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Journal articles on the topic 'Regenerative Medicine Mesenchymal Stem-cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Zheng, Sheng, Guan-Yu Hu, Jun-Hua Li, and Yi-Kai Li. "Potential plausible role of Wharton’s jelly mesenchymal stem cells for diabetic bone regeneration." World Journal of Stem Cells 16, no. 8 (2024): 824–26. http://dx.doi.org/10.4252/wjsc.v16.i8.824.

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This letter addresses the review titled “Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury”. The review highlights the regenerative potential of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) and describes why WJ-MSCs will become one of the most probable stem cells for future regenerative medicine. The potential plausible role of WJ-MSCs for diabetic bone regeneration should be noticeable, which will provide a new strategy for improving bone regeneration under diabetic conditions.

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Greben, A. I., P. S. Eremin, E. Yu Kostromina, P. A. Markov, and I. R. Gilmutdinova. "Mesenchymal stem cells and exosomes in bone defects treatment." Genij Ortopedii 30, no. 1 (2024): 124–33. http://dx.doi.org/10.18019/1028-4427-2024-30-1-124-133.

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Introduction Bone defect management is a critical stage of treatment and rehabilitation that still remains a challenging problem for traumatologists and orthopaedists. The need for tissue engineering techniques is due to limited abilities of the human body to correct bone tissue autoregeneration, especially in comorbid and elderly patients with osteoporosis. Bone autografts is a gold standard in those cases but is associated with certain restrictions. Regenerative medicine and stem cell biology development opened up capabilities to employ new methods for enhancement of bone tissue repair. A sp

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Han, Yu, Xuezhou Li, Yanbo Zhang, Yuping Han, Fei Chang, and Jianxun Ding. "Mesenchymal Stem Cells for Regenerative Medicine." Cells 8, no. 8 (2019): 886. http://dx.doi.org/10.3390/cells8080886.

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In recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and synovium, and differentiate into various cell lineages according to the requirements of specific biomedical applications. As MSCs do not express significant histocompatibility complexes and immune stimulating molecules, they are not detected by immune surveillance and do not lead to graft rejection after transplantation. These properties make them competent biomedical candidates, especially in tissue engineering. We presen

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Sumer, Huseyin, Jun Liu, and Sangho Roh. "Mesenchymal Stem Cells and Regenerative Medicine." Stem Cells International 2018 (October 29, 2018): 1–3. http://dx.doi.org/10.1155/2018/9810972.

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Dokshin, P. M., and A. B. Malashicheva. "Heart stem cells: hope or myth?" Russian Journal of Cardiology 26, no. 10 (2021): 4749. http://dx.doi.org/10.15829/1560-4071-2021-4749.

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The search and study of endogenous heart repair remains an urgent issue in modern regenerative medicine. It is generally accepted that the human heart has a limited regenerative potential, but recent studies show that functionally significant regeneration is possible. However, the mechanisms underlying these processes remain poorly understood. In the heart, there are populations of resident mesenchymal cells that have some properties of stem cells that carry certain markers, such as c-kit+, Sca-1, etc. The ability of these cells to differentiate directly into cardiomyocytes remains controversi

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Caplan, Arnold I. "Adult Mesenchymal Stem Cells: When, Where, and How." Stem Cells International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/628767.

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Adult mesenchymal stem cells (MSCs) have profound medicinal effects at body sites of tissue injury, disease, or inflammation as either endogenously or exogenously supplied. The medicinal effects are either immunomodulatory or trophic or both. When to deliver these mediators of regeneration, where, and by what delivery apparatus or mechanism will directly determine their medical efficacy. The MSCs help manage the innate regenerative capacity of almost every body tissue and the MSCs have only recently been fully appreciated. Perhaps the most skilled physician-manager of the body’s innate regener

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Rehman, Ayesha, Aditya Nigam, Luigi Laino, et al. "Mesenchymal Stem Cells in Soft Tissue Regenerative Medicine: A Comprehensive Review." Medicina 59, no. 8 (2023): 1449. http://dx.doi.org/10.3390/medicina59081449.

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Soft tissue regeneration holds significant promise for addressing various clinical challenges, ranging from craniofacial and oral tissue defects to blood vessels, muscle, and fibrous tissue regeneration. Mesenchymal stem cells (MSCs) have emerged as a promising tool in regenerative medicine due to their unique characteristics and potential to differentiate into multiple cell lineages. This comprehensive review explores the role of MSCs in different aspects of soft tissue regeneration, including their application in craniofacial and oral soft tissue regeneration, nerve regeneration, blood vesse

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Choudhery, Mahmood S., Taqdees Arif, Ruhma Mahmood, et al. "Induced Mesenchymal Stem Cells: An Emerging Source for Regenerative Medicine Applications." Journal of Clinical Medicine 14, no. 6 (2025): 2053. https://doi.org/10.3390/jcm14062053.

