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Journal articles on the topic 'Recurrent aphthous ulcers'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Potra-Cicalău, G. I., I. Scrobotă, G. Iova, L. Todor, G. Ciavoi, and R. C. Iurcov. "Recurrent aphthous ulcers (RAU) and recurrent aphthous stomatitis (RAS) enigmatic etiopathology." Medicine in Evolution 29, no. 2 (2023): 136–41. http://dx.doi.org/10.70921/medev.v29i2.1011.

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Oral aphthous ulcer is a well-known condition that significantly affects the quality of life for patients by producing intense pain and difficulties in speaking and chewing. When recurrence is present we refer to them as recurrent aphthous ulcers (RAU) and recurrent aphthous stomatitis (RAS). Mouth ulcers are typically uncomfortable sores that can occur as a result of a variety of local and general disorders. It is one of the most prevalent oral ulcerative conditions.

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2

Lv, Xiaoying, and Yaxiong Guo. "Research Progress on Traditional Chinese Medicine Treatment of Recurrent Oral Ulcers in Children." Journal of Contemporary Medical Practice 7, no. 1 (2025): 197–200. https://doi.org/10.53469/jcmp.2025.07(01).37.

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Objective: To analyze and discuss the treatment of recurrent oral ulcers with traditional Chinese medicine (TCM), in order to provide a reference for the treatment of recurrent oral ulcers and other related oral diseases with TCM in the future. Methods: The key words “recurrent oral ulcers in children” or “recurrent aphthous ulcers in children” and the Chinese medical names “aphthous ulcers”, “aphthous ulcers”, “mouth ulcer”, “mouth erosion”, etc., and secondary searches with “Chinese medicine”, “combination of Chinese and Western medicine”, etc. were performed. A secondary search with “Chines

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3

Vashishat, Bhart, Shruti Sinha, Tanmay Srivastava, et al. "Management of oral aphthous ulcer: A review." Bioinformation 20, no. 5 (2024): 434–38. http://dx.doi.org/10.6026/973206300200434.

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Aphthous ulcers, also known as canker sores, are a common oral condition characterized by recurrent, painful, small ulcers that typically arise on the non-keratinized mucous membranes within the mouth. Although the pathogenesis of aphthous ulcers is not completely understood; it is believed to be involved in a combination of genetic predisposition, local trauma, stress, hormonal changes, and certain environmental factors. Thus, management of aphthous ulcer revolves around reducing pain, promoting healing and preventing recurrence.

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Prathoshini, Manthra. "Management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements." Bioinformation 16, no. 12 (2020): 992–98. http://dx.doi.org/10.6026/97320630016992.

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Recurrent Aphthous ulcers are the most common oral lesions among dental patients. The ulcers, which usually occur on the nonkeratinized oral mucosa, can cause considerable pain and may interfere with eating, speaking, and swallowing. Therefore, it is of interest to report data on the management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements. Case sheets of 76 patients who underwent treatment for recurrent aphthous ulcer between June 2019 and March 2020 at the Saveetha Dental College, India were used in this analysis. Data was analyzed using Chi

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Prathoshini, Manthra. "Management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements." Bioinformation 16, no. 12 (2020): 992–98. http://dx.doi.org/10.6026/97320630016992.

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Recurrent Aphthous ulcers are the most common oral lesions among dental patients. The ulcers, which usually occur on the nonkeratinized oral mucosa, can cause considerable pain and may interfere with eating, speaking, and swallowing. Therefore, it is of interest to report data on the management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements. Case sheets of 76 patients who underwent treatment for recurrent aphthous ulcer between June 2019 and March 2020 at the Saveetha Dental College, India were used in this analysis. Data was analyzed using Chi

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6

Jin, Ying, Xiaoping Lin, Liming Song, et al. "The Effect of Pudilan Anti-Inflammatory Oral Liquid on the Treatment of Mild Recurrent Aphthous Ulcers." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/6250892.

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Recurrent aphthous ulcers are the most common recurrent oral mucosal lesions characterized by recurrence and pain. The aim of this research is to evaluate the short-term curative effect of the traditional Chinese medicine “Pudilan anti-inflammatory oral liquid” on mild recurrent aphthous ulcers. A total of 234 patients were divided into a treatment group and a control group. Both groups used vitamin B2 as the basis of treatment. The treatment group took a Pudilan anti-inflammatory oral solution for 8 days while the control group was given a liquid placebo. The ulcer size, pseudomembrane, perip

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7

Aderaye, G. "Recurrent aphthous ulcers." Tobacco Control 4, no. 4 (1995): 399–400. http://dx.doi.org/10.1136/tc.4.4.399b.

