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Journal articles on the topic 'Regression of lesion'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Airewele, Gladstone, Geoffrey Miller, Charles McCluggage, and Murali Chintagumpala. "Lesion Regression." Journal of Neurosurgery: Pediatrics 107, no. 1 (2007): 80–81. http://dx.doi.org/10.3171/ped-07/07/080.

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Gisca, Tudor, Iulian-Valentin Munteanu, Ingrid-Andrada Vasilache, et al. "A Prospective Study on the Progression, Recurrence, and Regression of Cervical Lesions: Assessing Various Screening Approaches." Journal of Clinical Medicine 13, no. 5 (2024): 1368. http://dx.doi.org/10.3390/jcm13051368.

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(1) Background: The prediction of cervical lesion evolution is a challenge for clinicians. This prospective study aimed to determine and compare the predictive accuracy of cytology, HPV genotyping, and p16/Ki67 dual staining alone or in combination with personal risk factors in the prediction of progression, regression, or persistence of cervical lesions in human papillomavirus (HPV)-infected patients; (2) Methods: This prospective study included HPV-positive patients with or without cervical lesions who underwent follow-up in a private clinic. We calculated the predictive performance of indiv

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Lee, Hsiu-Chi, Shih-Chieh Lin, Meng-Hsing Wu, and Shaw-Jenq Tsai. "Inhibiting NTRK2 signaling causes endometriotic lesion regression." Reproduction 161, no. 1 (2021): 11–19. http://dx.doi.org/10.1530/rep-20-0163.

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Endometriosis is a common gynecological disease in reproductive-age women. Although the hormone-dependent therapy is the first line treatment for endometriosis, it is not a curative regimen and associated with severe side-effects, which significantly decrease the life quality of affected individuals. To seek a target for treatment of endometriosis, we focused on plasma membrane proteins that are elevated in ectopic cells and exert beneficial effects in cell growth and survival. We performed bioinformatics analysis and identified the neurotrophic receptor tyrosine kinase 2 (NTRK2) as a potentia

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Pieper, Cari Maristela, Eliseu Aldrighi Münchow, and Evandro Piva. "Regression of large periapical lesion using calcium hydroxide therapy: a six-year follow-up case report." Brazilian Dental Science 18, no. 1 (2015): 17. http://dx.doi.org/10.14295/bds.2015.v18i1.1015.

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<span>Periradicular lesions occur in non-vital teeth as the result of a chronic aggression by the presence of microorganisms into the root canal, which may appear as a radiolucent lesion in the radiographic exam; treatment varies according to surgical or nonsurgical methods. This case report describes the regression of a periradicular lesion using a nonsurgical endodontic treatment in association with intracanal calcium hydroxide-based medicament. After patient examination and radiographic analysis, a 13 mm (in maximum diameter) radiolucent lesion was observed in tooth number 12. The end

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Brod, Staley A., J. William Lindsey, and Flavia Nelson. "Tumefactive demyelination: Clinical outcomes, lesion evolution and treatments." Multiple Sclerosis Journal - Experimental, Translational and Clinical 5, no. 2 (2019): 205521731985575. http://dx.doi.org/10.1177/2055217319855755.

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Objective Large demyelinating lesions with possible mass effect (tumefactive multiple sclerosis or tumefactive demyelination) can be mistaken for tumour-like space-occupying lesions suggesting a malignant outcome. Methods We reviewed our own experience of multiple sclerosis subjects ( n = 28) with tumefactive demyelination to determine the relationship between clinical outcomes and lesion evolution, clinical outcomes and their relationship to different therapies. Patients with central nervous system demyelinating disease were identified from our database over the last 10 years. Results No pati

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Opoku, Emmanuel, Stela Berisha, Gregory Brubaker, Peggy Robinet, and Jonathan D. Smith. "Oxidant resistant human apolipoprotein A-I functions similarly to the unmodified human isoform in delaying atherosclerosis progression and promoting atherosclerosis regression in hyperlipidemic mice." PLOS ONE 17, no. 2 (2022): e0259751. http://dx.doi.org/10.1371/journal.pone.0259751.

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Background Transgenic overexpression of apolipoprotein A-I (apoA1) has been shown to delay atherosclerosis lesion progression and promote lesion regression in mouse models; however, apoA1 is subject to oxidation by myeloperoxidase (MPO) and loss of function. The activity of oxidant resistant human apoA1 was compared to unmodified human apoA1 in mouse models of atherosclerosis progression and regression. Methods and results Human apoA1 and the MPO oxidant resistant 4WF isoform transgenic mice were bred to LDL receptor deficient (LDLr KO) mice and fed a western-type diet. High level expression o

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Sustova, Pavla, Birgit Engesæter, Irene Tveiterås Øvestad, et al. "The Predictive Impact of HPV Genotypes, Tumor Suppressors and Local Immune Response in the Regression of Cervical Intraepithelial Neoplasia 2-3: A Prospective Population-Based Cohort Study." International Journal of Molecular Sciences 26, no. 11 (2025): 5205. https://doi.org/10.3390/ijms26115205.

