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Journal articles on the topic 'Recurrent Spontaneous Miscarriage (RSM)'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Radzinsky, V. E., and E. Y. Zapertova. "Progesterone-related changes in pro-inflammatory cytokines in recurrent miscarriage." Journal of obstetrics and women's diseases 53, no. 4 (2004): 59–61. http://dx.doi.org/10.17816/jowd88652.

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Habitual miscarriage (RMP) is a multifactorial, genetically determined disease. The NSP problem remains one of the most pressing problems in obstetrics and gynecology, as it entails not only a decrease in the birth rate, but also has a negative impact on the reproductive health of women. The frequency of spontaneous miscarriages ranges from 15 to 20% of desired pregnancies (Sidelnikova V.M., 2002). According to the Collegium of the Ministry of Health of the Russian Federation (2002), 50% of miscarriages occur in the first trimester, 25% of them occur in PNL. Moreover, every fifth desired pregn

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2

Al-Khateeb, Ghada, Mai Sater, and Wassim Almawi. "Contribution of functional IL-18 promoter polymorphisms to the risk of idiopathic recurrent spontaneous miscarriage (117.29)." Journal of Immunology 186, no. 1_Supplement (2011): 117.29. http://dx.doi.org/10.4049/jimmunol.186.supp.117.29.

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Abstract Interleukin (IL)-18 is a proinflammatory cytokine, which modulates Th1 differentiation and CTL effector activity, both of which were implicated in the pathogenesis of recurrent spontaneous miscarriage (RSM). We evaluate the association of single nucleotide polymorphisms (SNPs) in the IL18 gene promoter at -656G/T (rs1946519),-137G/C (rs187238), -119T/G (rs360718), and -105T/C (rs360717), were detected by TaqMan assays in analysis in 277 RSM cases and 283 control women matched for age and ethnic background; serum IL-18 level was measured by ELISA. Association of IL-18 alleles, genotype

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Al-Qahtani, Wadha Khalid, Afrah Fahad Alkhuriji, Zeneb Ahmed Babay, Aaishah Mohammed Hussain Kaabi, Nawal M. Al-Malahi, and Jamilah Obaid Alshammari. "Genetic Polymorphisms of Vascular Endothelial Growth Factor and Their Impact on Recurrent Spontaneous Miscarriage in Saudi Women." International Journal of Molecular Sciences 26, no. 10 (2025): 4757. https://doi.org/10.3390/ijms26104757.

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Recurrent spontaneous miscarriage (RSM) is defined as the loss of three or more clinically recognized pregnancies before 20 weeks of gestation. Angiogenesis, a crucial process in early pregnancy, is regulated by vascular endothelial growth factor (VEGF), a protein that plays a pivotal role in successful pregnancy. Disruptions in vascular development, such as those due to variations in VEGF gene expression, may contribute to infertility and pregnancy complications. Therefore, there is a need for more studies that show the effect of VEGF on RSM. This study investigated the impact of VEGF gene po

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Sater, Mai, та Wassim Almawi. "Autoantibodies targeting phosphatidylserine, cardiolipin, β2-glycoprotein I, annexin V and prothrombin in patients with recurrent spontaneous miscarriage (148.18)". Journal of Immunology 186, № 1_Supplement (2011): 148.18. http://dx.doi.org/10.4049/jimmunol.186.supp.148.18.

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Abstract An association between human reproductive failure and the presence of anti-phospholipid autoantibodies (APA) was suggested; both traditional and nontraditional APAs were associated with increased risk of recurrent spontaneous miscarriage (RSM). We measured levels of antibodies to phosphatidylserine (anti-PS), cardiolipin (ACA), β2-glycoprotein-I (anti-β2GPI), annexin V (anti-Anx V) and prothrombin (anti-PT) in 277 women with idiopathic RSM, and 288 control women by ELISA. Anti-PS IgG, ACA IgM/IgG, anti-Anx V IgM/IgG, and anti-PT IgM positivity were significantly associated with higher

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5

Yao, Yongli, Fan Hao, Lin-Chen Tang, Xiang-Hong Xu, and Liping Jin. "Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage." Molecular Human Reproduction 26, no. 7 (2020): 521–31. http://dx.doi.org/10.1093/molehr/gaaa035.

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Abstract Recurrent spontaneous miscarriage (RSM) is a systemic disorder that has been defined as two or more pregnancies lost before the 20th week of gestation. Although the impaired function of macrophages at the maternal–fetal interface has been reported to be associated with RSM, the underlying mechanisms have not been fully elucidated. Here, we revealed that HDAC8 plays a critical role in RSM. Our results show that the mRNA and protein expression of HDAC8 was decreased in decidual macrophages from RSM patients. Moreover, the knockdown of HDAC8 resulted in a significant decrease in CD163 ex

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Salimi, Saeedeh, Saman Sargazi, Behrouz Mollashahi, et al. "Association of Polymorphisms in miR146a, an Inflammation-Associated MicroRNA, with the Risk of Idiopathic Recurrent Spontaneous Miscarriage: A Case-Control Study." Disease Markers 2022 (April 30, 2022): 1–10. http://dx.doi.org/10.1155/2022/1495082.

