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Dissertations / Theses on the topic 'Regulation of Cdc42'

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Published: 25 May 2024

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1

Ravichandran, Yamini. "Cdc42 isoforms : localization, functions and regulation." Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS405.

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Les mutations sont responsables de diverses pathologies du développement, en particulier chez les patients atteints de maladies rares ou pour lesquels il n’y a pas de diagnostic clinique clair. Cdc42 est une protéine clé pour la polarité cellulaire, une étape cruciale de nombreux processus cellulaires, comme la migration cellulaire, la division cellulaire ou la réponse immunitaire. Les mutations de Cdc42 entrainent une variété de pathologies, par exemple des dérégulations de la croissance ou de la morphologie faciale ainsi que des anomalies immunologiques, hématologiques et du développement ne

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2

Lu, Ruifeng, and Jean M. Wilson. "Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42." NATURE PUBLISHING GROUP, 2016. http://hdl.handle.net/10150/622499.

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The generation of cell polarity is essential for the development of multi-cellular organisms as well as for the function of epithelial organs in the mature animal. Small GTPases regulate the establishment and maintenance of polarity through effects on cytoskeleton, membrane trafficking, and signaling. Using short-term 3-dimensional culture of MDCK cells, we find that the small GTPase Rab14 is required for apical membrane specification. Rab14 knockdown results in disruption of polarized lipid domains and failure of the Par/aPKC/Cdc42 polarity complex to localize to the apical membrane. These ef

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3

Murali, Arun [Verfasser]. "Role of XIAP in ubiquitin mediated regulation of Cdc42 and other Rho GTPases / Arun Murali." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1191286649/34.

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4

Francis, Monika K. "Regulation of GRAF1 membrane sculpting function during cell movement." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111213.

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All eukaryotic cells rely on endocytic events to satisfy a constant need for nutrient and fluid uptake from their surroundings. Endocytosis-dependent turnover of cell surface constituents also serves to control signal transduction and establish morphological changes in response to extracellular stimuli. During endocytosis, distinct protein machineries re-sculpt the plasma membrane into vesicular carriers that enclose molecules that are to be taken up into the cell. Besides those produced from the canonical clathrin-mediated endocytic machinery, it is becoming increasingly clear that other memb

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5

Mutavchiev, Delyan Rumenov. "Regulation of fission yeast cell polarity by stress-response pathways." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29006.

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Cell polarisation is a key biological process crucial for the functioning of essentially all cells. Regulation of cell polarity is achieved through various processes determined by both internal and external factors. An example of the latter is that cell polarity can be disrupted or lost as a consequence of a variety of external stresses. When facing such stresses, cells adapt to unfavourable conditions by activating a range of molecular signalling pathways, collectively termed ‘stress response’. Despite the connections between external stress and cell polarity, whether stress-response signalli

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6

Langer, Torben [Verfasser]. "Der Einfluss des Tumorsuppressorproteins Merlin auf die Regulation der beiden Rho-GTPasen Rac2 und Cdc42 / Torben Langer." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1036215121/34.

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7

Ye, Xiangcang. "Role of a CDC42 homologous gene in the regulation of cell polarity and morphogenic transitions in Wangiella dermatitidis /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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8

Primeau, Martin. "Novel mechanisms of regulation of the Cdc42 GTPase- activating protein CdGAP/ARHGAP31, a protein involved in cell migration and adhesion." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96901.

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The Rho GTPases form a family of enzymes that control numerous cellular processes including cell migration and proliferation through effects on the cytoskeleton, membrane trafficking and cell adhesion. The activity of these molecular switches is modulated by GTPase-activating proteins (GAPs), a group of negative-regulators which includes Cdc42-GTPase-Activating Protein (CdGAP). This protein specifically negatively-regulates the Rho GTPases Cdc42 and Rac1. In this study, we show that CdGAP is regulated by lipid-, protein- and intramolecular-interactions. First, we demonstrate that a polybasic r

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9

Ofo, Enyinnaya. "Flourescent biosensor-based, Cdc42 activity imaging for understanding the regulation of Epidermal Growth Receptor (EGFR) signalling in head and neck cancer." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/flourescent-biosensorbased-cdc42-activity-imaging-for-understanding-the-regulation-of-epidermal-growth-receptor-egfr-signalling-in-head-and-neck-cancer(32081fef-10f1-4a3e-ac33-67afbbf78376).html.