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Cervical intraepithelial neoplasia (CIN) is caused by human papillomavirus (HPV); however, factors such as HPV genotype and individual immune response may also contribute to its development. The loop electrosurgical excision procedure (LEEP) is a treatment for high-grade cervical intraepithelial neoplasia (CIN), as approximately 30% of these cases may progress to cancer. However, 20–40% of cases will regress spontaneously. HPV16 infection constitutes the highest risk for progression to cervical cancer and a lower probability of regression. Knowledge regarding the regression of lesions caused b

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Nitto, Keita, Hiroaki Abe, Yuka Hashimoto, Yutaro Yabuki, Mayu Arai, and Ryo Sato. "Relationship between post-stroke trunk function and brain lesion locations: A support vector regression lesion-symptom mapping study." Journal of Rehabilitation Medicine 57 (May 27, 2025): jrm42782. https://doi.org/10.2340/jrm.v57.42782.

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Objective: This study aimed to investigate the relationship between brain lesions and trunk function impairment in stroke patients. Design: Retrospective cohort study. Subjects/Patients: One hundred fifty-six first-time stroke patients admitted for rehabilitation between August 2021 and October 2023. Methods: Trunk function was assessed using the Trunk Control Test. Brain lesions were detected using magnetic resonance imaging scans. Support vector regression lesion-symptom mapping was used to identify brain lesions associated with trunk function on admission and discharge, adjusted for lesion

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Pillay, Devan, and Zainal Abidin Abdul Hamid. "Spontaneous Regression of Ostial Coronary Artery Lesion." Asian Cardiovascular and Thoracic Annals 8, no. 4 (2000): 364–65. http://dx.doi.org/10.1177/021849230000800416.

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Yu, Qingqing, Panpan Wei, Liran Xu, et al. "Urotensin II Enhances Advanced Aortic Atherosclerosis Formation and Delays Plaque Regression in Hyperlipidemic Rabbits." International Journal of Molecular Sciences 24, no. 4 (2023): 3819. http://dx.doi.org/10.3390/ijms24043819.

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Accumulated evidence shows that elevated urotensin II (UII) levels are associated with cardiovascular diseases. However, the role of UII in the initiation, progression, and regression of atherosclerosis remains to be verified. Different stages of atherosclerosis were induced in rabbits by a 0.3% high cholesterol diet (HCD) feeding, and either UII (5.4 μg/kg/h) or saline was chronically infused via osmotic mini-pumps. UII promoted atherosclerotic fatty streak formation in ovariectomized female rabbits (34% increase in gross lesion and 93% increase in microscopic lesion), and in male rabbits (39

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Alzahrani, Saeed, Baidaa Al-Bander, and Waleed Al-Nuaimy. "Attention Mechanism Guided Deep Regression Model for Acne Severity Grading." Computers 11, no. 3 (2022): 31. http://dx.doi.org/10.3390/computers11030031.

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Acne vulgaris is the common form of acne that primarily affects adolescents, characterised by an eruption of inflammatory and/or non-inflammatory skin lesions. Accurate evaluation and severity grading of acne play a significant role in precise treatment for patients. Manual acne examination is typically conducted by dermatologists through visual inspection of the patient skin and counting the number of acne lesions. However, this task costs time and requires excessive effort by dermatologists. This paper presents automated acne counting and severity grading method from facial images. To this e

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Sen Saxena, Vivek, Prashant Johri, and Avneesh Kumar. "AI-Enabled Support System for Melanoma Detection and Classification." International Journal of Reliable and Quality E-Healthcare 10, no. 4 (2021): 58–75. http://dx.doi.org/10.4018/ijrqeh.2021100104.

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Skin lesion melanoma is the deadliest type of cancer. Artificial intelligence provides the power to classify skin lesions as melanoma and non-melanoma. The proposed system for melanoma detection and classification involves four steps: pre-processing, resizing all the images, removing noise and hair from dermoscopic images; image segmentation, identifying the lesion area; feature extraction, extracting features from segmented lesion and classification; and categorizing lesion as malignant (melanoma) and benign (non-melanoma). Modified GrabCut algorithm is employed to generate skin lesion. Segme

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Yahiaoui, Safia, Asma Ghorbel, Khadija Ben Zid, et al. "Spontaneous regression of an orbital Langerhans cell histiocytosis after biopsy: A case report. Spontaneous regression of an orbital Langerhans cell histiocytosis." Rare Tumors 14 (January 2022): 203636132211359. http://dx.doi.org/10.1177/20363613221135987.