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It has been established that microRNAs (miRNAs) are involved in the regulation of immune responses and serve as biomarkers of inflammatory diseases as well as recurrent spontaneous miscarriage (RSM). Herein, we aimed to study the relationship between three functional miR146a gene polymorphisms with idiopathic RSM (IRSM) susceptibility. We recruited 161 patients with IRSM and 177 healthy women with at least one live birth and without a history of abortion. Genotyping was performed using RFLP-PCR and ARMS-PCR methods. We found that the rs6864584 T/C decreased the risk of IRSM under dominant TT+T

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7

Sonam, Bindal, and Satyanarayana Nanduri Venkata. "Role of Yoga Prana Vidya (YPV) System Protocols in Infertility Treatment: A Case Study of A 29-Year-Old House Wife with History of Recurrent Spontaneous Miscarriages and Ovarian Cysts." INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND BIO-MEDICAL SCIENCE 02, no. 10 (2022): 414–18. https://doi.org/10.5281/zenodo.7208768.

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<strong>INTRODUCTION: </strong>Recurrent spontaneous miscarriage (RSM) affects 1 to 2 % of women causing anxiety and worry for self and family. Ovarian cysts are perhaps the most common issue among women trying to conceive. This paper presents a case of a 29-year-old married woman having ovarian cyst and suffered two miscarriages, was treated successfully using YPV healing protocols. METHOD: This paper used case study method going through patient medical records, healer’s records and patient feedback.   <strong>RESULTS: </strong>The patient experienced successful pregnancy

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8

Abed, Shurooq Hussamaldeen, та Yossra Saleh Khudhur. "Decreased β-catenin Expression in First Trimester Villi and Decidua of Patients with Recurrent Spontaneous Miscarriage". Medical Journal of Tikrit University 29, № 2 (2023): 53–60. http://dx.doi.org/10.25130/mjotu.29.1.8.

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Accumulating evidence suggests that Wnt/β-catenin pathways play an important role in the physiological processes of endometrial development and differentiation, preimplantation embryo development, and blastocyst implantation. The objective of the current study was to signify the association between Wnt/β-catenin signalling pathway and recurrent spontaneous miscarriage and examine the expression of β-catenin first-trimester villi and decidua in women with spontaneous miscarriage. A comparative cross-sectional study was conducted in Saladin General Hospital from the 1st of January to the 1st of

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9

Asaad Abdallah. "Etiology of recurrent spontaneous abortion." World Journal of Advanced Research and Reviews 19, no. 3 (2023): 029–33. http://dx.doi.org/10.30574/wjarr.2023.19.3.1724.

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Spontaneous abortion and miscarriage are synonymous terms. In medical literature, spontaneous abortion is most often used, while in clinical practice and among the general population miscarriage is the preferred term. Spontaneous abortion or miscarriage is defined as the involuntary end of pregnancy before 20 weeks of gestation. Recurrent pregnancy loss (RPL), also known as recurrent miscarriages, is defined by the consecutive loss of two or more pregnancies with the same partner and having no more than one living child. The aim of this review is to highlight the most common Etiology of Recurr

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10

Asaad, Abdallah. "Etiology of recurrent spontaneous abortion." World Journal of Advanced Research and Reviews 19, no. 3 (2023): 029–33. https://doi.org/10.5281/zenodo.11529827.

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Spontaneous abortion and miscarriage are synonymous terms. In medical literature, spontaneous abortion is most often used, while in clinical practice and among the general population miscarriage is the preferred term. Spontaneous abortion or miscarriage is defined as the involuntary end of pregnancy before 20 weeks of gestation. Recurrent pregnancy loss (RPL), also known as recurrent miscarriages, is defined by the consecutive loss of two or more pregnancies with the same partner and having no more than one living child. The aim of this review is to highlight the most common Etiology of Recurr

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11

Stefanidou, E. M., L. Caramellino, G. Gallone, A. Patriarca, and G. Menato. "O655 SELENIUM IN RECURRENT SPONTANEOUS MISCARRIAGE." International Journal of Gynecology & Obstetrics 119 (October 2012): S491. http://dx.doi.org/10.1016/s0020-7292(12)61085-6.

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12

Gratz, Michael J., Stavroula Stavrou, Christina Kuhn, et al. "Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages." Endocrine Connections 7, no. 5 (2018): 727–38. http://dx.doi.org/10.1530/ec-18-0126.