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8

Majid Al-Hamdani, Ghaith, and Layla Sabri Yas. "Serum and Salivary Ferritin Level in Relation to Iron Deficiency Patient with Recurrent Aphthous Stomatitis." Tikrit Journal for Dental Sciences 11, no. 2 (2024): 304–9. http://dx.doi.org/10.25130/tjds.11.2.16.

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Background: Rec urrent aphthous stomatitis (RAS) is one of the most widespread disorders affecting the oral mucosa, with a prevalence of 50–66%. This study investigated the serum and salivary levels of ferritin between participants with recurrent aphthous ulcers and healthy. Methods: A total of 75 individuals participated in the research separated into three groups, clinically healthy control group (n=25), iron deficiency anemi c patient with recurrent aphthous stomatitis (n=25), and iron deficiency anemic patient without recurrent aphthous stomatitis (n=25). The enzyme-linked immunosorbent as

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9

Nzhad Mustafa, Bero, and Ali Fakhree Alzubaidee. "Comparative Evaluation of The Efficacy of Topical Hyaluronic Acid ( 0.2%) and Topical Triamcinolone Acetonide( 0.1%) in The Treatment of Recurrent Aphthous Stomatitis." Diyala Journal of Medicine 19, no. 2 (2020): 107–17. http://dx.doi.org/10.26505/djm.19025470628.

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Background: Recurrent aphthous ulcers are the most common oral lesion. They are classified into minor, major, and herpetiform ulcers. More than 85% of recurrent aphthous stomatitis presents as a minor ulcer. Hyaluronic acid is a biomaterial and it is a major carbohydrate component that can be found in many tissues and recently introduced as an alternative approach to enhance wound healing. Triamcinolone acetonide is a synthetic corticosteroid and it has two forms for topical use cream (0.1%) and ointment (0.1%). Objective: To make a comparison between the effectiveness of hyaluronic acid (0.2%

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10

Al-Bayati, Sura Ali Ahmed Fuoad. "A Case Report of Major Aphthous Ulcer." International Journal of Membrane Science and Technology 10, no. 2 (2023): 3390–95. http://dx.doi.org/10.15379/ijmst.v10i2.3124.

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Recurrent aphthous ulceration (RAU) is the most common ulcerative condition following traumatic ulcer that affects the oral cavity. It has three clinical presentations, major, minor and herpitiform aphthous ulceration, all are painful and mostly occur on non-keratinized mucosa. If not secondary infected it will heal spontaneously without leaving scar. Our patient was suffering from recurrent ulcers and one single large ulcer that prevent him from swallowing. Following a comprehensive history and clinical examination, interpreting the clinical findings, the ulcers had been diagnosed as aphthous

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11

Wang, Dan. "New Progress in the Integrated Treatment of Traditional Chinese and Western Medicine for Recurrent Aphthous Ulcer in the Oral Cavity." International Journal of Public Health and Medical Research 1, no. 3 (2024): 85–87. http://dx.doi.org/10.62051/ijphmr.v1n3.12.

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Recurrent aphthous ulcer in the oral cavity is a common oral mucosal disease with periodic, recurrent, and self-limiting characteristics. This article aims to explore the new progress of integrated traditional Chinese and Western medicine in the treatment of recurrent aphthous ulcers in the oral cavity. Through a comprehensive analysis of relevant research, the advantages and mechanisms of integrated traditional Chinese and Western medicine in improving efficacy, reducing symptoms, and reducing recurrence rates are elaborated, providing reference for clinical treatment.

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12

Nagihan, Bilal. "An Assessment of the Levels of Anxiety and Depression in Patients with Recurrent Aphthous Stomatitis." Archives of Otolaryngology and Rhinology 2, no. 1 (2016): 001–5. https://doi.org/10.17352/2455-1759.000011.

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<strong>Backgrounds:</strong> There is a lack of valid and reliable studies in literature on both the distinctive and ambiguous relationship between the psychological profile and the occurrence of recurrent aphthous ulcers in the individual.  <strong>Objectives:</strong> The etiology of recurrent aphthous ulceration (RAU) is not well understood. This study analyzes the psychological treatment of patients with recurrent aphthous using valid, confidential and effective psychological measures.  <strong>Materials:</strong> In this study we included 50 patients with recurrent aphthous sto

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Susanto, Hendri, Rona Tirtaardi Dewi, and Mardiah Suci Hardianti. "Oral Aphthous-like Ulcers Response to Topical Therapy in Young Adult Woman with Beta-Thalassemia Intermedia." Journal of Indonesian Oral Medicine Society 2, no. 1 (2024): 8. http://dx.doi.org/10.32793/jioms.v2i1.1157.