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Langerhans histiocytosis or Langerhans cell histiocytosis (LCH) is a rare benign pathology representing less than 1% of orbital tumors. It can cause either localized or generalized lesions, leading to the destruction of hard and soft tissues. Eosinophilic granuloma is the most benign form and the predominant clinical presentation of LCH. We report a case of eosinophilic granuloma with orbital involvement in an 18-year-old male patient. Orbital radiotherapy was initially planned, but finally it was not performed due to a spontaneous regression of the lesion after the incisional biopsy. The pres

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Bailey, D. L., G. G. Adams, C. E. Tsao, et al. "Regression of Post-orthodontic Lesions by a Remineralizing Cream." Journal of Dental Research 88, no. 12 (2009): 1148–53. http://dx.doi.org/10.1177/0022034509347168.

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Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cream containing casein phosphopeptide- amorphous calcium phosphate compared with a placebo. Forty-five participants (aged 12–18 yrs) with 408 white-spot lesions were recruited, with 23 participants randomized to the remineralizing cream and 22 to the placebo. Product was applied twice daily after fluo

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Bumrungthai, Sureewan, Tipaya Ekalaksananan, Pilaiwan Kleebkaow, et al. "Mathematical Modelling of Cervical Precancerous Lesion Grade Risk Scores: Linear Regression Analysis of Cellular Protein Biomarkers and Human Papillomavirus E6/E7 RNA Staining Patterns." Diagnostics 13, no. 6 (2023): 1084. http://dx.doi.org/10.3390/diagnostics13061084.

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The current practice of determining histologic grade with a single molecular biomarker can facilitate differential diagnosis but cannot predict the risk of lesion progression. Cancer is caused by complex mechanisms, and no single biomarker can both make accurate diagnoses and predict progression risk. Modelling using multiple biomarkers can be used to derive scores for risk prediction. Mathematical models (MMs) may be capable of making predictions from biomarker data. Therefore, this study aimed to develop MM–based scores for predicting the risk of precancerous cervical lesion progression and

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Little, John R., and Anthony J. Furlan. "Resolving Occlusive Lesions of the Basilar Artery." Neurosurgery 17, no. 5 (1985): 811–14. http://dx.doi.org/10.1227/00006123-198511000-00015.

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Abstract Progression of severe basilar artery stenosis to occlusion is a well-recognized phenomenon, but regression of a severe basilar artery atherothrombotic lesion has not been described previously. In this report, two patients with a symptomatic severe basilar artery occlusive lesion showed substantial angiographic improvement after 3 months of anticoagulation in one case and 4 months after superficial temporal artery to superior cerebellar artery bypass in the other case. The findings in these cases indicate that clinical improvement in similar cases may reflect recanalization of a basila

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Dvorak, Elizabeth L., Davetrina S. Gadson, Elizabeth H. Lacey, Andrew T. DeMarco, and Peter E. Turkeltaub. "Domains of Health-Related Quality of Life Are Associated With Specific Deficits and Lesion Locations in Chronic Aphasia." Neurorehabilitation and Neural Repair 35, no. 7 (2021): 634–43. http://dx.doi.org/10.1177/15459683211017507.

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Background Health-related quality of life (HRQL) in stroke survivors is related to numerous factors, but more research is needed to delineate factors related to HRQL in people with aphasia. Objective To examine the relationship between HRQL and demographic factors, impairment-based measures, and lesion characteristics in chronic aphasia. Methods A total of 41 left-hemisphere stroke survivors with aphasia underwent cognitive testing and magnetic resonance imaging. To address relationships with demographic and impairment-based measures, test scores were entered into a principal component analysi

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Furby, J., T. Hayton, D. Altmann, et al. "Different white matter lesion characteristics correlate with distinct grey matter abnormalities on magnetic resonance imaging in secondary progressive multiple sclerosis." Multiple Sclerosis Journal 15, no. 6 (2009): 687–94. http://dx.doi.org/10.1177/1352458509103176.

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Background Although MRI measures of grey matter abnormality correlate with clinical disability in multiple sclerosis, it is uncertain whether grey matter abnormality measured on MRI is entirely due to a primary grey matter process or whether it is partly related to disease in the white matter. Methods To explore potential mechanisms of grey matter damage we assessed the relationship of white matter T2 lesion volume, T1 lesion volume, and mean lesion magnetisation transfer ratio (MTR), with MRI measures of tissue atrophy and MTR in the grey matter in 117 subjects with secondary progressive mult

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Sanchez-Flores, Xavier, Oscar W. Nevares-Pomales, and Rafael F. Martin-Garcia. "Nodular Lesion in a Newborn with Spontaneous Regression." Pediatrics in Review 42, no. 3 (2021): e9-e12. http://dx.doi.org/10.1542/pir.2018-0145.

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Zhang, Yongsheng, Daniel Y. Kimberg, H. Branch Coslett, Myrna F. Schwartz, and Ze Wang. "Multivariate lesion-symptom mapping using support vector regression." Human Brain Mapping 35, no. 12 (2014): 5861–76. http://dx.doi.org/10.1002/hbm.22590.