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Regenerative medicine is gaining interest in the medical field due to the limitations of conventional treatments, which often fail to address the underlying cause of disease. In recent years, stem cell-based therapies have evolved as a promising alternative approach to treat those diseases that cannot be cured using conventional medicine. Adult stem cells, particularly the mesenchymal stem cells (MSCs), have attracted a lot of attention due to their ability to regenerate and repair human tissues and organs. MSCs isolated from adult tissues are well characterized and are currently the most comm

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Skubis, Aleksandra, Bartosz Sikora, Nikola Zmarzły, Emilia Wojdas, and Urszula Mazurek. "Adipose-derived stem cells: a review of osteogenesis differentiation." Folia Biologica et Oecologica 12 (December 7, 2016): 38–47. http://dx.doi.org/10.1515/fobio-2016-0004.

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This review article provides an overview on adipose-derived stem cells (ADSCs) for implications in bone tissue regeneration. Firstly this article focuses on mesenchymal stem cells (MSCs) which are object of interest in regenerative medicine. Stem cells have unlimited potential for self-renewal and develop into various cell types. They are used for many therapies such as bone tissue regeneration. Adipose tissue is one of the main sources of mesenchymal stem cells (MSCs). Regenerative medicine intends to differentiate ADSC along specific lineage pathways to effect repair of damaged or failing or

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Fortier, Lisa Ann, Laurie Ruth Goodrich, Iris Ribitsch, et al. "One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses." Regenerative Medicine 15, no. 6 (2020): 1775–87. http://dx.doi.org/10.2217/rme-2019-0143.

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Regenerative medicine is commonly used in human and equine athletes. Potential therapies include culture expanded stem cells, stromal vascular fraction of adipose tissue, platelet-rich plasma, bone marrow concentrate, or autologous conditioned serum. The purpose of this manuscript is to disseminate findings from a workshop on the development of translational regenerative medicine in the equine field. Five themes emerged: stem cell characterization and tenogenic differentiation; interactions between mesenchymal stem cells, other cells and the environment; scaffolds and cell packaging; blood- an

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Pérez Fraile, Andrea, Elsa González-Cubero, Susana Martínez-Flórez, Elías R. Olivera, and Vega Villar-Suárez. "Regenerative Medicine Applied to Musculoskeletal Diseases in Equines: A Systematic Review." Veterinary Sciences 10, no. 12 (2023): 666. http://dx.doi.org/10.3390/vetsci10120666.

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Musculoskeletal injuries in horses have a great economic impact, predominantly affecting tendons, ligaments, and cartilage, which have limited natural regeneration. Cell therapy, which uses mesenchymal stem cells due to their tissue differentiation properties and anti-inflammatory and immunoregulatory effects, aims to restore damaged tissue. In this manuscript, we performed a systematic review using the Parsifal tool, searching the PubMed and Web of Science databases for articles on regenerative medicine for equine musculoskeletal injuries. Our review covers 17 experimental clinical studies ca

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Fonticoli, Luigia, Ylenia Della Rocca, Thangavelu Soundara Rajan, et al. "A Narrative Review: Gingival Stem Cells as a Limitless Reservoir for Regenerative Medicine." International Journal of Molecular Sciences 23, no. 8 (2022): 4135. http://dx.doi.org/10.3390/ijms23084135.

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The gingival tissue can be collected in an easy way and represent an accessible source to isolate gingival-derived mesenchymal stem cells (GMSCs). GMSCs are a subpopulation of dental-derived mesenchymal stem cells that show the mesenchymal stem cells (MSCs) features, such as differentiation abilities and immunomodulatory properties. Dental-derived stem cells are also expandable in vitro with genomic stability and the possibility to maintain the stemness properties over a prolonged period of passages. Moreover, several preclinical studies have documented that the extracellular vesicles (EVs) re

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Vashisht, Neha, and Divy Vashisht. "Dental Stem Cells." International Journal of Medical and Dental Sciences 3, no. 1 (2014): 376. http://dx.doi.org/10.19056/ijmdsjssmes/2014/v3i1/80741.