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The Epidermal Growth Factor Receptor (EGFR) is overexpressed in several solid tumours including squamous cell carcinoma of the head & neck (SCCHN). Drugs that directly block the action of EGFR are currently available. However, a major unanswered question is; how best to select patients most likely to respond to these new treatments, as the response rate to EGFR-targeted mono-therapy in SCCHN, as well as other solid tumours, such as lung and colorectal cancer, is very low. Resistance to EGFR therapy may stem from aberrant receptor trafficking. Cdc42 is known to affect EGFR downregulation by

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10

Bretou, Marine. "Regulation of the dynamics of the fusion pore : importance of the SNARE protein synaptobrevin 2 and of the Rho GTPase Cdc42." Paris 7, 2010. http://www.theses.fr/2010PA077157.

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L'exocytose nécessite la formation d'un pore de fusion. Le pore initial est étroit ; seules de petites molécules sont libérées. Quand le pore s'élargit les macromolécules sont libérées. J'ai étudié le rôle de deux protéines sur la dilatation du pore: la protéine SNARE synaptobrévine 2 (Syb2), et la Rhô GTPase Cdc42. L'assemblage des SNAREs fournirait l'énergie nécessaire à la fusion. L'insertion d'un espacer dans le domaine juxtamembranaire de Syb2 ne modifie pas la fréquence des événements d'exocytose détectés par ampérométrie à 1|jM [Ca2+], mais empêche l'apparition d'une composante de sécré

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11

Meir, Michael [Verfasser], and Nicolas [Akademischer Betreuer] Schlegel. "Bedeutung der desmosomalen Adhäsion und Rolle der Rho-GTPasen RhoA, Rac1 und Cdc42 für die Regulation der Darmbarriere / Michael Meir. Betreuer: Nicolas Schlegel." Würzburg : Universität Würzburg, 2013. http://d-nb.info/1107802563/34.

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12

Leung, Daisy W. "Biochemical and biophysical characterization of the allosteric equilibrium of the Wiskott-Aldrich Syndrome protein." Access to abstract only; dissertation is embargoed until after 12/20/2006, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=131.

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13

Annan, Robert Bruce. "Roles and regulation of «Saccharomyces cerevisiae» Rho-type GTPases Rho5p and Cdc42p." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32262.

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The eukaryotic Rho family of GTPases acts as central regulators of numerous processes, including the polarization of cell morphology, membrane transport, transcription, and MAPK pathway signaling. As GTPases, Rho proteins act as molecular switches which, in the GTP-bound form, transduce upstream signals to a variety of downstream effectors, thereby generating appropriate cellular responses. As central nodes of signaling, they are subject to strict regulation, and the regulation of the GTP-GDP cycle of Rho

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14

Aldharee, Hitham Abdulrahman. "Role of ERK3 in Regulating RhoGDI1-PAKs Signaling Axis." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1498007023965276.

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15

Böhm, Stefanie. "The Cdc48 Shp1 complex mediates cell cycle progression by positive regulation of Glc7." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-154660.

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16

Rumpf, Sebastian. "Regulation des Abbaus von Cdc48-Substraten durch die antagonistischen Aktivitäten von Ufd2 und Ufd3." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-54278.

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17

Jensen, Bryan. "Regulation of the G1 to S-phase transition in S. cerevisiae by CDC4 /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/10257.

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18

Ewert-Krzemieniewska, Katarzyna. "Investigation into the regulation of DNA repair by the S. pombe cell cycle kinase Cdc2-cyclinB." Thesis, Bangor University, 2009. https://research.bangor.ac.uk/portal/en/theses/investigation-into-the-regulation-of-dna-repair-by-the-spombe-cell-cycle-kinase-cdc2cyclinb(71f3241d-b969-4ff1-9b16-47161f91b755).html.

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The work presented in this thesis proposes two novel functions for S. pombe Cdc2 in the cell cycle-dependent coordination of DNA recombination: (i) during unperturbed cell cycle and (ii) in response to camptothecin (CPT)-induced DNA breaks. In unperturbed cells, in vivo elevated Cdc2 activity causes problems during DNA replication that lead to an increase in spontaneous gene conversion between sister chromatids and enhanced loss of a non-essential minichromosome. Data presented here suggest that Cdc2 regulates the anti-recombinogenic activity of the Srs2 DNA helicase to prevent such spontaneou

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19

Köhler, Tim. "Regulation of growth and development by the small GTPase Cdc42p and the transcription factor Tec1p in Saccharomyces cerevisiae." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969652704.

