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Journal articles on the topic 'REGIONS OF ORIGIN'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Ciardo, Diletta, Olivier Haccard, Hemalatha Narassimprakash, et al. "Organization of DNA Replication Origin Firing in Xenopus Egg Extracts: The Role of Intra-S Checkpoint." Genes 12, no. 8 (2021): 1224. http://dx.doi.org/10.3390/genes12081224.

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During cell division, the duplication of the genome starts at multiple positions called replication origins. Origin firing requires the interaction of rate-limiting factors with potential origins during the S(ynthesis)-phase of the cell cycle. Origins fire as synchronous clusters which is proposed to be regulated by the intra-S checkpoint. By modelling the unchallenged, the checkpoint-inhibited and the checkpoint protein Chk1 over-expressed replication pattern of single DNA molecules from Xenopus sperm chromatin replicated in egg extracts, we demonstrate that the quantitative modelling of data

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2

Guan, Zeqiang, Christina M. Hughes, Settapong Kosiyatrakul, et al. "Decreased replication origin activity in temporal transition regions." Journal of Cell Biology 187, no. 5 (2009): 623–35. http://dx.doi.org/10.1083/jcb.200905144.

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In the mammalian genome, early- and late-replicating domains are often separated by temporal transition regions (TTRs) with novel properties and unknown functions. We identified a TTR in the mouse immunoglobulin heavy chain (Igh) locus, which contains replication origins that are silent in embryonic stem cells but activated during B cell development. To investigate which factors contribute to origin activation during B cell development, we systematically modified the genetic and epigenetic status of the endogenous Igh TTR and used a single-molecule approach to analyze DNA replication. Introduc

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Lucas, P. W., J. H. Hough, A. C. Chrysostomou, and J. A. Bailey. "Circular Polarisation in Star Forming Regions: The Origin of Homochirality?" Symposium - International Astronomical Union 213 (2004): 145–48. http://dx.doi.org/10.1017/s0074180900193155.

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The origin of homochirality is one of the longest-standing puzzles in understanding the origins of life. In the laboratory, illumination by circularly polarised UV radiation (asymmetric photolysis) is an effective means of producing an enantiomeric excess in an otherwise racemic mix of chiral molecules. In the natural world, however, it has proven difficult to identify a suitable source of Circularly Polarised Light (CPL). Recent observations of L-excesses of 2–9% for a number of α-methyl amino acids in the Murchison meteorite and our discovery of large degrees of CPL in some star forming regi

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Inskip, K. J., M. Villar-Martín, C. Tadhunter, J. Holt, and R. Morganti. "The origin of extended emission line regions." New Astronomy Reviews 51, no. 1-2 (2007): 47–51. http://dx.doi.org/10.1016/j.newar.2006.10.004.

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5

Bresler, Leo, Troy Shinbrot, Guy Metcalfe, and Julio M. Ottino. "Isolated mixing regions: origin, robustness and control." Chemical Engineering Science 52, no. 10 (1997): 1623–36. http://dx.doi.org/10.1016/s0009-2509(96)00406-x.

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6

Graumann, Peter L., and Richard Losick. "Coupling of Asymmetric Division to Polar Placement of Replication Origin Regions in Bacillus subtilis." Journal of Bacteriology 183, no. 13 (2001): 4052–60. http://dx.doi.org/10.1128/jb.183.13.4052-4060.2001.

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ABSTRACT Entry into sporulation in Bacillus subtilis is characterized by the formation of a polar septum, which asymmetrically divides the developing cell into forespore (the smaller cell) and mother cell compartments, and by migration of replication origin regions to extreme opposite poles of the cell. Here we show that polar septation is closely correlated with movement of replication origins to the extreme poles of the cell. Replication origin regions were visualized by the use of a cassette of tandem copies oflacO that had been inserted in the chromosome near the origin of replication and

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7

Hoggard, Timothy, Carolin A. Müller, Conrad A. Nieduszynski, Michael Weinreich, and Catherine A. Fox. "Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin." Proceedings of the National Academy of Sciences 117, no. 25 (2020): 14314–21. http://dx.doi.org/10.1073/pnas.2004664117.