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While the regeneration of a lost tissue is known to mankind for several years, it is only in the recent past that research on regenerative medicine/dentistry has gained momentum and eluded the dramatic yet scientific advancements in the field of molecular biology. The growing understanding of biological concepts in the regeneration of oral/dental tissues coupled with experiments on stem cells is likely to result in a paradigm shift in the therapeutic armamentarium of dental and oral diseases culminating in an intense search for “biological solutions to biological problems.” Stem cells have bee

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Lina, Yani, and Andi Wijaya. "Adipose-Derived Stem Cells for Future Regenerative System Medicine." Indonesian Biomedical Journal 4, no. 2 (2012): 59. http://dx.doi.org/10.18585/inabj.v4i2.164.

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BACKGROUND: The potential use of stem cell-based therapies for repair and regeneration of various tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions for a number of disease. Despite the advances, the availability of stem cells remaining a challenge for both scientist and clinicians in pursuing regenerative medicine. CONTENT: Subcutaneous human adipose tissue is an abundant and accessible cell source for applications in tissue engineering and regenerative medicine. Routinely, the adipose issue is digested with collagenase or related lytic enzymes to re

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Rohban, Rokhsareh, and Thomas Rudolf Pieber. "Mesenchymal Stem and Progenitor Cells in Regeneration: Tissue Specificity and Regenerative Potential." Stem Cells International 2017 (2017): 1–16. http://dx.doi.org/10.1155/2017/5173732.

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It has always been an ambitious goal in medicine to repair or replace morbid tissues for regaining the organ functionality. This challenge has recently gained momentum through considerable progress in understanding the biological concept of the regenerative potential of stem cells. Routine therapeutic procedures are about to shift towards the use of biological and molecular armamentarium. The potential use of embryonic stem cells and invention of induced pluripotent stem cells raised hope for clinical regenerative purposes; however, the use of these interventions for regenerative therapy showe

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Nimiritsky, Peter, Roman Eremichev, Natalya Alexandrushkina, Anastasia Efimenko, Vsevolod Tkachuk, and Pavel Makarevich. "Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration." International Journal of Molecular Sciences 20, no. 4 (2019): 823. http://dx.doi.org/10.3390/ijms20040823.

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Regeneration is a fundamental process attributed to the functions of adult stem cells. In the last decades, delivery of suspended adult stem cells is widely adopted in regenerative medicine as a leading means of cell therapy. However, adult stem cells cannot complete the task of human body regeneration effectively by themselves as far as they need a receptive microenvironment (the niche) to engraft and perform properly. Understanding the mechanisms underlying mammalian regeneration leads us to an assumption that improved outcomes of cell therapy require a specific microenvironment that is gene

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Abbas, Murtadha, S.V. Nadezhdin1, Danil V. Makakov Maklakov, and Ismael Raheem Al-Muhana. "Applications of Mesenchymal Stem Cells in Treatments of Domestic Animals." Kufa Journal For Veterinary Medical Sciences 14, no. 2 (2023): 54–79. http://dx.doi.org/10.36326/kjvs/2023/v14i211728.

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Mesenchymal stem cells: they have received great attention in the field of regenerative medicine due to their ability to differentiate into different cell types and their ability to secrete a wide range of biologically active molecules that repair and regenerate tissues. Stem cells are usually isolated from bone marrow, adipose tissue, or other adult tissues and can be grown in culture media to generate large numbers of cells. Stem cells are widely used in veterinary medicine: for the treatment of bone diseases, diseases of the respiratory and digestive systems, immune diseases. The therapeuti

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Bohiltea, Roxana Elena, Tiberiu Augustin Georgescu, Gina Calinescu, et al. "The elusive role of endometrial progenitor cells in immunoregulation and regenerative medicine: A brief review of current knowledge." Romanian Medical Journal 68, S6 (2021): 7–10. http://dx.doi.org/10.37897/rmj.2021.s6.1.

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The human endometrium is a highly regenerative organ undergoing over 400 cycles of shedding and regeneration over a woman’s lifetime. This massive regenerative capacity is thought to have a stem cell basis, with human endometrial stromal stem cells having already been extensively studied. Endometrial stem cells can be divided into three categories: endometrial epithelial stem/progenitor cells, CD140b+CD146+ or SUSD2+ endometrial mesenchymal stem cells (eMSCs), and side population cells (SPs). Endometrial stem/progenitor cells in the menstruation blood are defined as menstrual stem cells (MenSC

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Costela-Ruiz, Victor J., Lucía Melguizo-Rodríguez, Chiara Bellotti, et al. "Different Sources of Mesenchymal Stem Cells for Tissue Regeneration: A Guide to Identifying the Most Favorable One in Orthopedics and Dentistry Applications." International Journal of Molecular Sciences 23, no. 11 (2022): 6356. http://dx.doi.org/10.3390/ijms23116356.

