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Dissertations / Theses on the topic 'Regulated kinase'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Raman, Malavika. "Identification of intracellular signaling pathways regulated by the TAO family of mammalian STE20p kinases." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=163.

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2

Probst, Brandon Linn. "Identification of substrates and pathways regulated by PAS kinase." Access to abstract only; dissertation is embargoed until after 12/20/2006, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=137.

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3

Gasser, Jessica Ann. "Serum and Glucocorticoid-Regulated Kinase Signaling in Breast Cancer." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11296.

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Oncogenic activating mutations in PIK3CA, the gene encoding the catalytic subunit of phosphoinositide 3-kinase (PI 3-K), are highly prevalent in breast cancer. The protein kinase Akt is considered to be the primary effector of PIK3CA, though the mechanisms by which PI 3-K mediates tumorigenic signals in an Akt-independent manner remain obscure. My studies show that the serum and glucocorticoid-regulated kinases (SGKs) can function as effectors of PI 3-kinase and transduce signals to phenotypes associated with malignancy. We show that SGK3 is amplified in breast cancer and identify the mechani

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4

Prescott, Gerald Robert. "The role of the kinase, Akt/PKBin regulated exocytosis." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479062.

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5

NADAL, WOLLBOLD FLORENCE. "Activation et regulation des map kinases extracellular signal-regulated kinase 2 et c-jun nh2-terminal kinase 1 dans les plaquettes humaines." Paris 7, 2000. http://www.theses.fr/2000PA077163.

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Les map kinases sont des serine/threonine kinases regroupees en trois familles : les extracellular signal-regulated kinases (erks), les c-jun nh2-terminal kinases (jnks) et les p38 m a p k s. Principalement activees par les recepteurs a activite tyrosine kinase, les recepteurs couples aux proteines g heterotrimeriques et les integrines, elles jouent un role important dans la proliferation, la differenciation, la migration et l'apoptose. Si l'activation, la regulation, et le role des map kinases sont tres etudiees dans les cellules proliferatrices, tres peu de travaux sont realises dans les cel

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6

Nekhoroshkova, Elena. "A-RAF kinase functions in ARF6 regulated endocytic membrane traffic." kostenfrei, 2009. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-44566.

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7

Wu, Jheng-Yu. "Regulation of Extracellular Signal-Regulated Kinase by Histone Deacetylase 6." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6985.

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Extracellular signal-regulated kinases 1/2 (ERK1/2) are important kinases regulating cell proliferation and cell migration, and have been established as therapeutic targets for cancer treatment. Previously, we found that ERK1 phosphorylates histone deacetylase 6 (HDAC6) to regulate its enzymatic activity. However, whether HDAC6 reciprocally modulates ERK1 activity is unknown. Here, we have discovered that ERK1/2 are acetylated proteins and shown that HDAC6 manipulates ERK1’s kinase activity via deacetylation. We demonstrated that both ERK1 and ERK2 interact with HDAC6 physically. We showed tha

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8

Peters, Marco. "The calcium-calmodulin regulated Kinase cascade in learning and memory." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406738.

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9

Dan, Yuzhen 1992. "Signaling networks regulated by the kinase p38α in cancer cell homeostasis". Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673710.

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p38α (encoded by MAPK14) is a major regulator of cellular responses to almost all types of environmental and intracellular stresses. Upon activation, p38α phosphorylates various substrates both in the cytoplasm and nucleus, allowing this pathway to regulate a wide variety of cellular processes, including cell proliferation, differentiation, or survival. Given the plethora of functions that can be controlled by p38α, we performed proteomic and phosphoproteomic analysis to study the signaling networks regulated by p38α during cancer cell homeostasis. Our study identifies 35 proteins and 114 phos

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10

Kulaberoglu, Y. "The functional characterisation of MOB1-regulated Hippo core cassette kinase signalling." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1537606/.

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The Hippo tumour suppressor pathway regulates tissue growth by co-ordinating cell death, proliferation and differentiation. The central Hippo core cassette consists of MST1/2, LATS1/2, NDR1/2 and MOB1, with recent studies of MOB1 knockout mice indicating MOB1 functions as the central hub of Hippo signalling. However, it has remained unknown which interactions of MOB1 with the Hippo core cassette kinases MST1/2, LATS1/2 and NDR1/2 are required for normal life and tumour suppression. Therefore, my PhD project focused on deciphering the complex protein-protein interactions of MOB1 with MST1/2, LA

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11

Lombardi, Zoe. "Optimization of Extracellular signal-regulated kinase 5 (ERK5) targeting in melanoma." Doctoral thesis, Università di Siena, 2023. https://hdl.handle.net/11365/1227476.

