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Journal articles on the topic 'Regulation scaffolding'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Alderton, Gemma K. "Scaffolding the regulation of hypoxia." Nature Reviews Cancer 12, no. 3 (2012): 153. http://dx.doi.org/10.1038/nrc3242.

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2

Pakpahan, Nicolaus, Kamid Kamid, and Damris Muhammad. "Enhancing mathematical concept understanding: The influence of scaffolding in team-assisted individualization based on self-regulation." Indonesian Journal of Science and Mathematics Education 8, no. 1 (2025): 41. https://doi.org/10.24042/ijsme.v8i1.23481.

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Effective learning requires strategies that support students' understanding of mathematical concepts and promote independent learning. This study examines the impact of scaffolding in Team Assisted Individualization (TAI) on students' mathematical conceptual understanding and the role of self-regulation in the learning process. The research employs a quasi-experimental design with a nonequivalent pre-test and post-test control group design involving 109 randomly selected high school students. Data analysis was conducted to compare the effectiveness of TAI with scaffolding, TAI without scaffold

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Myruski, Sarah, Samantha Birk, Mayumi Karasawa, et al. "Neural signatures of child cognitive emotion regulation are bolstered by parental social regulation in two cultures." Social Cognitive and Affective Neuroscience 14, no. 9 (2019): 947–56. http://dx.doi.org/10.1093/scan/nsz070.

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Abstract Caregiver impact on the efficacy of cognitive emotion regulation (ER; i.e. reappraisal) during childhood is poorly understood, particularly across cultures. We tested the hypothesis that in children from Japan and the USA, a neurocognitive signature of effective reappraisal, the late positive potential (LPP), will be bolstered by cognitive scaffolding by parents, and explored whether the two cultures differed in whether mere physical proximity of parents provides similar benefit. Five-to-seven-year-olds (N = 116; nJapan = 58; nUSA = 58) completed a directed reappraisal task (EEG-recor

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Umar, Tariq, Nnedinma Umeokafor, Mohamed Shaik Honnur Vali, and Asad Zia. "A Comparative Study of Occupational Safety and Health (OS&H) Regulations in United States, United Kingdom, Australia, South Africa, and Oman." IOP Conference Series: Earth and Environmental Science 1101, no. 3 (2022): 032016. http://dx.doi.org/10.1088/1755-1315/1101/3/032016.

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Abstract This article identifies the gaps in OS&H regulations in Omani construction using a critical review and analysis of relevant literature. Four countries United States of America (USA), United Kingdom (UK), Australia (AUS), and South Africa (SA) were then compared to Oman in relation to selected regulations. The study reveals fall from a height is one of the main causes of accidents in different sectors in Oman however there are no specific regulations that cover this cause of accidents in detail. The only regulation which applies to the “fall from a height” is the regulation of OS&a

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Mauban, J. R. H., M. O’Donnell, S. Warrier, S. Manni, and M. Bond. "AKAP-Scaffolding Proteins and Regulation of Cardiac Physiology." Physiology 24, no. 2 (2009): 78–87. http://dx.doi.org/10.1152/physiol.00041.2008.

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A kinase anchoring proteins (AKAPs) compose a growing list of diverse but functionally related proteins defined by their ability to bind to the regulatory subunit of protein kinase A. AKAPs perform an integral role in the spatiotemporal modulation of a multitude of cellular signaling pathways. This review highlights the extensive role of AKAPs in cardiac excitation/contraction coupling and cardiac physiology. The literature shows that particular AKAPs are involved in cardiac Ca2+ influx, release, reuptake, and myocyte repolarization. Studies have also suggested roles for AKAPs in cardiac remod

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He, Dao-Yao, Jérémie Neasta, and Dorit Ron. "Epigenetic Regulation ofBDNFExpression via the Scaffolding Protein RACK1." Journal of Biological Chemistry 285, no. 25 (2010): 19043–50. http://dx.doi.org/10.1074/jbc.m110.100693.