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The success of regenerative medicine in various clinical applications depends on the appropriate selection of the source of mesenchymal stem cells (MSCs). Indeed, the source conditions, the quality and quantity of MSCs, have an influence on the growth factors, cytokines, extracellular vesicles, and secrete bioactive factors of the regenerative milieu, thus influencing the clinical result. Thus, optimal source selection should harmonize this complex setting and ensure a well-personalized and effective treatment. Mesenchymal stem cells (MSCs) can be obtained from several sources, including bone

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Slaba, Eva. "The biotechnology of using mesenchymal stem cells in regenerative medicine." Acta Tecnología 10, no. 4 (2024): 179–83. https://doi.org/10.22306/atec.v10i4.245.

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Mesenchymal stem cells (MSCs) have garnered significant attention in regenerative medicine due to their multipotent capabilities and ability to differentiate into various cell types, including osteocytes, chondrocytes, and adipocytes. Sourced from bone marrow, adipose tissue, umbilical cord blood, and other tissues, MSCs possess immunomodulatory properties, making them ideal candidates for tissue repair and therapeutic applications. Their capacity to migrate to sites of injury and secrete bioactive molecules that promote tissue regeneration and inhibit inflammation is crucial in treating a ran

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Jakob, Mark, Mario Hambrecht, Jennifer L. Spiegel, et al. "Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Show Comparable Functionality to Their Autologous Origin." Cells 10, no. 1 (2020): 33. http://dx.doi.org/10.3390/cells10010033.

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A multimodal therapeutic approach involving radiotherapy is required when treating head and neck squamous cell carcinoma. However, radiotherapy is restricted due to its high risk for damages to the surrounding healthy tissue of the treated area. Tissue regeneration and wound healing is promoted by the survival and regenerative capacities of tissue-resident or invading stem cells. Mesenchymal stem cells (MSCs) exhibit a promising therapeutic potential in the field of cell-based tissue engineering and regenerative medicine due to their immunomodulatory properties and differentiation capacity. Ho

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Patel, Devang M., Jainy Shah, and Anand S. Srivastava. "Therapeutic Potential of Mesenchymal Stem Cells in Regenerative Medicine." Stem Cells International 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/496218.

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Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal lineages. The intrinsic properties of these cells make them an attractive candidate for clinical applications. MSCs are of keen interest because they can be isolated from a small aspirate of bone marrow or adipose tissues and can be easily expandedin vitro. Moreover, their ability to modulate immune responses makes them an even more attractive candidate for regenerative medicine as allogeneic transplant of these cells is feas

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Maxim, Monica Angela, Olga Soritau, Mihaela Baciut, Simion Bran, and Grigore Baciut. "The role of dental stem cells in regeneration." Medicine and Pharmacy Reports 88, no. 4 (2015): 479–82. http://dx.doi.org/10.15386/cjmed-475.

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Mesenchymal stem cells (MSCs) are adult stem cells that have the capacity of rising multiple cell types.A rich source of mesenchymal stem cells is represented by the dental tissues: the periodontal ligament, the dental pulp, the apical papilla, the dental follicle and the deciduous teeth.The aim of this review is to characterize the main dental- derived mesenchymal stem cell population, and to show their important role in tissue regeneration based on their properties : the multi-potency, the high proliferation rate, the differentiation in multiple cell lineages, the high cell viability and the

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BOHILTEA, Roxana Elena, Erick George NESTIANU, Vlad DIMA, et al. "Stem cells role in regenerative medicine." Romanian Journal of Medical Practice 16, no. 4 (2021): 428–33. http://dx.doi.org/10.37897/rjmp.2021.4.4.

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Stem cells are precursor cells capable of self-renew and of generating numerous mature cell types. As the field of human embryonic stem cells harvesting has been put under questionable ethic issues, other sources are under investigation and present tremendous potential: tissue specific progenitor stem cells, mesenchymal stem cells, umbilical cord cells, bone marrow stem cells, and induced pluripotent stem cells. Stem cells interest different departments of regenerative medicine as well as conservative wildlife. Stem cells might be a viable option for the treatment of pathologies such as spinal

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Shrutika, Bhandare* Priyankab Mohite Vaishnavi Kamble Sanika patil Yogda Rawool Dr. Dharnraj Jadage. "Therapeutic Applications of Umbilical Cord Stem Cells in the Treatment of Human Diseases." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 293–304. https://doi.org/10.5281/zenodo.15332776.