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Melanoma is the deadliest skin cancer with a very poor prognosis in advanced stages. Although targeted and immune therapies have improved survival, not all patients benefit from these treatments. It has been reported that the mitogen-activated protein kinase ERK5 is consistently express in human melanoma and supports melanoma cell proliferation in vitro and in vivo. However, ERK5 inhibition results in cell-cycle arrest rather than appreciable apoptosis. To clarify the role of ERK5 in melanoma growth, we performed transcriptomic analyses following ERK5 knockdown in melanoma cells expressing BRA

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12

Da, Silva Xavier Gabriela. "Glucose-regulated gene transcription in pancreatic islet #beta#-cells." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340080.

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13

Elias, Demetra. "Characterization of ES147, a salt stress regulated protein kinase from Lophopyrum elongatum." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ59271.pdf.

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14

Uhiara, Chukwuemeka Obinna. "The role of extracellular signal-regulated kinase in beta-adrenoceptor-mediated vasodilatation." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12695/.

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Beta-Adrenoceptors (B-ARs) mediate vasodilatation by activating various mechanisms that collectively contribute to vascular smooth muscle (VSM) relaxation. It has been shown that B2-AR stimulation in cultured cells results in activation of extracellular signal-regulated kinase (ERK). As the functional relevance of this was not known, the aim of the current investigation was determine the role of ERK in beta-AR-mediated vasodilatation. Isoprenaline-induced relaxation of porcine coronary artery (PCA) segments pre-contracted with the thromboxane mimetic U46619 was significantly enhanced by inhibi

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15

McNee, Gavin Scott. "p38 MAP kinase regulated PLD1 activity controls stress-induced EGF receptor internalisation." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611445.

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16

Azzam, Diana Galil. "Extracellular signal regulated kinase/mitogen activated protein kinase (ERK/MAPK) regulation of the androgen receptor in breast cancer cells." University of Western Australia. School of Pathology and Laboratory Medicine, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0024.

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[Truncated abstract] Androgens inhibit the growth of human breast tumours and have been successfully used to treat breast cancer in women. Expression of the androgen receptor (AR), which mediates androgen action, is upregulated in breast cancer cells and the AR is the most frequently expressed steroid hormone receptor in breast tumours. AR levels and activity are modulated by the activity of other signalling pathways, however interactions between the AR and signalling pathways and the consequent alterations to the androgen responsiveness of breast cancer cells are largely uncharacterised. The

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17

Cao, Yang. "Macromolecular crowding effects on the activity of the extracellular signal regulated kinase 2 /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202008%20CAO.

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18

Jay, Jennifer L. "JAK2 Tyrosine Kinase Phosphorylates and is Negatively Regulated by the Centrosomal Protein Ninein." University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1430503844.

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19

Elkhadragy, Lobna. "Regulation of the expression and activity of Extracellular signal-regulated kinase 3 (ERK3)." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright151359030649182.

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20

Ulm, Susanne. "The role of Extracellular-Regulated Protein Kinase 2 (ERK2) in cardiac hypertrophic remodelling." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-extracellularregulated-protein-kinase-2-erk2-in-cardiac-hypertrophic-remodelling(32588ceb-7199-4482-a764-802875505e09).html.

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Cardiac hypertrophy is a response to increased mechanical demand on the heart. Initially hypertrophy is beneficial by reducing stress on the ventricular wall. However, sustained stress on the heart results in pathological hypertrophy which is characterised by re-induction of the fetal gene program, interstitial fibrosis, cardiomyocyte apoptosis, chamber dilation and eventually, heart failure. In contrast, exercise and pregnancy are considered to cause physiological hypertrophy with preservation of normal cardiac structure. The precise mechanism behind two different hypertrophy types remains un

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21

Kuß, Martin [Verfasser], and Philipp J. [Akademischer Betreuer] Kahle. "Interferon gamma induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 / Martin Kuß ; Betreuer: Philipp J. Kahle." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1197057234/34.

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22

Salery, Marine. "Rôle de la protéine Arc (Activity-regulated cytoskeleton-associated protein) dans les adaptations moléculaires et comportementales induites par la cocaïne." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066400/document.

