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Journal articles on the topic 'Regenerative activity'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Gordon, Tal, Tal Zaquin, Mark Alec Kowarsky, et al. "Stemness Activity Underlying Whole Brain Regeneration in a Basal Chordate." Cells 11, no. 23 (2022): 3727. http://dx.doi.org/10.3390/cells11233727.

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Understanding how neurons regenerate following injury remains a central challenge in regenerative medicine. Adult mammals have a very limited ability to regenerate new neurons in the central nervous system (CNS). In contrast, the basal chordate Polycarpa mytiligera can regenerate its entire CNS within seven days of complete removal. Transcriptome sequencing, cellular labeling, and proliferation in vivo essays revealed that CNS regeneration is mediated by a newly formed neural progeny and the activation of neurodevelopmental pathways that are associated with enhanced stem-cell activity. Analyzi

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Fröbisch, Nadia B., Constanze Bickelmann, and Florian Witzmann. "Early evolution of limb regeneration in tetrapods: evidence from a 300-million-year-old amphibian." Proceedings of the Royal Society B: Biological Sciences 281, no. 1794 (2014): 20141550. http://dx.doi.org/10.1098/rspb.2014.1550.

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Salamanders are the only tetrapods capable of fully regenerating their limbs throughout their entire lives. Much data on the underlying molecular mechanisms of limb regeneration have been gathered in recent years allowing for new comparative studies between salamanders and other tetrapods that lack this unique regenerative potential. By contrast, the evolution of animal regeneration just recently shifted back into focus, despite being highly relevant for research designs aiming to unravel the factors allowing for limb regeneration. We show that the 300-million-year-old temnospondyl amphibian M

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Lu, Fangfang, Lyndsay L. Leach, and Jeffrey M. Gross. "mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish." PLOS Genetics 18, no. 3 (2022): e1009628. http://dx.doi.org/10.1371/journal.pgen.1009628.

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The retinal pigment epithelium (RPE) plays numerous critical roles in maintaining vision and this is underscored by the prevalence of degenerative blinding diseases like age-related macular degeneration (AMD), in which visual impairment is caused by progressive loss of RPE cells. In contrast to mammals, zebrafish possess the ability to intrinsically regenerate a functional RPE layer after severe injury. The molecular underpinnings of this regenerative process remain largely unknown yet hold tremendous potential for developing treatment strategies to stimulate endogenous regeneration in the hum

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Mancini, Leonardo, Adriano Fratini, and Enrico Marchetti. "Periodontal Regeneration." Encyclopedia 1, no. 1 (2021): 87–98. http://dx.doi.org/10.3390/encyclopedia1010011.

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Periodontal regeneration is a technique that aims to regenerate the damaged tissue around periodontally compromised teeth. The regenerative process aims to use scaffolds, cells, and growth factors to enhance biological activity.

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Zwi, Stephanie F., Clarisse Choron, Dawei Zheng, et al. "Pharmacological Enhancement of Regeneration-Dependent Regulatory T Cell Recruitment in Zebrafish." International Journal of Molecular Sciences 20, no. 20 (2019): 5189. http://dx.doi.org/10.3390/ijms20205189.

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Regenerative capacity varies greatly between species. Mammals are limited in their ability to regenerate damaged cells, tissues and organs compared to organisms with robust regenerative responses, such as zebrafish. The regeneration of zebrafish tissues including the heart, spinal cord and retina requires foxp3a+ zebrafish regulatory T cells (zTregs). However, it remains unclear whether the muted regenerative responses in mammals are due to impaired recruitment and/or function of homologous mammalian regulatory T cell (Treg) populations. Here, we explore the possibility of enhancing zTreg recr

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Faisal, Muhammad, Afshan Mehreen, Deli Hays, Faiza Yaseen, and Yujun Liang. "The Genetic Odyssey of Axolotl Regeneration: Insights and Innovations." International Journal of Developmental Biology 68, no. 3 (2024): 103–16. https://doi.org/10.1387/ijdb.240111yl.

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The axolotl, a legendary creature with the potential to regenerate complex body parts, is positioned as a powerful model organism due to its extraordinary regenerative capabilities. Axolotl can undergo successful regeneration of multiple structures, providing us with the opportunity to understand the factors that exhibit altered activity between regenerative and non-regenerative animals. This comprehensive review will explore the mysteries of axolotl regeneration, from the initial cellular triggers to the intricate signaling cascades that guide this complex process. We will delve deeply into t

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Paatela, Ellen, Dane Munson, and Nobuaki Kikyo. "Circadian Regulation in Tissue Regeneration." International Journal of Molecular Sciences 20, no. 9 (2019): 2263. http://dx.doi.org/10.3390/ijms20092263.