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A eukaryotic chromosome relies on the function of multiple spatially distributed DNA replication origins for its stable inheritance. The spatial location of an origin is determined by the chromosomal position of an MCM complex, the inactive form of the DNA replicative helicase that is assembled onto DNA in G1-phase (also known as origin licensing). While the biochemistry of origin licensing is understood, the mechanisms that promote an adequate spatial distribution of MCM complexes across chromosomes are not. We have elucidated a role for the Sir2 histone deacetylase in establishing the normal

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8

Kim, Soo-Mi, and Joel A. Huberman. "Multiple Orientation-Dependent, Synergistically Interacting, Similar Domains in the Ribosomal DNA Replication Origin of the Fission Yeast, Schizosaccharomyces pombe." Molecular and Cellular Biology 18, no. 12 (1998): 7294–303. http://dx.doi.org/10.1128/mcb.18.12.7294.

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ABSTRACT Previous investigations have shown that the fission yeast,Schizosaccharomyces pombe, has DNA replication origins (500 to 1500 bp) that are larger than those in the budding yeast,Saccharomyces cerevisiae (100 to 150 bp). Deletion and linker substitution analyses of two fission yeast origins revealed that they contain multiple important regions with AT-rich asymmetric (abundant A residues in one strand and T residues in the complementary strand) sequence motifs. In this work we present the characterization of a third fission yeast replication origin, ars3001, which is relatively small (

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9

MAEDA, Yoshimi. "Differential scanning calorimetry of DNA replication origin regions." Seibutsu Butsuri 29, no. 5 (1989): 243–47. http://dx.doi.org/10.2142/biophys.29.5_243.

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10

Choudhuri, Arnab Rai, Piyali Chatterjee, and Dibyendu Nandy. "The Origin of Helicity in Solar Active Regions." Proceedings of the International Astronomical Union 2004, IAUS223 (2004): 45–48. http://dx.doi.org/10.1017/s1743921304005083.

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11

Mara, Andrea, Matteo Migliorini, Marco Ciulu, et al. "Elemental Fingerprinting Combined with Machine Learning Techniques as a Powerful Tool for Geographical Discrimination of Honeys from Nearby Regions." Foods 13, no. 2 (2024): 243. http://dx.doi.org/10.3390/foods13020243.

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Discrimination of honey based on geographical origin is a common fraudulent practice and is one of the most investigated topics in honey authentication. This research aims to discriminate honeys according to their geographical origin by combining elemental fingerprinting with machine-learning techniques. In particular, the main objective of this study is to distinguish the origin of unifloral and multifloral honeys produced in neighboring regions, such as Sardinia (Italy) and Spain. The elemental compositions of 247 honeys were determined using Inductively Coupled Plasma Mass Spectrometry (ICP

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12

Vildana, Alibabić, Oraščanin Melisa, and Vahčić Nada. "Geographical origin of honey from eight sub-regions of Bosnia and Herzegovina." Czech Journal of Food Sciences 35, No. 6 (2017): 488–95. http://dx.doi.org/10.17221/82/2017-cjfs.

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Principal component analysis (PCA) and cluster analysis (CA) were used to define the geographical origin of three types of monofloral (chestnut, linden, and acacia), two types of multifloral (meadow and mixed), and forest honey produced over two consecutive harvest seasons in the Una-Sana Canton (Bosnia and Herzegovina), which is geographically divided into eight sub-regions. Statistical analysis was applied to the measurement of physico-chemical and sensory parameters, as well as micro- and macronutrient (K, Na, Mg, Zn, Fe, Mn, and Al) content, along with some heavy metals (Cd, Pb, and As). U

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13

Belkheir, DEHANE. "Study of the variability of cork growth in northern Algeria." Agriculture and Forestry Journal 1, no. 1 (2017): 33–41. https://doi.org/10.5281/zenodo.810070.

