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Journal articles on the topic 'Red blood cell (RBC) antibodies'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Beerlage, Astrid, Joerg Halter, Sabine Gerull, et al. "Red Blood Cell Allo-Antibodies after Allogeneic Hematopoietic Stem Cell Transplantation." Blood 132, Supplement 1 (2018): 2551. http://dx.doi.org/10.1182/blood-2018-99-116237.

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Abstract Introduction Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) may require red blood cell (RBC) transfusions. AB0 blood group barrier is the clinically most important RBC group in transfusion medicine and HSCT and patients always receive AB0 compatible RBC transfusions. Some patients however develop allo-antibodies against minor RBC antigens. To date there is only limited information about the specificity, immuniser and risk factors for the development of RBC allo-antibodies. In this retrospective single centre study we aimed to identify specificities, risk

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2

Jajosky, Ryan, Connie Arthur, Jerry Allen, et al. "CD47 Regulates Red Blood Cell Alloimmunization in Mice." Blood 134, Supplement_1 (2019): 100. http://dx.doi.org/10.1182/blood-2019-131598.

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Background: Exposure to red blood cell (RBC) alloantigens during pregnancy or transfusion can lead to the development of alloantibodies and result in transfusion-related complications, including hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. However, the factors that regulate RBC alloimmunization remain incompletely understood. Several studies suggest that alterations in factors that regulate RBC clearance may impact RBC uptake and antigen presentation, directly influencing the likelihood of RBC alloimmunization. To test this, we directly examined the potential

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Balbuena-Merle, Raisa, Ronald G. Hauser, Matthew Karafin, et al. "The Presence and Persistence of Pregnancy-Associated Red Blood Cell Alloantibodies in Blood Donors." Blood 134, Supplement_1 (2019): 2452. http://dx.doi.org/10.1182/blood-2019-121388.

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Background: Females have higher RBC alloantibody prevalence than males, presumably due to exposure to non-self RBC antigens through pregnancy as well as transfusion. Given the lack of routinely available and longitudinal data on lifelong pregnancy and transfusion histories, few studies have been able to distinguish pregnancy versus transfusion as contributing risk factors for RBC alloantibody induction or for the persistence of RBC alloantibody detectability. We hypothesized that pregnancy would be an important source of persistently detected RBC alloantibodies and investigated this in a longi

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4

Zabeida, Alexandra, Nancy Robitaille, Marc Lebel, and Christian Renaud. "Reevaluating Immunization Delays Post Red Blood Cell Transfusion." Paediatrics & Child Health 23, suppl_1 (2018): e58-e58. http://dx.doi.org/10.1093/pch/pxy054.147.

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Abstract BACKGROUND Current Canadian guidelines recommend to delay the measles, mumps, rubella (MMR) and varicella live attenuated vaccines by 6 months following transfusion of unwashed red blood cells (RBC) due to potential interference by serum antibodies. Thus, patients chronically transfused with RBC commonly suffer from a delay or absence of MMR and varicella vaccination. Over the last decades, not only has RBC handling changed, but also fewer blood donors have had natural mumps, measles and rubella infections, resulting in lower blood antibody levels. The recommendations may thus be unfo

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Maier, Cheryl L., Ryan Jajosky, Hans Verkerke, et al. "Storage Differentially Impacts Immunization to Red Cell Antigens." Blood 138, Supplement 1 (2021): 3239. http://dx.doi.org/10.1182/blood-2021-152670.

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Abstract Introduction: The impact of red blood cell (RBC) storage on alloimmunization rates after transfusion remains controversial, with clinical experience demonstrating conflicting results. Indeed, some reports suggest increased rates of alloimmunization associated with longer storage of RBC units, while others suggest no association between alloimmunization rates and length of storage. We hypothesized that this discrepancy may reflect the differential impact of storage on alloimmunization related to each unique antigen and the immune response elicited. Here we define the effect of red cell

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Quist, Erin, and Scott Koepsell. "Autoimmune Hemolytic Anemia and Red Blood Cell Autoantibodies." Archives of Pathology & Laboratory Medicine 139, no. 11 (2015): 1455–58. http://dx.doi.org/10.5858/arpa.2014-0337-rs.

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Autoimmune hemolytic anemia is a rare disorder caused by autoreactive red blood cell (RBC) antibodies that destroy RBCs. Although autoimmune hemolytic anemia is rare, RBC autoantibodies are encountered frequently and can complicate transfusion workups, impede RBC alloantibody identification, delay distribution of compatible units, have variable clinical significance that ranges from benign to life-threatening, and may signal an underlying disease or disorder. In this review, we discuss the common presenting features of RBC autoantibodies, laboratory findings, ancillary studies that help the pa

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7

Makarovska-Bojadzjieva, Tatjana, Emilija Velkova, and Milenka Blagoevska. "The Impact of Extended Typing On Red Blood Cell Alloimmunization in Transfused Patients." Open Access Macedonian Journal of Medical Sciences 5, no. 2 (2017): 107–11. http://dx.doi.org/10.3889/oamjms.2017.054.