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Objectives l-dopa decarboxylase (DDC) is responsible for the synthesis of dopamine. Dopamine, which binds to the D2-dopamine receptor (D2R), plays an important role in the maintenance of pregnancy. Aim of our study was the analysis of DDC and D2R expression in placentas of spontaneous miscarriages (SMs) and recurrent miscarriages (RMs) in comparison to healthy controls. Methods Patients with SM (n = 15) and RM (n = 15) were compared with patients from healthy pregnancies (n = 15) (pregnancy weeks 7–13 each). Placental tissue has been collected from SMs and RMs from the first trimester (Departm

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13

Zhang, Lingyan, and Kai'e Zhe. "The Role of Immunological Factors in Recurrent Miscarriage and Advances in Immunotherapy." Advanced Journal of Nursing 5, no. 2 (2024): 35. http://dx.doi.org/10.32629/ajn.v5i2.2449.

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Recurrent miscarriage is a complex reproductive health problem when a woman suffers spontaneous miscarriage during two or more consecutive pregnancies. Recurrent miscarriage is a distressing condition in which immune factors play an important role. The immune system has an impact on the processes of embryo implantation, growth and development, and immune abnormalities may lead to rejection of the foetus or difficulties in implantation, thus triggering recurrent miscarriage. Therefore, the role of immune factors in recurrent miscarriages and advances in immunotherapy will open up more possibili

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14

Krishnaswamy, Priyanka, and Rohit Arora. "Recurrent pregnancy loss." InnovAiT: Education and inspiration for general practice 13, no. 7 (2019): 402–8. http://dx.doi.org/10.1177/1755738019883326.

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Miscarriage is defined as the spontaneous loss of a pregnancy before the fetus reaches viability; it includes all pregnancy losses from the time of conception until 24 weeks of gestation. Early miscarriages are common, occurring in 10–20% of all pregnancies, with 2% of second-trimester pregnancies being miscarried before 24 weeks of gestation. Recurrent miscarriage, defined as the loss of three or more consecutive pregnancies, affects 1% of couples trying to conceive with the chance of having two consecutive miscarriages being 5%. Clinical studies show that 3 in 4 women will have a successful

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15

Zubair, Hina, Amber-u.-Nissa Soomro, Shafqat Mukhtar, and Aurooj Fatima. "Spontaneous Miscarriage in Women Having More Than Three Miscarriages and Advanced Maternal Age." Pakistan Journal of Medical and Health Sciences 15, no. 8 (2021): 2172–74. http://dx.doi.org/10.53350/pjmhs211582172.

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Background: Miscarriages are negative outcomes of a pregnancy. Their ratio increases in women with recurrent miscarriages. Objective: To identify the role of age and recurrent miscarriages in spontaneous abortions. Study Design: Comparative analytical study Place and Duration of Study: Department of Obstetrics & Gynecology, Mohtarma Benazir Bhutto Medical College Mir Pur, Azad Kashmir from 1st October 2020 to 31st March 2021. Methodology: One hundred and twenty pregnant women between the age group of 19-40 years. The clinical history of recurrent miscarriages and demography was noted. Resu

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16

Malyshkina, A. I., N. Yu Sotnikova, A. V. Kust, and D. N. Voronin. "REGULATION OF PERIPHERAL B-LYMPHOCYTE DIFFERENTIATION IN RECURRENT MISCARRIAGE." Medical Immunology (Russia) 23, no. 4 (2021): 711–16. http://dx.doi.org/10.15789/1563-0625-rop-2295.

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The important role of immune disorders in recurrent miscarriage has been proven. Clarification of the character of B-lymphocyte differentiation and its regulation factors in women with threatened miscarriage and recurrent miscarriage in history is an urgent problem, since it will reveal the immune mechanisms of the pathogenesis of this pathology. Purpose: to establish the features of B-lymphocyte differentiation and factors of its regulation in women with a history of recurrent miscarriage and threatening spontaneous miscarriage at the time of examination.Were examined pregnant women aged 18-4

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17

Jaiswal, Sneha, and Tarasankar Bag. "Anti-thyroid peroxidase antibody positivity and other obstetric complications in women with recurrent miscarriage." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 1 (2016): 190. http://dx.doi.org/10.18203/2320-1770.ijrcog20164655.

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Background: Thyroid dysfunction and autoimmunity are relatively common in women of reproductive age group and has been associated with various adverse pregnancy outcomes such as recurrent miscarriage, preeclampsia and preterm labour. The aim of this study was to find out association between anti-tpo antibody and recurrent miscarriage and to evaluate obstetric complications such as preeclampsia and preterm labour in them.Methods: This case control observational study was carried out from July 2014 to June2015 on 110 pregnant mothers out which 55 with history of recurrent miscarriage were cases

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18

Visternicean, Elena. "Homocysteine and recurrent miscarriage." Moldovan Medical Journal 60, no. 1 (2017): 15–19. https://doi.org/10.5281/zenodo.1050325.