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The study of the growth of Algerian cork according to the concept of origin was carried out on 100 samples of 20x20cm representing ten production regions (El Tarf, Jijel, Skikda, Mila, Guelma, Bejaia, TiziOuzou, M'Sila, Hafir, Zarieffet). The caliber varies significantly from one to another (Origin 1). On average, it was about 29.75 mm with a still regressive aspect in the Western Region (Origin 2) and the Mountain Zone (Origin 3). The mean annual increments for an 8 year production cycle follow the same path, very significantly different between the samples of the Eastern Region (3,14mm year<

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Graumann, Peter L. "Bacillus subtilis SMC Is Required for Proper Arrangement of the Chromosome and for Efficient Segregation of Replication Termini but Not for Bipolar Movement of Newly Duplicated Origin Regions." Journal of Bacteriology 182, no. 22 (2000): 6463–71. http://dx.doi.org/10.1128/jb.182.22.6463-6471.2000.

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ABSTRACT SMC protein is required for chromosome condensation and for the faithful segregation of daughter chromosomes in Bacillus subtilis. The visualization of specific sites on the chromosome showed that newly duplicated origin regions in growing cells of ansmc mutant were able to segregate from each other but that the location of origin regions was frequently aberrant. In contrast, the segregation of replication termini was impaired in smcmutant cells. This analysis was extended to germinating spores of ansmc mutant. The results showed that during germination, newly duplicated origins, but

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15

Stanojcic, Slavica, Jean-Marc Lemaitre, Konstantin Brodolin, Etienne Danis, and Marcel Mechali. "In Xenopus Egg Extracts, DNA Replication Initiates Preferentially at or near Asymmetric AT Sequences." Molecular and Cellular Biology 28, no. 17 (2008): 5265–74. http://dx.doi.org/10.1128/mcb.00181-08.

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ABSTRACT Previous observations led to the conclusion that in Xenopus eggs and during early development, DNA replication initiates at regular intervals but with no apparent sequence specificity. Conversely, here, we present evidence for site-specific DNA replication origins in Xenopus egg extracts. Using λ DNA, we show that DNA replication origins are activated in clusters in regions that contain closely spaced adenine or thymine asymmetric tracks used as preferential initiation sites. In agreement with these data, AT-rich asymmetric sequences added as competitors preferentially recruit origin

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16

Miotto, Benoit, Zhe Ji, and Kevin Struhl. "Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers." Proceedings of the National Academy of Sciences 113, no. 33 (2016): E4810—E4819. http://dx.doi.org/10.1073/pnas.1609060113.

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The origin recognition complex (ORC) binds sites from which DNA replication is initiated. We address ORC binding selectivity in vivo by mapping ∼52,000 ORC2 binding sites throughout the human genome. The ORC binding profile is broader than those of sequence-specific transcription factors, suggesting that ORC is not bound or recruited to specific DNA sequences. Instead, ORC binds nonspecifically to open (DNase I-hypersensitive) regions containing active chromatin marks such as H3 acetylation and H3K4 methylation. ORC sites in early and late replicating regions have similar properties, but there

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17

Fu, Hai, and Alan Stockton. "A Common Origin for Quasar Extended Emission-Line Regions and Their Broad-Line Regions." Astrophysical Journal 664, no. 2 (2007): L75—L78. http://dx.doi.org/10.1086/520959.

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18

Lee, Philina S., Daniel Chi-Hong Lin, Shigeki Moriya, and Alan D. Grossman. "Effects of the Chromosome Partitioning Protein Spo0J (ParB) on oriC Positioning and Replication Initiation in Bacillus subtilis." Journal of Bacteriology 185, no. 4 (2003): 1326–37. http://dx.doi.org/10.1128/jb.185.4.1326-1337.2003.

