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Journal articles on the topic 'Regulation n°4/2009'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Polskaya, N. A. "Self-injurious acts in patients with bordeline personality disorders." Experimental Psychology (Russia) 8, no. 3 (2015): 129–44. http://dx.doi.org/10.17759/exppsy.2015080312.

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Results of the empirical study on the relation between emotion regulation factors and the peculiarity of self-injurious behavior in clinical and nonclinical groups are reported. Participants of the research (N=68) comprised two groups: inpatients with borderline personality disorders (N=33; М=44,9, SD=10,8) and control group (N=35; M=39,3, SD=11,2). Methods: the scale of reasons for self-injurious behavior (Polskaya, 2014), Cognitive Emotion Regulation Questionnaire (Garnefski et al., 2002, Rasskazova et al., 2011), the Ways of Coping Questionnaire (Lazarus, Folkman, 1988, Kryukova, Kuftyak, 2

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Pangestuti, Retno, Anissa Lestari Kadiyono, Surya Cahyadi, and Hendriati Agustiani. "A Modifying the Instrument of Self-Regulation in Early Childhood Assessment." JPUD - Jurnal Pendidikan Usia Dini 13, no. 1 (2019): 114–27. http://dx.doi.org/10.21009/10.21009/jpud.131.09.

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Self-regulation for pre-school children is very important to support children’s adjustments in all situations and conditions. The current problem is the instrument of self-regulation is more focused on regulation in learning which is not suitable for young children. This study aims to examine the validity and reliability of Preschool Self-Regulation Assessment (PSRA) in Indonesia by modifying several children self-regulation theories. The instrument was translated from English into Indonesian and it retranslated into the native language by linguists. The questions, then, were validated through

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Tyson, Elisa K., Roger Smith, and Mark Read. "Evidence that Corticotropin-Releasing Hormone Modulates Myometrial Contractility during Human Pregnancy." Endocrinology 150, no. 12 (2009): 5617–25. http://dx.doi.org/10.1210/en.2009-0348.

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Abstract As human pregnancy advances, CRH increases exponentially and is hypothesized to trigger the transition from myometrial quiescence to active contractions at labor. Paradoxically, CRH stimulates cAMP production, suggesting it should cause relaxation. To evaluate CRH as a mediator of quiescence, the effect of CRH on contractions in preterm and term myometria with concurrent progesterone (P4) was determined. In late gestation, we hypothesized that high concentrations of CRH down-regulate agonist-activated-cAMP relaxatory pathways and that increased phosphodiesterase (PDE) activity induces

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Yamanaka, Yasuo, Hiroyuki Tagawa, Naoto Takahashi, et al. "Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer–cell lymphoma/leukemia." Blood 114, no. 15 (2009): 3265–75. http://dx.doi.org/10.1182/blood-2009-06-222794.

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Abstract The gene(s) responsible for natural killer (NK)–cell lymphoma/leukemia have not been identified. In the present study, we found that in NK-cell lymphoma lines (n = 10) and specimens of primary lymphoma (n = 10), levels of miR-21 and miR-155 expression were inversely related and were significantly greater than those found in normal natural killer (CD3−CD56+) cells (n = 8). To determine the functions of these microRNAs in lymphomagenesis, we examined the effects of antisense oligonucleotides (ASOs) targeting miR-21 (ASO-21) and/or miR-155 (ASO-155) in NK-cell lymphoma lines overexpressi

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Yan, Xu, Mei J. Zhu, Wei Xu та ін. "Up-Regulation of Toll-Like Receptor 4/Nuclear Factor-κB Signaling Is Associated with Enhanced Adipogenesis and Insulin Resistance in Fetal Skeletal Muscle of Obese Sheep at Late Gestation". Endocrinology 151, № 1 (2010): 380–87. http://dx.doi.org/10.1210/en.2009-0849.

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Abstract Maternal obesity is increasing at an alarming rate. We previously showed that maternal obesity induces an inflammatory response and enhances adipogenesis in fetal skeletal muscle at midgestation. The objective of this study was to evaluate effects of maternal obesity on adipogenesis, inflammatory signaling, and insulin pathways at late gestation when ovine fetal skeletal muscle matures. Nonpregnant ewes were assigned to a control diet (Con, fed 100% of National Research Council nutrient recommendations, n = 6) or obesogenic diet (OB, fed 150% of National Research Council recommendatio

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Dahl, Tuva B., John Willy Haukeland, Arne Yndestad, et al. "Intracellular Nicotinamide Phosphoribosyltransferase Protects against Hepatocyte Apoptosis and Is Down-Regulated in Nonalcoholic Fatty Liver Disease." Journal of Clinical Endocrinology & Metabolism 95, no. 6 (2010): 3039–47. http://dx.doi.org/10.1210/jc.2009-2148.

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Abstract Context: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western and non-Western countries, but its pathogenesis is not fully understood. Objective: Based on the role of nicotinamide phosphoribosyltransferase (NAMPT) in fat and glucose metabolism and cell survival, we hypothesized a role for NAMPT/visfatin in the pathogenesis of NAFLD-related disease. Design and Setting: We conducted clinical studies at a referral medical center in well-characterized NAFLD patients (n = 58) and healthy controls (n = 27). In addition we performed experimental in vitro studi

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Bao, Weili, Susanne Heck, Wu He, et al. "Altered Regulation of Immune Responses in Alloimmunized Chronically Transfused Patients with Sickle Cell Disease." Blood 114, no. 22 (2009): 637. http://dx.doi.org/10.1182/blood.v114.22.637.637.