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Background: Beta thalassemia may have some oral manifestations. Oral mucosa ulcer may be one of the oral manifestations of beta-thalassemia. The oral ulcer may resemble recurrent aphthous stomatitis (RAS). This current case report aims to present an aphthous oral ulcer as a manifestation in young adult women with beta-thalassemia. Case report: A 28-year-old woman complained of recurrent painful oral ulcers in the labial mucosa. She was diagnosed with beta-thalassemia intermedia three years before. The ulcer may take 3-4 weeks to heal completely. Intraoral examination revealed two yellowish ulc

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Hernawati, Sri. "Management of Recurrent Aphthous Stomatitis in a Patient with High Recurrence Frequency." Health Notions 4, no. 4 (2020): 102–8. http://dx.doi.org/10.33846/hn40401.

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RAS (Recurrent Aphthous Stomatitis) is an inflammation of soft tissues of the oral cavity characterized by recurrent and painful ulcers. These lesions can be marked early on with a burning sensation, and when the wound has formed, the pain is getting worse. Occasional symptoms of precursors, paresthesia and hyperesthesia, are sometimes reported. Pain and discomfort arise along movement around the ulcer e.g. eating, talking and swallowing. Characteristics of RAS are usually single or multiple ulcers occurring recursively on the oral mucosa, round or oval in shape, clearly demarcated, with a gra

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15

Taher, Aya K., and Nada Jafer MH Radhi. "Gingival health status in relation to salivary irisin in oral ulcerative patients of Diyala city, Iraq." Sumer 1 8, CSS 1 (2023): 1–6. http://dx.doi.org/10.21931/rb/css/s2023.08.01.11.

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Background: Gingivitis is the inflammation of the gingival tissue around the teeth initiated by bacteria. Irisin is a newly identified novel anti-inflammatory effect of adipocytokine. Recurrent aphthous ulcer (RAU) remains the most common ulcerative disease in the mucosa tissue of the oral cavity, existing as repeated onset of single or multiple painful ulcers. The study aims to evaluate gingival health status in relation to salivary irisin in oral ulcerative patients of Diyala City/ Iraq. The total sample consists of 200 patients taken from the specialized dental center in Ba'aquba / Diyala g

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Zand, Nasrin, Leila Ataie-Fashtami, Parvin Mansouri, Mohsen Fateh, and Afshan Shirkavand. "Clinical Effect of Non-Thermal CO2 Laser Therapy (NTCLT) on Pain Relief of Oral Aphthous Ulcers of Behçet’s Disease." Journal of Lasers in Medical Sciences 12, no. 1 (2021): e72-e72. http://dx.doi.org/10.34172/jlms.2021.72.

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Introduction: Behçet’s disease (BD) is a debilitating and chronic vasculitis which can affect multiple organs. Recurrent oral aphthosis is the most common clinical feature of BD. The remarkable pain associated with painful oral ulcers can exert a major impact on the patients’ quality of life. Relieving pain of these oral ulcers is an essential approach in the management of mucocutaneous lesions of BD. Non-thermal CO2 laser therapy (NTCLT) as a novel photobiomodulative approach has recently been used for significant and immediate pain reduction of some types of painful oral lesions such as recu

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17

Sari, Rina Kartika, Diah Savitri Ernawati, and Bagus Soebadi. "RECURRENT APHTHOUS STOMATITIS RELATED TO PSYCHOLOGICAL STRESS, FOOD ALLERGY AND GERD." ODONTO : Dental Journal 6 (July 11, 2019): 45. http://dx.doi.org/10.30659/odj.6.0.45-51.

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Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress an

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CM Marya, Jiksha Mehlawat, Ruchi Nagpal, and Pratibha Taneja. "Low Level Laser Therapy (LLLT) in the Effective Management of Recurrent Aphthous Ulcers (RAU): Clinical Case Reporting 3 Patients: A Case Series." International Healthcare Research Journal 4, no. 12 (2021): CR4—CR8. http://dx.doi.org/10.26440/ihrj/0412.0399.