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<strong>Background: </strong>It is known that etiological structure of recurrent miscarriage has genetic, anatomical, infectious and immunological factors; however, the cause of recurrent miscarriage in 50-60% of cases is not completely clear. Homocysteine is a sulfur-containing intermediate product in the normal metabolism of methionine. Development mechanisms of vascular complications of hyperhomocysteinemia are currently being intensively studied. Hyperhomocysteinemia affects a number of mechanisms involved in thrombogenesis including coagulation cascade, vessel-thrombocytic

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19

Vomstein, Kilian, Anna Aulitzky, Laura Strobel, et al. "Recurrent Spontaneous Miscarriage: a Comparison of International Guidelines." Geburtshilfe und Frauenheilkunde 81, no. 07 (2021): 769–79. http://dx.doi.org/10.1055/a-1380-3657.

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AbstractWhile roughly 30% of all women experience a spontaneous miscarriage in their lifetime, the incidence of recurrent (habitual) spontaneous miscarriage is 1 – 3% depending on the employed definition. The established risk factors include endocrine, anatomical, infection-related, genetic, haemostasis-related and immunological factors. Diagnosis is made more difficult by the sometimes diverging recommendations of the respective international specialist societies. The present study is therefore intended to provide a comparison of existing international guidelines and recommendations. The guid

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Mochalova, Marina N., Anna I. Galeeva, Ilya B. Plotkin, Elena M. Chatskis, and Lyubov A. Kuzmina. "Successful pregnancy outcome after pre-pregnancy transabdominal cerclage in a patient with cervical insufficiency." Journal of obstetrics and women's diseases 74, no. 1 (2025): 152–57. https://doi.org/10.17816/jowd634153.

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Presently, recurrent miscarriage remains an urgent medical and social problem. This pathology affects the female reproductive function and consequently leads to a decrease in the birth rate. The etiology of recurrent miscarriage is frequently attributed to cervical insufficiency. This condition is associated with spontaneous abortion and early preterm birth, which significantly increases perinatal mortality and morbidity of newborns in the early neonatal period. This paper presents a case of full-term pregnancy after laparoscopic transabdominal cerclage at the pre-pregnancy stage. The patient

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Ruqaya K. Abbas, Amani M. Jasim, and Qater Al-nada A. Al-Ibady. "Assessment of Some Biochemical Parameters in Iraqi Women with Recurrent Miscarriage." Journal of Techniques 4, no. 33 (2022): 175–80. http://dx.doi.org/10.51173/jt.v4i33.850.

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Miscarriage a is pregnancy loss that occurs within the first 23 weeks. The risk factors that increase miscarriage is multivariate. Spontaneous loss of a conception before the 20th week of pregnancy is known as a miscarriage. There are two types of miscarriage: spontaneous and recurrent, one or more sporadic miscarriages affects approximately 25 – 50 percent of all women. Recurrent miscarriage, on the other hand, affects about 1% of couples trying to conceive. There are a number of things that can cause a miscarriage, such as inflammatory and immune system diseases. This study aims to compare t

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Sanmi, Emiade, Musa Bolanle OP, Oguntayo Adekunle O, Hassan Abduazeez A, and Balogun Yemi. "An Appraisal of Recurrent Miscarriage in Sub-Saharan Africa: Occurrence and Possible Solution." Clinical Journal of Obstetrics and Gynecology 7, no. 4 (2024): 103–6. http://dx.doi.org/10.29328/journal.cjog.1001173.

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A recurrent miscarriage may be defined in the African context as the foetal demise of two or more successive pregnancies before the attainment of the age of viability. A literature review was done to assess the trend of recurrent miscarriage in sub-Saharan Africa. Identifying the main causes, considering the population at risk, and the availability of accurate diagnostic utilities to effectively ensure good management of recurrent miscarriage is an important gynaecologic issue. Over the years, studies have identified several etiologies and yet there’s been no tangible implementation of therape

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Kust, A. V., N. Y. Sotnikova, A. I. Malyshkina, and D. N. Voronin. "Role of CD20 + IL-10 + B-lymphocytes in immunoregulatory processes in women with reccurent miscarriage." Russian Clinical Laboratory Diagnostics 66, no. 8 (2021): 485–88. http://dx.doi.org/10.51620/0869-2084-2021-66-8-485-488.

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To determine the level of CD20 + IL-10 + B-lymphocytes in pregnant women with the threat of termination of pregnancy at 5-12 weeks and recurrent miscarriage in history and compare the data obtained with the end of gestation. A survey of 65 women at a gestational age of 5-12 weeks was carried out. The main group consisted of 33 women with a threatening recurrent miscarriage at the time of the examination, the comparison group consisted of 10 pre-pregnant women with a threatening sporadic miscarriage at the time of the examination, the control group consisted of 22 pregnant women without signs o

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Knabl, Julia, Aurelia Pestka, Rebecca Hüttenbrenner, et al. "The Liver X Receptor in Correlation with Other Nuclear Receptors in Spontaneous and Recurrent Abortions." PPAR Research 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/575604.