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7

Ferreira, Marília Mendes. "Constraints to peer scaffolding." Trabalhos em Linguística Aplicada 47, no. 1 (2008): 9–29. http://dx.doi.org/10.1590/s0103-18132008000100002.

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Several studies, usually carried out in settings that are conducive to interaction, demonstrate peers can provide mutual scaffolding effectively. In contrast, this article focuses on constraints to peer scaffolding which, possibly, happened because of participants' demotivating learning environment. Analysis is based on the video and audio recordings of the performance of two beginning Brazilian students carrying out two oral tasks in an EFL class. Task one consists of an information gap and task two, of a communicative drill. The following constraints were identified: 1) the less capable peer

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8

Augustin, Vanessa, and Stefan Kins. "Fe65: A Scaffolding Protein of Actin Regulators." Cells 10, no. 7 (2021): 1599. http://dx.doi.org/10.3390/cells10071599.

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The scaffolding protein family Fe65, composed of Fe65, Fe65L1, and Fe65L2, was identified as an interaction partner of the amyloid precursor protein (APP), which plays a key function in Alzheimer’s disease. All three Fe65 family members possess three highly conserved interaction domains, forming complexes with diverse binding partners that can be assigned to different cellular functions, such as transactivation of genes in the nucleus, modulation of calcium homeostasis and lipid metabolism, and regulation of the actin cytoskeleton. In this article, we rule out putative new intracellular signal

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9

Tyagarajan, Shiva K., Himanish Ghosh, Gonzalo E. Yévenes та ін. "Regulation of GABAergic synapse formation and plasticity by GSK3β-dependent phosphorylation of gephyrin". Proceedings of the National Academy of Sciences 108, № 1 (2010): 379–84. http://dx.doi.org/10.1073/pnas.1011824108.

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Postsynaptic scaffolding proteins ensure efficient neurotransmission by anchoring receptors and signaling molecules in synapse-specific subcellular domains. In turn, posttranslational modifications of scaffolding proteins contribute to synaptic plasticity by remodeling the postsynaptic apparatus. Though these mechanisms are operant in glutamatergic synapses, little is known about regulation of GABAergic synapses, which mediate inhibitory transmission in the CNS. Here, we focused on gephyrin, the main scaffolding protein of GABAergic synapses. We identify a unique phosphorylation site in gephyr

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10

Okada, Yasunobu. "A scaffolding for regulation of volume-sensitive Cl−channels." Journal of Physiology 520, no. 1 (1999): 2. http://dx.doi.org/10.1111/j.1469-7793.1999.00002.x.

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11

Kim, Kiae, Yeonjin Han, Longhan Duan та Ka Young Chung. "Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins". International Journal of Molecular Sciences 23, № 2 (2022): 1000. http://dx.doi.org/10.3390/ijms23021000.

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β-arrestins were initially identified to desensitize and internalize G-protein-coupled receptors (GPCRs). Receptor-bound β-arrestins also initiate a second wave of signaling by scaffolding mitogen-activated protein kinase (MAPK) signaling components, MAPK kinase kinase, MAPK kinase, and MAPK. In particular, β-arrestins facilitate ERK1/2 or JNK3 activation by scaffolding signal cascade components such as ERK1/2-MEK1-cRaf or JNK3-MKK4/7-ASK1. Understanding the precise molecular and structural mechanisms of β-arrestin-mediated MAPK scaffolding assembly would deepen our understanding of GPCR-media

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12

Tyan, Leonid, Daniel Turner, Karlie R. Komp, Roman Y. Medvedev, Evi Lim, and Alexey V. Glukhov. "Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes." American Journal of Physiology-Heart and Circulatory Physiology 320, no. 2 (2021): H787—H797. http://dx.doi.org/10.1152/ajpheart.00569.2020.

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Angiotensin II receptor 1 is associated with caveolae and caveolar scaffolding protein caveolin-3 in mouse atrial myocytes that is required for the regulation of Ito by angiotensin II. Downregulation of caveolae/caveolin-3 disrupts this regulation and may be implicated in pathophysiological atrial remodeling.