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Abstract Abstract 637 Transfusion therapy is hampered by the development of alloantibodies to transfused red blood cells (RBCs). A recent mathematical model for RBC alloimmunization predicted that approximately 13% of the general population are antibody producers (responders) (Higgins and Sloan, 2008). However, immune molecular markers which may predict these transfusion responders have not been clearly demonstrated. We recently reported in a mouse model that key immune response regulators, CD4+ regulatory T cells (Tregs) have reduced activity in alloantibody responders compared to non-respond

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Haferlach, Claudia, Cristina Mecucci, Susanne Schnittger, et al. "AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features." Blood 114, no. 14 (2009): 3024–32. http://dx.doi.org/10.1182/blood-2009-01-197871.

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Acute myeloid leukemia (AML) with mutated NPM1 usually carries normal karyotype (NK), but it may harbor chromosomal aberrations whose significance remains unclear. We addressed this question in 631 AML patients with mutated/cytoplasmic NPM1. An abnormal karyotype (AK) was present in 93 of 631 cases (14.7%), the most frequent abnormalities being +8, +4, −Y, del(9q), +21. Chromosome aberrations in NPM1-mutated AML were similar to, but occurred less frequently than additional chromosome changes found in other AML with recurrent cytogenetic abnormalities according to WHO classification. Four of th

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Tran, M., C. Thompson, C. Walsh, S. McLeod, and B. Borgundvaag. "LO64: A systematic review of interventions to influence opioid prescribing from the emergency department." CJEM 22, S1 (2020): S30—S31. http://dx.doi.org/10.1017/cem.2020.119.

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Introduction: The opioid crisis has reached epidemic levels in Canada, driven in large part by prescription drug use. Emergency physicians are frequent prescribers of opioids; therefore, the emergency department (ED) represents an important setting for potential intervention to encourage rational and safe prescribing. The objective of this study was to systematically review the literature on interventions aimed to influence opioid prescribing in the ED. Methods: Electronic searches of Medline and Cochrane were conducted and reference lists were hand-searched. All quantitative studies published

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Finch, Ann R., Christopher J. Caunt, Stephen P. Armstrong, and Craig A. McArdle. "Plasma Membrane Expression of Gonadotropin-Releasing Hormone Receptors: Regulation by Peptide and Nonpeptide Antagonists." Molecular Endocrinology 24, no. 2 (2010): 423–35. http://dx.doi.org/10.1210/me.2009-0343.

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Abstract Gonadotropin-releasing hormone acts via cell surface receptors but most human (h) GnRH receptors (GnRHRs) are intracellular. A membrane-permeant nonpeptide antagonist [(2S)-2-[5-[2-(2-axabicyclo[2.2.2]oct-2-yl)-1,1-dimethy-2-oxoethyl]-2-(3,5-dimethylphenyl)-1H-indol-3-yl]-N-(2-pyridin-4-ylethyl)propan-1-amine (IN3)] increases hGnRHR expression at the surface, apparently by facilitating its exit from the endoplasmic reticulum. Here we have quantified GnRHR by automated imaging in HeLa cells transduced with adenovirus expressing hemagglutinin-tagged GnRHR. Consistent with an intracellul

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Hylton, Rebecca A., Peter C. Frederick, Teresa E. De La Fuente, and Marilyn G. Spalding. "Effects of Nestling Health on Postfledging Survival of Wood Storks." Condor 108, no. 1 (2006): 97–106. http://dx.doi.org/10.1093/condor/108.1.97.

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AbstractLittle is known about the period between fledging and breeding in long-lived birds, including survival rates and factors affecting survival, yet this period may be critical to population regulation. We conducted health exams on 72 nestling Wood Storks (Mycteria americana) aged 4–6 weeks, and monitored survival of these birds via satellite telemetry for up to two years of age. Eighty-two percent of nestlings fitted with transmitters in 2002 (n = 33) survived to fledging. Of these fledglings (n = 27), 44% survived their first year. Second-year survival for the same cohort (n = 12) was 75

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Buchheiser, Anja, Stefanie Liedtke, Amelie Pia Houben, et al. "Cord Blood as a Very Valuable Source of Neonatal Cells but Embryonic-Like Nature Reevaluated." Blood 112, no. 11 (2008): 2897. http://dx.doi.org/10.1182/blood.v112.11.2897.2897.

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Abstract Human umbilical cord blood has become a very valuable source for hematopoietic transplantation. Our group was able to show that CB contains non-hematopoietic stem cells, which were called unrestricted somatic stem cells (USSCs) with a multipotent differentiation potential. These cells have the potential to differentiate into different germ layers (Kögler et al. 2004, Kögler et al. 2005, Kögler et al. 2006, Sensken et al. 2007, Greschat et al. 2008, Ghodsizad A et al. 2008, Trapp et al. 2008). Some studies have now reported a presumably embryonic like nature of cord blood cells. How

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Gill, J., N. S. Shariff, K. M. Omar, A. H. M. Din, and Z. M. Amin. "A REVIEW ON LEGAL TRACEABILITY OF GNSS MEASUREMENTS IN THE MALAYSIAN CADASTRAL PRACTICE." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-4/W1 (September 29, 2016): 191–97. http://dx.doi.org/10.5194/isprs-archives-xlii-4-w1-191-2016.