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BACKGROUND: Red blood cell (RBC) alloimmunization is still an actual problem in our transfusion practice. In 2011, in addition to the regular ABO/D blood group typing, phenotyping for Rh (C, c, E, e) and Kell antigens was introduced for blood donors and patients undergoing blood transfusion. Our aim was to evaluate the impact of the extended RBC typing and donor/recipient matching on the incidence of RBC alloimmunization.METHODS: A retrospective comparative study was conducted by reviewing RBC request records for about 36,000 patients transfused with RBC in the period from 2013 to 2015 in comp

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8

Rofinda, Zelly Dia, and Yashinta Octavian Gita Setyanda. "Screening and Identification of Erythrocyte Antibodies: A Narrative Literature Review." Bioscientia Medicina : Journal of Biomedicine and Translational Research 8, no. 10 (2024): 5094–108. http://dx.doi.org/10.37275/bsm.v8i10.1091.

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Red blood cell (RBC) alloimmunization, the development of antibodies against foreign red blood cell antigens, is a critical concern in transfusion medicine. Alloantibodies can lead to adverse transfusion reactions, including hemolytic disease of the fetus and newborn (HDFN) and delayed hemolytic transfusion reactions (DHTR). This comprehensive literature review explores the intricacies of RBC alloimmunization, focusing on the screening and identification of erythrocyte antibodies. We delve into the prevalence and clinical significance of various alloantibodies, the underlying immunological mec

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9

Bendix, Brenda J., Eapen K. Jacob, Sara M. Barnes, et al. "Transfusion Reaction and Red Cell Antibody Formation in Allogeneic Hematopoietic Progenitor Cell Transplantation Recipients." Blood 126, no. 23 (2015): 3573. http://dx.doi.org/10.1182/blood.v126.23.3573.3573.

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Abstract Background: Little data exists on the incidence rate of transfusion reactions and red cell antibody formation following allogeneic (allo) hematopoietic progenitor cell transplant (HPCT) recipients. Study Design and Methods: Consecutive related and unrelated Allogeneic HPCTs from 2006 to 2013 were retrospectively reviewed regardless of graft source. Allo HPCT recipients were analyzed as a whole as well as divided into ABO compatibility groups of identical, minor mismatch, and major/bidirectional mismatch. Transfusions, transfusion reactions and antibodies were analyzed for the first ye

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10

Chapuy, Claudia I., Richard M. Kaufman, Edwin P. Alyea, and Jean M. Connors. "Daratumumab for Delayed Red Cell Engraftment after Hematopoietic Stem Cell Transplant." Blood 132, Supplement 1 (2018): 2545. http://dx.doi.org/10.1182/blood-2018-99-111880.

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Abstract Allogeneic stem cell transplantation represents a curative treatment option for patients with malignant hematologic diseases, including myelodysplastic syndrome (MDS). In 25-50% of transplants, HLA-matched allogeneic stem cell donors have some degree of ABO incompatibility with the recipient. Major ABO incompatibility is caused by recipient antibodies directed against donor red blood cells (RBCs) and may lead to delayed RBC recovery and transient pure red cell aplasia (PRCA). We describe a case of treatment-refractory pure red cell aplasia following a major ABO-mismatchedallogeneic st

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11

VR, Muzykantov, and Murciano JC. "Attachment of antibody to biotinylated red blood cells: immuno‐red blood cells display high affinity to immobilized antigen and normal biodistribution in rats." Biotechnology and Applied Biochemistry 24, no. 1 (1996): 41–45. http://dx.doi.org/10.1111/j.1470-8744.1996.tb00386.x.

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Streptavidin‐mediated attachment of biotinylated antibodies (b‐Ab) to biotinylated red blood cells (b‐RBC) is useful for preparation of immuno‐red blood cells, a prospective vehicle for drug targeting. However, streptavidin (SA) induces lysis of extensively biotinylated RBC by complement due to cross‐linking and inactivation of RBC complement regulators. To reduce cross‐linking of RBC membrane proteins, we utilized mild biotinylation of RBC with 20 microM biotin ester (b20‐RBC). SA effectively binds to rat b20‐RBC (10(5) SA molecules/cell) and provides for following attachment of 5 times 10(4)

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12

Butler, Dakota D., David A. Hundley, Ha Y. Lin, et al. "Blood Management in a Liver Transplant Recipient with Kidd (Jka) and Rhesus (D) Antibodies: A Case Report." A&A Practice 18, no. 4 (2024): e01769. http://dx.doi.org/10.1213/xaa.0000000000001769.

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A 67-year-old man presented for urgent liver transplantation (LT). Screening revealed the rare combination of antiRhesus (D) and antiKidd Jk(a) antibodies, requiring antigen-negative red blood cells (RBC) for both phenotypes. This combination has not been reported during LT. Compatible RBCs were initially limited, requiring continued communication between the blood bank/blood supplier to obtain more, including frozen, units. Additional strategies included the use of cell salvage and intentional management of coagulopathy to limit bleeding and RBC requirement. This case highlights blood managem

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13

Calabro, Samuele, Antonia Gallman, Uthaman Gowthaman, et al. "Bridging channel dendritic cells induce immunity to transfused red blood cells." Journal of Experimental Medicine 213, no. 6 (2016): 887–96. http://dx.doi.org/10.1084/jem.20151720.