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Circadian rhythms regulate over 40% of protein-coding genes in at least one organ in the body through mechanisms tied to the central circadian clock and to cell-intrinsic auto-regulatory feedback loops. Distinct diurnal differences in regulation of regeneration have been found in several organs, including skin, intestinal, and hematopoietic systems. Each regenerating system contains a complex network of cell types with different circadian mechanisms contributing to regeneration. In this review, we elucidate circadian regeneration mechanisms in the three representative systems. We also suggest

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Gamble, Darian J., Samantha Lopez, Melody Yazdi, Toni Castro-Torres, and Thomas P. Lozito. "Probe Sequencing Analysis of Regenerating Lizard Tails Indicates Crosstalk Among Osteoclasts, Epidermal Cells, and Fibroblasts." Journal of Developmental Biology 13, no. 2 (2025): 15. https://doi.org/10.3390/jdb13020015.

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Lizards are distinguished as the only amniotes, and closest relatives of mammals, capable of multilineage epimorphic regeneration. Tail blastemas of green anole lizards (Anolis carolinensis) consist of col3a1+ fibroblastic connective tissue cells enclosed in krt5+ wound epidermis (WE), both of which are required for regeneration. Blastema and WE formation are known to be closely associated with phagocytic cell populations, including macrophages and osteoclasts. However, it remains unclear what specific phagocytic cell types are required to stimulate regeneration. Here, we explicitly assess the

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Springhetti, Sina, Vesna Bucan, Christina Liebsch, Andrea Lazaridis, Peter Maria Vogt, and Sarah Strauß. "An Identification and Characterization of the Axolotl (Ambystoma mexicanum, Amex) Telomerase Reverse Transcriptase (Amex TERT)." Genes 13, no. 2 (2022): 373. http://dx.doi.org/10.3390/genes13020373.

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The Mexican axolotl is one of the few vertebrates that is able to replace its lost body parts during lifespan. Due to its remarkable regenerative abilities, the axolotl emerged as a model organism especially for limb regeneration. Telomeres and the telomerase enzyme are crucial for regeneration and protection against aging processes and degenerating diseases. Despite its relevance for regeneration, the axolotl telomerase and telomere length have not yet been investigated. Therefore, in the present paper, we reveal the sequence of the axolotl telomerase reverse transcriptase gene (Tert) and pro

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Castillo, Valentina, Pamela Díaz-Astudillo, Rocío Corrales-Orovio, Sebastián San Martín, and José Tomás Egaña. "Comprehensive Characterization of Tissues Derived from Animals at Different Regenerative Stages: A Comparative Analysis between Fetal and Adult Mouse Skin." Cells 12, no. 9 (2023): 1215. http://dx.doi.org/10.3390/cells12091215.

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Tissue regeneration capabilities vary significantly throughout an organism’s lifespan. For example, mammals can fully regenerate until they reach specific developmental stages, after which they can only repair the tissue without restoring its original architecture and function. The high regenerative potential of fetal stages has been attributed to various factors, such as stem cells, the immune system, specific growth factors, and the presence of extracellular matrix molecules upon damage. To better understand the local differences between regenerative and reparative tissues, we conducted a co

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Perry, Blair W., Audra L. Andrew, Abu Hena Mostafa Kamal, et al. "Multi-species comparisons of snakes identify coordinated signalling networks underlying post-feeding intestinal regeneration." Proceedings of the Royal Society B: Biological Sciences 286, no. 1906 (2019): 20190910. http://dx.doi.org/10.1098/rspb.2019.0910.

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Several snake species that feed infrequently in nature have evolved the ability to massively upregulate intestinal form and function with each meal. While fasting, these snakes downregulate intestinal form and function, and upon feeding restore intestinal structure and function through major increases in cell growth and proliferation, metabolism and upregulation of digestive function. Previous studies have identified changes in gene expression that underlie this regenerative growth of the python intestine, but the unique features that differentiate this extreme regenerative growth from non-reg

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Rahman, Fasih Ahmad, Sarah Anne Angus, Kyle Stokes, Phillip Karpowicz, and Matthew Paul Krause. "Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle." International Journal of Molecular Sciences 21, no. 13 (2020): 4575. http://dx.doi.org/10.3390/ijms21134575.

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Regenerative capacity of skeletal muscle declines with age, the cause of which remains largely unknown. We investigated extracellular matrix (ECM) proteins and their regulators during early regeneration timepoints to define a link between aberrant ECM remodeling, and impaired aged muscle regeneration. The regeneration process was compared in young (three month old) and aged (18 month old) C56BL/6J mice at 3, 5, and 7 days following cardiotoxin-induced damage to the tibialis anterior muscle. Immunohistochemical analyses were performed to assess regenerative capacity, ECM remodeling, and the mac

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Hutson, Thomas H., Claudia Kathe, Ilaria Palmisano, et al. "Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models." Science Translational Medicine 11, no. 487 (2019): eaaw2064. http://dx.doi.org/10.1126/scitranslmed.aaw2064.