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As the dependency on Global Navigation Satellite System (GNSS) in surveying has been growing over the years, the need for legal traceability of GNSS measurements has become a significant matter. In Malaysia, with the advent of the Malaysia Real-time Kinematic Network (MyRTKnet), GNSS surveying has revolutionised land survey and mapping. Correspondingly, the Department of Survey and Mapping Malaysia (DSMM) amended and published standard regulations and guidelines concerning cadastral survey, i.e., Cadastral Survey Regulations 2009, to include GNSS measurements. However, these regulations and gu

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Andayani, Friska Tri, and Endang Ekowarni. "Peran Relasi Orang Tua-Anak dan Tekanan Teman Sebaya terhadap Kecenderungan Perilaku Pengambilan Risiko." Gadjah Mada Journal of Psychology (GamaJoP) 2, no. 2 (2018): 138. http://dx.doi.org/10.22146/gamajop.33097.

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Alsa, A. (2014). Pendekatan kualitatif dan kuantitatif serta kombinasinya dalam penelitian psikologi. Cetakan V. Yogyakarta: Pustaka Pelajar.Badan Koordinasi Keluraga Berencana Nasional (BKKBN). (2011). Kajian profil penduduk remaja (10-24 tahun): Ada apa dengan remaja. Policy Brief Puslitbang Kependudukan. Retrieved fromhttp://www.depkes.go.id/resources/download/pusdatin/infodatin/infodatin%20reproduksi%20remaja-ed.pdfBadan Pusat Statistik (BPS). (2012). Survei demografi dan kesehatan Indonesia 2012. Kesehatan Reproduksi remaja. Jakarta: Kementerian Kesehatan Jakarta. Retrieved from http://ww

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Liao, Wu-xiang, Lin Feng, Jing Zheng, and Dong-bao Chen. "Deciphering Mechanisms Controlling Placental Artery Endothelial Cell Migration Stimulated by Vascular Endothelial Growth Factor." Endocrinology 151, no. 7 (2010): 3432–44. http://dx.doi.org/10.1210/en.2009-1305.

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Vascular endothelial growth factor (VEGF) stimulated fetoplacental artery endothelial (oFPAE) cell migration and activated multiple signaling pathways including ERK2/1, p38MAPK, Jun N-terminal kinase (JNK1/2), v-Akt murine thymoma viral oncogene homolog 1 (Akt1), and c-Src in oFPAE cells. VEGF-induced cell migration was blocked by specific kinase inhibitors of JNK1/2 (SP600125), c-Src (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d] pyrimidine), and phosphatidylinositol 3-kinase/Akt (wortmannin) but not ERK2/1 (U0126) and p38MAPK (SB203580). VEGF-induced cell migration was associated wit

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Pavlík, M., D. Pavlíková, J. Balík, and M. Neuberg. "The contents of amino acids and sterols in maize plants growing under different nitrogen conditions." Plant, Soil and Environment 56, No. 3 (2010): 125–32. http://dx.doi.org/10.17221/214/2009-pse.

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The effect of nitrogen nutrition on phytosterol and amino acid content in aboveground biomass of maize (<I>Zea mays</I> L.) was investigated in a pot experiment. For cultivation of maize plants nitrogen dose (2 or 4 g N/pot) was applied in the form of ammonium nitrate (AN) for control treatments or urea ammonium nitrate solution (UAN). UAN solution was applied according to the CULTAN method (Controlled Uptake Long Term Ammonium Nutrition). The content of amino acids as important nitrogen-containing compounds in plant biomass was affected by nitrogen nutrition. An increase of glutam

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Malykh, Olga. "Assessment, monitoring, and regulation of odors of any origin in industrial enterprises." Okhrana truda i tekhnika bezopasnosti na promyshlennykh predpriyatiyakh (Labor protection and safety procedure at the industrial enterprises), no. 8 (July 31, 2020): 74–79. http://dx.doi.org/10.33920/pro-4-2008-07.

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Virtually any enterprise in the food and chemical industries, as well as in treatment facilities, has waste with a distinctive unpleasant smell. Elimination of odors is becoming an urgent task for ensuring safety and labor protection at enterprises, as well as public health protection. Olga Malykh, junior research associate at the company "Odor Laboratory N 1", speaks about the experience of smell research at enterprises, the possibilities of olfactometric research, and modern methods and equipment.

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Coon, Steven L., Elena del Olmo, W. Scott Young, and David C. Klein. "Melatonin Synthesis Enzymes in Macaca mulatta: Focus on Arylalkylamine N-Acetyltransferase (EC 2.3.1.87)." Journal of Clinical Endocrinology & Metabolism 87, no. 10 (2002): 4699–706. http://dx.doi.org/10.1210/jc.2002-020683.

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Arylalkylamine N-acetyltransferase (AANAT; serotonin N-acetyltransferase, EC 2.3.1.87) plays a unique transduction role in vertebrate physiology as the key interface between melatonin production and regulatory mechanisms. Circulating melatonin is elevated at night in all vertebrates, because AANAT activity increases in the pineal gland in response to signals from the circadian clock. Circadian regulation of melatonin synthesis is implicated in a variety of human problems, including jet lag, shift work, insomnia, and abnormal activity rhythms in blind persons. In this report AANAT was studied i

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Shalaby, Ahmed, Timo Rinne, Otso Järvinen, et al. "The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2." Cardiology Research and Practice 2009 (2009): 1–6. http://dx.doi.org/10.4061/2009/658965.

