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Journal articles on the topic 'Regeneration'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Li, Yan, Lungen Lu, and Xiaobo Cai. "Liver Regeneration and Cell Transplantation for End-Stage Liver Disease." Biomolecules 11, no. 12 (2021): 1907. http://dx.doi.org/10.3390/biom11121907.

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Liver transplantation is the only curative option for end-stage liver disease; however, the limitations of liver transplantation require further research into other alternatives. Considering that liver regeneration is prevalent in liver injury settings, regenerative medicine is suggested as a promising therapeutic strategy for end-stage liver disease. Upon the source of regenerating hepatocytes, liver regeneration could be divided into two categories: hepatocyte-driven liver regeneration (typical regeneration) and liver progenitor cell-driven liver regeneration (alternative regeneration). Due

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Calvin, James M., and Marvin K. Nakayama. "SIMULATION OF PROCESSES WITH MULTIPLE REGENERATION SEQUENCES." Probability in the Engineering and Informational Sciences 14, no. 2 (2000): 179–201. http://dx.doi.org/10.1017/s0269964800142056.

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The classical regenerative method of simulation output analysis exploits the regenerative structure of a stochastic process to break up a path into independent and identically distributed cycles based on a single sequence of regeneration times. If a process is regenerative with respect to more than one sequence of regeneration times, the classical regenerative method does not exploit the additional structure, and the variance of the resulting estimator for certain performance measures (e.g., the time-average variance constant) can vary greatly, depending on the particular regeneration sequence

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Alibardi, Lorenzo. "Regeneration or Scarring Derive from Specific Evolutionary Environmental Adaptations of the Life Cycles in Different Animals." Biology 12, no. 5 (2023): 733. http://dx.doi.org/10.3390/biology12050733.

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The ability to heal or even regenerate large injuries in different animals derives from the evolution of their specific life cycles during geological times. The present, new hypothesis tries to explain the distribution of organ regeneration among animals. Only invertebrates and vertebrates that include larval and intense metamorphic transformations can broadly regenerate as adults. Basically, regeneration competent animals are aquatic while terrestrial species have largely or completely lost most of the regeneration ability. Although genomes of terrestrial species still contain numerous genes

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Paatela, Ellen, Dane Munson, and Nobuaki Kikyo. "Circadian Regulation in Tissue Regeneration." International Journal of Molecular Sciences 20, no. 9 (2019): 2263. http://dx.doi.org/10.3390/ijms20092263.

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Circadian rhythms regulate over 40% of protein-coding genes in at least one organ in the body through mechanisms tied to the central circadian clock and to cell-intrinsic auto-regulatory feedback loops. Distinct diurnal differences in regulation of regeneration have been found in several organs, including skin, intestinal, and hematopoietic systems. Each regenerating system contains a complex network of cell types with different circadian mechanisms contributing to regeneration. In this review, we elucidate circadian regeneration mechanisms in the three representative systems. We also suggest

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Bergamini, Giulia, Mohamad Ahmad, Marina Cocchi, and Davide Malagoli. "A New Protocol of Computer-Assisted Image Analysis Highlights the Presence of Hemocytes in the Regenerating Cephalic Tentacles of Adult Pomacea canaliculata." International Journal of Molecular Sciences 22, no. 9 (2021): 5023. http://dx.doi.org/10.3390/ijms22095023.

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In humans, injuries and diseases can result in irreversible tissue or organ loss. This well-known fact has prompted several basic studies on organisms capable of adult regeneration, such as amphibians, bony fish, and invertebrates. These studies have provided important biological information and helped to develop regenerative medicine therapies, but important gaps concerning the regulation of tissue and organ regeneration remain to be elucidated. To this aim, new models for studying regenerative biology could prove helpful. Here, the description of the cephalic tentacle regeneration in the adu

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Davenport, R. J. "Regenerating Regeneration." Science of Aging Knowledge Environment 2004, no. 35 (2004): ns6. http://dx.doi.org/10.1126/sageke.2004.35.ns6.

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7

Hoban, M., and P. Beresford. "Regenerating regeneration." Community Development Journal 36, no. 4 (2001): 312–20. http://dx.doi.org/10.1093/cdj/36.4.312.

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Batwa, Mohammed, Rand Bakhsh, Zainab Alghamdi, et al. "Regenerative Therapies in the Treatment of Periodontal Defects." JOURNAL OF HEALTHCARE SCIENCES 03, no. 08 (2023): 254–60. http://dx.doi.org/10.52533/johs.2023.30802.