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Akrami, Haleh, Anand Joshi, Sergul Aydore, and Richard Leahy. "Deep Quantile Regression for Uncertainty Estimation in Unsupervised and Supervised Lesion Detection." Machine Learning for Biomedical Imaging 1, IPMI 2021 (2022): 1–23. http://dx.doi.org/10.59275/j.melba.2022-6751.

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Despite impressive state-of-the-art performance on a wide variety of machine learning tasks in multiple applications, deep learning methods can produce over-confident predictions, particularly with limited training data. Therefore, quantifying uncertainty is particularly important in critical applications such as lesion detection and clinical diagnosis, where a realistic assessment of uncertainty is essential in determining surgical margins, disease status and appropriate treatment. In this work, we propose a novel approach that uses quantile regression for quantifying aleatoric uncertainty in

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Rajan, Roy, and Sandeep Samant. "S155 – Spontaneous Regression of Mucosal Melanoma." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P128. http://dx.doi.org/10.1016/j.otohns.2008.05.329.

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Objectives Spontaneous regression of melanoma is a rare phenomenon, and it has yet to be described in the literature for mucosal melanomas, which ordinarily have a grim prognosis with a 10–15%, 5-year survival rate. We present a case of a hard palate melanoma that spontaneously regressed. Methods We present a case report, review of the literature, and a discussion. Results A 49-year-old female presented with a pigmented lesion recently on her hard palate that was biopsy-proven to be spindle-cell type malignant melanoma with a depth of 2.3 mm. It stained positive for S-100 and Melan-A. Subseque

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Polvinen, Eero, Markus Matilainen, Marjo Nylund, Marcus Sucksdorff, and Laura M. Airas. "TSPO-Detectable Chronic Active Lesions Predict Disease Progression in Multiple Sclerosis." Neurology - Neuroimmunology Neuroinflammation 10, no. 5 (2023): e200133. http://dx.doi.org/10.1212/nxi.0000000000200133.

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Background and ObjectivesIn the multiple sclerosis (MS) brain, chronic active lesions can be detected using MRI- and PET-based methods. In this study, we investigated whether the frequency of TSPO-PET–detectable chronic active lesions associates with disease progression measured using the Expanded Disability Status Scale (EDSS) at 5-year follow-up.MethodsChronic lesion–associated innate immune cell activation was evaluated using TSPO-PET in 82 patients with MS. Chronic lesions were categorized into rim-active, inactive, and overall active lesion subtypes based on innate immune cell activation

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Herwig-Carl, Martina C., and Karin U. Loeffler. "Regression of Periocular Basal Cell Carcinoma: A Report of Four Cases with Clinicopathologic Correlation." Ocular Oncology and Pathology 6, no. 2 (2019): 107–14. http://dx.doi.org/10.1159/000501370.

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Objectives: To describe the spectrum of clinical and histopathological features of a case series of basal cell carcinoma (BCC) with spontaneous regression and to discuss this phenomenon. Method: Four cases of BCC with complete/substantial regression were retrospectively identified. Patients’ records were analyzed for demographic data, clinical appearance, and the postoperative course. Formalin-fixed, paraffin-embedded specimens were routinely processed and stained with hematoxylin and eosin and periodic acid Schiff. Results: Complete (n = 1) or partial (n = 3) regression of BCC was observed in

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Cintra, Maria Leticia, Elemir Macedo de Souza, and Fernanda Mouro Fernandes. "Complete regression of melanocytic nevi: clues for proper diagnosis." Sao Paulo Medical Journal 112, no. 3 (1994): 597–601. http://dx.doi.org/10.1590/s1516-31801994000300005.

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A histopathological study of a distinct papule isolated from a patient's neck is reported and compared to 80 melanocytic nevi. The histogenesis of this unique tumor indicates that it probably represents the residual of a melanocytic nevus in wich nevi cells have disappeared but fat infiltration and fibrosis of the dermis and the typical aspects of other cutaneous elements persisted. The finding of focal acantholytic dyskeratosis in multiple foci of the lesion may indicate melanocytic cells regression. Lesions with the histopathological appearence of melanocytic nevi, even in the absence of nev

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Lourenço, Edmir Américo, and Luís Henrique Chechinato Costa. "Angyomatous vocal polypus: a complete spontaneous regression." Sao Paulo Medical Journal 114, no. 3 (1996): 1162–65. http://dx.doi.org/10.1590/s1516-31801996000300004.

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The authors describe a male patient who had malignant lymphoma seven years ago which remitted with chemotherapy.Two years ago he developed dysphonia. An unilateral, pediculate smooth red lesion on the right vocal fold was later discovered. Even without benefit of medicamentosus treatment, the patient refused surgery. In a reevaluation using rigid telescopy of the larynx two years later, the lesion had disappeared, completely and spontaneously. As there are no existing publications on this topic, this case report is an alert that surgery should be recommended with extreme caution in this type o

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Ung, Cindy, Inês Laíns, Rebecca F. Silverman, et al. "Evaluation of choroidal lesions with swept-source optical coherence tomography." British Journal of Ophthalmology 103, no. 1 (2018): 88–93. http://dx.doi.org/10.1136/bjophthalmol-2017-311586.