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Background. We studied the effect of fast induction of cardiac arrest with denosine on myocardial bax and bcl-2 expression.Methods and Results. 40 elective CABG patients were allocated into two groups. The adenosine group (n=20) received 250 μg/kg adenosine into the aortic root followed by blood potassium cardioplegia. The control group received potassium cardioplegia in blood. Bcl-2 and bax were measured. Bax was reduced in the postoperative biopsies (1.38 versus 0.47,P=.002) in the control group. Bcl-2 showed a reducing tendency (0.14 versus 0.085,P=.07). After the adenosine treatment, the e

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Mtango, N., and K. Latham. "190 CELL CYCLE REGULATION IN RHESUS MONKEY OOCYTES AND EMBRYOS OF DIFFERENT DEVELOPMENTAL POTENTIAL." Reproduction, Fertility and Development 21, no. 1 (2009): 194. http://dx.doi.org/10.1071/rdv21n1ab190.

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After fertilization, cell division is required for development during the transition from a zygote to an embryo. Degradation of oocyte transcripts, transcriptional activation of the nucleus, and chromatin remodeling occur during early cleavage divisions. Defects in cell cycle regulation decrease the ability of embryo to grow and can be detrimental. In the rhesus monkey, embryos derived by fertilization of oocytes from prepubertal females or oocytes collected during the non-breeding season undergo cleavage arrest (Schramm and Bavister 1994; Zheng et al. 2001). We employed the Primate Embryo Gen

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Lee, Sunghou, Hong Ji, Zheng Wu, Wei Zheng, Ali Hassan, and Kathryn Sandberg. "Translational regulation of ANG II type 1 receptors in proliferating vascular smooth muscle cells." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 290, no. 1 (2006): R50—R56. http://dx.doi.org/10.1152/ajpregu.00448.2005.

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The current study examined angiotensin receptor (ATR) regulation in proliferating rat aortic vascular smooth muscle cells (VSMCs) in culture. Radioligand competition analysis coupled with RNase protection assays (RPAs) revealed that angiotensin type 1a receptor (AT1aR) densities (Bmax) increased by 30% between 5 and 7 days in culture [Bmax (fmol/mg protein): day 5, 379 ± 8.4 vs. day 7, 481 ± 12, n = 3, P < 0.05] under conditions in which no significant changes in AT1aR mRNA expression occurred [in RPA arbitrary units (AU): day 5, 0.23 ± 0.01 vs. day 7, 0.24 ± 0.04, n = 4] or in mRNA synthes

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Lei, Hong Jun, Chang Jia Li, Xun Feng Xia, and Bei Dou Xi. "Decomposing the Influencing Factors of China’s Industrial Wastewater Discharges Using LMDI I Method." Advanced Materials Research 518-523 (May 2012): 2089–98. http://dx.doi.org/10.4028/www.scientific.net/amr.518-523.2089.

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China’s industry accounts for 46.8% of the national gross domestic product (GDP) and plays an important strategic role to its economic growth, but it is also the main water pollution sources. In order to identify the relationship between the underlying driving forces and various environmental indicators, two critical industrial wastewater pollutant discharges over 2001-2009, including Chemical Oxygen Demand (COD) and ammonia nitrogen (NH4-N), were decomposed into three factors, i.e., production effect (caused by change in the scale of economic activity), structural effect (caused by change in

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Peyron-Caso, E., S. Fluteau-Nadler, M. Kabir, et al. "Regulation of Glucose Transport and Transporter 4 (GLUT-4) in Muscle and Adipocytes of Sucrose-Fed Rats: Effects of N-3 Poly- and Monounsaturated Fatty Acids." Hormone and Metabolic Research 34, no. 7 (2002): 360–66. http://dx.doi.org/10.1055/s-2002-33467.

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Zhang, Qi, Valta Collins, Kaushik Chakrabarty, et al. "Regulation of Membrane-Associated Prostaglandin E2 Synthase 1 in Pregnant Sheep Intrauterine Tissues by Glucocorticoid and Estradiol." Endocrinology 147, no. 8 (2006): 3719–26. http://dx.doi.org/10.1210/en.2006-0293.

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This study was designed to determine the regulatory effect of glucocorticoid and estradiol on expression of ovine intrauterine membrane-associated prostaglandin E2 synthase 1 (mPTGES1) in late gestation and at labor. For gestational and labor groups, 16 pregnant ewes from 95–147 d gestational age (dGA) and four pregnant ewes at spontaneous term labor were used. The fetal glucocorticoid group, 14 pregnant ewes at 123–125 dGA with fetuses, was divided into the following groups: after sham adrenalectomy (n = 5), adrenalectomy (n = 4), and adrenalectomy with fetal cortisol replacement to late gest

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Barreyro, Gladys Beatriz. "Novas regulações na educação superior: do Estado Avaliador à acreditação em escala global (New regulations in higher education: from the Evaluative State to accreditation at the global scale)." Revista Eletrônica de Educação 13, no. 3 (2019): 837. http://dx.doi.org/10.14244/198271993530.

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The text analyzes the transformation of the accreditation/evaluation) of higher education from a policy of the Evaluative State, in the ´80s, to a global policy with different modalities. Based on the concepts developed by Susan Robertson and Roger Dale in relation to the multi-scalar governance of higher education, it is shown the existence of accreditation policies at different scales, as well as the participation of different institutions and actors (international, private and non profit). The impact of the General Agreement on Trade and Services (GATS) in higher education, and specifically

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Lien, Chih-Chan, Lo-Chun Au, Ying-Lan Tsai, Low-Tone Ho та Chi-Chang Juan. "Short-Term Regulation of Tumor Necrosis Factor-α-Induced Lipolysis in 3T3-L1 Adipocytes Is Mediated through the Inducible Nitric Oxide Synthase/Nitric Oxide-Dependent Pathway". Endocrinology 150, № 11 (2009): 4892–900. http://dx.doi.org/10.1210/en.2009-0403.