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Regenerative therapies in periodontics have shown great potential in restoring damaged periodontal tissues. Techniques such as guided tissue regeneration (GTR) and guided bone regeneration (GBR) have been effective in promoting the regeneration of periodontal ligament, cementum, and alveolar bone. These approaches create a conducive environment for cell repopulation and exclusion of non-osteogenic cells, leading to successful periodontal tissue regeneration. Tissue engineering approaches, utilizing stem cells, growth factors, and biomaterial scaffolds, have also shown promise in regenerating m

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Maganur, Prabhadevi. "Dental Pulp Stem Cells in Regenerative Therapy." TEXILA INTERNATIONAL JOURNAL OF ACADEMIC RESEARCH 10, no. 2 (2023): 70–77. http://dx.doi.org/10.21522/tijar.2014.10.02.art007.

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Stem cells, also known as progenitor/precursor cells, have the unique trait of self-renewal and multi-lineage differentiation. Dental stem cells (DSCs) are holding a pivotal role during recent times as they thrive as the cornerstone for the development of cell transplantation therapies that correct periodontal disorders and damaged dentin. DSCs are used therapeutically for different organ systems and numerous diseases, including neurological disorders, diabetes, liver disease, bone tissue engineering, and dentistry. In dentistry, the focus is on predominantly regenerating the pulp and damaged

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Gupta, Samudra, Suman Dutta, and Subhra Prakash Hui. "Regenerative Potential of Injured Spinal Cord in the Light of Epigenetic Regulation and Modulation." Cells 12, no. 13 (2023): 1694. http://dx.doi.org/10.3390/cells12131694.

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A spinal cord injury is a form of physical harm imposed on the spinal cord that causes disability and, in many cases, leads to permanent mammalian paralysis, which causes a disastrous global issue. Because of its non-regenerative aspect, restoring the spinal cord’s role remains one of the most daunting tasks. By comparison, the remarkable regenerative ability of some regeneration-competent species, such as some Urodeles (Axolotl), Xenopus, and some teleost fishes, enables maximum functional recovery, even after complete spinal cord transection. During the last two decades of intensive research

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Karra, Ravi, Anne K. Knecht, Kazu Kikuchi та Kenneth D. Poss. "Myocardial NF-κB activation is essential for zebrafish heart regeneration". Proceedings of the National Academy of Sciences 112, № 43 (2015): 13255–60. http://dx.doi.org/10.1073/pnas.1511209112.

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Heart regeneration offers a novel therapeutic strategy for heart failure. Unlike mammals, lower vertebrates such as zebrafish mount a strong regenerative response following cardiac injury. Heart regeneration in zebrafish occurs by cardiomyocyte proliferation and reactivation of a cardiac developmental program, as evidenced by induction of gata4 regulatory sequences in regenerating cardiomyocytes. Although many of the cellular determinants of heart regeneration have been elucidated, how injury triggers a regenerative program through dedifferentiation and epicardial activation is a critical outs

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Fröbisch, Nadia B., Constanze Bickelmann, and Florian Witzmann. "Early evolution of limb regeneration in tetrapods: evidence from a 300-million-year-old amphibian." Proceedings of the Royal Society B: Biological Sciences 281, no. 1794 (2014): 20141550. http://dx.doi.org/10.1098/rspb.2014.1550.

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Salamanders are the only tetrapods capable of fully regenerating their limbs throughout their entire lives. Much data on the underlying molecular mechanisms of limb regeneration have been gathered in recent years allowing for new comparative studies between salamanders and other tetrapods that lack this unique regenerative potential. By contrast, the evolution of animal regeneration just recently shifted back into focus, despite being highly relevant for research designs aiming to unravel the factors allowing for limb regeneration. We show that the 300-million-year-old temnospondyl amphibian M

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King, Ryan S., and Phillip A. Newmark. "The cell biology of regeneration." Journal of Cell Biology 196, no. 5 (2012): 553–62. http://dx.doi.org/10.1083/jcb.201105099.

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Regeneration of complex structures after injury requires dramatic changes in cellular behavior. Regenerating tissues initiate a program that includes diverse processes such as wound healing, cell death, dedifferentiation, and stem (or progenitor) cell proliferation; furthermore, newly regenerated tissues must integrate polarity and positional identity cues with preexisting body structures. Gene knockdown approaches and transgenesis-based lineage and functional analyses have been instrumental in deciphering various aspects of regenerative processes in diverse animal models for studying regenera

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Wang, Wei, Chi-Kuo Hu, An Zeng, et al. "Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates." Science 369, no. 6508 (2020): eaaz3090. http://dx.doi.org/10.1126/science.aaz3090.