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13

Calabrese, Barbara, Margaret S. Wilson, and Shelley Halpain. "Development and Regulation of Dendritic Spine Synapses." Physiology 21, no. 1 (2006): 38–47. http://dx.doi.org/10.1152/physiol.00042.2005.

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Dendritic spines are small protrusions from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. They play critical roles in synaptic transmission and plasticity. Recent advances in imaging and molecular technologies reveal that spines are complex, dynamic structures that contain a dense array of cytoskeletal, transmembrane, and scaffolding molecules. Several neurological and psychiatric disorders exhibit dendritic spine abnormalities.

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Redden, John M., Andrew V. Le, Arpita Singh, Kyle Federkiewicz, Samantha Smith, and Kimberly L. Dodge-Kafka. "Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms." Biochemical Journal 446, no. 2 (2012): 301–9. http://dx.doi.org/10.1042/bj20120366.

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The regulation of kinases by scaffolding proteins greatly contributes to the fidelity of signal transduction. In the present study, we explored an interaction between the ubiquitous enzyme PKC (protein kinase C) and the scaffolding protein AKAP7 (A-kinase-anchoring protein 7). Using protein biochemistry and surface plasmon resonance approaches, we demonstrate that both AKAP7γ and AKAP7α are capable of high-affinity interactions with multiple isoenzymes of PKC. Furthermore, this interaction is achieved via multi-site binding on both proteins. FRET (fluorescence resonance energy transfer) analys

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15

Herrero, Ana, David Matallanas, and Walter Kolch. "The spatiotemporal regulation of RAS signalling." Biochemical Society Transactions 44, no. 5 (2016): 1517–22. http://dx.doi.org/10.1042/bst20160127.

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Nearly 30% of human tumours harbour mutations in RAS family members. Post-translational modifications and the localisation of RAS within subcellular compartments affect RAS interactions with regulator, effector and scaffolding proteins. New insights into the control of spatiotemporal RAS signalling reveal that activation kinetics and subcellular compartmentalisation are tightly coupled to the generation of specific biological outcomes. Computational modelling can help utilising these insights for the identification of new targets and design of new therapeutic approaches.

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16

Liebmann, Thomas, Nicolas Fritz, Markus Kruusmägi, et al. "Regulation of Neuronal Na,K-ATPase by Extracellular Scaffolding Proteins." International Journal of Molecular Sciences 19, no. 8 (2018): 2214. http://dx.doi.org/10.3390/ijms19082214.

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Neuronal activity leads to an influx of Na+ that needs to be rapidly cleared. The sodium-potassium ATPase (Na,K-ATPase) exports three Na+ ions and imports two K+ ions at the expense of one ATP molecule. Na,K-ATPase turnover accounts for the majority of energy used by the brain. To prevent an energy crisis, the energy expense for Na+ clearance must provide an optimal effect. Here we report that in rat primary hippocampal neurons, the clearance of Na+ ions is more efficient if Na,K-ATPase is laterally mobile in the membrane than if it is clustered. Using fluorescence recovery after photobleachin

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17

Kinnunen, Patrick C., Gary D. Luker, Kathryn E. Luker, and Jennifer J. Linderman. "Computational modeling implicates protein scaffolding in p38 regulation of Akt." Journal of Theoretical Biology 555 (December 2022): 111294. http://dx.doi.org/10.1016/j.jtbi.2022.111294.

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18

Fu, Meng-meng, and Erika L. F. Holzbaur. "Integrated regulation of motor-driven organelle transport by scaffolding proteins." Trends in Cell Biology 24, no. 10 (2014): 564–74. http://dx.doi.org/10.1016/j.tcb.2014.05.002.

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19

Robinson, Julia B., Barbara M. Burns, and Deborah Winders Davis. "Maternal scaffolding and attention regulation in children living in poverty." Journal of Applied Developmental Psychology 30, no. 2 (2009): 82–91. http://dx.doi.org/10.1016/j.appdev.2008.10.013.