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TNF-α has several effects on adipocytes that may be related to the development of type 2 diabetes in obese subjects. Many studies demonstrated that long-term treatment with TNF-α increases lipolysis in adipocytes. However, the short-term (&lt;4 h) effects of TNF-α on lipolysis have not been well investigated. The aim of this study was to investigate the short-term regulatory mechanism of TNF-α-induced lipolysis in 3T3-L1 adipocytes. Well-differentiated 3T3-L1 adipocytes were used. Lipolysis was determined by measuring glycerol release. Expression of inducible nitric oxide (iNOS) and nitric

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Vlotides, George, Yen-Hao Chen, Tamar Eigler, Song-Guang Ren, and Shlomo Melmed. "Fibroblast Growth Factor-2 Autofeedback Regulation in Pituitary Folliculostellate TtT/GF Cells." Endocrinology 150, no. 7 (2009): 3252–58. http://dx.doi.org/10.1210/en.2008-1625.

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To investigate paracrine regulation of pituitary cell growth, we tested fibroblast growth factor (FGF) regulation of TtT/GF folliculostellate (FS) cells. FGF-2, and FGF-4 markedly induced cell proliferation, evidenced by induction of pituitary tumor transforming gene-1 (Pttg1) mRNA expression and percentage of cells in S phase. Signaling for FGF-2-induced FS cell proliferation was explored by specific pharmacological inhibition. A potent inhibitory effect on FGF-2 action was observed by blocking of Src tyrosine kinase with 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d] pyrimidine (≥0.1

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Călinici, Mirela Simona, Tudor Călinici, Robert Balaszi, and Mircea Miclea. "Development and validation of a new ability-based measure of emotional intelligence: Cluj Emotional Intelligence Scale CEIS." Cognition, Brain, Behavior. An interdisciplinary journal 24, no. 4 (2020): 335–63. http://dx.doi.org/10.24193/cbb.2020.24.18.

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Theoretical models of ability-based emotional intelligence (EI) present the ability to regulate other’s emotion as part of the emotion regulation facet, but in existing ability-based self-report EI measures, this ability is often not evaluated (e.g., Wong and Law Emotional Intelligence Scale, WLEIS, 2004) or is evaluated as a separate facet, in the work context (e.g., Workgroup Emotional Intelligence Profile WEIP-3, 2002). This consideration led to the development of a new self-report EI measure to assess EI abilities (Cluj Emotional Intelligence Scale, CEIS); the process of development and va

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Cooper, Maria, Lauren R. Pacek, Mignonne C. Guy, et al. "Hookah Use Among US Youth: A Systematic Review of the Literature From 2009 to 2017." Nicotine & Tobacco Research 21, no. 12 (2018): 1590–99. http://dx.doi.org/10.1093/ntr/nty135.

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Abstract Introduction Given the US Food and Drug Administration (FDA)’s authority to regulate hookah, more research is needed to inform regulations intended to prevent youth from using hookah. This systematic review summarizes and assesses the literature related to hookah use among adolescents (11 to ≤18 years of age) in the United States from 2009 to 2017. Methods Database searches yielded 867 peer-reviewed articles. After duplicates were removed, authors reviewed 461 articles for inclusion. Included articles (n = 55) were coded for study themes, study quality, and their relevance to FDA’s re

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Savchenko, Olena. "Psychosemantic Tools of Self-Assessing Individual Reflectivity." East European Journal of Psycholinguistics 6, no. 2 (2019): 98–106. http://dx.doi.org/10.29038/eejpl.2019.6.2.sav.

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In this article, reflectivity is considered as an individual general ability to develop different attitudes to life events in order to reduce an external and internal uncertainty in situations. The objective of the research is to examine the self-assessment criteria for reflectivity with psychosemantic procedure. The author designs a modified version of the Ch. Osgood’s (1957) Semantic Differential (SD) for examining the content and formal features of the self-assessment criteria of reflectivity. This study suggests two main processes of self-assessment of reflectivity, notably differentiation

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Picard, B., B. Meunier, Y. Heyman, P. Chavatte-Palmer, and I. Cassar-Malek. "74 PROTEOMIC PROFILING DURING FETAL DEVELOPMENT OF BOVINE CLONES." Reproduction, Fertility and Development 22, no. 1 (2010): 195. http://dx.doi.org/10.1071/rdv22n1ab74.

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Previous data have shown that bovine clones display a delay in their muscle differentiation during their first year postnatal (Jurie et al. 2009 Animal 2, 244-250). This delay could originate from perturbations in fetal muscle development as illustrated by lower numbers and degree of organization of the first generation of myotubes at 60 dpc and by their lower energy metabolism and their myosin heavy chain pattern at 260 dpc (Cassar-Malek et al. 2009 Proc. XIth ISRP abst). In order to understand the mechanisms underlying the delay in myogenesis, we have performed a comparative proteomic analys

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Giver, Cynthia R., Zahir Ali, Sheilagh Barclay, et al. "Allogeneic HSCT Patients Receiving More RBC Transfusions Are At Increased Risk For Development Of Grade 2-4 Acute Graft-Versus-Host Disease." Blood 122, no. 21 (2013): 3298. http://dx.doi.org/10.1182/blood.v122.21.3298.3298.