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After a spinal cord injury, axons fail to regenerate in the adult mammalian central nervous system, leading to permanent deficits in sensory and motor functions. Increasing neuronal activity after an injury using electrical stimulation or rehabilitation can enhance neuronal plasticity and result in some degree of recovery; however, the underlying mechanisms remain poorly understood. We found that placing mice in an enriched environment before an injury enhanced the activity of proprioceptive dorsal root ganglion neurons, leading to a lasting increase in their regenerative potential. This effec

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Karra, Ravi, Anne K. Knecht, Kazu Kikuchi та Kenneth D. Poss. "Myocardial NF-κB activation is essential for zebrafish heart regeneration". Proceedings of the National Academy of Sciences 112, № 43 (2015): 13255–60. http://dx.doi.org/10.1073/pnas.1511209112.

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Heart regeneration offers a novel therapeutic strategy for heart failure. Unlike mammals, lower vertebrates such as zebrafish mount a strong regenerative response following cardiac injury. Heart regeneration in zebrafish occurs by cardiomyocyte proliferation and reactivation of a cardiac developmental program, as evidenced by induction of gata4 regulatory sequences in regenerating cardiomyocytes. Although many of the cellular determinants of heart regeneration have been elucidated, how injury triggers a regenerative program through dedifferentiation and epicardial activation is a critical outs

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Alshoubaki, Yasmin K., Bhavana Nayer, Surojeet Das, and Mikaël M. Martino. "Modulation of the Activity of Stem and Progenitor Cells by Immune Cells." Stem Cells Translational Medicine 11, no. 3 (2022): 248–58. http://dx.doi.org/10.1093/stcltm/szab022.

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Abstract Numerous components of the immune system, including inflammatory mediators, immune cells and cytokines, have a profound modulatory effect on the homeostatic regulation and regenerative activity of endogenous stem cells and progenitor cells. Thus, understanding how the immune system interacts with stem/progenitor cells could build the foundation to design novel and more effective regenerative therapies. Indeed, utilizing and controlling immune system components may be one of the most effective approaches to promote tissue regeneration. In this review, we first summarize the effects of

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Sazonov, Sergey V. "SOME METHODOLOGICAL TECHNIQUES FOR STUDYING PROLIFERATIVE PROCESSES IN TISSUE CELLS UNDER EXTREME IMPACTS ON THE ORGANISM." Journal of Ural Medical Academic Science 19, no. 5 (2022): 474–84. http://dx.doi.org/10.22138/2500-0918-2022-19-5-474-484.

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When studying regeneration, it is often difficult to give an unambiguous answer to the question of whether the regenerative capacity in mammals decreases or increases under extreme effects on the body, especially when it comes to initially low values of the studied parameters. The assessment of regenerative processes implies the solution of several fundamental questions before conducting research. Ignoring them can lead to methodological miscalculations both in the planning of studies and directly when the results are obtained, and even more so in their subsequent analysis. Materials and metho

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Geng, Fang, Jinmin Ma, Xueyu Li, Zhengyue Hu, and Ruilin Zhang. "Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration." International Journal of Molecular Sciences 22, no. 8 (2021): 3945. http://dx.doi.org/10.3390/ijms22083945.

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Cardiac regenerative capacity varies widely among vertebrates. Zebrafish can robustly regenerate injured hearts and are excellent models to study the mechanisms of heart regeneration. Recent studies have shown that enhancers are able to respond to injury and regulate the regeneration process. However, the mechanisms to activate these regeneration-responsive enhancers (RREs) remain poorly understood. Here, we utilized transient and transgenic analysis combined with a larval zebrafish ventricle ablation model to explore the activation and regulation of a representative RRE. lepb-linked enhancer

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Kishi, Kazuo, Kenichi Katsube, Hiroko Satoh, Nobuaki Imanishi, Hideo Nakajima, and Tatsuo Nakajima. "The Fetal Dermal but Not Loose Fascial Mesenchymal Cells Possess Regenerative Activity of Dermal Structure." Cell Transplantation 14, no. 9 (2005): 709–14. http://dx.doi.org/10.3727/000000005783982729.