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Vertebrates vary in their ability to regenerate, and the genetic mechanisms underlying such disparity remain elusive. Comparative epigenomic profiling and single-cell sequencing of two related teleost fish uncovered species-specific and evolutionarily conserved genomic responses to regeneration. The conserved response revealed several regeneration-responsive enhancers (RREs), including an element upstream to inhibin beta A (inhba), a known effector of vertebrate regeneration. This element activated expression in regenerating transgenic fish, and its genomic deletion perturbed caudal fin regene

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Goulart, Camila Oliveira, Henrique Rocha Mendonça, Julia Teixeira Oliveira, et al. "Repulsive Environment Attenuation during Adult Mouse Optic Nerve Regeneration." Neural Plasticity 2018 (September 12, 2018): 1–11. http://dx.doi.org/10.1155/2018/5851914.

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The regenerative capacity of CNS tracts has ever been a great hurdle to regenerative medicine. Although recent studies have described strategies to stimulate retinal ganglion cells (RGCs) to regenerate axons through the optic nerve, it still remains to be elucidated how these therapies modulate the inhibitory environment of CNS. Thus, the present work investigated the environmental content of the repulsive axon guidance cues, such as Sema3D and its receptors, myelin debris, and astrogliosis, within the regenerating optic nerve of mice submitted to intraocular inflammation + cAMP combined to co

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Prentiss, Nancy K., Mary S. Tyler, and David Dean. "A morphological and histological investigation of the regeneration in Myxicola infundibulum (Montagu, 1808) (Sabellida, Annelida)." Journal of the Marine Biological Association of the United Kingdom 97, no. 5 (2017): 1155–65. http://dx.doi.org/10.1017/s0025315417000248.

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Anterior regeneration of the annelid polychaete, Myxicola infundibulum (Montagu, 1808) is described from histological and SEM perspectives. This article provides additional evidence that anterior and posterior regeneration of isolated worm pieces does occur in this species, but that regenerative ability is restricted to abdominal pieces obtained from small individuals (less than 5 mm in thorax diameter and 10–20 mm in length). New cartilage tissue forms within the regenerating crown, but thoracic regeneration is limited to three segments. Anterior and posterior regeneration occurred within iso

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Banerji, Christopher R. S., Don Henderson, Rabi N. Tawil, and Peter S. Zammit. "Skeletal muscle regeneration in facioscapulohumeral muscular dystrophy is correlated with pathological severity." Human Molecular Genetics 29, no. 16 (2020): 2746–60. http://dx.doi.org/10.1093/hmg/ddaa164.

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Abstract Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant myopathy characterized by slowly progressive skeletal muscle weakness and wasting. While a regenerative response is often provoked in many muscular dystrophies, little is known about whether a regenerative response is regularly elicited in FSHD muscle, prompting this study. For comparison, we also examined the similarly slowly progressing myotonic dystrophy type 2 (DM2). To first investigate regeneration at the transcriptomic level, we used the 200 human gene Hallmark Myogenesis list. This myogenesis biomarker was

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Abidi, Syeda Nayab Fatima, Felicity Ting-Yu Hsu, and Rachel K. Smith-Bolton. "Regenerative growth is constrained by brain tumor to ensure proper patterning in Drosophila." PLOS Genetics 19, no. 12 (2023): e1011103. http://dx.doi.org/10.1371/journal.pgen.1011103.

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Some animals respond to injury by inducing new growth to regenerate the lost structures. This regenerative growth must be carefully controlled and constrained to prevent aberrant growth and to allow correct organization of the regenerating tissue. However, the factors that restrict regenerative growth have not been identified. Using a genetic ablation system in the Drosophila wing imaginal disc, we have identified one mechanism that constrains regenerative growth, impairment of which also leads to erroneous patterning of the final appendage. Regenerating discs with reduced levels of the RNA-re

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Dadgar, Sherry, Zuyi Wang, Helen Johnston, et al. "Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy." Journal of Cell Biology 207, no. 1 (2014): 139–58. http://dx.doi.org/10.1083/jcb.201402079.

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We sought to determine the mechanisms underlying failure of muscle regeneration that is observed in dystrophic muscle through hypothesis generation using muscle profiling data (human dystrophy and murine regeneration). We found that transforming growth factor β–centered networks strongly associated with pathological fibrosis and failed regeneration were also induced during normal regeneration but at distinct time points. We hypothesized that asynchronously regenerating microenvironments are an underlying driver of fibrosis and failed regeneration. We validated this hypothesis using an experime

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Green, Eric M., and Richard T. Lee. "Proteins and Small Molecules for Cellular Regenerative Medicine." Physiological Reviews 93, no. 1 (2013): 311–25. http://dx.doi.org/10.1152/physrev.00005.2012.