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Abstract Background A critical barrier to progress in allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been a lack in understanding regarding why some transplant recipients of HLA-matched transplant grafts develop severe graft-versus-host disease (GvHD) while other recipients have relapse of their cancer without GvHD. Patients who develop a modest degree of acute and/or chronic GvHD have less relapse and optimal survival after allogeneic BMT. Thus, a mechanistic understanding of regulation of donor T-cell activation after allo-HSCT is needed. Using mouse models, Desmarets et

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Mraz, Marek, Karla Malinova, Sarka Pavlova, et al. "Detail Characterization of 22q11 Deletion and Mir-650 Role in CLL Patients." Blood 114, no. 22 (2009): 1231. http://dx.doi.org/10.1182/blood.v114.22.1231.1231.

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Abstract Abstract 1231 Poster Board I-253 Background Chromosomal abnormalities are present in the majority of CLL cases (&gt;80%) and recently, a novel deletion of 22q11 was described in CLL patients. This locus encodes lambda immunoglobulin light chain (IgL) subgenes and several protein-coding genes, which distinguishes IgL from kappa Ig or heavy Ig locus. Gunn et al. (2008) previously characterized the minimally deleted region of 22q11 in CLL as 0,34Mb (containing PRAME, ZNF280A, ZNF280B, GGTLC2) and described the PRAME as a candidate gene with prognostic impact in CLL. Interestingly, th

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Barsukov, A. V., O. G. Chepcheruk, D. V. Glukhovskoi, A. E. Korovin, V. V. Yakovlev, and A. V. Gordienko. "Baroreflex circulation regulation during tilt test in young males with a history of vasovagal syncopes." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 25, no. 2 (2019): 158–68. http://dx.doi.org/10.18705/1607-419x-2019-25-2-158-168.

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Background. Vasovagal syncopes (VVS) are relatively often recorded in the population of young people. Objective. To establish the changes in the baroreflex function during the tilt test in healthy young males with the history of VVS. Design and methods. A total of 102 people aged 18–30 years were examined and divided into 4 groups, taking into account the specific features of fainting history and response to the tilt test. Subjects of the group 1 (n = 14) had a history of VVS and a positive response to the tilt test (syncope). Subjects of the group 2 (n = 14) had a history of VVS and a pattern

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Dinkins, Jonathan B., Kirstie J. Lawson, and Jeffrey L. Beck. "Influence of environmental change, harvest exposure, and human disturbance on population trends of greater sage-grouse." PLOS ONE 16, no. 9 (2021): e0257198. http://dx.doi.org/10.1371/journal.pone.0257198.

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Hunter harvest of greater sage-grouse (Centrocercus urophasianus; hereafter “sage-grouse”) has been regulated by wildlife agencies during most of the past century. Hunting season regulations were maintained with the intention of providing sustainable hunting opportunities. Sage-grouse populations oscillate over time, and population growth can be influenced by seasonal weather and habitat disturbance. From 1995–2013, we compared sage-grouse lek trends from 22 relatively distinct sage-grouse population segments in 9 western U.S. states and 2 Canadian provinces. We stratified these populations in

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Marselina, Mariana, and Muhamad Burhanudin. "Trophic Status Assessment of Saguling Reservoir, Upper Citarum Basin, Indonesia." Air, Soil and Water Research 10 (January 1, 2017): 117862211774666. http://dx.doi.org/10.1177/1178622117746660.

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This study examined the water quality of Saguling Reservoir as potential raw water for Bandung metropolitan area. Determination of water quality in this study consisted of trophic status determination based on total phosphorus, total nitrogen (ammonia and nitrate), and water clarity. Data were obtained 4 times a year for 16 years (1999-2013). We determined the overall water quality status by comparing data with criteria specified in Ministerial Regulation (Permen) of the Environment Number 28 of 2009 on the Water Pollution Load Capacity of Lakes or Reservoirs. Data from 11 stations were analyz

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Battula, Venkata Lokesh, Phuong M. Le, Jeffrey Sun, et al. "Acute Myeloid Leukemia Cells Acquire Chemo-Resistance By Inducing Osteoblast Differentiation in Mesenchymal Stem Cells through up-Regulation of RUNX2." Blood 124, no. 21 (2014): 2929. http://dx.doi.org/10.1182/blood.v124.21.2929.2929.

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Abstract The leukemia bone marrow micro-environment (BME) is comprised of the endosteal and vascular niches, provides vital support for cellular growth and conveys drug resistance to leukemia cells. Several reports suggest that mesenchymal stem/stromal cells (MSCs) present in the bone marrow niche induce cell survival and anti-apoptotic proteins in acute myeloid leukemia (AML) cells and protect them from chemotherapy. The mechanisms underlying BME-mediated chemo-resistance however have not been fully elucidated. Here, we hypothesize that AML cells induce functional changes and prime MSCs to pr

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Cohen, Adam D., Indira D. Joshi, Valentin Robu, et al. "Assessing CD137 (4-1BB) As a Therapeutic Target in B-Cell Neoplasms,." Blood 118, no. 21 (2011): 3735. http://dx.doi.org/10.1182/blood.v118.21.3735.3735.