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Low-Level Laser therapy (LLLT) was employed for the treatment of three patients diagnosed with recurrent aphthous ulcers (RAU’s). The patients presented with recurrent aphthous ulcers in the region of floor of the mouth and buccal mucosa. The three patients with RAU’s were provided with a wavelength of946nm starting the use at 320µm fibre optic at a distance of 1-3 mm, peak power of 2W, frequency 10 Hz with no tissue contact in circular motion from outside to inside for 2 cycles with 100% duty for 30s for 3 consecutive days. The LLLT made possible an effective improvement in the reduction of p

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19

Jesudoss Prabhakaran, AC, and JP Angeline Archana. "Pharmacotherapy of recurrent aphthous ulcers." Chronicles of Young Scientists 2, no. 3 (2011): 134. http://dx.doi.org/10.4103/2229-5186.90889.

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20

Bittoun, Renée. "Recurrent aphthous ulcers and nicotine." Medical Journal of Australia 154, no. 7 (1991): 471–72. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121180.x.

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21

Konttinen, Y. T., R. H. Häyrinen-lmmonen, D. Nordström, et al. "Innervation of recurrent aphthous ulcers." Oral Microbiology and Immunology 9, no. 1 (1994): 60–64. http://dx.doi.org/10.1111/j.1399-302x.1994.tb00216.x.

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22

Borst, Johanna, and Lawrence Ma. "Oral ulcerations in a patient with autosomal dominant hyper-IgE syndrome (AD-HIES)." BMJ Case Reports 13, no. 11 (2020): e236705. http://dx.doi.org/10.1136/bcr-2020-236705.

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A 23-year-old woman with autosomal dominant hyper-IgE syndrome complicated by recurrent pneumonia and sinusitis presented with 1 week of multiple painful oral ulcers unresponsive to empiric antiviral and antifungal treatment. Her ulcers progressively worsened and she required hospitalisation for intravenous hydration and pain control. PCR swab of an ulcer was positive for varicella-zoster virus. Her symptoms never fully resolved despite antiviral therapy, and within 2 weeks, she relapsed with new and worsening ulcers. Biopsy revealed chronic active inflammation with no evidence of viral inclus

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Khozeimeh, Faezeh, Zahra Saberi, Atefeh Tavangar, and Fahime Fakhari Badi. "Effect of Herbal Echinacea on Recurrent Minor Oral Aphthous Ulcer." Open Dentistry Journal 12, no. 1 (2018): 567–71. http://dx.doi.org/10.2174/1874210601812010567.

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Background: The oral aphthous is a common oral ulcer with intense pain and there is no treatment for it, yet. Echinacea is an herbal medicine that moderated the immune system. Objective: The aim of this study was to investigate the effects of Echinacea on the treatment of aphthous ulcer. Methods: 50 patients with minor aphthous participated in our study. 25 patients take 3 tablets in a day for five weeks (case group) and 25 patients didn’t take any tablets (control group). The patients were monitored for one month before taking the tablets for six months. During this period, the number of lesi

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Prajapat, Jyoti, Rajesh Prajapat, Sanjeev B. Khanagar, et al. "Combination of Levamisole with Prednisone in Treating Recurrent Major Aphthous Ulcer in a Young Boy: A Case Report." Clinics and Practice 11, no. 2 (2021): 250–56. http://dx.doi.org/10.3390/clinpract11020038.

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Recurrent aphthous stomatitis (RAS) is an oral condition characterized by painful oral ulcerations. While the clinical features of this disease are easily defined, the etiology remains unclear. Thus, existing treatments are still unsatisfactory in reducing the severity, healing, and recurrence rate; however, there is no permanent and definitive treatment. Effective treatment for aphthous stomatitis is not available, and those treatments available mainly focus on suppressing its symptoms. We are reporting a case of a 17-year-old boy who presented with a 3-year history of multiple recurrent majo

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CM, Marya, Mehlawat Jiksha, Nagpal Ruchi, and Taneja Pratibha. "Low Level Laser Therapy (LLLT) in the Effective Management of Recurrent Aphthous Ulcers (RAU): Clinical Case Reporting 3 Patients: A Case Series." International Healthcare Research Journal 4, no. 12 (2021): CR4—CR8. https://doi.org/10.26440/IHRJ/0412.0399.

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Low-Level Laser therapy (LLLT) was employed for the  treatment of three patients diagnosed with recurrent aphthous ulcers (RAU’s). The patients presented with recurrent aphthous ulcers in the region of floor of the mouth and buccal mucosa. The three patients with RAU’s were provided with a wavelength of946nm starting the use at 320µm  fibre optic at a distance of 1-3 mm, peak power of 2W, frequency 10 Hz with no tissue contact in circular motion from outside to inside for 2 cycles with 100% duty for 30s for 3 consecutive days. The LLLT made possible an effective imp

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Warrier, Aravind, Maguluru Sruthi, and K. Anbarasi. "Comprehensive management of major aphthous ulcer." BMJ Case Reports 14, no. 5 (2021): e241010. http://dx.doi.org/10.1136/bcr-2020-241010.