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The liver X receptors (LXRs) have been shown to be crucially involved in maternal-fetal cholesterol transport and placentation. The aim of this study was to investigate the expression pattern and frequency of LXR under normal physiological circumstances and in spontaneous abortion and/or recurrent miscarriage. A total of 29 (12 physiologic pregnancies/10 spontaneous abortions/7 recurrent miscarriages) human pregnancies in first trimester were analysed for LXR expression. Expression changes were evaluated by immunohistochemistry for receptor and quantitative RT-PCR (TaqMan) was performed to det

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Roberts, Judith, Carol Jenkins, Rhoda Wilson, et al. "Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies." European Journal of Endocrinology 134, no. 1 (1996): 84–86. http://dx.doi.org/10.1530/eje.0.1340084.

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Roberts J. Jenkins C, Wilson R, Pearson C, Franklin IA, MacLean MA, McKillop JH, Walker JJ. Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies. Eur J Endocrinol 1996;134:84–6. ISSN 0804–4643 The aim of this study was to determine whether recurrent miscarriage (three or more miscarriages, no live children) was associated with an increased incidence of autoantibodies. Five groups were enrolled into the study; healthy non-pregnant women, healthy first-trimester pregnant women, women suffering spontaneous abort

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Grigushkina, E. V., N. Yu Sotnikova, N. V. Kroshkina, A. I. Malyshkina, and I. E. Talanova. "FEATURES OF MONOCYTE POLARIZATION AT DIFFERENT OUTCOMES IN WOMEN WITH RECURRENT MISCARRIAGE." Medical Immunology (Russia) 23, no. 4 (2021): 755–60. http://dx.doi.org/10.15789/1563-0625-fom-2291.

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Currently, in the pathogenesis of recurrent miscarriage, a special role is given to immunological factors, in particular the role of innate immunity. The aim of the study was to assess the relative content of monocytes in the peripheral blood producing IL-4, IL-6, IL-10, IFNγ, as well as to identify new criteria for predicting the outcome of pregnancy in women with the threat of early termination and recurrent miscarriage. Materials and methods. 88 pregnant women at 5-12 weeks’ gestation were examined, the main group consisted of 59 women with recurrent miscarriage and threatened miscarriage a

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Al-Hakeem, Aaya Hamid, Marwa Ahmed Meri, and Hadeel Haider Aldujaili. "Placenta Accreta Spectrum." Medical Science Journal for Advance Research 3, no. 1 (2022): 1–11. http://dx.doi.org/10.46966/msjar.v3i1.33.

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Histopathological examination of products of conception from miscarriages is part of routine clinical practice. The extent of additional clinically relevant information provided by this investigation in the setting of recurrent spontaneous abortion remains uncertain. The included studies indicated that such examination identify hydatid form moles, villous dysmorphic features suggesting fetal aneuploidy, chronic histiocytic intervillositis (CHI) and massive per villous fibrin deposition and impaired trophoblast invasion. However, in most cases, morphological assessment cannot reliably determine

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Diejomaoh, Michael, Jiri Jirous, Magda Al-Azemi, Saba Baig, Madhu Gupta, and Alaa Tallat. "The Relationship of Recurrent Spontaneous Miscarriage with Reproductive Failure." Medical Principles and Practice 12, no. 2 (2003): 107–11. http://dx.doi.org/10.1159/000069122.

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Bulletti, C. "Reproductive failure due to spontaneous abortion and recurrent miscarriage." Human Reproduction Update 2, no. 2 (1996): 118–36. http://dx.doi.org/10.1093/humupd/2.2.118.

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Mahdi, N. K. "W180 ANTICARDIOLIPIN ANTIBODY IN WOMEN WITH RECURRENT SPONTANEOUS MISCARRIAGE." International Journal of Gynecology & Obstetrics 119 (October 2012): S763. http://dx.doi.org/10.1016/s0020-7292(12)61905-5.

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Al-Akaidi, Marwa Adel Hussein, Mais Adnan Al_ward, ASMAA A. JAWAD, et al. "Recurrent miscarriage and factors that effects its: A review." Al-Salam Journal for Medical Science 3, no. 2 (2024): 40–46. http://dx.doi.org/10.55145/ajbms.2024.03.02.06.

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Spontaneous abortion is a commonly occurring issue during human pregnancy. The definition provided by the WHO in 1977 is universally accepted. Recurrent pregnancy loss is a multifaceted health issue that lacks a universally agreed-upon definition. The lack of agreement in definitions encompasses not only the varying number of spontaneous abortions (two or three) that are considered recurrent pregnancy losses but also the different types of pregnancies and the gestational age at which the miscarriage occurs. The prevalence among clinical pregnancies is approximately less 15%, but when early pre

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A., Coomarasamy, and J. Devall A. "SPORADIC PREGNANCY LOSS AND RECURRENT MISCARRIAGE." REPRODUCTIVE ENDOCRINOLOGY, no. 56 (December 30, 2020): 88–94. https://doi.org/10.18370/2309-4117.2020.56.88-94.