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Abstract Abstract 3735 Agonist monoclonal antibodies (mAbs) to CD137, a co-stimulatory TNF receptor family member expressed on activated T and NK cells, can induce immune-mediated rejection of multiple murine tumor types, and a fully human anti-CD137 mAb, BMS-663513, is in early-phase clinical trials in solid tumors. Significant activity has been seen in murine lymphoma models, both alone and in combination with anti-CD20 mAbs, providing rationale for clinical studies in lymphoma patients. Recently, however, CD137 up-regulation on activated human B cells has been reported, with CD137 ligation

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Fu, Dong, and Des R. Richardson. "Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion." Blood 110, no. 2 (2007): 752–61. http://dx.doi.org/10.1182/blood-2007-03-076737.

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Abstract Iron (Fe) plays a critical role in proliferation, and Fe deficiency results in G1/S arrest and apoptosis. However, the precise role of Fe in cell-cycle control remains unclear. We observed that Fe depletion increased the mRNA of the universal cyclin-dependent kinase inhibitor, p21CIP1/WAF1, while its protein level was not elevated. This observation is unique to the G1/S arrest seen after Fe deprivation, as increased p21CIP1/WAF1 mRNA and protein are usually found when arrest is induced by other stimuli. In this study, we examined the posttranscriptional regulation of p21CIP1/WAF1 afte

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Bourgne, Céline, Alexandre Janel, Juliette Berger, et al. "Dramatic Down-Regulation Of MNDA Expression In CP-CML Cells From The LSC Compartment." Blood 122, no. 21 (2013): 2717. http://dx.doi.org/10.1182/blood.v122.21.2717.2717.

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Abstract Introduction Chronic Phase - Chronic Myeloid Leukemia (CP-CML) is a myeloproliferative disorder characterized by malignant proliferation of the granulocytic lineage without the arrest of cell differentiation. Tyrosine Kinase Inhibitors (TKI) have revolutionized CML treatment but several studies showed that a combination of TKI and Interferon alpha (IFNα) provides better clinical response. Myeloid Nuclear Differentiation Antigen (MNDA), which belongs to the hematopoietic interferon-inducible nuclear proteins with the 200-amino-acid repeat (HIN200) gene family, encodes a protein express

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Polkowska, Agnieszka, Izabela Elżbieta Pasierowska, Marta Pasławska, Elżbieta Pawluczuk, and Artur Bossowski. "Assessment of Serum Concentrations of Adropin, Afamin, and Neudesin in Children with Type 1 Diabetes." BioMed Research International 2019 (October 24, 2019): 1–6. http://dx.doi.org/10.1155/2019/6128410.

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Introduction. The increasing knowledge of adropin, afamin, and neudesin and the regulation of glucose metabolism and insulin resistance allows for the assessment of the differences in their concentrations between the groups with varied duration of diabetes mellitus (DM). Aim of the Study. Assessment of serum levels of adropin, afamin, and neudesin in children with type 1 diabetes, with respect to the disease duration. Materials and Methods. The study consisted of 138 patients aged 5–18 years (M 40.58%). Children with type 1 diabetes (n = 68) were compared to the control group (n = 70). The dia

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McCormick, Stanley R., Craig W. S. Howe, Pierre Brousset, et al. "Myeloproliferative Neoplasm Resembling Polycythemia Vera In a Patient with t(2;11)(p21;q23) Translocation and Persistently Elevated MiR-125b-1." Blood 116, no. 21 (2010): 5067. http://dx.doi.org/10.1182/blood.v116.21.5067.5067.

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Abstract Abstract 5067 Background: Hematologic neoplasms associated with the chromosomal translocation t(2;11)(p21;q23) form a distinct genetic entity with diverse manifestations, and have been strongly linked with up-regulation of the microRNA miR-125b-1 (Bousquet et al, J Exp Med, 2008). Of 41 patients with myeloid malignancies and t(2;11)(p21;23) reported in the world's literature, all but 2 were cases of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), the latter cases frequently high-grade MDS transforming to AML. In 20 of 41 cases deletion of 5q was detected as a secondary

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Geißler, Carmen, Christopher Schulze, Sebastian Botzenhardt, Wolfgang Rascher, and Antje Neubert. "Drug Utilisation and Off-Label Use on a German Neonatal Intensive Care Unit: A Retrospective Cohort Study and 10-Year Comparison." Pharmacy 8, no. 3 (2020): 173. http://dx.doi.org/10.3390/pharmacy8030173.

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Pharmacotherapy of neonates is complex and marked to a large extent of off-label use. The implementation of the Paediatric Regulation (2007) gave hope for a change in the safety and efficacy for drugs used in neonatal intensive care units (NICU). This study investigates drug utilisation patterns and off-label use in a German neonatal intensive care unit (NICU) in 2014. A 12-months retrospective, observational cohort study was performed at the NICU of the University Children’s Hospital Erlangen, Germany. Licensing status was determined using the Summary of Product Characteristics (SmPC). Result

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Day, Nancy S., Janet Ayello, Ian Waxman, et al. "Comparative Genomic Identification of Unique Signal Transduction Pathways and Targets In Pediatric Burkitt Lymphoma (PBL)." Blood 116, no. 21 (2010): 631. http://dx.doi.org/10.1182/blood.v116.21.631.631.