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20

Böhm, Stefanie [Verfasser], and Stefan [Akademischer Betreuer] Jentsch. "The Cdc48 Shp1 complex mediates cell cycle progression by positive regulation of Glc7 / Stefanie Böhm. Betreuer: Stefan Jentsch." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1032131713/34.

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21

Mavrakis, Konstantinos J. "Functional analysis of DEF6 and def8 revealed DEF6 as a novel activator of Rac, Cdc42 and Rho GTPases regulating cell morphology." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404145.

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22

Gao, Yanzhe. "Regulation of The DNA Unwinding Element Binding Protein DUE-B in The Cell." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1355250568.

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23

Bryant, Victoria. "CMG Helicase Assembly and Activation: Regulation by c-Myc through Chromatin Decondensation and Novel Therapeutic Avenues for Cancer Treatment." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6191.

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The CMG (Cdc45, MCM, GINS) helicase is required for cellular proliferation and functions to unwind double-stranded DNA to allow the replication machinery to duplicate the genome. Cancer cells mismanage helicase activation through a variety of mechanisms, leading to the potential for the development of novel anti-cancer treatments. Mammalian cells load an excess of MCM complexes that act as reserves for new replication origins to be created when replication forks stall due to stress conditions, such as drug treatment. Targeting the helicase through inhibition of the MCM complex has sensitized c

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24

Quaresma, Paula Gabriele Fernandes 1987. "Estudo da regulação da proteína CDC2-Like Kinase (Clk2) em hipotálamo e fígado de camundongos controles e obesos = CDC2-Like Kinase (Clk2) hypothalamic and hepatic regulation in lean and obese mice." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311558.

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Orientador: Patrícia de Oliveira Prada<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T14:12:45Z (GMT). No. of bitstreams: 1 Quaresma_PaulaGabrieleFernandes_M.pdf: 949361 bytes, checksum: 237d0acc0b5bc5358adba045381b4a92 (MD5) Previous issue date: 2012<br>Resumo: O hipotálamo é um órgão crucial na regulação do balanço energético por integrar sinais hormonais e nutricionais de órgão periféricos. O hormônio produzido pelo pâncreas - insulina - e o hormônio derivado de células adiposas - leptina- reconhecidam

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25

Winters, Zoe Ellen. "The role of p53 in the regulation of Cdc2 and cyclin B1 in radiation-induced G2 arrest in human cells." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299469.

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26

Birot, Adrien. "Regulation of fission yeast cohesin by the Cyclin Dependent Kinase PeF1." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0386/document.

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Le complexe cohésine est un complexe protéique en forme d'anneau composé de quatre sous-unités essentielles très conservées: Smc1, Smc3, Rad21 et Scc3. Par sa capacité à encercler les molécules d’ADN, les cohésines participent à de nombreux processus cellulaires tels que la ségrégation des chromosomes, la signalisation et la réparation des dommages à l’ADN, la régulation de la transcription et l'organisation du génome. Pour assurer ces différentes fonctions biologiques les cohésines doivent être finement régulées à la fois dans le temps et l’espace. Ces régulations reposent en partie sur le co

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27

Bhaduri, Samyabrata. "Regulation of CDK1 Activity during the G1/S Transition in S. cerevisiae through Specific Cyclin-Substrate Docking: A Dissertation." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/871.

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Several cell cycle events require specific forms of the cyclin-CDK complexes. It has been known for some time that cyclins not only contribute by activating the CDK but also by choosing substrates and/or specifying the location of the CDK holoenzyme. There are several examples of B-type cyclins identifying certain peptide motifs in their specific substrates through a conserved region in their structure. Such interactions were not known for the G1 class of cyclins, which are instrumental in helping the cell decide whether or not to commit to a new cell cycle, a function that is non-redundant wi

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Kommajosyula, Naveen. "Regulation of DNA Replication Origins in Fission Yeast: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/436.