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Umbilical cord stem cells (UCSCs) have garnered significant attention in regenerative medicine due to their unique biological properties, including high proliferative capacity, low immunogenicity, and multipotency. Derived from cord blood and Wharton’s jelly, these cells— primarily mesenchymal and hematopoietic stem cells—have demonstrated therapeutic potential across a wide range of diseases.[1].This review explores the clinical and experimental applications of UCSCs in treating hematological disorders, neurodegenerative diseases, cardiovascular conditions, autoimmune diseas

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Jain, Muskan, Rakesh Kumar Yadav, Promila Verma, Ramesh Bharti, and Vijay Kumar Shakya. "The regenerative revolution in dentistry: stem cells as the future of oral health." International Journal of Research in Medical Sciences 13, no. 7 (2025): 3123–28. https://doi.org/10.18203/2320-6012.ijrms20252059.

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Stem cell-based therapies represent a transformative frontier in regenerative dentistry, offering biologically driven solutions for the restoration of dental and craniofacial tissues. Unlike conventional approaches that rely on synthetic materials, regenerative dentistry utilizes the self-renewing and multipotent nature of stem cells to regenerate pulp, dentin, periodontal ligaments, and even alveolar bone. Various stem cell sources- such as dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), bone marrow mesenchymal

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Park, Dong-Hyuk, David J. Eve, Yong-Gu Chung, and Paul R. Sanberg. "Regenerative Medicine for Neurological Disorders." Scientific World JOURNAL 10 (2010): 470–89. http://dx.doi.org/10.1100/tsw.2010.39.

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The annual meeting of the American Society for Neural Therapy and Repair (ASNTR) has always introduced us to top-notch and up-to-date approaches for regenerative medicine related to neuroscience, ranging from stem cell–based therapy to novel drugs. The 16th ASNTR meeting focused on a variety of different topics, including the unknown pathogenesis or mechanisms of specific neurodegenerative diseases, stem cell biology, and development of novel alternative medicines or devices. Newly developed stem cells, such as amniotic epithelial stem cells and induced pluripotent stem cells, as well as well-

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Lina, Yani, and Andi Wijaya. "Novel Sources of Fetal Stem Cells for Future Regenerative Medicine." Indonesian Biomedical Journal 4, no. 1 (2012): 3. http://dx.doi.org/10.18585/inabj.v4i1.155.

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BACKGROUND: Mesenchymal stromal cells are multipotent cells considered to be of great promise for use in regenerative medicine. However, the cell dose may be a critical factor in many clinical conditions and the yield resulting from the ex vivo expansion of mesenchymal stromal cells derived from bone marrow may be insufficient. Thus, alternative sources of mesenchymal stromal cells need to be explored.CONTENT: There are multiple extra-embryonic tissues emerging during gestation including umbilical cord blood (UCB), amniotic fluid (AF), Wharton’s jelly, the amniotic membrane and the placenta, w

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Tahir, Fatima, and Arsalan Tahir. "Regenerative Medicine and Stem Cell Therapy: Advancements and Future Potential." Wah Academia Journal of Health and Nutrition 1, no. 1 (2025): 18–28. https://doi.org/10.63954/wajhn.1.1.5.3.2025.

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The stem cell therapy and regenerative medicine sectors are quickly expanding due to the profound impact of stem cells on treating situations that were previously considered untreatable. Regenerative medicine, as a sophisticated field related to cellular biology, tissue engineering, and genetics, leverages the potential of stem cells to heal, regenerate, or restore tissues and organs. In this article, we focus on the latest breakthroughs in pluripotent and mesenchymal stem cells, the development of induced pluripotent stem cells (iPSCs), CRISPR gene editing, and their impact on developing prac

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Ikeda, Etsuko, Miho Ogawa, Makoto Takeo, and Takashi Tsuji. "Functional ectodermal organ regeneration as the next generation of organ replacement therapy." Open Biology 9, no. 3 (2019): 190010. http://dx.doi.org/10.1098/rsob.190010.

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In this decade, substantial progress in the fields of developmental biology and stem cell biology has ushered in a new era for three-dimensional organ regenerative therapy. The emergence of novel three-dimensional cell manipulation technologies enables the effective mimicking of embryonic organ germ formation using the fate-determined organ-inductive potential of epithelial and mesenchymal stem cells. This advance shows great potential for the regeneration of functional organs with substitution of complete original function in situ . Organoids generated from multipotent stem cells or tissue st

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Ghoraishizadeh, Saman, Afsoon Ghorishizadeh, Peyman Ghoraishizadeh, Nasibeh Daneshvar, and Mohadese Hashem Boroojerdi. "Application of Nanoscaffolds in Mesenchymal Stem Cell-Based Therapy." Advances in Regenerative Medicine 2014 (September 23, 2014): 1–14. http://dx.doi.org/10.1155/2014/369498.

