Relevant bibliographies by topics / Reference-Free detected RNAs

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Reference-Free detected RNAs'

Author: Grafiati
Published: 25 May 2024
Last updated: 31 July 2025

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Journal articles on the topic "Reference-Free detected RNAs"

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Lee, Bongyong, Alisha Babu, Aiguo Zhang, and Michael Y. Sha. "Abstract 2191: Detection of actionable lung cancer fusion genes with known and novel partners from highly degraded FFPE material." Cancer Research 83, no. 7_Supplement (2023): 2191. http://dx.doi.org/10.1158/1538-7445.am2023-2191.

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Abstract Chromosomal rearrangements resulting in expression of oncogenic chimeric proteins drive tumor progression. Gene fusions are promising targets for cancer therapy in various types of cancers. Therefore, faithful detection of gene fusions is essential in precision medicine. Previously, fusions have been detected using FISH, RT-PCR and RNA-seq. Targeted sequencing provides better sensitivity as only the regions associated with the driver genes are sequenced, increasing possible coverage depth, and reducing cost. We developed a targeted RNA-based lung cancer fusion panel utilizing 5’ RACE
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Torossian, Nouritza, Dominika Foretek, Marc Gabriel, et al. "Abstract 2774: Reference free transcriptomic characterization of chemoresistant triple negative breast cancers provides a promising reservoir of predictive biomarkers of early chemoresistance." Cancer Research 82, no. 12_Supplement (2022): 2774. http://dx.doi.org/10.1158/1538-7445.am2022-2774.

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Abstract Triple Negative Breast Cancers (TNBCs) are the most aggressive breast cancers and so far, benefited very little from personalized medicine. Unlike in hormone positive breast cancers, coding transcriptomic signatures like Lehmann’s failed to predict which TNBC patients will benefit from perioperative chemotherapy. Here, we analyzed the total transcriptome of a unique cohort of 44 TNBC tumors before neoadjuvant chemotherapy (NAC), including both patients that were chemosensitive (N=26) and chemoresistant (N=18) to following treatment. Differential gene expression analysis (DE-seq) was f
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Spielmann, Nadine, Diane Ilsley, Jian Gu, et al. "The Human Salivary RNA Transcriptome Revealed by Massively Parallel Sequencing." Clinical Chemistry 58, no. 9 (2012): 1314–21. http://dx.doi.org/10.1373/clinchem.2011.176941.

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Abstract BACKGROUND Evaluation of the salivary transcriptome is an emerging diagnostic technology with discriminatory power for disease detection. This study explored massively parallel sequencing for providing nucleotide-level sequence information for each RNA in saliva. METHODS Transcriptome profiling with the SOLiD™ system was applied to RNA isolated from unstimulated cell-free saliva (CFS) and whole saliva (WS) from healthy human volunteers. Sequenced reads were aligned to human genome build 18 and the Human Oral Microbiome Database (HOMD). RESULTS Massively parallel sequencing enabled the
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Van Eijs, Mick J. M., Nicolette C. Notermans, Tom Würdinger, and Monique C. Minnema. "Platelet RNA Splicing Profiles Can Distinguish IgM MGUS Patients from Healthy Individuals." Blood 134, Supplement_1 (2019): 3771. http://dx.doi.org/10.1182/blood-2019-124325.

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Introduction Within the general population over 50 years, 3% is affected with a monoclonal gammopathy of undetermined significance (MGUS). Although MGUS generally demands no treatment, interest in treating premalignant stages to prevent progression to overt malignancies has grown. Better insight in processes underlying progression of MGUS is therefore warranted. Platelet RNA profiles have been shown to reflect information on the topical tumor environment in various cancer types, including multiple myeloma (MM). Our aim was to investigate whether IgM MGUS patients can be distinguished from heal
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Cherng, Hua-Jay J., Xiaojing Yang, Ryan Yancey, et al. "Methylated Whole Genome Cell-Free DNA Sequencing before Chimeric Antigen Receptor T-Cell Therapy for Large B-Cell Lymphoma Predicts Treatment Outcomes." Blood 142, Supplement 1 (2023): 4371. http://dx.doi.org/10.1182/blood-2023-178376.

