobs, which represent the backbone of recent recruitment drives, have historically carried inferior pay levels. Yet, advertised assistant police positions in Xinjiang now offer high salaries despite low educational requirements, thereby attracting lesser-educated applicants, many of whom are ethnic minorities. Besides co-opting Uyghurs into policing their own people, the resulting employment is in itself a significant stability maintenance strategy. While the known numbers of violent attacks have subsided, China's heavy-handed securitization approach risks alienating both minority and Han populations.
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Arnold, Michael A., and Christine D. Townsend. "Implications of an Analysis of Job Newsletter Content, Readership, and Perceived Value for Student Advisement and Curriculum Development." HortTechnology 7, no. 1 (1997): 84–90. http://dx.doi.org/10.21273/horttech.7.1.84.
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Recipients of a monthly horticultural job opportunities newsletter and firms or organizations listing positions in the newsletter were surveyed to determine the perceived value of the newsletter as a job search and recruitment tool, respectively. Survey information was used to develop a profile of the individuals and organizations using the newsletter. Original position descriptions on which the briefer newsletter listings were based were used to develop a profile of the industry segment, degree and/or experience requirements, geographic location, and starting salaries and benefits of positions listed from January 1993 to December 1994. While the newsletter generated contact between prospective employees and employers, only 20% of the prospective employees received job offers by responding to newsletter listings. The newsletter was valued more by individual recipients as a job search tool than by institutional recipients or private industry as a recruitment tool. Starting salaries of listed positions were comparable to those previously reported in industry and academic surveys. Foreign language skills and previous work experience were requested more frequently than above-minimum (typically 2.00) grade point averages or completion of government or industry certification programs. Landscape-related disciplines constituted most BS or BA positions listed, whereas advanced degree positions were distributed more evenly over horticulture-related disciplines. Data supported the inclusion of internship programs and foreign language requirements in horticulture curricula.
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Li, Yonghong, Chaojun Wei, Hui Xu, et al. "The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection." Mediators of Inflammation 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/6587296.
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T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF-β, IL6, IL21, and IL23). Recent studies involving experimental animals and humans have shown that Th17/IL17 plays a crucial role in host defense against a variety of pathogens, including bacteria and viruses. The underlying mechanisms by which Th17 performs include dendritic cell (DC) regulation, neutrophil recruitment, Th1 modulation, and T regulatory cell (Treg) balance. In recent years, researchers have generated an accumulating wealth of evidence on the role of Th17/IL17 in protective immunity to intracellular bacterial pathogens, such asMycobacterium tuberculosisandChlamydia trachomatis, which are one of the most important pathogens that inflict significant socioeconomic burden across the globe. In this article, we reviewed the current literature on the functions and mechanisms by which Th17/IL17 responds to intracellular bacterial infections. A better understanding of Th17/IL17 immunity to pathogens would be crucial for developing effective prophylactics and therapeutics.
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Arnold, Michael A., and Christine D. Townsend. "PROFILING THE TEXAS A&M HORTICULTURE JOB OPPORTUNITIES NEWSLETTER: CONTENT, READERSHIP, AND PERCEIVED VALUE." HortScience 31, no. 5 (1996): 754c—754. http://dx.doi.org/10.21273/hortsci.31.5.754c.
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A sample of individual and institutional recipients of a monthly horticultural job opportunities newsletter and firms/organizations listing positions in the newsletter were surveyed to determine the perceived value of the newsletter as a job search tool and recruitment tool, respectively. Survey information was also used to develop a profile of the individuals and organizations using the newsletter. Original position descriptions on which the briefer newsletter listings were based were used to develop a profile of the industry segment, degree/experience requirements, geographic location, and starting salaries/benefits of positions listed between Jan. 1993 and Dec. 1994. While the newsletter generated contact between prospective employees and employers, only 20% of the prospective employees received job offers by responding to newsletter listings. Individual recipients valued the newsletter as a job search tool more than institutional recipients, or private industry as a recruitment tool. Starting salaries of listed positions were comparable to those previously reported in industry and academic surveys. Foreign language skills and previous work experience were more frequently requested than above minimum grade point averages or completion of government/industry certification programs. Landscape-related disciplines constituted the majority of BS/BA positions listed, where advanced degree positions were more evenly distributed over horticulture-related disciplines.
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do Vale, João Walter Saunders Pacheco, Breno Nunes, and Marly Monteiro de Carvalho. "Project Managers’ Competences." Project Management Journal 49, no. 3 (2018): 82–97. http://dx.doi.org/10.1177/8756972818770884.
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This article investigates the individual competences of project managers through a methodological approach that combines a systematic literature review and an analysis of employment opportunities. A comparative analysis of project manager’s competences from the literature and the job advertisements was done. The systematic literature review was the first stage of the research and consisted of adopting methods of bibliometrics and content analysis. The second stage included an analysis of project managers’ competences in the selection process. Thus, five Brazilian recruitment websites and the selection of employees were investigated. Through literature review, it was possible to classify and code competences in four categories (contextual, managerial, technical, and behavioral). The analysis of job advertisements allowed us to identify core competence requirements in the job descriptions and to develop a project manager profile expected by Brazilian organizations.
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Brito, Pedro Quelhas, and Meena Rambocas. "Assessing the impact of mystery client traits on service evaluation." Journal of Services Marketing 30, no. 4 (2016): 411–26. http://dx.doi.org/10.1108/jsm-01-2015-0004.
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Purpose This study aims to investigate the reliability of a mystery client (MC) as a service evaluation technique taking into consideration personal differences of the MC agents. Design/methodology/approach The ratings from 144 MCs from 355 evaluations of computer and electronic stores were cross analyzed with eight psychographic and demographic profile variables. Findings MCs who were highly involved in the product category were more critical of service responsiveness with respect to product demonstrations and listening to customer requirements. On the other hand, MCs with stronger faith in intuition were more inclined to rate services higher on empathy with respect to employees making a conscientious effort to understand customers’ needs. Practical implications Depending on the service marketing goals, managers learn to define which aspects of MC profile they should consider or avoid during the recruitment as well as becoming more critical when they analyze the evaluation reports to avoid an interpretation bias. Originality/value The usefulness of the MC tool relies on its reliability and credibility as a marketing research technique. It was identified that the MC personality traits are more likely associated with marketing service evaluation variability.
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Brits, G. J., and J. C. Manning. "Seed structure and physiology in relation to recruitment ecology in Leucospermum (Proteaceae) in fynbos." Australian Journal of Botany 67, no. 4 (2019): 290. http://dx.doi.org/10.1071/bt18199.
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Development of embryo envelopes in Leucospermum cordifolium (Salisb. ex Knight) Fourcade is presented in a detailed anatomical study, and their structure interpreted ecologically. To support interpretation results for at least six other species of Leucospermum are reviewed, confirming that L. cordifolium is representative of this shrubby group occurring in fynbos, a fire-prone Mediterranean-type vegetation subject to summer drought. The fate of the water-permeable seed coverings subsequent to dispersal is followed in seeds stored experimentally underground. The testa at maturity effectively excludes oxygen in intact soil-stored seeds, thus creating a less common type of physical dormancy which we term ‘anoxia PY’ (oxygen-impermeable physical dormancy). We postulate ‘fire-mediated desiccation-scarification’ testa breakage on a large scale in freshly dispersed (by ants) soil-stored young-seeds, dynamically regulated by drying of different testa layers through fire heat shock (but also by post-fire ambient climate heat), thus alleviating anoxia PY in, and causing undelayed germination of, a major part of the young-seed bank within the ensuing winter germination season. Concurrently a patchy disturbance pattern within a lesser portion of the young-seed cohort causes uneven underground desiccation-scarification by fire, resulting in variable degrees of oxygenation and thus temporally extended (erratic) germination of young-seeds. Both of these strategies are primary long term fitness traits in Leucospermum. By contrast the persistent older-seed cohort, stored underground during the inter-fire period, may become weathered by soil and climate factors (‘soil-mediated abrasion’), which alleviates anoxia PY in old seeds. Thermodormancy of these embryos (physiological dormancy, PD) is enforced in unburnt vegetation by two narrow habitat-dependent daily temperature requirements (~10°C × 20°C), and these have specific ecological functions. The complex Leucospermum system includes balanced adaptive responses to multiple selective pressures. We propose a coherent mechanistic profile for this fynbos genus, synthesising data partly from the literature of other fire-prone ecosystems.