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20

Lyons, Traci R., Jackie Thorburn, Philip W. Ryan, Andrew Thorburn, Steven M. Anderson, and C. Kenneth Kassenbrock. "Regulation of the Pro-apoptotic Scaffolding Protein POSH by Akt." Journal of Biological Chemistry 282, no. 30 (2007): 21987–97. http://dx.doi.org/10.1074/jbc.m704321200.

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21

Eckert, Richard L., Mari T. Kaartinen, Maria Nurminskaya, et al. "Transglutaminase Regulation of Cell Function." Physiological Reviews 94, no. 2 (2014): 383–417. http://dx.doi.org/10.1152/physrev.00019.2013.

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Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease. This review highlights the mechanism of action of these proteins with respect to their structure, impact on cell differentiation and survival, role in cancer development and progression, and function in signal transduction. We also discuss the mechanisms whereby TG level is controlled and how TGs control downstream targets. The studies described herein begin to

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22

Leith, Georgia, Nicola Yuill, and Alison Pike. "Scaffolding under the microscope: Applying self-regulation and other-regulation perspectives to a scaffolded task." British Journal of Educational Psychology 88, no. 2 (2017): 174–91. http://dx.doi.org/10.1111/bjep.12178.

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23

Kotelevets, Larissa, and Eric Chastre. "A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer." Cancers 13, no. 17 (2021): 4264. http://dx.doi.org/10.3390/cancers13174264.

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Scaffolding molecules exert a critical role in orchestrating cellular response through the spatiotemporal assembly of effector proteins as signalosomes. By increasing the efficiency and selectivity of intracellular signaling, these molecules can exert (anti/pro)oncogenic activities. As an archetype of scaffolding proteins with tumor suppressor property, the present review focuses on MAGI1, 2, and 3 (membrane-associated guanylate kinase inverted), a subgroup of the MAGUK protein family, that mediate networks involving receptors, junctional complexes, signaling molecules, and the cytoskeleton. M

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24

Riddle, Melissa A., Jennifer M. Hughes, and Benjimen R. Walker. "Role of caveolin-1 in endothelial BKCa channel regulation of vasoreactivity." American Journal of Physiology-Cell Physiology 301, no. 6 (2011): C1404—C1414. http://dx.doi.org/10.1152/ajpcell.00013.2011.

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A novel vasodilatory influence of endothelial cell (EC) large-conductance Ca2+-activated K+ (BKCa) channels is present following in vivo exposure to chronic hypoxia (CH) and may exist in other pathological states. However, the mechanism of channel activation that results in altered vasoreactivity is unknown. We tested the hypothesis that CH removes an inhibitory effect of the scaffolding domain of caveolin-1 (Cav-1) on EC BKCa channels to permit activation, thereby affecting vasoreactivity. Experiments were performed on gracilis resistance arteries and ECs from control and CH-exposed (380 mmHg

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25

Stephenson, F. A. "Structure and trafficking of NMDA and GABAA receptors." Biochemical Society Transactions 34, no. 5 (2006): 877–81. http://dx.doi.org/10.1042/bst0340877.

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The fidelity of synaptic function is dependent on the expression of the appropriate neurotransmitter receptor subtype, the targeting and trafficking of receptors to synapses as well as the regulation of the actual number of receptors at synapses. GABAA (γ-aminobutyric acid type A) receptors and NMDA (N-methyl-D-aspartate) receptors are both examples of ligand-gated, heteromeric neurotransmitter receptors whose cell-surface expression is dynamic and tightly regulated. NMDA receptors are localized at excitatory synapses. These synapses are highly structured but dynamic, with the interplay betwee

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26

Sauvanet, Cécile, Damien Garbett, and Anthony Bretscher. "The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell-cycle phosphorylation." Molecular Biology of the Cell 26, no. 20 (2015): 3615–27. http://dx.doi.org/10.1091/mbc.e15-07-0498.