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Red blood cell (RBC) transfusion is a life-saving therapeutic tool. However, a major complication in transfusion recipients is the generation of antibodies against non-ABO alloantigens on donor RBCs, potentially resulting in hemolysis and renal failure. Long-lived antibody responses typically require CD4+ T cell help and, in murine transfusion models, alloimmunization requires a spleen. Yet, it is not known how RBC-derived antigens are presented to naive T cells in the spleen. We sought to answer whether splenic dendritic cells (DCs) were essential for T cell priming to RBC alloantigens. Trans

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Anwar, F., M. Almohammadi, A. Garni, S. Jamallail, W. Alsamkari, and A. Alsafi. "Red Blood Cell Alloimmunization in Sickle Cell Disease: Advantage of Ethnic Heritage between Donors and Patients in Jeddah, Saudi Arabia." American Journal of Clinical Pathology 156, Supplement_1 (2021): S157. http://dx.doi.org/10.1093/ajcp/aqab191.335.

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Abstract Introduction/Objective Red blood cell (RBC) transfusion is frequently required for patients with sickle cell disease (SCD). Development of alloantibodies in these patients complicates the blood bank process needed to identify these antibodies and to find compatible RBC units. The rate of alloimmunization has been reported as high as 47% in one study and 34.2% in another study from Eastern region of Saudi Arabia. The purpose of this study was to determine incidence and rate of RBC alloimmunization in the Saudi population in the Western region in SCD. Methods/Case Report A retrospective

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15

Gruber, David R., Amanda L. Richards, Heather L. Howie, et al. "Passively transferred IgG enhances humoral immunity to a red blood cell alloantigen in mice." Blood Advances 4, no. 7 (2020): 1526–37. http://dx.doi.org/10.1182/bloodadvances.2019001299.

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Abstract Antibodies are typically thought of as the endpoint of humoral immunity that occur as the result of an adaptive immune response. However, affinity-matured antibodies can be present at the initiation of a new immune response, most commonly because of passive administration as a medical therapy. The current paradigm is that immunoglobulin M (IgM), IgA, and IgE enhance subsequent humoral immunity. In contrast, IgG has a “dual effect” in which it enhances responses to soluble antigens but suppresses responses to antigens on red blood cells (RBCs) (eg, immunoprophylaxis with anti-RhD). Her

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16

Khan, Ramsha, Melissa Menard, Chao-Ching Jen, Xi Chen, Peter A. A. Norris, and Alan H. Lazarus. "Inhibition of platelet phagocytosis as an in vitro predictor for therapeutic potential of RBC antibodies in murine ITP." Blood 135, no. 26 (2020): 2420–24. http://dx.doi.org/10.1182/blood.2019003646.

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Abstract Polyclonal anti-D is a first-line therapy for immune thrombocytopenia (ITP). Monoclonal antibodies are desirable alternatives, but none have yet proven successful despite their ability to opsonize erythrocytes (or red blood cells, RBCs) and cause anemia. Here, we examined 12 murine erythrocyte–specific antibodies of different specificity and subtypes and found that 8 of these antibodies could induce anemia in antigen-positive mice. Of these 8 antibodies, only 5 ameliorated ITP. All antibodies were examined for their in vitro ability to support macrophage-mediated phagocytosis of eryth

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17

Fernandes, Heloise Pockel, Adriana Fontes, André A. Thomaz, et al. "Sensitive and Simple Methodologies for Measuring of Red Blood Cell (RBC) Electrical Properties and Cell Aggregation." Blood 112, no. 11 (2008): 998. http://dx.doi.org/10.1182/blood.v112.11.998.998.

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Abstract The red blood cell membrane contains proteins and glycoproteins embedded in a fluid lipid bilayer that confers viscoelastic behaviour. Sialylated glycoproteins of the RBC membrane are responsible for a negatively charged surface, which creates a repulsive electric zeta potential (ζ) between the cells. The compact layer of charge or Stern consists of ions rigidly bonded to the cell and the double layer includes ions diffusely distributed around the cell. Measurement of RBC layer of charge and zeta potential can be use as a marker of RBC membrane injury. Study of membrane electrical pro

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Asante, Akua, Kelly Henrichs, Neil Blumberg, and Tanzy Love. "Red Cell Alloimmunization Rate in Patients with Sickle Cell Disease." Blood 144, Supplement 1 (2024): 5605. https://doi.org/10.1182/blood-2024-205867.

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Background: Sickle cell disease(SCD) is a single gene disorder resulting in dysfunctional hemoglobin tetramers that polymerize causing vaso-occlusion (VOC), hemolysis, endothelial damage and inflammation leading to pain and end-organ damage. Red blood cell (RBC) transfusions are vital despite recent advances in treatment. RBC alloimunization complicates treatment with rates of up to 47% limiting availability of compatible RBC units. The etiology of alloimmunization is multifactorial; including donor recipient racial differences, transfusion volume, non-leukoreduced RBCs, infection or VOC durin

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Zimring, James C., Gregory A. Hair, Traci E. Chadwick, et al. "Nonhemolytic antibody-induced loss of erythrocyte surface antigen." Blood 106, no. 3 (2005): 1105–12. http://dx.doi.org/10.1182/blood-2005-03-1040.