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AimsThe aim of our study was to image choroidal lesions with swept-source optical coherence tomography (SS-OCT) and to identify the morphological characteristics associated with optimal visualisation.MethodsThis was a prospective, cross-sectional study. Patients with choroidal melanocytic lesions <3 mm in thickness on B-scan ultrasonography were recruited. All participants underwent SS-OCT. On SS-OCT we evaluated qualitative (eg, lesion outline, detection of scleral-choroidal interface and quality of the image) and quantitative (measurement of maximum lesion thickness and the largest basal

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Letcă, Alina Florentina, Loredana Ungureanu, Lavinia Elena Grigore, Liliana Rogojan, and Rodica Cosgarea. "Melanoma with regression and in-transit metastasis." Medicine and Pharmacy Reports 89, no. 1 (2016): 165–68. http://dx.doi.org/10.15386/cjmed-525.

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Introduction. Melanoma is an aggressive tumor with an increasing incidence worldwide. In-transit metastases represent a unique pattern of dissemination.Case report. We report the case of a 42-year-old woman who presented with two lesions on the left latero-cervical region: a pigmented macule with irregular borders and colors and a firm, dome-shaped 5 mm nodule with an erythematous base and a black crust on top, at the periphery of the first lesion. The clinical picture supported the diagnosis of melanoma with in-transit metastasis, but the histopathology examination raised, initially, the prob

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Chung, Ho Yin, Jin Xian Huang, Kam Ho Lee, Helen Hoi Lun Tsang, Chak Sing Lau, and Shirley Chiu Wai Chan. "MRI lesions in SpA: a comparison with noninflammatory back pain using propensity score adjustment method." Therapeutic Advances in Musculoskeletal Disease 14 (January 2022): 1759720X2211192. http://dx.doi.org/10.1177/1759720x221119250.

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Background: Magnetic resonance imaging (MRI) is important in the management of axial spondyloarthritis (SpA). However, many MRI lesions are not exclusive to axial SpA. Further characterization of these lesions may lead to better clinical decisions. Objective: The objective of this study was to compare the frequency of individual spinal MRI lesions between axial SpA and noninflammatory back pain. The factors associated with individual lesions in participants with axial SpA were also determined. Design: This was a cross-sectional observational study. Methods: MRI lesions in 447 participants with

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Almeida, Ana C., Emília C. Fraga, Cristina P. Camacho, et al. "Gastric xanthelasma: case report." International Surgery Journal 7, no. 2 (2020): 594. http://dx.doi.org/10.18203/2349-2902.isj20200313.

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Xanthelasma, also known as Xanthoma or lipid island, is an uncommon gastrointestinal tract (GIT) tumor-like lesion and the stomach is its most frequent location in upper GI lesions, specifically in the gastric antrum, as a single lesion. The pathogenesis appears to be related to healing processes in response to tissue damage provoked by inflammation induced by Helicobacter pylori infection. Many studies have reported that successful H. pylori eradication helps prevent gastric cancer (GC) development. We present a case of a 77 years old patient that showed endoscopic diagnosis of erythematous g

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Muntinga, Caroline L. P., Peggy J. de Vos van Steenwijk, Ruud L. M. Bekkers, and Edith M. G. van Esch. "Importance of the Immune Microenvironment in the Spontaneous Regression of Cervical Squamous Intraepithelial Lesions (cSIL) and Implications for Immunotherapy." Journal of Clinical Medicine 11, no. 5 (2022): 1432. http://dx.doi.org/10.3390/jcm11051432.

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Cervical high-grade squamous intraepithelial lesions (cHSILs) develop as a result of a persistent high-risk human papilloma virus (hrHPV) infection. The natural course of cHSIL is hard to predict, depending on a multitude of viral, clinical, and immunological factors. Local immunity is pivotal in the pathogenesis, spontaneous regression, and progression of cervical dysplasia; however, the underlying mechanisms are unknown. The aim of this review is to outline the changes in the immune microenvironment in spontaneous regression, persistence, and responses to (immuno)therapy. In lesion persisten

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Ng Kee Kwong, Koy Chong, Daisy Mollison, Rozanna Meijboom, et al. "The prevalence of paramagnetic rim lesions in multiple sclerosis: A systematic review and meta-analysis." PLOS ONE 16, no. 9 (2021): e0256845. http://dx.doi.org/10.1371/journal.pone.0256845.

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Background Recent findings from several studies have shown that paramagnetic rim lesions identified using susceptibility-based MRI could represent potential diagnostic and prognostic biomarkers in multiple sclerosis (MS). Here, we perform a systematic review and meta-analysis of the existing literature to assess their pooled prevalence at lesion-level and patient-level. Methods Both database searching (PubMed and Embase) and handsearching were conducted to identify studies allowing the lesion-level and/or patient-level prevalence of rim lesions or chronic active lesions to be calculated. Poole

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Bhatia, SK, A. Goyal, P. Ritwik, and S. Rai. "Spontaneous Regression of a Congenital Epulis in a Newborn." Journal of Clinical Pediatric Dentistry 37, no. 3 (2013): 297–99. http://dx.doi.org/10.17796/jcpd.37.3.m1n1425821896807.