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We examine the dynamics and function of the apical scaffolding protein E3KARP/NHERF2, which consists of two PDZ domains and a tail containing an ezrin-binding domain. The exchange rate of E3KARP is greatly enhanced during mitosis due to phosphorylation at Ser-303 in its tail region. Whereas E3KARP can substitute for the function of the closely related scaffolding protein EBP50/NHERF1 in the formation of interphase microvilli, E3KARP S303D cannot. Moreover, the S303D mutation enhances the in vivo dynamics of the E3KARP tail alone, whereas in vitro the interaction of E3KARP with active ezrin is

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27

Lavigne, John V., Karen R. Gouze, Joyce Hopkins, and Fred B. Bryant. "A multidomain cascade model of early childhood risk factors associated with oppositional defiant disorder symptoms in a community sample of 6-year-olds." Development and Psychopathology 28, no. 4pt2 (2015): 1547–62. http://dx.doi.org/10.1017/s0954579415001194.

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AbstractThe present study examined a cascade model of age 4 and 5 contextual, parent, parenting, and child factors on symptoms of oppositional defiant disorder (ODD) at age 6 in a diverse community sample of 796 children. Contextual factors include socioeconomic status, family stress, and conflict; parent factors included parental depression; parenting factors included parental hostility, support, and scaffolding skills; child factors included child effortful control (EC), negative affect (NA), and sensory regulation. Direct effects of age 5 conflict, hostility, scaffolding, EC, and NA were fo

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Riddle, Melissa A., and Benjimen R. Walker. "Regulation of endothelial BK channels by heme oxygenase-derived carbon monoxide and caveolin-1." American Journal of Physiology-Cell Physiology 303, no. 1 (2012): C92—C101. http://dx.doi.org/10.1152/ajpcell.00356.2011.

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A novel vasodilatory influence of endothelial cell (EC) large-conductance Ca2+-activated K+ (BK) channels is present after in vivo exposure to chronic hypoxia (CH) and may exist in other pathological states. However, the mechanism of channel activation that results in altered vasoreactivity is unknown. Previously, we demonstrated that inhibition of either BK channels or heme oxygenase (HO) restores vasoconstrictor reactivity after CH. Additionally, administration of the scaffolding domain of caveolin (Cav)-1 inhibits EC BK activity and restores vasoconstrictor reactivity in this setting. These

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Bird, Kalynn M., and Paul M. Jenkins. "Regulation of neuronal ankyrin localization and function by post-translational modifications." Biochemical Society Transactions 53, no. 02 (2025): 497–507. https://doi.org/10.1042/bst20253016.

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Ankyrins are a family of intracellular scaffolding proteins that control the subcellular localization of a host of critically important signaling proteins within neurons, including many proteins associated with neurological disease. Ankyrin proteins are a vital component of the neuron. These scaffolding proteins must be spatially and temporally arranged to interact with their binding partners and facilitate proper neuronal signaling. Dysfunction of ankyrins is associated with neurodevelopmental disorders such as epilepsy and autism spectrum disorder. Despite the high degree of sequence similar

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Nussinov, Ruth, Buyong Ma, and Chung-Jung Tsai. "A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834, no. 5 (2013): 820–29. http://dx.doi.org/10.1016/j.bbapap.2012.12.014.

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31

Lin, Amy W., and Heng-Ye Man. "Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins." Neural Plasticity 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/432057.

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The human brain is made up of an extensive network of neurons that communicate by forming specialized connections called synapses. The amount, location, and dynamic turnover of synaptic proteins, including neurotransmitter receptors and synaptic scaffolding molecules, are under complex regulation and play a crucial role in synaptic connectivity and plasticity, as well as in higher brain functions. An increasing number of studies have established ubiquitination and proteasome-mediated degradation as universal mechanisms in the control of synaptic protein homeostasis. In this paper, we focus on

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Tazkia, Savirra, and Tatag Yuli Eko Siswono. "Scaffolding in Supporting Senior High School Students’ Critical Thinking Skills in Sequences and Series Problems." MATHEdunesa 12, no. 1 (2023): 207–20. http://dx.doi.org/10.26740/mathedunesa.v12n1.p207-220.