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Progesterone is essential for the maintenance of pregnancy, and progesterone deficiency is associated with miscarriage. The subject of whether progesterone supplementation in early pregnancy can prevent miscarriage has been a long-standing research question and has been investigated and debated in the medical literature for over 70 years. During this time, several different progestogens have been synthesised and tested for the prevention of miscarriage. In this article described the prior evidence alongside the latest research using micronized natural progesterone as well as synthetic progesto

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Taşkıran, Deniz, and Salih Kolsuz. "A Review of the Effect of Progesterone Use on Miscarriage in Early Pregnancy Bleeding." CERASUS JOURNAL OF MEDICINE 2, no. 2 (2025): 80–84. https://doi.org/10.70058/cjm.1580454.

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Pregnancy-related psychological and physiological issues can arise from treating impending miscarriage, miscarriage, and repeated pregnancy loss. Treatment is challenging since miscarriage and recurrent pregnancy loss have no obvious etiopathogenesis and are caused by a variety of causes. The pregesterone derivatives utilized in treatment, their administration method, length, and which derivative works best for treating the condition are all unclear. Threatened abortion, spontaneous abortion, incomplete abortion, and full abortion are the different categories of miscarriages.The basis for this

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EMARAH, MOHAMED S. A., MOHAMED A. EL-NAGGAR, ABEER EL SHABACY, and SAHAR H. QUSHWA. "Hypothyroidism In Women With Recurrent Spontaneous Abortion." Advances in Social Sciences Research Journal 7, no. 10 (2020): 71–77. http://dx.doi.org/10.14738/assrj.710.9132.

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   Recurrent miscarriage, defined as loss of two or more consecutive pregnancies, occurs in 1–2% of couples attempting to bear children. The major causes of recurrent pregnancy loss (RPL) based on the literature include parental structural chromosome rearrangement, immunologic factors (i.e. antiphospholipid syndrome), thrombophilic factors (both inherited and acquired), anatomic factors of uterine anomalies, and endocrinologic disorders. Luteal phase defect, polycystic ovarian syndrome (PCOS), diabetes mellitus, thyroid disease and hyperprolactinemia are among the endocrinolo

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Stagnaro-Green, Alex. "Thyroid Antibodies and Miscarriage: Where Are We at a Generation Later?" Journal of Thyroid Research 2011 (2011): 1–7. http://dx.doi.org/10.4061/2011/841949.

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In 1990, an association between thyroid antibody positivity and spontaneous miscarriage was first reported. A generation has passed since the initial observation. Over that time a robust literature has developed which has confirmed the initial finding and expanded upon it. The present paper reviews the literature that has been generated over the last twenty years on the following topics: (1) thyroid antibodies and spontaneous miscarriage, (2) thyroid antibodies and recurrent abortion, (3) etiology of pregnancy loss in thyroid antibody positive women, and (4) discussion of future research direc

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Hirsch, Martin, Dan Reisel, Ertan Saridogan, and Anna L. David. "Endoscopic transabdominal cervical cerclage replacement after recurrent late miscarriage." BMJ Case Reports 15, no. 2 (2022): e247757. http://dx.doi.org/10.1136/bcr-2021-247757.

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Transabdominal cerclage (TAC) is a recognised treatment for recurrent spontaneous late miscarriage or preterm birth due to cervical weakness. This can be performed via an open procedure before and during pregnancy, or a laparoscopic technique preconception. Complications include cerclage failure and suture migration. We present a case highlighting these complications where laparoscopic removal of an open TAC and replacement led to two successful term deliveries. A woman in her thirties with a fibroid uterus, adenomyosis and a history of three spontaneous mid-trimester losses, had an open TAC a

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Sotnikova, N. Yu, A. I. Malyshkina, A. V. Kust, and D. N. Voronin. "Analysis of the differentiation of peripheral B-lymphocytes in pregnant women with a habitual miscarriage." Сибирский научный медицинский журнал 41, no. 3 (2021): 38–44. http://dx.doi.org/10.18699/ssmj20210305.

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The frequency of recurrent miscarriage among all desired pregnancies is 2-5 %. The important role of immune disorders in early termination of pregnancy has been proven. Elucidation of the nature of differentiation of B-lymphocytes in women with threatened miscarriage and habitual miscarriage in the anamnesis seems relevant, since it will clarify the immune mechanisms of the pathogenesis of this pathology. Aim of the study was to assess the nature of differentiation and type of the cytokine-producing function of peripheral B lymphocytes in women with a threatening spontaneous miscarriage and re

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Stefanski, Ana-Luisa, Christoph Specker, Rebecca Fischer-Betz, Wolfgang Henrich, Ekkehard Schleussner, and Thomas Dörner. "Maternal Thrombophilia and Recurrent Miscarriage – Is There Evidence That Heparin is Indicated as Prophylaxis against Recurrence?" Geburtshilfe und Frauenheilkunde 78, no. 03 (2018): 274–82. http://dx.doi.org/10.1055/s-0044-100919.