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A 3 day old girl presented with lobulated mass protruding from her mouth. The mass was clinically diagnosed as a congenital epulis. The child had no airway obstruction and was able to feed well. A conservative treatment was proposed with monthly follow up appointments to monitor the lesion. After 10 months the lesion completely regressed and the eruption of maxillary anterior teeth remained unaffected.

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Kamaraju, Sailaja, Blaise Bayer, Mingjin Chang, William Williams, Charles Wiseman, and Giuseppe Del Priore. "Abstract CT204: Efficacy of Bria-IMT regimen in inducing CNS metastasis regression." Cancer Research 84, no. 7_Supplement (2024): CT204. http://dx.doi.org/10.1158/1538-7445.am2024-ct204.

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Abstract Objectives: Breast cancer metastasis to the central nervous system (CNS) often leads to severe morbidity and mortality, and while systemic treatments manage primary tumors, their impact on CNS metastases is limited. This retrospective analysis evaluates the efficacy of Bria-IMT as a monotherapy or in combination with an immune checkpoint inhibitor (ICI) on CNS tumor regression. Methods: Post-hoc analysis of a subset of advanced MBC patients with CNS metastases from previous phase 1 and 2, and ongoing randomized phase 2 trials involving SV-BR-1-GM. SV-BR-1-GM is a GM-CSF secreting, ant

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Tanjung, Yulisa, Imelda Rey, and Masrul Lubis. "The Role of Folic Acid in Gastric Precancerous Lesion: A Literature Review." International Journal of Research and Review 11, no. 4 (2024): 404–11. http://dx.doi.org/10.52403/ijrr.20240444.

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Folic acid appears to hold promise as a potential preventive and therapeutic agent in gastric precancerous lesions. Folic acid, as an essential cofactor in DNA synthesis and methylation, plays a crucial role in maintaining genomic stability and regulating gene expression. It promotes DNA repair processes and protects against DNA damage, thereby inhibiting the initiation and progression of precancerous lesions. Moreover, folic acid acts as an antioxidant, mitigating oxidative stress and reducing inflammation in the gastric mucosa, which are key factors in the development of these lesions. Precl

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Al Safatli, Diaa, Rolf Kalff, and Albrecht Waschke. "Spontaneous Involution of a Presumably Rathke’s Cleft Cyst in a Patient with Slight Subclinical Hypopituitarism: A Case Report and Review of the Literature." Case Reports in Surgery 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/971364.

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Rathke cleft cyst is described as benign intrasellar cyst. They are mostly small and asymptomatic; they may become large enough to cause symptoms by compression of intrasellar or suprasellar structures. We report on a case of spontaneous regression of a symptomatic RCC with subsequent recovery of preexisting endocrine dysfunction and resolution of headaches. A 60-year-old man complained about headaches. Laboratory investigation revealed a partial hypopituitarism with a slight central hypothyroidism without need for substitution. An MRI study showed a cystic, T2-hyperintense, sellar lesion comp

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Chen, Dung-Tsa, Wenyaw Chan, Zachary J. Thompson, et al. "Utilization of target lesion heterogeneity for treatment efficacy assessment in late stage lung cancer." PLOS ONE 16, no. 7 (2021): e0252041. http://dx.doi.org/10.1371/journal.pone.0252041.

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Rationale Recent studies have discovered several unique tumor response subgroups outside of response classification by Response Evaluation Criteria for Solid Tumors (RECIST), such as mixed response and oligometastasis. These subtypes have a distinctive property, lesion heterogeneity defined as diversity of tumor growth profiles in RECIST target lesions. Furthermore, many cancer clinical trials have been activated to evaluate various treatment options for heterogeneity-related subgroups (e.g., 29 trials so far listed in clinicaltrials.gov for cancer patients with oligometastasis). Some of the t

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Nascimento, MM, AP Ribeiro, AJ Delgado, et al. "Temporary Tooth Separation to Improve Assessment of Approximal Caries Lesions: A School-Based Study." Operative Dentistry 45, no. 6 (2020): 581–88. http://dx.doi.org/10.2341/19-221-c.

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Clinical Relevance Radiographic lesion depth should not be used as the single determinant of the restorative threshold for clinically inaccessible approximal caries lesions. Temporary tooth separation is a feasible and effective diagnostic aid for assessment and appropriate management of approximal lesions. SUMMARY In the era of tooth-preserving dentistry, the decision to restore approximal caries lesions must be based on the accurate assessment of tooth cavitation, as the accumulation of oral biofilms in these areas encourages lesion progression. However, lesions radiographically into dentin

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Wu, Qian, Yi Chen, Miaoying Shen, et al. "Moderate to severe chronic arteriolar lesions is an independent risk factor for adverse renal outcomes in IgA nephropathy." PLOS One 20, no. 4 (2025): e0320635. https://doi.org/10.1371/journal.pone.0320635.