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Abstract Abstract 631 Background: The prognosis of PBL has dramatically improved over the past 25 years (> 80% 5 yrs EFS) (Cairo et al BJH 2009). This success, however, has come at the cost of the high toxicity associated with intensive multi-agent chemotherapy. A need to identify less toxic targeted therapy exists. Our recent studies show that while almost 100% of childhood BL (238 children) is characterized by an 8q24 (c-myc) gene rearrangement, 70% of the patients also had a secondary chromosomal aberration (Cairo et al Blood 2007), and those children with BL who had a 13q abnormality ha

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Darlington, Daniel N., Xiaowu Wu, Kevin L. Chang, James Bynum, and Andrew P. Cap. "Regulation of Platelet Function By Adenosine Receptors." Blood 134, Supplement_1 (2019): 2348. http://dx.doi.org/10.1182/blood-2019-131129.

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Introduction: We have recently shown that severe trauma and hemorrhage lead to inhibition of platelet aggregation and an elevation in cyclic adenosine monophosphate (cAMP). Adenosine is one of the few humoral agents known to stimulate cAMP in platelets. Because adenosine is released from damaged tissue, it may contribute to the platelet dysfunction seen after severe trauma. Platelets have four adenosine receptors (A1, A2a, A2b and A3). These receptors are G-Protein Coupled Receptors and have been proposed to stimulate adenylyl cyclase and increase intracellular cAMP. Although studies have show

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Rajaraman, G., P. Murthi, S. P. Brennecke, and B. Kalionis. "220. Homeobox gene HLX is a regulator of HGF/c-met mediated trophoblast migration." Reproduction, Fertility and Development 20, no. 9 (2008): 20. http://dx.doi.org/10.1071/srb08abs220.

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Homeobox gene transcription factors play critical roles in normal placental development and are expressed in specialised trophoblast cells. Abnormal trophoblast cell function is associated with pregnancy disorders including fetal growth restriction. Our studies show homeobox gene HLX expression in trophoblast cells (1) and that HLX is significantly decreased in fetal growth restriction (2). HLX gene inactivation in cultured trophoblast cells shows that HLX is a regulator of cytokine-dependent trophoblast proliferation (3). Hepatocyte growth factor (HGF) activates trophoblast cell migration in

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Wellbrock, Jasmin, Eik Vettorazzi, Gabi Vohwinkel, et al. "Expression of Roundabout Receptor 4 (Robo-4) Confers a Negative Prognosis On Patients with Acute Myeloid Leukemia." Blood 120, no. 21 (2012): 1412. http://dx.doi.org/10.1182/blood.v120.21.1412.1412.

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Abstract Abstract 1412 Background: Roundabout receptors – predominantly Robo-1 and Robo-4 – have been described as endothelial-specific markers which may be involved in the establishment of tumor neoangiogenesis. Since hematopoietic and endothelial cells are derived from a common precursor, the hemangioblast, they share many surface antigens such as CD34 or receptors for vascular endothelial growth factor. In this regard, expression of Robo-4 has been demonstrated on hematopoietic stem cells (HSC). It may serve here in cooperation with CXCR4 as an anchor for HSCs within the stem cell niche (Sm

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Ruiz, Maria Armila, Kestis Vaitkus, Aparna Vasanthakumar та ін. "Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation". Blood 120, № 21 (2012): 824. http://dx.doi.org/10.1182/blood.v120.21.824.824.

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Abstract Abstract 824 DNA methylation is a key element responsible for γ-globin gene repression in adult erythroid cells. Our laboratory previously observed that the γ-globin gene promoter region was demethylated in a progressive manner as γ-globin expression was activated during erythroid differentiation of primary baboon pre-switch fetal liver cells and, to a lesser extent, of adult baboon bone marrow (BM) cells (Singh et al Exp Hematol 35:48-55, 2007). The mechanism responsible for DNA demethylation of the γ-globin promoter during erythroid differentiation remains unknown. Recent studies ha

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Nagano, Masumi, Ken-ichi Kimura, Toshiharu Yamashita, et al. "A Chemokine Receptor CXCR4 Plays a Crucial Role for Repairing Ischemic Tissue through Regulation of HIF-2a." Blood 112, no. 11 (2008): 3923. http://dx.doi.org/10.1182/blood.v112.11.3923.3923.

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Abstract Endothelial progenitor cells (EPCs) are potential therapeutic tools for treatment of ischemic tissues. We previously divided EPCs into two populations on the basis of aldehyde dehydrogenase (ALDH) activities and demonstrated that EPCs with low ALDH activity (Alde-Low EPCs) possess a greater ability for repairing ischemic tissue than those with high ALDH activity by using mouse dorsal skin flap model (Nagano et al., Blood, 2007). To explore molecular basis of the function of Alde-Low EPCs, we transduced small interfering RNAs (siRNAs) into Alde-Low EPCs to reduce the expression of hypo

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Slone, Stephen P., Donald R. Fleming, and John J. Buchino. "Sinus Histiocytosis With Massive Lymphadenopathy and Langerhans Cell Histiocytosis Express the Cellular Adhesion Molecule CD31." Archives of Pathology & Laboratory Medicine 127, no. 3 (2003): 341–44. http://dx.doi.org/10.5858/2003-127-0341-shwmla.

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Abstract Context.—We investigated expression of the adhesion molecule CD31 in sinus histiocytosis with massive lymphadenopathy (SHML) and Langerhans cell histiocytosis (LCH) because (1) SHML and LCH cells express a variety of cellular adhesion molecules and (2) SHML has been characterized as a reactive histiocytic proliferation, and tissue macrophages (histiocytes) are known to express CD31. Objective.—The purpose of this study was to determine whether SHML and LCH cells express CD31 and whether dual staining with CD31 and S100 facilitates diagnosis of these disease states. Methods.—Formalin-f

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