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Abstract Transfusion of red blood cells (RBCs) into patients with anti–donor RBC antibodies (crossmatch-incompatible transfusion) can result in lethal antibody-mediated hemolysis. Less well appreciated is the ability of anti-RBC antibodies to specifically remove their target antigen from donor RBCs without compromising cell survival or adversely affecting the transfusion recipient. In an effort to elucidate the mechanistic details of this process, we describe the first animal model of nonhemolytic antibody-induced RBC antigen loss. RBCs from transgenic mHEL mice express surface hen egg lysozym

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20

Wu, Shujie, Yinglin Wu, Ganping Guo, Rungui Xie, and Yuanjun Wu. "Comparison of the Detection Rate and Specificity of Irregular Red Blood Cell Antibodies Between First-Time Pregnant Women and Women With a History of Multiple Pregnancies Among 18,010 Chinese Women." Journal of Pregnancy 2024 (May 31, 2024): 1–6. http://dx.doi.org/10.1155/2024/5539776.

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Background: There is insufficient evidence to assess the risk of the production of clinically important alloimmune irregular red blood cell (RBC) antibodies in first-time pregnant women.Methods: Using the microcolumn gel antiglobulin method, 18,010 Chinese women with a history of pregnancy and pregnant women were screened for irregular RBC antibodies, and for those with positive test results, antibody specificity was determined. The detection rate and specificity of irregular RBC antibodies in women with a history of multiple pregnancies (two or more) and first-time pregnant women were determi

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Clement D, Okello, Shih Andrew W, Nabwana Martin, et al. "Frequency of red blood cell allo-immunization in patients undergoing blood transfusion at the Uganda Cancer Institute." African Health Sciences 23, no. 4 (2023): 362–70. http://dx.doi.org/10.4314/ahs.v23i4.39.

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Background: There is limited data on red blood cell (RBC) alloimmunization in patients with cancer in sub-Saharan Africa (SSA). We examined the frequency of RBC alloimmunization in transfused patients with cancers in Uganda.Methods: A randomized control trial was conducted on participants at the Uganda Cancer Institute. Eligible participants were age ≥15 years and required blood transfusion. Participants were randomized to receive either leucoreduced or non-leucoreduced blood transfusion. Participants’ plasma samples were screened for RBC alloantibodies at enrolment and 3-4 weeks after blood t

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Bujandric, Nevenka, Jasmina Grujic, and Zorana Budakov-Obradovic. "Red blood cell alloimmunization in pregnancy: A 10-year single-centre study." Vojnosanitetski pregled, no. 00 (2021): 16. http://dx.doi.org/10.2298/vsp201124016b.

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Background/Aim. Pregnancy-induced red blood cell (RBC) alloimmunization is important not only because of the possible negative effects on subsequent pregnancy outcomes, in case the fetus carries the antigen, but also because of the optimal transfusion management in cases of obstetric haemorrhage. Timely detection of RBC antibodies is part of a testing, prevention and treatment strategy aimed at achieving better outcomes for alloimmunized mothers with an affected fetus. The aim was to determine the frequency and specificity of alloantibodies among pregnant women from the South Backa District, w

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Dean, Melinda M., Ju Ji, YuanTong Gu, Emilie Sauret, and Robert L. Flower. "Visualising interaction of monocytes with red blood cells (RBC) sensitised with “clinically significant” antibodies." Journal of Immunology 202, no. 1_Supplement (2019): 58.16. http://dx.doi.org/10.4049/jimmunol.202.supp.58.16.

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Abstract Background Anti-RBC antibodies in plasma are regarded as clinically significant when they promote clearance of transfused RBC by monocytes/macrophages. To date, processes involved in the attachment or phagocytosis of sensitised RBC by monocytes have been investigated using light or fluorescent microscopy. We used scanning electron microscopy (SEM) to facilitate a closer examination of the interaction between monocytes and RBCs sensitised with antibodies of specificities classified as clinically significant. Methods Peripheral blood mononuclear cells (PBMC) were seeded onto glass cover

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Campbell-Lee, Sally A., Jinhuan Liu, Paul M. Ness, and William M. Baldwin. "Red Blood Cell Alloimmunization Is Affected by Depletion of Donor White Cell Subsets." Blood 110, no. 11 (2007): 456. http://dx.doi.org/10.1182/blood.v110.11.456.456.

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Abstract Red blood cell (RBC) alloimmunization leads to therapeutic limitations due to difficulties in obtaining compatible RBC components. Better understanding of immune mechanisms responsible for alloantibody formation are necessary in order to develop ways of preventing or treating alloimmunization in high risk patients. A murine model of RBC alloimmunization was developed using B6CBA-F1-Tg Fyb mice that express the human Fyb blood group as donors, and recipient mice of the B6CBA-F1 strain. RBC were obtained from donor mice that were anesthetized and exsanguinated by cardiac puncture. Donor

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Girard-Pierce, Kathryn R., Sean R. Stowell, Nicole H. Smith, et al. "A novel role for C3 in antibody-induced red blood cell clearance and antigen modulation." Blood 122, no. 10 (2013): 1793–801. http://dx.doi.org/10.1182/blood-2013-06-508952.