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Background The impact of chronic arteriolar lesions on the prognosis of IgA nephropathy remains controversial. This study aims to explore the value of chronic arteriolar lesions of varying degrees in predicting the prognosis of IgA nephropathy patients and analyze the associated risk factors that contribute to the formation. Methods A retrospective analysis was conducted on 853 patients diagnosed with IgA nephropathy through renal biopsy at Guangdong Provincial Hospital of Traditional Chinese Medicine between September 1, 2005, and December 31, 2021. Eventually, a total of 574 cases were inclu

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Snip, Olga S. C., Menno Hoekstra, Yiheng Zhang, Janine J. Geerling, and Miranda Van Eck. "2-Hydroxypropyl-beta-cyclodextrin Treatment Does Not Induce Atherosclerotic Lesion Regression in Western-Type Diet-Fed Apolipoprotein E Knockout Mice." Biomolecules 12, no. 9 (2022): 1205. http://dx.doi.org/10.3390/biom12091205.

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2-Hydroxypropyl-beta-cyclodextrin (2HPβCD) is able to bind and solubilize unesterified cholesterol and may therefore be able to reverse the deposition of cholesterol in macrophages within the aortic vessel wall, a hallmark of atherosclerotic cardiovascular disease. However, conflicting results regarding the potential of 2HPβCD to induce regression of established atherosclerotic lesions have been described. In the current study, we therefore also investigated the ability of 2HPβCD to stimulate cholesterol removal from macrophage foam cells in vitro and induce the regression of established ather

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Xiao, Maohua, Ziang Deng, You Ma, Shishuang Hou, and sanqin Zhao. "Ratings of Rice Leaf Blast Disease Based on Image Processing and Stepwise Regression." Applied Engineering in Agriculture 35, no. 6 (2019): 1037–43. http://dx.doi.org/10.13031/aea.13131.

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Abstract. Multi-feature fusion of morphology and texture featuresStepwise regression analysis to distinguish disease areas from natural brown areasCalculate the ratio of the total area of the diseased area to the area of the leaf area to obtain the disease level Abstract. In this research, an evaluation method involving digital image processing and stepwise regression was studied to establish an efficient and accurate rating system for studying rice blast disease. For this purpose, the R-G image was segmented by using maximum interclass variance method in which the lesion and naturally withere

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Alderov, Zaur A., Evgeny V. Rozengauz, and Denis Nesterov. "How CT reconstruction parameters effect measurement error of pulmonary nodules volume." HERALD of North-Western State Medical University named after I.I. Mechnikov 12, no. 3 (2020): 73–77. http://dx.doi.org/10.17816/mechnikov44920.

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One of the the widely used way to follow up oncological disease is estimation of lesion size differences. Volumetry is one of the most accurate approaches of lesion size estimation. However, being highly sensitive, volumetric errors can reach 60%, which significantly limits the applicability of the method. Purpose was to estimate the effect of reconstruction parameters on volumetry error. Materials and methods. 32 patients with pulmonary metastases underwent a CT scanning with 326 foci detected. 326 pulmonary were segmented. Volumetry error was estimated for every lesion with each

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&NA;. "Intensive lipid-lowering reduces lesion progression and increases regression." Inpharma Weekly &NA;, no. 763 (1990): 11. http://dx.doi.org/10.2165/00128413-199007630-00029.

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Shaharir, S. S., S. S. Osman, S. A. Md Rani, R. Sakthiswary, and M. S. M. Said. "Factors associated with increased white matter hyperintense lesion (WMHI) load in patients with systemic lupus erythematosus (SLE)." Lupus 27, no. 1 (2017): 25–32. http://dx.doi.org/10.1177/0961203317707062.

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Introduction White matter hyperintense (WMHI) lesions are the most common finding in magnetic resonance imaging (MRI) of the brain in patients with systemic lupus erythematosus (SLE). Objective The objective of this article is to determine the clinical factors associated with an increase in WMHI lesion load among SLE patients. Method A total of 83 SLE patients with MRI of the brain from National University of Malaysia Medical Centre were included. The WMHI lesion load was determined using the Scheltens score and Fazekas scale, and their distribution was divided into the deep white matter (DWMH

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Pai, Anuradha, Karthik D. Yadav, Ramakrishna T, and Abhishek B. "The harmless imitator of OSCC: TUGSE - traumatic ulcerative granuloma with stromal eosinophilia." International Journal of Dental Research 5, no. 2 (2017): 199. http://dx.doi.org/10.14419/ijdr.v5i2.8499.