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Cells need to complete DNA replication in a timely and error-free manner. To ensure that replication is completed efficiently and in a finite amount of time, cells regulate origin firing. To prevent any errors from being transmitted to the next generation, cells have the checkpoint mechanism. The S-phase DNA damage slows replication to allow the cell to repair the damage. The mechanism of replication slowing by the checkpoint was not clear in fission yeast, Schizosaccharomyces pombe, at the start of my thesis. The downstream targets of the DNA damage checkpoint in fission yeast were also uncle

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29

Borgne, Annie. "Etude de la regulation de cdc2/cycline b a la transition prophase/metaphase de l'ovocyte d'etoile de mer. Caracterisation des effets de la roscovitine, un nouvel inhibiteur chimique de cdk." Paris 6, 1998. http://www.theses.fr/1998PA066422.

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La transition prophase/metaphase du cycle cellulaire est regulee par cdc2/cycline b (ou mpf, m-phase promoting factor). En prophase, la kinase se trouve sous la forme d'un complexe inactif, cdc2 etant phosphorylee sur thr-14 et tyr-15 (forme t p-y p) et la cycline b etant non phosphorylee. L'activation de la kinase se deroule en deux etapes concomitantes : 1) dephosphorylation de cdc2 par la phosphatase cdc25, qui active la kinase (forme t-y), 2) phosphorylation de la cycline b, qui permet la translocation du complexe dans le noyau ou se trouvent ses substrats. En utilisant l'ovocyte d'etoile

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30

Vendrell, Arasa Alexandre. "SCF cdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7153.

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L'activació sostinguda de Hog1 porta a una inhibició del creixement cel·lular. En aquest treball, hem observat que el fenotip de letalitat causat per l'activació sostinguda de Hog1 és parcialment inhibida per la mutació del complexe SCFCDC4. La inhibició de la mort causada per l'activació sostinguda de Hog1 depèn de la via d'extensió de la vida. Quan Hog1 s'activa de manera sostinguda, la mutació al complexe SCFCDC4 fa que augmenti l'expressió gènica depenent de Msn2 i Msn4 que condueix a una sobreexpressió del gen PNC1 i a una hiperactivació de la deacetilassa Sir2. La hiperactivació de Sir2

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31

Perl, Abbey Leigh. "Leveraging Small Molecule Activators of Protein Phosphatase 2A (PP2A) toElucidate PP2As Role in Regulating DNA Replication and Apoptosis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1574418174603893.

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32

Grewal, Navneet. "Identification of amino acids involved in Cdc42-calmodulin interaction and regulation of Cdc42 activation." 2015. http://hdl.handle.net/1993/30716.

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Cdc42 is a member of Rho family of Ras GTPase superfamily and has been shown to regulate actin cytoskeleton re-organization and filopodia formation. Calmodulin (CaM) is a calcium modulating protein and regulates calcium dependent signal transduction pathways in the cell. According to CaM target database analysis, amino acid region 151-163 of Cdc42 has a potential CaM binding domain that interacts with CaM. In the present work, we have investigated putative CaM binding region in Cdc42. In addition the role of basic amino acids K153 and K163 within this region in Cdc42 interaction with CaM and e

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33

Elsaraj, Sherif. "Regulation of Rac1 and Cdc42 GTPases through direct interaction with calmodulin." 2006. http://hdl.handle.net/1993/20344.

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34

Meir, Michael. "Bedeutung der desmosomalen Adhäsion und Rolle der Rho-GTPasen RhoA, Rac1 und Cdc42 für die Regulation der Darmbarriere." Doctoral thesis, 2013. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-85111.

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Eine intakte Darmbarriere ist überlebensnotwendig. Bei einigen Erkrankungen kann eine Störung der Darmbarriere zur Translokation von Bakterien aus dem Lumen des Darmes in den menschlichen Körper führen, die septische Entzündungsprozesse auslösen können. In dieser Arbeit untersuchten wir zum einen die Bedeutung der desmosomalen Adhäsion für die Darmbarriere und zum anderen die Rolle der Rho-GTPasen in der Regulation der Darmbarriere. Für unsere Untersuchungen charakterisierten wir Caco2 Zellen, von denen wir nachweisen konnten, dass sie ein geeignetes Modell für die Darmbarriere sind. Wir konnt

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35

Diederich, Wendy-Anneliese [Verfasser]. "Apolipoprotein AI und HDL3 inhibieren die Migration humaner Monozyten durch Induktion der Cholesterinefflux und Regulation von CDC42 / vorgelegt von Wendy-Anneliese Diederich." 2006. http://d-nb.info/980289513/34.