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Fetal skin possesses a regenerative activity until certain developmental stages. However, the origin of cells that regenerate dermis after wounding has not been clarified yet. In the present study we located the origin of cells that reconstruct fetal dermal structure by histological examination and by marking cells in the loose fascia. Next we evaluated the regenerative activity of fetal dermal mesenchymal cells by cotransplanting with fetal epidermal cells onto the skin defect of scid mice. We conclude that fetal dermal mesenchymal cells but not loose fascial cells possess regenerative activi

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Musarò, Antonio. "Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities." Cells 9, no. 9 (2020): 2033. http://dx.doi.org/10.3390/cells9092033.

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The capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program and involves the activation of the muscle compartment of stem cells, namely satellite cells, as well as other precursor cells, whose activity is strictly dependent on environmental signals. However, muscle regeneration is severely compromised in several pathological conditions due to either the progressive loss of stem cell populations or to missing signals that limit t

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Prabahar, Archana, Connie S. Chamberlain, Ray Vanderby, et al. "Transcriptomic landscape around wound bed defines regenerative versus non-regenerative outcomes in mouse digit amputation." PLOS Computational Biology 21, no. 4 (2025): e1012997. https://doi.org/10.1371/journal.pcbi.1012997.

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In the mouse distal terminal phalanx (P3), it remains mystery why amputation at less than 33% of the digit results in regeneration, while amputation exceeding 67% leads to non-regeneration. Unraveling the molecular mechanisms underlying this disparity could provide crucial insights for regenerative medicine. In this study, we aim to investigate the tissues within the wound bed to understand the tissue microenvironment associated with regenerative versus non-regenerative outcomes. We employed a P3-specific amputation model in mice, integrated with time-series RNA-seq and a macrophage assay chal

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Shalaeva, Alexandra Y., Roman P. Kostyuchenko, and Vitaly V. Kozin. "Structural and Functional Characterization of the FGF Signaling Pathway in Regeneration of the Polychaete Worm Alitta virens (Annelida, Errantia)." Genes 12, no. 6 (2021): 788. http://dx.doi.org/10.3390/genes12060788.

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Epimorphic regeneration of lost body segments is a widespread phenomenon across annelids. However, the molecular inducers of the cell sources for this reparative morphogenesis have not been identified. In this study, we focused on the role of fibroblast growth factor (FGF) signaling in the posterior regeneration of Alitta virens. For the first time, we showed an early activation of FGF ligands and receptor expression in an annelid regenerating after amputation. The expression patterns indicate that the entire regenerative bud is competent to FGFs, whose activity precedes the initiation of cell

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Diehl, A. M., M. Yin, J. Fleckenstein, et al. "Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury." American Journal of Physiology-Gastrointestinal and Liver Physiology 267, no. 4 (1994): G552—G561. http://dx.doi.org/10.1152/ajpgi.1994.267.4.g552.

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After liver injury, remaining hepatocytes proliferate to regenerate the liver. Although the precise mechanisms that initiate and localize regeneration are unknown, local induction of c-jun is a critical, early step in the response. Treatment of rats with antibodies to tumor necrosis factor-alpha (TNF-alpha), a mediator of liver injury, inhibits regenerative induction of jun nuclear kinase activity and nuclear c-jun expression and alters the DNA binding activity of the c-jun transcription factor, AP-1, in liver. Pretreatment with anti-TNF antibodies does not affect pulmonary or renal c-jun expr

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Shi, De-Li. "RNA-Binding Proteins as Critical Post-Transcriptional Regulators of Cardiac Regeneration." International Journal of Molecular Sciences 24, no. 15 (2023): 12004. http://dx.doi.org/10.3390/ijms241512004.

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Myocardial injury causes death to cardiomyocytes and leads to heart failure. The adult mammalian heart has very limited regenerative capacity. However, the heart from early postnatal mammals and from adult lower vertebrates can fully regenerate after apical resection or myocardial infarction. Thus, it is of particular interest to decipher the mechanism underlying cardiac regeneration that preserves heart structure and function. RNA-binding proteins, as key regulators of post-transcriptional gene expression to coordinate cell differentiation and maintain tissue homeostasis, display dynamic expr

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Rodriguez, Adriana, and Viravuth Yin. "Emerging Roles for Immune Cells and MicroRNAs in Modulating the Response to Cardiac Injury." Journal of Cardiovascular Development and Disease 6, no. 1 (2019): 5. http://dx.doi.org/10.3390/jcdd6010005.

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Stimulating cardiomyocyte regeneration after an acute injury remains the central goal in cardiovascular regenerative biology. While adult mammals respond to cardiac damage with deposition of rigid scar tissue, adult zebrafish and salamander unleash a regenerative program that culminates in new cardiomyocyte formation, resolution of scar tissue, and recovery of heart function. Recent studies have shown that immune cells are key to regulating pro-inflammatory and pro-regenerative signals that shift the injury microenvironment toward regeneration. Defining the genetic regulators that control the

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Julier, Ziad, Rezvan Karami, Bhavana Nayer, et al. "Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling." Science Advances 6, no. 24 (2020): eaba7602. http://dx.doi.org/10.1126/sciadv.aba7602.