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ABSTRACT Spo0J (ParB) of Bacillus subtilis is a DNA-binding protein that belongs to a conserved family of proteins required for efficient plasmid and chromosome partitioning in many bacterial species. We found that Spo0J contributes to the positioning of the chromosomal oriC region, but probably not by recruiting the origin regions to specific subcellular locations. In wild-type cells during exponential growth, duplicated origin regions were generally positioned around the cell quarters. In a spo0J null mutant, sister origin regions were often closer together, nearer to midcell. We found, by u

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19

Hudman, Lloyd E., and James A. Davis. "Changes and patterns of origin regions of international tourism." GeoJournal 34, no. 4 (1994): 481–90. http://dx.doi.org/10.1007/bf00813144.

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20

Pajkos, Mátyás, András Zeke, and Zsuzsanna Dosztányi. "Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions." Biomolecules 10, no. 8 (2020): 1115. http://dx.doi.org/10.3390/biom10081115.

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Cancer is a heterogeneous genetic disease that alters the proper functioning of proteins involved in key regulatory processes such as cell cycle, DNA repair, survival, or apoptosis. Mutations often accumulate in hot-spots regions, highlighting critical functional modules within these proteins that need to be altered, amplified, or abolished for tumor formation. Recent evidence suggests that these mutational hotspots can correspond not only to globular domains, but also to intrinsically disordered regions (IDRs), which play a significant role in a subset of cancer types. IDRs have distinct func

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21

Bai, Yongsheng, Claudio Casola, and Esther Betrán. "Evolutionary origin of regulatory regions of retrogenes in Drosophila." BMC Genomics 9, no. 1 (2008): 241. http://dx.doi.org/10.1186/1471-2164-9-241.

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22

Fan, Y., G. H. Fisher, and E. E. Deluca. "The origin of morphological asymmetries in bipolar active regions." Astrophysical Journal 405 (March 1993): 390. http://dx.doi.org/10.1086/172370.

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23

King, Geoffrey, and Michael Ellis. "The origin of large local uplift in extensional regions." Nature 348, no. 6303 (1990): 689–93. http://dx.doi.org/10.1038/348689a0.

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24

Piškur, Jure. "Origin of the duplicated regions in the yeast genomes." Trends in Genetics 17, no. 6 (2001): 302–3. http://dx.doi.org/10.1016/s0168-9525(01)02308-3.

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25

Aoki, Kazuteru, Miki Shinohara, and Tateo Itoh. "Distinct Functions of the Two Specificity Determinants in Replication Initiation of Plasmids ColE2-P9 and ColE3-CA38." Journal of Bacteriology 189, no. 6 (2007): 2392–400. http://dx.doi.org/10.1128/jb.01695-06.

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ABSTRACT The plasmid ColE2-P9 Rep protein specifically binds to the cognate replication origin to initiate DNA replication. The replicons of the plasmids ColE2-P9 and ColE3-CA38 are closely related, although the actions of the Rep proteins on the origins are specific to the plasmids. The previous chimera analysis identified two regions, regions A and B, in the Rep proteins and two sites, α and β, in the origins as specificity determinants and showed that when each component of the region A-site α pair and the region B-site β pair is derived from the same plasmid, plasmid DNA replication is eff

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Ge, Xin Quan, and J. Julian Blow. "Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories." Journal of Cell Biology 191, no. 7 (2010): 1285–97. http://dx.doi.org/10.1083/jcb.201007074.

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Replication origins are licensed by loading MCM2-7 hexamers before entry into S phase. However, only ∼10% of licensed origins are normally used in S phase, with the others remaining dormant. When fork progression is inhibited, dormant origins initiate nearby to ensure that all of the DNA is eventually replicated. In apparent contrast, replicative stress activates ataxia telangiectasia and rad-3–related (ATR) and Chk1 checkpoint kinases that inhibit origin firing. In this study, we show that at low levels of replication stress, ATR/Chk1 predominantly suppresses origin initiation by inhibiting t

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Ciardo, Diletta, Arach Goldar, and Kathrin Marheineke. "On the Interplay of the DNA Replication Program and the Intra-S Phase Checkpoint Pathway." Genes 10, no. 2 (2019): 94. http://dx.doi.org/10.3390/genes10020094.