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Rosales Escobar, María Leonor, and Margarita Silvestre Oramas. "Caracterización de un modelo de enseñanza del docente de nivel superior." Foro Educacional, no. 25 (September 5, 2016): 11. http://dx.doi.org/10.29344/07180772.25.810.
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RESUMENLa presente investigación se enfocó en la práctica docente de los profesores de una institución de Educación Superior, cuya contratación se realiza considerando como requisito principal su perfil profesional. El propósito fue observar si existen diferencias significativas entre el Modelo Educativo rector de la institución y el Modelo actuante, mediante trece indicadores que impactan directamente en el proceso de enseñanza y aprendizaje. La investigación se desarrolló con una metodología mixta, a través de encuestas a docentes y estudiantes, registros de observación en el aula y el análisis estadístico de resultados. Los hallazgos encontrados muestran que el modelo de enseñanza de los profesores sigue un enfoque tradicional, que difiere del Modelo Educativo rector que se aspira en la institución.Palabras clave: Modelo Educativo, docente, nivel superior, enseñanza, aprendizaje.Characterization of a model of teaching teacher of upper levelABSTRACTThis research focused on the teaching practice of teachers in an institution of higher education, whose recruitment is carried out considering the main requirement professional profile. The purpose was to observe whether there are significant differences between the guiding educational model of the school and the acting model by thirteen indicators that directly impact the teaching and learning process. The research was conducted with a mixed methodology through surveys to teachers and students, records classroom observation and statistical analysis of results. The findings show that the model teachers teaching follows a traditional approach, which differs from the guiding educational model that is desirable into the institution.Key words: Educational model, teacher, higher level, teaching, learning.
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Kinyamu, H. Karimi, Brian D. Bennett, Pierre R. Bushel, and Trevor K. Archer. "Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity." Journal of Biological Chemistry 295, no. 5 (2019): 1271–87. http://dx.doi.org/10.1074/jbc.ra119.011174.
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Proteasome activity is required for diverse cellular processes, including transcriptional and epigenetic regulation. However, inhibiting proteasome activity can lead to an increase in transcriptional output that is correlated with enriched levels of trimethyl H3K4 and phosphorylated forms of RNA polymerase (Pol) II at the promoter and gene body. Here, we perform gene expression analysis and ChIP followed by sequencing (ChIP-seq) in MCF-7 breast cancer cells treated with the proteasome inhibitor MG132, and we further explore genome-wide effects of proteasome inhibition on the chromatin state and RNA Pol II transcription. Analysis of gene expression programs and chromatin architecture reveals that chemically inhibiting proteasome activity creates a distinct chromatin state, defined by spreading of the H3K4me3 mark into the gene bodies of differentially-expressed genes. The distinct H3K4me3 chromatin profile and hyperacetylated nucleosomes at transcription start sites establish a chromatin landscape that facilitates recruitment of Ser-5- and Ser-2–phosphorylated RNA Pol II. Subsequent transcriptional events result in diverse gene expression changes. Alterations of H3K36me3 levels in the gene body reflect productive RNA Pol II elongation of transcripts of genes that are induced, underscoring the requirement for proteasome activity at multiple phases of the transcriptional cycle. Finally, by integrating genomics data and pathway analysis, we find that the differential effects of proteasome inhibition on the chromatin state modulate genes that are fundamental for cancer cell survival. Together, our results uncover underappreciated downstream effects of proteasome inhibitors that may underlie targeting of distinct chromatin states and key steps of RNA Pol II–mediated transcription in cancer cells.
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Baker, Jeanette, Andreas Beilhack, Lu-en Wai, et al. "Inflammatory TH1 Cytokines in Target Tissues Promote the Recruitment of Alloreactive T Cells in Graft-Versus-Host Disease." Blood 114, no. 22 (2009): 2451. http://dx.doi.org/10.1182/blood.v114.22.2451.2451.
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Abstract Abstract 2451 Poster Board II-428 Hematopoietic cell transplantation (HCT) is a curative therapy for a variety of malignancies. HCT provides disease eradication through both the high-dose conditioning regimen and an allogeneic graft versus tumor effect (GVT), however graft-versus-host disease (GVHD) remains a major obstacle. In a murine aHCT model of bioluminescence imaging (BLI) we have previously demonstrated that acute GVHD can be separated to a GVHD initiation phase confined to secondary lymphoid organs and a subsequent GVHD effector phase in peripheral target tissues. It has been proposed that host conditioning may not only be crucial in the activation of alloreactive T cells but also determine acute GVHD organ manifestation in the effector phase. Here we wanted to investigate how the host conditioning regimen affects the host target tissues in terms of inflammatory cytokines and their role in donor T cell recruitment. We compared lethally irradiated (8Gy) vs. non-irradiated Balb/c wild type or Balb/c Rag-/-cGC-/- (H-2d) -DKO mice that received allogeneic luciferase+ FVB/N T cells (H-2q). Surprisingly, we did not observe marked differences in the donor T cell proliferation (BLI, CFSE), acquisition of activation markers (CD25, CD44, CD69) and homing receptors (a4b7, aEb7, P-selectin ligand, E-selecting ligand) in conditioned, non-conditioned Balb/c Rag-/-cGC-/-. Despite the upregulation of these homing receptors on donor T cells, infiltration of target tissues (intestinal tract, liver and skin) was significantly accelerated in conditioned and delayed in non-conditioned hosts. As T cell recruitment may have occurred as a result of alterations of the milieu inflammatory cytokines in GVHD target tissues, we compared the cytokine profile in conditioned vs. non-conditioned recipients. At days 3 and 6 after transplantation tissues were harvested and cytokines from the target tissues; liver, large bowel, small bowel, peripheral blood and a non target tissue: kidney were analyzed for a TH1/TH2/Th17a cytokines. At day 3 high levels of INF-γ and TNF were detected in the Balb/c WT conditioned host compared to the non-conditioned host in all target tissues (SB, LB, and liver) and most markedly in peripheral blood and the large bowel. More importantly the Balb/c Rag-/-cGC-/- conditioned host displayed about 5 times higher levels of both inflammatory cytokines compared to the non conditioned DKO hosts and to the Balb/c WT. Similar results with a lesser levels were observed both for IL-2 and IL17a. By day 6 similar results are seen but with a much reduced expression of the cytokines, indicating that the cytokine storm peak was maybe at day 3. In summary host conditioning is not a requirement for alloreactive T cell activation rather induced inflammatory cytokines such as TNF and INF-γ are the determinant factors for effector T cell recruitment to GVHD target tissues. JB and AB contributed equally to this work. Disclosures: No relevant conflicts of interest to declare.
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Sydes, Matthew R., Yolanda Barbachano, Louise Bowman, et al. "Realising the full potential of data-enabled trials in the UK: a call for action." BMJ Open 11, no. 6 (2021): e043906. http://dx.doi.org/10.1136/bmjopen-2020-043906.