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Regenerative medicine seeks to understand tissue development and homeostasis and build on that knowledge to enhance regeneration of injured tissues. By replenishing lost functional tissues and cells, regenerative medicine could change the treatment paradigm for a broad range of degenerative and ischemic diseases. Multipotent cells hold promise as potential building blocks for regenerating lost tissues, but successful tissue regeneration will depend on comprehensive control of multipotent cells–differentiation into a target cell type, delivery to a desired tissue, and integration into a durable

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Gamble, Darian J., Samantha Lopez, Melody Yazdi, Toni Castro-Torres, and Thomas P. Lozito. "Probe Sequencing Analysis of Regenerating Lizard Tails Indicates Crosstalk Among Osteoclasts, Epidermal Cells, and Fibroblasts." Journal of Developmental Biology 13, no. 2 (2025): 15. https://doi.org/10.3390/jdb13020015.

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Lizards are distinguished as the only amniotes, and closest relatives of mammals, capable of multilineage epimorphic regeneration. Tail blastemas of green anole lizards (Anolis carolinensis) consist of col3a1+ fibroblastic connective tissue cells enclosed in krt5+ wound epidermis (WE), both of which are required for regeneration. Blastema and WE formation are known to be closely associated with phagocytic cell populations, including macrophages and osteoclasts. However, it remains unclear what specific phagocytic cell types are required to stimulate regeneration. Here, we explicitly assess the

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Edgar, Allison, Dorothy G. Mitchell, and Mark Q. Martindale. "Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi." Genes 12, no. 6 (2021): 867. http://dx.doi.org/10.3390/genes12060867.

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Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, Mnemiopsis leidyi, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. M. leidyi’s highly mosaic, stereotyped development has been le

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Kami, Katsuya, and Emiko Senba. "In Vivo Activation of STAT3 Signaling in Satellite Cells and Myofibers in Regenerating Rat Skeletal Muscles." Journal of Histochemistry & Cytochemistry 50, no. 12 (2002): 1579–89. http://dx.doi.org/10.1177/002215540205001202.

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Although growth factors and cytokines play critical roles in skeletal muscle regeneration, intracellular signaling molecules that are activated by these factors in regenerating muscles have been not elucidated. Several lines of evidence suggest that leukemia inhibitory factor (LIF) is an important cytokine for the proliferation and survival of myoblasts in vitro and acceleration of skeletal muscle regeneration. To elucidate the role of LIF signaling in regenerative responses of skeletal muscles, we examined the spatial and temporal activation patterns of an LIF-associated signaling molecule, t

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Melo-Narváez, M. Camila, John Stegmayr, Darcy E. Wagner, and Mareike Lehmann. "Lung regeneration: implications of the diseased niche and ageing." European Respiratory Review 29, no. 157 (2020): 200222. http://dx.doi.org/10.1183/16000617.0222-2020.

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Most chronic and acute lung diseases have no cure, leaving lung transplantation as the only option. Recent work has improved our understanding of the endogenous regenerative capacity of the lung and has helped identification of different progenitor cell populations, as well as exploration into inducing endogenous regeneration through pharmaceutical or biological therapies. Additionally, alternative approaches that aim at replacing lung progenitor cells and their progeny through cell therapy, or whole lung tissue through bioengineering approaches, have gained increasing attention. Although impr

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Masood, Nausheen, and Alessio Russo. "Community Perception of Brownfield Regeneration through Urban Rewilding." Sustainability 15, no. 4 (2023): 3842. http://dx.doi.org/10.3390/su15043842.

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Brownfield regeneration using a rewilding approach could provide an opportunity to create new green spaces in our cities. However, studies on public perceptions of rewilding projects are limited. Thus, the purpose of this study was to better understand the public’s perspective of brownfield regeneration and the perceived advantages that these regenerations may give if regenerated as urban green areas as part of rewilding projects. An online survey containing 21 dichotomous and multiple-choice items was created to learn about people’s preferences for brownfield regeneration, the advantages of u

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Guo, Biao, Baojian Wu, Feng Wen, and Kun Qiu. "Cascaded Nonlinear-Optical Loop Mirror-Based All-Optical PAM Regenerator." Applied Sciences 10, no. 1 (2019): 206. http://dx.doi.org/10.3390/app10010206.

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An all-optical regeneration scheme based on cascaded nonlinear-optical loop mirrors (NOLMs) for pulse amplitude modulation (PAM) signals is proposed. The optimal working point (WP) of every NOLM can be set by means of the normalized power transfer function (NPTF) and normalized differential gain (NDG). As examples, the PAM-4 and PAM-8 regenerations based on cascaded two-NOLMs are demonstrated by optimizing the splitting ratios of the optical couplers and the gain coefficient of the inter-stage matching amplifier, achieving the Q-factor improvements of 25.32dB and 21.18dB, respectively. Compare

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Nakajima, Wataru, Soya Nakanishi, Ryosuke Hosoya, Toshiaki Uemoto, Shiro Ohgo, and Naoyuki Wada. "Regenerative Polarity of the Fin Ray in Zebrafish Caudal Fin and Related Tissue Formation on the Cut Surface." Journal of Developmental Biology 9, no. 4 (2021): 50. http://dx.doi.org/10.3390/jdb9040050.