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Introduction More than half of patients with relapsed or refractory large B-cell lymphoma (R/R LBCL) will experience progressive disease after CD19 chimeric antigen receptor T-cell therapy (CART). Circulating tumor DNA profiling has been used to prognosticate patients before CART, but mainly has focused on identification of somatic genomic aberrations. Epigenetic changes, specifically aberrant DNA methylation, can alter transcriptional regulation of genes important for treatment resistance. Altered methylation features can be detected from cell-free DNA (cfDNA) in patients with LBCL and are as
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Manning, Kyle, Dulaney Miller, Yang Yang, et al. "Abstract LB393: Exosome based multiomics combined with cfDNA methylation reveals complementary signatures in blood based liquid biopsy that carry promise for minimally invasive colorectal cancer screening." Cancer Research 84, no. 7_Supplement (2024): LB393. http://dx.doi.org/10.1158/1538-7445.am2024-lb393.

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Abstract Introduction: Colorectal cancer (CRC) ranks second in cancer morbidity, with approximately 60% of patients being diagnosed at an advanced stage. Here, we apply a multiomic strategy jointly leveraging plasma cell-free DNA (cfDNA) and multiple extracellular vesicle (EV)-derived analytes to enhance CRC diagnostic accuracy. Materials and Methods: Plasma was collected from 96 individuals, 48 CRC patients (stage II-IV) and 48 CRC-negative healthy controls. EVs and cfDNA were isolated from the same plasma sample to look at complementary information within the sample. We developed an EV RNA s
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Eichelser, Corinna, Dieter Flesch-Janys, Jenny Chang-Claude, Klaus Pantel, and Heidi Schwarzenbach. "Deregulated Serum Concentrations of Circulating Cell–Free MicroRNAs miR-17, miR-34a, miR-155, and miR-373 in Human Breast Cancer Development and Progression." Clinical Chemistry 59, no. 10 (2013): 1489–96. http://dx.doi.org/10.1373/clinchem.2013.205161.

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BACKGROUND MicroRNAs (miRs) are small, noncoding RNAs that target genes involved in tumor development and progression. In the current study, we investigated the use of circulating miR concentrations as biomarkers in the serum of breast cancer patients. METHODS We analyzed serum samples from 120 patients with primary breast cancer after surgery and before chemotherapy (M0, classified into 3 subgroups of 40 patients with progesterone/estrogen-positive, HER2-positive, and triple-negative cancer), 32 patients with overt metastasis (M1), and 40 healthy women. Using quantitative TaqMan MicroRNA PCR,
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sprotocols. "Validation of artificial microRNA expression by poly(A) tailing-based RT-PCR." January 15, 2015. https://doi.org/10.5281/zenodo.13971.

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Authors: Rui Shi, Chenmin Yang, Ronald Sederoff & Vincent Chiang ### Abstract Here we describe a protocol for validating expression of artificial microRNAs (amiRNAs) by poly(A) tailing-based RT-PCR. Total RNAs, including amiRNA, are poly(A) tailed using E.coli. poly(A) polymerase. Poly(A) tailed amiRNA can be converted into cDNA along with mRNAs in a reverse transcription reaction primed by a standard poly(T) anchor adaptor. AmiRNA can then be amplified and quantitated by real-time PCR using an amiRNA specific forward primer and a universal adaptor primer. Because the amiRNA forward primer
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Dissertations / Theses on the topic "Reference-Free detected RNAs"

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Torossian, Nouritza. "Study of long non-coding RNAs and reference-free detected RNAs as potential biomarkers and actors of Triple Negative Breast Cancers' chemoresistance." Electronic Thesis or Diss., Université Paris sciences et lettres, 2023. http://www.theses.fr/2023UPSLS057.

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Les cancers du sein triple négatifs (CSTN) sont un sous-type hétérogène représentant 12% à 24% de tous les cancers du sein. Ils ont les plus mauvais pronostics et touchent souvent les femmes jeunes. Le traitement au stade localisé repose essentiellement sur la chimiothérapie, sans thérapie ciblée (hors cas de mutations germinales de BRCA). Quasiment toutes les patientes reçoivent la même chimiothérapie néoadjuvante (CNA) avec anthracyclines et taxanes, ce qui grève leur survie en l’absence de réponse complète pathologique (RCp). L’intensification thérapeutique est la tendance actuelle, notamme
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