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Abstract Background Recurrent miscarriage, also referred to as recurrent spontaneous abortion (RSA), affects 1 – 5% of couples and has a multifactorial genesis. Acquired and congenital thrombophilia have been discussed as hemostatic risk factors in the pathogenesis of RSA. Method This review article was based on a selective search of the literature in PubMed. There was a special focus on the current body of evidence studying the association between RSA and antiphospholipid syndrome and hereditary thrombophilia disorders. Results Antiphospholipid syndrome (APS) is an acquired autoimmune thrombo

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Karhukorpi, Jari, Tarja Laitinen, and Anja S. Tiilikainen. "HLA-G polymorphism in Finnish couples with recurrent spontaneous miscarriage." BJOG: An International Journal of Obstetrics and Gynaecology 104, no. 10 (1997): 1212–14. http://dx.doi.org/10.1111/j.1471-0528.1997.tb10951.x.

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Smith, Samuel. "Use of the Laboratory in Infertility and Recurrent Spontaneous Miscarriage." Clinics in Laboratory Medicine 12, no. 3 (1992): 393–410. http://dx.doi.org/10.1016/s0272-2712(18)30496-7.

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Wei, Xian Jiang, Xiao Qin Fang, and Ling Tong. "Lymphocyte active immunotherapy for unexplained recurrent spontaneous abortion." Bangladesh Journal of Pharmacology 13, no. 4 (2018): 316–29. http://dx.doi.org/10.3329/bjp.v13i4.37278.

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This study is to evaluate the curative effect of lymphocyte active immune treatment for unexplained recurrent spontaneous abortion. Fourteen randomized controlled trials of 994 subjects were included. Blocking antibody positive rate of patients who experienced a new pregnancy showed significant differences between immunotherapy and placebo. Moreover, live birth rate among paternal or third-party donor lymphocytes and placebo groups had significant difference [RR= 1.63, 95% CI (1.38-1.92), p＜0.05]. Trial sequential analysis showed that the Z-curve crosses the trial sequential monitoring boundar

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Bourzoufi, Mariam, Bouziane Nedjar, Tahiri Hafssa, Saadi Hanan, and Ahmed Mimouni. "OBSTETRICAL PROGNOSIS AFTER UTERINE SEPTUM SECTION BY HYSTEROSCOPYABOUT A CASE REPORT." International Journal of Advanced Research 10, no. 03 (2022): 558–62. http://dx.doi.org/10.21474/ijar01/14418.

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The septate uterus is the most common congenital uterine malformation resulting from a resorption defect of the inter-mullerian septum. It is frequently associated with conception abnormalities such as early recurrent spontaneous miscarriage (FCS) and late recurrent miscarriage (FCT) but also with fertility abnormalities, without a clear mechanism. The imaging techniques used to diagnose a septate uterus are based on : Endo-vaginal ultrasound, diagnostic hysteroscopy and IRM pelvic . Surgical treatment is based on septum sectioning which is a minimally invasive surgical technique with low risk

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Turesheva, Akbayan, Gulzhanat Aimagambetova, Talshyn Ukybassova, et al. "Recurrent Pregnancy Loss Etiology, Risk Factors, Diagnosis, and Management. Fresh Look into a Full Box." Journal of Clinical Medicine 12, no. 12 (2023): 4074. http://dx.doi.org/10.3390/jcm12124074.

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Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. Inconsistency in definitions involves not only the number of spontaneous abortions (two or three) that are accepted for recurrent pregnancy loss but the types of pregnancy and gestational age at miscarriage. Due to the heterogeneity of definitions and criteria applied by international guidelines for recurrent pregnancy loss, the true incidence of recurrent miscarriage, which is reported to range from 1% to 5%, is difficult to estimate. Moreover, the exact etiology of recurrent pregnancy loss remains

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Jassim, T. S., A. M. M. Al-Fendi, S. T. Hashim, T. H. Saleh, and B. A. L. Al-Rubaii. "Molecular detection of Rubella virus (1E genotype) in clinical sample of pregnant women, and it’s related to abortion." Reproductive health of woman, no. 3 (May 23, 2025): 113–18. https://doi.org/10.30841/2708-8731.3.2025.331563.

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Pregnant women who have rubella may potentially pass the infection on to their unborn offspring. A congenital rubella infection can result in a miscarriage, stillbirth, and congenital rubella syndrome. The only member of the Togaviridae family’s Rubivirus genus, the Rubella virus (RV) is a positive-polarity, single-stranded RNA virus genome surrounded by a lipoprotein envelope with spike-like, hemagglutinin-containing surface projections.The objective: to determine the Rubella virus (1E genotype) in pregnant woman and its relation to spontaneous miscarriage.Materials and methods. A total of 17

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Mahaputra, I. Komang Bintang Satria, I. Made Udiyana Indradiputra, and I. Dewa Gede Reza Sanjaya. "Varicocelectomy For Infertile Men with Clinical Varicocele and Normal Semen Parameters, In Relation to Pregnancy Rate and Recurrent Spontaneous Miscarriage Incidence: A Systematic Review." Brawijaya Journal of Urology 4, no. 01 (2023): 10–14. http://dx.doi.org/10.11594/bjurology.2023.004.01.3.