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Zebrafish caudal fin rays are used as a model system for regeneration because of their high regenerative ability, but studies on the regeneration polarity of the fin ray are limited. To investigate this regeneration polarity, we made a hole to excise part of the fin ray and analyzed the regeneration process. We confirmed that the fin rays always regenerated from the proximal margin toward the distal margin, as previously reported; however, regeneration-related genes were expressed at both the proximal and distal edges of the hole in the early stage of regeneration, suggesting that the regenera

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Qin, Yiming, Nanxuan Zhao, Bin Sheng, and Rynson W. H. Lau. "Text2City: One-Stage Text-Driven Urban Layout Regeneration." Proceedings of the AAAI Conference on Artificial Intelligence 38, no. 5 (2024): 4578–86. http://dx.doi.org/10.1609/aaai.v38i5.28257.

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Regenerating urban layout is an essential process for urban regeneration. In this paper, we propose a new task called text-driven urban layout regeneration, which provides an intuitive input modal - text - for users to specify the regeneration, instead of designing complex rules. Given the target region to be regenerated, we propose a one-stage text-driven urban layout regeneration model, Text2City, to jointly and progressively regenerate the urban layout (i.e., road and building layouts) based on textual layout descriptions and surrounding context (i.e., urban layouts and functions of the sur

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Zimowska, Małgorzata, Karolina Archacka, Edyta Brzoska, et al. "IL-4 and SDF-1 Increase Adipose Tissue-Derived Stromal Cell Ability to Improve Rat Skeletal Muscle Regeneration." International Journal of Molecular Sciences 21, no. 9 (2020): 3302. http://dx.doi.org/10.3390/ijms21093302.

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Skeletal muscle regeneration depends on the satellite cells, which, in response to injury, activate, proliferate, and reconstruct damaged tissue. However, under certain conditions, such as large injuries or myopathies, these cells might not sufficiently support repair. Thus, other cell populations, among them adipose tissue-derived stromal cells (ADSCs), are tested as a tool to improve regeneration. Importantly, the pro-regenerative action of such cells could be improved by various factors. In the current study, we tested whether IL-4 and SDF-1 could improve the ability of ADSCs to support the

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Karra, Ravi, Matthew J. Foglia, Wen-Yee Choi, Christine Belliveau, Paige DeBenedittis, and Kenneth D. Poss. "Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish." Proceedings of the National Academy of Sciences 115, no. 35 (2018): 8805–10. http://dx.doi.org/10.1073/pnas.1722594115.

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During heart development and regeneration, coronary vascularization is tightly coupled with cardiac growth. Although inhibiting vascularization causes defects in the innate regenerative response of zebrafish to heart injury, angiogenic signals are not known to be sufficient for triggering regeneration events. Here, by using a transgenic reporter strain, we found that regulatory sequences of the angiogenic factor vegfaa are active in epicardial cells of uninjured animals, as well as in epicardial and endocardial tissue adjacent to regenerating muscle upon injury. Additionally, we find that indu

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Wang, S., X. L. Tan, J. P. Michaud, Z. K. Shi, and F. Zhang. "Sexual selection drives the evolution of limb regeneration in Harmonia axyridis (Coleoptera: Coccinellidae)." Bulletin of Entomological Research 105, no. 2 (2015): 245–52. http://dx.doi.org/10.1017/s0007485315000036.

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AbstractWhen Harmonia axyridis larvae were subjected to amputation of a foreleg in the fourth instar, 83% survived and, of these, 75% regenerated the leg during pupation. Regenerators pupated at heavier weights than controls (unoperated) or non-regenerators, and spent longer in pupation. Regenerated males were preferred by females in choice tests and produced more viable progeny than control males. Unregenerated males were less preferred by females, copulated for shorter periods than control males, and reduced female fecundity. Amputation diminished beneficial paternal effects, whether males r

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Rahman, Fasih Ahmad, Sarah Anne Angus, Kyle Stokes, Phillip Karpowicz, and Matthew Paul Krause. "Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle." International Journal of Molecular Sciences 21, no. 13 (2020): 4575. http://dx.doi.org/10.3390/ijms21134575.