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RationaleClinical trials are the gold standard for testing interventions. COVID-19 has further raised their public profile and emphasised the need to deliver better, faster, more efficient trials for patient benefit. Considerable overlap exists between data required for trials and data already collected routinely in electronic healthcare records (EHRs). Opportunities exist to use these in innovative ways to decrease duplication of effort and speed trial recruitment, conduct and follow-up.ApproachThe National Institute of Health Research (NIHR), Health Data Research UK and Clinical Practice Research Datalink co-organised a national workshop to accelerate the agenda for ‘data-enabled clinical trials’. Showcasing successful examples and imagining future possibilities, the plenary talks, panel discussions, group discussions and case studies covered: design/feasibility; recruitment; conduct/follow-up; collecting benefits/harms; and analysis/interpretation.ReflectionSome notable studies have successfully accessed and used EHR to identify potential recruits, support randomised trials, deliver interventions and supplement/replace trial-specific follow-up. Some outcome measures are already reliably collected; others, like safety, need detailed work to meet regulatory reporting requirements. There is a clear need for system interoperability and a ‘route map’ to identify and access the necessary datasets. Researchers running regulatory-facing trials must carefully consider how data quality and integrity would be assessed. An experience-sharing forum could stimulate wider adoption of EHR-based methods in trial design and execution.DiscussionEHR offer opportunities to better plan clinical trials, assess patients and capture data more efficiently, reducing research waste and increasing focus on each trial’s specific challenges. The short-term emphasis should be on facilitating patient recruitment and for postmarketing authorisation trials where research-relevant outcome measures are readily collectable. Sharing of case studies is encouraged. The workshop directly informed NIHR’s funding call for ambitious data-enabled trials at scale. There is the opportunity for the UK to build upon existing data science capabilities to identify, recruit and monitor patients in trials at scale.
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Jeong, Soon S., Marinus J. Broekman, Timothy A. Mitsky, Ridong Chen, and Aaron J. Marcus. "Antithrombotic Activity of a Novel Engineered Human Apyrase. Enzymatic Profile, Ex Vivo and In Vivo Properties." Blood 104, no. 11 (2004): 530. http://dx.doi.org/10.1182/blood.v104.11.530.530.
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Abstract Recent emphasis has been on ADP as a mediator of thrombotic events characterized by excessive platelet reactivity. In contrast, neither ATP nor AMP induces platelet activation. Thus, (enzymatic) removal of ADP from the milieu of activated platelets constitutes a novel antithrombotic strategy. Apyrases constitute a group of enzymes catalyzing metabolism of ATP to ADP, and ADP to AMP. Therefore, we cloned a human apyrase isozyme with 35% sequence identity to CD39 (NTPDase1) from a human genome cDNA library and enhanced its ADPase activity by protein engineering. The novel engineered apyrase, named APT102 was transfected into and secreted from HEK293 cell lines. It was purified from conditioned medium using anion exchange chromatography, size exclusion chromatography and affinity chromatography, and enzymatically characterized. APT102 was highly soluble and stable. It exhibited a 2.5-fold increase in ADPase activity relative to its ATPase activity, when compared to the parent compound, with catalytic efficiencies (Vmax/Km) of 0.135 and 0.164 respectively. APT102 strongly inhibited platelet reactivity in vitro when added to citrated and heparinized human platelet-rich plasma upon stimulation with ADP or collagen. ATP is released upon tissue damage and could potentially lead to formation of prothrombotic levels of ADP following its metabolism by apyrases. We demonstrated that with APT102, aggregation was efficiently inhibited and reversed by the enzyme. This occurred even when human platelets were initially stimulated with 10 μM ADP simultaneously with up to 100 μM ATP, followed within 5 min with another dose of 300 μM ATP. Following tail vein infusion of APT102 to male Sprague-Dawley rats (~300 g) at 0.75 mg/kg body weight, platelet aggregation ex vivo in PRP in response to ADP and collagen was strongly inhibited. The pharmacokinetics of APT102 were determined by enzyme activity assays with either ADP or ATP as substrate, as analyzed by our radio-TLC procedure. The data indicate that APT102 has a fast onset of action and a prolonged duration of action. This will be advantageous clinically since a bolus injection will suffice without a requirement for continuous infusion. The pharmacodynamics of APT102 were determined using ex vivo platelet aggregation to ADP, and showed identical properties. In keeping with the demonstrated lack in mice of a direct anti-platelet effect of soluble apyrase, the rat tail bleeding time was minimally prolonged in parallel experiments. Thus, APT102 strongly inhibits the recruitment of platelets into an evolving occlusive thrombus, but it is anticipated to be safer than currently employed antithrombotics since they all have a narrow therapeutic window between therapeutic effectiveness and undesirable side effects. In separate experiments involving experimental stroke, male Wistar rats were randomly infused via the tail vein with either saline or 0.75 mg APT102 per kg body weight prior to being subjected to temporary middle cerebral artery occlusion. Brain infarct volumes were determined 24 h following stroke induction. Treatment with APT102 resulted in a 40% reduction in brain infarct volume. We conclude that APT102 will represent a new therapeutic modality for platelet-driven thrombotic disorders, which appears to be safe and effective.
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Soper, Devin. "On passing an open access policy at Florida State University: From outreach to implementation." College & Research Libraries News 78, no. 8 (2017): 432. http://dx.doi.org/10.5860/crln.78.8.432.
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In February 2016, the Florida State University (FSU) Faculty Senate passed an institutional Open Access (OA) Policy by unanimous vote,1 following the lead of many public and private universities across the United States. This was the culmination of many years of outreach and advocacy by OA champions at FSU, with a diverse, talented team of faculty and librarians making significant contributions along the way. This was also just one instance of a growing trend across North America and globally, with impressive growth in the number of OA policies and mandates adopted by research organizations and funders over the past decade. The adoption of an OA policy still presents many challenges with respect to policy compliance,2 and there are open questions about the long-term impact of different OA policy requirements and implementation models.3 At the same time, OA policy adoption remains an important goal for many institutions, a symbolic affirmation of faculty support for the principles of OA. An OA policy can help an institution raise the profile of its institutional repository (IR), invigorate outreach efforts and content recruitment, and, in the case of Harvard Model policies, safeguard the author rights of its faculty.4
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Bafna, Prafulla, Shailaja Shirwaikar, and Dhanya Pramod. "Task recommender system using semantic clustering to identify the right personnel." VINE Journal of Information and Knowledge Management Systems 49, no. 2 (2019): 181–99. http://dx.doi.org/10.1108/vjikms-08-2018-0068.
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Purpose Text mining is growing in importance proportionate to the growth of unstructured data and its applications are increasing day by day from knowledge management to social media analysis. Mapping skillset of a candidate and requirements of job profile is crucial for conducting new recruitment as well as for performing internal task allocation in the organization. The automation in the process of selecting the candidates is essential to avoid bias or subjectivity, which may occur while shuffling through thousands of resumes and other informative documents. The system takes skillset in the form of documents to build the semantic space and then takes appraisals or resumes as input and suggests the persons appropriate to complete a task or job position and employees needing additional training. The purpose of this study is to extend the term-document matrix and achieve refined clusters to produce an improved recommendation. The study also focuses on achieving consistency in cluster quality in spite of increasing size of data set, to solve scalability issues. Design/methodology/approach In this study, a synset-based document matrix construction method is proposed where semantically similar terms are grouped to reduce the dimension curse. An automated Task Recommendation System is proposed comprising synset-based feature extraction, iterative semantic clustering and mapping based on semantic similarity. Findings The first step in knowledge extraction from the unstructured textual data is converting it into structured form either as Term frequency–Inverse document frequency (TF-IDF) matrix or synset-based TF-IDF. Once in structured form, a range of mining algorithms from classification to clustering can be applied. The algorithm gives a better feature vector representation and improved cluster quality. The synset-based grouping and feature extraction for resume data optimizes the candidate selection process by reducing entropy and error and by improving precision and scalability. Research limitations/implications The productivity of any organization gets enhanced by assigning tasks to employees with a right set of skills. Efficient recruitment and task allocation can not only improve productivity but also cater to satisfy employee aspiration and identifying training requirements. Practical implications Industries can use the approach to support different processes related to human resource management such as promotions, recruitment and training and, thus, manage the talent pool. Social implications The task recommender system creates knowledge by following the steps of the knowledge management cycle and this methodology can be adopted in other similar knowledge management applications. Originality/value The efficacy of the proposed approach and its enhancement is validated by carrying out experiments on the benchmarked dataset of resumes. The results are compared with existing techniques and show refined clusters. That is Absolute error is reduced by 30 per cent, precision is increased by 20 per cent and dimensions are lowered by 60 per cent than existing technique. Also, the proposed approach solves issue of scalability by producing improved recommendation for 1,000 resumes with reduced entropy.