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Recurrent aphthous ulcers are the most prevalent oral mucosal disease, but the subset major aphthous ulcer is a less frequent type. These ulcers are refractory, may persist for several weeks to months, and interfere with the normal state of health. The aetiology is multifactorial and so is the treatment. We present a case of an adolescent male patient reported with multiple oral ulcers. He developed three ulcers simultaneously and suffered for 10 months despite using topical medications prescribed by different dental practitioners. We executed a multidisciplinary treatment approach that result

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Taher, Aya K., and Nada JMH Radhi. "Salivary irisin in relation to recurrent aphthous ulcerand weight status in Diyala city/Iraq." Journal of Baghdad College of Dentistry 36, no. 1 (2024): 19–26. http://dx.doi.org/10.26477/jbcd.v36i1.3587.

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Background: Recurrent aphthous stomatitis remains the most common ulcerative disease of the oral mucosa that exists as painfull round shallow ulcers with a well-defined erythematous margin and a yellowish grey pseudomembranous centre. Salivary irisin is an identified adipomyokine and research has revealed that it has an anti-inflammatory effect and is a novel myokine; it is synthesized in skeletal muscle and adipose tissue. The aim of the present study was to evaluate the relation of salivary irisin to recurrent aphthous ulcers and weight status in Diyala City / Iraq. Materials and methods: A

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Slayter, Kathryn Lynn, and Thomas J. Marrie. "Treatment of Recurrent Aphthous Ulcers in an HIV Patient – An Emerging Use for Pentoxifylline." Canadian Journal of Infectious Diseases 9, no. 3 (1998): 189–90. http://dx.doi.org/10.1155/1998/569317.

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Patients with human immunodeficiency virus (HIV) infection often suffer from persistent, painful ulcers that commonly occur on the soft palate, buccal mucosa, tonsillar area or tongue, which are referred to as aphthous ulcers. This paper reports the case in which pentoxifylline was successfully used to treat recurrent aphthous ulcers in an HIV patient.

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Mahmood, Abdulsattar S., Sahar G. Al-Kazzaz, and Maha T. Al-Saffar. "Histological assessment of the effect of ginger on the healing of chemically-induced aphthous ulceration in rabbits." Review of Clinical Pharmacology and Pharmacokinetics - International Edition 38, no. 3 (2024): 283–89. http://dx.doi.org/10.61873/derc5205.

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Background: An aphthous ulcer is a painful and recurrent oral mucosal inflammation that is retractable to treatments and resistant to healing. Conventional treatments include a variety of antiseptic, anti-inflammatory, and analgesic therapies, yet their efficacy remains inconsistent. Aim: The present study was conducted in order to evaluate the effects of ginger powder on the healing of chemically-induced aphthous ulcers in rabbits. Methodology: Twelve healthy rabbits were divided into control and ginger-treatment groups. Aphthous ulcers were induced in both groups. The treatment group receive

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Amrutha, V. Das, Kumar Jain Anchal, Goel Aditya, Prajapati Indraprakash, and Khan Rimsha. "Efficacy of Rebamipide Therapy in Aphthous Ulcers: A Prospective Study." International Journal of Pharmaceutical and Clinical Research 16, no. 1 (2024): 817–20. https://doi.org/10.5281/zenodo.11100587.

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<strong>Background: </strong>Recurrent aphthous stomatitis (RAS) poses a considerable challenge within the Otorhinolaryngology domain, impacting patients’ quality of life. <strong>Aim and Objectives:</strong> This prospective study aimed to assess the efficacy of Rebamipide therapy in managing RAS over 3 months. <strong>Methods: </strong>A cohort of 60 patients with recurrent aphthous ulcers was enrolled, receiving Rebamipide therapy orally in a Tertiary care center of Central India. Clinical evaluations, pain scores, and ulcer healing rates were recorded at base

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Darakhshan, Sara, Mohammad Malmir, Fereshteh Bagheri, et al. "The effects of pomegranate peel extract on recurrent aphthous stomatitis." Current Issues in Pharmacy and Medical Sciences 32, no. 3 (2019): 115–20. http://dx.doi.org/10.2478/cipms-2019-0021.