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Regenerative capacity of skeletal muscle declines with age, the cause of which remains largely unknown. We investigated extracellular matrix (ECM) proteins and their regulators during early regeneration timepoints to define a link between aberrant ECM remodeling, and impaired aged muscle regeneration. The regeneration process was compared in young (three month old) and aged (18 month old) C56BL/6J mice at 3, 5, and 7 days following cardiotoxin-induced damage to the tibialis anterior muscle. Immunohistochemical analyses were performed to assess regenerative capacity, ECM remodeling, and the mac

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Grigoryan, Eleonora N. "Study of Natural Longlife Juvenility and Tissue Regeneration in Caudate Amphibians and Potential Application of Resulting Data in Biomedicine." Journal of Developmental Biology 9, no. 1 (2021): 2. http://dx.doi.org/10.3390/jdb9010002.

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The review considers the molecular, cellular, organismal, and ontogenetic properties of Urodela that exhibit the highest regenerative abilities among tetrapods. The genome specifics and the expression of genes associated with cell plasticity are analyzed. The simplification of tissue structure is shown using the examples of the sensory retina and brain in mature Urodela. Cells of these and some other tissues are ready to initiate proliferation and manifest the plasticity of their phenotype as well as the correct integration into the pre-existing or de novo forming tissue structure. Without exc

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Schebesta, Michael, Ching-Ling Lien, Felix B. Engel, and Mark T. Keating. "Transcriptional Profiling of Caudal Fin Regeneration in Zebrafish." Scientific World JOURNAL 6 (2006): 38–54. http://dx.doi.org/10.1100/tsw.2006.326.

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Regeneration of severed limbs in adult animals is restricted to urodele amphibians. Mammals, including humans, have very limited regenerative capabilities and even with proper treatment, only the tips of our digits can grow back. Teleost fish can regenerate amputated fins, the evolutionary ancestors of limbs. To elucidate the principles of limb-fin regeneration, we performed an Affymetrix microarray screen on regenerating caudal fins 12, 24, 48, and 72 h post amputation. Approximately 15,000 zebrafish transcripts were analyzed, identifying 829 transcripts as differentially expressed during reg

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Shimono, M., T. Inoue, and T. Yamamura. "Regeneration of Periodontal Tissues." Advances in Dental Research 2, no. 2 (1988): 223–27. http://dx.doi.org/10.1177/08959374880020020501.

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To elucidate the regenerative capability of the periodontal tissues, we carried out two experiments: (1) Regeneration of the gingival tissue following gingivectomy in rats. Ultrastructurally, regenerating junctional epithelium was similar in morphology to that of untreated animals and appeared to attach to the enamel after five days. Basal lamina and hemidesmosomes were produced faster at the enamel interface than at the connective tissue interface. Gingival tissue was completely regenerated seven days after the gingivectomy. (2) Regeneration of the cementum, periodontal ligament, and alveolar

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Böckelmann, PK, and IJ Bechara. "The regeneration of the tail fin actinotrichia of carp (Cyprinus carpio, Linnaeus, 1758) under the action of naproxen." Brazilian Journal of Biology 69, no. 4 (2009): 1165–72. http://dx.doi.org/10.1590/s1519-69842009000500022.

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A conglomerate of small, rigid, fusiform spicules known as actinotrichia sustains the edge of tail fins of teleost. After amputation, these structures show an extremely fast regenerative capacity. In this study we observed the effect of a nonsteroidal anti-inflammatory drug, naproxen, used in the treatment of degenerative articular diseases, during the process of actinotrichia regeneration. For this purpose, regenerating tissue from animals in contact with the drug was submitted to histochemical and ultrastructural analysis in comparison to tissue from animals under normal conditions, i.e., no

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Zhao, Zelong, Dandan Yin, Kexin Yang, Chunmei Zhang, Linxia Song, and Zhenbiao Xu. "Transcriptome Sequencing Analysis of the Effects of Metformin on the Regeneration of Planarian Dugesia japonica." Genes 16, no. 4 (2025): 365. https://doi.org/10.3390/genes16040365.

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Background: Metformin is a widely used oral hypoglycemic agent for treating type 2 diabetes. Planarians, with their remarkable regenerative abilities, are frequently employed as model organisms in stem cell and regeneration studies. This study aimed to investigate the effects of metformin on planarian regeneration, focusing on the regeneration of eyespots after amputation. Methods: Regenerating planarians with amputated eyespots were exposed to various concentrations of metformin. The regeneration time of the eyespots was measured to assess the effects of metformin. Subsequently, a 1 mmol/L me

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Springhetti, Sina, Vesna Bucan, Christina Liebsch, Andrea Lazaridis, Peter Maria Vogt, and Sarah Strauß. "An Identification and Characterization of the Axolotl (Ambystoma mexicanum, Amex) Telomerase Reverse Transcriptase (Amex TERT)." Genes 13, no. 2 (2022): 373. http://dx.doi.org/10.3390/genes13020373.