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Jones, C., and C. Smythe. "Activation of the Xenopus cyclin degradation machinery by full-length cyclin A." Journal of Cell Science 109, no. 5 (1996): 1071–79. http://dx.doi.org/10.1242/jcs.109.5.1071.
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The entry into mitosis is dependent on the activation of mitotic forms of cdc2 kinase. In many cell types, cyclin A-associated kinase activity peaks just prior to that of cyclin B, although the precise role of cyclin A-associated kinase in the entry into mitosis is still unclear. Previous work has suggested that while cyclin B is capable of triggering cyclin destruction in Xenopus cell-free systems, cyclin A-associated kinase is not able to support this function. Here we have expressed a full-length human cyclin A in Escherichia coli and purified the protein to homogeneity by virtue of an N-terminal histidine tag. We have found that when added to Xenopus cell-free extracts free of cyclin B and incapable of protein synthesis, the temporal pattern of cyclin A-associated cdc2 kinase activity showed distinct differences that were dependent on the concentration of cyclin A added. When cyclin A was added to a concentration that generated levels of cdc2 kinase activity capable of inducing nuclear envelope breakdown, the histone H1 kinase activity profile was bi-phasic, consisting of an activation phase followed by an inactivation phase. Inactivation was found to be due to cyclin destruction, which was prevented by mos protein. Cyclin destruction was followed by nuclear reassembly and an additional round of DNA replication, indicating that there is no protein synthesis requirement for DNA replication in this embryonic system. It has been suggested that the evolutionary recruitment of cyclin A into an S phase function may have necessitated the loss of an original mitotic ability to activate the cyclin destruction pathway. The results presented here indicate that cyclin A has not lost the ability to activate its own destruction and that cyclin A-mediated activation of the cyclin destruction pathway permitted destruction of cyclin B1 as well as cyclin A, indicating that there are not distinct cyclin A and cyclin B destruction pathways. Thus the ordered progression of the cell cycle requires the careful titration of cyclin. A concentration in order to avoid activation of the cyclin destruction pathway before sufficient active cyclin B/cdc2 kinase has accumulated.
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CHEUNG, W. N. "Gain requirement profile ofLCoscillators." International Journal of Electronics 59, no. 5 (1985): 629–36. http://dx.doi.org/10.1080/00207218508920739.
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Pepperell, R. J. "Profile and recruitment in Australasia." Best Practice & Research Clinical Obstetrics & Gynaecology 13, no. 3 (1999): 371–81. http://dx.doi.org/10.1053/beog.1999.0033.
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Bygdeman, Marc. "Profile of recruitment in Sweden." Best Practice & Research Clinical Obstetrics & Gynaecology 13, no. 3 (1999): 383–92. http://dx.doi.org/10.1053/beog.1999.0034.
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Sen, Anando, Andrew Goldstein, Shreya Chakrabarti, et al. "The representativeness of eligible patients in type 2 diabetes trials: a case study using GIST 2.0." Journal of the American Medical Informatics Association 25, no. 3 (2017): 239–47. http://dx.doi.org/10.1093/jamia/ocx091.
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Abstract Objective The population representativeness of a clinical study is influenced by how real-world patients qualify for the study. We analyze the representativeness of eligible patients for multiple type 2 diabetes trials and the relationship between representativeness and other trial characteristics. Methods Sixty-nine study traits available in the electronic health record data for 2034 patients with type 2 diabetes were used to profile the target patients for type 2 diabetes trials. A set of 1691 type 2 diabetes trials was identified from ClinicalTrials.gov, and their population representativeness was calculated using the published Generalizability Index of Study Traits 2.0 metric. The relationships between population representativeness and number of traits and between trial duration and trial metadata were statistically analyzed. A focused analysis with only phase 2 and 3 interventional trials was also conducted. Results A total of 869 of 1691 trials (51.4%) and 412 of 776 phase 2 and 3 interventional trials (53.1%) had a population representativeness of <5%. The overall representativeness was significantly correlated with the representativeness of the Hba1c criterion. The greater the number of criteria or the shorter the trial, the less the representativeness. Among the trial metadata, phase, recruitment status, and start year were found to have a statistically significant effect on population representativeness. For phase 2 and 3 interventional trials, only start year was significantly associated with representativeness. Conclusions Our study quantified the representativeness of multiple type 2 diabetes trials. The common low representativeness of type 2 diabetes trials could be attributed to specific study design requirements of trials or safety concerns. Rather than criticizing the low representativeness, we contribute a method for increasing the transparency of the representativeness of clinical trials.
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Yates, Helen, Virginia Chiocchia, Louise Linsell, et al. "Very low-dose dexamethasone to facilitate extubation of preterm babies at risk of bronchopulmonary dysplasia: the MINIDEX feasibility RCT." Efficacy and Mechanism Evaluation 6, no. 8 (2019): 1–52. http://dx.doi.org/10.3310/eme06080.
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Background Postnatal corticosteroids are used to improve lung function and reduce the incidence of bronchopulmonary dysplasia (BPD) in preterm babies. However, corticosteroids may be associated with adverse neurodevelopment. Despite a lack of evidence, some clinicians in the UK use very low-dose regimens of dexamethasone hoping for positive pulmonary effects and optimal neurodevelopment. Objectives To assess the efficacy and safety of very low-dose dexamethasone at facilitating the extubation of ventilator-dependent preterm babies born at < 30 weeks’ gestation and who are at high risk of developing BPD. Design A multicentre, randomised, masked, parallel-group, placebo-controlled Phase 2b trial. The trial was designed as a feasibility study for a subsequent trial of clinical effectiveness. Setting The study was set in 11 tertiary neonatal units in the UK. Participants Ventilator-dependent preterm babies born at < 30 weeks’ gestation aged 10–21 days, receiving at least 30% inspired oxygen and at high risk of developing BPD. Exclusions were babies who had received previous courses of postnatal steroids for respiratory disease; had a severe congenital anomaly affecting the lungs, heart or central nervous system, or had a surgical abdominal procedure or patent ductus arteriosus ligation; and had an illness or medication for which postnatal corticosteroid would be contraindicated (e.g. confirmed or suspected acute sepsis, acute necrotising enterocolitis/focal intestinal perforation or cyclo-oxygenase therapy). Interventions Babies were randomised to very low-dose dexamethasone (50 µg/kg/day for 13 doses) or a matched placebo. Samples of blood and bronchoalveolar lavage fluid from a subset of babies randomised at three participating sites were sent for cytokine analysis at randomisation and at days 5, 7, 10 and 14 of treatment. Primary outcome Time to extubation. Secondary outcomes Secondary outcomes included rates of extubation by day 7 of the intervention; survival to 36 weeks’ postmenstrual age (PMA) or discharge home; respiratory morbidity to 36 weeks’ PMA or discharge home; cytokine profile; safety outcomes; and parent/family experience. Results The main metric of feasibility, namely recruitment, proved difficult. There was a tendency for open-label medication and a higher than predicted rate of suspected/confirmed sepsis among babies. Recruitment was halted after 22 babies had been enrolled. It was found that, compared with the placebo group, a higher proportion of babies were extubated at day 7 of life [5/8 (62.5%) in the very low-dose dexamethasone group vs. 2/6 (33.3%) in the placebo group] and duration of invasive ventilation was lower (a median of 23 days for the very low-dose dexamethasone group vs. a median of 31 days for the placebo group) in the very low-dose dexamethasone group. This is supported by a trend for an increased requirement for open-label rescue steroids in control group babies (41.7% in the very low-dose dexamethasone group vs. 80% in the placebo group). Given the limited sample size, only descriptive statistics can be given; firm conclusions cannot be drawn. Limitations Small sample size and high rates of open-label treatment use. Conclusions It is not feasible to conduct the required pragmatic trial of clinical effectiveness. Future work Assessment of very low-dose dexamethasone in this patient group requires careful consideration. Study registration Clinical Controlled Trials ISRCTN81191607. Funding This project was funded by the Efficacy and Mechanism Evaluation (EME) programme, a Medical Research Council and National Institute for Health Research (NIHR) partnership. The report will be published in full in Efficacy and Mechanism; Vol. 6, No. 8. See the NIHR Journals Library website for further project information. The funding for the cytokine analysis is provided by the Children’s Charity Cerebra and is being carried out beyond the lifespan of the NIHR funding.