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Key Points Transfused murine RBCs expressing the KEL2 antigen induce polyclonal anti-KEL glycoprotein antibodies capable of fixing complement. Complement plays a role in incompatible RBC clearance and modulation of the KEL2 antigen on transfused RBCs.

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Nguyen, Toan D., Brandon M. Bordeau, Yu Zhang, Anna G. Mattle, and Joseph P. Balthasar. "Half-Life Extension and Biodistribution Modulation of Biotherapeutics via Red Blood Cell Hitch-Hiking with Novel Anti-Band 3 Single-Domain Antibodies." International Journal of Molecular Sciences 24, no. 1 (2022): 475. http://dx.doi.org/10.3390/ijms24010475.

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Small therapeutic proteins are receiving increased interest as therapeutic drugs; however, their clinical success has been limited due to their rapid elimination. Here, we report a half-life extension strategy via strategy via red blood cell red blood cell (RBC) hitch-hiking. This manuscript details the development and characterization of novel anti-RBC single-domain antibodies (sdAbs), their genetic fusion to therapeutic antibody fragments (TAF) as bispecific fusion constructs, and their influence on TAF pharmacokinetics and biodistribution. Several sdAbs specific to the band 3 antigen were g

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Kaul, DK, EF Jr Roth, RL Nagel, RJ Howard, and SM Handunnetti. "Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions." Blood 78, no. 3 (1991): 812–19. http://dx.doi.org/10.1182/blood.v78.3.812.812.

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Abstract The occurrence of rosetting of Plasmodium falciparum-infected human red blood cells (IRBC) with uninfected red blood cells (RBC) and its potential pathophysiologic consequences were investigated under flow conditions using the perfused rat mesocecum vasculature. Perfusion experiments were performed using two knobby (K+) lines of P falciparum, ie, rosetting positive (K+R+) and rosetting negative (K+R-). The infusion of K+R+ IRBC resulted in higher peripheral resistance (PRU) than K+R- IRBC (P less than .0012). Video microscopy showed that under conditions of flow, in addition to cytoad

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Kaul, DK, EF Jr Roth, RL Nagel, RJ Howard, and SM Handunnetti. "Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions." Blood 78, no. 3 (1991): 812–19. http://dx.doi.org/10.1182/blood.v78.3.812.bloodjournal783812.

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The occurrence of rosetting of Plasmodium falciparum-infected human red blood cells (IRBC) with uninfected red blood cells (RBC) and its potential pathophysiologic consequences were investigated under flow conditions using the perfused rat mesocecum vasculature. Perfusion experiments were performed using two knobby (K+) lines of P falciparum, ie, rosetting positive (K+R+) and rosetting negative (K+R-). The infusion of K+R+ IRBC resulted in higher peripheral resistance (PRU) than K+R- IRBC (P less than .0012). Video microscopy showed that under conditions of flow, in addition to cytoadherence o

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Aung, Fleur M., Virgil M. Reddy, and Benjamin Lichtiger. "The Benefit of RED CELL Antigen Testing in A Transfusion Service of A Large Cancer Center." Blood 120, no. 21 (2012): 4374. http://dx.doi.org/10.1182/blood.v120.21.4374.4374.

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Abstract Abstract 4374 Introduction: DNA-based tests are increasingly being used to predict blood group phenotypes in patients who have been recently transfused to aid in alloantibody identification, to distinguish an alloantibody from an autoantibody, in patients who have received hematopoietic stem cell transplants, when RBCS are coated with immunoglobulin (+DAT) and to detect weakly expressed antigens when the patient is unlikely to make antibodies to antigen- positive RBC's transfused. The molecular bases associated with most antigens have been determined and PCR-assays available for testi

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Uyoga, Sophie, Michael Muteti, Johnstone Makale, George Mochamah, Russell E. Ware, and Thomas N. Williams. "RED Blood Cell Alloimmunization in Sickle Cell Anaemia Patients in Kilifi, Kenya." Blood 144, Supplement 1 (2024): 5602. https://doi.org/10.1182/blood-2024-206754.

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Background: Sickle cell anaemia (SCA) patients rely on transfusions as an intervention for management of their disease. In Kenya, matching of blood between donors and recipients is only performed for major ABO and Rhesus D antigens, without extended matching for clinically significant minor blood groups. Similarly, although cross matching is done before blood is issued, routine screening for red blood cell (RBC) alloantibodies, which increase the risk of haemolytic transfusion reactions, is not performed. Both the WHO and the American Society of Hematology recommend that RBC antigen profiling

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Obeidi, Narges, Samad AkbarZadeh, and Mankhian Ali Reza. "Red Blood Cell (RBC) Phenotyping in Major Thalassemia Patients in Bushehr." International Journal of Sciences Volume 3, no. 2014-04 (2014): 83–85. https://doi.org/10.5281/zenodo.3348677.