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Although growth factors (GFs) are key molecules for regenerative medicine, their use has been limited by issues associated with suboptimal delivery systems and incomplete understanding of their signaling dynamics. Here, we explored how proinflammatory signals affect GF regenerative potential. Using bone regeneration in mouse, we found that the regenerative capacity of two clinically relevant GFs (BMP-2 and PDGF-BB) is impaired by interleukin-1 receptor (IL-1R1). Mechanistically, IL-1R1 activation in bone-forming cells desensitizes them to GFs and accelerates senescence. Moreover, administratio

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Müller, Franziska, Francesco De Virgiliis, Guiping Kong, et al. "CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disability." PLOS Biology 20, no. 9 (2022): e3001310. http://dx.doi.org/10.1371/journal.pbio.3001310.

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The interruption of spinal circuitry following spinal cord injury (SCI) disrupts neural activity and is followed by a failure to mount an effective regenerative response resulting in permanent neurological disability. Functional recovery requires the enhancement of axonal and synaptic plasticity of spared as well as injured fibres, which need to sprout and/or regenerate to form new connections. Here, we have investigated whether the epigenetic stimulation of the regenerative gene expression program can overcome the current inability to promote neurological recovery in chronic SCI with severe d

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Chung, Samuel H., Mehraj R. Awal, James Shay, Melissa M. McLoed, Eric Mazur, and Christopher V. Gabel. "Novel DLK-independent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth." Proceedings of the National Academy of Sciences 113, no. 20 (2016): E2852—E2860. http://dx.doi.org/10.1073/pnas.1600564113.

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During development, a neuron transitions from a state of rapid growth to a stable morphology, and neurons within the adult mammalian CNS lose their ability to effectively regenerate in response to injury. Here, we identify a novel form of neuronal regeneration, which is remarkably independent of DLK-1/DLK, KGB-1/JNK, and other MAPK signaling factors known to mediate regeneration in Caenorhabditis elegans, Drosophila, and mammals. This DLK-independent regeneration in C. elegans has direct genetic and molecular links to a well-studied form of endogenous activity-dependent ectopic axon outgrowth

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Suzuki, Ayako, Shannon McCall, Steve S. Choi, et al. "Interleukin-15 increases hepatic regenerative activity." Journal of Hepatology 45, no. 3 (2006): 410–18. http://dx.doi.org/10.1016/j.jhep.2006.04.008.

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Greisler, Howard P. "Arterial Regenerative Activity After Prosthetic Implantation." Archives of Surgery 120, no. 3 (1985): 315. http://dx.doi.org/10.1001/archsurg.1985.01390270055010.

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Sosnowski, Paweł, Piotr Sass, Paulina Słonimska, et al. "Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice." Pharmaceuticals 15, no. 5 (2022): 610. http://dx.doi.org/10.3390/ph15050610.

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The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna wound closure in BALB/c mice. Our previous research demonstrated that a DNA methyltransferase inhibitor, zebularine, remarkably induced ear pinna regeneration. Altho

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Kopylchuk,, Н. P., I. M. Nykolaichuk,, and М. S. Ursatyi. "Cytochrome P450 enzymes activity in rat liver under conditions of toxic injury and partial hepatectomy." Ukrainian Biochemical Journal 97, no. 2 (2025): 48–58. https://doi.org/10.15407/ubj97.02.048.

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The unique liver ability for reparative regeneration plays a decisive role in restoring its homeostatic potential. However, in certain clinical situations, in particular, due to the damage caused by toxicants of a medicinal origin, the regenerative response may be impaired. Uncontrolled use of nonsteroidal anti-inflammatory drug paracetamol (acetaminophen, APAP) is among the leading causes of acute liver failure. The study focuses on evaluating of p-hydroxylase, N-demethylase, N-oxygenase activity of cytochrome P450 (CYP) enzymes as well as the CYP content in the microsomal fraction of the liv

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Brunauer, Regina, and Ken Muneoka. "The Impact of Aging on Mechanisms of Mammalian Epimorphic Regeneration." Gerontology 64, no. 3 (2018): 300–308. http://dx.doi.org/10.1159/000485320.