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DNA replication in eukaryotes is achieved by the activation of multiple replication origins which needs to be precisely coordinated in space and time. This spatio-temporal replication program is regulated by many factors to maintain genome stability, which is frequently threatened through stresses of exogenous or endogenous origin. Intra-S phase checkpoints monitor the integrity of DNA synthesis and are activated when replication forks are stalled. Their activation leads to the stabilization of forks, to the delay of the replication program by the inhibition of late firing origins, and the del

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Akiyama, Rikuto, Kana Suzuki, Yvan Llave, and Takashi Matsumoto. "Fluorescence Spectroscopy and a Convolutional Neural Network for High-Accuracy Japanese Green Tea Origin Identification." AgriEngineering 7, no. 4 (2025): 95. https://doi.org/10.3390/agriengineering7040095.

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This study aims to develop a system combining fluorescence spectroscopy and machine learning through a convolutional neural network (CNN) to identify the origins of various Japanese green teas (Sayama tea, Kakegawa tea, Yame tea, and Chiran tea). Although food origin labeling is important for ensuring consumer quality and safety, ac-curate identification remains a priority for the food industry due to the emergence of problems with false origin labeling. In this study, image data of the fluorescent fingerprints of green teas were collected using fluorescence spectroscopy and analyzed using a C

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Susan, V. G., N. V. Litvinenko, I. V. Grekhova, T. M. Seredin, and N. M. Nimatulaev. "Reproduction of winter garlic air bulbs." Vegetable crops of Russia, no. 3 (June 28, 2021): 72–75. http://dx.doi.org/10.18619/2072-9146-2021-3-72-75.

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Relevance. It is possible to significantly increase the multiplication factor of varieties of winter garlic by growing from air bulbs (bulbs). For successful culture using air bulbs, it is very important to correctly determine the most productive fraction for each variety and calibrate it for sowing.Material and methodology. In our collection, there are more than 70 samples of winter garlic collected from different regions of Russia and two CIS countries. The air bulbs were calibrated using a set of round sieves with apertures of 3, 5, 7, 10 mm.Results. On average, the samples of the collectio

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Sasaki, Takayo, Tomoyuki Sawado, Masamitsu Yamaguchi та Tomoyuki Shinomiya. "Specification of Regions of DNA Replication Initiation during Embryogenesis in the 65-KilobaseDNApolα-dE2F Locus of Drosophila melanogaster". Molecular and Cellular Biology 19, № 1 (1999): 547–55. http://dx.doi.org/10.1128/mcb.19.1.547.

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ABSTRACT In the early stage of Drosophila embryogenesis, DNA replication initiates at unspecified sites in the chromosome. In contrast, DNA replication initiates in specified regions in cultured cells. We investigated when and where the initiation regions are specified during embryogenesis and compared them with those observed in cultured cells by two-dimensional gel methods. In the DNA polymerase α gene (DNApolα) locus, where an initiation region,oriDα, had been identified in cultured Kc cells, repression of origin activity in the coding region was detected after formation of cellular blastod

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Borst, Eva-Maria, and Martin Messerle. "Analysis of Human Cytomegalovirus oriLyt Sequence Requirements in the Context of the Viral Genome." Journal of Virology 79, no. 6 (2005): 3615–26. http://dx.doi.org/10.1128/jvi.79.6.3615-3626.2005.

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ABSTRACT During the lytic phase of infection, replication of herpesvirus genomes initiates at the lytic origin of replication, oriLyt. Many herpesviruses harbor more than one lytic origin, but so far, only one oriLyt has been identified for human cytomegalovirus (HCMV). Evidence for the existence of additional lytic origins of HCMV has remained elusive. On the basis of transient replication assays with cloned viral fragments, HCMV oriLyt was described as a core region of 1.5 kbp (minimal oriLyt) flanked by auxiliary sequences required for maximal replication activity (complete oriLyt). It rema

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Eladl, Afaf, Yudai Yamaoki, Shoko Hoshina, et al. "Investigation of the Interaction of Human Origin Recognition Complex Subunit 1 with G-Quadruplex DNAs of Human c-myc Promoter and Telomere Regions." International Journal of Molecular Sciences 22, no. 7 (2021): 3481. http://dx.doi.org/10.3390/ijms22073481.