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Critical thinking skills are important for every individual, that they need to be developed in classroom learning, one of which is through learning sequences and series material. However, there are still many students who have difficulty solving problems on sequences and series material, so they need help using scaffolding. This study aims to describe students' thinking skills on sequences and series material, as well as scaffolding which helps students' critical thinking skills in solving sequence and series material questions. The subjects of this study were 2 students who failed to complete

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Lovero, Kathryn L., Yuko Fukata, Adam J. Granger, Masaki Fukata, and Roger A. Nicoll. "The LGI1–ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function." Proceedings of the National Academy of Sciences 112, no. 30 (2015): E4129—E4137. http://dx.doi.org/10.1073/pnas.1511910112.

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Synapse development is coordinated by a number of transmembrane and secreted proteins that come together to form synaptic organizing complexes. Whereas a variety of synaptogenic proteins have been characterized, much less is understood about the molecular networks that support the maintenance and functional maturation of nascent synapses. Here, we demonstrate that leucine-rich, glioma-inactivated protein 1 (LGI1), a secreted protein previously shown to modulate synaptic AMPA receptors, is a paracrine signal released from pre- and postsynaptic neurons that acts specifically through a disintegri

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34

Sun, Jin, and Yixuan Tang. "Maternal scaffolding strategies and early development of self-regulation in Chinese preschoolers." Early Child Development and Care 189, no. 9 (2017): 1525–37. http://dx.doi.org/10.1080/03004430.2017.1395874.

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Meyer, Debra K., and Julianne C. Turner. "Using Instructional Discourse Analysis to Study the Scaffolding of Student Self-Regulation." Educational Psychologist 37, no. 1 (2002): 17–25. http://dx.doi.org/10.1207/s15326985ep3701_3.

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36

Tamanini, Anna, Enrica Fabbri, Tiziana Jakova, et al. "A Peptide-Nucleic Acid Targeting miR-335-5p Enhances Expression of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene with the Possible Involvement of the CFTR Scaffolding Protein NHERF1." Biomedicines 9, no. 2 (2021): 117. http://dx.doi.org/10.3390/biomedicines9020117.

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(1) Background: Up-regulation of the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) might be of great relevance for the development of therapeutic protocols for cystic fibrosis (CF). MicroRNAs are deeply involved in the regulation of CFTR and scaffolding proteins (such as NHERF1, NHERF2 and Ezrin). (2) Methods: Content of miRNAs and mRNAs was analyzed by RT-qPCR, while the CFTR and NHERF1 production was analyzed by Western blotting. (3) Results: The results here described show that the CFTR scaffolding protein NHERF1 can be up-regulated in bronchial epithelial Calu-3 cells by

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Sathish, Venkatachalem, Binxia Yang, Lucas W. Meuchel, et al. "Caveolin-1 and force regulation in porcine airway smooth muscle." American Journal of Physiology-Lung Cellular and Molecular Physiology 300, no. 6 (2011): L920—L929. http://dx.doi.org/10.1152/ajplung.00322.2010.

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Caveolae are specialized membrane microdomains expressing the scaffolding protein caveolin-1. We recently demonstrated the presence of caveolae in human airway smooth muscle (ASM) and the contribution of caveolin-1 to intracellular calcium ([Ca2+]i) regulation. In the present study, we tested the hypothesis that caveolin-1 regulates ASM contractility. We examined the role of caveolins in force regulation of porcine ASM under control conditions as well as TNF-α-induced airway inflammation. In porcine ASM strips, exposure to 10 mM methyl-β-cyclodextrin (CD) or 5 μM of the caveolin-1 specific sca

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38

Heckhausen, Jutta, and Carsten Wrosch. "Challenges to developmental regulation across the life course." International Journal of Behavioral Development 40, no. 2 (2015): 145–50. http://dx.doi.org/10.1177/0165025415588796.