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Brockington, Ian F., and David B. Mumford. "Recruitment into psychiatry." British Journal of Psychiatry 180, no. 4 (2002): 307–12. http://dx.doi.org/10.1192/bjp.180.4.307.
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BackgroundDespite improvements in psychiatric teaching, British medical schools have never produced enough graduands aiming for psychiatry.AimsTo inform the strategy for improving recruitment.MethodA literature review.ResultsThe number of psychiatrists required depends on the role of psychiatry, which is constantly changing. The present requirement is about 250–300 per year, including replacements and new posts. The number of psychiatric trainees has always been higher than expected from the career plans of newly qualified doctors, but the number of British graduates passing the Royal College of Psychiatrists' Membership examination has still fallen short, requiring a supplement of foreign medical graduates. The recent 50% expansion in medical students may make this country self-sufficient.ConclusionsTo improve recruitment, the College should focus on influences before and after undergraduate training – the kind of student entering medical school and the factors favouring sustained psychiatric practice after graduation.
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Schalke, Esther, Alexandra Knipf, Stefanie Ott, and Hansjoachim Hackbarth. "Requirement profile for police interview assistance dogs." Journal of Veterinary Behavior 4, no. 2 (2009): 86–87. http://dx.doi.org/10.1016/j.jveb.2008.10.007.
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Hery, Hery, Raphael Christopher, Andree E. Widjaja, and Suryasari Suryasari. "Pengembangan Aplikasi Manajemen Rekrutmen Karyawan Menggunakan Metode Profile Matching." INTENSIF: Jurnal Ilmiah Penelitian dan Penerapan Teknologi Sistem Informasi 3, no. 1 (2019): 81. http://dx.doi.org/10.29407/intensif.v3i1.12588.
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Human Resources (HR) is one of the important aspects in the company, because it will manage many aspects such as technology, resources, and capital, therefore the process of hiring and allocating training is important in the company. Human Resource Departement (HRD) is responsible for recruiting new employees and developing training programs to equip employees or prospective employees. The Recruitment process consist of three steps: CV gathering, psychotest work, and interview). In PT. XYZ recruitment process is done manually,Therefore an application is required that can support the decision-making process in the employee recruitment process that can analyze the appropriate training for prospective employees. Employee recruitment applications development and allocation of employee training using the System Development Life Cycle (SDLC) system development methodology. For employee training allocation system with profile matching method. The Final result from this research is an application that could support HRD in recruitment process and training allocation.
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Lau, Trevor, Shailesh Kumar, Trevor Lau, Shailesh Kumar, and Elizabeth Robinson. "New Zealand's Psychiatrist Workforce: Profile, Recruitment and Retention." Australian & New Zealand Journal of Psychiatry 38, no. 7 (2004): 547–53. http://dx.doi.org/10.1080/j.1440-1614.2004.01408.x.
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Byrum, C. Stephen, and Michael Harrington. "Using the Hartman Value Profile in Residence Recruitment." Plastic and Reconstructive Surgery - Global Open 4, no. 6 (2016): e769. http://dx.doi.org/10.1097/gox.0000000000000787.
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Sunarti, Rahmadian Y. Rangga, and Yulvia Nora Marlim. "Application Profile Matching Method for Employees Online Recruitment." IOP Conference Series: Earth and Environmental Science 97 (December 2017): 012035. http://dx.doi.org/10.1088/1755-1315/97/1/012035.
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Fang, Feng, and Shi Gui Li. "Research of Optimization Methods in Recruitment." Applied Mechanics and Materials 121-126 (October 2011): 4581–85. http://dx.doi.org/10.4028/www.scientific.net/amm.121-126.4581.
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In various business unit of recruitment enrollment,how to quantization admitted as compliance with a post requirement of applicants, as well as possible personnel employed skills and potential, to create greater efficiency, is faced with various business unit in front of an important issue. Therefore, a thinking method and mathematical model of recruitment admission scheme is put forward using a concrete example, hoping for dealing with such practical problems help and enlightenment.
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Masys, Anthony J. "Radicalization and Recruitment." International Journal of Systems and Society 1, no. 2 (2014): 51–65. http://dx.doi.org/10.4018/ijss.2014070104.
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Recent events such as the terrorist attack in Algeria (January 2013), the Boston Marathon Bombing (April 2013), the apprehension of two suspected al-Qaeda linked terrorists in Toronto, (April 2013), highlight the requirement for greater understanding regarding the radicalization and recruitment of terrorists. As detailed in the US Department of State Report (2011), over 10,000 terrorist attacks occurred in 2011, affecting nearly 45,000 victims in 70 countries and resulting in over 12,500 deaths. With a focus on the outcomes and results of terrorist activities, terrorism itself often becomes a ‘blackbox' concept that does not capture the essence of the radicalization process nor the mechanisms of recruitment. This conceptual paper introduces Actor Network Theory (ANT) as a systems lens to open the ‘blackbox' of terrorism. This systems lens ‘…is a discipline for seeing wholes. It is a framework for seeing interrelationships rather than things, for seeing patterns of change rather than static snapshots' (Senge, 1990:68). The systems view facilitated by ANT is supported and informed by methods of network analysis and conceptual modelling that highlight how dynamic networked actors shape the radicalization process through the actor network process of translation.
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Aniss, Qostal, Moumen Aniss, and Lakhrissi Younes. "The role of social networks in personality analysis for recruitment of laureates: A systematic review and exploratory study." SHS Web of Conferences 119 (2021): 05004. http://dx.doi.org/10.1051/shsconf/202111905004.
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Today, the recruitment process has seen a drastic change in the measure of the personality aspect of the candidates. Accordingly, in the era of digitalization and the proliferation of the professional social network, the selection of valuable information provided from the candidate’s accounts has a primordial role in the selection of the profiles responding to job offers and to create a global vision on the personality and the capability of the job seekers from teamwork and leadership to meet the job requirements. The paper aims to discover the approaches applied in the personality analysis based on the professional networks. Beginning with a systematic review of previous works and exploratory analysis through interviews with stakeholders participated in the recruitment process.
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Mardi, Dedi Liyus. "Penerapan Metode Profile Matching Pada Perekrutan Karyawan untuk PT. Dinasti Motekar Group." Ultima InfoSys : Jurnal Ilmu Sistem Informasi 12, no. 1 (2021): 8–20. http://dx.doi.org/10.31937/si.v12i1.1547.
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Human resources are particularly important factor in any corporation to support the successful corporation. Employee recruitment is a thing that is not separated from a human resources management activity. To have employee fit expectation of corporation, the right employee recruitment system is necessary to have employee in accordance with his or her expertise. In the process of employee recruitment, a supporting decision system is required. Method used to make the employee recruitment system is using Profile Matching. In this study is raised a cases; i.e. seeking for the best alternative for the recruitment of employee in PT. Dinasti Motekar Group. The Profile Matching was chosen as it can establish weight grade for each attribute, then it is continued by the ranking process to be able to select the best alternative from other alternatives. The best alternative, therefore, might be acquired based on specific criteria as they were established by the corporation.