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Abstract As high as 20% of the population is thought to have recurrent aphthous stomatitis (RAS), hence, finding new therapeutic agents may be needed. Pomegranate (Punica granatum), has been extensively used in the folk medicine of many cultures, as it possesses antioxidant, anti-inflammatory and anti-bacterial properties. In this study, it is hypothesized that a topical form of pomegranate peel extract (PPE) may shorten the duration, accelerate the healing and reduce the pain of RAS patients. The presented randomized, double-blind study was conducted on 56 patients. Herein, 28 patients were a

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Maurice, Monir, Wadie Mikhail, Medhat Aziz, and Maged Barsoum. "Aetiology of recurrent aphthous ulcers (RAU)." Journal of Laryngology & Otology 101, no. 9 (1987): 917–20. http://dx.doi.org/10.1017/s002221510010297x.

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AbstractA significant decrease in the pH of saliva has been detected in patients with recurrent aphthous ulcers (RAU). The decreae in pH was more prominent at night than between meals, and some persistent decrease was noticed even after recovery. The total proteins of saliva in RAU were also significantly decreased.These findings were similar to those observed in patients complaining of petic ulcers, so it is recommended that patients with RAU should be treated with antacids as well as anticholinergic drugs, and that the possibility of concomitant peptic ulceration should also be investigated.

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WALSH, NANCY. "Think Behçet's for Recurrent Aphthous Ulcers." Skin & Allergy News 40, no. 2 (2009): 32. http://dx.doi.org/10.1016/s0037-6337(09)70032-4.

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WALSH, NANCY. "Think Behçet's for Recurrent Aphthous Ulcers." Ob.Gyn. News 43, no. 24 (2008): 9. https://doi.org/10.1016/s0029-7437(08)70737-7.

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Hamdy, Ahmed Abd El-Meguid Mostafa, and Mohamed Abd El-Moneam Ibrahem. "Management of Aphthous Ulceration with Topical Quercetin: A Randomized Clinical Trial." Journal of Contemporary Dental Practice 11, no. 4 (2010): 9–16. http://dx.doi.org/10.5005/jcdp-11-4-9.

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Abstract Aim Recurrent aphthous ulceration is the most commonly known oral mucosal disease. Quercetin is a useful therapeutic agent for the treatment of colitis and gastric ulcer. The objective of this study was to determine the effect of topical application of quercetin in the treatment of minor aphthous ulcers. Methods and Materials Forty male patients with no known pathology of the oral mucosa other than minor aphthous ulcers were enrolled in this study. Patients were randomly divided into two groups, each consisting of 20 patients. Group 1 (control group) patients used a benzydamine hydroc

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Aleena, Sunny Ankitha George Anjali Jayakumar S.Hemalatha T.Sivakumar. "TOBACCO INDUCED APHTHOUS ULCERATION IN A 15 YEAR OLD BOY: A CASE REPORT." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 10 (2018): 9802–5. https://doi.org/10.5281/zenodo.1456649.

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Tobacco in all forms such as cigarettes, pipes, cigars, beedis, paan etc have been involved in development of ulcers that may lead to pre-malignancies or malignancies. Tobacco is a product prepared from the leaves of the tobacco plant of the genus Nicotiana and of the Solanaceae [nightshade] family. It is one of the most abused substances in the world. The addictive chemical present in tobacco is nicotine which is equally addictive as heroin, cocaine and alcohol. As per the epidemiological data provided by Centers for Diseases Control and Prevention tobacco causes 6 million deaths per year. To

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Manukonda, Deepthi Chandrika, Pavan Kumar Yellarthi, Suresh Kumar Pakki, N. V. V. Satya Bhushan, G. V. Radha, and Venkata Ramani Chintada. "Comparative Evaluation of Tacrolimus 0.1% in Orabase and Triamcinolone Acetonide 0.1% in the Management of Recurrent Apthous Stomatitis (RAS) – A Case Control Study." Journal of Pharmacy and Bioallied Sciences 16, Suppl 4 (2024): S4107—S4110. https://doi.org/10.4103/jpbs.jpbs_1498_24.

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ABSTRACT Background: Recurrent apthous stomatitis (RAS) and recurrent apthous ulcers are common oral ulcers which are associated with a significant amount of pain and reduction in quality of life, where traditional mainstay of treatment is topical steroids. Methodology: A case control study was undertaken on 90 patients seeking treatment for minor RAS and was divided into three groups. An index ulcer was selected and treated with 0.1% tacrolimus, 0.1% triamcinolone acetonide, and placebo, respectively, for 1 week. Results: At the end of day 2, the mean percentage reduction was 44.16%, 79.82% a

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Assiri, Hassan A., Ashwaq B. Majrashi, Reema K. Alqarni, and Mohammad S. Hameed. "Management of Concurrent Presentation of Aphthous Ulcer Major and Herpes Labialis." King Khalid University Journal of Health Sciences 10, no. 1 (2025): 88–91. https://doi.org/10.4103/kkujhs.kkujhs_31_24.