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Background: RBC phenotyping is essential to confirm the identity of suspected alloantibodies and to facilitate the identification of antibodies that may be formed in the future. We tested the phenotype detection of A, B, C, c, D, E, e, Lea, Leb, K, Fya, Fyb, Jka, Jkb, M, N, S, s and P1antigens in the peripheral blood samples. Methods: RBC phenotyping in 72 transfused thalassemia patients were evaluated in Fatemeh Zahra Hospital in Bushehr in a cross-sectional study. K2-EDTA-anticoagulated blood samples were obtained for RBC antigen detection. Red cell antigens were detected using standard bloo

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Prokopchuk-Gauk, Oksana, Nicole L. Prokopishyn, Joanna McCarthy, and Meer-Taher Shabani-Rad. "Red Cell Alloimmunization Rates in Allogeneic Hematopoietic Stem Cell Transplant Recipients." Blood 128, no. 22 (2016): 3402. http://dx.doi.org/10.1182/blood.v128.22.3402.3402.

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Abstract Introduction: Donor selection for allogeneic hematopoietic stem cell transplant (allo-HSCT) is dependent on matching with the intended recipient HLA allele profile, but not blood group compatibility. Red blood cell (RBC) phenotype matching is not considered, even if recipient alloantibodies are present pre-HSCT. Historically, up to 3.7% of allo-HSCT recipients have been found to develop new RBC alloantibodies following allo-HSCT. We completed an audit of all adult and pediatric allo-HSCT recipients of the Alberta Bone Marrow and Blood Cell Transplant Program to define the rate of RBC

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Trompeter, Sara, Ana Bárbara Rodrigues Cavalcante, Marie Chion, et al. "The Pattern of Red Cell Antibodies in a Large Population of People with Sickle Cell Disease and Thalassemia." Blood 142, Supplement 1 (2023): 1289. http://dx.doi.org/10.1182/blood-2023-188531.

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Background There is interest in strategies to match recipients to red blood cell (RBC) units for transfusion using antigens beyond ABO/Rh/K with the aim of reducing rates of alloantibody formation in heavily transfused people, for example sickle cell disease (SCD) and thalassemia (THAL). However, the efficacy of different strategies, often defined in national guidelines, is unknown. People with SCD/THAL in England are now offered free universal blood group typing using high-throughput, low-cost genotyping arrays, which will also be applied to 92,000 blood donors, extending the antigens availab

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Dinić, Radovan, Nevenka Bujandrić, and Jasmina Grujić. "Prevalence and Specificity of Red Blood Cell Alloimmunization: Insights from Transfusion-Dependent Populations in Serbia." Thalassemia Reports 15, no. 2 (2025): 5. https://doi.org/10.3390/thalassrep15020005.

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Background/Objectives: Red blood cell (RBC) alloimmunization is a significant challenge in transfusion medicine, particularly among transfusion-dependent patients, such as those with thalassemia. It arises from the production of antibodies against non-self RBC antigens and can lead to complications like hemolytic transfusion reactions. This study aimed to evaluate the prevalence, specificity, and clinical implications of RBC alloimmunization at the University Clinical Center of Serbia (UCCS), emphasizing transfusion-dependent populations. Methods: This retrospective study analyzed 27,530 trans

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Dutt, Neeti, Sushil Sharma, and Meena Sidhu. "Red cell alloimunization and autoantibodies in transfusion dependent thalassemia patients of Jammu region." International Journal of Advances in Medicine 9, no. 2 (2022): 95. http://dx.doi.org/10.18203/2349-3933.ijam20220115.

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Background: Thalassemia is one of the most common genetic disorder of hemoglobin synthesis in Jammu region. Although RBC transfusion is life saving for these patients, it may be associated with some complications like RBC alloimmunization. Thus, alloimmunization against red blood cell antigens increases the need for transfusion and can significantly complicate transfusion therapy. Therefore, screening for unexpected antibodies should be a part of all pretransfusion testing, with antibody identification in the event of a positive result. The aim of the study was to determine the frequency of al

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Hendrickson, Jeanne E., Traci E. Chadwick, John D. Roback, Christopher D. Hillyer, and James C. Zimring. "Host Inflammation Increases Alloimmunization to Transfused Red Blood Cells." Blood 106, no. 11 (2005): 1887. http://dx.doi.org/10.1182/blood.v106.11.1887.1887.

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Abstract Background: Alloimmunization to RBC is a serious sequelae of transfusion, which can result in hemolytic transfusion reactions and difficulty identifying compatible units for future transfusion. Although any given unit of RBC contains numerous alloantigens, only 6% of transfusion recipients mount a measurable alloantibody response. The factors that determine whether a given transfusion recipient will generate antibodies remains undetermined. Activation of the innate immune system through inflammation is known to have a significant effect on immune responses in other settings. According

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Mukai, Masaya, Akira Sagawa, Isao Sakai, et al. "Enzyme linked immunosorbent assay for detection of anti-red blood cell(RBC) antibodies using RBC ghost protein." Japanese Journal of Clinical Immunology 11, no. 3 (1988): 276–82. http://dx.doi.org/10.2177/jsci.11.276.