 Index Terms—Employee Recruitment; Decision Support System; Profile Matching.
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Braz Pereira Gomes, Eduardo, Juliana Luíza Moreira Del Fiaco, and Aline Araújo Rabelo. "ANÁLISE DE PROCEDIMENTOS DE SELEÇÃO DE PESSOAL; ANALYSIS OF PERSONNEL SELECTION PROCEDURES." Revista Gestão, Inovação e Negócios 3, no. 1 (2017): 22. http://dx.doi.org/10.29246/2358-9868.2017v3i1.p22-42.
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RESUMOO recrutamento e seleção é o primeiro subsistema da área de recursos humanos, com a função de selecionar os candidatos que apresentam perfil adequado para atender as exigências das organizações. Para realizar esses procedimentos, os selecionadores utilizam de algumas táticas para tornar o processo mais assertivo e eficaz. Este artigo tem o objetivo de analisar os procedimentos que uma empresa de consultoria utiliza para recrutar e selecionar candidatos para os mais variados ramos de atividades. Por meio do estudo de caso realizado na Ampliar Assessoria em Desenvolvimento Humano foi possível entender como a área de gestão de pessoas trabalha ao recrutar e selecionar, bem como descrever as técnicas utilizadas para desenvolver este processo, sendo observada nos procedimentos utilizados, triagem de currículos, entrevistas, testes psicológicos, dinâmica de grupo e provas de conhecimentos quando o contratante solicita. O resultado da pesquisa abordou também, um problema que a Ampliar enfrentou em uma das etapas do processo e propõe melhorias para que se obtenha sucesso ao realizar os procedimentos e garantir a fidelidade de seus clientes.Palavras-Chave: Recrutamento; Seleção; Procedimentos; Recursos Humanos; Gestão de Pessoas.ABSTRACTRecruitment and selection is the first human resources subsystem, with the function of selecting candidates who present appropriate profile to meet the requirements of organizations. To perform these procedures, the selectors use of some tactics to make the process more assertive and effective. This article aims to analyze the procedures that a Consulting company uses to recruit and select nominees for the various branches of activities. Through the case study in Ampliar Assessoria em Desenvolvimento Humano. It was possible to understand how the area of people management works to recruited select, as well as describe the techniques used to develop this process, being observed in the procedures used, screening resumes, interviews, psychological tests, group dynamics and evidence of knowledge when the contractor requests. The result of the survey also addressed a problem that Ampliar faced in one of the stages of the process and propose improvements to obtain success when performing the procedures and ensure the fidelity of its customers.Keywords: Recruitment; Selection; Procedures; Human Resources; People management.
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Higgins, C. Steven, Elizabeth M. Hawthorne, Jane A. Cape, and Laurie Bell. "The Successful Community College Instructor: A Profile for Recruitment." Community College Review 21, no. 4 (1994): 27–36. http://dx.doi.org/10.1177/009155219402100404.
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Wang, Gang, Michael A. Balamotis, Jennitte L. Stevens, Yuki Yamaguchi, Hiroshi Handa, and Arnold J. Berk. "Mediator Requirement for Both Recruitment and Postrecruitment Steps in Transcription Initiation." Molecular Cell 17, no. 5 (2005): 683–94. http://dx.doi.org/10.1016/j.molcel.2005.02.010.
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Kuzmina, E. Yu, and I. V. Soklakova. "OUTSOURCING AS AN EFFECTIVE FORM OF RECRUITMENT." Scientific Journal ECONOMIC SYSTEMS 13, no. 2 (2020): 111–18. http://dx.doi.org/10.29030/2309-2076-2020-13-2-111-118.
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This article discusses the possibilities of using modern organization outsourcing in the field of HR. The article analyzes the company’s ability to attract temporary specialists. The example of a production company shows the influence of various factors on the recruitment of personnel, such as seasonal demand, the actions of competitors, the needs of the company itself in specialists of different profiles. The advantages and disadvantages of using outsourcing are highlighted. The effectiveness of outsourcing practices in hiring staff is proved. It is emphasized that such important goals of outsourcing are achieved as improving the quality of goods and services, increasing the financial stability of the enterprise while maintaining its core activities. Self-employment creates additional risks associated with non-compliance with professional qualifications, lack of necessary experience, and unfair performance of official duties. The comparison of budgets for self-employment and outsourcing, which take into account the additional costs of finding and hiring temporary employees, as well as their training, concludes that it is profitable to attract temporary employees, if it is possible to conclude an outsourcing contract. But in terms of reducing costs and oversupply of the labor market, it is possible to hire on their own, since this does not require additional training of temporary staff, the salary Fund and payments to the budget will decrease, and the lack of requirements for high qualification of the necessary workers will significantly simplify their search and hiring.
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Kim, Nancy D., Richard C. Chou, Edward Seung, Andrew M. Tager, and Andrew D. Luster. "A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis." Journal of Experimental Medicine 203, no. 4 (2006): 829–35. http://dx.doi.org/10.1084/jem.20052349.
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Neutrophil recruitment into tissue plays an important role in host defense and disease pathogenesis, including the inflammatory arthritides. A multitude of diverse chemoattractants have been implicated in neutrophil recruitment, suggesting that they have overlapping functions in mediating this critical biological response. However, here we demonstrate a unique, non-redundant role for the leukotriene B4 receptor BLT1 in mediating neutrophil recruitment into the joint in the K/BxN mouse model of inflammatory arthritis. We demonstrate that neutrophil expression of BLT1 was absolutely required for arthritis generation and chemokine production in this model, and that specific BLT1 inhibition reversed established disease. Adoptive transfer of wild-type (WT) neutrophils restored arthritis and chemokine production in BLT1−/− mice. Surprisingly, the primary effect of the transferred WT neutrophils into BLT1−/− mice was to promote the entry of endogenous BLT1−/− neutrophils into the joints of these mice. However, continued joint inflammation was dependent on the presence of WT neutrophils, indicating an ongoing specific requirement for BLT1-activated neutrophils in mediating BLT1−/− neutrophil recruitment by other chemoattractants. These experiments demonstrate that neutrophil BLT1 functions in a novel and essential non–cell-autonomous manner to enable the recruitment of additional neutrophils not expressing this receptor, thereby amplifying the inflammatory response in autoantibody-induced arthritis.
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Koga, Shunsaku, David C. Poole, Tomoyuki Shiojiri, et al. "Comparison of oxygen uptake kinetics during knee extension and cycle exercise." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 1 (2005): R212—R220. http://dx.doi.org/10.1152/ajpregu.00147.2004.