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Les adaptations cellulaires et moléculaires induites par les drogues jouent un rôle central dans les altérations comportementales à long terme observées dans l’addiction. Cette étude s’inscrit dans une démarche de compréhension des processus cellulaires rapidement mis en jeu par la cocaïne et susceptibles d’impacter durablement le fonctionnement neuronal et les comportements. La protéine Arc joue un rôle clé dans l’établissement de la plasticité synaptique à long-terme et la consolidation de la mémoire. Cette étude visait à caractériser l’induction de Arc dans le striatum en réponse à la cocaï

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23

Badal, Bryan D. "Snf1 Mediated Phosphorylation and Activation of PAS Kinase." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4245.

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Nutrient sensing kinases sense available nutrients and regulate cell activity accordingly. Three of these enzymes are AMP regulated kinase (AMPK, or Snf1 in yeast), PAS kinase, and target of rapamycin (TOR), are conserved from yeast to man and have overlapping function. AMPK and Snf1 are important in sensing when nutrient status in the cell is low and down regulating energy consuming pathways. PAS kinase is required for glucose homeostasis in the cell, and responds to glucose levels. TOR senses nutrients such as amino acids and upregulates cell growth pathways primarily through protein synthes

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24

Maitra, Sushmit. "The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase activated protein kinase 2." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008r/maitra.pdf.

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25

Larsson, Anna. "Histone modification regulated bysuppressor of Zeste 12 and Ipl1 : Aurora-like kinase in Drosophila." Licentiate thesis, Umeå University, Department of Molecular Biology (Faculty of Science and Technology), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36214.

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<p>Polycomb group (PcG) proteins are a group of genome wide silencers that are crucial for many processes during the development. In Drosophila PcG proteins are organised into four different complexes: PRC1, PRC2, PhoRC and PR-DUB. PRC2 consists of four core proteins: Su(z)12, E(z), Esc and Nurf. E(z) is the only known proteins with a known function, it possess a methyltransferase activity that specifically methylates lysine 27 on histone 3 (H3K27). A novel PcG gene was identified in 2001 in screen for modifiers of zeste-white interaction. This gene suppressed zeste’s repression of white and g

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26

Roberts, Owain Llyr. "The role of the extracellular signal-regulated kinase 5 (ERK5) signalling axis in angiogenesis." Thesis, Bangor University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520822.

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27

Badshah, Irbaz Isaac. "Extracellular signal-regulated kinase 5 in human podocytes : the effects of a diabetic milieu." Thesis, St George's, University of London, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.676892.

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INTRODUCTION: Podocytes are specialised cells integral to the normal functioning kidney. As a consequence of diabetes podocyte dysfunction, phenotype impairment, and podocytopaenia occur. The ERK5 MAPK is involved in cell survival, proliferation, differentiation, and motility; processes central to the pathologies of diabetic nephropathy. AIMS: To establish an in vitro cellular model for studying the MEK5-ERK5 pathway in human podocytes and its regulation by diabetes-associated stimuli. METHODS: Conditionally immortalised human podocytes were treated with EGF (1.25-10 ng/ml), TGF B1 (1.25-10 ng

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28

Ullanat, Rajesh. "Light-And Cytokinin-Regulated Plastid And Nuclear Gene Expression In Cucumber (Cucumis Sativus L)." Thesis, Indian Institute of Science, 2000. https://etd.iisc.ac.in/handle/2005/170.

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Light and phytohormones, such as cytokinins, have been known to play a pivotal role in numerous physiological processes in plant cells. Previous work in our laboratory has revealed the light- and cytokinin- modulated changes both in the levels of specific tRNA species and their modified nucleotide contents, in addition to the characterization of specific tRNAs and tRNA genes from higher plants. The plant hormone cytokinin, which is of particular interest to us has been implicated to be involved in processes such as induction of cell division, plastid biogenesis and delay of senescence. Ongoing

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Ullanat, Rajesh. "Light-And Cytokinin-Regulated Plastid And Nuclear Gene Expression In Cucumber (Cucumis Sativus L)." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/170.

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Light and phytohormones, such as cytokinins, have been known to play a pivotal role in numerous physiological processes in plant cells. Previous work in our laboratory has revealed the light- and cytokinin- modulated changes both in the levels of specific tRNA species and their modified nucleotide contents, in addition to the characterization of specific tRNAs and tRNA genes from higher plants. The plant hormone cytokinin, which is of particular interest to us has been implicated to be involved in processes such as induction of cell division, plastid biogenesis and delay of senescence. Ongoing

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30

Borysov, Sergiy I. "B-Raf is an essential component of the mitotic machinery critical for activation of MAPK signaling during mitosis in Xenopus egg extracts." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001759.