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Regenerative medicine is an alternative solution for organ transplantation. Stem cells and nanoscaffolds are two essential components in regenerative medicine. Mesenchymal stem cells (MSCs) are considered as primary adult stem cells with high proliferation capacity, wide differentiation potential, and immunosuppression properties which make them unique for regenerative medicine and cell therapy. Scaffolds are engineered nanofibers that provide suitable microenvironment for cell signalling which has a great influence on cell proliferation, differentiation, and biology. Recently, application of

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Zippel, Nina, Margit Schulze, and Edda Tobiasch. "Biomaterials and Mesenchymal Stem Cells for Regenerative Medicine." Recent Patents on Biotechnology 4, no. 1 (2010): 1–22. http://dx.doi.org/10.2174/187220810790069497.

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Kariminekoo, Saber, Aliakbar Movassaghpour, Amirbahman Rahimzadeh, Mehdi Talebi, Karim Shamsasenjan, and Abolfazl Akbarzadeh. "Implications of mesenchymal stem cells in regenerative medicine." Artificial Cells, Nanomedicine, and Biotechnology 44, no. 3 (2016): 749–57. http://dx.doi.org/10.3109/21691401.2015.1129620.

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Wang, Shihua, Xuebin Qu, and Robert Chunhua Zhao. "Mesenchymal stem cells hold promise for regenerative medicine." Frontiers of Medicine 5, no. 4 (2011): 372–78. http://dx.doi.org/10.1007/s11684-011-0164-4.

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Konno, Masamitsu, Atsushi Hamabe, Shinichiro Hasegawa, et al. "Adipose-derived mesenchymal stem cells and regenerative medicine." Development, Growth & Differentiation 55, no. 3 (2013): 309–18. http://dx.doi.org/10.1111/dgd.12049.

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Gholami, Farhad, Ali Ghasemi, Ahmad Reza Bahrami, et al. "The therapeutic effect of autologous bone marrow mesenchymal stem cells to prevent the progress of chronic allograft nephropathy." Journal of Renal Injury Prevention 8, no. 1 (2018): 1–5. http://dx.doi.org/10.15171/jrip.2019.01.

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Progenitor cells or mesenchymal stem cells are new cells, with renovation and regeneration ability and tissues repair. In recent years, administration of stem cells has been introduced to treat a variety of diseases including chronic allograft injury (CAI). It seems that stem cells can create a turning point in regenerative medicine through repair, replacement with damaged tissues or with their paracrine effects.

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Barreca, Maria Magdalena, Patrizia Cancemi, and Fabiana Geraci. "Mesenchymal and Induced Pluripotent Stem Cells-Derived Extracellular Vesicles: The New Frontier for Regenerative Medicine?" Cells 9, no. 5 (2020): 1163. http://dx.doi.org/10.3390/cells9051163.

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Regenerative medicine aims to repair damaged, tissues or organs for the treatment of various diseases, which have been poorly managed with conventional drugs and medical procedures. To date, multimodal regenerative methods include transplant of healthy organs, tissues, or cells, body stimulation to activate a self-healing response in damaged tissues, as well as the combined use of cells and bio-degradable scaffold to obtain functional tissues. Certainly, stem cells are promising tools in regenerative medicine due to their ability to induce de novo tissue formation and/or promote organ repair a

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Narayanan, Raghuvaran, Chun-Chieh Huang, and Sriram Ravindran. "Hijacking the Cellular Mail: Exosome Mediated Differentiation of Mesenchymal Stem Cells." Stem Cells International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3808674.

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Bone transplantation is one of the most widely performed clinical procedures. Consequently, bone regeneration using mesenchymal stem cells and tissue engineering strategies is one of the most widely researched fields in regenerative medicine. Recent scientific consensus indicates that a biomimetic approach is required to achieve proper regeneration of any tissue. Exosomes are nanovesicles secreted by cells that act as messengers that influence cell fate. Although exosomal function has been studied with respect to cancer and immunology, the role of exosomes as inducers of stem cell differentiat

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Debojyoti, Datta. "Exploring regenerative medicine strategies for osteoporosis treatment: Progress, potential, and hurdles." World Journal of Biology Pharmacy and Health Sciences 17, no. 2 (2024): 344–49. https://doi.org/10.5281/zenodo.11296474.