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Traumatic Ulcerative Granuloma with Stromal Eosinophillia is a rare, benign, self-limiting and asymptomatic lesion that shows a spontaneous regression. Its etiopathogenesis is an enigma, but trauma seems to play a role for the occurrence of this lesion. Clinically it manifests as an isolated long standing lesion predominantly located in the tongue, demonstrating raised & indurated margins and mimicking oral squamous-cell carcinoma. Microscopically it is characterized by an inflammatory infiltrate rich in eosinophils. Since these lesions show delayed healing, treatment becomes necessary, bu

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Lan, Linfang, Haipeng Liu, Vincent Ip, et al. "Regional High Wall Shear Stress Associated With Stenosis Regression in Symptomatic Intracranial Atherosclerotic Disease." Stroke 51, no. 10 (2020): 3064–73. http://dx.doi.org/10.1161/strokeaha.120.030615.

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Background and Purpose: Understanding the mechanisms underlying progression/regression of symptomatic intracranial atherosclerotic stenosis (sICAS) will inform secondary prevention of the patients. Focal wall shear stress (WSS) may play an important role, which, however, had seldom been investigated. Methods: Patients with acute ischemic stroke or transient ischemic attack (TIA) attributed to 50% to 99% intracranial atherosclerotic stenosis were recruited. All patients underwent cerebral computed tomography angiography at baseline, and a computational fluid dynamics model was built based on co

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Pesce, Alessandro, Flavia Fraschetti, Giancarlo D'Andrea, et al. "Risk of Postoperative Performance Status Worsening after Resection of Lesions Involving the Motor Pathway: A Multinomial Logistic Regression Model." Journal of Neurological Surgery Part A: Central European Neurosurgery 79, no. 06 (2018): 453–63. http://dx.doi.org/10.1055/s-0037-1617756.

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Background and Study Objective In surgery for gliomas and brain metastases, preservation of neurologic functions is essential to ensure a good quality of life and the eligibility for adjuvant therapies. This article assesses which factors could influence the functional outcome in patients with lesions located in the motor pathways. Materials and Methods A total of 92 patients with gliomas and metastases involving the motor pathways were studied for concerns regarding quality of life (Karnofsky performance status [KPS] and modified Rankin scale [mRS]) before and after surgical treatment support

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Xu, Fan, Ying-ying Liang, Yuan Guo, et al. "Diagnostic performance of whole-lesion apparent diffusion coefficient histogram analysis metrics for differentiating benign and malignant breast lesions: a systematic review and diagnostic meta-analysis." Acta Radiologica 61, no. 9 (2020): 1165–75. http://dx.doi.org/10.1177/0284185119896520.

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Background Although whole-lesion apparent diffusion coefficient (ADC) histogram has been increasingly used for breast lesions, it has not been routinely used in clinical practice as an emergent promising imaging tool. Purpose To evaluate the performance of whole-lesion ADC histogram analysis metrics for differentiating benign and malignant breast lesions. Material and Methods A systematic PubMed/EMBASE/Cochrane electronic database search was performed for original diagnostic studies from 1 January 1970 to 2 January 2019. Summary estimates of diagnostic accuracy were generated and meta-regressi

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Ahmad, Sharique, Jata Shankar Misra, and Subuhi Anwar. "Biological Behaviour of Squamous Intraepithelial Lesion of Cervix Under Rural Conditions in Western Lucknow, India." Azerbaijan Pharmaceutical and Pharmacotherapy J 22, no. 1 (2023): 1–5. http://dx.doi.org/10.61336/appj/22-1-01.

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Objective: The biological behavior of squamous intraepithelial lesions (SIL) is uncertain as most of the lesions regress, and only some of them progress to higher grades or persist. This varied behavior is common under rural conditions due to the lack of progression-promoting agents like Human papillomavirus (HPV). Methods: Rural cervical cancer screening has been in progress for the last 8 years in the villages of West Lucknow through a camp approach, and to date, 2980 women have undergone cytological examination. Among them, 499 women were diagnosed with SIL, and 310 of these cases were foll

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Azam, M., C. Colasanti, J. Butler, M. Weiss, P. Brodeur, and J. Kennedy. "CLINICAL OUTCOMES OF AUTOLOGOUS OSTEOCHONDRAL TRANSPLANTATION FOR OSTEOCHONDRAL LESIONS OF THE TALUS: AN AGE-BASED MULTIVARIABLE ANALYSIS." Orthopaedic Proceedings 106-B, SUPP_12 (2024): 16. http://dx.doi.org/10.1302/1358-992x.2024.12.016.

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IntroductionThe purpose of this study was to examine trends in patient characteristics and clinical outcomes that occur with age as a statistical variable when performing autologous osteochondral transplantation (AOT) for the treatment of osteochondral lesions of the talus (OLT).MethodsA retrospective cohort study for AOT procedures on 78 patients from 2006 to 2019. was conducted Clinical outcomes were evaluated via FAOS scores. A multivariable linear regression was used to assess the independent factors predictive of the first post-operative FAOS after AOT. The independent variables included

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