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31

Freeman, Alyson. "CHK2 is Negatively Regulated by Protein Phosphatase 2A." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3443.

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Checkpoint kinase 2 (CHK2) is an effector kinase of the DNA damage response pathway and although its mechanism of activation has been well studied, the attenuation of its activity following DNA damage has not been explored. Here, we identify the B'α subunit of protein phosphatase 2A (PP2A), a major protein serine/threonine phosphatase of the cell, as a CHK2 binding partner and show that their interaction is modulated by DNA damage. B'α binds to the SQ/TQ cluster domain of CHK2, which is a target of ATM phosphorylation. CHK2 is able to bind to many B' subunits as well as the PP2A C subunit, ind

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32

Choksi, Nidhi Rajan. "Characterizing Interaction Between PASK and PBP1/ ATXN2 to Regulate Cell Growth and Proliferation." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6527.

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Pbp1 is a component of glucose deprivation induced stress granules and is involved in P-body-dependent granule assembly. We have recently shown that Pbp1 plays an important role in the interplay between three sensory protein kinases in yeast: AMP-regulated kinase (Snf1 in yeast), PAS kinase 1 (Psk1 in yeast), and the target of rapamycin complex 1 (TORC1), to regulate glucose allocation during nutrient depletion. This signaling cascade occurs through the SNF1-dependent phosphorylation and activation of Psk1, which phosphorylates and activates poly(A)- binding protein binding protein 1 (Pbp1), w

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33

Wang, Yupeng. "Regulation and function of BDNF-activated ERK5 and ERK1/2 MAP kinases in CNS neurons /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8455.

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34

Sakwe, Amos M. "The Role of Protein Kinase C in the Extracellular Ca2+-regulated Secretion of Parathyroid Hormone." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4637.

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Parathyroid hormone (PTH) is the major physiological regulator of the extracellular Ca2+ concentration ([Ca2+]o) in the body. The secretion of this hormone is suppressed at high [Ca2+]o. Previously this was thought to occur by intracellular degradation of the hormone in the secretory pathway of parathyroid (PT) cells but is now believed to result from extracellular Ca2+ stimulus-secretion coupling via the calcium sensing receptor (CaR). In contrast to the stimulation of PTH secretion upon inhibition of mature PTH proteolysis, inhibition of PT proteasomes caused the accumulation of PTH precurso

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35

Sipieter, François. "Development and validation of kinase activity reporters for the dynamical study of cell response modalities by microscopy : Role of the Mitogen-Activated Protein Kinase / Extracellular signal-Regulated Kinase in necroptosis." Thesis, Lille 1, 2015. http://www.theses.fr/2015LIL10167.

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La nécroptose est une mort programmée caspase indépendante, induite par le Tumor Necrosis Factor alpha (TNFα) et fait intervenir une voie de signalisation impliquant deux kinases, les Receptor-Interacting Protein Kinases 1 et 3 (RIPK1 et RIPK3) et la pseudo-kinase Mixed Lineage Kinase domain-Like protein (MLKL). L’activation des kinases Extracellular signal-Regulated Kinase 1 et 2 (ERK1/2) a été rapportée dans plusieurs morts cellulaires programmées. Par ailleurs, la régulation de l’activité de ERK1/2 en termes d’amplitude, de durée et de localisation via des régulateurs spatio-temporels spéci

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36

Mouhamad, Shahul. "Mécanismes régulateurs de la prolifération et de l'apoptose lymphocytaire : Etude du rôle de la MAPK (Mitogen Actived Protein Kinase) : Erk (Extracellular Signal-regulated kinase)." Paris 11, 2004. http://www.theses.fr/2004PA11TO56.

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37

Billiard, Julia. "New stimulators and a new mechanism of regulated secretion in pituitary gonadotropes /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/10544.

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38

Williams, Kendra Allana. "Phosphorylation of Histone Deacetylase 6 within its C-terminal Region by Extracellular Signal Regulated Kinase 1." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4792.

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39

Valenciano, Murillo Ana Lisa. "Biological and biochemical characterization of the extracellular signal-regulated kinase 8 homolog (TbERK8) in Trypanosoma brucei." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/79769.