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Aging is associated with a significant decline of tissue repair and regeneration, ultimately resulting in tissue dysfunction, multimorbidity, and death. Salamanders possess remarkable regenerative abilities and have been studied with the prospect of inducing regeneration in humans and counteracting regenerative decline with aging. However, epimorphic regeneration, the full replacement of amputated structures, also occurs in mammals. One of the best studied models is digit tip regeneration, which is described for mice, and occurs in humans in a comparable manner. To accomplish regeneration, the

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Moroni, L. "MECHANICALLY INSTRUCTIVE SCAFFOLDS TO STEER TISSUE REGENERATION: MERGING MECHANOBIOLOGY WITH BIOFABRICATION." Orthopaedic Proceedings 106-B, SUPP_2 (2024): 14. http://dx.doi.org/10.1302/1358-992x.2024.2.014.

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Regenerative medicine (RM) promises to restore both the mechanical functionality and the biological composition of tissues after damage. Three-dimensional scaffolds are used in RM to host cells and let them produce proteins that are the building blocks of the native tissues. While regenerating tissues evolve over time through dynamic biomechanical and biochemical changes, current scaffolds’ generation are passive causing mechanical mismatch, suboptimal growth, and pain. Furthermore, current scaffolds ignore the complexity of the reciprocal bio-mechanics regulation, hindering the design of the

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Jackson, Lindsey N., Shawn D. Larson, Scott R. Silva, et al. "PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy." American Journal of Physiology-Gastrointestinal and Liver Physiology 294, no. 6 (2008): G1401—G1410. http://dx.doi.org/10.1152/ajpgi.00062.2008.

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Hepatic resection is associated with rapid proliferation and regeneration of the remnant liver. Phosphatidylinositol 3-kinase (PI3K), composed of a p85α regulatory and a p110α catalytic subunit, participates in multiple cellular processes, including cell growth and survival; however, the role of PI3K in liver regeneration has not been clearly delineated. In this study, we used the potent PI3K inhibitor wortmannin and small interfering RNA (siRNA) targeting the p85α and p110α subunits to determine whether total or selective PI3K inhibition would abrogate the proliferative response of the liver

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Nii, Teruki, and Yoshiki Katayama. "Biomaterial-Assisted Regenerative Medicine." International Journal of Molecular Sciences 22, no. 16 (2021): 8657. http://dx.doi.org/10.3390/ijms22168657.

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This review aims to show case recent regenerative medicine based on biomaterial technologies. Regenerative medicine has arousing substantial interest throughout the world, with “The enhancement of cell activity” one of the essential concepts for the development of regenerative medicine. For example, drug research on drug screening is an important field of regenerative medicine, with the purpose of efficient evaluation of drug effects. It is crucial to enhance cell activity in the body for drug research because the difference in cell condition between in vitro and in vivo leads to a gap in drug

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Torrecillas-Baena, Bárbara, Victoria Pulido-Escribano, Gabriel Dorado, María Ángeles Gálvez-Moreno, Marta Camacho-Cardenosa, and Antonio Casado-Díaz. "Clinical Potential of Mesenchymal Stem Cell-Derived Exosomes in Bone Regeneration." Journal of Clinical Medicine 12, no. 13 (2023): 4385. http://dx.doi.org/10.3390/jcm12134385.

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Bone metabolism is regulated by osteoblasts, osteoclasts, osteocytes, and stem cells. Pathologies such as osteoporosis, osteoarthritis, osteonecrosis, and traumatic fractures require effective treatments that favor bone formation and regeneration. Among these, cell therapy based on mesenchymal stem cells (MSC) has been proposed. MSC are osteoprogenitors, but their regenerative activity depends in part on their paracrine properties. These are mainly mediated by extracellular vesicle (EV) secretion. EV modulates regenerative processes such as inflammation, angiogenesis, cell proliferation, migra

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Lim, Jing Jye, Wan Zurinah Wan Ngah, Vincent Mouly, and Norwahidah Abdul Karim. "Reversal of Myoblast Aging by Tocotrienol Rich Fraction Posttreatment." Oxidative Medicine and Cellular Longevity 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/978101.

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Skeletal muscle satellite cells are heavily involved in the regeneration of skeletal muscle in response to the aging-related deterioration of the skeletal muscle mass, strength, and regenerative capacity, termed as sarcopenia. This study focused on the effect of tocotrienol rich fraction (TRF) on regenerative capacity of myoblasts in stress-induced premature senescence (SIPS). The myoblasts was grouped as young control, SIPS-induced, TRF control, TRF pretreatment, and TRF posttreatment. Optimum dose of TRF, morphological observation, activity of senescence-associatedβ-galactosidase (SA-β-galac

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Abdullaeva, Zh, D. Abdullaev, and R. Kalmatov. "Regenerative Activity of the Skin and Burn Wound Healing in Adults and Children With Second Degree Burns." Bulletin of Science and Practice 10, no. 2 (2024): 266–72. http://dx.doi.org/10.33619/2414-2948/99/27.