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Lukito, Pohan, Lanny Ramadi, Jenny Condon, Ni Ni Aung, Chris Hogan, and Marija Nedeljkovic. "Changing patterns in rare red blood cell (RBC) phenotypes, and antibodies – results from melbourne RBC reference laboratory." Pathology 47 (2015): S90—S91. http://dx.doi.org/10.1097/01.pat.0000461588.91050.ff.

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39

Zerra, Patricia E., Seema R. Patel, Ryan Philip Jajosky, et al. "Marginal zone B cells mediate a CD4 T-cell–dependent extrafollicular antibody response following RBC transfusion in mice." Blood 138, no. 8 (2021): 706–21. http://dx.doi.org/10.1182/blood.2020009376.

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Abstract Red blood cell (RBC) transfusions can result in alloimmunization toward RBC alloantigens that can increase the probability of complications following subsequent transfusion. An improved understanding of the immune mechanisms that underlie RBC alloimmunization is critical if future strategies capable of preventing or even reducing this process are to be realized. Using the HOD (hen egg lysozyme [HEL] and ovalbumin [OVA] fused with the human RBC antigen Duffy) model system, we aimed to identify initiating immune factors that may govern early anti-HOD alloantibody formation. Our findings

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Schott, Nicholas J., Mark H. Yazer, Robert Krohner, and Jonathan H. Waters. "Failure of Intraoperative Red Cell Salvage: A Patient with Sickle Cell Disease and HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) Syndrome." Journal of ExtraCorporeal Technology 46, no. 4 (2014): 314–16. http://dx.doi.org/10.1051/ject/201446314.

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Cell salvage is a process whereby the bloodshed from the operative field is collected and returned to the patient. It can be especially useful when allogeneic red blood cell (RBC) units are not readily available such as when the recipient has multiple alloantibodies. We report on the anesthesia and transfusion strategies for managing a pregnant patient with sickle cell disease (SCD) with HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome. A pregnant patient with twins at 30 weeks of gestation was admitted in an SCD crisis. She subsequently developed HELLP syndrome and require

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41

Mobasheri, Leila, Tayyebeh Chahkandi, Amir Talebpour, and Gholamreza Anani Sarab. "Red blood cell alloimmunization among transfusion-dependent thalassemia major patients in Northeastern Iran." Asian Journal of Transfusion Science 18, no. 2 (2022): 214–18. https://doi.org/10.4103/ajts.ajts_107_21.

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Abstract BACKGROUND: Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran. METHODS: For the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases

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Spooner, Michaela, Joanne Yu, Thomas Wiseman, et al. "Extended Rhesus and Kell Phenotype-Matched Red Blood Cell (RBC) Transfusions Reduce RBC Alloimmunization and RBC Transfusion Burden in Patients with Myeloid Neoplasm." Blood 144, Supplement 1 (2024): 5593. https://doi.org/10.1182/blood-2024-212000.

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Background: Up to 90% of patients with myelodysplastic syndrome (MDS) require red blood cell (RBC) transfusions and 11-14% of RBC-transfused patients develop RBC alloantibodies (Singhal et al., Haematologica 2017; Chhetri et al., Haematologica 2019), most commonly against Rhesus (Rh) and Kell (K). RBC alloimmunisation can trigger RBC autoantibody formation which, in turn, can lead to bystander hyperhaemolysis of autologous RBC and increases RBC transfusion requirements. Method: Patients with primary MDS and acute myeloid leukemia (AML) enrolled in the SA Myeloid Neoplasm registry with at least

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Wautier, Jean-Luc, Pierre Gane, Wassim El Nemer, Jean-Dider Rain, Caroline Le Van Kim, and Marie-Paule Wautier. "Increased Adhesion of Red Blood Cells from Patients with Polycythemia Vera Is Mediated by Lu/B-CAM and Laminin alpha 5." Blood 106, no. 11 (2005): 3527. http://dx.doi.org/10.1182/blood.v106.11.3527.3527.

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Abstract Polycythemia vera (PV) is associated to a high risk of vascular thrombosis which is related to red blood cell (RBC) volume and platelet activation. We have investigated whether, beside high hematocrit, RBCs exhibit qualitative abnormalities. Along this line we have measured RBC adhesion to human umbilical vein endothelial cell (HUVEC) under static and flow conditions. A group of 38 PV patients and one of 36 normal subjects were explored. Adhesion molecule expression using specific antibodies (anti-CD36, CD49d, ICAM-4, Lu/B-CAM, CD147, CD47) and flow cytometry were determined on RBCs.

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Smith, Louise, Lucy Stead, Russell D. Keenan, and Rekha Thangavelu. "Minimising Transfusion Therapy and Alloimmunisation in Patients with Sickle Cell Disorder in the Era of Hydroxyurea." Blood 132, Supplement 1 (2018): 5078. http://dx.doi.org/10.1182/blood-2018-99-119837.