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Trypanosoma brucei species are vector-borne protozoan parasites that cause Human African typanosomiasis (HAT) and nagana in cattle. In humans, the diseases caused by these parasites are fatal if left untreated. Treatments for these diseases are complicated because the approved drugs for treatment are ineffective against the parasites and have many toxic side effects associated with their use. There is a clear need to identify new therapeutics that are less toxic and more effective against T. brucei. Our approach for identifying new therapies is to identify novel targets in the parasite that ca

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40

Stirling, Lee. "Dual Roles for Rhoa/Rho-Kinase in the Regulated Trafficking of a Voltage-Sensitive Potassium Channel." ScholarWorks @ UVM, 2009. http://scholarworks.uvm.edu/graddis/223.

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Kv1.2 is a member of the Shaker family of voltage-sensitive potassium channels and contributes to regulation of membrane excitability. The electrophysiological activity of Kv1.2 undergoes tyrosine kinase-dependent suppression in a process involving RhoA. We report that RhoA elicits suppression of Kv1.2 ionic current by modulating channel endocytosis. This occurs through two distinct pathways, one clathrin-dependent and the other cholesterol-dependent. Activation of RhoA downstream effectors Rho-kinase (ROCK) or protein kinase N (PKN) via the lysophosphatidic acid (LPA) receptor elicits clathri

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41

Hiratsuka, Toru. "Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin." Kyoto University, 2015. http://hdl.handle.net/2433/199209.

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42

Dinev, Dragomir. "Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells." Doctoral thesis, [S.l.] : [s.n.], 2001. https://nbn-resolving.org/urn:nbn:de:bvb:20-1180481.

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The MEK5/ ERK5 kinase module is a relatively new discovered mitogen-activated protein kinase (MAPK) signalling pathway with a poorly defined physiological function. Since ERK5 and its upstream activator MEK5 are abundant in skeletal muscle a function of the cascade during muscle differentiation was examined. ERK5 becomes activated upon induction of differentiation in mouse myoblasts. The selective activation of the pathway results in promoter activation of differentiation-specific genes, such as the cdk-inhibitor p21 gene, the myosin light chain (MLC1A) gene, or an E-box containing promoter el

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43

Schroyer, April L. "The Regulation of Mixed Lineage Kinase 3 by Extracellular Signal-Regulated Kinases 1 and 2 and Stress Stimuli in Colorectal and Ovarian Cancer Cells." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1513345931716064.

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44

Sano, Takeshi. "Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225467.

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45

Hall, Ben Alexander. "The identification and characterisation of novel serum and glucocorticoid regulated kinase 1 (SGK1) isoforms in human skin." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442326.

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46

Konishi, Yoshinobu. "Live-cell FRET imaging reveals a role of extracellular signal-regulated kinase activity dynamics in thymocyte motility." Kyoto University, 2019. http://hdl.handle.net/2433/242374.

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47

Conway, Ann Marie. "Growth factor receptor tyrosine kinase-, G-protein coupled receptor- and sphingolipid-dependent regulation of the extracellular signal-regulated kinase cascade in cultured airway smooth muscle cells." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366970.

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48

Maddali, Kamala Kalyani. "A mandatory requirement of PKC-[delta] in testosterone regulated coronary smooth muscle cell differentiation, proliferation and apoptosis /." Free to MU Campus, others may purchase, 2005. http://proquest.umi.com/pqdweb?did=1232392431&sid=1&Fmt=2&clientId=45247&RQT=309&VName=PQD.

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49

Houri, Nadia. "Study of ERK12 MAP kinases activation by the bradykinin type 2 receptor : characterization of beta-arrestin scaffolding function in the temporal regulation of ERK12 activation induced by the B2R." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112637.

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G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors. The beta-arrestins, adaptor proteins involved in GPCR desensitization, may also act as scaffolds for signaling pathways such as the mitogen-activated protein kinase (MAPK) cascade. The MAPK family, which includes the extracellular-signal regulated kinases (ERK) 1 and 2, promotes cellular differentiation and proliferation. Herein, the activation of ERK1/2 upon stimulation of the GPCR bradykinin type 2 receptor (B2R) with bradykinin was examined. Various B2R mutants with modified C-termini were employed t

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50

Sakwe, Amos M. "The Role of Protein Kinase C in the Extracellular Ca²⁺-regulated Secretion of Parathyroid Hormone." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4637.

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