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The knee extension exercise (KE) model engenders different muscle and fiber recruitment patterns, blood flow, and energetic responses compared with conventional cycle ergometry (CE). This investigation had two aims: 1) to test the hypothesis that upright two-leg KE and CE in the same subjects would yield fundamentally different pulmonary O2 uptake (pV̇o2) kinetics and 2) to characterize the muscle blood flow, muscle V̇o2 (mV̇o2), and pV̇o2 kinetics during KE to investigate the rate-limiting factor(s) of pV̇o2 on kinetics and muscle energetics and their mechanistic bases after the onset of heavy exercise. Six subjects performed KE and CE transitions from unloaded to moderate [< ventilatory threshold (VT)] and heavy (>VT) exercise. In addition to pV̇o2 during CE and KE, simultaneous pulsed and echo Doppler methods, combined with blood sampling from the femoral vein, were used to quantify the precise temporal profiles of femoral artery blood flow (LBF) and mV̇o2 at the onset of KE. First, the gain (amplitude/work rate) of the primary component of pV̇o2 for both moderate and heavy exercise was higher during KE (∼12 ml·W−1·min−1) compared with CE (∼10), but the time constants for the primary component did not differ. Furthermore, the mean response time (MRT) and the contribution of the slow component to the overall response for heavy KE were significantly greater than for CE. Second, the time constant for the primary component of mV̇o2 during heavy KE [25.8 ± 9.0 s (SD)] was not significantly different from that of the phase II pV̇o2. Moreover, the slow component of pV̇o2 evident for the heavy KE reflected the gradual increase in mV̇o2. The initial LBF kinetics after onset of KE were significantly faster than the phase II pV̇o2 kinetics (moderate: time constant LBF = 8.0 ± 3.5 s, pV̇o2 = 32.7 ± 5.6 s, P < 0.05; heavy: LBF = 9.7 ± 2.0 s, pV̇o2 = 29.9 ± 7.9 s, P < 0.05). The MRT of LBF was also significantly faster than that of pV̇o2. These data demonstrate that the energetics (as gain) for KE are greater than for CE, but the kinetics of adjustment (as time constant for the primary component) are similar. Furthermore, the kinetics of muscle blood flow during KE are faster than those of pV̇o2, consistent with an intramuscular limitation to V̇o2 kinetics, i.e., a microvascular O2 delivery-to-O2 requirement mismatch or oxidative enzyme inertia.
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Singer, Julian, Yan Jun Li, Tracey Ying, et al. "Protocol for a pilot single-centre, parallel-arm, randomised controlled trial of dietary inulin to improve gut health in solid organ transplantation: the DIGEST study." BMJ Open 11, no. 4 (2021): e049184. http://dx.doi.org/10.1136/bmjopen-2021-049184.
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IntroductionKidney transplantation remains the best treatment for end-stage kidney disease, however the requirement for indefinite immunosuppression increases the risk of cardiovascular disease, cancer and infection, leading to a reduction in long-term patient and graft survival. The gut microbiome is a critical determinant of health and modulates host immunity and metabolism through a number of recognised pathways, including through the production of immunomodulatory short-chain fatty acids (SCFA). Dietary supplementation with non-digestible fibre can augment the microbial production of SCFA and lead to favourable immune and metabolic outcomes, although this has yet to be shown in human kidney transplant recipients.Methods and analysisDietary inulin for gut health in solid-organ transplantation (DIGEST) is a single-centre, unblinded, pilot parallel-arm randomised controlled trial designed to assess the feasibility and adherence of dietary inulin, a naturally occurring dietary fibre, in the early post-transplant period in kidney transplant recipients. Participants will be randomised at day 28 post-transplant to a 4-week period of dietary inulin (10–20 g/day) in addition to standard care, or standard care alone, and followed-up until week 12 post-transplant.The primary outcomes of the study are: (i) the feasibility of participant recruitment, randomisation and retention; (ii) adherence to the intervention (inulin) and (iii) the tolerability of inulin determined by changes in gastrointestinal symptoms as scored on the Gastrointestinal Symptom Rating Scale.Secondary outcomes include: (1) glycaemic variability determined by continuous glucose monitoring; (2) abundance of SCFA-producing microbiota, as determined by 16s rRNA sequencing of the faecal metagenome; (3) serum SCFA concentrations; (4) peripheral blood immune cell populations; (5) recipient inflammatory and metabolic profiles and (6) the incidence of biopsy-proven acute rejection and kidney function determined by estimated glomerular filtration rate.Ethics and disseminationAll study visits, clinical and laboratory assessments will be integrated into usual post-transplant care, creating no additional healthcare encounters or procedures. The risks associated with this study are minor. Inulin has been shown to be well tolerated across a variety of cohorts, with the occurrence of short-term adverse gastrointestinal symptoms self-limiting. However, with gastrointestinal adverse events common following kidney transplantation, the tolerability of inulin in this cohort remains unknown. The results of DIGEST will be published in peer-reviewed journals and presented at academic conferences. This study has been approved by the Sydney Local Health District’s Ethics Committee (Royal Prince Alfred Hospital Zone).Trial registration numberACTRN12620000623998.
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Kollitz, Rouven, Sascha Ruhle, and Stefan Süß. "Recruitment practices under scrutiny: A latent-profile analysis of family firms’ approaches to recruit non-family employees." German Journal of Human Resource Management: Zeitschrift für Personalforschung 33, no. 3 (2019): 167–96. http://dx.doi.org/10.1177/2397002219831502.
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Recruitment of qualified non-family employees is a challenge for many family firms. Job seekers from outside may be wary of the family firm employment practice and the family themselves may have an informal approach to finding employees which often relies on word of mouth and produces a limited pool of talent. In this study we investigate adopted recruitment practices and the factors behind recruiting non-family workforce as we seek common elements, explanations and outcomes. Applying latent-profile analysis to the recruiting practices of 259 family firms we explore sets of adopted recruitment practices, their respective predictors, including socioemotional wealth, and potential outcomes. These analyses reveal five latent classes: (1) reduced recruitment; (2) online high cost recruitment; (3) full scope recruitment; (4) offline informal recruitment; and (5) formal high cost recruitment. In sum, our findings suggest that substantial differences in family firms’ approaches to recruitment exist, providing further evidence for the heterogeneity of family firms. Finally, findings are discussed with regard to limitations and implications for future research.
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Tessema, Mussie T., Kiflemariam Abraham, Jing Han, Madison Bowe, and Tayler Bug. "Technology-Based Recruitment and Selection Approaches of an American Multinational Company (AMNC): Practical Implications." International Journal of Human Resource Studies 10, no. 3 (2020): 117. http://dx.doi.org/10.5296/ijhrs.v10i3.17082.
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This study identifies and discusses six technologies that affect recruitment and selection approaches using an American multinational company (AMNC) as a case study. It indicates that technology-based recruitment and selection approaches have had a noticeable impact on the AMNC’s recruitment and selection processes and practices in general, and the three stakeholders (human resource- HR- managers, hiring managers, and job-applicants) in particular. It concludes that the use of technology-based recruitment and selection approaches is not the matter of choice but is a requirement for the success of any company. It also offers the study’s implications and future research directions.
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Amick, Joseph, Arun Kumar Tharkeshwar, Catherine Amaya,, and Shawn M. Ferguson. "WDR41 supports lysosomal response to changes in amino acid availability." Molecular Biology of the Cell 29, no. 18 (2018): 2213–27. http://dx.doi.org/10.1091/mbc.e17-12-0703.
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C9orf72 mutations are a major cause of amyotrophic lateral sclerosis and frontotemporal dementia. The C9orf72 protein undergoes regulated recruitment to lysosomes and has been broadly implicated in control of lysosome homeostasis. However, although evidence strongly supports an important function for C9orf72 at lysosomes, little is known about the lysosome recruitment mechanism. In this study, we identify an essential role for WDR41, a prominent C9orf72 interacting protein, in C9orf72 lysosome recruitment. Analysis of human WDR41 knockout cells revealed that WDR41 is required for localization of the protein complex containing C9orf72 and SMCR8 to lysosomes. Such lysosome localization increases in response to amino acid starvation but is not dependent on either mTORC1 inhibition or autophagy induction. Furthermore, WDR41 itself exhibits a parallel pattern of regulated association with lysosomes. This WDR41-dependent recruitment of C9orf72 to lysosomes is critical for the ability of lysosomes to support mTORC1 signaling as constitutive targeting of C9orf72 to lysosomes relieves the requirement for WDR41 in mTORC1 activation. Collectively, this study reveals an essential role for WDR41 in supporting the regulated binding of C9orf72 to lysosomes and solidifies the requirement for a larger C9orf72 containing protein complex in coordinating lysosomal responses to changes in amino acid availability.
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Kurup, S., A. Abramsson, J. P. Li, et al. "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment." Biochemical Society Transactions 34, no. 3 (2006): 454–55. http://dx.doi.org/10.1042/bst0340454.
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HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. It has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulatory process.