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Origin recognition complex (ORC) binds to replication origins in eukaryotic DNAs and plays an important role in replication. Although yeast ORC is known to sequence-specifically bind to a replication origin, how human ORC recognizes a replication origin remains unknown. Previous genome-wide studies revealed that guanine (G)-rich sequences, potentially forming G-quadruplex (G4) structures, are present in most replication origins in human cells. We previously suggested that the region comprising residues 413–511 of human ORC subunit 1, hORC1413–511, binds preferentially to G-rich DNAs, which for

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Jovetić, Milica, Jelena Trifković, Dalibor Stanković, Dragan Manojlović, and Dušanka Milojković-Opsenica. "Mineral Content as a Tool for the Assessment of Honey Authenticity." Journal of AOAC INTERNATIONAL 100, no. 4 (2017): 862–70. http://dx.doi.org/10.5740/jaoacint.17-0145.

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Abstract The present work aims to provide a contribution to the overall investigation of European unifloral honeys with regard to authentication according to botanical and geographical origins. The mineral content of 206 monofloral honey samples of five botanical origins from six different regions in Serbia was investigated by inductively coupled plasma optical emission spectrometry. Chemometric techniques were applied for the classification and differentiation of acacia, sunflower, and linden honey according to botanical origin, as well as acacia honey samples according to regional origin. Th

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Bregman, Jesse D. "Observations of HII Regions and Planetary Nebulae: the Infrared Emission Bands." Symposium - International Astronomical Union 135 (1989): 109–18. http://dx.doi.org/10.1017/s0074180900125148.

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Advances in infrared spectrometers and the theory that PAHs are responsible for the infrared emission bands have led to a wealth of new information in recent years. High quality data have shown many weak emission bands which are diagnostic of the material producing the bands. While correlations of the strengths of the narrow bands indicate that a single material can account for all of the narrow bands, independent spatial behavior of the narrow and broad components show that they have different origins. Predictions of the behavior of the spectra based on laboratory data have been confirmed obs

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Lebofsky, Ronald, Roland Heilig, Max Sonnleitner, Jean Weissenbach, and Aaron Bensimon. "DNA Replication Origin Interference Increases the Spacing between Initiation Events in Human Cells." Molecular Biology of the Cell 17, no. 12 (2006): 5337–45. http://dx.doi.org/10.1091/mbc.e06-04-0298.

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Mammalian DNA replication origins localize to sites that range from base pairs to tens of kilobases. A regular distribution of initiations in individual cell cycles suggests that only a limited number of these numerous potential start sites are converted into activated origins. Origin interference can silence redundant origins; however, it is currently unknown whether interference participates in spacing functional human initiation events. By using a novel hybridization strategy, genomic Morse code, on single combed DNA molecules from primary keratinocytes, we report the initiation sites prese

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Göritz, D., and M. Kiss. "On the Origin of Strain-Induced Crystallization." Rubber Chemistry and Technology 59, no. 1 (1986): 40–45. http://dx.doi.org/10.5254/1.3538187.

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Abstract DSC measurements on stretched polybutadiene held at fixed length show two melting regions. The first is shifted a small amount to higher temperatures relative to the isotropic endotherms. The occurrence of two melting regions is considered to be evidence for an inhomogeneous deformation of the rubber. The melting point increases on stretching are taken to be due to entropy effects.

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Redondi, Renato, Paolo Malighetti, and Stefano Paleari. "THE ACCESSIBILITY OF EUROPEAN REGIONS AND AIRPORT NETWORK." Journal of Air Transport Studies 6, no. 2 (2015): 87–109. http://dx.doi.org/10.38008/jats.v6i2.60.