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Abstract Aphthous ulcers and herpes labialis (HL) are prevalent oral conditions, each with distinct origins and clinical appearances. Major aphthous ulcers, a variant of RAS, are less frequent and present as large recurrent, painful sores on the mucous membranes of the mouth, typically lacking a viral cause; their etiology appears to be multifactorial. In contrast, HL results from the reactivation of the herpes simplex virus, leading to clusters of vesicles primarily around the lip area. The co-occurrence of these conditions is unusual and can complicate both diagnosis and treatment due to the

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Mahdi, Karar Abdulzahra. "The Role of Sodium Lauryl Sulfate as a Causative Agent of Recurrent Aphthous Ulceration." Kufa Journal for Nursing Sciences 6, no. 1 (2016): 1–4. http://dx.doi.org/10.36321/kjns.vi20161.2634.

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Background: Sodium lauryl sulfate (SLS) is a detergent that has been used as the major surfactant in most dentifrices and could affect the barrier function of oral mucosa causing enhanced penetration of exogenous antigens. Objective: The aim of this clinical trial was to compare the effects of an SLS-free dentifrice and an SLS-containing dentifrice in patients suffering of recurrent aphthous ulcers . Method: This study was achieved in private clinic in 10/1/2015 to 1/6/2015,in this study, 33 volunteers (20 women, 13 men; mean age, 22 years: range, 15-35 years) were included, all have a history

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Faneesh, Kumar Priyanka Devi*. "Guava Leaf Extract as a Natural Therapeutic Agent in Aphthous Ulcer Management: A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2592–96. https://doi.org/10.5281/zenodo.15429600.

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Aphthous ulcers, or canker sores, are painful, recurrent lesions that significantly affect quality of life. Despite being self-limiting, the condition often demands therapeutic management due to pain, interference with daily functions, and recurrence. Conventional treatments such as topical corticosteroids, antiseptics, and immunomodulators come with side effects or cost limitations. Guava (Psidium guajava) leaves, traditionally used in herbal medicine, offer a natural and effective alternative with antimicrobial, anti-inflammatory, antioxidant, and wound-healing properties. This review evalua

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Gustuti, Violante. "A caval donato... guarda anche in bocca!" Medico e Bambino Pagine elettroniche 25, no. 5 (2022): 114. http://dx.doi.org/10.53126/mebxxvmg114.

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A 15-year-old girl with vulvar ulcers previously attributed to recurrent herpetic infection is presented. Aphthous oral ulcers were also present and the diagnosis of Behçet disease was eventually made.

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Kolenko, Y., A. Sinko, and N. Gryg. "Systemic immune inflammation index as a useful prognostic indicator in the prediction of chronic aphthous stomatitis." SUCHASNA STOMATOLOHIYA 121, no. 4 (2024): 12. http://dx.doi.org/10.33295/1992-576x-2024-4-12.

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Relevance. Chronic recurrent aphthous stomatitis (RAS) is one of the most common chronic inflammatory diseases of the oral cavity, which affects approximately 5 to 25% of the population. RAS is a multifactorial disorder, and studies have pointed to several potential causes associated with its occurrence. The aim is to analyse the role of inflammatory markers in the development of chronic recurrent aphthous stomatitis. Materials and methods. The study involved 80 patients: 29 men (36.25%) and 51 women (63.75%) with RAS who sought help at the Department of Therapeutic Dentistry of the Bogomolets

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Al-Samadi, A., A. Drozd, A. Salem, J. Hietanen, R. Häyrinen-Immonen, and Y. T. Konttinen. "Epithelial Cell Apoptosis in Recurrent Aphthous Ulcers." Journal of Dental Research 94, no. 7 (2015): 928–35. http://dx.doi.org/10.1177/0022034515581012.

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Ylikontiola, L., T. Sorsa, R. Häyrinen-Immonen, and T. Salo. "Doxymycine-cyanoacrylate treatment of recurrent aphthous ulcers." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 83, no. 3 (1997): 329–33. http://dx.doi.org/10.1016/s1079-2104(97)90238-9.