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van Oevelen, Chris J. C., Hetty A. A. M. van Teeffelen, and H. T. Marc Timmers. "Differential Requirement of SAGA Subunits for Mot1p and Taf1p Recruitment in Gene Activation." Molecular and Cellular Biology 25, no. 12 (2005): 4863–72. http://dx.doi.org/10.1128/mcb.25.12.4863-4872.2005.
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ABSTRACT Transcription activation in yeast (Saccharomyces cerevisiae) involves ordered recruitment of transcription factor complexes, such as TFIID, SAGA, and Mot1p. Previously, we showed that both Mot1p and Taf1p are recruited to the HXT2 and HXT4 genes, which encode hexose transporter proteins. Here, we show that SAGA also binds to the HXT2 and HXT4 promoters and plays a pivotal role in the recruitment of Mot1p and Taf1p. The deletion of either SPT3 or SPT8 reduces Mot1p binding to HXT2 and HXT4. Surprisingly, the deletion of GCN5 reduces Taf1p binding to both promoters. When GCN5 is deleted in spt3Δ or spt8Δ strains, neither Mot1p nor Taf1p binds, and this results in a diminished recruitment of TATA binding protein and polymerase II to the HXT4 but not the HXT2 promoter. This is reflected by the SAGA-dependent expression of HXT4. In contrast, SAGA-independent induction of HXT2 suggests a functional redundancy with other factors. A functional interplay of different SAGA subunits with Mot1p and Taf1p was supported by phenotypic analysis of MOT1 SAGA or TAF1/SAGA double mutant strains, which revealed novel genetic interactions between MOT1 and SPT8 and between TAF1 and GCN5. In conclusion, our data demonstrate functional links between SAGA, Mot1p, and TFIID in HXT gene regulation.
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D. G., Amusan, and Oyediran M. O. "Development of Efficient E-Recruitment System for University Staff in Nigeria." Circulation in Computer Science 1, no. 1 (2016): 10–14. http://dx.doi.org/10.22632/ccs-2016-251-13.
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The development of e-recruitment system is web-based tool used in order to reduce communication gap between job seekers and employers. E-recruitment, also known as online recruitment, is the practice of using technology and in particular Web-based resources for tasks involved with finding, attracting, assessing, interviewing and hiring new personnel. Most of the existing mode of recruitment (manual recruitment) takes much time in processing the application form, existing system will not automatically send feedback to all applicant whose meet up with the job requirement but with the help of the developed system there is reduction in time to process the application form and there is automatic feedback from the employer to the job seeker that meet up with requirement. The objective of this work is to developed an efficient e-recruitment system capable of managing all stages of the e- recruitment process, including multi-job posting, agency channel management and candidate filtering to identify the most relevant candidates. The development e-recruitment system employs 3-tier web architecture. The system consisted of design activities that produce system specifications satisfying the functional requirements that were developed in the system analysis process. A Unified Modeling Language (UML) was used to build a formal model of the university recruitment system. The Web-based University Recruitment System (WBURS) was designed to be user friendly and it is easy to navigate. A Macromedia dream wave was used in coding and developing website; SWISHmax was also used for creating graphics and animation in developing the website. Structured Query Language (SQL) was employed in creation of the database for the website and adoption of PHP (Hypertext Processor) was adopted to connect the website to a database. The performance of the developed system was evaluated by consulting three university staff and relevant information was collated through personal interviews and questionnaires was administered to the staff of those university, Human Resource Departments and other relevant professionals of these university.
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Walewski, Jan, Ewa Paszkiewicz-Kozik, Gabriela Borsaru, et al. "Resminostat In Relapsed or Refractory Hodgkin Lymphoma: Initial Results of the SAPHIRE Phase II Trial with a Novel Oral Histone Deacetylase (HDAC) Inhibitor." Blood 116, no. 21 (2010): 2811. http://dx.doi.org/10.1182/blood.v116.21.2811.2811.
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Abstract Abstract 2811 Resminostat (4SC-201) is a novel pan-HDAC inhibitor that has shown anti-tumor activity in a broad panel of preclinical models and revealed a very favorable safety and promising efficacy profile in patients with various solid tumor types in an initial Phase I trial. Resminostat is currently under investigation in a number of Phase II clinical trials. The SAPHIRE study evaluates the therapeutic activity of resminostat in relapsed/refractory Hodgkin Lymphoma (HL) patients after high dose chemotherapy and autologous hematopoietic stem cell transplantation. The trial is designed as an open-label, single-arm international trial with a Simon Minimax design. Resminostat is administered orally at a once daily dose of 600 mg in 2-week cycles consisting of 5 consecutive days treatment followed by a 9 day treatment free period. Dose delay and reduction is allowed for management of adverse events. Patients undergo assessment of disease status by computed tomography in combination with positron emission tomography (PET/CT), as recommended by the International Working Group (IWG) criteria for the evaluation of HL. PET/CT scans are conducted after cycle 3 and cycle 6 and thereafter every 4th cycle during an optional follow-up treatment period in which patients may remain on treatment until disease progression or occurrence of intolerance to protocol therapy. The primary endpoint of the study is the estimation of overall objective response rate (OOR), secondary endpoints include time to response (TTR), duration of response (DOR), safety and tolerability and the study of drug regulated biomarkers in this patient cohort. As of July 2010, 19 patients with advanced HL have been enrolled in the 1st Simon stage of the study. Treatment was well tolerated with common related grade 2 –3 AEs being anemia and thrombocytopenia that were well manageable by dose modification or symptomatic treatment. Analysis of PET/CT data through an independent central assessment committee confirmed the achievement of the clinical activity requirements for the advancement of the trial into the 2nd Simon recruitment phase. Updated clinical data of this ongoing study on the efficacy and safety of the HDAC inhibitor resminostat in relapsed/refractory HL patients will be presented at the meeting. Disclosures: Walewski: 4SC AG: Consultancy. Warszewska:4SC AG: Consultancy. Strobel:4SC AG: Consultancy. Biggi:4SC AG: Consultancy. Hauns:4SC AG: Employment. Mais:4SC AG: Employment. Henning: 4SC AG: Employment. Hentsch:4SC AG: Employment.
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Гордеев, Александр Александрович. "МОДЕЛЬ КАЧЕСТВА ОТДЕЛЬНОГО ТРЕБОВАНИЯ ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ". RADIOELECTRONIC AND COMPUTER SYSTEMS, № 2 (26 квітня 2020): 48–58. http://dx.doi.org/10.32620/reks.2020.2.04.
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The basis of the specification for software development is the requirements profile, which takes into account functionality, features, limitations, risks, etc. of future software. The requirements profile is a product of the profiling process and is a taxonomic structure that links together many of the requirements for the software being developed. An indivisible unit of the requirements profile is a separate software requirement. Formally, the software requirement is a set of related requirements, but it is a more complex object, the quality of the software as a whole depends on its quality. The implementation of insufficient quality requirements in software entails resource losses. Existing works related to this issue do not fully propose the presentation of the quality model of a particular requirement. The purpose of this article is to develop a quality model of an individual software requirement. The object of research is the software requirement. The article is devoted to the development of a quality model of an individual software requirement. The idea of developing the designated model came about after analyzing the following standards: ISO / IEC / IEEE 29148: 2011 (E), ISO / IEC / IEEE 29148: 2018 (E) and ISO / IEC 25012: 2008. The provisions that are presented in the designated standards and formed the basis of this article. It considers the requirement as a separate, unrelated element of the software requirements profile. The requirement is represented in the form of elements of facet-hierarchical structures and consists of a semantic classification attribute and a semantic taxon. A five-component model of the quality of an individual software requirement is proposed, it includes structure, properties, attributes, syntax, and semantics requirements. The combination of such elements in one model allows us to formally describe the quality of an individual software requirement. As a result, this article proposes a formal description and presentation of the quality model of an individual software requirement.