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We discuss the major processes involved in individuals’ motivation and self-regulation of goal striving throughout the life course. While much is regulated based on the biological and societal scaffolding of lifespan development, certain challenges for motivation and self-regulation are more substantial and need to be managed by the individual, providing opportunities for researchers for testing the limits of individual capacities in developmental regulation. These challenging circumstances include major changes in age-graded opportunities for goal pursuit, uncertain or obfuscated opportunitie

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Diviani, Dario, Kimberly L. Dodge-Kafka, Jinliang Li, and Michael S. Kapiloff. "A-kinase anchoring proteins: scaffolding proteins in the heart." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 5 (2011): H1742—H1753. http://dx.doi.org/10.1152/ajpheart.00569.2011.

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The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis. The formation of localized, multiprotein complexes that contain different combinations of cAMP effectors and regulatory enzymes provides the architectural infrastructure for the specialization of the cAMP signaling network. Scaffolds that bind protein kinase A are called “A-kinase anchoring

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40

PENG XIAOHUA, WIRAWATI NGUI, and ASMAA ALSAQQAF. "INTEGRATING MULTIMODAL SCAFFOLDING IN BUSINESS ENGLISH READING USING THE SUPERSTAR PLATFORM: A SYSTEMATIC LITERATURE REVIEW." MANU Jurnal Pusat Penataran Ilmu dan Bahasa (PPIB) 35, no. 2 (2024): 23–46. https://doi.org/10.51200/manu.v35i2.5733.

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Abstract Business English (BE) classes in college require reading proficiency. Multimodal scaffolding (MS), which uses many media to adapt instruction, is growing in popularity. This review evaluates MS on the Superstar Platform for college-level BE reading. The paper begins with a theoretical framework that explains scaffolding in language acquisition and the importance of MS in instructional design. Scaffolding in language acquisition, MS's impact on reading comprehension, and digital learning environments in language training are examined in the article. The research procedure and study sel

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Davis, Michael J., Xin Wu, Timothy R. Nurkiewicz, et al. "Regulation of ion channels by protein tyrosine phosphorylation." American Journal of Physiology-Heart and Circulatory Physiology 281, no. 5 (2001): H1835—H1862. http://dx.doi.org/10.1152/ajpheart.2001.281.5.h1835.

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Ion channels are regulated by protein phosphorylation and dephosphorylation of serine, threonine, and tyrosine residues. Evidence for the latter process, tyrosine phosphorylation, has increased substantially since this topic was last reviewed. In this review, we present a comprehensive summary and synthesis of the literature regarding the mechanism and function of ion channel regulation by protein tyrosine kinases and phosphatases. Coverage includes the majority of voltage-gated, ligand-gated, and second messenger-gated channels as well as several types of channels that have not yet been clone

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42

Seo, Yongbo, Seojung Mo, Suhyun Kim, Hyun Kim, and Hae-Chul Park. "Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS." International Journal of Molecular Sciences 23, no. 21 (2022): 13395. http://dx.doi.org/10.3390/ijms232113395.

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Tamalin is a post-synaptic scaffolding protein that interacts with group 1 metabotropic glutamate receptors (mGluRs) and several other proteins involved in protein trafficking and cytoskeletal events, including neuronal growth and actin reorganization. It plays an important role in synaptic plasticity in vitro by controlling the ligand-dependent trafficking of group 1 mGluRs. Abnormal regulation of mGluRs in the central nervous system (CNS) is associated with glutamate-mediated neurodegenerative disorders. However, the pathological consequences of tamalin deficiency in the CNS are unclear. In

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Castello, Angelo, Michael Engelke, Johannes Tucholski, et al. "Nck proteins are recruited directly to the BCR and regulate PI3K signaling thereby shaping B cell immune responses (P1154)." Journal of Immunology 190, no. 1_Supplement (2013): 190.2. http://dx.doi.org/10.4049/jimmunol.190.supp.190.2.