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The Mexican axolotl is one of the few vertebrates that is able to replace its lost body parts during lifespan. Due to its remarkable regenerative abilities, the axolotl emerged as a model organism especially for limb regeneration. Telomeres and the telomerase enzyme are crucial for regeneration and protection against aging processes and degenerating diseases. Despite its relevance for regeneration, the axolotl telomerase and telomere length have not yet been investigated. Therefore, in the present paper, we reveal the sequence of the axolotl telomerase reverse transcriptase gene (Tert) and pro

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Milyavsky, Maresha, and Renee Dickie. "Methylene Blue Assay for Estimation of Regenerative Re-Epithelialization In Vivo." Microscopy and Microanalysis 23, no. 1 (2017): 113–21. http://dx.doi.org/10.1017/s1431927617000101.

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AbstractThe rapidity with which epithelial cells cover a wound surface helps determine whether scarring or scar-less healing results. As methylene blue is a vital dye that is absorbed by damaged tissue but not undamaged epidermis, it can be used to assess wound closure. We sought to develop a quantitative methylene blue exclusion assay to estimate the timeframe for re-epithelialization in regenerating appendages in zebrafish and axolotls, two classic model systems of regeneration. Following application of methylene blue to the amputation plane and extensive washing, the regenerating tail was i

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Dolan, Connor P., Lindsay A. Dawson, and Ken Muneoka. "Digit Tip Regeneration: Merging Regeneration Biology with Regenerative Medicine." STEM CELLS Translational Medicine 7, no. 3 (2018): 262–70. http://dx.doi.org/10.1002/sctm.17-0236.

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Alhajlah, Sharif, Adam M. Thompson, and Zubair Ahmed. "Overexpression of Reticulon 3 Enhances CNS Axon Regeneration and Functional Recovery after Traumatic Injury." Cells 10, no. 8 (2021): 2015. http://dx.doi.org/10.3390/cells10082015.

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CNS neurons are generally incapable of regenerating their axons after injury due to several intrinsic and extrinsic factors, including the presence of axon growth inhibitory molecules. One such potent inhibitor of CNS axon regeneration is Reticulon (RTN) 4 or Nogo-A. Here, we focused on RTN3 as its contribution to CNS axon regeneration is currently unknown. We found that RTN3 expression correlated with an axon regenerative phenotype in dorsal root ganglion neurons (DRGN) after injury to the dorsal columns, a well-characterised model of spinal cord injury. Overexpression of RTN3 promoted disinh

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Amrina, Shafi, Zahoor Insha, and A. Mir Mudasir. "Invitro Regeneration of Arabidopsis Thaliana from Suspension and Invitro Cultures and Analysis of Regeneration and Antioxidant Enzyme Levels." International Journal of Trend in Scientific Research and Development 2, no. 1 (2017): 37–45. https://doi.org/10.31142/ijtsrd5843.

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Arabidopsis tissue culture is valuable for any laboratory working on this model plant. Tissue culture methodology facilitates the production of a large number of plants that are genetically identical over a relatively short growth period. Currently this in vitro regeneration system is a good system to study the mechanism by which plants show regenerative plasticity. Plant regeneration is a key technology for successful stable plant transformation, while cell suspension cultures can be exploited for metabolite profiling, kinetic study and mining. In this paper we report methods for the successf

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Cahaya, Cindy, and Sri Lelyati C. Masulili. "Perkembangan Terkini Membran Guided Tissue Regeneration/Guided Bone Regeneration sebagai Terapi Regenerasi Jaringan Periodontal." Majalah Kedokteran Gigi Indonesia 1, no. 1 (2015): 1. http://dx.doi.org/10.22146/majkedgiind.8810.

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Periodontitis adalah salah satu penyakit patologis yang mempengaruhi integritas sistem periodontal yang menyebabkan kerusakan jaringan periodontal yang berlanjut pada kehilangan gigi. Beberapa tahun belakangan ini banyak ketertarikan untuk melakukan usaha regenerasi jaringan periodontal, tidak saja untuk menghentikan proses perjalanan penyakit namun juga mengembalikan jaringan periodontal yang telah hilang. Sasaran dari terapi regeneratif periodontal adalah menggantikan tulang, sementum dan ligamentum periodontal pada permukaan gigi yang terkena penyakit. Prosedur regenerasi antara lain berupa

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Saberian, Elham, Andrej Jenča, Yaser Zafari, et al. "Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review." Cells 13, no. 12 (2024): 1065. http://dx.doi.org/10.3390/cells13121065.