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Objectives. Current guidelines suggest performing varicocelectomy only for men with clinical varicocele, infertile, abnormal semen parameters, and impaired testicular development. Varicocelectomy in infertile men with normal semen parameters was deemed to not benefit fertility significantly. The purpose of this systematic review is to discuss articles that studied varicocelectomy in men with clinical varicocele, normal semen analysis, and normal women who experience infertility or spontaneous miscarriage and find out whether there is an improvement in pregnancy and live birth rate.Methods. The

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Толмачева, Е. Н., Е. А. Саженова, Т. В. Никитина, et al. "Epigenetic modifications of the X chromosome in families with miscarriage." Nauchno-prakticheskii zhurnal «Medicinskaia genetika», no. 11(220) (November 30, 2020): 81–82. http://dx.doi.org/10.25557/2073-7998.2020.11.81-82.

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Асимметричная инактивация Х-хромосомы характерна как для женщин с привычным невынашиванием, так и для спонтанных абортусов с кариотипом 46,XX, а смещение инактивации у спонтанного абортуса чаще связано с наличием асимметричной инактивации у матери. Skewed inactivation of the X chromosome is characteristic for women with recurrent pregnancy loss and spontaneous abortions with a karyotype 46,XX. Skewed X-inactivation in spontaneous abortion is more often associated with the asymmetric inactivation in the mother.

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Sekal, Mohammed, Ahmed Lazraq, Kenza Bennani, Abdelilah Melhouf, and Taoufiq Harmouch. "The Main Causes of Recurrent Spontaneous Miscarriages." SAS Journal of Surgery 9, no. 05 (2023): 447–49. http://dx.doi.org/10.36347/sasjs.2023.v09i05.022.

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Summary: Repeated spontaneous miscarriages are defined as at least three consecutive episodes of spontaneous miscarriage, less than 14 weeks of amenorrhea, with the same partner, in a patient under 40 years of age. 80% of these patients have an identifiable cause justifying an etiological approach. A guided history and clinical examination are necessary. An etiological assessment is to be carried out: a pelvic ultrasound and a hormonal assessment in the woman, as well as a karyotype of the two members of the couple. The other examinations are requested as a second intention. The main causes ar

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Malyshkina, Anna I., Natalia Y. Sotnikova, Dmitriy N. Voronin, and Alena V. Kust. "Regulation of the functional activity of peripheral B lymphocytes in pregnant women with a history of recurrent miscarriage." Journal of obstetrics and women's diseases 70, no. 4 (2021): 73–79. http://dx.doi.org/10.17816/jowd62675.

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BACKGROUND:The frequency of recurrent miscarriage is up to 5 % of all desired pregnancies and is mainly due to immunological disorders. Dysfunction in the regulation of the functional activity of B lymphocytes is the pathogenetic link in multiple obstetric complications, including habitual miscarriage. AIM:The aim of this study was to characterize the regulation of the functional activity of peripheral B lymphocytes in pregnant women with threatened spontaneous miscarriage and a history of habitual miscarriage. MATERIALS AND METHODS:We examined 88 women aged 18-40 years at a gestat

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Malyshkina, Anna I., Natalia Y. Sotnikova, Dmitriy N. Voronin, and Alena V. Kust. "Regulation of the functional activity of peripheral B lymphocytes in pregnant women with a history of recurrent miscarriage." Journal of obstetrics and women's diseases 70, no. 4 (2021): 73–79. http://dx.doi.org/10.17816/jowd62675.

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BACKGROUND:The frequency of recurrent miscarriage is up to 5 % of all desired pregnancies and is mainly due to immunological disorders. Dysfunction in the regulation of the functional activity of B lymphocytes is the pathogenetic link in multiple obstetric complications, including habitual miscarriage. AIM:The aim of this study was to characterize the regulation of the functional activity of peripheral B lymphocytes in pregnant women with threatened spontaneous miscarriage and a history of habitual miscarriage. MATERIALS AND METHODS:We examined 88 women aged 18-40 years at a gestat

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Kareem, Hiran J., and Abdulhassan, I. A. "The Role of ACE Gene Rs 1799752 I/D Polymorphism and Serum ACE Activity in Recurrent Miscarriage Pathogenesis in Iraqi Women." Journal of Neonatal Surgery 14, no. 1S (2025): 618–27. https://doi.org/10.52783/jns.v14.1586.

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Background Recurrent miscarriage is a major health public health problem that affects one to three percentage of women of childbearing age and is diagnosed as a spontaneous miscarriage if happened more than two times and occur often to the completion of 20 weeks amenorrhea. The variation in Angiotensin-Converting Enzyme (ACE) may be have an important role in the recurrent miscarriages (RM) in Iraqi women. Objective The present study aimed to investigate the role of ACE gene polymorphism and its serum level in the pathogenesis of recurrent miscarriage in Iraqi women. Materials and methods: Bloo

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