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Abstract In the UK, 700 patients with sickle cell disease are on a transfusion programme1. Red blood cell (RBC) AI occurs in 4.4-76%2 of regularly transfused sickle patients. Contributing factors include repeated transfusions and ethnic differences between sickle cell patients and their donors. This results in higher rates of mismatch in phenotyped and genotyped blood. There is a continued lack of availability of blood products from more compatible ethnic donors. Sickle patients on transfusion programmes are transfused every 3-6 weeks, creating a large burden on healthcare services in terms of

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Panigaj, Martin, Adela Brouckova, Hana Glierova, and Karel Holada. "Expression of Cellular Prion Protein (PrPc) on Human Red Blood Cells." Blood 106, no. 11 (2005): 1898. http://dx.doi.org/10.1182/blood.v106.11.1898.1898.

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Abstract Two recent UK cases of vCJD transmission by blood transfusion emphasize urgent need of donor screening test for prion diseases. Pathological form of prion protein, PrPsc, is currently the only specific marker of prion diseases, but its detection in blood poses significant challenge. Blood contains substantial amount of normal PrPc which supposedly differs from PrPsc only in its conformation. Majority of cell associated PrPc in blood reside in platelets (PLT). PrPc is also expressed on PBMCs, but their contribution to quantity of blood PrPc is small. The situation is less clear with Pr

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Nahendran, Prasanthini, Siti Balkis Budin, Nur Zakiah Mohd Saat, Mohd Faeiz Yusop, Tengku Norita Tengku Yazid, and Nur Najmi Mohamad Anuar. "Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang." Asian Journal of Transfusion Science 18, no. 2 (2023): 286–90. https://doi.org/10.4103/ajts.ajts_75_22.

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Abstract BACKGROUND: Transfusion support is vital for the management of patients with hepatobiliary disease. Repeated blood transfusions increase the risk of alloimmunization, i.e., the development of alloantibodies, which might lead to difficulties in blood crossmatching. AIMS: This study aims to: (1) determine the incidence of red blood cell (RBC) alloimmunization and (2) evaluate the associations between antibody development and demographic factors among hepatobiliary patients. METHOD: ABO blood grouping, antibody screening, antibody identification and crossmatch were done on all patients s

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Salman, A. Rawas, Y. Alzahrani Hassan, F. Alharbi Abrar, A. Jusstaniah Mohammed, F. Alharbi Rawan, and Andejani Wala. "Impact of Extended Red Blood Cell Antigen Typing on Alloimmunization in Multi-Transfused Patients: A Retrospective Study." International Journal on Science and Technology 16, no. 1 (2025): 1–10. https://doi.org/10.5281/zenodo.15222887.

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Background: Alloimmunization is a complication of blood transfusion in which the recipient forms antibodies against the foreign antigens on the donor’s red blood cells (RBC), and it poses great difficulty in subsequent transfusion needs. Multi-transfused patients have an increased risk of RBC alloimmunization. Its adverse effects have led to the consideration of more advanced antigen matching for patients with a chronic need for transfusions.  Objective: To assess the effect of extended antigen typing on the extended prevalence of RBC alloimmunization among multi-transfused patients

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Abu Taha, Adham, Ahmad Yaseen, Sa’d Suleiman, et al. "Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine." Advances in Hematology 2019 (November 12, 2019): 1–5. http://dx.doi.org/10.1155/2019/3295786.

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Background. β-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal treatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of RBC alloimmunization among thalassemic patients in northern governorates of Palestine. Methods. A prospective multicenter observational study was conducted in the thalassemia transfusion centers in the northern governorates of Palestine. The study included 215 thalassemia patients who received regular blood transfusions. Clinical and transfus

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Kirk, James T., Kerry W. Lannert, Daniel M. Ratner, and Jill M. Johnsen. "Serologic and Phenotypic Analysis of Blood Types Via Silicon Nanophotonics." Blood 124, no. 21 (2014): 1565. http://dx.doi.org/10.1182/blood.v124.21.1565.1565.

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Abstract Tens of millions of donor and patient samples are tested yearly to establish blood type compatibility between donor and recipient and to protect recipients from blood-borne infectious diseases. Blood type testing, particularly donor testing, is traditionally based in centralized clinical laboratories. However, current blood typing methods are encumbered by reagent availability, cost, technical training requirements, and time, placing a costly burden on the medical system. To address practical needs in blood typing, we have developed a multiplexed blood analysis platform using a low-co

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Dean, Melinda M., Thu V. Tran, Yu Ji, et al. "Development of a Semi-automated Monocyte Monolayer Assay (MMA) to Determine the Clinical Significance of Red Cell Alloantibodies." Journal of Immunology 204, no. 1_Supplement (2020): 86.55. http://dx.doi.org/10.4049/jimmunol.204.supp.86.55.

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Abstract BACKGROUND One risk of allogeneic blood transfusion is the development of alloantibodies against red blood cell (RBC) antigens not found on the recipient’s RBC. The monocyte monolayer assay (MMA) is an in vitro model which has been used to determine the clinical significance of alloantibodies and predict post-transfusion RBC survival. We aimed to develop a semi-automated procedure to reduce assay time and facilitate improved patient management. METHODS PBMCs isolated using Sepmate tubes (STEMCELL Technologies) were added to Lab-Tek 8-well chamber slides (37°C, 1 hr, CO2). Antigen matc

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