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Abstract Binding of antigen to the B cell antigen receptor (BCR) triggers the activation of different kinases and the initiation of many signaling pathways required for mounting B-dependent immune responses. Scaffolding proteins, recruited downstream of the BCR, act as signal integrators through the recruitment of multiple signaling effectors. Nck is a family of scaffolding proteins best known for linking phosphotyrosine signals to cytoskeleton regulation but until now uncharacterized in the context of B lymphocytes. In our study, Nck was found to be directly recruited to the Igα tail of the B

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ter Beek, Marlies, Marie-Christine Opdenakker, Alinda W. Spijkerboer, Leonie Brummer, Hidde W. Ozinga, and Jan-Willem Strijbos. "Scaffolding expository history text reading: Effects on adolescents' comprehension, self-regulation, and motivation." Learning and Individual Differences 74 (August 2019): 101749. http://dx.doi.org/10.1016/j.lindif.2019.06.003.

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Grabell, Adam S., Theodore J. Huppert, Frank A. Fishburn, et al. "Neural correlates of early deliberate emotion regulation: Young children’s responses to interpersonal scaffolding." Developmental Cognitive Neuroscience 40 (December 2019): 100708. http://dx.doi.org/10.1016/j.dcn.2019.100708.

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Sabourin, J., C. Cognard, and Bruno Constantin. "Regulation by scaffolding proteins of canonical transient receptor potential channels in striated muscle." Journal of Muscle Research and Cell Motility 30, no. 7-8 (2009): 289–97. http://dx.doi.org/10.1007/s10974-010-9206-9.

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Mohammadi, Sima, and Hamed Zandi. "Scaffolding Self-Regulation in an Online English Language Course: Utility of Contract Learning." Teaching English as a Second or Foreign Language--TESL-EJ 26, no. 4 (2023): 1–33. http://dx.doi.org/10.55593/ej.26104a11.

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As students’ achievement is correlated with self-regulation, finding interventions promoting self-regulated learning (SRL) in online courses is a current focus of research. However, few studies have explored the potential of contract learning in scaffolding and developing SRL in non-traditional learners who have work and family and are at risk of dropout. Here, we investigate the utility of contract learning using a qualitative approach. Using a qualitative approach, we collected data from the experience of one teacher and seven non-traditional learners in an online English for Specific Purpos

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Taylor, Sue. "The Modification of Boerkaert’s (1999) Model of Self-Regulation to Include Younger Learners." Frontiers of Contemporary Education 2, no. 1 (2021): p22. http://dx.doi.org/10.22158/fce.v2n1p22.

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This study of self-regulation draws on Boerkaert’s (1999) model but proposes adaptations. In particular, it examines the role of the teacher in the promotion of self-regulation, and the importance of curriculum for creating opportunities for autonomous learning. Since Boerkaert’s model was devised for older learners, adaptations are proposed to reflect its possible meaning for younger learners, particularly through the supportive scaffolding of their learning and development toward self-regulation. The study uses an international sample survey of children’s responses to curricular experiences,

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Vlasicheva, Victoria Valerevna. "Metacognitive scaffolding in teaching English for law students." Development of education 8, no. 2 (2025): 12–19. https://doi.org/10.31483/r-138843.

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Metacognitive support in foreign language classes for law students is considered as a potentially effective pedagogical technology that fosters students’ ability to self-manage their learning process. The aim of this study was to assess the impact of introducing metacognitive elements into English lessons for law students through a comparative analysis of students’ level of metacognitive awareness before and after the experimental period. The article presents the results of an empirical study involving 30 students, equally divided into two groups (control and experimental). Students’ metacogni

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Akakura, Shin, and Irwin H. Gelman. "Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics: Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling." Journal of Signal Transduction 2012 (June 28, 2012): 1–7. http://dx.doi.org/10.1155/2012/529179.

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Cellular dynamics are controlled by key signaling molecules such as cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). AKAP12/SSeCKS/Gravin (AKAP12) is a scaffold protein for PKA and PKC which controls actin-cytoskeleton reorganization in a spatiotemporal manner. AKAP12 also acts as a tumor suppressor which regulates cell-cycle progression and inhibits Src-mediated oncogenic signaling and cytoskeletal pathways. Reexpression of AKAP12 causes cell flattening, reorganization of the actin cytoskeleton, and the production of normalized focal adhesion structures. Downregulation of AKAP1

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