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The objective of this work is to evaluate the accessibility of European municipalities by air transport. We focus on travels that typically require the use of air transport by computing the quickest paths between any pair of municipalities separated by more than 500 km. The total travel time includes three components: i) travel by car or High Speed Train to reach the origin airport, ii) travel by air from the origin airport to the destination airport, including waiting times when no direct flight is available and iii) travel by car or High Speed Train from the destination airport to the munici

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Campbell, Caitlin J., Matthew C. Fitzpatrick, Hannah B. Vander Zanden, and David M. Nelson. "Advancing interpretation of stable isotope assignment maps: comparing and summarizing origins of known-provenance migratory bats." Animal Migration 7, no. 1 (2020): 27–41. http://dx.doi.org/10.1515/ami-2020-0004.

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AbstractProbability-of-origin maps deduced from stable isotope data are important for inferring broad-scale patterns of animal migration, but few resources and tools for interpreting and validating these maps exist. For example, quantitative tools for comparing multiple probability-of-origin maps do not exist, and many existing approaches for geographic assignment of individuals have not been validated or compared with respect to precision and accuracy. To address these challenges, we created and analyzed probability-of-origin maps using stable hydrogen isotope values from known-origin individ

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Boos, Dominik, and Pedro Ferreira. "Origin Firing Regulations to Control Genome Replication Timing." Genes 10, no. 3 (2019): 199. http://dx.doi.org/10.3390/genes10030199.

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Complete genome duplication is essential for genetic homeostasis over successive cell generations. Higher eukaryotes possess a complex genome replication program that involves replicating the genome in units of individual chromatin domains with a reproducible order or timing. Two types of replication origin firing regulations ensure complete and well-timed domain-wise genome replication: (1) the timing of origin firing within a domain must be determined and (2) enough origins must fire with appropriate positioning in a short time window to avoid inter-origin gaps too large to be fully copied.

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Gella, Pablo, Margarita Salas та Mario Mencía. "Improved artificial origins for phage Φ29 terminal protein-primed replication. Insights into early replication events". Nucleic Acids Research 42, № 15 (2014): 9792–806. http://dx.doi.org/10.1093/nar/gku660.

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Abstract The replication machinery of bacteriophage Φ29 is a paradigm for protein-primed replication and it holds great potential for applied purposes. To better understand the early replication events and to find improved origins for DNA amplification based on the Φ29 system, we have studied the end-structure of a double-stranded DNA replication origin. We have observed that the strength of the origin is determined by a combination of factors. The strongest origin (30-fold respect to wt) has the sequence CCC at the 3′ end of the template strand, AAA at the 5′ end of the non-template strand an

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Swigonova, Zuzana, Jinsheng Lai, Jianxin Ma, et al. "On the Tetraploid Origin of the Maize Genome." Comparative and Functional Genomics 5, no. 3 (2004): 281–84. http://dx.doi.org/10.1002/cfg.395.

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Data from cytological and genetic mapping studies suggest that maize arose as a tetraploid. Two previous studies investigating the most likely mode of maize origin arrived at different conclusions. Gaut and Doebley [7] proposed a segmental allotetraploid origin of the maize genome and estimated that the two maize progenitors diverged at 20.5 million years ago (mya). In a similar study, using larger data set, Brendel and colleagues (quoted in [8]) suggested a single genome duplication at 16 mya. One of the key components of such analyses is to examine sequence divergence among strictly ortholog

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Nardi, Francesco, Antonio Carapelli, and Francesco Frati. "Repeated regions in mitochondrial genomes: Distribution, origin and evolutionary significance." Mitochondrion 12, no. 5 (2012): 483–91. http://dx.doi.org/10.1016/j.mito.2012.07.105.

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Kirsch, Lior, and Gal Chechik. "On Expression Patterns and Developmental Origin of Human Brain Regions." PLOS Computational Biology 12, no. 8 (2016): e1005064. http://dx.doi.org/10.1371/journal.pcbi.1005064.

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Mininni, C., F. Fontani, V. M. Rivilla, M. T. Beltrán, P. Caselli, and A. Vasyunin. "On the origin of phosphorus nitride in star-forming regions." Monthly Notices of the Royal Astronomical Society: Letters 476, no. 1 (2018): L39—L44. http://dx.doi.org/10.1093/mnrasl/sly026.