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Improving the regenerative activity of the skin is necessary for the timely healing of burn wounds. The regenerative activity of the skin epithelium varies in patients of different ages. To investigate age-related features of the regenerative activity of the skin epithelium and healing of burn wounds in adults and children with second-degree burns and to determine the effectiveness of silver nanoparticles in the healing and treatment of burn wounds. Patients of the Osh Interregional United Clinical Hospital with second-degree burn disease were studied. A literary review of the results of moder

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Knight-Schrijver, Vincent R., Hongorzul Davaapil, Semih Bayraktar, et al. "A single-cell comparison of adult and fetal human epicardium defines the age-associated changes in epicardial activity." Nature Cardiovascular Research 1, no. 12 (2022): 1215–29. http://dx.doi.org/10.1038/s44161-022-00183-w.

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AbstractRe-activating quiescent adult epicardium represents a potential therapeutic approach for human cardiac regeneration. However, the exact molecular differences between inactive adult and active fetal epicardium are not known. In this study, we combined fetal and adult human hearts using single-cell and single-nuclei RNA sequencing and compared epicardial cells from both stages. We found that a migratory fibroblast-like epicardial population only in the fetal heart and fetal epicardium expressed angiogenic gene programs, whereas the adult epicardium was solely mesothelial and immune respo

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Tinduh, Damayanti. "Regenerative Rehabilitation." Indonesian Journal of Physical Medicine & Rehabilitation 7, no. 02 (2019): 1. http://dx.doi.org/10.36803/ijpmr.v7i02.137.

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Rehabilitation is the health strategy which, based on WHO’s integrative model of functioning,disability and health applies and integrates approaches with the goal to enable persons with health conditions experiencing or likely to experience disability to achieve and maintain optimal functioning.The function status associated with physical activity is a health indicator and is the domain of quality of life. Human functioning is a major target of the rehabilitation program.

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Díaz-Díaz, Lymarie M., Natalia Rosario-Meléndez, Andrea Rodríguez-Villafañe, et al. "Antibiotics Modulate Intestinal Regeneration." Biology 10, no. 3 (2021): 236. http://dx.doi.org/10.3390/biology10030236.

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The increased antibiotics usage in biomedical and agricultural settings has been well documented. Antibiotics have now been shown to exert effects outside their purposive use, including effects on physiological and developmental processes. We explored the effect of various antibiotics on intestinal regeneration in the sea cucumber Holothuria glaberrima. For this, holothurians were eviscerated and left to regenerate for 10 days in seawater with different penicillin/streptomycin-based cocktails (100 µg/mL PS) including: 100 µg/mL kanamycin (KPS), 5 µg/mL vancomycin (VPS), and 4 µg/mL (E4PS) or 2

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Dorterler, Ozgul C., Berre Akgun, Mehlika Alper, and Fatma Ayhan. "Improving Antimicrobial Properties of GelMA Biocomposite Hydrogels for Regenerative Endodontic Treatment." Polymers 16, no. 12 (2024): 1675. http://dx.doi.org/10.3390/polym16121675.

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Regenerative endodontics is a developing field involving the restoration of tooth structure and re-vitality of necrotic pulp. One of the most critical clinical considerations for regenerative endodontic procedures is the disinfection of the root canal system, since infection interferes with regeneration, repair, and stem cell activity. In this study, we aimed to provide the synthesis of injectable biopolymeric tissue scaffolds that can be used in routine clinical and regenerative endodontic treatment procedures using Gelatin methacryloyl (GelMA), and to test the antimicrobial efficacy of Gelat

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Chen, William C. W., Zhouguang Wang, Maria Azzurra Missinato, et al. "Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration." Science Advances 2, no. 11 (2016): e1600844. http://dx.doi.org/10.1126/sciadv.1600844.

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Heart attack is a global health problem that leads to significant morbidity, mortality, and health care burden. Adult human hearts have very limited regenerative capability after injury. However, evolutionarily primitive species generally have higher regenerative capacity than mammals. The extracellular matrix (ECM) may contribute to this difference. Mammalian cardiac ECM may not be optimally inductive for cardiac regeneration because of the fibrotic, instead of regenerative, responses in injured adult mammalian hearts. Given the high regenerative capacity of adult zebrafish hearts, we hypothe

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Tomasso, Antonio, Tim Koopmans, Philip Lijnzaad, Kerstin Bartscherer, and Ashley W. Seifert. "An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice ( Acomys )." Science Advances 9, no. 17 (2023). http://dx.doi.org/10.1126/sciadv.adf2331.