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A major worldwide health problem is osteoporosis, particularly in older people. There are restrictions on current therapies, such as anti-resorptive medications. Promising techniques including stem cell treatment, gene therapy, and growth factors are available in regenerative medicine. Preclinical and clinical research indicate promise for mesenchymal stem cells derived from bone marrow, adipose tissue, and umbilical cord blood. Enhancing bone regeneration with gene therapy that targets osteogenic factors such as BMPs is a promising approach. In order to mend bones, growth factors, cytokines,

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Nandakishore, Ghoshal, Pradhan Arnab, Das Samiran, Bhattacharyya Jayanta, Ghosh Soumitra, and Niyogi Soumadip. "Stem cell-based regenerative prosthodontics: A new era in prosthodontics." Journal of Orofacial Rehabilitation 2, no. 1 (2022): 29–40. https://doi.org/10.5281/zenodo.6437646.

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<strong>Abstract</strong> The ultimate goal for tissue engineering and regenerative medicine is to develop therapies to rejuvenate lost or damaged tissue using engineered or regenerated products derived from either donor or autologous cells. Cell-based therapies are widely used in the field of regenerative medicine. Stem cells are undifferentiated or partially differentiated biological cells found in multicellular organisms that can differentiate into specialized cells. Two types of stem cells are present in humans. These are the embryonic and the adult stem cells. Embryonic stem cells are iso

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Park, You Jeong, Kuniyasu Niizuma, Maxim Mokin, Mari Dezawa, and Cesar V. Borlongan. "Cell-Based Therapy for Stroke." Stroke 51, no. 9 (2020): 2854–62. http://dx.doi.org/10.1161/strokeaha.120.030618.

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Stem cell-based regenerative therapies may rescue the central nervous system following ischemic stroke. Mesenchymal stem cells exhibit promising regenerative capacity in in vitro studies but display little to no incorporation in host tissue after transplantation in in vivo models of stroke. Despite these limitations, clinical trials using mesenchymal stem cells have produced some functional benefits ascribed to their ability to modulate the host’s inflammatory response coupled with their robust safety profile. Regeneration of ischemic brain tissue using stem cells, however, remains elusive in

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Nito, Chikako, Satoshi Suda, Yuko Nitahara-Kasahara, Takashi Okada, and Kazumi Kimura. "Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke." Biomedicines 10, no. 4 (2022): 737. http://dx.doi.org/10.3390/biomedicines10040737.

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Regenerative medicine aims to restore human functions by regenerating organs and tissues using stem cells or living tissues for the treatment of organ and tissue defects or dysfunction. Clinical trials investigating the treatment of cerebral infarction using mesenchymal stem cells, a type of somatic stem cell therapy, are underway. The development and production of regenerative medicines using somatic stem cells is expected to contribute to the treatment of cerebral infarction, a central nervous system disease for which there is no effective treatment. Numerous experimental studies have shown

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Alió del Barrio, Jorge L., Ana De la Mata, María P. De Miguel, et al. "Corneal Regeneration Using Adipose-Derived Mesenchymal Stem Cells." Cells 11, no. 16 (2022): 2549. http://dx.doi.org/10.3390/cells11162549.

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Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important advantage of being easily obtained (in an autologous manner) from low invasive procedures, rendering a high number of multipotent stem cells with the potential to differentiate into several cellular lineages, to show immunomodulatory properties, and to promote tissue regeneration by a paracrine action through the secretion of extracellular vesicles containing trophic factors. This secretome is currently being investigated as a potential source for a cell-free based regenerative therapy for human tissues

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Sulcanese, Ludovica, Giuseppe Prencipe, Angelo Canciello, et al. "Stem-Cell-Driven Chondrogenesis: Perspectives on Amnion-Derived Cells." Cells 13, no. 9 (2024): 744. http://dx.doi.org/10.3390/cells13090744.

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Regenerative medicine harnesses stem cells’ capacity to restore damaged tissues and organs. In vitro methods employing specific bioactive molecules, such as growth factors, bio-inductive scaffolds, 3D cultures, co-cultures, and mechanical stimuli, steer stem cells toward the desired differentiation pathways, mimicking their natural development. Chondrogenesis presents a challenge for regenerative medicine. This intricate process involves precise modulation of chondro-related transcription factors and pathways, critical for generating cartilage. Cartilage damage disrupts this process, impeding

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Sui, B., C. Chen, X. Kou, et al. "Pulp Stem Cell–Mediated Functional Pulp Regeneration." Journal of Dental Research 98, no. 1 (2018): 27–35. http://dx.doi.org/10.1177/0022034518808754.