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Dalmasse, K., G. Aulanier, P. Démoulin, B. Kliem, T. Török, and E. Pariat. "THE ORIGIN OF NET ELECTRIC CURRENTS IN SOLAR ACTIVE REGIONS." Astrophysical Journal 810, no. 1 (2015): 17. http://dx.doi.org/10.1088/0004-637x/810/1/17.

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Romagnano, Maryann A., Jonathan Braiman, Mario Loomis, and Robert W. Hamill. "Enkephalin fibers in autonomic nuclear regions: Intraspinal vs. supraspinal origin." Journal of Comparative Neurology 266, no. 3 (1987): 319–31. http://dx.doi.org/10.1002/cne.902660303.

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Lee, D. G., and S. P. Bell. "Architecture of the yeast origin recognition complex bound to origins of DNA replication." Molecular and Cellular Biology 17, no. 12 (1997): 7159–68. http://dx.doi.org/10.1128/mcb.17.12.7159.

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In many organisms, the replication of DNA requires the binding of a protein called the initiator to DNA sites referred to as origins of replication. Analyses of multiple initiator proteins bound to their cognate origins have provided important insights into the mechanism by which DNA replication is initiated. To extend this level of analysis to the study of eukaryotic chromosomal replication, we have investigated the architecture of the Saccharomyces cerevisiae origin recognition complex (ORC) bound to yeast origins of replication. Determination of DNA residues important for ORC-origin associa

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Karnani, Neerja, Christopher M. Taylor, Ankit Malhotra, and Anindya Dutta. "Genomic Study of Replication Initiation in Human Chromosomes Reveals the Influence of Transcription Regulation and Chromatin Structure on Origin Selection." Molecular Biology of the Cell 21, no. 3 (2010): 393–404. http://dx.doi.org/10.1091/mbc.e09-08-0707.

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DNA replication in metazoans initiates from multiple chromosomal loci called origins. Currently, there are two methods to purify origin-centered nascent strands: lambda exonuclease digestion and anti-bromodeoxyuridine immunoprecipitation. Because both methods have unique strengths and limitations, we purified nascent strands by both methods, hybridized them independently to tiling arrays (1% genome) and compared the data to have an accurate view of genome-wide origin distribution. By this criterion, we identified 150 new origins that were reproducible across the methods. Examination of a subse

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Aparicio, Jennifer G., Christopher J. Viggiani, Daniel G. Gibson, and Oscar M. Aparicio. "The Rpd3-Sin3 Histone Deacetylase Regulates Replication Timing and Enables Intra-S Origin Control in Saccharomyces cerevisiae." Molecular and Cellular Biology 24, no. 11 (2004): 4769–80. http://dx.doi.org/10.1128/mcb.24.11.4769-4780.2004.

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ABSTRACT The replication of eukaryotic genomes follows a temporally staged program, in which late origin firing often occurs within domains of altered chromatin structure(s) and silenced genes. Histone deacetylation functions in gene silencing in some late-replicating regions, prompting an investigation of the role of histone deacetylation in replication timing control in Saccharomyces cerevisiae. Deletion of the histone deacetylase Rpd3 or its interacting partner Sin3 caused early activation of late origins at internal chromosomal loci but did not alter the initiation timing of early origins

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Malbet, Fabien. "Inner disk regions revealed by infrared interferometry." Proceedings of the International Astronomical Union 3, S243 (2007): 123–34. http://dx.doi.org/10.1017/s1743921307009489.

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AbstractI review the results obtained by long-baseline interferometry at infrared wavelengths on the innermost regions around young stars. These observations directly probe the location of the dust and gas in the disks. The characteristic sizes of these regions are found larger than previously thought. These results have motivated in part a new class of models of the inner disk structure. However the precise understanding of the origin of these low visibilities is still in debate. Mid-infrared observations have probed disk emission over a larger range of scales revealing mineralogy gradients i

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