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Köhler, Tim. "Regulation of Growth and Development by the Small GTPase Cdc42p and the Transcription Factor Tec1p in Saccharomyces cerevisiae." Doctoral thesis, 2003. http://hdl.handle.net/11858/00-1735-0000-0006-AE6F-C.

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37

Deplazes, Joëlle [Verfasser]. "Die Rolle der kleinen Rho-GTPasen Rac1, Rho und Cdc42 in der Regulation der Motilität und Invasion von Tumorzellen mit einer Mutation in E-Cadherin / Joëlle Deplazes." 2009. http://d-nb.info/995844062/34.

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Kalwat, Michael Andrew. "F-Actin regulation of SNARE-mediated insulin secretion." Thesis, 2013. http://hdl.handle.net/1805/3624.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>In response to glucose, pancreatic islet beta cells secrete insulin in a biphasic manner, and both phases are diminished in type 2 diabetes. In beta cells, cortical F-actin beneath the plasma membrane (PM) prevents insulin granule access to the PM and glucose stimulates remodeling of this cortical F-actin to allow trafficking of insulin granules to the PM. Glucose stimulation activates the small GTPase Cdc42, which then activates p21-activated kinase 1 (PAK1); both Cdc42 and PAK1 are required for insulin secretion. In conjunction w

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Weidmann, Rolf Günter [Verfasser]. "Endothel und Regulation der Inflammation : Überexpression inaktiver Mutanten der kleinen GTP-bindenden Proteine RhoA/Rac1/Cdc42 inhibiert die LPS-induzierte Expression von Interleukin-8/CXCL8 in humanen mikrovaskulären Endothelzellen / von Rolf Günter Weidmann." 2005. http://d-nb.info/978803736/34.

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Pollok, Sibyll [Verfasser]. "Untersuchungen zur Regulation des humanen Replikationsfaktors Cdc45 / von Sibyll Pollok." 2007. http://d-nb.info/985809736/34.

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Rumpf, Sebastian [Verfasser]. "Regulation des Abbaus von Cdc48-Substraten durch die antagonistischen Aktivitäten von Ufd2 und Ufd3 / vorgelegt von Sebastian Rumpf." 2006. http://d-nb.info/980478286/34.

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Kolawa, Natalie J. "Proteomic Analysis of the Cdc48/Ubx Network Identifies a Role for Ubx2 in the Regulation of Lipid Biosynthesis." Thesis, 2013. https://thesis.library.caltech.edu/7761/1/kolawa_natalie_2013_thesis.pdf.

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<p>Cdc48/p97 is an essential, highly abundant hexameric member of the AAA (ATPase associated with various cellular activities) family. It has been linked to a variety of processes throughout the cell but it is best known for its role in the ubiquitin proteasome pathway. In this system it is believed that Cdc48 behaves as a segregase, transducing the chemical energy of ATP hydrolysis into mechanical force to separate ubiquitin-conjugated proteins from their tightly-bound partners.</p> <p>Current models posit that Cdc48 is linked to its substrates through a variety of adaptor proteins, incl

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43

Thattikota, Yogitha. "Regulation of chromosome condensation in Saccharomyces cerevisiae during mitosis." Thèse, 2017. http://hdl.handle.net/1866/19316.

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Köhler, Tim [Verfasser]. "Regulation of growth and development by the small GTPase Cdc42p and the transcription factor Tec1p in Saccharomyces cerevisiae / vorgelegt von Tim Köhler." 2003. http://d-nb.info/969652704/34.

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45

Van, Zijl Magdalena Catherina. "In vitro effects of 2-methoxyestradiol, an endogenous estrogen, on MCF-12A and MCF-7 cell cycle progression." Diss., 2006. http://hdl.handle.net/2263/26594.

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2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite with antiproliferative and antiangiogenic properties. 2ME also plays an active role in the induction of apoptosis, especially in cancerous cells. These properties have been confirmed by various in vitro and in vivo studies and render 2ME a potential antitumor agent. The mechanism of action of 2ME, however, is not yet fully elucidated and it is believed that multiple mechanisms are involved that may be dependent on cell type. The aim of this study was to investigate the differential effects of 2ME on cell growth, morphology and spind

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