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The preservation of vital dental pulp with vasculature and nerve components remains one of the most significant challenges in modern dentistry. Due to the immense potential for neurovascularization, mesenchymal stem cell (MSC) transplantation has shown emerging promise in regenerative medicine and dental translational practice. Actually, pulp mesenchymal stem cells, including postnatal dental pulp stem cells (from permanent teeth) and stem cells from human exfoliated deciduous teeth, possess unique properties based on their origins from neural crest or glial cells. Furthermore, they reside in

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Gallicchio, Vincent S., and Kennedy Jordahl. "Application of mesenchymal stem cells for the treatment of traumatic brain injury and neurodegenerative diseases." Journal of Stem Cell Research & Therapeutics 7, no. 1 (2021): 1–10. http://dx.doi.org/10.15406/jsrt.2021.07.00149.

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Despite the prevalence of traumatic brain injuries (TBIs) and neurodegenerative diseases, there is still a lack of effective and efficient therapeutic treatment options. TBI triggers an innate immune response and releases inflammatory molecules, creating a hostile environment that inhibits repair and regeneration. TBI has also been linked to a higher risk of suffering from neurodegenerative diseases, such as Parkinson’s, Alzheimer’s and Huntington’s disease in later years. Novel stem cell research has provided a treatment option that overcomes existing barriers and can be used in regenerative

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Torrecillas-Baena, Bárbara, Victoria Pulido-Escribano, Gabriel Dorado, María Ángeles Gálvez-Moreno, Marta Camacho-Cardenosa, and Antonio Casado-Díaz. "Clinical Potential of Mesenchymal Stem Cell-Derived Exosomes in Bone Regeneration." Journal of Clinical Medicine 12, no. 13 (2023): 4385. http://dx.doi.org/10.3390/jcm12134385.

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Bone metabolism is regulated by osteoblasts, osteoclasts, osteocytes, and stem cells. Pathologies such as osteoporosis, osteoarthritis, osteonecrosis, and traumatic fractures require effective treatments that favor bone formation and regeneration. Among these, cell therapy based on mesenchymal stem cells (MSC) has been proposed. MSC are osteoprogenitors, but their regenerative activity depends in part on their paracrine properties. These are mainly mediated by extracellular vesicle (EV) secretion. EV modulates regenerative processes such as inflammation, angiogenesis, cell proliferation, migra

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Bina, Valentina, Alice Maria Brancato, Laura Caliogna, et al. "Mesenchymal Stem Cells and Secretome as a New Possible Approach to Treat Cartilage Damage: An In Vitro Study." Biomolecules 14, no. 9 (2024): 1068. http://dx.doi.org/10.3390/biom14091068.

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Introduction: Osteoarthritis is a degenerative condition of the cartilage, often common among the population and occurs frequently with aging. Many factors are decisive for the development of its pathogenesis such as age, obesity, trauma, mechanical load, and modification of synovial biology. The main features of osteoarthritis are chondrocytes and cartilage matrix loss, which lead to pain, loss of function of the whole joint, and disability, representing a relevant health problem. Recently, a new therapeutic approach based on cell therapy has been studying the regenerative ability of mesenchy

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Gallicchio, Vincent, and Sarah Tanner. "Mesenchymal stem cells as potential regenerative treatment for pre-eclampsia: a review." Journal of Stem Cell Research & Therapeutics 6, no. 1 (2020): 56–62. http://dx.doi.org/10.15406/jsrt.2020.06.00141.

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Research in regenerative medicine and tissue engineering has continued to show advancement towards being a potential cure for autoimmune disorders. Specifically, mesenchymal stem cells show great potential in tissue regeneration and repair. Pre-eclampsia is a systematic endothelial dysfunction disorder that leads to hypertension and proteinuria. This occurs when syncytiotrophoblast are under stress and can’t properly remodel the spiral arteries of the placental bed. Mesenchymal stem cells are being used to reverse the damage already done by pre-eclampsia and restore equilibrium. Current resear

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Abe, Takaharu, Keisuke Sumi, Ryo Kunimatsu, et al. "Bone Regeneration in a Canine Model of Artificial Jaw Cleft Using Bone Marrow–Derived Mesenchymal Stem Cells and Carbonate Hydroxyapatite Carrier." Cleft Palate-Craniofacial Journal 57, no. 2 (2019): 208–17. http://dx.doi.org/10.1177/1055665619868868.

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Objective: Cleft lip and palate (CLP) is a common anomaly of the orofacial region. Mesenchymal stem cell (MSC) transplantation has been a focus of regenerative medicine, and its application to the repair of bone defects in patients with CLP is highly anticipated. This study investigated the potential for using MSCs to regenerate bone in a jaw cleft as well as the survival of transplanted MSCs using a canine model of CLP. Design: Mesenchymal stem cells collected from the bone marrow of beagle dogs were transplanted along with carbonate hydroxyapatite into jaw clefts in beagle dogs. Mesenchymal

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