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Although most mammals heal injured tissues and organs with scarring, spiny mice ( Acomys ) naturally regenerate skin and complex musculoskeletal tissues. Now, the core signaling pathways driving mammalian tissue regeneration are poorly characterized. Here, we show that, while immediate extracellular signal-regulated kinase (ERK) activation is a shared feature of scarring ( Mus ) and regenerating ( Acomys ) injuries, ERK activity is only sustained at high levels during complex tissue regeneration. Following ERK inhibition, ear punch regeneration in Acomys shifted toward fibrotic repair. Using s

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Karanja, Faith, Subhshri Sahu, Sara Weintraub, et al. "Ecdysone exerts biphasic control of regenerative signaling, coordinating the completion of regeneration with developmental progression." Proceedings of the National Academy of Sciences 119, no. 5 (2022). http://dx.doi.org/10.1073/pnas.2115017119.

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Significance For most organisms, regenerative capacity varies at different stages of development. Changes in regenerative capacity often correlate with significant changes in systemic hormone signaling. Previous studies have independently demonstrated the positive and negative effects of systemic hormone signals on the regenerative activity of tissues. Here, we report that regenerating Drosophila melanogaster tissues produce a biphasic response to ecdysone steroid hormone levels. Below a certain threshold, ecdysone promotes regenerative activity in damaged imaginal discs. As development progre

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Lamanilao, Gene G., Murat Dogan, Prisha S. Patel, et al. "Key Hepatoprotective Roles of Mitochondria in Liver Regeneration." American Journal of Physiology-Gastrointestinal and Liver Physiology, January 17, 2023. http://dx.doi.org/10.1152/ajpgi.00220.2022.

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Treatment of advanced liver disease using surgical modalities is possible due to the liver's innate ability to regenerate following resection. Several key cellular events in the regenerative process converge at the mitochondria, implicating its crucial roles in liver regeneration. Mitochondria enable the regenerating liver to meet immense metabolic demands by coordinating energy production to drive cellular proliferative processes and vital homeostatic functions. Mitochondria are also involved in terminating the regenerative process by mediating apoptosis. Studies have shown that attenuation o

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Rigaud, Vagner O., Robert Hoy, Justin Kurian, Clare Zarka, Michael Behanan, and Mohsin Khan. "Abstract 11254: Lin28a Promotes Persistence of Mononucleated Diploid Cardiomyocytes and Cardiac Regeneration After Injury." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.11254.

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Developmental cardiac tissue holds a remarkable capacity to regenerate after injury and consists of regenerative mononuclear and diploid cardiomyocytes (MNDCMs). Upon maturation, MNDCMs become binucleated or polyploid and exit the cell cycle. Interestingly, CM metabolism undergoes a profound shift that coincides with the cessation of regeneration in the postnatal heart. However, whether reprogramming metabolism promotes persistence of regenerative MNDCMs enhancing cardiac function and regeneration after injury is unknown. Here, we identify a novel role for RNA-binding protein LIN28a, a master

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Mancini, Leonardo, Adriano Fratini, and Enrico Marchetti. "Periodontal Regeneration." January 13, 2021. https://doi.org/10.3390/encyclopedia1010011.

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Periodontal regeneration is a technique that aims to regenerate the damaged tissue around periodontally compromised teeth. The regenerative process aims to use scaffolds, cells, and growth factors to enhance biological activity.

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Quispe-Parra, David J., Joshua G. Medina-Feliciano, Sebastián Cruz-González, Humberto Ortiz-Zuazaga, and José E. García-Arrarás. "Transcriptomic analysis of early stages of intestinal regeneration in Holothuria glaberrima." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-020-79436-2.

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AbstractEchinoderms comprise a group of animals with impressive regenerative capabilities. They can replace complex internal organs following injury or autotomy. In holothurians or sea cucumbers, cellular processes of intestinal regeneration have been extensively studied. The molecular machinery behind this faculty, however, remains to be understood. Here we assembled and annotated a de novo transcriptome using RNA-seq data consisting of regenerating and non-regenerating intestinal tissues from the sea cucumber Holothuria glaberrima. Comparisons of differential expression were made using the m

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Scicchitano, Bianca Maria, Gigliola Sica, and Antonio Musarò. "Stem cells and tissue niche: two faces of the same coin of muscle regeneration." European Journal of Translational Myology 26, no. 4 (2016). http://dx.doi.org/10.4081/ejtm.2016.6125.

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Capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program. However, muscle regeneration is severely compromised in several pathological conditions. It is likely that the restricted tissue repair program under pathological conditions is due to either progressive loss of stem cell populations or to missing signals that limit the damaged tissues to efficiently activate a regenerative program. It is therefore plausible that loss of co

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