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Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells and targeted 3D scaffolds have been investigated in the search for workable solutions. The use of scaffolds in stem cell-assisted bone regeneration is a crucial component of tissue engineering techniques designed to overcome the drawbacks of traditional bone grafts. This study provides a detailed review of scaffold applications for bone regeneration with stem cells in dentist

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G., Paul Roshan, Seralathan T., Seralathan S., Nishanthini N., and Kayalvizhi B. "The Promise of Regenerative Leadership: Embracing Regeneration for Sustainable Success." International Journal of Research Publication and Reviews 6, no. 1 (2025): 1409–11. https://doi.org/10.55248/gengpi.6.0125.0321.

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Yang, Lin, Jinge Sun, Congyu Yan, et al. "Regeneration of duckweed (Lemna turonifera) involves genetic molecular regulation and cyclohexane release." PLOS ONE 17, no. 1 (2022): e0254265. http://dx.doi.org/10.1371/journal.pone.0254265.

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Plant regeneration is important for vegetative propagation, detoxification and the obtain of transgenic plant. We found that duckweed regeneration could be enhanced by regenerating callus. However, very little is known about the molecular mechanism and the release of volatile organic compounds (VOCs). To gain a global view of genes differently expression profiles in callus and regenerating callus, genetic transcript regulation has been studied. Auxin related genes have been significantly down-regulated in regenerating callus. Cytokinin signal pathway genes have been up-regulated in regeneratin

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Ikeda, Etsuko, Miho Ogawa, Makoto Takeo, and Takashi Tsuji. "Functional ectodermal organ regeneration as the next generation of organ replacement therapy." Open Biology 9, no. 3 (2019): 190010. http://dx.doi.org/10.1098/rsob.190010.

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In this decade, substantial progress in the fields of developmental biology and stem cell biology has ushered in a new era for three-dimensional organ regenerative therapy. The emergence of novel three-dimensional cell manipulation technologies enables the effective mimicking of embryonic organ germ formation using the fate-determined organ-inductive potential of epithelial and mesenchymal stem cells. This advance shows great potential for the regeneration of functional organs with substitution of complete original function in situ . Organoids generated from multipotent stem cells or tissue st

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You, Peng Fei, Yu Xing Peng, Zhen Huang, and Chang Jian Wang. "Tree-Structured Parallel Regeneration Based on Regenerating Codes for Multiple Data Losses in Distributed Storage Systems." Advanced Materials Research 918 (April 2014): 295–300. http://dx.doi.org/10.4028/www.scientific.net/amr.918.295.

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In distributed storage systems, erasure codes represent an attractive data redundancy solution which can provide the same reliability as replication requiring much less storage space. Multiple data losses happens usually and the lost data should be regenerated to maintain data redundancy in distributed storage systems. Regeneration for multiple data losses is expected to be finished as soon as possible, because the regeneration time can influence the data reliability and availability of distributed storage systems. However, multiple data losses is usually regenerated by regenerating single dat

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Sandra, Ferry, Andri Sutanto, Widya Wulandari, et al. "Crucial Triad in Pulp-Dentin Complex Regeneration: Dental Stem Cells, Scaffolds, and Signaling Molecules." Indonesian Biomedical Journal 15, no. 1 (2023): 25–46. http://dx.doi.org/10.18585/inabj.v15i1.2265.

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BACKGROUND: Pulp damage can lead to dentinogenesis impairment, irreversible pulpitis, or pulp necrosis. Despite being the most used endodontic procedure to treat damaged pulp, root canal therapy only results in nonvital teeth which are prone to fractures and secondary infection. Pulp-dentin regeneration has a potential to regenerate structure similar to normal pulp-dentin complex, and can be achieved by combining dental stem cells, scaffold, and signaling molecules. This article reviews the role of various types of dental stem cells, scaffolds, signaling molecules, and their combinations in re

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Di-Iacovo, Nicola, Stefania Pieroni, Danilo Piobbico, et al. "Liver Regeneration and Immunity: A Tale to Tell." International Journal of Molecular Sciences 24, no. 2 (2023): 1176. http://dx.doi.org/10.3390/ijms24021176.

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The physiological importance of the liver is demonstrated by its unique and essential ability to regenerate following extensive injuries affecting its function. By regenerating, the liver reacts to hepatic damage and thus enables homeostasis to be restored. The aim of this review is to add new findings that integrate the regenerative pathway to the current knowledge. An optimal regeneration is achieved through the integration of two main pathways: IL-6/JAK/STAT3, which promotes hepatocyte proliferation, and PI3K/PDK1/Akt, which in turn enhances cell growth. Proliferation and cell growth are ev

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