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Barrons, Robert W. "Treatment strategies for recurrent oral aphthous ulcers." American Journal of Health-System Pharmacy 58, no. 1 (2001): 41–50. http://dx.doi.org/10.1093/ajhp/58.1.41.

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Thantawi, Amelia, Khairiati ., Mela Meri Nova, Sri Marlisa, and Abu Bakar. "STOMATITIS APTHOSA REKUREN (SAR) MINOR MULTIPLE PRE MENSTRUASI (Laporan Kasus)." ODONTO : Dental Journal 1, no. 2 (2014): 57. http://dx.doi.org/10.30659/odj.1.2.57-62.

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Recurrent aphthous stomatitis (RAS) is an inflammation of the soft tissues of the mouth that is characterized by recurrent ulcers. SAR is clinically divided into three types, ie recurrent aphthous stomatitis minor, major and herpetiform. Clinical features of minor types usually with a diameter of about 2-4 mm with yellow-gray base and surrounded by an erythematous halo, affects mainly the non-keratinized mobile mucosae such as lips and tongue, a few ulcers (1-5) or multiple at a time, minor ulcers usually heal within 10-14 days without scarring. Early lesions on the SAR is usually felt by peop

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I. Hazeem, Muhamed, Muthenna Sh. Rajab, and Raed A. Badeia. "Treatment of Recurrent Aphthous Stomatitis with 940nm Diode Laser." Tikrit Journal for Dental Sciences 3, no. 1 (2024): 77–82. http://dx.doi.org/10.25130/tjds.2013.1.11.

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Background & objectives: Ulcers in the mouth (recurrent aphthous stomatitis) are very common and may vary in size from very small to very large. The exact cause of mouth ulcers isn’t known but acidic foods and stress are thought to be factors, as well as local traumatic damage such as that caused vigorous toothbrushing. Although uncomfortable, small ulcers are tolerable, but large ulcers can last for up to 2 weeks and greatly affect the ability to eat, drink and even talk. This study aimed to evaluate the efficacy of treatment of recurrent aphthous stomatitis by application of 940 nm diode

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Hasan, Shamimul, and Ahmad Umar. "Major recurrent aphthous ulcers treated with 5% amlexanox oral paste and rebamipide tablets- A case report with a brief literature review." IP International Journal of Periodontology and Implantology 9, no. 3 (2024): 161–65. http://dx.doi.org/10.18231/j.ijpi.2024.033.

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Recurrent aphthous stomatitis (RAS) is the most prevalent ulcerative condition of the oral mucosa, frequently affecting otherwise healthy individuals. It appears as painful ulcers on the soft tissues of the mouth, especially on the buccal mucosa, labial mucosa, and tongue. RAS is categorized into minor, major, and herpetiform ulcers, depending on ulcer size, distribution, and the healing process. A detailed medical history and systemic evaluation can assist the physician in determining whether the condition is idiopathic or related to an underlying systemic ailment. disorder. The unclear etiol

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Zwiri, Abdalwahab MA. "Anxiety, Depression and Quality of Life among Patients with Recurrent Aphthous Ulcers." Journal of Contemporary Dental Practice 16, no. 2 (2015): 112–17. http://dx.doi.org/10.5005/jp-journals-10024-1646.

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ABSTRACT Background Recurrent aphtous ulcers (RAUs) are of the most painful and common oral mucosal diseases with uncertain etiology including trauma, genetics, stress, immune dysfunction, and vitamin deficiencies. The aim of this study was to investigate the relationship between oral health impacts, patients’ oral health-related quality of life and anxiety and depression in patients with recurrent aphtous ulcers. Subjects and methods Sixty patients were diagnosed RAU (30 men and 30 women, mean age: 29.5 ± 9.6 years) and sixty controls, who matched the patients with age and gender, participate

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Sharma, Tanya, Nisha Dua, Prenika Sharma, Sukriti Mahajan, and Harpuneet Kaur. "Prevalence of aphthous stomatitis or recurrent aphthous ulcers in dental students." Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology 8, no. 1 (2022): 10–15. http://dx.doi.org/10.18231/j.jooo.2022.003.

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Aphthous stomatitis is a painful and recurrent inflammatory disorder affecting oral mucosa. It appears as oral manifestation of various diseases. It affects approximately 20% of the general population. Its etiopathogenesis is still unknown. Various risk factors and environmental factors are linked with its pathogenesis. Recently its association with stress has been emphasised in various studies. We tried to find out the most common site and cause of ulcerations in our subjects. A cross-sectional survey was conducted on 314 dental students by distributing a questionnaire via Google forms platfo

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